Johnvesly Basappa, PhD^1*, Aaron Goldman, PhD^2*, Cosimo Lobello, PhD^3*, Shengchun Wang, PhD^1*, David Rushmore, BS^3*, Pin Lu, MD, Ph.D.^1*, Reza Nejati, MD³ and Mariusz Wasik, MD^1*

¹Fox Chase Cancer Center, Philadelphia, PA
²Wistar Institute, Philadelphia, PA
³Fox Chase Cancer Center, PHILADELPHIA, PA

James Nolan, MB, PhD¹, Daniel Angelov, MSc, MB¹, Darragh Nimmo, BSc^1*, Gráinne Holland, MSc^1*, Molly Davies, BSc^2*, Eugene Dillon, PhD^2*, David Reck, BA^1*, Craig Monger, PhD^1*, Chun-Wei David Chen, PhD³, Gerard L Brien, PhD^4,5*, Elisabeth Vandenberghe, MD, PhD^6*, Eric Conway, PhD^2* and Adrian Bracken, PhD^1*

¹Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland
²School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Dublin, Ireland
³Department of Systems Biology, Beckman Research Institute, City of Hope, Duarte, CA
⁴Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, United Kingdom
⁵MRC Human Genetics Unit, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, United Kingdom
⁶Department of Haematology, St James' Hospital, Dublin, Ireland

Yubao Wang, PhD^1*, Sanxiong Liu, PhD^2*, Hussein Ghamlouch, PhD^3*, Faith E Davies, MD² and Gareth Morgan, M.D., Ph.D.^2*

¹Perlmutter Cancer Center, Multiple Myeloma Research Program, NYU Grossman School of Medicine, NYU Langone Health, New York, NY
²Perlmutter Cancer Center, Multiple Myeloma Research Program, NYU Langone Health, New York, NY
³Hematology and Cell Therapy, CHU Amiens-Picardie, Amiens, France

Tommaso Gianferri^*, Teresa Mack^*, Daniel Tews, PhD^*, Klaus-Michael Debatin, MD, Professor, Lüder Hinrich Meyer, MD, Professor^* and Vera Münch, PhD^*

Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany

Sofia R Smith, BS^1,2* and George P Souroullas, PhD^1,3,4

¹Division of Oncology, Washington University in St. Louis, St. Louis, MO
²Department of Medicine, Washington University in St. Louis, Saint Louis, MO
³Department of Medicine, Washington University in St. Louis, St. Louis, MO
⁴Siteman Comprehensive Cancer Center, Washington University in St. Louis, St. Louis, MO

Kadriye Nehir Cosgun, PhD^1*, Mark E Robinson, PhD^1*, Nikol Agadzhanian, MSc^1*, Zhangliang Cheng, BSc^1*, Salim Oulghazi, MD^1*, Philipp Berning, MD^1*, David Fonseca-Arce^1*, Kohei Kume, PhD^1*, Jake Fontaine^1*, Lai N Chan, PhD¹, Jaewoong Lee, PhD^1,2*, Fang Yu, PhD^3*, Zhijian Qian⁴, Joo Y. Song, MD⁵, Wing Chung Chan, MD⁵, Jianjun Chen, PhD⁶, Mark M Taketo^7*, Hilde Schjerven, PhD^8* and Markus Müschen, MD¹

¹Center of Molecular and Cellular Oncology, Yale University, New Haven, CT
²School of Biosystems and Biomedical Sciences, Korea University, Seoul, Korea, Republic of (South)
³Division of Hematology/Oncology, Department of Medicine and Department of Biochemistry and Molecular Biology, The University of Florida, Gainesville, FL
⁴Division of Hematology/Oncology, Department of Medicine and Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL
⁵Department of Systems Biology, City of Hope Comprehensive Cancer Center, Duarte, CA
⁶City of Hope Comprehensive Cancer Center, Duarte, CA
⁷Graduate School of Medicine, Kyoto University, Kyoto, JPN
⁸Department of Laboratory Medicine and Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, CA

Vijay Negi, PhD^*, Ryan Bertoli, BS^*, Emily Muenzer^* and Peter D. Aplan, MD

Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD

Athanasia Liapodimitri^1,2*, Oscar Camacho^2*, Kayleigh Lunsford^2,3*, Ashley R Tetens^2,3*, Jordyn Craig-Schwartz^2,3*, Kegan Skalitzky^2,3*, Karen R Rabin, MD, PhD^4,5,6, Andy Feinberg, MD, MPH^2* and Michael Koldobskiy, MD, PhD^2,3*

¹Pediatric Oncology, Sidney Kimmel Comprehensive Cancer, Johns Hopkins University School of Medicine, BALTIMORE, MD
²Center for Epigenetics, Johns Hopkins University School of Medicine, Baltimore, MD
³Pediatric Oncology, Sidney Kimmel Comprehensive Cancer, Johns Hopkins University School of Medicine, Baltimore, MD
⁴Department of Pediatrics, Division of Pediatric Hematology/Oncology, Baylor College of Medicine, Houston, TX
⁵Department of Pediatrics, Baylor College of Medicine TX Children's Cancer Center, Houston, TX
⁶Cancer Center and Division of Pediatric Hematology/Oncology, Texas Children's Hospital, Houston, TX

Clarissa Corinaldesi^1*, Antony Holmes, PhD, BSc, MSc^1*, Elodie Bal, PhD^1*, Zeinab Amini-Farsani, PhD^1*, Govind Bhagat, MD², Laura Pasqualucci, MD¹, Katia Basso, PhD^1* and Riccardo Dalla-Favera, MD^1*

¹Institute for Cancer Genetics, Columbia University, New York, NY
²Department of Pathology & Cell Biology, Columbia University, New York, NY

Wenjuan Liao¹, Tian Liu^1*, Julian Grandvallet Contreras, BS^1*, Lynn Heltemes Harris, PhD^2*, Tzu Phang, PhD^1*, Michael A. Farrar, PhD², M. Eric Kohler, MD, Ph.D³, Terry J Fry, MD^4,5 and Patricia Ernst, PhD^1,6

¹Department of Pediatrics, Section of Hematology/Oncology/BMT, University of Colorado Anschutz Medical Campus, Aurora, CO
²Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN
³Department of Pediatrics-Hematology, Oncology, and BMT, University of Colorado Anschutz Medical Campus, Aurora, CO
⁴Department of Pediatrics- Hematology, Oncology, and Bone Marrow Transplant, University of Colorado Anschutz Medical Campus, Aurora, CO
⁵Immunology Department and HI3 Initiative, University of Colorado Anschutz Medical Campus, Aurora, CO
⁶Pharmacology Department, University to University of Colorado Anschutz Medical Campus, Aurora, CO

Eugenio Morelli, MD^1,2,3, Anil Aktas-Samur, PhD^3,4*, Domenico Maisano, PhD, MSc^3,4*, Claire Gao, BS^4*, Vanessa Favasuli, PhD^4*, Dimitrios Papaioannou, MD⁵, Na Liu, MS^4*, Marcello Turi, PhD^1*, Pietro Folino, M.Sc^6*, Laure Vreux, Ph.D.^7,8*, Michela Cumerlato, MS^4*, Liang Cheng, MS^7*, Iannis Aifantis, PhD⁹, Mariateresa Fulciniti, PhD⁴, Kenneth C. Anderson, MD¹⁰, Annamaria Gulla, MD¹, Mehmet K. Samur, PhD⁴ and Nikhil C. Munshi, MD⁴

¹Candiolo Cancer Institute FPO-IRCCS, Candiolo, Italy
²Department of Medical Oncology, University of Turin, Turin, Italy
³equally contributed, #, Italy
⁴Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA
⁵Perlmutter Cancer Center, Department of Medicine, Division of Hematology/Oncology, NYU Grossman School of Medicine, New York, NY, New York, NY
⁶Dana Farber Cancer Institute, Boston, MA
⁷Medical Oncology, Dana-Farber Cancer Institute, Boston
⁸Harvard Medical School, Boston
⁹Department of Pathology, NYU Grossman School of Medicine, New York, NY
¹⁰Dana Farber Cancer Institute, Harvard Medical School, Boston, MA

Karena Hsijan Lin^1*, Annie Wang^2*, Kailey Lashbrook^2*, Kaitlyn Chan^2*, Elizabeth Choe^3*, Ashwin Iyer^4*, Kelly R. Barnett, PhD^5*, Daniel Savic, PhD⁵, Russell J. H. Ryan, MD⁶ and Mark Chiang, MD, PhD³

¹Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI
²University of Michigan, Ann Arbor
³University of Michigan, Ann Arbor, MI
⁴Regeneron Pharmaceuticals, Tarrytown, NY
⁵St. Jude Children's Research Hospital, Memphis, TN
⁶Department of Pathology, University of Michigan Medical School, Ann Arbor, MI

Giulia Calabretto^1,2,3*, Elena Buson^3*, Zachary Hutchins^1*, Colleen Isabelle⁴, Sydnee Scozzafava^1*, Valentina Trimarco^2*, Barbara Mariotti^5*, Rachel Burzinski^1*, Amy Boles^1*, Elisa Rampazzo^2,3*, Antonella Teramo^2,3*, Sabrina Manni^2,3*, Monica Facco^2,3*, Gregorio Barilà^6*, Flavia Bazzoni^5*, Gianpietro Semenzato^3*, Livio Trentin², Jonathan E. Brammer⁷, Renato Zambello^2,3* and Anjali Mishra¹

¹Thomas Jefferson University, Sydney Kimmel Cancer Center, Philadelphia, PA
²Department of Medicine, Hematology and Clinical Immunology section, Padua University School of Medicine, Padova, Italy
³Veneto Institute of Molecular Medicine (VIMM), Padova, Italy
⁴Thomas Jefferson University, Philadelphia, PA
⁵Department of Medicine, Division of General Pathology, University of Verona, Verona, Italy
⁶Hematology Unit, Ospedale San Bortolo, Vicenza, Italy
⁷Division of Hematology, The Ohio State University, Columbus, OH

Srikanth Talluri, PhD^1,2*, Leutz Buon, MS^1*, Jiangning Zhao, MD, PhD^1*, Daniel Meglino, BS^1*, Chandraditya Chakraborty, PhD^1*, Chengcheng Liao, MD, PhD^1*, Mehmet K. Samur, PhD¹, David E. Root, PhD^3*, Masood A. Shammas, PhD^1,2* and Nikhil C. Munshi, MD^2,4

¹Dana Farber Cancer Institute, Harvard Medical School, Boston, MA
²VA Boston Healthcare System, Boston, MA
³Broad Institute of MIT and Harvard, Cambridge, MA
⁴Dana Farber Cancer Institute, The Jerome Lipper Myeloma Center, Boston, MA