Roopa Taranath, PhD^1*, Gregory Bourne, PhD^2*, Jie Zhang, PhD^2*, Brian Frederick, MS^1*, Tran T Tran, PhD^2*, Ashok Bhandari, PhD^1*, Jayanthi Vengalam, MS^1*, Jaimee McMahon^2*, Keith Huie, MS^1*, Grace A Ledet, MS^1*, Li Zhao, MD, PhD^1*, James Tovera^1*, Larry Lee^1*, Bo Yang, PhD^1*, Celino Dion^1*, Lucy Yuan^1*, Genet Zemede, MS^1*, Michelle Nguyen^1*, Mohammad Masjedizadeh, PhD^1*, Xiaoli Cheng, PhD^1*, Larry Mattheakis, PhD^1*, David Liu, PhD^1* and Mark L Smythe, PhD^2*

¹Protagonist Therapeutics, Newark, CA
²Protagonist Therapeutics Pty Ltd, Brisbane, QLD, Australia

Richi Kashyap, MD^1*, Muhammad Ashar Ali, MD^2*, Saad Ullah Malik, MD^3*, Farhan Khalid, MBBS^2*, Ali Jaan, MD^2*, Awais Khalid, MBBS^2*, Abdul Jabbar Dar, MD^4*, Qasim Khurshid, MD^5*, Karun Neupane, MBBS, MD^6*, Mobeen Zaka Haider, MD, MBBS^2*, Syed Maaz Abdullah, MBBS^2* and Faiz Anwer, MD⁷

¹Maulana Azad Medical College, New Delhi, India
²King Edward Medical University, Lahore, Pakistan
³Department of Internal Medicine, Joan C. Edward School of Medicine, Huntington
⁴Shaikh Zayed Medical College, Lahore, Pakistan
⁵Xinjiang medical university, Urumqi, China
⁶Manipal College of Medical Sciences, Pokhara, Nepal
⁷Taussig Cancer Institute, Cleveland Clinic, Cleveland

Roopa Taranath, PhD^*, Larry Mattheakis, PhD^*, Li Zhao, MD, PhD^*, Larry Lee^*, James Tovera^*, Jingsong Zhao, PhD^*, Xiaoli Cheng, PhD^* and David Liu, PhD^*

Protagonist Therapeutics, Newark, CA

Manisha Balwani^1*, Herbert L. Bonkovsky, MD^2*, Kirstine J Belongie, PhD^3*, Karl E Anderson, MD^4*, Fumihiro Takahashi, PhD^5*, Antonio Irizarry, MBA^6*, Mark Amster, MD^7*, D. Montgomery Bissell, MD^8*, Bruce Wang, MD^9*, Lydie Hazan, MD^10*, Charles J. Parker, MD¹¹, Edward Cordasco, MD^12*, Cynthia Levy, MD^13* and Robert J. Desnick, MD, PhD^14*

¹Icahn School of Medicine at Mount Sinai, New York
²University of Connecticut, Farmington, CT
³Mitsubishi Tanabe Pharma Development America, Jersey city, NJ
⁴University of Texas Medical Branch, Galveston
⁵Mitsubishi Tanabe Pharma Cooperation, Tokyo, Japan
⁶Mitsubishi Tanabe Pharma Development America, Jersey city
⁷Dermatology Associates Rogers Outpatient Center, Mashpee
⁸UCS, San Francisco, CA
⁹University of California, san francisco
¹⁰Axis Clinical Trials, Los Angeles
¹¹University of Utah School of Medicine, Salt Lake City, UT
¹²Remington Davis clinical research, Columbus
¹³University of Miami, Miami
¹⁴Mount Sinai School of Medicine, New York, NY

Nicole Ursula Stoffel, PhD^1*, Michael Bruce Zimmermann, MD^1*, Ana Carla Cepeda Lopez, MD^2*, Karla I Cervantes Gracia, Msc^2*, Elida E Lee Bazaldua, Msc^2*, Zeder Christophe, Msc^1*, Katharina Quack-Loetscher, MD^3*, Sueppong Gowachirapant, PhD^4* and Isabelle Herter-Aeberli, PhD^1*

¹Human Nutrition Laboratory, ETH Zurich, Zurich, Switzerland
²Universidad de Monterrey, Monterrey, Mexico
³Obstetric hospital, University hospital, Zurich, Switzerland
⁴Mahidol University, Bangkok, Thailand

Fayuan Wen, Ph.D^1,2*, Angela Rock^2,3*, Juan Salomon-Andonie, MS^3,4*, Gulriz Kurban, Ph.D^2,3*, Xiaomei Niu, MD^4*, Songping Wang^5*, Xu Zhang, PhD^3,6*, Victor R. Gordeuk, MD^3,7, Yingze Zhang, Ph.D^8*, Seyed Mehdi Nouraie, PhD, MD^3,8, Mark T. Gladwin, MD^3,9, Allison Ashley-Koch, PhD^10*, Marilyn J. Telen, MD^11,12, Brian Custer, Ph.D^1,13*, Shannon Kelly^3,13*, Carla Luana Dinardo, Ph.D^3,14,15*, Ester Sabino^3,15*, Quenna Wong^16*, James G. Taylor, MD^3,4 and Sergei Nekhai, PhD^3,17

¹NHLBI Trans-Omics for Precision Medicine (TOPMed) Sickle Cell Disease Working Group, Washington, DC
²Center for Sickle Cell Disease, Department of Medicine, Howard University, Washington, DC
³NHLBI Trans-Omics for Precision Medicine (TOPMed) Sickle Cell Disease Working Group, Washington
⁴Center for Sickle Cell Disease, Howard University, Washington, DC
⁵Center for Sickle Cell Disease, Howard University, Washington DC, DC
⁶University of Illinois At Chicago, Chicago, IL
⁷Sickle Cell Center, Division of Hematology and Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, IL
⁸Department of Medicine, University of Pittsburgh, Pittsburgh, PA
⁹University of Pittsburgh, Pittsburgh, PA
¹⁰Department of Medicine, Duke University Medical Center, Durham, NC
¹¹Duke Univ. Med. Ctr., Durham, NC
¹²NHLBI Trans-Omics for Precision Medicine (TOPMed) Sickle Cell Disease Working Group, Washinton
¹³Vitalant Research Institute, San Francisco, CA
¹⁴Fundação Pró-Sangue, São Paulo Hemocenter, Sao Paolo, Brazil
¹⁵Institute of Tropical Medicine of São Paulo, Sao Paolo, Brazil
¹⁶Department of Biostatistics, University of Washington, Seattle, WA
¹⁷Center for Sickle Cell Disease and Department of Medicine, Howard University, Washington, DC

Hsi-Che Liu, MD¹, Ting-Chi Yeh, MD^1*, Jen-Yin Hou, MD^1*, Ting-Huan Huang, MD^1*, Chia-Yu Sung, MD^2*, Chun-Hui Lin, MS^3*, Syuan-You Ye, MS^4* and Tsai-Ying Chen, MS^4*

¹Mackay Children's Hospital and Mackay Medical College, Taipei, Taiwan
²Changhua Christian Children's Hospital, Changhua City, Taiwan
³Mackay Children's Hospital, Taipei, Taiwan
⁴Mackay Memorial Hospital, Taipei, Taiwan

Brian MacDonald, PhD, MBBChir, MRCP^*, Cecile Blaustein, PhD^*, Sophia Nguyen, MS^*, Christopher King, PhD, MBA^*, Vu Hong, PhD^*, Will Savage, MD, PhD, Srikanth Venkatraman, PhD^* and Maria G. Beconi, PhD, MS^*

Disc Medicine, Cambridge, MA