Deepti H. Radia, MD^1*, Tsewang Tashi, MD, PhD^2*, Ivan Alvarez-Twose, MD, PhD^3*, Patrizia Bonadonna, MD^4*, Hanneke Oude Elberink, MD, PhD^5*, Sonia Cerquozzi, MD⁶, Tracy I. George, MD^7,8, Guang Yang, PhD⁹, Mark Rosenzweig, PhD^9*, Hui-Min Lin, PhD^9*, Ben Lampson, MD, PhD^9*, Rachel L. Erlich, PhD^9* and Jason Gotlib, MD, MS¹⁰

¹Guy’s Hospital London, Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom
²Division of Hematology and Hematologic Malignancies, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT
³Spanish Reference Center of Mastocytosis, Institute of Mastocytosis Studies of Castilla-La Mancha, Toledo, Spain
⁴Department of Medicine, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy
⁵Department of Allergology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
⁶Division of Hematology and Hematologic Malignancies, University of Calgary, Calgary, Canada
⁷ARUP Laboratories, University of Utah, Salt Lake City, UT
⁸Huntsman Cancer Institute, University of Utah, Salt Lake City, UT
⁹Blueprint Medicines Corporation, Cambridge, MA
¹⁰Stanford Cancer Institute/Stanford University School of Medicine, Stanford, CA

Yi Zhang^1*, Hu Zhou², Shanshan Suo, MD^1*, Junling Zhuang, MD, PhD³, Linhua Yang, MD^4*, Aili He, PhD, MD^5*, Qingchi Liu^6*, Xin Du, PhD⁷, Sujun Gao^8*, Yarong Li^9*, Yan Li^10*, Yuqing Chen^11*, Wen Wu^12*, Huanling Zhu^13*, Guangsheng He^14*, Mei Hong, MD^15*, Qian Jiang, MD¹⁶, Zhongxing Jiang^17*, Hongmei Jing¹⁸, Jishi Wang, PhD¹⁹, Na Xu^20*, Lingling Yue^21*, Cuiping Zheng^22*, ZePing Zhou, MD, PhD²³, Chenghao Jin^24*, Xin Li^25*, Lin Liu^26*, Yajing Xu, MD^27*, Dengshu Wu^28*, Feng Zhang^29*, Jin Zhang^30*, Zhijian Xiao, MD^31* and Jie Jin, M.D.³²

¹Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
²Department of Hematology, Henan Provincial Cancer Hospital, Zhengzhou, China
³Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, China
⁴The Second Hospital of Shanxi Medical University, Taiyuan, China
⁵Department of Hematology, The Second Affiliated Hospital of Xi’an Jiao Tong University, Xi'an Key Laboratory of Hematological Diseases, Xi’an, China
⁶The First Hospital of Hebei Medical University, Shijiazhuang, China
⁷Department of Hematology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, WA, China
⁸Department of Hematology, The First Hospital of Jilin University, Changchun, China
⁹Department of Hematology and Oncology, The Second Hospital of Jilin University, Changchun, CHN
¹⁰Department of Hematopathology, The First Affiliated Hospital of China Medical University, Shenyang, China
¹¹Department of Hematology, Henan Province People's Hospital, Zhengzhou, China
¹²Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
¹³Department of Hematology, West China Hospital, Sichuan University, Chengdu, China
¹⁴The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Key Laboratory of Hematology of Nanjing Medical University, Collaborative Innovation Center for Cancer Personalize, Nanjing, China
¹⁵Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
¹⁶National Clinical Research Center for Hematologic Disease, Peking University People’s Hospital, Peking University Institute of Hematology, Beijing, Beijing, China
¹⁷The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
¹⁸Peking University Third Hospital, Beijing, CHN
¹⁹Department of Hematology, Affiliated Hospital of Guizhou Medical University, Guiyang City, China
²⁰Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China
²¹Department of Hematology and Oncology, Lanzhou University Second Hospital, Lanzhou, China
²²Second Department of Oncology, Wenzhou Central Hospital, Wenzhou, China
²³Second Affiliated Hospital of Kunming Medical University, Kunming, China
²⁴Jiangxi Provincial People's Hospital, Nanchang, China
²⁵Department of Hematology, Third Xiangya Hospital of Central South University, Changsha, China
²⁶Department of Hematology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
²⁷Xiangya Hospital, Central South University, Changsha, Hunan, China
²⁸Department of Hematology, Xiangya Hospital, Central South University, Changsha, China
²⁹Department of Hematology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China
³⁰Department of Hematology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
³¹MDS and MPN Centre, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
³²Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China

He Lin^1*, Xin-xin Cao^1*, Long Chang^1*, Min Lang^1*, Zheng-Zheng Liu^1*, Minghui Duan^1*, Daobin Zhou, MD^2* and Wen Gao³

¹Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
²Department of Hematology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China
³Department of Hematology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

Corentin Orvain^1*, Suzanne Tavitian, MD^2*, Clemence Mediavilla, MD^3*, Francoise Boyer, MD^4*, Alberto Santagostino^5*, Geoffroy Venton^6*, Samia Madene^7*, Tony Marchand, MD, PhD^8*, Pascal Turlure, MD^9*, Diane Lara^10*, Lenaïg Le Clech^11*, Katell Le Du^12*, Jean-Baptiste Robin^13*, Lise Willems^14*, Anaise Blouet^15*, Thomas Systchenko^16*, Mathieu Wemeau, MD^17*, Hélène Pasquer, M.D.^18*, Melanie Mercier^19*, Christophe Nicol^20*, Laurence Legros, MD, PhD^21*, Antoine Machet, MD^22*, Franck E. Nicolini, MD, PhD²³, Lydia Roy, MD^24*, Clémentine Salvado^25*, Guillaume Denis^26*, Elsa Lestang^27*, Kamel Laribi^28*, Eric Lippert^29*, Lina Benajiba, MD, PhD³⁰ and Jean-Christophe Ianotto, MD, PhD, HDR^31*

¹Hematology Clinic, Angers University Hospital, Angers, France
²Department of Hematology, Toulouse University Cancer Institute Oncopole, Toulouse University Hospital, Toulouse, France
³Hematology Department, CHU de Bordeaux, Bordeaux, France
⁴Department of Hematology, Angers University Hospital, Angers, France
⁵Service d’Hématologie Clinique, Centre Hospitalier de Troyes, Troyes, France
⁶Hôpital de la Timone, Service Hématologie et Thérapie Cellulaire, Centre d’Essais Précoces en Cancérologie de Marseille (CEPCM), Marseille, France
⁷CH Mont -de-Marsan, Mont-de-Marsan, FRA
⁸Hematology Clinic, Rennes University Hospital, Rennes, France
⁹Service d'Hématologie Clinique, CHU de Limoges, Limoges, France
¹⁰Centre Hospitalier de Libourne, Libourne, France
¹¹Centre Hospitalier De Cornouaille, Quimper, FRA
¹²Hôpital privé du Confluent, Nantes, FRA
¹³CH Bayonne, Bayonne, France
¹⁴Hôpital Cochin, PARIS, FRA
¹⁵Strasbourg Oncologie Libérale, Clinique Sainte-Anne, Strasbourg, France
¹⁶Poitiers University Hospital, Poitiers, France
¹⁷Department of Hematology, Roubaix Hospital, Roubaix, France
¹⁸St Louis Hospital, INSERM U944, PARIS, FRA
¹⁹Centre Hospitalier Bretagne Atlantique, Vannes, FRA
²⁰Morlaix Hospital, Morlaix, France
²¹Service d’Hématologie-Clinique Ambulatoire (SHCA), APHP, Hôpital Bicêtre, Le Kremlin-Bicêtre, France
²²Tours University Hospital, Tours, France
²³Hematology Department, Centre Leon Berard, LYON Cedex 03, France
²⁴Hematology Department, Henri Mondor University Hospital, UPEC, IMRB, Assistance Publique Hopitaux de Paris, Créteil, France
²⁵Dax Hospital, Dax, France
²⁶Rochefort Hospital, Rochefort, France
²⁷Saint Nazaire Hospital, Saint Nazaire, France
²⁸Hématologie Clinique, CH Le Mans, Le Mans, France
²⁹Brest University Hospital, Brest, France
³⁰INSERM UMR944, Institut de Recherche Saint-Louis, Paris, France
³¹Hematology department, Centre Hospitalier Universitaire de Brest, Brest, France

Edouard Long^1*, Roberta Dunn^2*, Laura Li Gagnon, MD^3*, Claire Harrison⁴, Yunfan Yang, MD^3,5* and Jennifer O'Sullivan^6*

¹GKT School of Medical Education, King’s College London, London, ENG, United Kingdom
²GKT School of Medical Education, King's College London, London, United Kingdom
³Department of Haematology, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom
⁴Department of Haematology, Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom
⁵Department of Hematology, West China Hospital of Sichuan University, Chengdu, China
⁶Department of Clinical Haematology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom

Ayalew Tefferi, MD¹, Giuseppe Gaetano Gaetano Loscocco^2*, Maymona Abdelmagid, MD^3*, Animesh D. Pardanani, MBBS, PhD³, Kebede Begna, MD³, Mrinal M. Patnaik, MD, MBBS⁴, Natasha Szuber, MD, MSc⁵, Alessandra Carobbio^6*, Tiziano Barbui, MD^7*, Kaaren K. Reichard, MD⁸, Paola Guglielmelli, MD⁹, Naseema Gangat, MBBS¹ and Alessandro M. Vannucchi, MD²

¹Division of Hematology, Mayo Clinic, Rochester, MN
²CRIMM, Center for Research and Innovation of Myeloproliferative Neoplasms, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy
³Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN
⁴Mayo Clinic, Rochester, MN
⁵Institut universitaire d'hématologie-oncologie et de thérapie cellulaire, Université de Montréal, Montreal, QC, Canada
⁶Fondazione per la Ricerca Ospedale di Bergamo (FROM), Bergamo, Italy
⁷FROM Research Foundation ASST Papa Giovanni XXIII Bergamo, Bergamo, ITA
⁸Department of Pathology, Mayo Clinic, Rochester, MN
⁹University of Florence, Firenze, Florence, ITA

Seug Yun Yoon^1*, Jong-Ho Won, MD², Sung-Eun Lee, MD, PhD^3*, Sung-Soo Yoon, M.D., Ph.D.⁴, Deok-Hwan Yang, MD, PhD^5*, Gyeong Won Lee^6*, Sang Kyun Sohn, MD, PhD^7*, Ho-Jin Shin, MD^8*, Sung Hwa Bae, MD^9*, Chul Won Choi^10*, Yunsuk Choi, MD, PhD¹¹, June-won Cheong, MD, PhD¹², Soo-Mee Bang, MD, PhD¹³, Joon Seong Park, MD^14*, Sukjoong Oh, MD¹⁵, Yong Park, MD, PhD¹⁶ and Young Hoon Park^17*

¹Division of Hematology & Medical Oncology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea, Republic of (South)
²Division of Hematology & Medical Oncology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, KOR
³Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Houston, TX
⁴Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of (South)
⁵Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Hwasun, Korea, Republic of (South)
⁶Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University College of Medicine, Jinju, Korea, Republic of (South)
⁷Department of Hematology/Oncology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, Korea, Republic of (South)
⁸Division of Hematology-Oncology, Department of Internal Medicine, Biochemical Research Institution, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea, Republic of (South)
⁹Department of Internal Medicine, Daegu Catholic, University Hospital, Daegu Catholic University School of Medicine, Daegu, KOR
¹⁰Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea, Republic of (South)
¹¹Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of (South)
¹²Severance Hospital, Yonsei University College of Medicine, Seoul, KOR
¹³Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea, Republic of (South)
¹⁴Department of Hematology-Oncology, Ajou University School of Medicine, Suwon, Korea, Republic of (South)
¹⁵Hanyang University Medical Center, Seoul, KOR
¹⁶Division of Hematology-Oncology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea, Republic of (South)
¹⁷Ewha Womans University Mokdong Hospital, Seoul, Korea, Republic of (South)

Fnu Aperna, MBBS^1*, Moazah Iftikhar, MBBS^1*, Masooma S Rana, MBBS^1*, Animesh D. Pardanani, MBBS, PhD¹, Paola Guglielmelli, MD², Alessandro Maria Vannucchi³, Naseema Gangat, MBBS⁴, Ayalew Tefferi, MD⁴ and Giuseppe Gaetano Loscocco^1,3*

¹Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN
²Department of Experimental and Clinical Medicine, Centro di Ricerca e Innovazione Malattie Mieloproliferative (CRIMM), AOU Careggi, University of Florence, Florence, Italy
³Department of Experimental and Clinical Medicine, CRIMM, Center of Research and Innovation of Myeloproliferative Neoplasms, Azienda Ospedaliero-Universitaria Careggi, University of Florence, Florence, Italy
⁴Division of Hematology, Mayo Clinic, Rochester, MN

Alexander Gazda, MD^1*, Di Pan, DO^2*, Katie Erdos^3*, Ghaith Abu-Zeinah, MD³, Alexandra Racanelli, MD, PhD^2*, Evelyn Horn, MD^4* and Joseph M. Scandura, MD, PhD³

¹Division of Pulmonary and Critical Care, Department of Medicine, Weill Cornell Medical College, New York, NY
²Weill Cornell Medical College, New York, NY
³Richard T. Silver, MD Myeloproliferative Neoplasms Center, Weill Cornell Medicine, New York, NY
⁴Greenberg Cardiology Division, Department of Medicine, Weill Cornell Medical College, New York, NY

Resham Mawalkar, bsc¹, Hua-Ling Tsai, Sc.M^2*, Terra Marie M Jouaneh, MS^1*, Shivam Patel, BS^1*, Christopher Gocke, MD^3*, Eitan Halper-Stromberg, MD, PhD^4*, Rena R. Xian, MD⁵, K. C. Rappazzo, MD^6*, Evan M. Braunstein, MD, PhD⁷, Alison R. Moliterno, MD⁸ and Tania Jain, MD⁹

¹Johns Hopkins University School of Medicine, Baltimore, MD
²Division of Biostatistics, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD
³Johns Hopkins Medical Institutions, Baltimore, MD
⁴Director of Cancer Genetics Lab, Johns Hopkins University School of Medicine, Baltimore, MD
⁵Division of Hematopathology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD
⁶Division of Hematology, Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD
⁷Johns Hopkins University, Baltimore, MD
⁸Division of Hematology, Department of Medicine, Johns Hopkins University/Fda, Silver Spring, MD
⁹Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD

Marion Divoux, MD^1,2*, Ghislain Fievet^3*, Natacha Dreumont, PhD^3*, Laurence Schenone, MD^4*, Maud D'Aveni, MD, PhD^5*, Francois Girodon, MD, PhD^6*, Pierre Feugier, MD, PhD^2,4*, Sébastien Hergalant, PhD^3* and Julien Broséus, MD, PhD^4,7*

¹UMR Inserm 1256 NGERE (Nutrition, Génétique et Exposition aux Risques Environnementaux), Université de Lorraine, Faculté de médecine, Vandoeuvre, France
²Department of Haematology, Centre Hospitalier Régional Universitaire (CHRU) de Nancy, Vandoeuvre-lès-Nancy, France
³UMR Inserm 1256 NGERE (Nutrition, Génétique et Exposition aux Risques Environnementaux), Université de Lorraine, Faculté de médecine, Vandoeuvre-lès-Nancy, France
⁴UMR Inserm 1256 NGERE (Nutrition, Génétique et Exposition aux Risques Environnementaux), Université de Lorraine, Faculté de médecine, vandoeuvre-lès-nancy, France
⁵Department of Haematology,, Centre Hospitalier Régional Universitaire (CHRU) de Nancy, Vandoeuvre-les-Nancy, France
⁶Laboratory of Biological Hematology, University Hospital of Dijon, Dijon, France
⁷Laboratory of Biological Hematology,, Centre Hospitalier Régional Universtaire de Nancy, vandoeuvre-lès-nancy, France

Yuhui Zhang^1*, Guangshuai Teng^1*, Yifan Duan^1*, Chenxiao Du^1*, Yan Wang^1*, Huiqin Zhang^1*, Xin Hu^1*, Yunhan Zhao^1*, Yuan Zhou^2*, Weiping Yuan^1,2 and Jie Bai, MD³

¹Department of Hematology, the Second Hospital of Tianjin Medical University, Tianjin, China
²State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, National Clinical Research Center for Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
³Institute of Hematology &blood Disease Hospital, Tianjin City, Tianjin City, China

Moazah Iftikhar, MBBS^1*, Masooma S Rana, MBBS^1*, Yamna Jadoon, MBBS², Maymona Abdelmagid, MD^1*, Kaaren K. Reichard, MD³, Cinthya Zepeda Mendoza, PhD^4*, Animesh D. Pardanani, MBBS, PhD¹, Ayalew Tefferi, MD⁵ and Naseema Gangat, MBBS⁵

¹Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN
²UMass Chan Medical School Baystate, Broad Brook, CT
³Department of Pathology, Mayo Clinic, Rochester, MN
⁴Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester
⁵Division of Hematology, Mayo Clinic, Rochester, MN

Sangam Sangam, MD¹, Tripti Jain, MD^2*, Marco Bermudez, MD^3*, Yemesrach Mekonen^1*, Francisco Gallegos Koyner, MD^3* and Shorabh Sharma, MD^1*

¹Department of Medicine, SBH Health System, Bronx, NY
²Rochester General Hospital, Rochester, NY
³Department of Medicine, SBH Health System, Bronx

John O. Mascarenhas, MD¹, Sebastian Grosicki, MD, PhD^2*, Dominik Chraniuk, MD^3*, Elisabetta Abruzzese, MD⁴, Prithviraj Bose, MD⁵, Aaron T. Gerds, MD, MS⁶, Alessandro M. Vannucchi, MD, PhD⁷, Francesca Palandri, MD, PhD^8*, Sung-Eun Lee, MD, PhD^9*, Vikas Gupta, MD, FRCP, FRCPath¹⁰, Alessandro Lucchesi, MD, PhD^11*, Stephen Oh, MD, PhD¹², Andrew T. Kuykendall, MD¹³, Andrea Patriarca, MD^14*, Alberto Alvarez-Larran^15*, Ruben Mesa, MD^16*, Jean-Jacques Kiladjian, MD, PhD¹⁷, Moshe Talpaz, MD¹⁸, Morgan Harris, PharmD^19*, Sarah-Katharina Kays, PhD^20*, Qing Li, PhD^21*, Barbara Brown, PhD^19*, Anna-Maria Jegg, PhD^20*, Claire Harrison²² and Raajit Rampal, MD, PhD²³

¹Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
²Medical University of Silesia, Katowice, Poland
³Hematology Ward, Wojewódzki Szpital Zespolony im. L. Rydygiera, Torun, Poland
⁴Department of Hematology, S. Eugenio Hospital, Tor Vergata University, ASL Roma 2, Roma, I, Italy
⁵Leukemia Department, University of Texas MD Anderson Cancer Center, Houston, TX
⁶Cleveland Clinic Taussig Cancer Institute, Cleveland, OH
⁷Department of Clinical and Experimental Medicine, University of Florence, Florence, Italy
⁸IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico S. Orsola-Malpighi, Istituto di Ematologia "Seràgnoli", Bologna, Italy
⁹Department of Hematology,, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)
¹⁰The Princess Margaret Cancer Centre, Toronto, ON, Canada
¹¹Hematology Unit, IRCCS Istituto Romagnolo per lo Studio e la Cura dei Tumori (IRST) “Dino Amadori”, Meldola (FC), Italy
¹²Washington University School of Medicine in St. Louis, St. Louis, MO
¹³Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL
¹⁴Hematology Unit, AOU Maggiore della Carità and University of Eastern Piedmont, Novara, Italy
¹⁵Hematology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
¹⁶Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, NC
¹⁷Clinical Investigation Center, Hôpital Saint-Louis, Université de Paris, Paris, France
¹⁸University of Michigan Comprehensive Cancer Center, Ann Arbor, MI
¹⁹Constellation Pharmaceuticals, a MorphoSys Company, Boston, MA
²⁰MorphoSys AG, Planegg, Germany
²¹MorphoSys US Inc, Boston, MA
²²Department of Haematology, Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom
²³Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY

Lindsay A.M. Rein, MD¹, Firas El Chaer, MD², Junichiro Yuda, MD, PhD³, Kazuya Shimoda, MD, PhD⁴, Raajit Rampal, MD, PhD⁵, Joseph M. Scandura, MD, PhD⁶, Akiyoshi Takami, MD, PhD⁷, James McCloskey, MD⁸, Michiko Ichii, MD, PhD^9*, Shuichi Shirane, MD, PhD^10*, Alessandra Iurlo, MD, PhD^11*, Prithviraj Bose, MD¹², Alessandro Lucchesi, MD, PhD^13*, Giulia Benevolo, MD^14*, Idoroenyi Amanam, MD¹⁵, Pankit Vachhani, MD^16*, Srinivas K Tantravahi, MD¹⁷, Marcello Rotta, MD^18*, Yasushi Onishi, MD, PhD^19*, Jean-Jacques Kiladjian, MD, PhD²⁰, Ciro Rinaldi, MD, PhD^21*, Nikki Granacher, MD^22*, Terrence Bradley, MD²³, Anand Ashwin Patel, MD²⁴, Michael Loschi, MD, PhD^25*, Samah Alimam, MD, PhD^26*, Stanley Cheung, MD, PhD^27*, Vincent Ribrag, MD²⁸, Sujan Kabir, MD^29*, Masataka Seki, MS^29*, Karen Ansaldo, PharmD^29*, Guia Guffanti, PhD^29*, Jinny Lee, PhD^29*, Steven L. Warner, PhD²⁹, Jason M. Foulks, PhD²⁹ and Ruben Mesa, MD^30*

¹Duke University Medical Center, Durham, NC
²University of Virginia Health System, Charlottesville, VA
³National Cancer Center Hospital East, Kashiwa, Japan
⁴Division of Hematology, Diabetes, and Endocrinology, Department of Internal Medicine, University of Miyazaki, Miyazaki, Japan
⁵Memorial Sloan Kettering Cancer Center, New York, NY
⁶Weill Cornell Medicine, New York, NY
⁷Aichi Medical University School of Medicine, Nagakute, Japan
⁸John Theurer Cancer Center at Hackensack Meridian Health, Hackensack, NJ
⁹Osaka University Graduate School of Medicine, Suita, Japan
¹⁰Juntendo University School of Medicine, Bunkyo-ku, Japan
¹¹Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
¹²The University of Texas MD Anderson Cancer Center, Houston, TX
¹³IRCCS Istituto Romagnolo per lo Studio e la Cura dei Tumori (IRST) “Dino Amadori”, Meldola, Italy
¹⁴AOU Città della Salute e della Scienza, Turin, Italy
¹⁵City of Hope National Medical Center, Duarte, CA
¹⁶University of Alabama at Birmingham, Birmingham, AL
¹⁷Huntsman Cancer Institute, Salt lake city, UT
¹⁸Colorado Blood Cancer Institute, Denver, CO
¹⁹Tohoku University Hospital, Sendai, Japan
²⁰Hopital Saint-Louis, Paris, France
²¹Pilgrim Hospital Boston, Boston, United Kingdom
²²ZNA Middelheim, Antwerp, Belgium
²³University of Miami Health System, Miami, FL
²⁴University of Chicago, Chicago, IL
²⁵CHU de Nice - Hôpital L'Archet 1, Nice, France
²⁶University College of London Hospitals NHS Foundation Trust, London, United Kingdom
²⁷ICON Cancer Care, Kurralta Park, Australia
²⁸Institut Gustave Roussy, Villejuif, France
²⁹Sumitomo Pharma America, Inc., Marlborough, MA
³⁰Atrium Health Levine Cancer Institute, Charlotte, NC

Jian Huang, MD, PhD^1,2, Bingbing Wen^1,3*, Tiejun Gong^4*, Hu Zhou⁵, Lihong Shou^6*, Qingchi Liu^7*, Feng Zhang^8*, Cuicui WU^9*, Wei Yang^10*, Lidong Zhao^11*, Lili Chen, PhD^12*, Jian Lu^13*, Yile Zhou, MD^1,2*, Yi Zhang^1,2* and Jie Jin, M.D.^2,14

¹Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
²Zhejiang Provincial Clinical Research Center for Hematological disorders, Hangzhou, China
³The second hospital of shenzhen, Shenzhen, China
⁴Harbin Institute of Hematology and Oncology, Harbin First Hospital, Harbin, China
⁵Department of Hematology, Henan Provincial Cancer Hospital, Zhengzhou, China
⁶Department of Hematology, Huzhou Central Hospital, The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Huzhou, China
⁷The First Hospital of Hebei Medical University, Shijiazhuang, China
⁸The First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui, China
⁹Hematology, Yueyang People's Hospital, HUNAN, China
¹⁰Department of Hematology, Shengjing Hospital affiliated to China Medical University, Shenyang, China
¹¹The First People’s Hospital of Lianyungang, Lianyungang, Jiangsu, China
¹²Taizhou First People’s Hospital, Taizhou, China
¹³Hangzhou Biosun Pharmaceutical Co., LTD, Hangzhou, Zhejiang, China
¹⁴Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China

Dongni Yi, MD^1*, Ronald S Go, M.D.², Gordon J Ruan, M.D.², N. Nora Bennani, MD², Mithun V Shah, M.D., Ph.D.², Karen L Rech, M.D.^3*, Aishwarya Ravindran, M.B.B.S.^4*, Jay H Ryu, M.D.^5*, Robert Vassallo, M.D.^5*, Matthew J Koster, M.D.^6*, Caroline J Davidge-Pitts, M.B., B.Ch.^7*, Lucinda M Gruber, M.D.^7*, William Oliver Tobin, M.B., B.Ch., B.A.O., Ph.D.^8*, Julio C Sartori Valinotti, M.D.^9*, Talal Hilal, MD¹⁰, Liuyan Jiang, M.D.¹¹, Muhamad Alhaj Moustafa, M.D., M.S.¹², Asra Z. Ahmed, M.D.¹³, Gaurav Goyal, MD¹⁴ and Jithma P Abeykoon, MD²

¹Department of Internal Medicine, Mayo Clinic, Rochester, MN
²Division of Hematology, Mayo Clinic, Rochester, MN
³Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
⁴Department of Laboratory Medicine, University of Alabama at Birmingham, Birmingham, AL
⁵Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN
⁶Division of Rheumatology, Mayo Clinic, Rochester, MN
⁷Division of Endocrinology, Mayo Clinic, Rochester, MN
⁸Department of Neurology, Mayo Clinic, Rochester, MN
⁹Department of Dermatology, Mayo Clinic, Rochester, MN
¹⁰Division of Hematology, Mayo Clinic, Phoenix, AZ
¹¹Department of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL
¹²Division of Hematology, Mayo Clinic, Jacksonville, FL
¹³Division of Hematology and Medical Oncology, University of Michigan, Ann Arbor, MI
¹⁴Division of Hematology and Medical Oncology, University of Alabama at Birmingham, Birmingham, AL

Dandan Yu^1*, Hong-Ju Zhang^2*, Yanyan Song^2*, Yuan Tao^2*, Fengyuan Zhou^3*, Ziyi Wang^3*, Rongfeng Fu, MD^4*, Ting Sun^4*, Huan Dong^4*, Wenjing Gu^4*, Renchi Yang^4*, Zhijian Xiao, MD^5*, Qi Sun^6* and Lei Zhang^4,7

¹Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, AL, China
²State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, People’s Republic of China, Tianjin, China
³XY AI Technologies (Su Zhou) Limited, Jiangsu 215422, China, Jiangsu, China
⁴Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
⁵Hematologic Pathology Center, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
⁶Department of Pathology, Institute Of Hematology & Blood Diseases Hospital, Chinese Academy Of Medical Science & Peking Union Meical College, Beijing, China
⁷Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, China, Tianjin, China

Yael Kusne, MD, PhD¹, Talha Badar, MD², Terra L. Lasho, PhD³, Ludovica Marando, MD, PhD⁴, Abhishek A. Mangaonkar, MBBS⁴, Christy Finke, BS^3*, James M. Foran, MD⁵, Aref Al-Kali, MD⁴, Hassan B Alkhateeb, MD^3*, Naseema Gangat, MBBS³, Jeanne Palmer, MD⁶, David Viswanatha, MD⁷, Mark R. Litzow, MD³, Animesh D. Pardanani, MBBS, PhD⁸, Ayalew Tefferi, MD³, Timothy Chlon, PhD⁹, Alejandro Ferrer, PhD⁴ and Mrinal M. Patnaik, MD, MBBS⁴

¹Mayo Clinic, Phoenix, AZ
²Department of Hematology/Oncology, Mayo Clinic, Jacksonville, FL
³Division of Hematology, Mayo Clinic, Rochester, MN
⁴Mayo Clinic, Rochester, MN
⁵Division of Hematology & Medical Oncology, Mayo Clinic, Jacksonville, FL
⁶Mayo Clinic - Arizona, Scottsdale, AZ
⁷Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester
⁸Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN
⁹Cincinnati Children's Hospital Medical Center, Cincinnati, OH

Isabella Diana Hansen^1,2*, Morten Kranker Larsen, MSc^1,3*, Vibe Skov^1*, Lasse Kjær^1*, Christina Ellervik^3,4,5,6*, Anders Lindholm Sørensen^1*, Trine Alma Knudsen¹, Sarah Friis Christensen^1*, Sabrina Cordua^1*, Christina Schjellerup Eickhardt-Dalbøge^1*, Troels Wienecke^3,7*, Marie Hvelplund Kristiansen^7* and Hans C. Hasselbalch^1,3*

¹Department of Hematology, Zealand University Hospital, Roskilde, Denmark
²Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
³Faculty of Health and Medical Sciences, Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
⁴Department of Production, Research, and Innovation, Region Zealand, Soroe, Denmark
⁵Department of Laboratory Medicine, Boston Children's Hospital, Boston, MA
⁶Department of Pathology, Harvard Medical School, Boston
⁷Department of Neurology, Zealand University Hospital, Roskilde, Denmark

Naseema Gangat, MBBS¹, Giuseppe Gaetano Loscocco^2*, Patricia Carey, MD^3*, Priyansh Faldu^4*, Moazah Iftikhar, MBBS^5*, Masooma S Rana, MBBS^5*, Yamna Jadoon, MBBS⁶, Animesh D. Pardanani, MBBS, PhD⁵, Natasha Szuber, MD, MSc⁷, Alessandra Carobbio^8*, Tiziano Barbui, MD^9*, Alessandro Maria Vannucchi¹⁰, Ayalew Tefferi, MD¹ and Paola Guglielmelli, MD¹¹

¹Division of Hematology, Mayo Clinic, Rochester, MN
²Department of Experimental and Clinical Medicine, CRIMM, Center of Research and Innovation of Myeloproliferative Neoplasms, Azienda Ospedaliero-Universitaria Careggi, University of Florence, Florence, Italy
³Mayo Clinic, Rochester, MN
⁴Mayo Clinic, Rochester
⁵Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN
⁶UMass Chan Medical School Baystate, Broad Brook, CT
⁷Institut universitaire d'hématologie-oncologie et de thérapie cellulaire, Université de Montréal, Montreal, QC, Canada
⁸Fondazione per la Ricerca Ospedale di Bergamo (FROM), Bergamo, Italy
⁹FROM Research Foundation ASST Papa Giovanni XXIII Bergamo, Bergamo, ITA
¹⁰Department of Experimental and Clinical Medicine, Centro di Ricerca e Innovazione Malattie Mieloproliferative (CRIMM), AOU Careggi, University of Florence, Firenze, Tuscany, Italy
¹¹Department of Experimental and Clinical Medicine, Centro di Ricerca e Innovazione Malattie Mieloproliferative (CRIMM), AOU Careggi, University of Florence, Florence, Italy

Adam J Mead, PhD, MRCP, FRCPath¹, Brian J P Huntly, MD^2*, Bethan Psaila, MD, PhD³, Claire Harrison⁴, Rebecca Boucher^5*, Jiayi Wang^5*, Rebecca Collings^5*, Zsofia Nagy^5* and Rebecca Record^5*

¹Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford, United Kingdom
²Department of Haematology and Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
³Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford, ENG, United Kingdom
⁴Guy's and St Thomas' NHS Foundation Trust, London, ENG, United Kingdom
⁵University of Birmingham, Birmingham, United Kingdom

Francesca Palandri, MD, PhD^1*, Venediktos Kapetanakis^2*, Balazs Dobi^3*, Filippo Branzanti, MSc^4*, Catherine Ellis, BS^5*, Nick Ballew, PhD^5*, Tom Liu, MS^5*, Kelesitse Phiri, ScD^5*, Fulya Sen Nikitas^6*, Melania Biasi^7*, Shiyuan Zhang, MSc^5* and Dwaipayan Patnaik, MD, MBBS⁸

¹IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico S. Orsola-Malpighi, Istituto di Ematologia "Seràgnoli", Bologna, Italy
²Evidera Ltd, London, United Kingdom
³Evidera, Budapest, Hungary
⁴IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Bologna, Italy
⁵GSK plc, Collegeville, PA
⁶GSK plc, London, United Kingdom
⁷GSK plc, Verona, Italy
⁸GSK plc, Baar, Switzerland

Orly Leiva, MD^1,2, Steven Soo, M.D.^3*, Nathaniel Smilowitz^4*, Harmony Reynolds^4*, Binita Shah^4*, Samuel Bernard^4*, Michelle Hyunju Lee, MD⁵, Chi-Joan How, MD⁶ and Gabriela S. Hobbs, MD⁷

¹University of Chicago, New York City, NY
²New York University Langone Health, New York City, NY
³New York University Long Island School of Medicine, Mineola, NY
⁴New York University Grossman School of Medicine, New York City, NY
⁵Department of Medical Oncology, Massachusetts General Hospital, Winchester, MA
⁶Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA
⁷Division of Hematology/Oncology, Massachusetts General Hospital, Boston, MA

Arnon Haran^1*, Avital Wasserstrom^2*, Shlomzion Aumann^3*, Vladimir Vainstein, MD^4*, Romi Kazoom^2*, Batia Roth Jelinek, MD^4*, Ariela Arad, MD^5*, Noa Buchman, MD^4*, Ela Shai, PhD^4*, Yossi Kalish, MD^5*, Moshe E Gatt, MD⁶ and Eran Zimran^7*

¹Department of Hematology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
²Hadassah Hebrew University Medical Center, Jerusalem, Israel
³Department of Hematology, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel
⁴Department of Hematology, Hadassah Medical Center, Jerusalem, Israel
⁵Hematology Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
⁶Hematology department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
⁷Hadassah Medical Center, Jerusalem, Israel

Ghaith Abu-Zeinah, MD, Katie Erdos^*, Neville Lee Jr.^*, Richard T. Silver, MD and Joseph M. Scandura, MD, PhD

Richard T. Silver, MD Myeloproliferative Neoplasms Center, Weill Cornell Medicine, New York, NY

Francesca Palandri, MD, PhD^1*, Marta Sobas, MD^2*, Claire Harrison³, Raajit Rampal, MD, PhD⁴, Sarah Buckley, MD^5*, Purvi Suthar, PharmD^5*, Karisse Roman-Torres^5* and John O. Mascarenhas, MD⁶

¹IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia s. Orsola-Malpighi, Bologna, Italy
²Wroclaw Medical University, Wroclaw, Poland
³Guys and St Thomas NHS Trust, London, United Kingdom
⁴Memorial Sloan Kettering Cancer Center, New York, NY
⁵Sobi Inc., Waltham, MA
⁶Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY