Ali Al-Mousawi, MD^1,2,3*, Stine Ulrik Mikkelsen, MD, PhD^1,2,3*, Amalie Bach Nielsen, MD^2*, Anders Pommer Vallentin, MD^1,2*, Astrid Ø. Mortensen^1,2*, Zachary Madaj^3*, Jakob Jespersen^2*, Linn Gillberg, PhD, MSc^1,2*, Jakob Werner Hansen, MD, PhD^1,2*, Mette Klarskov Andersen, MD, PhD^4*, Bo Mortensen, MD^1,5*, Marianne Tang Severinsen, MD, PhD^6*, Casey O'Connell, MD^7*, Jens Lykkesfeldt, Professor PhD, DMSc^8*, Peter A. Jones, PhD, DSc^3* and Kirsten Gronbaek, MD, PhD, PR^1,3,9

¹Dept. of Hematology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
²Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark
³Department of Epigenetics, Van Andel Institute, Grand Rapids, MI
⁴Department of Clinical Genetics, Centre of Diagnostic Investigations, Copenhagen University Hospital, Copenhagen, Denmark
⁵Herlev University Hospital, Herlev, Denmark
⁶Aalborg University Hospital, Aalborg, Denmark
⁷USC Norris Cancer Center, Los Angeles, CA
⁸Life Science Faculty, University of Copenhagen, Copenhagen, Denmark
⁹Rigshospitalet, University of Copenhagen, Copenhagen N, Denmark

Huafeng Wang^1*, Xudong Wei, MD, PhD^2*, Yang Liang³, Jianyu Weng, MD, PhD^4*, Wenjuan He^5*, Chunkang Chang, MD, PhD^6*, Suning Chen, MD, PhD^7*, Hongbing Ma^8*, Zi Chen, MD, PhD^9*, Lichuang Men, MSc^9*, Lihui Liu, MD, PhD^9*, Xiaohong Tian, MD^9*, Zhang Zhang, MD, PhD^10*, Danhua Cong, MS^9*, Dajun Yang, MD, PhD^10,11*, Yifan Zhai, MD, PhD^10,12 and Jie Jin, MD, PhD^13*

¹The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
²Henan Cancer Hospital, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China
³Sun Yat-sen University Cancer Center, Guangzhou, China
⁴Guangdong Provincial People's Hospital, Guangdong, China
⁵Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⁶Shanghai Sixth People’s Hospital, Shanghai, China
⁷The first Affiliated Hospital of Soochow University, Suzhou, China
⁸West China Hospital, Sichuan University, Chengdu, China
⁹Ascentage Pharma (Suzhou) Co., Ltd., Suzhou, China
¹⁰Ascentage Pharma Group Inc., Rockville, MD
¹¹Department of Experimental Research, State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China
¹²State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China
¹³The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

Rurika Okuda, MSc, BS^1,2*, Yotaro Ochi, MD, phd^1*, Tetsuichi Yoshizato, MD, PhD¹, Yasuhito Nannya^1*, Yoshiko Atsuta^3*, Yuichi Shiraishi^4*, Yusuke Shiozawa, MD^1,5*, Hiroko Tanaka^6*, Makoto Onizuka⁷, Kenichi Chiba^4*, Hidehiro Itonaga, MD, PhD⁸, Yoshinobu Kanda, MD, PhD^9*, Yasushi Miyazaki, MD, PhD⁸, Keizo Horibe, MD, PhD^10*, Satoru Miyano, PhD^6*, Hideki Makishima, MD, PhD¹ and Seishi Ogawa, MD, PhD^2,11

¹Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
²Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan
³The Japanese Data Center for Hematopoietic Cell Transplantation, Nagakute, Japan
⁴Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
⁵Department of Pediatrics, The University of Tokyo, Tokyo, Japan
⁶M&D Data Science Center, Tokyo Medical and Dental University, Tokyo, Japan
⁷Department of Hematology/Oncology, Tokai University, Isehara, Japan
⁸Japan Adult Leukemia Study Group, and Department of Hematology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan
⁹Division of Hematology, Jichi Medical University, Tochigi, Japan
¹⁰Clinical Research Center, NHO Nagoya Medical Center, Nagoya, Japan
¹¹Kyoto University, Sakyoku, KYO, Japan

Guillermo Montalban-Bravo, MD¹, Kelly S. Chien, MD¹, Sanam Loghavi, MD², Rashmi Kanagal-Shamanna, MD³, Anuya A. Natu, MBBS^4*, Mark Gurney, MB, BCh, BAO^4*, Alexandre Bazinet, MD^5*, Danielle Hammond, MD¹, Gautam Borthakur, MD⁶, Mahesh Swaminathan, MD^1*, Courtney D. DiNardo, MD, MSc¹, Tapan M. Kadia, MD¹, Farhad Ravandi, MBBS⁷, Naval Daver, MD⁸, Naveen Pemmaraju, MD⁹, Ghayas C. Issa, MD¹, Terra L. Lasho, PhD¹⁰, Christy Finke, BS^4*, Aref Al-Kali, MD⁴, Clifford M. Csizmar, MD, PhD¹¹, Hassan B Alkhateeb, MD^4*, Naseema Gangat, MBBS⁴, Abhishek A. Mangaonkar, MBBS¹⁰, Ayalew Tefferi, MD⁴, Hagop Kantarjian, MD¹, Guillermo Garcia-Manero, MD¹ and Mrinal M. Patnaik, MD, MBBS¹⁰

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Hematopathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX
⁴Division of Hematology, Mayo Clinic, Rochester, MN
⁵Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston
⁶Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁷Department of Leukemia, University of Texas- MD Anderson Cancer Center, Houston, TX
⁸MD Anderson Cancer Center, Houston, TX
⁹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Bellaire, TX
¹⁰Mayo Clinic, Rochester, MN
¹¹Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN

Laura Palomo, PhD^1*, Mireia Morgades^2*, Manja Meggendorfer, PhD³, Marina Díaz-Beyá, MD, PhD^4*, Helena Pomares^5*, Guillermo Ramil López, MD^6*, Mariam Ibañez^7*, Mar Tormo, MD⁸, Felix Lopez, MD^9*, Alejandro Avendaño Pita^10*, Juan Carlos Caballero^11*, Jordi Vila Bou^12*, Juan Restrepo^13*, Veronica Roldan^14*, Pilar Galán^15*, Estefania Cerezo Velasco, MD^16*, Cristina Notario^17*, ANA Garcia Feria^18*, Torsten Haferlach, MD¹⁹, Sandra Castaño-Díez, MD^4*, Esther Alonso^20*, Marta Pratcorona, MD, PhD^6*, Rosa Collado^21*, Marisa Calabuig^22*, Pamela Acha^23*, Gerardo Aguilar-Monserrate^11*, Marta Cabezón^2*, Neus Ruiz Xiville, PhD^2*, Maria Diez-Campelo, MD, PhD^24*, Lurdes Zamora, PhD^25* and Blanca Xicoy, MD^26*

¹ICO-Hospital Germans Trias i Pujol, Institut de Recerca contra la Leucèmia Josep Carreras (IJC), Universitat Autònoma de Barcelona, Badalona, ESP
²ICO-Hospital Germans Trias i Pujol, Institut de Recerca contra la Leucèmia Josep Carreras (IJC), Universitat Autònoma de Barcelona, Badalona, Spain
³MLL Munich Leukemia Laboratory, Munich, Bavaria, Germany
⁴Hematology Department, Hospital Clínic de Barcelona, Barcelona, Spain
⁵Clinical Hematology Department, ICO-Hospitalet, Hospital Durán i Reynals. IDIBELL, Barcelona., Barcelona, Spain
⁶Hematology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
⁷Hospital General Universitario de Valencia, Valencia, ESP
⁸Department of Hematology and Medical Oncology,, Hospital Clínico Universitario de Valencia. INCLIVA Biomedical Research Institute, Valencia, Spain
⁹Experimental Hematology, Hospital Universitario Vall d’Hebrón, Institut d’Oncologia Vall d’Hebrón (VHIO), Barcelona, ESP
¹⁰Hospital Universitario de Salamanca, Instituto de Investigacion Biomedica de Salamanca (IBSAL), Centro de Investigación del Cancer (IBMCC-USAL, CSIC), Salamanca, Spain
¹¹Hospital Clínico Universitario de Valladolid, Valladolid, Spain
¹²Institut Català d’Oncologia - Hospital Universitari de Girona Dr. Josep Trueta, Girona, ESP
¹³Institut Català d’Oncologia - Hospital Universitari de Tarragona Joan XXIII, Tarragona, Spain
¹⁴Hospital Universitario Cruces, Bilbao, Spain
¹⁵Complejo Asistencial de Segovia, Segovia, ESP
¹⁶Hematology Department, Consorcio Sanitario de Terrassa, Terrassa, Spain
¹⁷Hospital Universitario Nuestra Señora de la Candelaria, Santa Cruz de Tenerife, Spain
¹⁸Hospital Universitario Doctor Peset, Valencia, Spain
¹⁹MLL Munich Leukemia Laboratory, Munich, Germany
²⁰Hospital De Bellvitge, L'Hospitalet De Llobregat, Ba, ESP
²¹Hospital Clínico Universitario de Valencia, Instituto de Investigación Sanitaria INCLIVA, Valencia, ESP
²²Hospital Clínico Universitario de Valencia, Valencia, Spain
²³Experimental Hematology, Hospital Universitario Vall d’Hebrón, Institut d’Oncologia Vall d’Hebrón (VHIO), Barcelona, Spain
²⁴Hospital Clínico Universitario de Salamanca, Salamanca, Spain
²⁵Haematology Department, ICO-Hospital Germans Trias i Pujol, Institut de Recerca contra la Leucèmia Josep Carreras (IJC), Universitat Autònoma de Barcelona, Badalona, Spain
²⁶Hematology Service, ICO-Hospital Germans Trias i Pujol, Institut de Recerca contra la Leucèmia Josep Carreras (IJC), Universitat Autònoma de Barcelona, Badalona, Spain

Guru Subramanian Guru Murthy, MBBS¹, Somedeb Ball, MD², Jonathan Feld, MD³, Ramzi Abboud⁴, Michael Haddadin, MBBS⁵, Shyam Ajay Patel, MD, PhD⁶, Ashwin Kishtagari, MBBS⁷, Hayley Hawkins^8*, Veronica Guerra, MD^9*, Emily Dworkin, PharmD^10*, Reema K. Tawfiq, MD¹¹, Dominika Dulak, MD¹², Amber Feng, MD^13*, Christina Cotte^14*, Adam Cohen-Nowak^15*, Asmita Shukla, MD¹⁶, Suresh Kumar Balasubramanian, MD¹⁷, Eric S. Winer, MD¹⁸, Charles Foucar, MD¹⁹, Yasmin Abaza, MD¹⁵, Rory M. Shallis, MD²⁰, Chenyu Lin, MD²¹, Talha Badar, MD²², Anand Ashwin Patel, MD²³, Annie Im, MD²⁴, Aniko Szabo, PhD^1* and Ehab L. Atallah, MD²⁵

¹Medical College of Wisconsin, Milwaukee, WI
²Vanderbilt University Medical Center, Vanderbilt-Ingram Cancer Center, Nashville, TN
³Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
⁴Washington University School of Medicine, Clayton, MO
⁵Fred & Pamela Buffet Cancer Center, University of Nebraska Medical Center, Omaha, NE
⁶UMass Chan Medical School, Worcester, MA
⁷Department of Medicine, Division of Hematology and Oncology, Vanderbilt University Medical Center, Franklin, TN
⁸Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN
⁹Washington University St Louis, St Louis
¹⁰Department of Pharmacy, University of Chicago, Chicago, IL
¹¹Division of Hematology and Medical Oncology, Mayo Clinic, Jacksonville, FL
¹²Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA
¹³Duke University Hospital, Durham, NC
¹⁴Yale University, New Haven, CT
¹⁵Northwestern University, Chicago, IL
¹⁶Department of Oncology, Karmanos Cancer Institute/Wayne State University, Detroit, MI
¹⁷Department of Oncology, Karmanos Cancer Institute/Wayne State University, Troy, MI
¹⁸Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
¹⁹University of New Mexico, Ann Arbor, MI
²⁰Department of Internal Medicine, Section of Hematology, Yale School of Medicine - Yale Cancer Center, Killingworth, CT
²¹Duke University Cancer Institute, Durham, NC
²²Department of Hematology/Oncology, Mayo Clinic, Jacksonville, FL
²³Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL
²⁴UPMC Hillman Cancer Center, Univ. of Pittsburgh Cancer Institute, Pittsburgh, PA
²⁵Division of Hematology/Oncology, Medical College of Wisconsin, Milwaukee, WI

Katharina S. S. Götze, MD^1,2,3, Anna Hecht, MD^4*, Anne Sophie Kubasch, MD⁵, Maria Diez-Campelo, MD, PhD^6*, Georg Stüssi, MD^7*, David Valcarcel, MD, PhD⁸, Patricia Font Lopez, MD^9*, Elvira Mora Castera, MD^10*, Blanca Xicoy, MD^11*, Teresa Bernal Del Castillo, MD, PhD^12*, Dominik Wolf, M.D.^13*, Nicola Andina, MD, PhD^14*, Nicolas Bonadies, MD¹⁵, Gregor Stehle, MD^16*, Karoline V. Gleixner, MD^17*, Klaus H Metzeler, MD⁵, Arnold Schröder^18*, Dorothea Schipp^18*, Maria Tormo, MD^19*, Ana Alfonso Pierola, MD, PhD^20*, Aristoteles Giagounidis, MD²¹, Martin Puttrich^18* and Uwe Platzbecker, MD⁵

¹Department of Medicine III, Hematology and Oncology, Technical University of Munich (TUM) School of Medicine and Health, Munich, Bavaria, Germany
²German Cancer Consortium (DKTK), partner site Munich, Heidelberg, Germany
³Bavarian Center for Cancer Research (BZKF), Munich, Germany
⁴Department of Medicine III, Hematology and Oncology, Technical University of Munich (TUM) School of Medicine and Health, Munich, Germany
⁵Department of Hematology, Cellular Therapy, Hemostaseology and Infectious Diseases, University Leipzig Medical Center, Leipzig, Germany
⁶Hospital Clínico Universitario de Salamanca, Salamanca, Spain
⁷Oncology Institute of Southern Switzerland (IOSI), Ente Ospedaliero Cantonale, Bellinzona, Switzerland
⁸Department of Hematology and Oncology, Hospital Universitario Vall d'Hebron, Barcelona, Spain
⁹Department of Hematology, Hospital General Universitario Gregorio Marañón, Madrid, Spain
¹⁰Department of Hematology, University Hospital La Fe of Valencia, VALENCIA, ESP
¹¹Department of Hematology, University Hospital Català d' Oncologia de Badalona (German University Trias y Pujol), Spain, Badalona, Spain
¹²Hospital Universitario Central de Asturias, Oviedo, Spain
¹³University Hospital of Internal Medicine V (Hematology and Oncology), Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria
¹⁴Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, Bern, Switzerland
¹⁵Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
¹⁶University Hospital Basel, Department of Hematology, Basel, Basel Stadt, CHE
¹⁷Division of Hematology & Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria
¹⁸GWT-TUD GmbH, Dresden, Germany
¹⁹Department of Hematology, University Hospital of Valencia, Valencia, Spain
²⁰University Hospital of Navarra, Pamplona, Spain
²¹Clinic for Hematology, Oncology and Palliative Care Marien Hospital Düsseldorf, Dusseldorf, Germany

Thomas Wiseman^1,2,3*, Michaela Spooner, BSc(LabMed)^3*, Shreyas Khanna^1,2,3*, Kevin Hung, MBBS, FRACP, FRCPA¹, Carla Toop, PhD^1*, Deepak Singhal, MBBS, MD, FRACP, FRCPA^2,4,5*, David M Ross, MD, PhD, FRACP, FRCPA^4,5,6*, David T Yeung, MBBS, PhD, BSc, FRACP, FRCPA^1,2,3, Anna Brown, PhD^5*, Hamish S Scott, PhD⁵, Christopher N. Hahn, PhD^5,7*, Daniel Thomas, MD, PhD^1,3,8, Chung How Kok, BSc, PhD^3* and Devendra Hiwase, MD, MBBS, PhD, FRACP, FRCPA^1,2,3

¹Royal Adelaide Hospital, Adelaide, SA, Australia
²University of Adelaide, Adelaide, SA, Australia
³South Australian Health and Medical Research Institute, Adelaide, SA, Australia
⁴South Australian Health and Medical Research Institute, Adelaide, Australia
⁵SA Pathology, Adelaide, SA, Australia
⁶Royal Adelaide Hospital and SA Pathology, Adelaide, SA, Australia
⁷University of South Australia, Adelaide, SA, Australia
⁸University of Adelaide, Stanford, CA

Julie Braish, MD^1*, Guillermo Montalban-Bravo, MD², Farhad Ravandi, MBBS³, Nicholas J. Short, MD², Tapan M. Kadia, MD², Maro Ohanian, DO^2*, Kelly S. Chien, MD⁴, Lucia Masarova, MD², Koji Sasaki, MD², Musa Yilmaz, MD^2*, Naval Daver, MD¹, Gautam Borthakur, MD⁵, Hagop M. Kantarjian, MD² and Guillermo Garcia-Manero, MD²

¹MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, University of Texas- MD Anderson Cancer Center, Houston, TX
⁴Department of Leukemia, MD Anderson, Houston, TX
⁵Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX

Mikkael A. Sekeres, MD¹, Valeria Santini^2*, Amer M. Zeidan, MBBS, MHS³, Uwe Platzbecker, MD⁴, Rami S. Komrokji, MD⁵, Maria Diez-Campelo, MD, PhD^6*, Pierre Fenaux, MD⁷, Michael R. Savona, MD^8*, Yazan F. Madanat, MD⁹, David Valcarcel, MD, PhD¹⁰, Antoine Regnault^11*, Kristin Creel, MSc^12*, Nishan Sengupta, PhD^13*, Souria Dougherty, MBA^13*, Sheetal Shah, BA^13*, Libo Sun, PhD^13*, Ying Wan, MD, PhD^13*, Shyamala Navada, MD^14* and Esther Natalie Oliva, MD¹⁵

¹Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL
²MDS Unit, Hematology, University of Florence, DMSC, AOUC, Florence, Italy
³Department of Internal Medicine, Section of Hematology, Yale School of Medicine - Yale Cancer Center, New Haven, CT
⁴Department for Hematology, Cell Therapy, Hemostaseology and Infectious Diseases, University of Leipzig Medical Center, Leipzig, Germany
⁵Moffitt Cancer Center, Tampa, FL
⁶Hospital Clínico Universitario de Salamanca, Salamanca, Spain
⁷Service d'Hématologie Séniors, Hôpital Saint-Louis, Université Paris 7, Paris, France
⁸Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN
⁹Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX
¹⁰Department of Hematology and Oncology, Hospital Universitario Vall d'Hebron, Barcelona, Spain
¹¹Modus Outcomes, a THREAD company, Lyon, France
¹²Modus Outcomes, a Division of THREAD, Lyon, France
¹³Geron Corporation, Foster City, CA
¹⁴Executive Medical Director, Geron, Foster City, CA
¹⁵Hematology Unit, Grande Ospedale Metropolitano BMM, Reggio Calabria, Reggio Calabria, Italy

Vasileios Papadopoulos^*, Dimitrios Koparanis, MSc^*, George Vrachiolias^*, Christina Misidou^*, Konstantinos Liapis, MD, PhD, Menelaos Konstantinos Papoutselis, MD^* and Ioannis Kotsianidis, PhD

Democritus University of Thrace, Department of Hematology, University Hospital of Alexandroupolis, Alexandroupolis, Greece, Alexandroupolis, Greece

Ian M. Bouligny, MD¹, Guillermo Montalban-Bravo, MD¹, Koji Sasaki, MD¹, Naval Daver, MD², Elias Jabbour, MD¹, Yesid Alvarado Valero, MD¹, Courtney D. DiNardo, MD, MSc³, Farhad Ravandi, MBBS⁴, Naveen Pemmaraju, MD⁵, Tapan M. Kadia, MD¹, Lucia Masarova, MD¹, Koichi Takahashi, MD, PhD⁶, Michael Andreeff, MD, PhD⁷, Alexandre Bazinet, MD^1*, Hui Yang, PhD, MD¹, Rashmi Kanagal-Shamanna, MD⁸, Sherry Pierce, BSN, BA^1*, Meghan Anne Meyer, BSN, RN^1*, Xuelin Huang, PhD^9* and Guillermo Garcia-Manero, MD¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX
⁴Department of Leukemia, University of Texas- MD Anderson Cancer Center, Houston, TX
⁵Department of Leukemia, The University of Texas MD Anderson Cancer Center, Bellaire, TX
⁶Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
⁷Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁸Department of Hematopathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX
⁹Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX

Mithun V Shah, M.D., Ph.D.¹, Kevin Hung, MBBS, FRACP, FRCPA², Anmol Baranwal, MBBS^1*, Zoe Price, BSc (Hons)^3*, Aref Al-Kali, MD⁴, Carla Toop, PhD^2*, Patricia Greipp, DO⁵, Anna Brown, PhD^6*, Dariusz Ladon, PhD^7*, Dong Chen, MD, PhD⁵, Kebede Begna, MD⁸, Monika Kutyna, PhD^9*, Danielle Rud^1*, Mark R. Litzow, MD¹, William J. Hogan, MD¹, Peter Bardy, MBBS^10,11*, Talha Badar, MD¹², Sharad Kumar, PhD^13*, David T Yeung, MBBS, PhD, BSc, FRACP, FRCPA^2,14,15, Mrinal M. Patnaik, MD, MBBS⁴, James M. Foran, MD¹⁶, Rong He, MD⁵, Naseema Gangat, MBBS¹, Hamish S Scott, PhD^6,13, Cecilia Y. Arana Yi, MD¹⁷, Hassan B Alkhateeb, MD^1*, Abhishek A. Mangaonkar, MBBS⁴, Daniel Thomas, MD, PhD, FRACP, FRCPA^14,18, Christopher N. Hahn, PhD^6,19*, Attilio Orazi, MD^20*, Daniel A. Arber, MD²¹, Chung Hoow Kok, PhD, BSc^22,23, Ayalew Tefferi, MD¹ and Devendra Hiwase, MD, MBBS, PhD, FRACP, FRCPA^14,15

¹Division of Hematology, Mayo Clinic, Rochester, MN
²Royal Adelaide Hospital, Adelaide, SA, Australia
³Central Adelaide Local Health Network, Adelaide, SA, Australia
⁴Mayo Clinic, Rochester, MN
⁵Division of Hematopathology, Mayo Clinic, Rochester, MN
⁶SA Pathology, Adelaide, SA, Australia
⁷Genetics and Molecular Pathology, SA Pathology, Adelaide, SA, Australia
⁸Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN
⁹Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, Australia
¹⁰Department of Haematology, Central Adelaide Local Health Network, Adelaide, SA, Australia
¹¹Haematology Department, Sa Pathology, Adelaide, Australia
¹²Division of Hematology and Oncology, Mayo Clinic, Jacksonville, FL
¹³Centre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, SA, Australia
¹⁴South Australian Health and Medical Research Institute, Adelaide, SA, Australia
¹⁵University of Adelaide, Adelaide, SA, Australia
¹⁶Division of Hematology & Medical Oncology, Mayo Clinic, Jacksonville, FL
¹⁷Division of Hematology/Oncology, Mayo Clinic, Scottsdale, AZ
¹⁸Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia
¹⁹University of South Australia, Adelaide, SA, Australia
²⁰Texas Tech University Health Sciences Center, El Paso
²¹University of Chicago, Chicago, IL
²²Centre for Cancer Biology and SA Pathology, Adelaide, Australia
²³Precision Cancer Medicine Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia

Maria Julia Montoro, MD, PhD^1*, Pamela Acha^1*, Manja Meggendorfer, PhD², Najla H Al Ali, MS^3*, Víctor Navarro^4*, Sherry Pierce, BSN, BA^5*, Carlos Bravo-Perez, MD^6*, Marie Adeline Migeon^7*, Mestre Julia^8*, Klaus H Metzeler, MD⁹, Michael Wulfert^10*, Andres Jerez, MD, PhD^1*, Marina Díaz-Beyá, MD, PhD^11*, Beate Betz^12*, Emmanuelle Clappier, Pharm.D., Ph.D.^13*, Mar Tormo, MD^14*, Helena Pomares^15*, Mónica Del Rey^16*, Silvia Saumell, MD, PhD^17*, Laura Barbero^18*, María Eugenia Rivero, MD^19*, Maria Diez-Campelo, MD, PhD^20*, David Sallman, MD²¹, Teresa Ezponda^22*, Weina Chen, MD, PhD^23*, Zhuoer Xie, MD, MS³, Francesc Bosch, MD, PhD²⁴, Ulrich Germing, MD^25*, Uwe Platzbecker, MD⁹, Francesc Sole, PhD²⁶, Pierre Fenaux, MD²⁷, Jaroslaw Maciejewski⁶, Guillermo Garcia-Manero, MD⁵, Rami S. Komrokji, MD³, Torsten Haferlach, MD²⁸ and David Valcarcel, MD, PhD²⁹

¹Department of Hematology, Vall d'Hebron University Hospital, Barcelona, Spain
²MLL Munich Leukemia Laboratory, Munich, Bavaria, Germany
³Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL
⁴Oncology Data Science (ODysSey), Vall d'Hebron Institute of Oncology (VHIO), Hospital Universitario Vall d’Hebron, Barcelona, Spain
⁵Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁶Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
⁷Interne - Service Hématologie Sénior, Hôpital Saint Louis, St Louis, France
⁸MDS Group, Institut de Recerca Contra la Leucèmia Josep Carreras, Badalona, Spain
⁹Department for Hematology, Cell Therapy, Hemostaseology and Infectious Diseases, University of Leipzig Medical Center, Leipzig, Germany
¹⁰Department of Haematology, Oncology and Immunology, Düsseldorf University Hospital, Düsseldorf, Germany
¹¹Hematology Department, Hospital Clínic de Barcelona, Barcelona, Spain
¹²Institute for Human Genetics, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
¹³Saint Louis Hospital, Paris, France
¹⁴Department of Hematology, Hospital Clínico de Valencia, Valencia, Spain
¹⁵Clinical Hematology Department, ICO-Hospitalet, Hospital Durán i Reynals. IDIBELL, Barcelona., Barcelona, Spain
¹⁶Department of Hematology, Salamanca-IBSAL University Hospital, Salamanca, Spain
¹⁷Department of Hematology, Hospital Universitari Vall d'Hebron, Barcelona, Spain
¹⁸Department of Hematology, Hospital Ramón y Cajal, Madrid, Spain
¹⁹Department of Hematology, Hospital Arnau de Vilanova, Lérida, Spain
²⁰University of Salamanca, IBSAL, IBMCC, CSIC, Cancer Research Center, Department of Hematology - Hospital Universitario de Salamanca, Salamanca, Spain
²¹Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
²²Centro de Investigación Biomédica en Red de Cáncer, CIBERONC, Madrid, Spain
²³Department of Pathology, UT Southwestern Medical Center, Dallas, TX
²⁴Hematology Department, Hospital Universitario Vall d’Hebron, Barcelona, Spain
²⁵Department of Hematology, Oncology and Clinical Immunology, University Medical Center Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany
²⁶Myelodysplastic Syndromes Research Group, Institut De Recerca Josep Carreras, Badalona, Barcelona, Spain
²⁷Service d'Hématologie Séniors, Hôpital Saint-Louis, Université Paris 7, Paris, France
²⁸MLL Munich Leukemia Laboratory, Munich, Germany
²⁹Department of Hematology, Vall d’Hebron Institute of Oncology, University Hospital Vall d’Hebron,, Barcelona, Spain

Jan Philipp Bewersdorf, MD¹, Xiaoli Mi, MD², Bin Lu^1*, Andrew T. Kuykendall, MD³, David Sallman, MD³, Manish Patel, MD^4*, Don A. Stevens, MD⁵, Alexander Philipovskiy, MD, PhD^6*, Grerk Sutamtewagul, MD⁷, Lucia Masarova, MD⁸, Gina Keiffer, MD⁹, Amit Verma, MD¹⁰, Neha Bhagwat, PhD¹¹, Diane Heiser, PhD^11*, Sunhee Ro, PhD^11*, Wan-Jen Hong¹¹, Omar Abdel-Wahab, MD¹² and Eytan M. Stein, MD¹³

¹Memorial Sloan Kettering Cancer Center, New York, NY
²Department of Medicine, Cell Therapy Service, Memorial Sloan Kettering Cancer Center, New York, NY
³Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
⁴Florida Cancer Specialists, Sarah Cannon Research Institute, Sarasota, FL
⁵Norton Cancer Institute, Louisville, KY
⁶Florida Cancer Specialists, Sarah Cannon Research Institute, Lake Mary, FL
⁷Holden Comprehensive Cancer Center, University of Iowa Healthcare, Iowa City, IA
⁸Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁹Sidney Kimmel Comprehensive Cancer Center, Thomas Jefferson University, Philadelphia, PA
¹⁰Blood Cancer Institute, Department of Oncology, Albert Einstein College of Medicine, Bronx, NY
¹¹Prelude Therapeutics Incorporated, Wilmington, DE
¹²Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
¹³Department of Medicine; Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, NY

Esther Natalie Oliva, MD¹, Uwe Platzbecker, MD², Matteo Giovanni Della Porta, MD^3*, Guillermo Garcia-Manero, MD⁴, Valeria Santini^5*, Pierre Fenaux, MD⁶, Jake Shortt^7*, Rami S. Komrokji, MD⁸, Christopher G. Pelligra^9*, Shien Guo, PhD^10*, Aylin Yucel^11*, Mrudula B. Glassberg^12*, Laurie Eliason^11*, Ahmed Hnoosh^13*, Dimana Miteva^14*, Shelo Rose¹¹, Sandra Kreitz^14*, Mikkael A. Sekeres, MD¹⁵ and Amer M. Zeidan, MBBS, MHS¹⁶

¹Hematology Unit, Grande Ospedale Metropolitano Bianchi Melacrino Morelli, Reggio Calabria, Italy
²Medical Clinic and Policlinic 1, Hematology and Cellular Therapy, University Hospital Leipzig, Leipzig, Germany
³Cancer Center IRCCS Humanitas Research Hospital, Milan, Italy and Department of Biomedical Sciences, Humanitas University, Milan, Italy
⁴Department of Leukemia, University of Texas M.D. Anderson Cancer Center, Houston, TX
⁵MDS Unit, Hematology, University of Florence, DMSC, AOUC, Florence, Italy
⁶Service d'Hématologie Séniors, Hôpital Saint-Louis, Université Paris 7, Paris, France
⁷Monash University and Monash Health, Melbourne, VIC, Australia
⁸Moffitt Cancer Center, Tampa, FL
⁹Evidera, Atlanta, GA
¹⁰Evidera, Bethesda, MD
¹¹Bristol Myers Squibb, Princeton, NJ
¹²Bristol Myers Squibb, Madison, NJ
¹³Bristol Myers Squibb, Uxbridge, United Kingdom
¹⁴Celgene International Sàrl, a Bristol-Myers Squibb Company, Boudry, Switzerland
¹⁵Division of Hematology, Sylvester Cancer Center, University of Miami, Miami, FL
¹⁶Department of Internal Medicine, Section of Hematology, Yale School of Medicine - Yale Cancer Center, New Haven, CT

Rami S. Komrokji, MD¹, Zena Komrokji^1*, Najla H. Al Ali, Ms^2*, Zhuoer Xie, MD, MS¹, Onyee Chan, MD^3*, Andrew T. Kuykendall, MD¹, Joseph E. Jabbour^4*, Alison R. Walker, MD, MBA, MPH¹, Jeffrey E Lancet, MD¹, Eric Padron, MD¹ and David Sallman, MD⁵

¹Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL
²Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
³H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
⁴Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵Moffitt Cancer Center and Research Institute, Tampa, FL

Talha Badar, MD¹, Mobachir El Kettani, MD^2*, Kashish J. Shah, MBBS^2*, Terra L. Lasho, PhD³, Yael Kusne, MD, PhD⁴, Christy M Finke^5*, James M. Foran, MD⁶, Mohamed A. Kharfan-Dabaja, MD, MBA⁷, Hemant S. Murthy, MD², Yao-Shan Fan, MD, PhD², Liuyan Jiang, MD^8*, Naseema Gangat, MBBS⁵, Abhishek A. Mangaonkar, MBBS³, Aref Al-Kali, MD^3,5,9, Ludovica Marando, MD, PhD⁹, Ayalew Tefferi, MD⁵, Rong He, MD¹⁰, David Viswanatha, MD¹¹, Mark R. Litzow, MD⁵ and Mrinal M. Patnaik, MD, MBBS³

¹Division of Hematology-Oncology, Blood and Marrow Transplantation Program, Mayo Clinic, Jacksonville, FL
²Mayo Clinic, Jacksonville, FL
³Mayo Clinic, Rochester, MN
⁴Mayo Clinic, Phoenix, AZ
⁵Division of Hematology, Mayo Clinic, Rochester, MN
⁶Division of Hematology & Medical Oncology, Mayo Clinic, Jacksonville, FL
⁷Department of Hematology/Oncology, Mayo Clinic, Jacksonville, FL
⁸Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine and Science, Jacksonville
⁹Mayo Clinic, Rochester
¹⁰Division of Hematopathology, Mayo Clinic, Rochester, MN
¹¹Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester

Ted M. Getz, MD¹, Tariq Kewan, MD², Jan Philipp Bewersdorf, MD^3,4, Jessica M. Stempel, MD², Luca Lanino, MD⁵, Wei Wei, MD, PhD⁶, Najla H. Al Ali, Ms^7*, Amy E. DeZern, MD, MHS⁸, Mikkael A. Sekeres, MD⁹, Geoffrey L. Uy, MD¹⁰, Hetty E. Carraway, MD, MBA¹¹, Pinkal Desai¹², Elizabeth A. Griffiths, MD¹³, Eytan M. Stein, MD¹⁴, Andrew M. Brunner, MD¹⁵, Christine M. McMahon, MD¹⁶, Rory M. Shallis, MD¹⁷, Joshua F. Zeidner, MD¹⁸, Michael R. Savona, MD¹⁹, Somedeb Ball, MD¹⁹, Namrata S. Chandhok, MD²⁰, Constantine Logothetis, MD²¹, Aram Bidikian, MD², Gail J. Roboz, MD²², Benjamin Rolles, MD^23,24, Eunice S. Wang, MD²⁵, Amyah C. Harris^15*, Maria L Amaya, MD, PhD²⁶, Hayley Hawkins^19*, Justin Grenet, MD, MPhil¹², Zhuoer Xie, MD, MS²⁷, Yazan F. Madanat, MD²⁸, Yasmin Abaza, MD²⁹, Talha Badar, MD³⁰, Torsten Haferlach, MD³¹, Jaroslaw Maciejewski³², David Sallman, MD⁷, Anoop K Enjeti, MBBS, FRCPA, MD, MRCP³³, Kamal Al-Rabi, MD^34*, Khalid Halahleh, M.B.S.S.^34*, Devendra Hiwase, MD, MBBS, PhD, FRACP, FRCPA³⁵, Maria Diez-Campelo, MD, PhD^36*, David Valcarcel, MD, PhD³⁷, Claudia Haferlach, MD³¹, Lisa Pleyer, MD^38*, Ioannis Kotsianidis, PhD³⁹, Vasiliki Pappa, MD, PhD⁴⁰, Valeria Santini, MD⁴¹, Angela Consagra, MD^42*, Aref Al-Kali, MD⁴³, Seishi Ogawa, MD, PhD⁴⁴, Yasuhito Nannya, MD, PhD⁴⁴, Maximilian Stahl, MD⁴⁵, Matteo Giovanni Della Porta, MD^46*, Rami S. Komrokji, MD²⁷ and Amer M. Zeidan, MBBS, MHS²

¹Department of Internal Medicine, Section of Hematology, Yale University, Jersey City, NJ
²Department of Internal Medicine, Section of Hematology, Yale University, New Haven, CT
³Department of Internal Medicine, Section of Hematology, Yale School of Medicine - Yale Cancer Center, New Haven, CT
⁴Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY
⁵IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy
⁶School of Public Health, Department of Biostatistics, Yale University, New Haven, CT
⁷Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
⁸Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore
⁹Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL
¹⁰Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO
¹¹Department of Hematology and Medical Oncology, Taussig Cancer Institute, Leukemia Program, Cleveland Clinic, Cleveland, OH
¹²Weill Cornell Medicine, New York, NY
¹³Roswell Park Comprehensive Cancer Center, Buffalo, NY
¹⁴Department of Medicine; Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, NY
¹⁵Division of Hematology/Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
¹⁶University of Colorado School of Medicine, Denver, CO
¹⁷Department of Internal Medicine, Section of Hematology, Yale School of Medicine - Yale Cancer Center, Killingworth, CT
¹⁸Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill
¹⁹Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN
²⁰Sylvester Comprehensive Cancer Center, University of Miami-Miller School of Medicine, Miami, FL
²¹Division of Oncology, Washington University School of Medicine, Saint Louis, MO
²²Department of Medicine, Division of Hematology and Oncology, Weill Cornell Medicine, New York, NY
²³Division of Hematology, Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, MA
²⁴Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
²⁵Leukemia Service, Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY
²⁶University of Colorado, Aurora, CO
²⁷Department of Malignant Hematology, H Lee Moffitt Cancer Center, Tampa, FL
²⁸Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX
²⁹Northwestern University, Chicago, IL
³⁰Division of Hematology-Oncology, Mayo Clinic, Jacksonville
³¹MLL Munich Leukemia Laboratory, Munich, Germany
³²Taussig Cancer Center, Cleveland, OH
³³Department of Haematology, Calvary Mater Hospital, Waratah, NSW, Australia
³⁴King Hussein Cancer Center, Amman, Jordan
³⁵Royal Adelaide Hospital, Adelaide, SA, Australia
³⁶Hematology Department, Institute of Biomedical Research of Salamanca, University Hospital of Salamanca, Salamanca, Spain
³⁷Department of Hematology and Oncology, Hospital Universitario Vall d'Hebron, Barcelona, Spain
³⁸3rd Medical Department with Hematology, Medical Oncology, Hemostaseology, Rheumatology and Infectiology, Oncologic Center, Salzburg, Austria
³⁹Democritus University of Thrace, Department of Hematology, University Hospital of Alexandroupolis, Alexandroupolis, Greece, Alexandroupolis, Greece
⁴⁰Hematology Division, Second Department of Internal Medicine, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece
⁴¹MDS Unit, Hematology, AOU Careggi ‐ Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
⁴²MDS Unit, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
⁴³Mayo Clinic, Rochester, MN
⁴⁴Department of Pathology and Tumor Biology, Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan
⁴⁵Dana Farber Cancer Institute, Boston, MA
⁴⁶Humanitas Clinical and Research Center, IRCCS, Rozzano, Italy

Travis L Jensen, MS^1*, Matthew D Bradley, BS^1*, Ling Zhang, MD^2*, Rafael Bejar, MD, PhD³, R. Coleman Lindsley, MD⁴, Matthew J. Walter, MD⁵ and Johannes Goll, MS^1*

¹The Emmes Company, Rockville, MD
²Hematopathology and Laboratory Medicine, Moffitt Cancer Center & Research Institute, Tampa, FL
³University of California, San Diego, La Jolla, CA
⁴Dana-Farber Cancer Institute, Boston, MA
⁵Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO

Anne Sophie Kubasch, MD¹, Katharina Zoldan, Dr.^1*, Michael Cross, Dr.^1*, Marie Schneider^1*, Jens Przybilla^2*, Dirk Hasenclever, PhD^2,3*, Klaus H Metzeler, MD¹ and Uwe Platzbecker, MD¹

¹Department of Hematology, Cellular Therapy, Hemostaseology and Infectious Diseases, University Medical Center Leipzig, Leipzig, Germany
²Clinical Trial Centre (ZKS), Leipzig, Germany
³Institute for Medical Informatics, Statistics & Epidemiology (IMISE), Leipzig, Germany

Uwe Platzbecker, MD¹, Steven W Lane, MBBS, PhD, FRCPA, FRACP², Alice Garnier, MD^3*, Thomas Cluzeau, MD, PhD⁴, Odile Rauzy, MD^5*, Katharina S. S. Götze, MD⁶, Aristoteles Giagounidis, MD⁷, Deepak Singhal, MBBS, MD, FRACP, FRCPA^8*, Aicha Kopecky, PhD^9*, Fatiha Chermat, PhD^10* and Lionel Ades, MD, PhD¹¹

¹Department for Hematology, Cell Therapy, Hemostaseology and Infectious Diseases, University of Leipzig Medical Center, Leipzig, Germany
²Cancer Program, QIMR Berghofer Medical Research Institute, Royal Brisbane and Women’s Hospital, Brisbane, QLD, Australia
³CHU Nantes Hôpital Hôtel Dieu Hématologie Clinique, Nantes, France
⁴Department for Clinical Hematology, Nice University Hospital, Nice, Provence Alpes Cote d'Azur, France
⁵Department for Internal Medicine, Toulouse University Hospital, Toulouse, France
⁶Department of Medicine III, Hematology and Oncology, Technical University of Munich School of Medicine, Munich, Germany
⁷Dept. for Oncology, Hematology and Palliative Care, Marienhospital Düsseldorf, Düsseldorf, Germany
⁸University of Adelaide, Adelaide, SA, Australia
⁹GCP-Service International, Bremen, Germany
¹⁰Groupe Francophone des Myelodysplasies, Paris, France
¹¹Hopital Saint Louis, Paris, France

Julie A.I. Thoms, PhD^1*, Feng Yan, PhD^2*, Henry R. Hampton, PhD^1*, Sarah Davidson, RN^3*, Swapna Joshi, MSc^4*, Jesslyn Saw, BSc^5*, Chowdhury H. Sarowar, PhD^4*, Xin Ying Lim, PhD^4*, Andrea C Nunez, PhD^4*, Purvi M. Kakadia, PhD^6*, Golam Sarower Bhuyan, PhD^4*, Xiaoheng Zou, MSc^1*, Mary Nguyen, BSc^1*, Elaheh S Ghodousi, MSc^1*, Forrest C Koch, BSc^7*, Fatemeh Vafaee, PhD^7*, I. Richard Thompson^8*, Mohammad M. Karimi, PhD^8*, Russell Pickford, PhD^9*, Mark J Raftery, PhD^9*, Sally Hough^10*, Griselda Buckland^3*, Michelle Bailey^10*, Yuvaraj Ghodke^3*, Noorul Absar^10*, Lachlin Vaughan, MBBS, PhD^11*, Leonardo Pasalic, MBBS, PhD^12*, Chun Yew Fong, MBBS, FRACP, FRCPA, PhD^13*, Melita Kenealy^14*, Devendra Hiwase, MD, MBBS, PhD, FRACP, FRCPA¹⁵, Rohanna Stoddart, MD^16*, Soma Mohammed^17*, Linda Lee^18*, Freda H Passam, MD, PhD¹⁹, Stephen Robert Larsen, MBBS PhD FRACP FRCPA²⁰, Kevin J Spring^21*, Kristen K Skarratt^22*, Patricia Rebeiro^23*, Peter Presgrave, MBBS²⁴, William S Stevenson, MBBS, FRACP, FRCPA, PhD^25*, Silvia Ling^26*, Campbell Tiley^27*, Stephen Fuller^22*, Fernando Roncolato^28*, Anoop K Enjeti, MBBS, FRCPA, MD, MRCP²⁹, Dirk Hoenemann, MD^30*, Charlotte Lemech^31*, Christopher J Jolly, PhD^1*, Stefan K. Bohlander, MD^6*, David J. Curtis, MBBS, PhD⁵, Jason Wong, PhD^32*, Ashwin Unnikrishnan, PhD⁴, Mark S. Hertzberg, MD³³, Jake Olivier, PhD^34*, Mark N Polizzotto^3* and John E Pimanda, MBBS, PhD, FRACP, FRCPA³⁵

¹School of Biomedical Sciences, University of New South Wales, Randwick, Australia
²Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
³ANU Clinical Hub for Interventional Research (CHOIR), John Curtin School of Medical Research, Canberra, Australia
⁴School of Clinical Medicine, University of New South Wales, Randwick, Australia
⁵Australian Centre for Blood Diseases, Monash University, Melbourne, VIC, Australia
⁶Leukaemia and Blood Cancer Research Unit, Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
⁷School of Biotechnology and Biomolecular Sciences, University of New South Wales, Randwick, Australia
⁸Comprehensive Cancer Centre, School of Cancer and Pharmaceutical Sciences, King’s College London, London, United Kingdom
⁹Bioanalytical Mass Spectrometry Facility, University of New South Wales, Randwick, Australia
¹⁰Kirby Institute, University of New South Wales, Randwick, Australia
¹¹Westmead Hospital, Sydney, Australia
¹²Westmead Hospital, Westmead, Australia
¹³Department of Hematology, Austin Health, Heidelberg, VIC, Australia
¹⁴Cabrini Hospital, Melbourne, Australia
¹⁵Royal Adelaide Hospital, Adelaide, SA, Australia
¹⁶University of New South Wales, Randwick, Australia
¹⁷ICPMR, Department of Haematology, Westmead Hospital, Westmead, Australia
¹⁸Royal North Shore Hospital, Sydney, Australia
¹⁹Haematology Research Group, Heart Research Institute, Sydney, NSW, Australia
²⁰Royal Prince Alfred Hospital, Camperdown, Australia
²¹Medical Oncology Group, Liverpool Clinical School, Western Sydney University, Liverpool, Australia
²²Sydney Medical School, Nepean Clinical School, University of Sydney, Kingswood, Australia
²³Blacktown Hospital, Blacktown, Australia
²⁴Wollongong Hospital, Wollongong, Australia
²⁵Royal North Shore Hospital, Sydney, AUS
²⁶Liverpool Hospital, Liverpool, Australia
²⁷Central Coast Health, Gosford Hospital, Gosford, Australia
²⁸St George Hospital, Kogarah, Australia
²⁹Department of Haematology, Calvary Mater Hospital, Waratah, NSW, Australia
³⁰Otway Pharmaceutical Development and Consulting Pty Ltd, Forrest, Australia
³¹Scientia Clinical Research Limited, Sydney, Australia
³²School of Biomedical Sciences, The University of Hong Kong, Hong Kong, SAR, China
³³Prince of Wales Hospital and University of New South Wales, Sydney, Australia
³⁴School of Mathematics and Statistics, University of New South Wales, Randwick, AUS
³⁵School of Biomedical Sciences, University of New South Wales, Sydney, NSW, Australia

Xin Yan Sr., MD^1*, Yulu Tian^2*, Yan Gu^2*, Chunhua Song, M.D., Ph.D.³ and Zheng Ge, MD, PhD⁴

¹Department of Hematology, Zhongda Hospital, Institute of Hematology Southeast University, School of Medicine, Southeast University, Nanjing, China
²Department of Hematology, Zhongda Hospital, Institute of Hematology Southeast University, School of Medicine, Southeast University,, Nanjing, China
³The Division of Hematology, The Ohio State University Wexner Medical Center, the James Cancer Hospital, Columbus, OH
⁴Department of Hematology, Zhongda Hospital, School of Medicine, Southeast University, Institute of Hematology Southeast University, Nanjing, China

Guillermo Garcia-Manero, MD¹, David Sallman, MD², Stefano R Tarantolo, MD³, Amit Verma, MD⁴, Stefanie Groepper, MD^5*, Alice Mims, MD⁶, Yasmin Abaza, MD⁷, James P. Dugan, MD⁸, Valle Gomez G De Soria, MD^9*, Gaurav S Choudhary, PhD^10*, Maureen Lane, PhD^10*, Wanying Zhao, PhD^10*, Ashish Jain, MS^10*, Cole Gallagher, BS^10* and Uwe Platzbecker, MD¹¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
³Nebraska Cancer Specialists, Omaha, NE
⁴Hematology/Oncology, Montefiore Medical Center/ Albert Einstein College of Medicine, Bronx, NY
⁵Marien Hospital, University of Düsseldorf, Düsseldorf, Germany
⁶Division of Hematology, The Ohio State University Comprehensive Cancer Center, Columbus, OH
⁷Northwestern Medicine, Chicago, IL
⁸Malignant Hematology and Cellular Therapy Department, Novant Health Cancer Institute - Forsyth Medical Center, Winston, Salem, NC
⁹Hospital Universitario La Princesa, Madrid, Spain
¹⁰Curis Inc., Lexington, MA
¹¹Leipzig University Hospital, Leipzig, Germany

Gabrielle T. Prince, MD^1*, Praneeth Baratam, MBBS², Guillermo Garcia-Manero, MD³, Anne Angiolillo, MD^4*, Tarun Bhagnani, MS, BPharm^4*, Assaf Vestin, PhD^4* and Amir T. Fathi, MD⁵

¹Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD
²Medical University of South Carolina/Hollings Cancer Center, Charleston, SC
³Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Servier Pharmaceuticals, Boston, MA
⁵Center for Leukemia, Massachusetts General Hospital Cancer Center, Boston, MA

Hammad Tashkandi, MD¹, Xiaohui Zhang, MD, PhD^2,3*, Rami S. Komrokji, MD⁴, Najla H. Al Ali, Ms^5*, Zhuoer Xie, MD, MS⁴, Alison R. Walker, MD, MBA, MPH⁶, Eric Padron, MD⁷, Jeffrey E Lancet, MD⁷, David Sallman, MD⁷ and Ling Zhang, MD^1*

¹Hematopathology and Laboratory Medicine, Moffitt Cancer Center & Research Institute, Tampa, FL
²Department of Pathology, H. Lee Moffitt Cancer Center, Tampa, FL
³University of South Florida College of Medicine, Tampa, FL
⁴Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL
⁵Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL
⁶Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Wesley Chapel, FL
⁷Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL

Rami S. Komrokji, MD¹, Najla H. Al Ali, Ms^2*, Zhuoer Xie, MD, MS¹, Zena Komrokji^1*, Joseph E. Jabbour^3*, Onyee Chan, MD^4*, Seongseok Yun, MD, PhD¹, Andrew T. Kuykendall, MD¹, Alison R. Walker, MD, MBA, MPH¹, Jeffrey E Lancet, MD¹, Eric Padron, MD¹ and David Sallman, MD⁵

¹Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL
²Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
³Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
⁵Moffitt Cancer Center and Research Institute, Tampa, FL

Rami S. Komrokji, MD¹, Maria Diez-Campelo, MD, PhD^2,3,4*, Lynette C.Y. Chee, MBBS, PhD, FRACP, FRCPA^5,6, Thomas Cluzeau, MD, PhD^7*, Amy E. DeZern, MD, MHS⁸, Pierre Fenaux, MD⁹, Guillermo Garcia-Manero, MD¹⁰, Aristoteles Giagounidis, MD¹¹, Uwe Platzbecker, MD¹², Matteo Giovanni Della Porta, MD^13,14*, Valeria Santini, MD^15,16, Mikkael A. Sekeres, MD¹⁷, Amer M. Zeidan, MD¹⁸, Rena Buckstein, MD, FRCPC¹⁹, Miranda Ross^20*, Ying Jiang, PhD, MBA^20*, Suresh Bobba^20*, Montagu Hankin, MSc^20*, Chris Materna, MSc^20*, Christine Graham, PhD^20*, Sanjay Thamake, PhD, MBA^20*, Christopher Rovaldi, MSc^20*, Dena Grayson, MD, PhD^20* and Jen L. Salstrom, MD, PhD²⁰

¹Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL
²Centro de Investigación Biomédica en Red de Cáncer, CIBERONC, Madrid, Spain
³Department of Hematology, Salamanca-IBSAL University Hospital, Salamanca, Spain
⁴University Hospital of Salamanca, Salamanca, Spain
⁵Department of Medicine, The University of Melbourne, Parkville, VIC, Australia
⁶ACRF Laboratory, The Royal Melbourne Hospital, Parkville, VIC, Australia
⁷Hematology Department, Nice University Hospital, Cote d’Azur University, Nice, France
⁸The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD
⁹Hopital Saint Louis, Groupe Francophone des Myelodysplasies, Paris, France, PARIS, FRA
¹⁰MD Anderson, Houston
¹¹Clinic for Hematology, Oncology and Palliative Care Marien Hospital Düsseldorf, Dusseldorf, Germany
¹²University Hospital of Leipzig, Leipzig, Germany
¹³IRCCS Humanitas Research Hospital and Humanitas University, Rozzano, Milan, Italy
¹⁴Humanitas University, Milan, Italy
¹⁵AOU Careggi, University of Florence, Firenze, Italy
¹⁶MDS Unit, AOU Careggi, DMSC, University of Florence, Firenze, Italy
¹⁷Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL
¹⁸Department of Internal Medicine, Section of Hematology, Yale University, New Haven, CT
¹⁹Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada
²⁰Kero's Therapeutics, Lexington