Jiri Minarik¹, Zuzana Hermanova^2*, Pavla Petrova^3*, Jana Zapletalova^4*, Jan Hrbek^5*, Petra Pusciznova^6*, Jaroslav Bacovsky^6*, Tomas Pika^6*, Miroslav Herman^5* and Vlastimil Scudla^6*

¹University Hospital Olomouc, Olomouc, Czech Republic
²Department of Immunology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Olomouc, Czech Republic
³Department of Clinical Biochemistry, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Olomouc, Czech Republic
⁴Department of Medical Biophysics, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Olomouc, Czech Republic
⁵Department of Radiology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Olomouc, Czech Republic
⁶Department of Hemato-Oncology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Olomouc, Czech Republic

Salomon Manier, MD¹, John Powers, PhD^2*, Antonio Sacco, BS^1*, Siobhan Glavey, MD^3*, Daisy Huynh, BS, MS^1*, Michaela R. Reagan, PhD³, Karma Salem, MD^1*, Michele Moschetta, MD^3*, Yuji Mishima, PhD^1*, Xavier Leleu, MD, PhD⁴, Aldo M Roccaro, MD, PhD¹, George Q. Daley, MD, PhD⁵ and Irene M. Ghobrial, MD⁶

¹Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
²Children's Hospital Boston, Harvard Stem Cell Institute, Boston, MA
³Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
⁴Maladies du Sang, Hôpital Claude Huriez, CHRU Lille, Lille, France
⁵Hematology/Oncology, Boston Children's Hospital, Boston, MA
⁶Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA

Rafael Ríos-Tamayo, MD,^1,2,3*, Juan Sáinz Pérez^1,2,3*, Manuel Jurado, MD^1,3,4, Jose Manuel Puerta Puerta, MD^1*, Pedro Antonio González Sierra, MD^1*, Antonio Romero Aguilar, MD^1*, Elisa Lopez Fernandez, MD^1*, Lucia Moratalla Lopez, MD^1*, José Luís García de Veas Silva^5*, Teresa Rodríguez Ruiz^6*, José Juan Jiménez Moleón, MD^3,7,8* and María José Sánchez Pérez, MD^3,9,10*

¹Hematology, University Hospital Virgen de las Nieves, Granada, Spain
²Genomic Oncology Area, GENYO. Centre for Genomics and Oncological Research: Pfizer /University of Granada / Andalusian Regional Government, PTS,, Granada, Spain
³Instituto de Investigación Biosanitaria de Granada (Ibs.GRANADA). Hospitales Universitarios de Granada / Universidad de Granada, Granada, Spain
⁴Genomic Oncology Area, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, Granada, Spain
⁵Department of Immunology, University Hospital Virgen de las Nieves, Granada, Spain
⁶Immunology, University Hospital Virgen de las Nieves, Granada, Spain
⁷Preventive Medicine, CIBER Epidemiology and Public Health, Granada, Spain
⁸Medicine Preventive, University of Granada, Granada, Spain
⁹Granada Cancer Registry, Andalusian School of Public Health, Granada, Spain
¹⁰Granada Cancer Registry, CIBER Epidemiology and Public Health, Granada, Spain

Chen Wang, MD^1*, Qian-qian Cai, MD^1*, Xin-xin Cao, MD^1*, Dao-bin Zhou, MD^1* and Jian Li, MD^2*

¹Hematology department, Peking Union Medical College Hospital, Beijing, China
²Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

Charlotte Pawlyn, MB BChir^1,2*, Martin F Kaiser, MD^1,2*, Lucy Fowkes, MD^3*, John R Jones, MD^1,2*, Faith E Davies, MD^2,4, Gareth J Morgan, MD, PhD^2,4, David Collins, BA, MInstP^5*, Bhupinder Sharma, MD^3*, Angela Riddell, MD^3* and Christina Messiou, MD^2,3*

¹Department of Haematology, The Royal Marsden Hospital NHS Foundation Trust, London, United Kingdom
²The Institute of Cancer Research, London, United Kingdom
³Department of Radiology, The Royal Marsden Hospital NHS Foundation Trust, London, United Kingdom
⁴Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR
⁵CRUK Cancer Imaging Centre, The Institute Of Cancer Research, and The Royal Marsden Hospital NHS Foundation Trust, London, United Kingdom

Yuko Kuroda^1*, Kei Kimura^1*, Yuta Masuda^1*, Arito Yamane^2*, Hikaru Hattori^3*, Kenichi Tahara, MD^4*, Ayaka Kaneko^1*, Itsumi Suda^1*, Noriyuki Takahashi^1*, Gotoh Nanami^1*, Kie Nagai^1*, Tomomi Nagashima^1*, Makiko Takizawa, PhD, MD^4*, Hiromi Koiso^4*, Takuma Ishizaki^4*, Takeki Mitsui^4*, Hirono Iriuchishima, MD, PhD^4*, Takayuki Saitoh, MD, PhD^1*, Hiroaki Shimizu, MD, PhD^5*, Akihiko Yokohama, MD, PhD⁶, Norifumi Tsukamoto, MD, PhD⁵, Tetsuhiro Kasamatsu^1*, Yusuke Minato, PhD^7*, Yoshihisa Nojima^4*, Hirokazu Murakami, M.D.Ph.D.¹ and Hiroshi Handa, MD, PhD⁴

¹Department of Laboratory Science, Gunma University Graduate School of Health Sciences, Gunma, Japan
²Department of Molecular Pharmacology and Oncology, Gunma University Graduate School of Medicine, Gunma, Japan
³Nagoya University Hospital, Aichi, Japan
⁴Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, Gunma, Japan
⁵Oncology Center, Gunma University Hospital, Gunma, Japan
⁶Division of Blood Transfusion Service, Gunma University Hospital, Maebashi, Japan
⁷Department of Virology and Preventive Medicine, Gunma University, Gunma, Japan

Stefania Oliva^1*, Manuela Gambella^1*, Milena Gilestro^1*, Francesca Gay^1*, Alessandra Larocca^1*, Anna Marina Liberati², Francesca Bonello^1*, Giulia Benevolo^2*, Giovannino Ciccone^3*, Tommaso Caravita^2*, Vittorio Emanuele Muccio^1*, Simona Caltagirone^1*, Stefano Spada^1*, Barbara Gamberi^2*, Simone Ferrero^2*, Marina Ruggeri^1*, Giuseppe Rossi², Elona Saraci^1*, Massimo Offidani², Maria Teresa Petrucci^2*, Mario Boccadoro, MD¹, Pieter Sonneveld, MD, PhD⁴, Antonio Palumbo¹ and Paola Omedè^1*

¹Myeloma Unit, Division of Hematology, University of Torino, Torino, Italy
²Italian Multiple Myeloma Network, GIMEMA, Italy
³Unit of Clinical Epidemiology, A.O.U. Citta' della Salute e della Scienza di Torino, Torino, Italy
⁴Department of Hematology, Erasmus MC, Rotterdam, Netherlands

Stefan Mittermayr, PhD^1*, Jonathan Bones, PhD^1*, Giao N Le, MB, BCh, BAO, MRCP^2* and Peter O'Gorman^3,4

¹National Institute for Bioprocessing Research and Training, Dublin, Ireland
²Department of Haematology, Mater Misericordiae University Hospital, Dublin, Ireland
³National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland
⁴Department of Haematology, Mater Misericordiae University Hospital, Dublin 7, Ireland

Anamika Dhyani, PhD^1*, Patricia Favaro, PhD^2* and Sara T Saad, M.D., PhD¹

¹Hematology and Hemotherapy Center-University of Campinas/Hemocentro-Unicamp, Instituto Nacional de Ciência e Tecnologia do Sangue, Campinas, Brazil
²Federal University of Sao Paulo, Diadema, Sao Paulo, Brazil

Takayuki Tabayashi, MD, PhD^*, Yasuyuki Takahashi, MD^*, Yuta Kimura, MD^*, Tatsuki Tomikawa, MD^*, Tomoe Nemoto-Anan, MD, PhD^*, Reiko Watanabe, MD, PhD^*, Michihide Tokuhira, MD, PhD^* and Masahiro Kizaki, MD, PhD

Department of Hematology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan

Masahiko Kanehira, DVM, PhD^1*, Tohru Fujiwara, MD, PhD^2*, Shinji Nakajima, MD, PhD^3*, Yoko Okitsu, MD, PhD^1*, Yasushi Ohnishi, MD, PhD^1*, Noriko Fukuhara, MD, PhD¹, Ryo Ichinohasama, MD, PhD^4* and Hideo Harigae, MD, PhD²

¹Department of Hematology and Rheumatology, Tohoku University Hospital, Sendai, Japan
²Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan
³Japanese Red Cross Ishinomaki Hospital, Ishinomaki, Japan
⁴Division of Hematopathology, Tohoku University Graduate School of Medicine, Sendai, Japan

Gergely Varga, MD^1*, Gabor Mikala, MD, PhD^2*, Gergely Szombath, MD^1*, Katalin Balassa, MD^3*, Katalin Piroska Kiss, MD^3*, Attila Tordai, PhD, DSc^4*, Hajnalka Andrikovics, MD, PhD^3* and Tamas Masszi, MD, PhD^1,2

¹Department of Internal Medicine, Semmelweis University, Budapest, Hungary
²Department of Haematology and Stem Cell Transplantation, St. Istvan and St. Laszlo Hospital, Budapest, Hungary
³Laboratory of Molecular Diagnostics, Hungarian National Blood Transfusion Service, Budapest, Hungary
⁴Institute of Pathophysiology, Semmelweis University, Budapest, Hungary

Ju Bai^1*, Aili He^1*, Wanggang Zhang^1*, Yun Yang^1*, Jianli Wang^1*, Pengyu Zhang^1*, Yuandong Feng^1*, Lei Zhang^2*, Hongli Chen^1*, Xiaman Wang^1*, Xiaoru Lei^1*, Ying Shen^1* and Lingjuan Huang^1*

¹Department of Hematology, Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China
²Department of Clinical Lab, Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China

Ying S Zou, MD, PHD^1*, Yi Huang, PHD^2*, Zhou Feng^2*, Sin Chan^3*, Shweta Shukla^4*, Ina Lee, MD, PHD^1*, Zeba Singh, MD¹, Mehmet H. Kocoglu, MD⁴, Aaron P. Rapoport, MD⁴, Ning Ma^4*, Nancy M. Hardy, MD⁴, Jean Yared, MD^4*, Maria R Baer, MD⁴ and Ashraf Z Badros, MD⁴

¹Pathology, University of Maryland School of Medicine, Baltimore, MD
²Department of Mathematics and Statistics, University of Maryland, Baltimore County, MD
³Department of Human Genetics and Genomic Medicine, University of Maryland, Baltimore, MD
⁴Department of Medicine and Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD

Gabriele Buda, MD¹, Giovanni Carulli^1*, Enrico Orciuolo^1*, Paola Sammuri^1*, Sara Galimberti, MD^2*, Martina Rousseau, MD^2*, Francesca Martini^1* and Mario Petrini¹

¹University of Pisa, Department of Clinical and Experimental Medicine, Section of Hematology, Italy, Pisa, Italy
²UO University Hematology, AOU Pisana, Pisa, Italy

Sung-Eun Lee^1*, Ji-Young Lim^1*, Da-Bin Ryu^1*, Tae Woo Kim^1*, Young-Woo Jeon^2*, Jae-Ho Yoon, M.D.^1*, Byung-Sik Cho, M.D.^3*, Ki-Seong Eom^1*, Yoo-Jin Kim^1*, Hee-Je Kim, M.D.², Seok Lee^1*, Seok-Goo Cho^1*, Dong-Wook Kim^1*, Jong Wook Lee¹, Woo-Sung Min, M.D.^2* and Chang-Ki Min^1*

¹Department of Hematology, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea
²Department of Hematology, Catholic Blood and Marrow Transplantation Center, Cancer Research Institute, Seoul St. Mary’s hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea
³Hematology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea

Salomon Manier, MD¹, Herve Avet-Loiseau^2*, Federico Campigotto, MS^3*, Karma Salem, MD^1*, Daisy Huynh, BS, MS^1*, Siobhan Glavey, MD^4*, Antonio Sacco, BS^1*, Aldo M Roccaro, MD, PhD¹, Stephane Minvielle^5*, Philippe Moreau, MD, PhD^6*, Thierry Facon⁷, Xavier Leleu, MD, PhD⁷, Edie A. Weller, PhD^3* and Irene M. Ghobrial, MD⁸

¹Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
²IUCT-Oncopole, Toulouse, France
³Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA
⁴Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
⁵Centre Hospitalier Universitaire de Nantes, Unité Mixte de Genomique du Cancer, Nantes, France
⁶Nantes University Hospital, Hôtel Dieu, Nantes, France
⁷Maladies du Sang, Hôpital Claude Huriez, CHRU Lille, Lille, France
⁸Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA

Julie Devin^1*, Elena Viziteu^1*, Laurie Herviou^1*, Anja Seckinger, MD^2*, Grandmougin Camille^1*, Hartmut Goldschmidt, MD³, Laure Vincent, MD^4*, Philippe Pasero, PhD^1*, Dirk Hose, MD², Bernard Klein, PhD⁵ and Jerome Moreaux, PhD^6*

¹Institute of Human Genetics, CNRS UPR 1142, Montpellier, France
²Medizinische Klinik V, Universitätsklinikum Heidelberg, Heidelberg, Germany
³Internal Medicine V, University Clinic Heidelberg, Heidelberg, Germany
⁴Department of Clinical Haematology, CHU Montpellier, Montpellier, France
⁵Department of Biological Hematology, Laboratory for Monitoring Innovative Therapies, University Hospital of Montpellier, Montpellier, France
⁶CNRS UPR 1142, Institute of Human Genetics, Montpellier, France

Jahangir Abdi, PhD,^1,2*, Yijun Yang, PhD^1,2*, Patrick Meyer-Erlach^1,2* and Hong Chang, MD, PhD^1,2

¹University of Toronto, Department of Laboratory Medicine and Pathobiology, Toronto, ON, Canada
²University Health Network, Department of Laboratory Hematology, Toronto, ON, Canada

Paolo Milani, MD^*, Andrea Foli, MD^*, Marco Basset, MD^*, Giovanni Palladini, MD, PhD and Giampaolo Merlini, MD

Amyloidosis Research and Treatment Center, University of Pavia and Fondazione IRCCS Policlinico San Matteo, Pavia, Italy

Paolo Milani, MD^1,2*, Angela Dispenzieri, MD², Morie A. Gertz, MD², Martha Q. Lacy, MD², Francis K. Baudi^2*, Shaji K. Kumar, MD², Mathew S. Maurer, MD^3*, Kyle Klarich^4*, Suzanne R. Hayman, MD², Nelson Leung, MD⁵, David Dingli, MD, PhD², John A. Lust, MD, PhD², Yi Lin, MD, PhD², Prashant Kapoor, MD², Ronald S. Go, MD², Yi L. Hwa, NP^2*, Steven R. Zeldenrust, MD, PhD², Robert A. Kyle, MD², S. Vincent Rajkumar² and Martha Grogan, MD^4*

¹Amyloidosis Research and Treatment Center, University of Pavia and Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
²Division of Hematology, Mayo Clinic, Rochester, MN
³Division of Cardiology, Columbia University, New York, NY
⁴Division of Cardiology, Mayo Clinic, Rochester, MN
⁵Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN

Stefan Mittermayr, PhD^1*, Jonathan Bones, PhD^1*, Giao N Le, MB, BCh, BAO, MRCP^2* and Peter O'Gorman^3,4

¹National Institute for Bioprocessing Research and Training, Dublin, Ireland
²Department of Haematology, Mater Misericordiae University Hospital, Dublin, Ireland
³Department of Haematology, Mater Misericordiae University Hospital, Dublin 7, Ireland
⁴National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland

Supakanya Wongrakpanich, MD¹, Gemlyn George, MBBS^1*, Wikrom Chaiwatcharayut, MD.^1*, Nellowe Candelario, MD^1*, Varun Mittal, MD^2*, Sherry Pomerantz, PhD^1* and Gabor Varadi, MD²

¹Department of Medicine, Einstein Medical Center, Philadelphia, PA
²Division of Hematology/Oncology, Einstein Medical Center, Philadelphia, PA

Sarah Waheed, MD^1*, Hongwei Wang^2*, Pingping Qu, PhD^2*, Christoph Heuck, MD¹, Aasiya Matin^1*, Yogesh Jethava, MB, MRCP, MD, FRCPath¹, Frits van Rhee, MD, PhD¹, Antje Hoering^2*, Bart Barlogie, MD, PhD¹, Faith E Davies, MD¹ and Gareth J Morgan, MD PhD¹

¹Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR
²Cancer Research and Biostatistics, Seattle, WA

Suzie Vardanyan, MS^1*, Kirsten Meid, MPH^2*, Kyle A Udd, BA^3*, James Wang, MD^3*, Mingjie Li, BS^1*, Eric Sanchez, BA^1*, Cathy Wang, BS^1*, Abigail Gillespie^1*, Maya Spitzer^3*, Tanya M. Spektor, PhD^4*, Anna Shvartsur^1*, Nika Manik Harutyunyan^3*, Gigi Garzio^1*, George Tang, PhD^1*, Haiming Chen, MD, PhD¹, Steven P Treon, MD, PhD² and James Berenson, MD^1,3,4

¹Institute for Myeloma & Bone Cancer Research, West Hollywood, CA
²Bing Center for WM, Dana Farber Cancer Institute, Boston, MA
³James R. Berenson, MD, Inc., West Hollywood, CA
⁴Oncotherapeutics Inc., Los Angeles, CA

Peter Mollee, MBBS, MMedSc, FRACP, FRCPA^1,2,3, Patricia Renaut, MBBS, FRCPA^4,5*, Samuel Boros, MBBS, FRCPA^4,5*, Dorothy Loo, MSc^2,5,6* and Michelle Hill, PhD, BSc (Hon), BA^2,5,6*

¹Princess Alexandra Hospital, Brisbane, Australia
²Translational Research Institute, Brisbane, Australia
³School of Medicine, University of Queensland, Brisbane, Australia
⁴Princess Alexandra Hospital, Pathology Queensland, Brisbane, Australia
⁵Amyloidosis Centre, Princess Alexandra Hospital, Brisbane, Australia
⁶University of Queensland Diamantina Institute, Brisbane, Australia

David L Murray, MD, PhD^1*, John R. Mills, Ph.D.^2*, Maria Alice V Willrich, PhD^1*, David Barnidge, Ph.D.^3*, Mindy C Kohlhagen^3* and Angela Dispenzieri, MD⁴

¹Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
²Departmetn of Laboratory Medicine, Mayo Clinic, Rochester, MN
³Laboratory Medicine, Mayo Clinic, Rochester, MN
⁴Division of Hematology, Mayo Clinic, Rochester, MN

Narayanan Bhagavathi, PHD^1*, Blau Talia, BA^2*, Nicole Adell Doudican, PhD^3*, Narayanan Narayanan, PHD^4* and Amitabha Mazumder, M.D.⁵

¹Medicine, NYU School of Medicine, New York, NY
²Environmental Medicine, NYU Graduate School, New York, NY
³Dermatology, NYU School of Medicine, New York, NY
⁴Environmental Medicine, NYU School of Medicine, New York, NY
⁵Medicine, NYU Perlmutter Cancer Center, NY, New York, NY

Rachel K Wee^1*, Hiroyuki Takamatsu, MD, PhD¹, Ryoichi Murata, MD^2*, Jianbiao Zheng, PhD^3*, Martin Moorhead, PhD^3*, Naoki Takezako, MD, PhD⁴, Shigeki Ito, MD, PhD⁵, Toshihiro Miyamoto, MD, PhD⁶, Kenji Yokoyama, MD, PhD⁷, Kosei Matsue, MD, PhD⁸, Tsutomu Sato, MD, PhD^9*, Toshiro Kurokawa, MD, PhD^10*, Hideo Yagi, MD, PhD¹¹, Yasushi Terasaki, MD, PhD^12*, Kinya Ohata, MD, PhD^1*, Takashi Yoshida, MD, PhD^13*, Malek Faham, MD, PhD³ and Shinji Nakao, MD, PhD¹

¹Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
²Keiju Kanazawa Hospital, Kanazawa, Japan
³Adaptive Biotechnologies Corp, South San Francisco, CA
⁴Department of Hematology, National Hospital Organization Disaster Medical Center of Japan, Tachikawa, Japan
⁵Department of Medical Oncology, Iwate Medical University School of Medicine, Morioka, Japan
⁶Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
⁷Department of Hematology/Oncology, Tokai University Hachioji Hospital, Hachioji, Japan
⁸Department of Hematology/Oncology, Kameda Medical Center, Kamogawa, Japan
⁹Department of Medical Oncology and Hematology, Sapporo Medical University School of Medicine, Sapporo, Japan
¹⁰Department of Hematology, Toyama Red Cross Hospital, Toyama, Japan
¹¹Department of Hematology, Kinki University School of Medicine Nara Hospital, Ikoma, Japan
¹²Division of Internal Medicine, Toyama City Hospital, Toyama, Japan
¹³Shizuoka City Shimizu Hospital, Shizuoka, Japan

Larysa Sanchez, MD¹, Michael Sylvester^2*, Yucai Wang, MD, PhD¹, Shijia Zhang, MD, PhD¹, Jean Eloy, MD, FACS^3*, Neil Kothari, MD^2* and Victor Chang, MD^4*

¹Department of Medicine, Rutgers New Jersey Medical School, Newark, NJ
²Rutgers New Jersey Medical School, Newark, NJ
³Rutgers New Jersey Medical School, Newarl, NJ
⁴Section of Hematology/Oncology, VA New Jersey Health Care System, East Orange, NJ

Xiaoqi Qin, MD.^1*, Gang An, MD.PhD^1*, Lin-ping Hu, MD.^2*, Yu Qin, MD, PhD^3*, Yan Xu, MD, PhD^1,4*, Xiaoyan Feng^1*, Meirong Zang^1*, Shuhui Deng, MD, PhD^3*, Weiwei Sui, MD^3*, Shuhua Yi, MD, PhD^5*, Zengjun Li Sr.^6*, Lin-hua Yang, MD.^7*, Tao Cheng, MD⁸, Jianxiang Wang, MD⁹ and Lugui Qiu, MD, PhD¹⁰

¹State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, China
²State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin 300020, China., Tianjin, China
³State Key Lab of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, China
⁴lymphoma & myeloma department, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, China
⁵State Key Lab of Experimental Hematology,Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, China
⁶State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
⁷Department of Hematology, the Second Hospital of Shanxi Medical University, Taiyuan 030001, China, Taiyuan, China
⁸Institute of Hematology & Blood Diseases Hospital, State Key Laboratory of Experimental Hematology, Tianjin, China
⁹The State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, CAMS &PUMC, Tianjin, China
¹⁰State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Tianjin, China

Gasmi Billel, MD^1*, Eric L Smith, MD, PhD^2,3, Ahmet Dogan, MD, PhD⁴, Meier Hsu, MS^5*, Sean Devlin, PhD^5*, Janine D. Pichardo, BS^4*, David J Chung, MD PhD^3,6, Guenther Koehne, MD PhD^3,6, Neha S Korde, MD^2,3, Heather J Landau, MD^2,3,6, Sergio A. Giralt, MD^6,7, Ola Landgren, MD, PhD^2,8, Hani Hassoun, MD^2,3 and Alexander M. Lesokhin, MD^1,2,3

¹Ludwig Collaborative Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY
²Department of Medicine, Myeloma Service, Memorial Sloan Kettering Cancer Center, New York, NY
³Weill Cornell Medical College, New York, NY
⁴Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY
⁵Department of Biostatistics and Epidemiology, Memorial Sloan Kettering Cancer Center, New York, NY
⁶Department of Medicine, Adult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY
⁷Weill Cornell Medical College, Cornell University, New York, NY
⁸Department of Medicine, Weill Cornell Medical College, New York, NY

Heather Landau, MD^1,2, Raymond L. Comenzo, MD³, Tasneem Balasinorwala, BS^4*, Melissa Warner, BS^3*, Ola Landgren, MD, PhD⁵, Sergio A. Giralt, MD^6,7 and Hani Hassoun, MD^2,5

¹Myeloma Service, Division of Hematologic Oncology, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY
²Weill Cornell Medical College, New York, NY
³Division of Hematology/Oncology, John C. Davis Myeloma and Amyloid Program, Tufts Medical Center, Boston, MA
⁴Memorial Sloan Kettering Cancer Center, New York, NY
⁵Department of Medicine, Myeloma Service, Memorial Sloan Kettering Cancer Center, New York, NY
⁶Weill Cornell Medical College, Cornell University, New York, NY
⁷Department of Medicine, Adult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY

Beatriz Martin-Antonio, PhD^1*, Erica Serrano^1*, Guillermo Suñe, PhD^2*, Lorena Perez^3*, Marcos Calderón^4*, Jose María Estanyol, PhD^5*, Amer Najjar, PhD^6*, Clara Bueno, PhD^7*, Carlos Fernandez de Larrea^8* and Alvaro Urbano-Ispizua, MD, PhD⁹

¹University of Barcelona/Hospital Clinic/IDIBAPS/Josep Carreras Leukaemia Research Institute, Barcelona, Spain
²University of Barcelona,/Hospital Clinic/IDIBAPS/Josep Carreras Leukaemia Research Institute, Barcelona, Spain
³University Autonoma of Barcelona, IDIBAPS, Barcelona, Spain
⁴University of Barcelona/Hospital Clinic/IDIBAPS, Barcelona, Spain
⁵University of Barcelona/Facultat de Medicina, Barcelona, Spain
⁶The University of Texas M.D. Anderson Cancer Center. Department of Cancer Systems Imaging, Houston, TX
⁷University of Barcelona/Josep Carreras Leukaemia Research Institute, Barcelona, Spain
⁸Hospital Clínic de Barcelona, IDIBAPS, Barcelona, Spain
⁹Institute of Research Josep Carreras, Hospital Clinic, University of Barcelona, Barcelona, Spain

Hiroyuki Takamatsu¹, Ryoichi Murata, MD^2*, Jianbiao Zheng^3*, Martin Moorhead^3*, Naoki Takezako⁴, Shigeki Ito, MD, PhD⁵, Toshihiro Miyamoto, MD, PhD⁶, Kenji Yokoyama⁷, Kosei Matsue, MD, PhD⁸, Tsutomu Sato, MD, PhD^9*, Toshiro Kurokawa, MD, PhD^10*, Hideo Yagi¹¹, Yasushi Terasaki, MD, PhD^12*, Kinya Ohata, MD, PhD^1*, Takashi Yoshida, MD, PhD^13*, Malek Faham, MD, PhD³ and Shinji Nakao, MD, PhD¹

¹Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
²Keiju Kanazawa Hospital, Kanazawa, Japan
³Adaptive Biotechnologies Corp, South San Francisco, CA
⁴Department of Hematology, National Hospital Organization Disaster Medical Center of Japan, Tachikawa, Japan
⁵Department of Medical Oncology, Iwate Medical University School of Medicine, Morioka, Japan
⁶Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
⁷Department of Hematology/Oncology, Tokai University Hachioji Hospital, Hachioji, Japan
⁸Division of Hematology/Oncology, Department of Medicine, Kameda Medical Center, Kamogawa, Japan
⁹Department of Medical Oncology and Hematology, Sapporo Medical University School of Medicine, Sapporo, Japan
¹⁰Department of Hematology, Toyama Red Cross Hospital, Toyama, Japan
¹¹Department of Hematology, Kinki University School of Medicine, Nara Hospital, Ikoma, Nara, Japan
¹²Division of Internal Medicine, Toyama City Hospital, Toyama, Japan
¹³Shizuoka City Shimizu Hospital, Shizuoka, Japan

Michael D. Amatangelo, PhD^1*, Paola Neri, MD, PhD^2,3, Maria Ortiz, PhD^4*, Chad C. Bjorklund¹, Anita K. Gandhi, PhD^1*, Anke Klippel¹, Nizar J Bahlis, MD², Tom Daniel^5*, Rajesh Chopra, MBBS, PhD¹, Matthew Trotter^6* and Anjan Thakurta^1*

¹Celgene Corporation, Summit, NJ
²University of Calgary, Southern Alberta Cancer Research Institute, Calgary, AB, Canada
³University of Calgary, Division of Hematology, Calgary, AB, Canada
⁴Celgene Institute for Translational Research Europe, Celgene Corporation, Seville, Spain
⁵Celgene Corporation, San Diego, CA
⁶Celgene Corporation, Sevilla, Spain

Tobias Dittrich, MD^1*, Ute Hegenbart, MD^1*, Tilmann Bochtler, MD^1*, Christoph Kimmich, MD^1*, Anna Jauch, Prof.^2*, Arnt Kristen, MD^3*, Hartmut Goldschmidt, MD⁴, Anthony D. Ho, MD⁵ and Stefan Schönland, MD^6*

¹Amyloidosis Center, University Hospital Heidelberg, Heidelberg, Germany
²Institute of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany
³Medical Dept. / Cardiology, University Hospital Heidelberg, Heidelberg, Germany
⁴Internal Medicine V, University Clinic Heidelberg, Heidelberg, Germany
⁵Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany
⁶Amyloidosis Center, Department of Internal Medicine V, Division of Hematology/Oncology/Rheumatology, University of Heidelberg, Heidelberg, Germany

Hanna Radomska^1*, Alessandro Canella^2*, Consiglio Jessica^2*, Alberto Rocci, MD^3*, Cascione Luciano^4*, Hector Cordero^2*, Liu Joseph^1*, Enrico Caserta^2*, Santhanam Ramasamy^2*, Yvonne A. Efebera, MD, MPH⁵, Stefano Volinia, PhD⁶, Craig C Hofmeister, MD, MPH⁷ and Flavia Pichiorri, PhD⁸

¹The Ohio State University, Columbus
²The Ohio state University, Columbus
³A.O.U. San Giovanni Battista, Manchester, England
⁴Institute of Oncology Research (IOR), Bellinzona, Switzerland
⁵Comprehensive Cancer Center, The Ohio State University, Columbus, OH
⁶Ohio State University, Columbus, OH
⁷Department of Internal Medicine, Division of Hematology, The Ohio State University, Columbus, OH
⁸Internal medicine, The Ohio State University, Columbus, OH

Charlotte Pawlyn, MB BChir^1*, Tim Chambers^1*, Veronica Macleod^2*, Daniel Sappington^3*, Amy Buros, PhD^2*, Caleb K. Stein, MS^2*, Martin F Kaiser, MD^1*, Rosemary Burke^1*, Swen Hoelder^1*, Gunnar Boysen^3*, Ricky D Edmondson, Ph.D.^2*, Gareth J Morgan, MD, PhD^1,2 and Faith E Davies, MD^1,2

¹The Institute of Cancer Research, London, United Kingdom
²Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR
³Department of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock

Satoshi Takagi, PhD¹, Shokichi Tsukamoto, MD, PhD¹, Yawara Kawano, MD, PhD^1*, Michele Moschetta, MD^1*, Yuji Mishima, PhD^1*, Katsutoshi Kokubun, PhD^1*, Salomon Manier, MD¹, Karma Salem, MD^1*, Daisy Huynh, BS, MS^1*, Antonio Sacco, BS^1*, Aldo M Roccaro, MD, PhD¹, Kelly Elizabeth Johnson, PhD^2*, Elisabeth M. Battinelli, MD, PhD² and Irene M. Ghobrial, MD¹

¹Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
²Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

Fred Gruber, PhD^1*, Boris Hayete, PhD^1*, Jonathan J Keats, Ph.D.², Kyle McBride, MS^3*, Runge Karl, PhD^1*, Mary Derome, MS^4*, Sagar Lonial, MD⁵, Iya Khalil, PhD^1* and Daniel Auclair, PhD^4*

¹GNS Healthcare, Cambridge, MA
²Translational Genomics Research Institute, Phoenix, AZ
³Instat Services, Chatham, NJ
⁴Multiple Myeloma Research Foundation, Norwalk, CT
⁵Winship Cancer Institute of Emory University, Department of Hematology and Medical Oncology, Atlanta, GA

K Martin Kortuem^1*, Esteban Braggio¹, Pieter Sonneveld, MD, PhD², Laura Ann Bruins^1*, Santiago Barrio^1*, Davine Hofste op Bruinink^3*, Mark vanDuin^3*, Elias Karl Mai, MD^4*, Nur Hanafiah^4*, Hartmut Goldschmidt, MD^4,5, Sanchin Pathangey^1*, Yanira Ruiz Heredia^6*, Inmaculada Rapado^6*, Beatriz Sanchez-Vega^6*, Stefan Knop^7*, Leo Rasche^7*, Christian Langer⁸, Miriam Kull^8*, Lars Bullinger⁸, Monika Engelhardt⁹, Joaquin Martinez-Lopez^6*, Hermann Einsele¹⁰, Marc S. Raab⁴ and A. Keith Stewart^1,11

¹Mayo Clinic, Scottsdale, AZ
²Department of Hematology, Erasmus MC, Rotterdam, Netherlands
³Erasmus Medical Center, Rotterdam, The Netherlands, Rotterdam, Netherlands
⁴Internal Medicine V, University Clinic Heidelberg, Heidelberg, Germany
⁵National Center for Tumor Diseases (NCT) Heidelberg, University Hospital Heidelberg, Heidelberg, Germany
⁶Hospital-12-de-Octubre, Madrid, Spain
⁷Department of Internal Medicine. II, Wuerzburg, Germany
⁸Department of Internal Medicine III, Ulm, Germany
⁹Department of Internal Medicine I, Freiburg, Germany
¹⁰2Department of Internal Medicine. II, Wuerzburg, Germany
¹¹Oncospire Genomics Inc., Rochester, MN

Rebecca Silbermann, MD¹, Juraj Adamik, PhD^2*, Dan Zhou^1*, Xiang-Qun Xie, MD, PhD, EMBA^3*, G. David Roodman, MD, PhD^1,4, Noriyoshi Kurihara, DDS, PhD¹ and Deborah Lynn Galson, PhD²

¹Medicine/Hematology-Oncology, Indiana University, Indianapolis, IN
²Department of Medicine, Hematology-Oncology, University of Pittsburgh, Pittsburgh Cancer Institute, Pittsburgh, PA
³Department of Pharmaceutical Sciences/Drug Discovery Institute, University of Pittsburgh, School of Pharmacy, Pittsburgh, PA
⁴Richard L. Roudenbush Veterans Administration Medical Center, Indianapolis, IN

Timothy N Trotter^1*, Tshering D Lama-Sherpa^1*, Deniz Peker, MD^1*, Amjad Javed^2,3*, Larry J Suva^4* and Yang Yang^1,3

¹Department of Pathology, University of Alabama at Birmingham, Birmingham, AL
²Department of Oral and Maxillofacial Surgery, School of Dentistry, University of Alabama at Birmingham, Birmingham, AL
³Comprehensive Cancer Center and the Center for Metabolic Bone Disease, University of Alabama at Birmingham, Birmingham, AL
⁴Department of Orthopaedic Surgery, Center for Orthopaedic Research,, University of Arkansas for Medical Sciences, Little Rock, AR