Adekunle Emmanuel Alagbe, MD, PhD¹, Lynda Little-Ihrig, BS^2*, Brian J Philips, PhD^3,4*, Stephanie M Mutchler, Ph.D^5*, Julia Z Xu, MD, MS⁶, Edwin K Jackson, Ph.D^7*, Stevan Tofovic, MD, Ph.D^7* and Enrico M Novelli, MD, MS²

¹Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, and Division of Classical Hematology, University of Pittsburgh, Pittsburgh, PA
²Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, and Division of Classical Hematology, University of Pittsburgh, Pittsburgh, PA
³Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, PA
⁴Vascular Medicine Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, PA
⁵Department of Medicine, Division of Renal-Electrolyte, University of Pittsburgh, Pittssburgh, PA
⁶Sickle Cell Branch, National Heart, Lung, and Blood Institute, NIH, Pittsburgh, PA
⁷Department of Pharmacology and Chemical Biology,, University of Pittsburgh, Pittsburgh, PA

Kenneth R Peterson, PhD¹, Matthew P Parker, PhD^2*, Aspin Denson, BS^2*, Will Brautman, BS^2*, Nick Lowe, BS^2*, Halyna Fedosyuk, MS^2*, Lesya V Novikova, PhD^2*, Jeffrey A Thompson, PhD^2*, Jennifer J Kohler, PhD^3* and Chad Slawson, PhD^1*

¹Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS
²University of Kansas Medical Center, Kansas City, KS
³University of Texas Southwestern Medical Center, Dallas, TX

Silvia Giannini, PhD¹, Earl Fields Jr., MPH^2*, Jesse Bueno^2*, Christopher Chambliss, PhD², Min Wu, MD, PhD¹ and David R Archer, PhD²

¹Disc Medicine, Watertown, MA
²Aflac Cancer and Blood Disorders Center, Emory University, Atlanta, GA

Reheman Adili, MD¹, Junmei Chen, PhD¹, Nicole Roads^1*, Richard Maldonado^1*, Hallie Lazaro^1*, Dominic W. Chung, Ph.D^1,2*, Xiaoyun Fu, PhD^1,2 and José A. López, M.D^1,2

¹Bloodworks Research Institute, Seattle, WA
²University of Washington, Seattle, WA

Keesha Roach, PhD, RN^1,2,3, Cole Collins, B.S.^4*, Erielle V. Culp, B.S.^1*, Ugochi Olivia Ogu, MD⁵ and Khyobeni Mozhui, PhD^6*

¹Department of Genetics, Genomics, and Informatics, University of Tennessee Health Science Center, Memphis, TN
²Department of Community and Population Health, University of Tennessee Health Science Center, Memphis, TN
³Center for Sickle Cell Disease, University of Tennessee Health Science Center, Memphis, TN
⁴College of Medicine, University of Tennessee Health Science Center, Memphis, TN
⁵Center for Sickle Cell Disease, University of Tennessee Health Sicence Center, Arlington, TN
⁶Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN

Ana Alves, BS^1*, Fuad Abdulla, MS^2*, Kaje Allen, BS^1*, Iryna A. Khasabova, PhD^3*, Sergey G. Khasabov, MD, PhD^3*, Mark Young, PhD^4*, Andrew Gomperts, MBA, JD^4*, Edward Gomperts, MD⁵, John D. Belcher, PhD², Gregory M. Vercellotti, MD² and Donald A. Simone, PhD^3*

¹School of Denistry, Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, MN
²Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN
³School of Dentistry, Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, MN
⁴Hillhurst Biopharmaceuticals, Inc, San Diego, CA
⁵Hillhurst Biopharmaceuticals, Inc, Montrose, CA

Jacopo Ceolan^1*, Petros Kolovos^2*, Enrica Federti^3*, Panagiotis Liakopoulos^4*, Veronica Riccardi^5*, Immacolata Andolfo, PhD^6*, Alessandro Mattè, BSc, PhD^7*, Roberta Russo^8*, Achille Iolascon, MD, PhD^9*, Helene Gleitz, PhD^10*, Sjaak Philipsen^11* and Lucia De Franceschi¹²

¹Azienda Ospedaliera Universitaria di Verona, Verona, Italy
²Department of Molecular Biology & Genetics,, Democritus University of Thrace, Alexandroupolis, GRC
³Department of Engineering for Innovation Medicine, University of Verona, Verona, Italy
⁴Department of Molecular Biology & Genetics, Democritus University of Thrace, Alexandroupolis, GRC
⁵Dept of Medicine,, University of Verona and Azienda Ospedaliera Universitaria Int, Verona, Italy
⁶Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy
⁷University of Verona 'G.B. Rossi' Hospital, Verona, Italy
⁸CEINGE - Biotecnologie Avanzate Franco Salvatore, CEINGE - Biotecnologie Avanzate, Napoli, NA, Italy
⁹University of Naples Federico II, CEINGE Biotecnologie Avanzate, Naples, Italy
¹⁰Department of Developmental Biology, Erasmus Medical Center, Rotterdam, NLD
¹¹Erasmus University Medical Center, Rotterdam, NLD
¹²University of Verona, Verona, Italy

Victor Gabriel de Faria Pastre, BSc^1*, Aline Renata Pavan, PhD^2*, Carolina Lanaro, BSc, PhD^2*, Dulcineia Albuquerque, PhD^2*, Rafael Consolin Chelucci, PhD^3*, Leonardo Luiz Gomes Ferreira, PhD^3*, Adriano D. Andricopulo, PhD^3*, Jean Leandro Dos Santos, PhD^4* and Fernando Ferreira Costa, MD, PhD⁵

¹Hematology and Hemotherapy Center, University of Campinas - UNICAMP, Campinas, SP, Brazil
²Hematology and Hemotherapy Center, University of Campinas - UNICAMP, Campinas, Brazil
³Physics Institute of Sao Carlos, University of Sao Paulo, Sao Carlos, Brazil
⁴School of Pharmaceutical Sciences, Sao Paulo State University, Araraquara, Brazil
⁵Hematology and Hemotherapy Center, University of Campinas, Campinas, Brazil

Carolina Mireles, BS^1*, Hemanth M Cherukury, PhD^1,2, Yugal Goel^3*, Kendall O'Daniel, BS^1*, Mya Arellano, BS^1*, Donovan Alexander Argueta, PhD¹ and Kalpna Gupta, PhD^1,2,4

¹Hematology/Oncology Division, Department of Medicine, University of California, Irvine, Irvine, CA
²Department of Pharmaceutical Sciences, University of California, Irvine, Irvine
³Hematology/Oncology Division, Department of Medicine, University of California, Irvine, Orange, CA
⁴Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN

Thiago Trovati Maciel, PhD^1*, Nabiha Sbeih, MD^1*, Rachel Rignault-Bricard^1*, Isabelle Chevalme^1*, Slimane Allali^1,2*, Camille Brochier, PhD^3*, Anna Kiialainen^4*, Tovo David⁴ and Olivier Hermine, MD, PhD^1,5

¹Institut Imagine - INSERM U1163, Paris, France
²Sickle Cell Center, Pediatrics Department, Necker Hospital for Sick Children, APHP, Paris Cité University, Paris, FRA
³Institut Roche, Boulogne Billancourt, France
⁴F. Hoffmann-La Roche Ltd, Basel, Switzerland
⁵Hematology, Necker Hospital, Greater Paris University Hospitals (AP-HP), Paris, France

Yugal Goel^1*, Sirsendu Jana, PhD^2*, Mya Arellano, BS^3*, Reina A Lomeli^3*, Graham J Velasco, MSHCA^4*, Donovan A Argueta, PhD³, Richard Prince, PhD^5*, Abdu I Alayash, PhD^2*, Joel Friedman, PhD^5,6* and Kalpna Gupta, PhD^3,7

¹Hematology/Oncology Division, Department of Medicine, University of California, Irvine, Orange, CA
²Laboratory of Biochemistry and Vascular Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD
³Hematology/Oncology Division, Department of Medicine, University of California, Irvine, Irvine, CA
⁴Pathology Department, VA Long Beach Healthcare System, Long Beach, CA
⁵Vascarta Inc, Summit, NJ
⁶Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY
⁷Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN

Laila Elsherif, PhD¹, Yanxin Chen, BS^2*, Kammie L. Patillo, RN^3*, Paula McCune, RN^3*, Qingning Zhou, PhD^4* and Kenneth I. Ataga, MD¹

¹Center for Sickle Cell Disease, The University of Tennessee Health Science Center, Memphis, TN
²College of Medicine, The University of Tennessee Health Science Center, Memphis, TN
³Office of Clinical Trials, The University of Tennessee Health Science Center, Memphis, TN
⁴Department of Mathematics and Statistics, The University of North Carolina at Charlotte, Charlotte, NC

Alicia Matthews, BS^1*, Christopher Hu, BS^1*, Zoe Sekyonda, BS^2*, Umut Gurkan, PhD³ and Yolanda Fortenberry, Ph.D.¹

¹Biology Department, Case Western Reserve University, Cleveland, OH
²Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH
³Case Western Reserve University, Cleveland, OH

Christina Lisk, PhD^1*, Francesca I Cendali, BS², Delany Swindle^1*, Gemlyn George, MD^1*, Kathryn Louise Hassell, MD¹, Rachelle Nuss, MD^3*, Angelo D'Alessandro, PhD⁴, Paul Buehler, PharmD, PhD^5* and David Irwin, Ph.D^1*

¹University of Colorado Anschutz Medical Campus, Aurora, CO
²University of Colorado School of Medicine, Anschutz, Aurora, CO
³Center for Cancer and Blood Disorders, University of Colorado Anschutz Medical Campus, Aurora, CO
⁴Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO
⁵Center for Blood Oxygen Transport and Hemostasis, University of Maryland, Baltimore, MD

Jennell U. White, PhD^1,2, Xiufeng Gao, MD^3*, Kerry Bellemare^4*, Gershwin Theophilus Blyden, MD, PhD^5*, Lanetta Bronté-Hall, MD, MPH, MSPH⁶, Alexander K Glaros, MD^7*, Andrew D. Campbell, MD⁸, Olufunke Y. Martin, MD⁹, Sharon Pennington, MD¹⁰, Ofelia A. Alvarez, MD¹¹, Indryas L. Woldie, MD^12,13, Nnamdi Okeke, PharmD^14* and Patrick C. Hines, MD, PhD^1,15

¹Functional Fluidics Inc, Detroit, MI
²Department of Pharmacology/Pediatrics, Wayne State University, Grosse Pointe Woods, MI
³Functional Fluidics, Detroit, MI
⁴Pharmacology, Wayne State University School of Medicine, Detroit
⁵Foundation for Sickle Cell Disease Research, Miami, FL
⁶The Foundation for Sickle Cell Disease Research, Hollywood, FL
⁷Central Michigan University College of Medicine, Mount Pleasant, MI
⁸Center for Cancer and Blood Disorders, Children's National Medical Center, Washington, DC
⁹Center for Cancer and Blood Disorders, Children's Medical Center Dallas, Dallas, TX
¹⁰Mississippi Center For Advanced Medicine, Madison, MS
¹¹Department of Pediatrics, Division of Pediatric Hematology/Oncology, Univ. of Miami School of Med., Miami, FL
¹²Wayne State University, Detroit
¹³Karmanos, Detroit, MI
¹⁴Functional Fluidics, Detroit
¹⁵Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI

Joel Dzidzorvi Kwame Disu, BSc, MSc^1*, Lara Abdelmohsen^1,2*, Nahom Mossazghi, BS, MS^1*, Elizabeth Meinert-Spyker^1*, Christine Saber, MD^3,4,5*, Julia Xu, MD, PhD, MS^4,5,6,7 and Sossena Wood, PhD, BSc^1,8*

¹Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA
²Carnegie Mellon University, Pittsburgh
³Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, PA
⁴Vascular Medicine Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, PA
⁵Division of Classical Hematology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA
⁶University of Pittsburgh, Pittsburgh, PA
⁷Sickle Cell Branch, National Heart, Lung, and Blood Institute, NIH, Pittsburgh, PA
⁸Carnegie Mellon University, Pittsburgh, PA