Bill Wambaka, MBChB, MS^1*, Amiirah Mpungu, MBChB^1*, Vincent Mboizi, MD, MMED, MS^1*, Dennis Kalibala, MSc^1*, Grace Nambatya, RN^1*, Susan Murungi, RN^1*, Maxencia Kabatabaazi, MMed^1*, Phillip Kasirye, MD^2*, Deogratias Munube, MD^2*, Robert Opoka, MBChB, PhD^3*, Richard Idro, MBChB, PhD^2* and Nancy S. S. Green, MD⁴

¹Global Health Uganda, Kampala, Uganda
²Department of Pediatrics and Child Health, Makerere University College of Health Sciences, Kampala, Uganda
³Aga Khan University Medical School, Nairobi, Kenya
⁴Division of Pediatric Hematology, Oncology and Stem Cell Transplantation, Columbia University Irving Medical Center, New York, NY

Suruchi Salgar, BS^1*, Abi-Grace Savizon^2*, Ankona Banerjee, MSc^3*, Duc T. Nguyen, MD, PhD^4*, Gladstone Airewele, MD^5,6, Mary Reeni George, PhD, ABPP^2* and Venee Tubman, MD^7,8

¹Baylor College of Medicine, Houston, TX
²Texas Children's Hospital, Houston
³Baylor College of Medicine, Houston
⁴Department of Pediatrics, Baylor College of Medicine, Houston, TX
⁵Department of Pediatrics, Division of Hematology/Oncology, Baylor College of Medicine, Houston, TX
⁶Texas Children's Cancer and Hematology Center, Houston, TX
⁷Texas Children's Hospital, Houston, TX
⁸Texas Children's Hospital, Cancer and Hematology Centers, Houston, TX

Lara Abdelmohsen^1*, Nahom Mossazghi, BS, MS^1*, Shidhartho Roy, MS, BSc^1*, Joel Dzidzorvi Kwame Disu, BSc, MSc^1*, Elizabeth Meinert-Spyker^1*, Christine Saber, MD^2*, Julia Xu, MD, PhD, MS² and Sossena Wood, PhD, BSc^1*

¹Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA
²Division of Classical Hematology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA

Sara Soliman, MD¹, Neeha Dambala, BS^2*, Preethi Kannan^2* and Modupe Idowu, MD¹

¹Department of Hematology and Oncology, The University of Texas Health Science Center McGovern Medical School, Houston, TX
²The University of Texas Health Science Center McGovern Medical School, Houston, TX

Apeksha Sridhar, MSc^1*, Eric Ichesco, BS^2*, Andrew Q Pucka, BS^3*, Andrew RW O'Brien, MD⁴, Steven E Harte, PhD^2*, Richard E Harris, PhD^1,5* and Ying Wang, MD, PhD^3,4

¹School of Medicine, Susan Samueli Integrative Health Institute, University of California, Irvine, Irvine, CA
²Department of Anesthesiology, Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, MI
³Department of Anesthesia, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN
⁴Division of Hematology/Oncology, Indiana University School of Medicine, Indianapolis, IN
⁵Department of Anesthesiology and Perioperative Care, University of California at Irvine, Irvine, CA

Eboni I. Lance, MD, PhD^1,2, Aliyah Allick, BS, MHS^2*, Alicia Cannon, PhD^3*, Lakeya S. McGill, PhD^4,5*, Wingel Xue, BS^6,7*, Lauren Anthony, BA^7,8*, Jessica Liang, BS^7,9*, Phil Fanara, MA^2*, Lydia H. Pecker, MD, MS^7,10, C. Patrick Carroll, MD^11* and Sophie Lanzkron, MD^7,12

¹Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD
²Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, MD
³Department of Neuropsychology, Kennedy Krieger Institute, Baltimore, MD
⁴Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA
⁵Division of Rehabilitation Psychology and Neuropsychology, Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD
⁶Harvard Medical School, Boston, MA
⁷Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD
⁸College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK
⁹UC San Francisco, San Francisco, CA
¹⁰Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD
¹¹Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD
¹²Thomas Jefferson University, Philadelphia, PA

Olivier Pouliot, MD^1*, Gregory Jacquin, MD^2,3,4*, George Nilton Nunes Mendes, MD^2*, Chrystelle Charles, MD^1*, Costa Kazadi, MD, MSc^4*, Jonathan St-Onge, MD^1*, Sara-Maude Desforges, MD¹, Olena Bereznyakova, MD^2,3,4*, Christian Stapf, MD^2,3,4* and Stephanie Forte, MD, MSc^1,4,5

¹Faculty of Medicine, University of Montreal, Montreal, QC, Canada
²Division of Neurology, CHUM, Montreal, QC, Canada
³Department of Neurosciences, University of Montreal, Montreal, QC, Canada
⁴CRCHUM, Montreal, QC, Canada
⁵Department of Medicine, CHUM, Montreal, QC, Canada

Elexis Price^1*, Heath Aston^2*, Emma Hazenberg, BSc^3*, Girindra Raval, MBBS⁴, Siera Gollan, PhD^4*, Elena Wernecke^5*, Faizan Boghani^5*, Casey Gazza, BS^5*, Asim Ahmed^5*, Neha Balachandran^6*, Daniel Herrera^5*, Satya Jella^5*, Ahmed Shetewi^5*, Hongyan Xu, PhD^7* and Abdullah Kutlar, MD⁸

¹Medical College of Georgia at Augusta University, Augusta, GA
²Medical College of Georgia, Marietta, GA
³Medical College of Georgia, Roswell, GA
⁴Center for Blood Disorders, Medical College of Georgia, Augusta, GA
⁵Medical College of Georgia, Augusta, GA
⁶Medical College of Georgia, Suwanee, GA
⁷Department of Population Health Sciences, Augusta University, Augusta, GA
⁸Department of Medicine, Sickle Cell Center, Augusta University, Augusta, GA

Rowan Brothers, BS^1*, Michael Arrington, BS^1*, Kristin Wubbena, BS^1*, Ayesha Quadri, BS^1*, Mariam Akbar, BS^1*, Katherine Turrentine, BS^1*, Eswar Damaraju, MS^2*, Richard Jones, PhD^2*, Jack Knight-Scott, PhD^2*, Bryan Philbrook, MD^3,4*, Clark Brown, MD, PhD^4,5, Beatrice E Gee, MD^4,5, Kirshma Khemani, MD^4,5*, Seung Yup Lee, PhD^6*, Adam Goldman-Yassen, MD^2* and Erin Buckley, PhD^1,7*

¹Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA
²Department of Radiology, Children's Healthcare of Atlanta, Atlanta, GA
³Department of Neurology, Children's Hospital of Atlanta, Atlanta, GA
⁴Department of Pediatrics, Children's Healthcare of Atlanta and Emory University, Atlanta, GA
⁵Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA
⁶Department of Electrical and Computer Engineering, Kennesaw State University, Marietta, GA
⁷Department of Pediatrics, Emory University, Atlanta, GA

Rima Zahr, DO^1*, Shuyan Chen, PhD^2*, Parul Rai, MD, MBBS³, Jane S Hankins, MD, MS³, Winfred C. Wang, MD⁴, Jeffrey D Lebensburger, DO⁵, Guolian Kang, PhD² and Kenneth I. Ataga, MD¹

¹University of Tennessee Health Science Center, Memphis, TN
²Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN
³St. Jude Children's Research Hospital, Memphis, TN
⁴Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN
⁵University of Alabama at Birmingham, Birmingham, AL

Tro Sekayan, MD¹, Pranav S Garimella, MD, MPH^2*, Jhaqueline Valle, MPH^3* and Srila Gopal, MD¹

¹Department of Medicine, Division of Hematology/Oncology, University of California San Diego, San Diego, CA
²Division of Nephrology and Hypertension, University of California San Diego, San Diego, CA
³Tracking California, Public Health Institute, Oakland, CA

Emily Limerick, MD

Cellular and Molecular Therapeutics Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD

Patrick Van Dreden, PhD¹, Aurelie Rousseau, PhD^2*, Matthieu Grusse^2* and Grigoris Gerotziafas^3*

¹Stago, Gennevilliers, France
²Department of Clinical Research, Diagnostica Stago,, Gennevilliers, France
³Sorbonne Université, INSERM UMRS-938, Team "Cancer Vessels, Biology and Therapeutics", Group "Cancer - Angiogenesis - Thrombosis," Institut Universitaire de Cancérologie, Centre de Recherche Saint Antoine, Hôpital Saint Antoine, Assistance Publique - Hôpi, Paris, France

Thomas D'Humieres, MD^1,2*, Mathilde Stevenard^3*, Haytham Derbel, MD, PhD^4*, Sihem Iles, MD^5*, Gonzalo De Luna, MD^6,7*, Vania Tacher, MD, PhD^8*, Ziana Amorouayeche, MD^9*, Anne-Laure Pham Hung D'Alexandry D'Orengiani, PhD^10*, Yosr Zaouali^11*, Anoosha Habibi, MD^12,13,14, Laurent Boyer, MD, PhD^15*, Lara Alassaad, MD^16*, Henri Guillet, MD^17*, Laurent Savale, MD, PhD^18*, Geneviève Derumeaux, MD, PhD^19* and Pablo Bartolucci, MD, PhD^20,21,22*

¹CHU Henri Mondor. UPEC. AP-HP, CréTeil, France
²Paris Cardiovascular Research Center - PARCC, Inserm team 8, Paris, France
³Henri Mondor teaching hospital, Physiology department, APHP, Créteil, France
⁴Radiology Department, Henri Mondor Hospital, Assistance Publique HôPitaux, CréTeil, FRA
⁵CHU Henri Mondor - AP-HP - FHU SENEC, CréTeil, FRA
⁶APHP, Paris, France
⁷Sickle Cell Referral Center, Department of Internal Medicine, Henri-Mondor University Hospital- UPEC, AP-HP, Creteil, France
⁸Radiology department, CHU Henri Mondor, APHP, Créteil, France
⁹Physiology Department, CHU Henri Mondor, CréTeil, FRA
¹⁰University Paris-Est-Créteil, IMRB, Inserm U955, Laboratory of excellence LABEX, Henri Mondor University Hospitals, APHP, Sickle Cell Referral Center-UMGGR, Créteil, FRA
¹¹Sickle Cell Referral Center - CHU Henri Mondor, Créteil, France
¹²Sickle Cell Referral Center, Department of Internal Medicine, Henri-Mondor University Hospital, APHP, Creteil Cedex, France
¹³1 avenue Claude Vellefaux, ERN-EuroBloodNet, PARIS, France
¹⁴Sickle Cell Referral Center, Sickle Cell Referral Center, Department of Internal Medicine, Henri-Mondor University Hospital- UPEC, AP-HP, Creteil, France
¹⁵Institut Mondor de Recherche Biomédicale, équipe 08,, Université Paris Est Créteil (UPEC), Creteil, France
¹⁶Physiology department, CHU Henri Mondor, APHP, CréTeil, FRA
¹⁷Internal medicine department - CHU Henri Mondor - APHP, Créteil, France
¹⁸Kremblin Bicêtre teaching hospital, Le Kremlin Bicêtre, FRA
¹⁹CHU Henri Mondor, FHU SENEC, Créteil, France
²⁰University Paris-Est-Créteil, IMRB, Inserm U955,, Henri Mondor University Hospitals, APHP, Sickle Cell Referral Center-UMGGR, Creteil, France
²¹UMGGR French Red Blood Cell Coordinating Referral Center, APHP UPEC IMRB, Créteil, France
²²Université Paris-Est Créteil, INSERM U955, IMRB, Laboratory of excellence LABEX GRex, Créteil, France

Thomas D'Humieres, MD^1,2*, Théo Simon, MD^3*, Kristoffer Grundtvig Skaarup, MD^4*, Laurent Savale, MD, PhD^5*, Paul Breillat, MD^6*, Jocelyn Inamo, MD, PhD^7*, Gylna Loko, MD^8*, Christelle Chantalat-Auger, MD^9*, Anne-Laure Pham Hung D'Alexandry D'Orengiani, PhD^10*, Anoosha Habibi, MD^11,12,13, Gonzalo De Luna, MD^14,15*, Niklas Dyrby Johansen, MD^4*, François Lionnet, MD, PhD^16*, Frederic Galacteros, Prof, MD^17*, Etienne Audureau, MD, PhD^18*, Mark T. Gladwin, MD^19*, Tor Biering-Sørensen, MD, PhD^20*, Geneviève Derumeaux, MD, PhD^21* and Pablo Bartolucci, MD, PhD^22,23,24,25*

¹Physiology Department, FHU SENEC, INSERM IMRB U955, Henri-Mondor University Hospital- UPEC, AP-HP, Créteil, France
²Paris Cardiovascular Research Center - PARCC, Inserm team 8, Paris, France
³Henri Mondor teaching hospital, Physiology department, APHP, Créteil, France
⁴Department of Cardiology | Center for Translational Cardiology and Pragmatic Randomized Trials (CTCPR) & Cardiovascular Non-Invasive Imaging Research Laboratory (CIRL), Hellerup, Denmark
⁵Kremblin Bicêtre teaching hospital, Le Kremlin Bicêtre, FRA
⁶Paris Cardiovascular Research Center - PARCC, Inserm team 8, Université Paris Cité, Paris, France., Paris, France
⁷Department of Cardiology, University of the French West Indies and Guiana, Fort-de-France, Martinique, France., Fort-de-France, France
⁸CHU Martinique, Le Lamentin, Martinique
⁹Department of Internal Medicine, Bicetre Teaching Hospital, AP-HP, Universite Pa, Le Kremlin Bicetre, France
¹⁰University Paris-Est-Créteil, IMRB, Inserm U955, Laboratory of excellence LABEX, Henri Mondor University Hospitals, APHP, Sickle Cell Referral Center-UMGGR, Créteil, FRA
¹¹Sickle Cell Referral Center, Department of Internal Medicine, Henri-Mondor University Hospital, APHP, Creteil Cedex, France
¹²1 avenue Claude Vellefaux, ERN-EuroBloodNet, PARIS, France
¹³Sickle Cell Referral Center, Sickle Cell Referral Center, Department of Internal Medicine, Henri-Mondor University Hospital- UPEC, AP-HP, Creteil, France
¹⁴APHP, Paris, France
¹⁵Sickle Cell Referral Center, Department of Internal Medicine, Henri-Mondor University Hospital- UPEC, AP-HP, Creteil, France
¹⁶HôPital Tenon, Paris, FRA
¹⁷GHU Henri Mondor, AP-HP, Creteil, France
¹⁸Unité de Recherche Clinique, Henri-Mondor University Hospital- UPEC, AP-HP, Creteil, France
¹⁹Department of Medicine, University of Maryland School of Medicine, Baltimore, MD
²⁰Department of Cardiology | Center for Translational Cardiology and Pragmatic Randomized Trials (CTCPR) & Cardiovascular Non-Invasive Imaging Research Laboratory (CIRL), Hellerup, DNK
²¹CHU Henri Mondor, FHU SENEC, Créteil, France
²²Université Paris-Est Créteil, INSERM, IMRB, Laboratory of excellence LABEX GRex, Créteil, France
²³University Paris-Est-Créteil, IMRB, Inserm U955,, Henri Mondor University Hospitals, APHP, Sickle Cell Referral Center-UMGGR, Creteil, France
²⁴UMGGR French Red Blood Cell Coordinating Referral Center, APHP UPEC IMRB, Créteil, France
²⁵Université Paris-Est Créteil, INSERM U955, IMRB, Laboratory of excellence LABEX GRex, Créteil, France

Sihem Iles, MD^1*, Alice Mero, MSc^2*, Pablo Bartolucci, MD, PhD^3,4,5,6*, Anoosha Habibi, MD^7,8,9, Gonzalo De Luna, MD^10*, Geneviève Derumeaux, MD, PhD^11*, Costin Radu, MD, PhD^12*, Eric Bergoend, MD^12*, Thierry Folliguet, Pr^12*, Antonio Fiore, MD^12* and Thomas D'Humieres, MD^2,13*

¹CHU Henri Mondor - AP-HP - FHU SENEC, CréTeil, FRA
²Paris Cardiovascular Research Center - PARCC, Inserm team 8, Paris, France
³Université Paris-Est Créteil, INSERM, IMRB, Laboratory of excellence LABEX GRex, Créteil, France
⁴Hematology Department, Sickle Cell Referral Center, Department of Internal Medicine, Henri-Mondor University Hospital- UPEC, AP-HP, Créteil, France
⁵University Paris-Est-Créteil, IMRB, Inserm U955,, Henri Mondor University Hospitals, APHP, Sickle Cell Referral Center-UMGGR, Creteil, France
⁶Université Paris-Est Créteil, INSERM U955, IMRB, Laboratory of excellence LABEX GRex, Créteil, France
⁷Sickle Cell Referral Center, Department of Internal Medicine, Henri-Mondor University Hospital, APHP, Creteil Cedex, France
⁸1 avenue Claude Vellefaux, ERN-EuroBloodNet, PARIS, France
⁹Sickle Cell Referral Center, Sickle Cell Referral Center, Department of Internal Medicine, Henri-Mondor University Hospital- UPEC, AP-HP, Creteil, France
¹⁰APHP, Paris, France
¹¹CHU Henri Mondor, FHU SENEC, Créteil, France
¹²Cardiac surgery department, Henri Mondor hospital - APHP, Créteil, France
¹³CHU Henri Mondor. UPEC. AP-HP, CréTeil, France

Samantha N. Atkinson, PhD^1*, Katelyn E. Sadler, PhD^2*, Janelle Highland, MA^3*, Nicole Steiner^3*, Jessica J. Rico^1*, Dawn Retherford^1*, Jane S Hankins, MD, MS⁴, Hamda Khan^4*, Michelle Brignac^4*, Joshua Field, MD⁵, Ashima Singh, PhD, MS⁶, Nita Salzman, MD, PhD^7* and Amanda M. Brandow, DO, MS⁸

¹Medical College of Wisconsin, Milwaukee, WI
²University of Texas at Dallas, Richardson, TX
³Department of Pediatrics, Section of Hematology/Oncology/Bone Marrow Transplantation, Medical College of Wisconsin, Milwaukee, WI
⁴St. Jude Children's Research Hospital, Memphis, TN
⁵Division of Hematology/Oncology, Medical College of Wisconsin, Milwaukee, WI
⁶Department of Pediatrics, Section of Hematology/Oncology/Bone Marrow Transplantation, Medical College of Wisconsin, Pewaukee, WI
⁷Medical College of Wisconsin, Children's Research Institute, Milwaukee
⁸Department of Pediatrics, Section of Hematology/Oncology/Bone Marrow Transplantation, Medical College of Wisconsin and Children’s Research Institute of Children’s Wisconsin, Milwaukee, WI

Karecia Byfield, MBBS^1*, Colton Frisco Jones^2*, Elvis Obomanu, MBBS^1*, Arshi Syal, MD¹, Yajur Arya, MD¹ and Ryan J Mayo, MD^3*

¹Albert Einstein Medical Center, Philadelphia, PA
²Albert Einstein Medical Center, Philadelphia
³Albert Einstein Medical Center, Allentown, PA

Chloe Merrion, MbChB BSc MRCP^1*, Ethan Troy-Barnes, MBBchBAO MRCP FRCPath^2*, Ryan Mullally, MRCP FRCPath^2,3*, Ana Ortuno Cabrero, MD^2*, John B. Porter^4,5* and Emma Drasar, MD, PhD^6,7*

¹Haematology, Whittington Health NHS Trust, London, United Kingdom
²Whittington Health NHS Trust, London, United Kingdom
³University College London Hospital, London, United Kingdom
⁴King’s College Hospital NHS Foundation Trust in partnership with Guys and St Thomas’ NHS Foundation Trust, National Haemoglobinopathy Panel, London, United Kingdom
⁵Research Department of Haematology, University College London Hospital, London, GBR
⁶Department of Haematology, Whittington Health NHS Trust, London, United Kingdom
⁷Haematology, University College London Hospital, London, United Kingdom

Jason N Payne, MD, MPH^1,2,3, Grace Kalmus, MPH^2*, Ashwin P. Patel, MD, PhD, MPH³, Amy Tang, MD^2,3, Marianne Yee, MD, MSc^2,3 and Beatrice E Gee, MD^1,2,3

¹Department of Pediatrics, Morehouse School of Medicine, Atlanta, GA
²Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA
³Department of Pediatrics, Emory University School of Medicine, Atlanta, GA

Saahil Patel, Medical Student^1*, Fiona Busser, Medical Student^1*, Caitlin Lu, BS^2*, Jennifer Light, MD^3* and Marwah Farooqui, DO⁴

¹Midwestern University CCOM, Downers Grove, IL
²University of Illinois, Chicago, IL
³University of Illinois College of Medicine - Peoria, Peoria, IL
⁴Division of Hematology/Oncology, University of Illinois Chicago, Chicago, IL

Shannon Ford, PhD^1,2*, Jhana Parikh, BS, MS^2,3*, Abhinav Gundala, MSc^2*, Caroline Vuong, MD^4*, Arvind Subramaniam, MSc^2,5*, Elizabeth Hensley, BS^2*, Olivia Fernandez^6* and Nirmish Shah, MD⁶

¹School of Nursing, University of North Carolina at Wilmington, Wilmington, NC
²Nanbar Health LLC, Winterville, NC
³Campbell School of Osteopathic Medicine, Campbell University, Lillington, NC
⁴Department of Pediatric Hematology, Amsterdam University Medical Center, Amsterdam, Netherlands
⁵ECU Brody School of Medicine, East Carolina University, Greenville
⁶Department of Medicine, Division of Hematology - Duke Sickle Cell Comprehensive Care Unit, Duke University Medical Center, Durham, NC

Ashna Jagtiani, MBBS, MPH^1*, Cynthia Sinha, PhD^2*, Ashleigh Hawk, MPH^3,4*, Scott Gillespie, MS, MSPH^1,5*, Mona Mirbeyk, MD^6*, Fuad El Rassi, MD⁷, Wally R Smith, MD⁸, Lakshmanan Krishnamurti, MD⁹, Soumitri Sil, PhD¹⁰ and Nitya Bakshi, MBBS, MS¹¹

¹Emory University, Atlanta, GA
²Emory University School of Medicine, Atlanta
³Department of Pediatrics, Division of Hematology, Oncology, and Bone Marrow Transplant, Emory University School of Medicine, Atlanta, GA
⁴Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA
⁵Children's Healthcare of Atlanta, Atlanta, GA
⁶Yale University, New Haven, CT
⁷Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA
⁸Division of General Internal Medicine, Department of Medicine, Virginia Commonwealth University, Richmond, VA
⁹Section of Pediatric Hematology/Oncology/BMT, Yale School of Medicine, Atlanta, GA
¹⁰Emory University/Children's Healthcare of Atlanta, Atlanta, GA
¹¹Yale School of Medicine, New Haven

Jahnavi Gollamudi, MD¹, Guolian Kang, PhD², Michael Sexton Lamonica^1*, Lindsey Hornung, MS^3*, Pei-Lin Chen, MPH^4*, Babette S Zemel, PhD^5* and Oyebimpe Adesina, MD, MS^6*

¹University of Cincinnati, Cincinnati, OH
²Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN
³Cincinnati Children's Hospital Medical Center, Cincinnati
⁴St. Jude Children’s Research Hospital, Memphis, TN
⁵The Children's Hospital of Philadelphia, Philadelphia, PA
⁶UC Davis Comprehensive Cancer Center, SACRAMENTO, CA

Aida Kidane, MD^1*, Marjolein Dremmen, MD^2*, Candace Makeda Moore, MD^3,4*, Isabelle van der Velpen, MD, PhD^5*, Marine Bouyssi-Kobar, PhD^5*, Anita W. Rijneveld, MD, PhD⁶, Tonya White, MD, PhD^7* and Marjon H. Cnossen, MD, PhD^8*

¹Erasmus Medical Center, Rotterdam, Netherlands
²Pediatric Radiology, Erasmus Medical Center Sophia's Children Hospital, Rotterdam, Netherlands
³Pediatric Hematology, Erasmus Medical Center Sophia's Children Hospital, Rotterdam, Netherlands
⁴eScience Center, Amsterdam, Netherlands
⁵National Institutes of Mental Health, Section on Social and Cognitive Developmental Neuroscience, Bethesda, MD
⁶Department of Hematology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, Netherlands
⁷Section on Social and Cognitive Developmental Neuroscience, National Institutes of Mental Health, Bethesda, MD
⁸Department of Pediatric Hematology and Oncology, Erasmus MC Sophia Children’s Hospital, Erasmus University Medical Center, Rotterdam, Netherlands

Angela Liu, MD¹, Sarah McCuskee, MD, MPhil^2*, Charleen Jacobs, MSN, ANP^3*, Paola Sebastiani, PhD^4*, Bin Zhang, PhD^5*, Jeffrey A. Glassberg, MD⁶ and Susanna Curtis, MD, PhD¹

¹Icahn School of Medicine at Mount Sinai, New York, NY
²Department of Emergency Medicine, Icahn School of Medicine at Mount Sinai, New York, NY
³Mount Sinai Center for Sickle Cell Disease, Mount Sinai Hospital, New York, NY
⁴Tufts Clinical and Translational Science Institute, Boston, MA
⁵Genetics and Genomic Sciences, Mount Sinai Center for Transformative Disease Modeling, New York, NY
⁶Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY

Ngowari Pokima, MD^1*, Khalil El-gharib, MD^2*, Zaid Khamis, MD^3*, Melissa Marseille, MD^4*, Praneeth Reddy Keesari, MD⁵, Mary Owolabi, MD^6*, Kai Wang, MD^1* and Marcel Odaimi, MD^7*

¹Staten Island University Hospital, Staten Island, NY
²Pulmonary and critical care, Robert Wood Johnson University Hospital, New Brunswick, NJ
³Staten Island University Hospital, Staten Island
⁴The Brooklyn Hospital Center, Brooklyn, NY
⁵Department of Internal Medicine, Staten Island University Hospital, Staten Island, NY
⁶Staten island university hospital, staten island, NY
⁷Staten island university hospital, Staten Island, NY

Ugo Boccadifuoco^1*, Ivan Lerner, MD^2,3,4*, Auria Godard, PhD^5,6*, Laure Joseph, MD^6,7*, Wassim El Nemer, PhD^5,6, Geoffrey Cheminet, MD^1,6,8* and Jean-Benoit Arlet, MD, PhD^1,6,8,9*

¹Department of internal medicine, French Sickle Cell Disease Referral Center, Hôpital Européen Georges Pompidou, AP-HP, Paris, France
²Department of Medical Informatics, Hôpital Européen Georges Pompidou, AP-HP, Paris, France
³Inserm, Centre de Recherche des Cordeliers, Sorbonne Université, Université Paris Cité, Paris, France
⁴HeKA, Inria Paris, Paris, France
⁵Établissement Français du Sang PACA-Corse, Aix Marseille Université, CNRS, UMR 7268 ADES, Marseille, France
⁶Laboratory of Excellence GR-Ex, Paris, France
⁷Biotherapy Department, French National Sickle Cell Referral Center, Hopital Necker, AP-HP, Paris, France
⁸Université Paris Cité, Inserm U1163, Imagine Institute, Laboratory "Molecular mechanisms of hematological disorders and therapeutic implications", Paris, France
⁹Université Paris Cité, Faculté de Santé, Paris, France