Chao Shen, PhD^1,2*, Tingting Tang^2,3*, Kitty Wang^2,3*, Zunsong Hu, PhD⁴, Yuan Che^2,3*, Meiling Chen^2,3*, Keren Zhou, PhD^3*, Zhenhua Chen, PhD^1,2*, Ying Qing, PhD^2,3*, Wei Li, PhD^2,3*, Dong Wu, PhD^2,3*, Keith Leung^2,3*, Lillian Sau^2,3*, Zhaoxu Xu^2,3*, Lucy Y. Ghoda^5,6*, Guido Marcucci^5,7, Xiaolan Deng, PhD^2,3* and Jianjun Chen, PhD^2,3,5,8

¹Department of Systems Biology, City of Hope, Arcadia, CA
²Center for RNA Biology and Therapeutics, City of Hope, Duarte, CA
³Department of Systems Biology, City of Hope, Monrovia, CA
⁴City of Hope, Duarte, CA
⁵Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA
⁶Department of Hematological Malignancies Translational Science, Gehr Family Center for Leukemia Research, City of Hope Medical Center and Beckman Research Institute, Duarte, CA
⁷Department of Hematologic Malignancies Translational Science, Duarte, CA
⁸Comprehensive Cancer Center, City of Hope, Duarte, CA

Wenjun Zhang, PhD^1*, Jinqin Liu^1*, Gang Huang, PhD^2,3, Zhijian Xiao, MD^4* and Bing Li, MD^1*

¹State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Tianjin, China
²Department of Cell Systems and Anatomy, UT Health San Antonio, San Antonio, TX
³Department of Pathology and Laboratory Medicine, UT Health San Antonio, San Antonio, TX
⁴State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences&Peking Union Medical College, Tianjin, China

Matteo Zampini, PhD^1,2*, Gabriele Todisco, MD^1,3*, Alice Chiodi, PhD^4*, Chiara Chiereghin, PhD^5*, Elena Saba, PhD^2*, Francesco Gandolfi, PhD^6*, Denise Ventura, MSc^2*, Nicole Pinocchio, MSc^2*, Laura Crisafulli, PhD^2,7*, Matteo Brindisi^2,7*, Alessia Campagna, MD^3*, Alberto Termanini, PhD^5*, Luca Lanino, MD², Marta Ubezio, MD^3*, Giulia Maggioni, MD^3*, Antonio Russo, MD^3*, Alessandro Buizza^1*, Elisabetta Sauta, PhD^8*, Gianluca Asti, MSc^3*, Saverio D'Amico, MSc^3*, Veronica Vallelonga^6*, Serena ML Ghisletti, PhD^6,9*, Ettore Mosca, PhD^4*, Francesca Ficara, PhD^3,7* and Matteo Giovanni Della Porta, MD^1,3*

¹Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy
²IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy
³IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
⁴Institute of Biomedical Technologies, National Research Council (CNR), Segrate, Italy
⁵Human Technopole, Milan, Italy
⁶Department of Experimental Oncology, European Institute of Oncology (IEO),IRCCS, Milan, Italy
⁷Institute for Genetic and Biomedical Research, Milan Unit, CNR, Milan, Italy
⁸Humanitas Research Hospital, IRCCS, Rozzano, Italy
⁹Dipartimento di Scienze Farmacologiche e Biomolecolari, Universita' degli studi di Milano, Milan, Italy

Junying Wu^1*, Jinqin Liu^1*, Lin Yang, PhD^1*, Bing Li, MD^1,2*, Chen Jia^3*, Fuhui Li^1*, Robert Peter Gale, MD⁴ and Zhi-jian Xiao^1,5*

¹State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Tianjin, China
²MDS and MPN Centre, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Jinan, China
³State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Tianjin Key Laboratory of Gene Therapy for Blood Diseases, CAMS Key Laboratory of Gene Therapy for Blood Diseases, Tianjin, China
⁴University of California, Los Angeles, Los Angeles, CA
⁵MDS and MPN Centre, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China

Kelly Lim, MSc, BSc^1,2*, Monika Kutyna, PhD^3,4*, Winnie Kan, PhD^5*, Angel F. Lopez, MBBS, PhD^2,5*, Anna Brown, PhD^6*, Agnes S. M. Yong, MD, PhD^1,7, Steven W Lane, MBBS, PhD, FRCPA, FRACP^8,9, Chun Yew Fong, MBBS, FRACP, FRCPA, PhD^10*, Timothy P Hughes, MD, MBBS, FRACP, FRCPA⁴, David T Yeung, MBBS, PhD, BSc, FRACP, FRCPA^3,4, David M Ross, MD, PhD, FRACP, FRCPA^1,2,3,6,11*, Devendra Hiwase, MD, MBBS, PhD, FRACP, FRCPA^3,4,12 and Daniel Thomas, MD, PhD, FRACP, FRCPA^2,4,13

¹South Australian Health and Medical Research Institute, Adelaide, Australia
²Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia
³Department of Haematology, Central Adelaide Local Health Network, Adelaide, SA, Australia
⁴South Australian Health and Medical Research Institute, Adelaide, SA, Australia
⁵Cytokine Receptor Laboratory, SA Pathology, Adelaide, SA, Australia
⁶SA Pathology, Adelaide, SA, Australia
⁷Haematology Department, Royal Perth Hospital, Perth, Australia
⁸Cancer Program, QIMR Berghofer Medical Research Institute, Royal Brisbane and Women’s Hospital, Brisbane, QLD, Australia
⁹Royal Brisbane and Women’s Hospital, Brisbane, QLD, Australia
¹⁰Department of Hematology, Austin Health, Heidelberg, VIC, Australia
¹¹College of Medicine and Public Health, Flinders Health and Medical Research Institute, Adelaide, SA, Australia
¹²University of Adelaide, Adelaide, SA, Australia
¹³Central Adelaide Local Health Network, Adelaide, SA, Australia

Terra L. Lasho, PhD¹, Jenna A. Fernandez, PhD², Jeong-Heon Lee, PhD^3*, Linh D. Pham^3*, Huihuang Yan, PhD^4*, Christy Finke, BS^2*, Abhishek A. Mangaonkar, MBBS¹, Aref Al-Kali, MD², Naseema Gangat, MBBS², Joseph Collard^5*, Claes Wahlestedt, MD PhD^5*, Mrinal M. Patnaik, MD, MBBS¹ and Moritz Binder, MD²

¹Mayo Clinic, Rochester, MN
²Division of Hematology, Mayo Clinic, Rochester, MN
³Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
⁴Division of Computational Biology, Mayo Clinic, Rochester, MN
⁵Epigenetix Inc., Delray Beach, FL

Gabriele Todisco, MD^1,2,3*, Matteo Zampini, PhD^4*, Pedro Luis Moura, PhD^2*, Alessandro Buizza^5*, Teresa Mortera-Blanco, PhD^2*, Anna Tranberg, MD^2*, Elena Riva, PhD^4*, Maria Creignou, MD, PhD^2*, Alessia Campagna, MD^3*, Marta Ubezio, MD^3*, Ann-Charlotte Björklund^2*, Bianca Tesi, MD, PhD^2*, Indira Barbosa^2*, Denise Ventura, MSc^4*, Francesca Ficara, PhD^3,6*, Elli Papaemmanuil⁷, Armando Santoro, MD^1,5*, Magnus Tobiasson, MD^2*, Elsa Bernard, PhD^8*, Matteo Giovanni Della Porta, MD^1,3* and Eva Hellstrom Lindberg, MD, PhD^2*

¹Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy
²Center for Hematology and Regenerative Medicine (HERM), Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden
³IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
⁴IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy
⁵IRCCS Humanitas Research Hospital, Rozzano, Italy
⁶Institute for Genetic and Biomedical Research, Milan Unit, CNR, Milan, Italy
⁷Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY
⁸Precision Medicine Cancer Center, Gustave Roussy, Villejuif, France

Serhan Unlu, MD¹, Christopher Haddad^2*, Tariq Kewan, MD³, Olisaemeka Ogbue, MBBS¹, Arda Durmaz, PhD^4*, Waled Bahaj, MD⁵, Arooj Ahmed, MD^1*, Carlos Bravo-Perez, MD^1,6*, Luca Guarnera, MD⁷, Hetty E. Carraway, MD, MBA⁸, Yasuo Kubota, MD, PhD^1*, Carmelo Gurnari, MD, PhD¹, Torsten Haferlach, MD⁹, Valeria Visconte, PhD¹⁰ and Jaroslaw Maciejewski¹¹

¹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
²Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Westlake, OH
³Department of Internal Medicine, Section of Hematology, Yale University, New Haven, CT
⁴Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, CLEVELAND, OH
⁵Translational Hematology and Oncology Research, Cleveland Clinic, Cleveland, OH
⁶Department of Hematology and Medical Oncology, Hospital Universitario Morales Meseguer, University of Murcia, IMIB-Pascual Parrilla, CIBERER - Instituto de Salud Carlos III, Murcia, Spain
⁷Tor Vergata University, Rome, Italy
⁸Department of Hematology and Medical Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH
⁹MLL Munich Leukemia Laboratory, Munich, Germany
¹⁰Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Taussig Cancer Institute, Cleveland, OH
¹¹Department of Hematology and Medical Oncology, Taussig Cancer Institute, Leukemia Program, Cleveland Clinic, Cleveland

Megha Verma^1*, Matthew P Davidsohn^2*, Srabani Sahu, MS^3*, Kith Pradhan, PhD^4*, Seyedeh Shareh Dehghani^1*, Sakshi Jasra, MD^5*, Ritesh Aggarwal, PhD^6*, Hui Zhang^7*, Michael Wysota, MD⁸, Divij Verma, PhD³, Amit Verma, MBBS^2*, Dean Hosgood, PhD^2*, Yiyu Zou^2* and Aditi Shastri, MD⁹

¹Albert Einstein College of Medicine, Bronx
²Albert Einstein College of Medicine, Bronx, NY
³Blood Cancer Institute, Department of Oncology, Albert Einstein College of Medicine, Bronx, NY
⁴Department of Oncology, Blood Cancer Institute, Albert Einstein College of Medicine, Bronx, NY
⁵Department of Hematology and Oncology, The University of Vermont Medical Center, Burlington, VT
⁶Montefiore Einstein Cancer Center, Blood Cancer Institute, Department of Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY
⁷Albert Einstein College of Medicine, New York, NY
⁸Montefiore Medical Center, New York, NY
⁹Montefiore Einstein Comprehensive Cancer Center, Blood Cancer Institute, Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY