Antonio Risitano, MD, PhD¹, Jun-Ho Jang, MD^2*, Lee Gyeong-Won^3*, Wanchai Wanachiwanawin^4*, Hubert Schrezenmeier⁵, Yuji Yonemura, MD, PhD⁶, Talha Munir, MBBS^7*, Rodrigo Pavani^8*, Jimmy Wang^9*, Alexander D. Kulagin, MD, PhD^10*, Austin G Kulasekararaj, MD, MBBS, MRCP, FRCPath¹¹, Flore Sicre de Fontbrune^12* and Alexander Röth, MD¹³

¹Department of Clinical Medicine and Surgery, University of Naples, Naples, Italy
²Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea, Republic of (South)
³Division of Hematology and Oncology Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University College of Medicine, Jinju, Korea, Republic of (South)
⁴Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
⁵Institute of Transfusion Medicine, University of Ulm, Ulm, Germany, and Institute for Clinical Transfusion Medicine and Immunogenetics, German Red Cross Blood Transfusion Service Baden-Württemberg-Hessen, and University Hospital Ulm, Ulm, Germany
⁶Kumamoto University School of Medicine, Kumamoto, Japan
⁷St James University Hospital, Leeds, United Kingdom
⁸Alexion Pharmaceuticals Inc., Boston, MA
⁹Alexion Pharmaceuticals, Inc., Boston, MA
¹⁰RM Gorbacheva Research Institute, Pavlov University, St. Petersburg, Russian Federation
¹¹King’s College Hospital, National Institute of Health Research/Wellcome King’s Clinical Research Facility, London, United Kingdom
¹²Centre de Référence Aplasie Médullaire, Service d’Hématologie Greffe, Assistance Publique des Hôpitaux de Paris, Hôpital Saint-Louis, Paris, France
¹³Department of Hematology, University Hospital Essen, Essen, Germany

Honglei Wang^1*, Rong Fu, PhD^1*, Hui Liu^2*, Zhaoyun Liu^1*, Liyan Li^1*, Yingying Chen^1* and Zonghong Shao, PhD²

¹Tianjin Medical University General Hospital, Tianjin, China
²Department of Hematology, Tianjin Medical University General Hospital, Tianjin, China

Carmelo Gurnari, MD^1,2*, Simona Pagliuca, MD^1,3, Bhumika J. Patel, MD⁴, Hassan Awada, MD¹, Cassandra M Kerr, MS^1*, Sunisa Kongkiatkamon, MD^1*, Laila Terkawi^1*, Misam Zawit, MBBS^1*, Valeria Visconte, PhD¹, Adam Wahida^5* and Jaroslaw P. Maciejewski, MD, PhD⁶

¹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
²Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
³Université de Paris, Paris, France
⁴Leukemia Program, Department of Hematology and Medical Oncology, Cleveland Clinic, Cleveland, OH
⁵MLL Munich Leukemia Laboratory, Munich, Germany
⁶Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH

Kelsey Temprine, PhD^*, Amanda Sankar, MD^*, Costas Lyssiotis, PhD^* and Yatrik Shah, PhD^*

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI

Peter Hillmen, MBChB, PhD^1*, Jeffrey Szer, MBBS², Ilene C. Weitz³, Alexander Röth, MD⁴, Britta Hoechsmann^5*, Jens Panse, MD⁶, Kensuke Usuki, MD, PhD⁷, Morag Griffin, MBChB, FRCPath^1*, Jean-Jacques Kiladjian, MD, PhD^8*, Carlos M. de Castro, MD⁹, Hisakazu Nishimori, MD, PhD^10*, Lisa Tan^11*, Mohamed Hamdani^12*, Pascal Deschatelets, PhD^12*, Cedric Francois, MD, PhD^12*, Federico Grossi, MD^12*, Antonio Risitano, MD, PhD¹³ and Regis Peffault De Latour, MD, PhD^14*

¹Department of Haematology, St James University Hospital, Leeds, United Kingdom
²Department of Clinical Haematology, Royal Melbourne Hospital, Melbourne, VIC, Australia
³Jane Anne Nohl Division of Hematology, Keck-USC School of Medicine, Los Angeles, CA
⁴Department of Hematology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
⁵University of Ulm and Institute of Clinical Transfusion Medicine and Immunogenetics, German Red Cross Blood Transfusion Service and University Hospital Ulm, Institute of Transfusion Medicine, Ulm, Germany
⁶Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, University Hospital RWTH Aachen, Aachen, Germany
⁷Department of Hematology, NTT Medical Center Tokyo, Tokyo, Japan
⁸Centre d'Investigations Cliniques, Hôpital Saint-Louis; Assistance Publique – Hôpitaux de Paris; Université de Paris, Paris, France
⁹Duke University School of Medicine, Durham, NC
¹⁰Department of Hematology and Oncology, Okayama University Hospital, Okayama, Japan
¹¹Lisa Tan Pharma Consulting Ltd, Cambridge, United Kingdom
¹²Apellis Pharmaceuticals, Inc., Waltham, MA
¹³Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, Italy
¹⁴French Reference Center for Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria, Assistance Publique – Hôpitaux de Paris, Université de Paris, Paris, France

Minke A.E. Rab, MD^1,2*, Birgit Van Dooijeweert, MD^3*, Jennifer Bos^4*, Brigitte A. van Oirschot^5*, Penelope A. Kosinski, MS^6*, Annette van Wesel^7*, Stephanie van Straaten, MD, PhD^8*, Roger Schutgens, MD, PhD, MSc^9*, Marije Bartels, MD, PhD^10*, Paola Bianchi, BSc, PhD¹¹, Lenny Dang, PhD^6*, Charles Kung, PhD^6*, Eduard van Beers, MD, PhD^12* and Richard van Wijk, PhD^5*

¹Van Creveldkliniek, UMC Utrecht, Utrecht University, Utrecht, Netherlands
²Department of Central Diagnostic Laboratory Research, University Medical Center Utrecht, Utrecht University, Utrecht, Utrecht, Netherlands
³Laboratory of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, Utrecht, Netherlands
⁴Department of Central Diagnostic Laboratory-Research, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
⁵Department of Central Diagnostic Laboratory-Research, UMC Utrecht, Utrecht University, Utrecht, Netherlands
⁶Agios Pharmaceuticals, Inc., Cambridge, MA
⁷Central Diagnostic Laboratory-Research, UMC Utrecht, Utrecht University, UMC Utrecht, Utrecht, Netherlands
⁸Sophia Children’s Hospital, Erasmus Medical Center, Rotterdam, Netherlands
⁹Van Creveldkliniek, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
¹⁰Van Creveldkliniek, University Medical Center, Utrecht University, Utrecht, Netherlands
¹¹Ospedale Maggiore Policlinico di Milano, Foundation IRCCS Ca' Granda,, Milano, Italy
¹²Van Creveldkliniek, University Medical Center Utrecht, University of Utrecht, Utrecht, Netherlands

Rachel Y Bhak, MS^1*, Nikita Mody-Patel, PharmD, MBA^2*, Scott B. Baver, PhD^2*, Colin Kunzweiler, PhD, MS^1*, Christopher Yee, ScM^1*, Sanjana Sundaresan, ScM^1*, Natalia Swartz, MPH^1*, Mei Sheng Duh, ScD, MPH¹, Sangeeta Krishnan, PharmD, MS^2* and Sujata P. Sarda, PhD^2*

¹Analysis Group, Boston, MA
²Apellis Pharmaceuticals, Inc., Waltham, MA

Marina Feigenson, PhD^1*, Remya Nathan^2*, Keith Babbs^2*, Christopher Materna^2*, Claire C Tseng, PhD^2*, Ffolliott Fisher^2*, Jasbir Seehra^2* and Jenn Lachey^2*

¹Keros Therapeutics, Brighton, MA
²Keros Therapeutics, Lexington, MA

Rachael F. Grace, MD¹, Audra Boscoe, PhD^2*, Chris Bowden, MD^2*, Bertil Glader, MD, PhD³, Hitoshi Kanno, MD, PhD⁴, D. Mark Layton, MB BS^5*, Eduard van Beers, MD, PhD^6*, Joan-Lluis Vives Corrons, MD, PhD^7*, Yan Yan, MS^2* and Paola Bianchi, BSc, PhD⁸

¹Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, Boston, MA
²Agios Pharmaceuticals, Inc., Cambridge, MA
³Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA
⁴Department of Transfusion Medicine and Cell Processing, Tokyo Women's Medical University, Tokyo, Japan
⁵Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom
⁶Department of Hematology, Van Creveldkliniek, University Medical Center Utrecht, Utrecht, Netherlands
⁷Josep Carerras ICO-Germans and University of Barcelona, Barcelona, Spain
⁸Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy

Julien Maquet^1,2*, Margaux Lafaurie, PharmD, PhD student^1,2,3*, Agnès Sommet, MD, PhD^1,2,3*, Maryse Lapeyre-Mestre, MD, PhD^1,2,3* and Guillaume Moulis^2,3,4*

¹Toulouse University Hospital, Toulouse, France
²Clinical Investigation Center 1436, Toulouse University Hospital, Toulouse, France
³UMR 1027 - Inserm - University of Toulouse, Toulouse, France
⁴Service de médecine interne, Toulouse University Hospital, Toulouse, France

Douglas Tremblay, MD¹, Joseph Rapp^2*, Naomi Alpert^2*, William Lieberman-Cribbin^2*, John Mascarenhas, MD¹, Emanuela Taioli, MD, PhD^2* and Saghi Ghaffari, MD, PhD¹

¹Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
²Institute for Translational Epidemiology, Icahn School of Medicine at Mount Sinai, New York, NY

Regis Peffault De Latour, MD, PhD^1*, Jeffrey Szer, MBBS², Austin G Kulasekararaj, MD, MBBS, MRCP, FRCPath³, Jin Seok Kim, MD, PhD^4*, Caroline I. Piatek, MD^5*, Alexander D. Kulagin, MD, PhD^6*, Anita Hill^7*, Jimmy Wang^7*, Ji Yu^8*, Masayo Ogawa, MD, FAAP^7*, Hubert Schrezenmeier⁹ and Jong Wook Lee, M.D., Ph.D.¹⁰

¹Hôpital Saint-Louis AP-HP, Paris, France
²Department of Clinical Haematology, Royal Melbourne Hospital, Melbourne, VIC, Australia
³King’s College Hospital, National Institute of Health Research/Wellcome King’s Clinical Research Facility, London, United Kingdom
⁴Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of (South)
⁵Jane Anne Nohl Division of Hematology, Keck School of Medicine of University of Southern California, Los Angeles, CA
⁶RM Gorbacheva Research Institute, Pavlov University, St. Petersburg, Russian Federation
⁷Alexion Pharmaceuticals, Inc., Boston, MA
⁸Alexion Pharmaceuticals Inc., Boston, MA
⁹Institute of Transfusion Medicine, University of Ulm, Ulm, Germany and Institute for Clinical Transfusion Medicine and Immunogenetics, German Red Cross Blood Transfusion Service Baden-Württemberg-Hessen/University Hospital Ulm, Ulm, Germany
¹⁰Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)

Antonio Risitano, MD, PhD^1,2, Alexander Röth, MD³, Austin G Kulasekararaj, MD, MBBS, MRCP, FRCPath⁴, Jeffrey Pu, MD, PhD^5*, Jun-ichi Nishimura, MD, PhD⁶, Lilyan Wright, PhD^7*, Anita Appius, PhD^8*, Alexandre Sostelly, PhD^8*, Sasha Sreckovic, MD⁸, Charlotte Vignal, PhD^8* and Talha Munir, MBBS^9*

¹Hematology, Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy
²Hematology and BMT Unit, AORN Moscati Avellino, Avellino, Italy
³Department of Hematology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
⁴Department of Haematological Medicine, King's College Hospital‐NHS Foundation Trust, NIHR Wellcome Foundation Clinical Research Facility, King's College London, London, United Kingdom
⁵Hollings Cancer Center of the Medical University of South Carolina, Charleston, SC
⁶Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
⁷Genentech, Inc, San Francisco, CA
⁸F. Hoffmann-La Roche Ltd, Basel, Switzerland
⁹St James University Hospital, Leeds, United Kingdom

Antonio Risitano, MD, PhD¹, Ilene C. Weitz², Carlos M. de Castro, MD³, Jean-Jacques Kiladjian⁴, Morag Griffin, MBChB, FRCPath^5*, Hisakazu Nishimori, MD, PhD^6*, Mohamed Hamdani^7*, Temitayo Ajayi^7*, Scott B. Baver, PhD^7* and Regis Peffault De Latour, MD, PhD^8*

¹Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, Italy
²Jane Anne Nohl Division of Hematology, Keck-USC School of Medicine, Los Angeles, CA
³Duke University School of Medicine, Durham, NC
⁴Centre d'Investigations Cliniques, Hôpital Saint-Louis; Assistance Publique – Hôpitaux de Paris; Université de Paris, Paris, France
⁵Department of Haematology, St James University Hospital, Leeds, United Kingdom
⁶Department of Hematology and Oncology, Okayama University Hospital, Okayama, Japan
⁷Apellis Pharmaceuticals, Inc., Waltham, MA
⁸French Reference Center for Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria, Assistance Publique – Hôpitaux de Paris, Université de Paris, Paris, France

Hervé Lobbes^1,2*, Matthieu Mahevas^3*, Sophie Alviset, MD^4*, Lionel Galicier, MD^5*, Nathalie Costedoat-Chalumeau, MD, PhD^6*, Zahir Amoura, MD, PhD^7*, Laurent Alric, MD, PhD^8*, Arnaud Hot, MD, PhD^9*, Stéphane Durupt, MD^10*, Marc Michel^3* and Bertrand Godeau^11*

¹Internal Medicine Department, Centre Hospitalier Universitaire de Clermont-Ferrand, Hôpital Estaing, Pierre-Bénite, France
²Internal Medicine Department, Lyon Sud University Hospital, Hospices civils de Lyon, Pierre-Bénite, France
³Department of Internal Medicine, National Referral Center for Adult Immune Cytopenias, Henri-Mondor University Hospital, Assistance Publique-Hôpitaux de Paris, UPEC, Créteil, France
⁴Equipe mobile d'Infectiologie, Hôpital Cochin, Assistance Publique Hôpitaux de Paris, Paris, France
⁵Department of Clinical Immunology, Saint-Louis University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France
⁶Department of Internal Medecine, Cochin University Hospital, Paris, FRA
⁷Service De Médecine Interne 2, Paris, FRA
⁸Service de médecine interne, hôpital Rangueil, Centre Hospitalier Universitaire de Toulouse, Toulouse, France
⁹Internal Medicine Department, Edouard Herriot University Hospital, Hospices Civils De Lyon, Lyon, France
¹⁰Internal Medicine Department, Lyon Sud University Hospital, Hospices Civils de Lyon, Pierre-Bénite, France
¹¹Service de Médecine Interne, Centre national de référence des cytopénies auto-immunes de l’adulte, Hôpital Henri Mondor, 51 avenue du Maréchal de Lattre de Tassigny, Assistance Publique Hôpitaux de Paris, Université Paris Est Créteil, 94000 Créteil, Créteil, France

Lindsey A Hildebrand, MD^*, Brett Dumas, MD, Charles Milrod, MD^* and James Hudspeth, MD^*

Boston Medical Center, Boston, MA

Satoshi Funakoshi, MD

Nagasaki Kidney Center, Nagasaki, NSK, Japan