Farah Yassine, MD, MSc¹, Firas Saad, MD^1*, Mahija Cheekati, MD¹, John Rutledge, MAS^2*, Brian Baksa, MD^1* and Mohamad Cherry, MD, MSc¹

¹Morristown Medical Center, Morristown, NJ
²Atlantic Center for Research, Morristown Medical Center, Morristown, NJ

Ting Liu^1,2*, Xingli Zhao^3*, Xiaohui Suo^4*, Guanchen Bai^5*, Yanliang Bai, MD^6*, Weihua Zhao, MD^7*, Hongling Peng, MD^8*, Fang Zheng^9*, Dongmei Wang^10*, Liyun Zhao^11*, Jie Liu¹², Ling Li^13*, Xinxiao Lu^3*, Congcong Zhang^14*, Sifeng Gao^5*, Zeyan Shi^7*, Yunya Luo^15*, Xuemei Zhao^9*, Yaxian Tan^16*, ZePing Zhou, MD, PhD¹⁶, Pengxiang Guo^17*, Yingchang Mi, MD^2,18 and Kaiqi Liu^19*

¹State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Tianjin, China
²Tianjin Institutes of Health Science, Tianjin, China
³Department of Hematology, Oncology Center, Tianjin People's Hospital, No. 190 jieyuan Road, Hongqiao District, Tianjin 300121, P R China., Tianjin, China
⁴Department of Hematology, Handan Central Hospital, Handan, Hebei, China., Handan, China
⁵Department of Hematology, The Affiliated Tai'an City Central Hospital of Qingdao University, Taian, Shandong, China, 271000., Taian, China
⁶Department of Hematology, Zhengzhou University People's Hospital and Henan Provincial People's Hospital, Zhengzhou, China
⁷Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
⁸Department of Hematology, The Second XIANGYA Hospital, Changsha, China
⁹Department of Hematology, The Second People’s Hospital of Guiyang, Guiyang, Guizhou, China, 550081., Guiyang, China
¹⁰Department of Hematology, Harrison International peace Hospital, Hengshui, Hebei, China, 053000., Hengshui, China
¹¹Department of Hematology, People Hospital of XingTai, Xing Tai, Hebei, China, 054001, Xingtai, China
¹²Department of Hematology, Sinopharm Tongmei General Hospital, Datong, Shanxi, China, 037003, Datong, China
¹³Department of Hematology, Inner Mongolia People's Hospital, Huhehaote, Neimenggu, China, 010000, Huhehaote, China
¹⁴Department of Hematology, Handan Central Hospital, Handan, Hebei, China, 056000,, Handan, China
¹⁵Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, People's Republic of China., Changsha, China
¹⁶Department of Hematology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China, Kunming, China
¹⁷Department of Hematology, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, China, Guiyang, China
¹⁸National Clinical Research Center for Blood Diseases, State Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Tianjin, China
¹⁹State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China

Jorge E. Cortes, MD¹, Gail J. Roboz, MD², Justin M. Watts, MD³, Maria R. Baer, MD⁴, Brian A. Jonas, MD, PhD⁵, Gary J. Schiller, MD⁶, Karen Yee, MD, FRCPC^7*, P. Brent Ferrell, MD⁸, Jay Yang, MD⁹, Eunice S. Wang, MD¹⁰, William Blum, MD¹¹ and Alice Mims, MD¹²

¹Georgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA
²Weill Cornell Medicine and The New York Presbyterian Hospital in New York City, New York, NY
³Leukemia Service, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL
⁴University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD
⁵UC Davis Comprehensive Cancer Center, Davis, CA
⁶Division of Hematology and Oncology, University of California, Los Angeles, Los Angeles, CA
⁷Princess Margaret Cancer Centre / University Health Network, Toronto, ON, Canada
⁸Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN
⁹Karmanos Cancer Institute, Detroit, MI
¹⁰Roswell Park Cancer Institute, Buffalo, NY
¹¹Emory University, Winship Cancer Institute, Atlanta, GA
¹²The Ohio State University, Columbus, OH

Curtis A Lachowiez, MD¹, Adam Julian Cohen-Nowak, MD^2*, Talha Khan, PharmD^2*, Joanna Cwykiel, PhD^3*, Bukky Florence Tabiti, MD⁴, Irum Khan, MD², Shira N. Dinner, MD², Justin Grenet, MD, MPhil¹, Aya Agha, MD^5*, Jennifer N. Saultz, DO¹, Arpita Gandhi, MD¹, Gabrielle Meyers, MD^1*, Laura F. Newell, MD¹, Jessica T. Leonard, MD⁶, Brandon Hayes-Lattin, MD¹, Elie Traer, MD, PhD¹, Richard T. Maziarz, MD⁶, Rachel J. Cook, MD, MS⁵, Ronan T. Swords, MD, PhD, FRCP, FRCPath¹, Jessica Altman, MD² and Yasmin Abaza, MD²

¹Knight Cancer Institute, Oregon Health & Science University, Portland, OR
²Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL
³Division of Hematology and Oncology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL
⁴, Northwestern University, Feinberg School of Medicine, Robert H. Lurie Comprehensive Cancer Center, Chicago, IL
⁵Oregon Health & Science University, Portland, OR
⁶Knight Cancer Institute, Oregon Health and Science University, Portland, OR

Weiming Li, MD^1*, Fang Cheng^2*, Jing Zou^3*, Yuanyan Tang^4*, Haiyan Wang^5*, Jie Tan^6*, Qihuan Liu^7*, Hongbo Ren^6*, Meifang Su^8*, Hongxiang Wang^9*, Zhuangzhi Yang^10*, Lulu Zhang^11*, Renying Ge^12*, Jing He^13*, Chuancai Liu^14*, Jun Qin^15*, Jing Zheng^5* and Zhe Zhao^16*

¹Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
²Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
³Department of Hematology, Union hospital, Tongji Medical college, Huazhong University of science and Technology, Wuhan, China
⁴Department of Hematology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, China
⁵Department of Hematology, Yi Chang Central People's Hospital, The First College of Clinical Medical Science, China Three Gorges University, Yichang, China
⁶Department of Hematology, The First People's Hospital of Jingzhou, Jingzhou, China
⁷Department of Hematology, Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan, China
⁸Department of Hematology, Huanggang Central Hospital, Huanggang, China
⁹Department of Hematology, the Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
¹⁰Department of Hematology, Suizhou central hospital, Hubei Univercity of Medicine, Suizhou, China
¹¹Department of Hematology, Taihe Hospital , Hubei University of Medicine, Shiyan, China
¹²Department of Hematology, Xianning Central Hospital, Xianning, China
¹³Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430000, Wuhan, China
¹⁴Department of Hematology, Ezhou Central Hospital, Ezhou, China
¹⁵Department of Hematology, Shiyan Renmin Hospital of Hubei Medical University, Shiyan, China
¹⁶Department of Hematology, Minda Hospital of Hubei University for Nationalities, Enshi, China

Alexander E. Perl, MD¹, Mark J. Levis², Andrew Wei, MBBS, PhD^3*, Hee-je Kim, MD, PhD⁴, June-won Cheong, MD, PhD⁵, Yu Zhang, MD^6*, Jian Li, MD⁷, Hisayuki Yokoyama, MD, PhD^8*, Naoko Hosono, MD, PhD⁹, Nahla Hasabou, MD^10*, Dina Elsouda, MSc^10*, Jamie Jung-Hee An, PharmD^10* and Jianxiang Wang, MD¹¹

¹Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA
²Division of Hematologic Malignancies, Johns Hopkins University, Baltimore, MD
³Department of Hematology, The Alfred Hospital, Melbourne, Australia
⁴Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)
⁵Division of Hematology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, 03722, Korea, Republic of (South)
⁶Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China
⁷Department of Hematology, Peking Union Medical College Hospital, Beijing, China
⁸Division of Hematology and Cell Therapy, Department of Internal Medicine III, Yamagata University Graduate School of Medicine, Yamagata University, Yamagata, Japan
⁹Department of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
¹⁰Astellas Pharma Inc., Northbrook, IL
¹¹State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China

Mark J. Levis¹, Harry Erba, MD, PhD^2*, Pau Montesinos, PhD, MD^3*, Elzbieta Patkowska, MD, PhD^4*, Jorge E. Cortes, MD⁵, Herve Dombret, MD⁶, Alexander E. Perl, MD⁷, Sergio Amadori, MD⁸, Jianxiang Wang, MD⁹, Richard F. Schlenk, MD^10*, Li Liu, PhD^11*, Yasser M. Mostafa Kamel, MD, MSc, MBA¹², Karima Imadalou, MD^11*, Abderrahmane Laadem, MD^13*, Mikkael A. Sekeres, MD¹⁴ and Kristy Burns, PhD^11*

¹Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD
²Duke Cancer Institute, Durham, NC
³Hematology Department, La Fe University and Polytechnic Hospital, Valencia, Spain
⁴Department of Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland
⁵Georgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA
⁶Hôpital Saint-Louis, Hematology Department, AP-HP, Paris, Île-de-France, France
⁷Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA
⁸Tor Vergata Polyclinic Hospital Rome, Rome, ITA
⁹State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences&Peking Union Medical College, Tianjin, China
¹⁰Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany
¹¹Daiichi Sankyo, Inc., Basking Ridge, NJ
¹²Daiichi Sankyo, Basking Ridge
¹³Daiichi Sankyo, Inc, Basking Ridge
¹⁴Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL

Giovanni Marconi, MD^1,2, Alfonso Piciocchi^3*, Ernesta Audisio, MD^4*, Cristina Papayannidis, MD, PhD⁵, Fabio Guolo, MD, PhD^6,7, Marco Cerrano, MD^8*, Valentina Arena^3*, Saveria Capria, MD^9*, Michela Rondoni^10*, Matteo Giovanni Della Porta, MD^11*, Germana Beltrami, MD^12*, Monica Bocchia, MD^13*, Albana Lico^14*, Luisa Giaccone, MD, PhD^15*, Marianna Rossi, MD^16*, Catello Califano^17*, Matteo Giovanni Carrabba, MD^18*, Chiara Cattaneo, MD¹⁹, Marco Frigeni^20*, Maria Chiara Di Chio^21*, Bianca Serio, MD^22*, Roberto Freilone, MD^23*, Antonio Curti, MD, PhD⁵, Paola Minetto, MD²⁴, Giovanni Marsili^3*, Clara Minotti^25*, Beatrice Anna Zannetti^26*, Francesca Cotugno^27*, Jacopo Nanni, MD^28*, Giorgia Simonetti, Ph.D.^29*, Maria Teresa Bochicchio^30*, Sara Rosellini^31*, Elisabetta Tedone^7*, Adriano Venditti³², Roberto Massimo Lemoli, MD^33,34*, Marco Vignetti, MD^3*, Paola Fazi^3* and Giovanni Martinelli, M.D.^35,36

¹Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST S.r.l., Meldola, Italy
²Ospedale S. Maria delle Croci, university of Bologna, Bologna, Italy
³GIMEMA Foundation, Rome, Italy
⁴SC EMATOLOGIA 2, AOU CITTA DELLA SALUTE E DELLA SCIENZA, OSPEDALE S. GIOVANNI BATTISTA MOLINETTE, Torino, ITA
⁵IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Bologna, Italy
⁶Hematology Unit, Clinic of Hematology, Department of Internal Medicine (DiMI), University of Genoa, Genoa, Italy
⁷IRCCS Ospedale Policlinico San Martino, Genoa, Italy
⁸Division of Hematology, Department of Oncology, A.O.U. Città della Salute e della Scienza di Torino, Torino, To, Italy
⁹Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
¹⁰Hematology Unit & Metropolitan Transplant Network, AUSL Romagna, Ravenna, Italy
¹¹Humanitas Clinical and Research Center, IRCCS, Rozzano, Italy
¹²U.O. Ematologia e terapie cellulari, IRCCS Azienda Ospedaliera Universitaria San Martino, Genova, Italy
¹³Hematology, Azienda Ospedaliera Universitaria Senese, University of Siena, Siena, Italy
¹⁴Hematology Unit, Hematology Unit, San Bortolo Hospital, Vicenza, Italy, Vicenza, Italy
¹⁵Univesity of Torino, AOU Città Della Salute E Della Scienza Di Torino,, Torino, ITA
¹⁶Division of Hematology, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy, Pavia, ITA
¹⁷Unità Operativa Complessa di Onco-Ematologia del Plesso Ospedaliero “Andrea Tortora” di Pagani, Nocera Inferiore, ITA
¹⁸Hematology and Bone Marrow Transplantation Unit, I.R.C.C.S. San Raffaele Scientific Institute, Milan, Italy
¹⁹Hematology, ASST Spedali Civili, Brescia, Italy
²⁰Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII, Bergamo, Italy
²¹Department of Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy
²²Department of Medicine and Surgery, University of Salerno, University of Salerno, Baronissi, Salerno, Italy
²³Hematology, Department of Hematology and Oncology, Città della Salute e della Scienza di Torino, Torino, Italy
²⁴Clinic of hematology, Department of Internal medicine (DiMI), University of Genoa, Genova, Italy
²⁵Department of Translational and Precision Medicine, Division of Hematology, Sapienza University, Rome, Italy
²⁶Hematology Unit & Metropolitan Transplant Network, Ravenna and Stem Cell Transplant, AUSL Romagna, Ravenna, Italy
²⁷Fondazione Gimema, Roma, Italy
²⁸Department of Medical and Surgical Sciences - University of Bologna, Bologna, Italy
²⁹IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) “Dino Amadori", Meldola, Italy
³⁰IRCSS Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST S.r.l, Meldola, Italy
³¹Servizio di Citofluorimetria, Dipartimento di Anatomia Patologica, IRCCS Ospedale Policlinico San Martino, Genoa, Italy
³²Department of Onco-Hematology, Fondazione Policlinico Tor Vergata, Rome, Italy
³³Clinic of Hematology, Department of Internal medicine (DiMI), University of Genoa, Genoa, Italy
³⁴Clinic of Hematology, University of Genoa, IRCCS Ospedale Policlinico San Martino, Genoa, Genoa, Italy
³⁵Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy
³⁶IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola (FC), Italy

Anush Aram Ginosyan, MD^1*, Karam Ashouri, MD², Lucas Humayun^2*, Lauren Ford^2*, Mihir Baya^2*, Hee-Jung Hong^2*, Elaine Huang^2*, Brian Hom^2*, Yekta Ashtiani, MD^2*, Brandon Ann^2*, Robert Ireland, MD^2*, Shilpa Mantri, MD^2*, Sydney Greenlee^2*, Imran Siddiqi, MD, PhD^3*, Amir Ali, PharmD, BCOP⁴, Karrune Woan, MD, PhD^5*, Abdullah Ladha, MD^5*, Eric L. Tam, MD^5* and George Yaghmour, MD⁵

¹Keck School of Medicine, University of Southern California, Chatsworth, CA
²Keck School of Medicine, University of Southern California, Los Angeles, CA
³University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, CA
⁴Department of Pharmacy, University of Southern California, Norris Comprehensive Cancer Center, los angeles, CA
⁵Jane Anne Nohl Division of Hematology and Center for the study of Blood disease, Division of Hematology, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, CA

Chiara Sartor, MD^1,2*, Anna Candoni^3*, Alfonso Piciocchi^4*, Giovanni Marsili^4*, Paola Fazi^4*, Cristina Papayannidis, MD, PhD⁵, Stefania Paolini, MD, PhD^6*, Gianluca Cristiano, MD^7*, Luca Maurillo, MD^8*, Mario Tiribelli, MD^9*, Antonino Mulè, MD^10*, Melissa Campanelli^11*, Giovanni Marconi, MD^12,13, Paola Minetto, MD¹⁴, Emanuela Ottaviani, MSc^5*, Maria Teresa Voso, MD¹⁵, Francesca Bonifazi^16*, Attilio Olivieri^17*, Pellegrino Musto^18*, Francesco Di Raimondo, MD, Prof¹⁹, Roberto Massimo Lemoli, MD^20*, Maria Paola Martelli, MD, PhD^21*, Brunangelo Falini²², Michele Cavo, MD^5,23*, Adriano Venditti⁸, Francesco Buccisano, MD¹⁵ and Antonio Curti, MD, PhD⁶

¹Istituto di Ematologia “Seràgnoli”, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
²Department of Medical and Surgical Sciences - University of Bologna, Bologna, Italy
³Hematology Unit, Section of Haematology, Dept. of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Modena, Italy
⁴GIMEMA Foundation, Rome, Italy
⁵IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Bologna, Italy
⁶IRCCS Azienda Ospedaliero-Universitaria di Bologna – Institute of Hematology “Seràgnoli", Bologna, Italy
⁷Department of Medical and Surgical Sciences, Institute of Hematology "L. and A. Seràgnoli", University of Bologna, Bologna, Italy
⁸Department of Onco-Hematology, Fondazione Policlinico Tor Vergata, Rome, Italy
⁹Division of Hematology and BMT, Department of Medical Area, University of Udine, Udine, Italy
¹⁰UOC di Oncoematologia,, Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy
¹¹POLICLINICO UMBERTO I HOSPITAL, ROME, ITA
¹²Hematology Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori “Dino Amadori”, Meldola, Meldola, Italy
¹³University of Bologna, Dipartimento di Scienze Mediche e Chirurgiche, Bologna, Italy
¹⁴IRCCS Ospedale Policlinico San Martino, Genoa, Italy
¹⁵Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
¹⁶IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
¹⁷Hematology Unit, Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Ancona, Italy
¹⁸Unit of Hematology and Stem Cell Transplantation, AOUC Policlinico, Bari, Italy
¹⁹Hematology and Bone Marrow Transplatation Unit, Azienda Ospedaliero Universitaria Policlinico G. Rodolico-San Marco, Catania, Italy
²⁰Clinic of Hematology, University of Genoa, IRCCS Ospedale Policlinico San Martino, Genoa, Genoa, Italy
²¹Department of Medicine and Surgery, Division of Hematology and Clinical Immunology, University of Perugia, Perugia, Italy
²²Institute of Hematology and Center for Hemato-Oncology Research, University and Hospital of Perugia, Perugia, Italy
²³Dipartimento di Scienze Mediche e Chirurgiche (DIMEC), Università di Bologna, Bologna, Italy

Joana Brioso Infante, MD^1*, Eliana Aguiar, MD^2*, Ines Sá, MD^2*, Ines Marques, MD^2*, Miguel Neto, MD^2*, Catia Almeida, MD^3*, Telma Nascimento, MD^3*, Marta Isabel Pereira, MD³, Emilia Cortesao, MD PhD^3*, Guilherme Mendes Sapinho, MD^1*, Julia Medeiros, MD^1*, Graca Esteves, MD^1*, Tiago Monteiro-Bras, MD^4*, Luisa Regadas, MD^4*, Ines Vieira, MD^5*, Filipa Saraiva, MD^5*, Georgy Alikhanov, MD^5*, Joana Santos, MD^5*, Patricia Ribeiro, MD^5* and Fernanda Trigo, MD^2*

¹Department of Hematology and Marrow Transplantation, Centro Hospitalar Universitário Lisboa Norte – Hospital de Santa Maria, Lisboa, Portugal
²Department of Hematology, Centro Hospitalar Universitário de São João, Porto, Portugal
³Department of Hematology, Centro Hospitalar Universitário de Coimbra, Coimbra, Portugal
⁴Department of Hematology, Centro Hospitalar Universitário de Santo António, Porto, Portugal
⁵Department of Hematology, Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal

David Martinez-Cuadron, PhD¹, Rebeca Rodriguez-Veiga, MD, PhD^2*, Juan Miguel Bergua Burgues, MD^3*, Jesús Lorenzo Algarra, MD^4*, Carmen Botella^5*, Jose Antonio Pérez-Simón, MD, PhD⁶, Teresa Bernal Del Castillo, MD, PhD^7*, Mar Tormo, MD⁸, Maria Calbacho, MD^9*, Olga Salamero, MD^10*, Josefina Serrano, MD^11*, Victor Noriega Concepcion, MD^12*, Juan Antonio Lopez Lopez^13*, Susana Vives, MD^14*, Jose Luis Lopez Lorenzo, MD^15*, Mercedes Colorado, PhD^16*, Maria Vidriales Vicente^17*, Raimundo Garcia Boyero, MD^18*, Maria Teresa Olave Rubio^19*, Pilar Herrera^20*, Olga Arce, MD^21*, Manuel Barrios Garcia^22*, Maria Jose Sayas Lloris, MD^23*, Marta Polo, MD^24*, Maria Isabel Gómez Roncero, MD^25*, Eva Barragán, PhD^1*, Rosa Ayala, MD^26*, Carmen Chillon, MD^27*, Maria Jose Calasanz, PhD^28*, Bruno Paiva, PhD^28*, Blanca Boluda^1*, Ignacio Casas Aviles, M.D^3*, Pilar Lloret Madrid, MD^29*, Claudia Sargas^30*, María-José Sánchez-Sánchez^31*, Carlos Rodríguez-Medina, MD, PhD^32*, Laida Cuevas Palomares^33*, Júlia Morán Sánchez^34*, M Carmen Mateos Rodríguez^35*, Matxalen Olivares Salaverri^36*, Maria Del Carmen Martinez Chamorro^37*, Natalia Alonso Vence^38*, Sandra Suarez Ordonez, MD^39*, Irene Sanchez Vadillo^40*, María Solé-Rodríguez^41*, Bernardo Javier González González, MD^42*, Antonio Martinez Frances^43*, Rebeca Cuello^44*, Alfonso Fernández Fernández, MD^45*, Jorge Labrador, MD^46* and Pau Montesinos, PhD, MD^47*

¹Hospital Universitary i Politecnic La Fe, Valencia, Spain
²Department of Hematology, Hospital Universitari i Politècnic La Fe, Valencia, Spain
³Hospital San Pedro de Alcántara, Caceres, Spain
⁴Hospital General de Albacete, Albacete, Spain
⁵Hospital General Universitario de Alicante, Alicante, Spain
⁶Department of Hematology, Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS), CSIC, University of Sevilla, Sevilla, Spain
⁷Hospital Universitario Central de Asturias, Oviedo, Spain
⁸Department of Hematology and Medical Oncology,, Hospital Clínico Universitario de Valencia. INCLIVA Biomedical Research Institute, Valencia, Spain
⁹Hematology Department, Hospital Universitario 12 de Octubre, Madrid, Madrid, Spain
¹⁰Hematology Department, University Hospital Vall d’Hebron, Barcelona, Spain
¹¹Department of Hematology, Hospital Universitario Reina Sofía, IMIBIC.UCO, Cordoba, ESP
¹²Hospital Universitario de A Coruña, A Coruña, ESP
¹³Hospital Universitario de Jaen, Jaen, Spain
¹⁴Hematology Department, Institut Catala d'Oncologia - Hospital Germans Trias i Pujol, Badalona, Spain
¹⁵Fundacion Jimenez Diaz, Madrid, ESP
¹⁶Hospital Marqués De Valdecilla, Santander, Cantabria, ESP
¹⁷Hospital Universitario de Salamanca, Salamanca, Spain
¹⁸Hospital General Universitario de Castellon, Castellon, Spain
¹⁹Hospital Clinico Universitario Lorenzo Blesa, Zaragoza, ESP
²⁰Hospital Universitario Ramón y Cajal (IRYCIS), Madrid, Spain
²¹Hospital Universitario de Basurto, Bilbao, Spain
²²Hospital Universitario Regional de Malaga, Malaga, Spain
²³Hospital Dr. Peset, Valencia, Spain
²⁴Hospital Clínico San Carlos, MADRID, ESP
²⁵Hospital Virgen de la Salud, Toledo, Spain
²⁶Hospital Universitario 12 de Octubre, Madrid, Spain
²⁷Haematology Department, University Hospital of Salamanca, Research Biomedical Institute of Salamanca (IBSAL), CIBERONC and Center for Cancer Research-IBMCC (USAL-CSIC), Salamanca, Spain
²⁸Department of Hematology, Centre for Applied Medical Research, Cancer Center Clinica Universidad de Navarra, University of Navarra, IdiSNA, CIBERONC, Pamplona, Spain
²⁹Hospital Universitari I Politécnic La Fe, Valencia, ESP
³⁰Hospital Universitari i Politècnic La Fe, Valencia, ESP
³¹Hospital Lucus Augusti, Lugo, ESP
³²Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas, ESP
³³Hospital Universitario De Alava, Vitoria, Spain
³⁴Hospital Universitario Puerta del Mar, Cádiz, Spain
³⁵Hospital Universitario de Navarra, Pamplona, ESP
³⁶Hospital Galdakao-Usansolo Ospitalea, Bizkaia, Spain
³⁷University Hospital Quirónsalud, Pozuelo de Alarcón, Madrid, Spain
³⁸University Hospital of Santiago de Compostela, Department of Hematology, IDIS, Santiago de Compostela, Spain
³⁹Hematology Department, Complejo Hospitalario de Vigo, Vigo, Spain
⁴⁰Hospital Universitario La Paz, Madrid, ESP
⁴¹Hospital Universitario Juan Ramón Jiménez, Huelva, ESP
⁴²Hospital Universitario de Canarias, Tenerife, Spain
⁴³Hospital General Universitario Santa Lucía, Cartagena, ESP
⁴⁴Hospital Clínico Universitario de Valladolid, Valladolid, Spain
⁴⁵Hospital Universitario Virgen de la Victoria, Málaga, CA, ESP
⁴⁶Department of Hematology, Hospital Universitario de Burgos, Universidad Isabel I, Burgos, Spain
⁴⁷Hematology, Hospital Universitari I Politécnic La Fe and Programa Español de Tratamientos en Hematología (PETHEMA) Group, Valencia, Spain

Alexandre Bazinet, MD^1*, Guillermo Garcia-Manero, MD², Alex Bataller, MD, PhD^1*, Yesid Alvarado Valero, MD¹, Musa Yilmaz, MD^1*, Elias Jabbour, MD³, Guillermo Montalban-Bravo, MD¹, Naveen Pemmaraju, MD¹, Ghayas C. Issa, MD¹, Nicholas J. Short, MD¹, Tapan M. Kadia, MD¹, Nitin Jain, MD¹, Lucia Masarova, MD¹, Naval Daver, MD⁴, Danielle Hammond, MD¹, Gautam Borthakur, MD⁵, Abhishek Maiti, MBBS⁶, Koichi Takahashi, MD, PhD⁷, Kelly S. Chien, MD⁸, Steven M. Kornblau, MD¹, Hussein A. Abbas, MD, PhD¹, Maro Ohanian, DO^1*, Jayastu Senapati, MD, DM, MBBS¹, Courtney D. DiNardo, MD, MSc⁹, Hagop M. Kantarjian, MD¹ and Farhad Ravandi, MBBS¹⁰

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²MD Anderson Cancer Center, Houston
³The University of Texas MD Anderson Cancer Center, Houston, TX
⁴MD Anderson Cancer Center, Houston, TX
⁵Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁶Department of Leukemia, The University of Texas Health Science Center At Houston, Houston, TX
⁷Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
⁸Department of Leukemia, MD Anderson, Houston, TX
⁹Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX
¹⁰Department of Leukemia, University of Texas- MD Anderson Cancer Center, Houston, TX

Hawk Kim, MD, PhD¹, Jae-Sook Ahn, MD, PhD², Sung-Hyun Kim, MD^3*, Ho-Young Yhim, MD^4*, Sung-Nam Lim, MD^5*, Yoo Jin Lee, MD., PhD.⁶, Jeong-Ok Lee, MD⁷, Eun-Ji Choi, MD, PhD⁸ and Je-Hwan Lee, MD, PhD⁸

¹Division of Hematology, Ulsan University Hospital, College of Medicine, Incheon, South Korea
²Chonnam National University Hwasun Hospital, Jeollanam-Do, South Korea
³Department of Internal Medicine, Dong-A University Medical Center, Busan, Korea, Republic of (South)
⁴Chonbuk National University Hospital, Jeonju, KOR
⁵Department of Hematology-Oncology, Inje University Haeundae Paik Hospital, Busan, Korea, Republic of (South)
⁶Division of Hemato-oncology, Department of Internal Medicine, Ulsan University Hospital, Uisan, Korea, Republic of (South)
⁷Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea, Republic of (South)
⁸Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of (South)

Hongbing Ma^1*, Yiwen Du^1*, Jianjun Li^1*, Jin Rao^2*, Yong Guo^1*, Yunfan Yang^1*, Duanzhong Zhang^3*, Jia Wang^4*, Yi Liao^5* and Yuping Gong^6*

¹West China Hospital, Sichuan University, Chengdu, China
²Department of Hematology, Affiliated Hospital of Chengdu University, Chengdu, Ch, Chengdu, CHN
³Department of Hematology, Dazhou Central Hospital, Dazhou, China, Dazhou, CHN
⁴Department of Hematology, The Second People's Hospital of Neijiang, Neijiang, Ch, Neijiang, CHN
⁵Department of Hematology, West China Hospital, Sichuan University, Chengdu, China
⁶West China Hospital, Sichuan University, Chengdu, CHN

Lixian Chang, PhD^1,2*, Ju GAO^3*, Xiaoying Lei^4*, Yingyi He^5*, Shuquan Zhuang^6*, Chunhuai Li^7*, Kaizhi Weng^8*, Lingzhen Wang^9*, Xia Guo^3*, Qihui Liu^4*, Pengfei Wang^5*, Yong Zhuang^10*, Mei Yan^11*, Wei Liu^12*, Hui Chen^13*, Min Zhang^14*, Shuhong Shen¹⁵, Xiaofan Zhu, MD^1,16, Xiuli Ju^10*, Li Zhang^1,16* and Zhuo Wang^17*

¹State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, CAMS & PUMC, Tianjin, China
²Tianjin Institutes of Health Science, Tianjin, AL, China
³West China Second University Hospital, Sichuan University, Sichuan, China
⁴Children's Hospital of Chongqing Medical University, Chongqing, China
⁵Department of Pediatric Hematology/Oncology,Guangzhou Women and Children's Medical Center,Guangzhou Medical University, Guangzhou, China
⁶Department of Pediatric,Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, China
⁷Department of pediatric hematology, the First Hospital of Jilin University, Jilin, China
⁸Department of Pediatric Hematology，Rheumatology and Nephrology, Zhangzhou Municipal Hospital of Fujian Province, Zhangzhou, China
⁹the affiliated hospital of Qingdao University, Qingdao, China
¹⁰Department of Pediatrics, Qilu Hospital of Shandong University, Jinan, China
¹¹The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China
¹²Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China
¹³Tianjin Children's Hospital, Tianjin, China
¹⁴Northwest women's and children's Hospital, Xi'an, China
¹⁵Department of Hematology , Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
¹⁶Tianjin Institutes of Health Science, Tianjin, China
¹⁷Department of Hematology, Shanghai Children's Medical Center, School of Medicine,Shanghai Jiao Tong University, Shanghai, China

Kendall Diebold, CNP, MSN^1*, Todd Mudd, MD^2*, Jay Jarodiya, MD, MPH³, Katherine Parks^1*, Maris Hardee^1*, Kimo Bachiashvili⁴, Sravanti Rangaraju, MBBS⁵, Pankit Vachhani, MD^6*, Manuel Espinoza-Gutarra, MD⁷, Razan Mohty, MD⁸, Ravi Bhatia, MD⁹ and Omer Jamy, MD⁷

¹University of Alabama at Birmingham, Birmingham
²UAB, Birmingham
³UAB, Birmingham, AL
⁴O’Neal Comprehensive Cancer Center at the University of Alabama at Birmingham, Birmingham, AL
⁵University of Alabama, Birmingham, AL
⁶Division of Hematology/Oncology, O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL
⁷O'Neal Comprehensive Cancer Center at University of Alabama at Birmingham, Birmingham, AL
⁸O'Neil Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL
⁹Division of Hematology and Oncology, University of Alabama at Birmingham, Birmingham, AL

Hannah Goulart, MD¹, Hagop M. Kantarjian, MD², Naval Daver, MD¹, Musa Yilmaz, MD^2*, Guillermo Garcia-Manero, MD², Kelly S. Chien, MD³, Jan A. Burger, MD, PhD ¹, Naveen Pemmaraju, MD², Courtney D. DiNardo, MD, MSc⁴, Nicholas J. Short, MD², Guillermo Montalban-Bravo, MD², Abhishek Maiti, MBBS⁵, Danielle Hammond, MD², Ghayas C. Issa, MD², Elias Jabbour, MD², Farhad Ravandi, MBBS⁶ and Tapan M. Kadia, MD²

¹MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, MD Anderson, Houston, TX
⁴Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX
⁵Department of Leukemia, The University of Texas Health Science Center At Houston, Houston, TX
⁶Department of Leukemia, University of Texas- MD Anderson Cancer Center, Houston, TX

Xiao Han, zxiao2@126.com^1*, Hai Yi, MD^2*, Hongju Yan^3*, Ying Zhang^4*, Yun Luo^4*, Yue Xiao^5*, Mengyun Zhang^3*, Liang Fang^6*, Guo Chen^1*, Zhiyuan Peng^7*, Kai Wan^1*, Xu Tan^8*, Xiannian Qin^1*, Maihong Wang^1*, Siyu Chen^9*, Yingying Ma^1*, Hong Liu^1*, Cheng Zhang, MD, PhD^8*, Qin Wen, MD^8* and Xi Zhang, PhD¹⁰

¹Xinqiao Hospital of Army Medical University, Chongqing, China
²Department of Hematology, The General Hospital of Western Theater Command, Chengdu, China
³Xinqiao Hospital of Army Medical University, Chongqing, China
⁴The Second Affiliated Hospital of Chongqing Medical University, Chongqing, CHN
⁵The Affiliated Yongchuan Hospital of Chongqing Medical University, Chongqing, China
⁶The Ninth People's Hospital of Chongqing, Chongqing, China
⁷Affiliated Hospital of Zunyi Medical University, Zunyi, China
⁸Xinqiao Hospital, Army Medical University, Chongqing, China
⁹Medical Center of Hematology, State Key Laboratory of Trauma, Burn and Combined Injury, Xinqiao Hospital, Army Medical University, Chongqing, China
¹⁰Medical Center of Hematology, Xinqiao Hospital of Army Medical University, State Key Laboratory of Trauma and Chemical Poisoning, Chongqing Key Laboratory of Hematology and Microenvironment, Chongqing, China

Jayastu Senapati, MD, DM, MBBS¹, Farhad Ravandi, MBBS², Emmanuel Almanza, MD^1*, Tapan M. Kadia, MD¹, Guillermo Montalban-Bravo, MD¹, Stefan Faderl³, Koji Sasaki, MD¹, Nicholas J. Short, MD¹, Naval Daver, MD⁴, Courtney D. DiNardo, MD, MSc⁵, Lucia Masarova, MD¹, Alessandra Ferrajoli, MD¹, Fadi G. Haddad, MD¹, Elias Jabbour, MD⁶, Gautam Borthakur, MD⁷, Sheila Tan, RN^1*, Sherry Pierce, BSN, BA^1*, Guillermo Garcia-Manero, MD¹, Michael Andreeff, MD, PhD⁷ and Yesid Alvarado Valero, MD¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, University of Texas- MD Anderson Cancer Center, Houston, TX
³Jazz Pharmaceuticals, Palo Alto, CA
⁴MD Anderson Cancer Center, Houston, TX
⁵Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX
⁶Department of Leukemia, University of Texas M.D. Anderson Cancer Ctr., Houston, TX
⁷Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX

Georgio Medawar, MD¹, Serena Tharakan^2*, Dahniel L Sastow, MD³, Vincent Lok, BS^4*, Su Bin Hahn, BE^4*, Preston Perez, BA^4*, Abigail Demers, BS^4*, David M Swoboda, MD^5*, Douglas Tremblay^2* and Alexander Coltoff, MD¹

¹Medical University of South Carolina, Charleston, SC
²Mount Sinai Hospital, New York, NY
³Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
⁴University of South Florida Morsani College of Medicine, Tampa, FL
⁵Tampa General Hospital Cancer Institute, Tampa, FL

Thibaut Leguay, MD^1*, Laurène Fenwarth, MD, MSc^2*, Thomas Cluzeau, MD, PhD³, Anne Vekoff^4*, Etienne Lengline^5*, Juliette Lambert, MD, PhD^6*, Denis Caillot, MD^7*, Mathilde Hunault, MD, PhD^8*, Jean-Valère Malfuson, MD^9*, Sylvain Chantepie, MD^10*, Emmanuelle Tavernier, MD^11*, Berengere Gruson, MD^12*, José Fernandes, MD^13*, Pierre Peterlin^14*, Melody Fort^15*, Laure Morisset^16*, Herve Dombret, MD¹⁷, Claude Preudhomme, PharmD, PhD^18*, Arnaud Pigneux, MD, PhD^19* and Philippe Rousselot, MD PhD^20*

¹Hematology, CHU Bordeaux, BORDEAUX, France
²Hematology Laboratory, CHU Lille, Lille, France
³Department for Clinical Hematology, Nice University Hospital, Nice, France
⁴APHP-Hopital Saint Antoine, Paris, France
⁵Department of Hematology, Saint Louis University Hospital, AP-HP, PARIS, FRA
⁶Hematology, Centre Hospitalier de Versailles, Le Chesnay Rocquencourt, France
⁷Institut de cancérologie de Bourgogne clinique Drevon, dijon, France
⁸Hematology Clinic, Angers University Hospital, Angers, France
⁹Clinical Hematology Department, Percy Army Training Hospital, Clamart, France
¹⁰Basse-Normandie Institute of Hematology, CHU de Caen, Caen, France
¹¹Institut De Cancérologie De La Loire, Saint Priest En Jarez, FRA
¹²Clinique de l'Europe, Amiens, FRA
¹³Hôpital de Valenciennes, Valenciennes, France
¹⁴Hematology Department, Hôtel-Dieu University Hospital, NANTES CEDEX 1, France
¹⁵Centre Hospitalier de Versailles, Le Chesnay, France
¹⁶CENTRE HOSPITALIER DE VERSAILLES, LE CHESNAY ROCQUENCOURT, France
¹⁷Hôpital Saint-Louis, Hematology Department, AP-HP, Paris, Île-de-France, France
¹⁸Laboratory of Hematology-Molecular Biology, CHU Lille, Lille, France
¹⁹Hématologie Clinique et Thérapie cellulaire, CHU Bordeaux, Bordeaux, France
²⁰Centre Hospitalier de Versailles; Université Versailles Paris-Saclay, Versailles, France

Reeja Raj, DO¹, Samanta Catueno, MD¹, Amber Gibson, DO^1*, David McCall, MD¹, Miriam B. Garcia, DO^1*, Cesar Nunez, MD^1*, Michael E. Roth, MD¹, Koji Sasaki, MD², Priti Tewari, MD^3*, Branko Cuglievan, MD¹ and Courtney D. DiNardo, MD, MSc⁴

¹Division of Pediatrics, MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Pediatrics, Pediatric Stem Cell Transplantation and Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX

Joanna Canham^1*, Ian Thomas^1*, Nigel H. Russell, MD², Jane Leahy^3*, Abin Thomas^1*, Steve Knapper, MRCP, FRCPath, DM^4*, Lucy Marsh^1*, Huda Mohamed^1* and Sean Johnson^1*

¹Centre for Trials Research, Cardiff University, Cardiff, United Kingdom
²Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
³Private affiliation, PPI Representative, London, United Kingdom
⁴Cardiff University School of Medicine, Cardiff, United Kingdom