Xiang Gao, MD^1*, Vegi M. Naidu, PhD^2*, Zhong Zhang^1*, Ines Sieber^1*, Vijay Pal Singh Rawat, PhD^3* and Michaela Feuring, MD^1*

¹Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany
²Institute For Experimental Cancer Research, Ulm, DEU
³Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, India

Aishwarya S Pawar¹, Aleena Alex^2*, Subin S George^2*, Charles Antony, PhD², Patrick Somers^2* and Vikram R Paralkar, MD²

¹Biomedical Graduate Studies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
²Department of Medicine, University of Pennsylvania, Philadelphia, PA

Tiankai Yin, BA, Michael H. Kramer, MD, PhD, Michael Bern, MD, PhD, Nichole Helton^*, Daniel George^*, Mieke Hoock^*, Sai Mukund Ramakrishnan, MS^*, Christopher A Miller, PhD^* and Timothy J Ley, MD

Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO

Ke Shang^1*, Guangshuai Teng^1*, Yuhui Zhang^1*, Yifan Duan^1*, Chenxiao Du^1*, Yan Wang^1*, Huiqin Zhang^1*, Xuelian Cheng^2*, Yuan Zhou^3*, Yajing Chu^3*, Weiping Yuan^1,3 and Jie Bai, MD⁴

¹Department of Hematology, the Second Hospital of Tianjin Medical University, Tianjin, China
²State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, CAMS & PUMC, Tianjin, China
³State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, National Clinical Research Center for Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
⁴Institute of Hematology &blood Disease Hospital, Tianjin City, Tianjin City, China

Josiah Murray, BS, MT^1,2,3, Lauren Banaag, BS^4*, Cary Stelloh^5*, Atrayee Ray, PhD^5*, Alison E Meyer, PhD⁶ and Sridhar Rao, MD, PhD^1,3,7,8

¹Hematopoiesis & Stem Cell Biology Program, Versiti Blood Research Institute, Milwaukee, WI
²Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, West Allis, WI
³Medical Scientist Training Program, Medical College of Wisconsin, Milwaukee, WI
⁴School of Pharmacy, Medical College of Wisconsin, Milwaukee
⁵Versiti Blood Research Institute, Milwaukee, WI
⁶Versiti Blood Research Institute, Brookfield, WI
⁷Department of Pediatrics, Division of Hematology, Oncology, and Bone Marrow Transplantation, Children's Hospital of Wisconsin, Milwaukee
⁸Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI

Josh R Faust, BSc^1,2*, Anilkumar Gopalakrishnapillai, PhD, MSc^1,3 and Sonali P Barwe, PhD, MSc^1,3

¹Nemours Children's Hospital, Wilmington, DE
²Department of Biological Sciences, University of Delaware, Wilmington, DE
³Department of Biological Sciences, University of Delaware, Newark, DE

Luca Guarnera, MD^1*, Adam Wahida^2*, Carmelo Gurnari, MD, PhD³, Stephan Hutter, PhD^4*, Sabine Stainczyk^5*, Nakisha D Williams, MBBS^1*, Arda Durmaz, PhD^6*, Yasuo Kubota, MD, PhD^1*, Carlos Bravo-Perez, MD^7*, Naomi Kawashima, MD PhD^8*, Simona Pagliuca, MD, PhD⁹, Yimin Huang^10*, Thomas Laframboise, PhD^11*, Valeria Visconte, PhD¹², Wencke Walter, PhD¹³, Manja Meggendorfer, PhD¹⁴, Claudia Haferlach, MD⁴, Wolfgang Kern, MD⁴, Frank Westermann^5*, Lars Feuerbach, PhD, MSc, BSc^15*, Torsten Haferlach, MD⁴ and Jaroslaw Maciejewski¹⁶

¹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
²Institute of Metabolism and Cell death, Neuherberg, Germany
³Cleveland Clinic Foundation, Cleveland, OH
⁴MLL Munich Leukemia Laboratory, Munich, Germany
⁵Hopp Children’s Cancer Center, Heidelberg, DEU
⁶Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, CLEVELAND, OH
⁷Department of Hematology and Medical Oncology, Hospital Universitario Morales Meseguer, University of Murcia, IMIB-Pascual Parrilla, CIBERER - Instituto de Salud Carlos III, Murcia, Spain
⁸Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
⁹Department of Hematology, Nancy University Hospital, Vandœuvre-lès-Nancy, France, France
¹⁰Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH
¹¹Case Western Reserve University, Cleveland, OH
¹²Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Taussig Cancer Institute, Cleveland, OH
¹³Munich Leukemia Laboratory, Munich, Germany
¹⁴MLL Munich Leukemia Laboratory, Munich, Bavaria, Germany
¹⁵Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, DEU
¹⁶Taussig Cancer Center, Cleveland, OH

Lin Han, PhD^1,2, Benjamin Braun^1,2*, Caroline A. Conway^1,2*, Amy Wang^1,2, Johann-Christoph Jann, MD^1,2*, Yihua Wang^1,2*, Kate I. Drachman^1,2*, Qingqing Yan, PhD^3*, Elodie Hatchi, PhD^1,2*, Phillip Wulfridge, PhD^3*, William Doyle^1,2*, Caroline N. Pitton^1,2*, Kavitha Sarma, PhD^3* and Zuzana Tothova, MD, PhD^1,2

¹Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
²Cancer Program, Broad Institute, Cambridge, MA
³Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA

Xueqin Xie, PhD^1*, Florisela Herrejon Chavez, PhD^2*, Ilyes Baali^3*, Eren L. Chu, PhD^4*, Chiara Evans^3*, Xuejing Yang, PhD^5*, Wei Wei, MD PhD^2*, Hanzhi Luo, PhD⁵, Sun Mi Park, PhD^6*, Kathryn Chang^5*, Aspen Pierson^5*, Grace Han^4*, Emily Batchelor^5*, Quaid D. Morris, PhD^7*, Ly Vu, PhD^8,9,10, Diu T.T. Nguyen, PhD^1,11 and Michael G. Kharas, PhD⁵

¹Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY
²Memorial Sloan Kettering Cancer Center, NY
³Weill Cornell Graduate School of Medical Sciences, NY
⁴Memorial Sloan Kettering Cancer Center, New York
⁵Molecular Pharmacology Program, Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York City, NY
⁶Memorial Sloan Kettering Cancer Center, ny
⁷Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York
⁸Memorial Sloan-Kettering Cancer Center, Vancouver, BC, Canada
⁹The University of British Columbia, Vancouver, BC, Canada
¹⁰Simon Fraser University, Vancouver, BC, Canada
¹¹Center for Hemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom

Ryan B. Day, MD, PhD, Sai Mukund Ramakrishnan, MS^*, Christopher A Miller, PhD^* and Timothy J Ley, MD

Department of Internal Medicine, Division of Oncology, Section of Stem Cell Biology, Washington University in St. Louis School of Medicine, Saint Louis, MO

Karina Hamamoto, PhD¹, Ganqian Zhu^2*, Julia Lesperance^1*, Huacheng Luo, PhD^1*, Ying D Li, PhD^2*, Nupur Nigam^3*, Arati Sharma, PhD, MSc^4*, Feng-Chun Yang, MD, PhD⁵, David F. Claxton, MD^6,7, Yi Qiu, PhD^7,8, Peter D. Aplan, MD⁹, Mingjiang Xu, MD, PhD² and Suming Huang, PhD^1,7

¹Division of Pediatric Hematology/Oncology, Pennsylvania State University College of Medicine, Hershey, PA
²Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX
³Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD
⁴Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA
⁵Department of Cell Systems and Anatomy, University of Texas Health Science Center, San Antonio, TX
⁶Division of Hematology/Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA
⁷Penn State Cancer Institute, Pennsylvania State University College of Medicine, Hershey, PA
⁸Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA
⁹Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD

Shiyu Xiao¹, Hongxia Chen, MD/PhD^1*, Michihiro Kobayashi, M.D, Ph.D.², Yunpeng Bai^3*, Sergio Barajas^1,2, Wenjie Cai^1,2, Zhong-Yin Zhang, PhD^3* and Yan Liu, PhD¹

¹Northwestern University, Chicago, IL
²Indiana University, Indianapolis, IN
³Purdue University, West Lafayette, IN

Rebecca Briggs^*, Hayley McMillan, BSc, PhD^*, Lydia E Roets, BSc, PhD^*, Kienan I Savage, Prof., PhD^* and Katrina M Lappin, PhD^*

Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, NI, United Kingdom

Dipanjali Saha, MSc^1*, Anne Angelillo-Scherrer² and Ramanjaneyulu Allam^3*

¹Department of BioMedical Research; Department of Hematology, University of Bern, Bern University Hospital (Inselspital Bern), Bern, AE, Switzerland
²Inselspital, Bern University Hospital, Bern, Switzerland
³Department of BioMedical Research, Department of Hematology, University of Bern, Bern University Hospital (Inselspital), Bern, Switzerland

Samantha A Swenson¹, Arjun Dhir, MSc¹, Isabelle S Weber^2*, Kasidy K Dobish^3*, Peng Xiao, PhD^4*, Shannon M. Buckley, PhD³ and Kate Hyde, PhD¹

¹Department of Biochemistry and Molecular Biology, and Fred and Pamela Buffet Cancer Center, University of Nebraska Medical Center, Omaha, NE
²University of Nebraska-Omaha, Omaha, NE
³University of Utah, SLC, UT
⁴Department of Genetics, Cell Biology, and Anatomy, and UNMC Bioinformatics and Systems Biology Core, University of Nebraska Medical Center, Omaha, NE

Matthew Markham, PhD^1*, Rebecca S Maynard, MSc^1*, George Bell^1*, Katherine Hampton, MSc, BSc^1*, Dominic James Fowler-Shorten, MRes, BSc^1*, Alyssa Nicole Polski-Delve, MSc, BSc^1*, Annalisa Altera, PhD^1*, Rosie Taylor^1*, Charlotte Hellmich, PhD, BSc, MBBChir^1,2, Kristian Bowles, MBBS, PhD^1,2 and Stuart A Rushworth, PhD³

¹Norwich Medical School, University of East Anglia, Norwich, United Kingdom
²Norfolk and Norwich University Hospital, Norwich, United Kingdom
³The University of East Anglia, Norwich, United Kingdom

Shiva Bamezai, PhD^1*, Jing He^1*, Pradeep Rajput, PhD^2*, Deniz Sahin, MSc^1*, Alex Jose Pulikkottil^1*, Fabian Mohr^1*, Mahalakshmi Naidu Vegi, PhD, MSc^1*, Rana Pratap Singh, PhD^3*, Deepshi Thakral, PhD^4*, Ritu Gupta, MD^4*, Christian Buske, MD¹ and Vijay Pal Singh Rawat, PhD^2*

¹Institute of Experimental Cancer Research, University Hospital of Ulm, Ulm, Germany, Ulm, Germany
²Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, India, New Delhi, India
³School of Life Sciences, Jawaharlal Nehru University, New Delhi, India, Delhi, India
⁴Laboratory Oncology, Dr. BRA. IRCH, All India Institute of Medical Sciences, New Delhi, India, New Delhi, India

Lilia Cabrera-Cosme^1*, Juan Rubio-Lara^1,2*, Ellie Bennett^1*, Joanna Milek^1*, Maria Jassinskaja^1*, Sandy MacDonald^3*, Karen Hogg^4*, Nicola K. Wilson^2*, Berthold Gottgens² and David Kent^1*

¹Centre for Blood Research, York Biomedical Research Institute, University of York, York, United Kingdom
²Department of Hematology, Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
³Data Science Hub, Technology Facility, University of York, York, United Kingdom
⁴Imaging and Cytometry Laboratory, Technology Facility, University of York, York, United Kingdom

Ayana Kon, MD, PhD^1,2,3, Masahiro M Nakagawa, MD, PhD¹, Azumi Tomita, BA^1*, Keisuke Kataoka, MD, PhD^4,5, Nobuyuki Kakiuchi, MD, PhD^1,6*, Manabu Nakayama, MD, PhD^7*, Haruhiko Koseki, MD, PhD^8*, Hideki Makishima, MD, PhD^1,9, Yasuhito Nannya, MD, PhD^1,10 and Seishi Ogawa, MD, PhD¹¹

¹Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
²The University of Tokyo, Tokyo, Japan
³Division of Stem Cell and Genome Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
⁴Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
⁵Division of Molecular Oncology, National Cancer Center Research Institute, Tokyo, Japan
⁶The Hakubi Center for Advanced Research, Kyoto University, Kyoto, Japan, Kyoto, Japan
⁷Chromosome Engineering Team, Department of Technology Development, Kazusa DNA Research Institute, Chiba, Japan
⁸Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
⁹Department of Hematology and Medical Oncology, Shinshu University, Matsumoto, Japan
¹⁰Institute of Medical Science Hospital, Department of Hematology-Oncology, The University of Tokyo, Tokyo, Japan
¹¹Kyoto University, Sakyoku, KYO, Japan

Giulia Biancon, PhD^1,2, Emma Busarello^3*, Matthew Cheng^1*, Simone Sidoli, PhD^4*, Jennifer VanOudenhove, PhD⁵, Giorgia Bucciarelli^3*, Toma Tebaldi, PhD^3* and Stephanie Halene, MD⁶

¹Yale University, New Haven, CT
²Policlinico Hospital of Milan, Milan, Italy
³University of Trento, Trento, Italy
⁴Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY
⁵Department of Internal Medicine, Section of Hematology, Yale University, New Haven, CT
⁶Yale Univ. School of Medicine, New Haven, CT

Moussa Diolombi^1*, Anish V Sharda, MBBS², Ming Chen, PhD^3*, Leinal Sejour^4*, Assaf Bester, PhD^5*, Daphna Nachmani, PhD^6*, John G. Clohessy, PhD^7*, Pier Paolo Pandolfi, MD PhD^8* and Lourdes M Mendez, MD, PhD^9*

¹University of Queensland, Brisbane, Australia
²Yale Comprehensive Cancer Center, Yale University School of Medicine, New Haven, CT
³Duke University School of Medicine, Durham, NC
⁴BIDMC, Boston, MA
⁵Technion, Haifa, Israel
⁶The Hebrew University of Jerusalem, Jerusalem, ISR
⁷Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
⁸Universita di Torino, Torino, Italy
⁹Section of Hematology, Department of Internal Medicine, Yale School of Medicine, New Haven, CT

Michael Rassner^1*, Tony Müller, PhD^2*, Kirstyn Anne Crossley^1*, Geoffroy Andrieux, PhD^3*, Lena Jakob^1*, Alina Müller-Rudorf^1*, Natalie Koehler^1*, Robert A. J. Oostendorp, PhD⁴, Gerhard Müller-Newen, PhD^5*, Katharina Schönberger^6*, Nina Cabezas-Wallscheid, PhD^6*, Irene Gonzalez-Menendez^7*, Leticia Quintanilla-Fend, MD⁷, Olaf Groß^8*, Oliver Gorka^8*, Marie Follo^1*, Anna Lena Illert^9*, Melanie Boerries, MD, PhD^10*, Robert Zeiser, MD¹ and Justus Duyster, MD^11*

¹Department of Medicine I, Medical Center–University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
²Department I of Internal Medicine, Center for Integrated Oncology, Aachen-Bonn-Cologne-Duesseldorf, University of Cologne, Cologne, Germany, Cologne, DEU
³Institute of Medical Bioinformatics, University Medical Center Freiburg, Freiburg, Germany
⁴Technical University Munich (Klinikum Rechts der Isar), Munchen, DEU
⁵Confocal Microscopy Facility, Interdisciplinary Center for Clinical Research IZKF, RWTH Aachen University, Aachen, Germany
⁶Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany
⁷Institute of Pathology and Neuropathology and Comprehensive Cancer Center Tübingen, Eberhard-Karls-University, Tübingen, Germany
⁸Institute of Neuropathology, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, Freiburg, Germany
⁹Department of Medicine III, Klinikum Rechts der Isar, Faculty of Medicine, Technical University of Munich, Munich, Germany
¹⁰Institute of Medical Bioinformatics and Systems Medicine, Medical Center – University of Freiburg, Faculty of Medicine, Freiburg, Germany
¹¹Department of Medicine I, Hematology, Oncology and Stem Cell Transplantation, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany