Gregory Crimmins, PhD^1*, Min Wu, PhD^2*, Francis Roushar, PhD^2*, Claudia F. Ramos Aguilar, BS^2*, Mehdi Gharghabi, PharmD^3*, Banumathi Cole, PhD^2*, Rosa Lapalombella, PhD³ and Dennise A. De Jesús-Díaz, PhD^2*

¹Remedy Plan Therapeutics, GAITHERSBURG, MD
²Remedy Plan Therapeutics, Gaithersburg, MD
³The Ohio State University, Columbus, OH

Bing Li, MD^1,2*, Qing-song Yin^3*, Xiaojing Yan, MD, PhD⁴, Min Hang^5*, Hai-Jun Guo^5*, Sheng Wang^5*, Yi-wei Wang^5*, Yong-jiang Hei^5* and Zhi-jian Xiao^1,2*

¹MDS and MPN Centre, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
²State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Tianjin, China
³Department of Hematology, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China
⁴Department of Hematology, The First Hospital of China Medical University, Liaoning, China
⁵Biocity Biopharmaceutics Co. Ltd, Wuxi, China

Donia M. Moujalled, PhD^1,2*, Giovanna Pomilio^1,2*, Thomas Morley^1,2*, Veronique Litalien^1,2*, Natasha S. Anstee, PhD^2,3*, Sun Loo, MBBS^2,3,4, Zhi-Han Yeoh, MBBS^1,2,4*, Clovis Boibessot, PhD^5*, Laura Bresson, PhD^5*, Ana-Leticia Maragno, PhD^5*, Caroline Liot, PharmD, PhD^5* and Andrew H Wei, MBBS, PhD, FRACP, FRCPA^3,6,7

¹The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
²Department of Medical Biology, The University of Melbourne, Melbourne, Australia
³The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia
⁴Department of Clinical Haematology, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, VIC, Australia
⁵Oncology Research and Development Unit, Institut de Recherches Servier, Gif-sur-Yvette, France
⁶Department of Clinical Haematology, Peter MacCallum Cancer Centre and The Royal Melbourne Hospital, Melbourne, VIC, Australia
⁷The University of Melbourne, Melbourne, VIC, Australia

Gowri Poigaialwar, PhD^1*, Sumiko Takao, MD, PhD^2,3, Sovira Chaudhry, MSc^4*, Laura K. Schmalbrock, MD^2,3*, Varun Gupta, PhD^1*, Alex Kentsis, MD, PhD^2,3,5,6, Julio A. Aguirre-Ghiso, PhD^7*, Marina Konopleva⁸, Maria S. Sosa, PhD^9* and Anna Skwarska, PhD⁴

¹Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, New York, NY
²Tow Center for Developmental Oncology, Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY
³Molecular Pharmacology Program, Sloan Kettering Institute, New York, NY
⁴Department of Oncology, Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, NY
⁵Departments of Pediatrics, Pharmacology and Physiology & Biophysics, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY
⁶Memorial Sloan-Kettering Cancer Center, New York, NY
⁷Department of Cell Biology, Cancer Dormancy Institute, Montefiore Einstein Comprehensive Cancer Center, Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine, New York, NY
⁸Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, NY
⁹Department of Microbiology and Immunology, Department of Oncology, Montefiore Einstein Comprehensive Cancer Center, Cancer Dormancy Institute, Albert Einstein College of Medicine, New York, NY

Yun Huang, MD, PhD^1*, Xuejie Jiang, M.D.^2* and Zhiquan Long^1*

¹Nanfang Hospital, Southern Medical University, Guangzhou, China
²Department of Hematology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China

Jyoti Kandarp^1*, Arnold Kloos^1*, Kerstin Goerlich^1*, Nadine Kattre^1*, Thomas Plenge^1* and Michael Heuser, MD^1,2

¹Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School (MHH), Hannover, Germany
²Department of Internal Medicine IV, University Hospital Halle (Saale), Halle (Saale), Germany

Gang Huang, PhD^1,2, Jie Bai^1*, Mingzhe Pan^1*, Dong Liu, PhD^3*, Min Xiong^3* and Shaojiang Deng, PhD^3*

¹Department of Cell Systems and Anatomy, UT Health San Antonio, San Antonio, TX
²Department of Pathology and Laboratory Medicine, UT Health San Antonio, San Antonio, TX
³Kind Pharmaceuticals, LLC, Redwood City, CA

Norman Lu^1*, Patricia Soulard^1*, Ibrahim Kay^1*, Kai Li^1*, Xiubin Gu^1*, Heather Sadlish^1*, Jay Lee^1*, Mariam Elhawary^1*, Michael Rotelli^1*, Sam Hasson^1*, Thomas Wynn^1*, Chris Yates^1*, Zhiping Weng^2*, Simon Xi^1* and Travis Wager, PhD^1*

¹Rgenta Therapeutics, Woburn, MA
²University of Massachusetts Medical School, Worcester, MA

Carmen Jimenez^1*, Sophie Peng^2*, Rama Krishna Narla^2*, Joshua Baughman^3*, Scott Wood^2*, Jean Lu^4*, Noelia Purroy^5*, Gina Yanochko^6*, Mark Nagy^7*, Gang Lu^4*, Mark Rolfe², Daniel W. Pierce^8* and Soraya Carrancio, PhD^2*

¹Bristol Myers Squibb, Seville, CA
²Research and Development, Bristol Myers Squibb, San Diego, CA
³Bristol-Myers Squibb, San Diego, CA
⁴GluBio Therapeutics, San Diego, CA
⁵Bristol Myers Squibb, San Francisco, CA
⁶Janssen Research & Development, San Francisco, CA
⁷Treeline Biosciences, Fairfax, VA
⁸Research and Development, Bristol Myers Squibb, Brisbane, CA

Nanni Schmitt^1*, Jana-Julia Siegler^2*, Alexandra Beck^1*, Lea Hoppe^1*, Mohammed Abba, MD^1*, Alexander Streuer, MD^1*, Stefan Klein, MD¹, Wolf-Karsten Hofmann, MD¹, Christian Merz^2*, Jens Pahl^2* and Daniel Nowak, MD^1*

¹Department of Hematology and Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
²Affimed GmbH, Mannheim, Germany

Orsola Di Martino, PhD^1,2, Mary Basse^1*, Nancy BJ Arthur, PhD³, Nishanth Gabriel, PhD^1*, Judith Sokei, BPharm, MSc¹, Ahmed Mahmoud, MD^3*, Marco Vitale, MD^4*, Elena Masselli, MD^2*, Cecilia Carubbi, PhD^2*, Stephen Sykes, PhD⁵ and Francesca Ferraro, MD, PhD⁶

¹Department of Pediatrics, Division of Hematology-Oncology, Washington University of Saint Louis, School of Medicine, Saint Louis
²Department of Medicine and Surgery, University of Parma, Parma, Italy
³Department of Internal Medicine, Division of Oncology, Washington University of Saint Louis, School of Medicine, Saint Louis
⁴Vita-Salute University IRCSS San Raffaele, Milano, ITA
⁵Department of Pediatrics, Washington University School of Medicine, St Louis, MO
⁶Department of Internal Medicine, Division of Oncology, Washington University of Saint Louis, School of Medicine, SAINT LOUIS, MO

Chan Yang^1*, Qinglong Guo^2*, Hui Hui^2*, Hui Li^2*, Chunhua Song, M.D., Ph.D.³ and Zheng Ge, MD, PhD¹

¹Department of Hematology, Zhongda Hospital, School of Medicine, Southeast University, Institute of Hematology Southeast University, Nanjing, China
²State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China
³The Ohio State University, Columbus, OH

Junichiro Yuda, MD, PhD¹, Takahiko Aramaki, PhD^2*, Haruka Matsumura^2*, Kanto Nakajima, PhD^2* and Motoya Mie, PhD^2*

¹Department of Hematology and Experimental Therapeutics, National Cancer Center Hospital East, Kashiwa-Shi, Chiba, Japan
²Kawasaki Research Laboratories, BrightPath Biotherapeutics Co.,Ltd., Kawasaki, Japan

Nathalie Javidi-Sharifi, MD, PhD¹, Jeremy Zhang^2*, Sandra Wiley, PhD, MSc³, Richard G Ghalie, MD, MBA³, Alexey V. Danilov, MD, PhD⁴ and Matthew S. Davids, MD, MMSc⁵

¹Dana-Farber Cancer Institute, Boston
²Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
³MEI Pharma, San Diego, CA
⁴City of Hope National Medical Center, La Canada Flintridge, CA
⁵Dana-Farber Cancer Institute, Boston, MA

Yohei Yasuda, MD^1*, Yuta Fukui, MD^2*, Ken Morita, MD, PhD^2*, Muzhapaer Mubalizi, PhD^3*, Hiroki Hayashida, MD, PhD^2*, Toshiya Hino^2*, Yosuke Masamoto, MD, PhD^3,4 and Mineo Kurokawa, MD, PhD^2,4

¹Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Bunkyo-Ku, TKY, Japan
²Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
³Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, JPN
⁴Department of Cell Therapy and Transplantation Medicine, The University of Tokyo Hospital, Tokyo, Japan

Masahiro Uni, MD, PhD^1,2, Asher Preska Steinberg, PhD^2,3*, Alicia Slavit^1,2*, Sophia Rha^1,2*, Shuyuan Cheng^1,2, Laura K. Schmalbrock, MD^1,2*, Jiayu Su^4,5,6*, Jing Ma, PhD^7*, Andrew McPherson, PhD^3*, Charles G. Mullighan, MBBS, MSc, MD⁷, Torsten Haferlach, MD⁸, Ilaria Iacobucci, PhD⁹, Jeffery M Klco, MD, PhD⁷, Raul Rabadan, PhD^4,5,10* and Alex Kentsis, MD, PhD^1,2,11

¹Molecular Pharmacology Program, Sloan Kettering Institute, New York, NY
²Tow Center for Developmental Oncology, Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY
³Halvorsen Center for Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY
⁴Program for Mathematical Genomics, Columbia University, New York, NY
⁵Department of Systems Biology, Columbia University, New York, NY
⁶New York Genome Center, New York, NY
⁷Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
⁸MLL Munich Leukemia Laboratory, Munich, Germany
⁹St. Jude Children's Research Hospital, Memphis, TN
¹⁰Department of Biomedical Informatics, Columbia University, New York, NY
¹¹Departments of Pediatrics, Pharmacology and Physiology & Biophysics, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY

Zhou Yu, PhD^1*, Zhiyan Liang, PhD^2*, Xinyi Yao, BS^1*, Yanqiu Ji, BS^1*, Dajun Yang, MD, PhD^1,2,3* and Yifan Zhai, MD, PhD^1,2,4

¹Ascentage Pharma (Suzhou) Co., Ltd., Suzhou, China
²Ascentage Pharma Group Inc., Rockville, MD
³Department of Experimental Research, State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China
⁴Guangzhou Healthquest Pharma Co., Ltd., Guangzhou, China

Josephine Dubois^1*, Kai Wu^2*, Darren King^3*, Xianing Zheng^1*, Qianyi Ma^1*, Karan Bedi^1*, Jun Li^1* and Sami N. Malek, MD⁴

¹University of Michigan, Ann Arbor
²UCSF, San Francisco
³Rogel Cancer Center, University of Michigan, Ann Arbor, MI
⁴Department of Medicine, University of Michigan Medical School, Ann Arbor, MI

Sophie C James^1*, Samantha Atkinson^2,3*, Richard Burt, PhD, FRCPath, MRCP^2,3,4*, Cristina Lo Celso^5* and Paolo Gallipoli, MD¹

¹Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom
²The Francis Crick Institute, London, United Kingdom
³Imperial College London, London, United Kingdom
⁴University College London Hospitals, London, United Kingdom
⁵Imperial College of London, London, United Kingdom

Changqing Jiao^1*, Chen Hu^2*, Mengya Pan^1*, Junjie Zhou^1*, Qingsong Liu^2* and Jian Ge^1*

¹Department of Hematology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
²Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, China

Xiaorong Gu, PhD^1*, Yahan Zhang, MS², Songa Bae^1*, Dongxu Jiang, PhD², Daniel Vail, PhD^2*, Simon Schlanger, MS^2*, Jaroslaw Maciejewski¹ and Babal K. Jha, PhD^1,2

¹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
²Center for Immunotherapy & Precision Immuno-Oncology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH

Bing Z. Carter, PhD¹, Po Yee Mak^1*, Baozhen Ke, BS^1*, Xiaogang Wu^2*, Steffen Boettcher, MD^3*, Lauren B. Ostermann, BSc^1*, Andrea Bedoy^1*, Georgina Gener-Ricos, MD^4*, Jayastu Senapati, MD, DM, MBBS⁴, Courtney D. DiNardo, MD, MSc⁵, Anna Puzio-Kuter^6*, Arnold Levine^7* and Michael Andreeff, MD, PhD¹

¹Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Zurich, Zurich, Switzerland
⁴Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX
⁶PMV Pharmaceuticals, Inc, Princeton, NJ
⁷Institute for Advanced Studies, Princeton

Sonali P Barwe, PhD, MSc¹, Neha Bhagwat, PhD² and Anilkumar Gopalakrishnapillai, PhD, MSc³

¹Nemours Children's Hospital, Wilmington, DE
²Prelude Therapeutics Incorporated, Wilmington, DE
³Lisa Dean Moseley Foundation Institute for Cancer and Blood Disorders, Nemours Children's Hospital, Wilmington, DE

Nataly Cruz-Rodriguez, PhD¹, Hua Tang, PhD^2*, Milad Rouhimoghadam, PhD^1*, Junzhuo Liao, PhD^2*, Benjamin Bateman^1*, Briana Bates, MS^1*, Mario Pinzas^1*, Xuhui Huang, PhD^2*, Weiping Tang, PhD^2* and Michael W. Deininger, MD, PhD^1,3

¹Versiti Blood Research Institute, Milwaukee, WI
²University of Wisconsin-Madison, Madison, WI
³Medical College of Wisconsin, Milwaukee, WI

Man Li^1,2*, Jingjie Dong^3*, Yaonan Hong^3*, Li Jin^2*, Chengtao Sun^2*, Qi Liu^3*, Liqin Li^2*, Xiaoxiao Han^2*, Shengqian Deng^2*, Yue Feng^2*, Yiping Shen^4*, Guoyin Kai^2* and Dijiong Wu, MD, PhD⁴

¹Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China
²Zhejiang Key TCM Laboratory for Chinese Resource Innovation and Transformation, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, China
³The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China
⁴Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China

Xiaorong Gu, PhD^1*, Songa Bae^1*, Yahan Zhang, MS², Nakisha D Williams, MBBS^1*, Dongxu Jiang, PhD², Simon Schlanger, MS^2*, Valeria Visconte, PhD³, Jaroslaw Maciejewski¹ and Babal K. Jha, PhD^1,2

¹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
²Center for Immunotherapy & Precision Immuno-Oncology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH
³Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Taussig Cancer Institute, Cleveland, OH

Sohani K Sandhu^1*, Julia G Kim^2*, Ritesh V Dontula^2*, Joshua J Cooper^2*, Jaden A Sherman^2*, Max P Rochette^2*, Lana E Kim^1*, Michele S. Redell, MD¹ and Alexandra McLean Stevens, MD³

¹Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX
²Baylor College of Medicine / Texas Children's Hospital, Houston, TX
³Baylor College of Medicine/ Texas Children's Hospital, Bellaire, TX

Luke Jones, PhD^1,2, Oleksii Rukhlenko, PhD^1,2*, Tânia Dias^1,2*, Ciardha Carmody^1,2,3*, Kieran Wynne^2*, Boris Kholodenko, PhD^1,2* and Jonathan Bond, MD, PhD^1,2,4*

¹School of Medicine, University College Dublin, Dublin, Ireland
²Systems Biology Ireland, Dublin, Ireland
³SFI Centre for Research Training in Genomics Data Science, Dublin, Ireland
⁴Children's Health Ireland at Crumlin, Dublin, Ireland

Daniel Neville^1*, Daniel Ferguson, PhD^1*, Emily Heikamp, MD, PhD², Charles Bell, PhD^3*, Scott A Armstrong, MD, PhD⁴ and Omer Gilan^5*

¹Monash University, Clayton, VIC, Australia
²Dana Farber Cancer institute, Boston, MA
³University of Queensland, Brisbane, Australia
⁴Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA
⁵Australian Centre for Blood Diseases, Monash University, Coburg, VIC, Australia