Kensuke Kojima, MD, PhD¹, Fumiya Ogasawara^2*, Sunggi Chi, MD^3*, Kentaro Fukushima, MD, PhD^4*, Yosuke Minami, MD, PhD³ and Tomoaki Ueda, MD, PhD^5*

¹Department of Hematology, Kochi University, Nankoku, Japan
²Kochi University, Kochi, JPN
³National Cancer Center Hospital East, Kashiwa, Japan
⁴Osaka University Graduate School of Medicine, Suita, Japan
⁵Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Japan

Sarah Aminov, PhD¹, Rongbao Zhao, PhD^1*, Kith Pradhan, PhD^2*, Srabani Sahu, MS^1*, Rahul Sanawar, PhD^1*, Shanisha Gordon Mitchell^1*, Emma Rabinovich, MD¹, Ariel Fromowitz, MD¹, Joyeeta Chakraborty, PhD^3*, Srinivas Aluri, PhD⁴, Nayem Haque, MSc^3*, Milagros Carbajal^1*, Aditi Shastri, MD¹, Ulrich Steidl⁵, Susanta Samajdar^6*, Akhil Kumar^7*, Murali Ramachandra, PhD^6*, Kristy Stengel, PhD^3*, Robert Coleman, PhD^3* and Amit Verma, MD¹

¹Blood Cancer Institute, Department of Oncology, Albert Einstein College of Medicine, Bronx, NY
²Montefiore Einstein Cancer Center, Blood Cancer Institute, Department of Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY
³Montefiore Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY
⁴Department of Oncology, Albert Einstein College of Medicine, New York, NY
⁵Department of Oncology, Montefiore Medical Center, Bronx, NY
⁶Aurigene Oncology Limited, Bangalore, IND
⁷Aurigene Oncology Lmited, Bangalore, India

Ambra Da Ros^1*, Alberto Peloso^1*, Giorgia Longo^1*, Maddalena Benetton^1*, Valentina Indio^2*, Stefano Cairo^3*, Monica Sandri^4*, Barbara Buldini, MD, PhD^1,5, Silvia Bresolin, PhD^5*, Antonio Rosato^6,7*, Andrea Pession, MD^2*, Claudia Tregnago^1*, Franco Locatelli, MD⁸ and Martina Pigazzi, PhD^1,9*

¹Department of Women's and Children's Health, Onco-hematology lab and clinic, University of Padova, Padova, Italy
²Pediatric Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, University of Bologna, Bologna, Italy
³Champions Oncology, Rockville, MD
⁴Istituto di Scienza, Tecnologia e Sostenibilità per lo Sviluppo dei Materiali Ceramici (ISSMC- CNR, Consiglio Nazionale delle Ricerche), Faenza, Italy
⁵Fondazione Istituto Ricerca Pediatrica (IRP), Padova, Italy
⁶Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Padova, Italy
⁷Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy
⁸Department of Pediatric Hematology/Oncology, Cell and Gene Therapy, IRCCS Bambino Gesù Children’s Hospital, Catholic University of the Sacred Heart, Rome, Italy
⁹Foundation Istituto Ricerca Pediatrica (IRP), Padova, Italy

Jayakumar Vadakekolathu, PhD^1*, Sarah Skuli, MD, PhD², David J Boocock, PhD^1*, Clare Coveney, PhD^1*, Eruchi G Ikpo, Mr^1*, Bofei Wang, PhD³, Elena M Fenu, MD^4*, Hussein A. Abbas, MD, PhD⁵, Catherine E. Lai, MD⁶, Martin P Carroll, MD⁶ and Sergio Rutella, MD, PhD, FRCPath¹

¹John van Geest Cancer Research Centre, Nottingham Trent University, Nottingham, United Kingdom
²University of Pennsylvania, Philadelphia, PA
³Department of Leukemia, Division of Cancer Medicine, The University of Texas At MD Anderson Cancer Cent, Houston, TX
⁴Department of Pathology, Duke University Medical Center, Durham, NC
⁵Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁶Division of Hematology/Oncology, Department of Medicine, The Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA

Hussein A. Abbas, MD, PhD¹, Bofei Wang, PhD², Jennifer Marvin-Peek, MD¹, Bin Yuan, PhD^3*, Araceli Isabella Garza^1*, Jessica Lynn Root, MS^4*, Andrea Arruda^5*, Yiwei Liu, PhD^6*, Courtney D. DiNardo, MD, MSc¹, Tapan M. Kadia, MD¹, Naval Daver, MD⁷, Philip L Lorenzi, PhD^8*, Koji Sasaki, MD¹, Steven M. Kornblau, MD¹, Mark D. Minden, MD, PhD^5*, Farhad Ravandi, MBBS⁹, Hagop M. Kantarjian, MD¹ and Patrick K. Reville, MD, MPH¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, Division of Cancer Medicine, The University of Texas At MD Anderson Cancer Cent, Houston, TX
³The University of Texas at MD Anderson Cancer center, Houston, TX
⁴Department of Leukemia, The University of Texas MD Anderson Cancer center, Houston, TX
⁵Princess Margaret Cancer Centre / University Health Network, Toronto, ON, Canada
⁶Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁷MD Anderson Cancer Center, Houston, TX
⁸The University of Texas MD Anderson Cancer Center, Houston, TX
⁹Department of Leukemia, University of Texas- MD Anderson Cancer Center, Houston, TX

Jakushin Nakahara^1*, Keita Yamamoto, MD, PhD^2*, Tomohiro Yabushita, MD PhD^3*, Takumi Chinen, PhD^3*, Kei Ito, PhD^3*, Yutaka Takeda, PhD^3*, Daiju Kitagawa, PhD^3*, Toshio Kitamura, MD, PhD^3,4 and Susumu Goyama, MD, PhD^2*

¹Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, TKY, Japan
²Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan
³Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
⁴Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation at Kobe, Kobe, Japan

Lisa D.S. Johnson^1*, Shan Tang, PhD^2*, Yajia Zhang, PhD^2*, Marlen Metzner, MSc^3*, Lisa Aviles, MBA^4*, Francois Kavelaars^5*, Eyelet Morrow, MSc^6*, Damien Vitters^5*, Kenneth Caldwell, MD⁷, Peter J. M. Valk, PhD⁸ and Paresh Vyas, FMedSci, DPhil, FRCPath^3,9,10,11*

¹Biomarker Sciences and Diagnostics, Gilead Sciences Inc., Foster City, CA
²Clinical Bioinformatics and Exploratory Analysis, Gilead Sciences Inc., Foster City, CA
³MRC Molecular Haematology Unit, Radcliffe Department of Medicine, Weatherall Institute of Medicine, University of Oxford, Oxford, United Kingdom
⁴Gilead Sciences Inc., Foster City, CA
⁵Department of Hematology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, Netherlands
⁶MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
⁷Gilead Sciences, Saint Petersburg, FL
⁸Erasmus University Medical Center, Rotterdam, Netherlands
⁹MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom
¹⁰Radcliffe Department of Medicine, Weatherall Institute of Molecular Medicine, Oxford, United Kingdom
¹¹Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom

Mengfang Xia^1,2*, Xu-Dong He, PhD^1,2*, Ruoyang Shao, MD, PhD^3*, Qifa Liu, MD³ and Qian-Fei Wang, PhD^1,2

¹China National Center for Bioinformation, Beijing, China
²Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
³Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China

Jacopo Nanni, MD^1*, Jayakumar Vadakekolathu, PhD^2*, Lorenza Bandini, MSc^3*, Marilena Ciciarello, PhD^3,4,5*, Karyna Volkava^3*, Samantha Bruno^3*, Valentina Robustelli, PhD^6*, Letizia Zannoni, MD^3*, Chiara Sartor, MD^1*, Gianluca Cristiano, MD^1*, Federico Zingarelli, MD^3*, Andrea Davide Romagnoli^3*, Caterina Azzimondi^3*, Federica Ardizzoia^3*, Raffaele Ciruolo, MD^1*, Giovanni Marconi, MD⁷, Claudia Venturi, MSc^8*, Ajsi Kanapari^3*, Gaia Mazzocchetti^1*, Giorgia Simonetti, Ph.D.^9*, Martina Ghetti, MSc^10*, Nicoletta Testoni, BSc^3*, Sarah Parisi, MD, PhD^11*, Stefania Paolini, MD^11*, Simona Soverini, PhD¹², Emanuela Ottaviani, MSc^13*, Cristina Papayannidis, MD, PhD¹³, Michele Cavo, MD^3,11*, Sergio Rutella, MD, PhD, FRCPath² and Antonio Curti, MD, PhD¹³

¹Department of Medical and Surgical Sciences - University of Bologna, Bologna, Italy
²John van Geest Cancer Research Centre, Nottingham Trent University, Nottingham, United Kingdom
³Department of Medical and Surgical Sciences, Institute of Hematology "L. and A. Seràgnoli", University of Bologna, Bologna, Italy
⁴IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
⁵Consiglio Nazionale della Richerche (CNR), Bologna, Italy
⁶IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “L.A. Seràgnoli”, Bologna, ITA
⁷Hematology Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori “Dino Amadori”, Meldola, Meldola, Italy
⁸Istituto di Ematologia “Seràgnoli”, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
⁹IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) “Dino Amadori", Meldola, Italy
¹⁰IRCSS Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST S.r.l, Meldola, Italy
¹¹IRCCS Azienda Ospedaliero-Universitaria di Bologna, Hematology Institute “L. e A. Seràgnoli”, Bologna, Italy
¹²Department of Medical and Surgical Sciences, Institute of Hematology "L. and A. Seràgnoli", University of Bologna, Castel Maggiore, Bologna, Italy
¹³IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Bologna, Italy

Jan-Niklas Eckardt^1,2*, Ishan Srivastava, MSc^3,4*, Yeqiao Xu, BSc^4*, Kellen B Gil, MD, MPH⁵, Andrea A. Osypuk, BS^6*, Zenggang Pan, MD, PhD^7*, Martin M. K. Schneider, MD^4*, Freya Schulze, MD^2*, Karsten Wendt, PhD^8*, Susann Winter, PhD^2*, Martin Bornhäuser, MD^4,9,10*, Daniel A. Pollyea, MD^11* and Jan Moritz Middeke, MD^3,4*

¹Else Kroener Fresenius Center for Digital Health, TUD Dresden University of Technology, Dresden, Germany
²Department of Internal Medicine I, University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany
³Else Kroener Fresenius Center for Digital Health, Technical University Dresden, Dresden, Germany
⁴Department of Internal Medicine I, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany
⁵Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO
⁶Pathology Shared Resource, Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO
⁷Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO
⁸Chair of Software Technology, Technical University Dresden, Dresden, Germany
⁹German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), Heidelberg, Germany
¹⁰National Center for Tumor Diseases Dresden (NCT/UCC), Technical University Dresden, Dresden, Germany
¹¹Division of Hematology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO

Xiaorong Gu, PhD^1*, Yahan Zhang, MS², Songa Bae^1*, Dongxu Jiang, PhD², Nakisha D Williams, MBBS^1*, Daniel Vail, PhD^2*, Simon Schlanger, MS^2*, Jill Durkin^2*, Yvonne Parker, MS^1*, Daniel Lindner, MD, PhD^1*, Jaroslaw Maciejewski¹ and Babal K. Jha, PhD^1,2

¹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
²Center for Immunotherapy & Precision Immuno-Oncology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH

Nicholas L.J. Chornenki, MD, BSc¹, Afraa Mustafa Sulieman Fadul^2*, Analiza Supan, CHIM^3*, Yasser Abou Mourad, MD, FRCPC, FACP^4,5, Hannah Cherniawsky, MD, MSc, BSc^3,5*, Shanee Chung, FRACP, FRCPA, FRCPC, MBChB^4,5, Donna L. Forrest, MD, FRCPC^4,5, Deepesh Pravinkumar Lad, MD, DM^1,6, Aly Karsan, MD, FRCPC^7,8, Florian Kuchenbauer, MD, PhD, FRCPC^4,5, Eric McGinnis, MD, FRCPC^8,9, Stephen H. Nantel, MD, FRCPC^4,5, Sujaatha Narayanan, MBBS, MRCP, MRCPath^4,5*, Thomas J. Nevill, MD, FRCPC^4,5, Judith Anula Rodrigo, MD, FRCPC^4,5*, Claudie Roy, MD, FRCPC^10,11*, David Sanford, MD, FRCPC^4,5, Kevin Song, MD^4,5, Cynthia L. Toze, MD, MSc, FRCPC^4,5, Jennifer White, MD, MSc, FRCPC^4,12* and Ryan J Stubbins, MD, MSc, FRCPC^4,5

¹Division of Hematology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada
²Department of Hematology and Bone Marrow Transplant, National Center for Cancer Care and Research, Hamad medical corporation, Doha, QAT
³Leukemia/Bone Marrow Transplant Program of British Columbia, British Columbia Cancer Agency, Vancouver, BC, Canada
⁴Leukemia/Bone Marrow Transplant Program of British Columbia, British Columbia Cancer Agency, Vancouver, Canada
⁵Division of Hematology, Department of Medicine, University of British Columbia, Vancouver, Canada
⁶Leukemia/Bone Marrow Transplant Program of British Columbia, BC Cancer Agency, Vancouver, BC, Canada
⁷Canada’s Michael Smith Genome Sciences Centre, BC Cancer Research Centre, Vancouver, BC, Canada
⁸Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada
⁹Department of Pathology and Laboratory Medicine, Vancouver General Hospital, Vancouver, BC, Canada
¹⁰Division of Hematology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, CAN
¹¹Department of Medicine, Division of Hematology, University of British Columbia, Leukemia Bone Marrow Transplant Program of British Columbia and Vancouver General Hospital, Vancouver, BC, Canada, Vancouver, BC, Canada
¹²The University of British Columbia, Vancouver General Hospital, Vancouver, BC, Canada

Luca Guarnera, MD^1*, Carmelo Gurnari, MD, PhD², Carlos Bravo-Perez, MD^3*, Arda Durmaz, PhD^4*, Nakisha D Williams, MBBS^1*, Hussein Awada¹, Matteo D'Addona^5*, Naomi Kawashima, MD PhD^6*, Arooj Ahmed, MD^1*, Serhan Unlu, MD⁷, Olisaemeka Ogbue, MBBS⁸, Christopher Haddad, BS^9*, Aashray Mandala, BS^1*, Yasuo Kubota, MD, PhD^1*, Juraj Bodo, PhD^2*, Genevieve M Crane, MD, PhD^10*, Heesun J. Rogers, MD^11*, Jaroslaw Maciejewski¹² and Valeria Visconte, PhD¹³

¹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
²Cleveland Clinic Foundation, Cleveland, OH
³Department of Hematology and Medical Oncology, Hospital Universitario Morales Meseguer, University of Murcia, IMIB-Pascual Parrilla, CIBERER - Instituto de Salud Carlos III, Murcia, Spain
⁴Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, CLEVELAND, OH
⁵Hematology and Transplant Center, University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, Ercolano, Italy
⁶Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
⁷Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
⁸Fairview Hospital, Cleveland Clinic Foundation, Rocky River, OH
⁹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Westlake, OH
¹⁰Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland Hts, OH
¹¹Diagnostics Institute, Robert J. Tomsich Department of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, OH
¹²Taussig Cancer Center, Cleveland, OH
¹³Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Taussig Cancer Institute, Cleveland, OH

Darren Lee, BS, MS^1,2, Yazan Abu-Shihab, MD^3,4*, Deedra Nicolet, MS^5*, Krzysztof Mrózek, MD, PhD⁵, Mark Routbort, MD, PhD^6*, Keyur P. Patel, MD, PhD^7*, Christopher J. Walker, PhD⁸, Jill Buss, BS⁸, Andrew Stiff, MD, PhD⁹, Andrea Laganson, BS^8*, Courtney D. DiNardo, MD, MSc¹⁰, Naval Daver, MD¹¹, Gautam Borthakur, MD¹², Tapan M. Kadia, MD¹³, Farhad Ravandi, MBBS¹⁴, Andrew J. Carroll, PhD¹⁵, Jonathan E Kolitz, MD¹⁶, Bayard L Powell, MD¹⁷, William Blum, MD¹⁸, Maria R. Baer, MD¹⁹, Guido Marcucci²⁰, Geoffrey L. Uy, MD²¹, Wendy Stock, MD²², Richard M. Stone, MD²³, L. Jeffrey Medeiros, MD⁷, Jeffrey W. Tyner, PhD²⁴, Robert L. Bowman, PhD²⁵, John C. Byrd, MD²⁶, James S. Blachly, MD²⁷, Sanam Loghavi, MD^7,28, Ann-Kathrin Eisfeld, MD^5,27,29 and Linde A. Miles, PhD^1,30

¹Division of Experimental Hematology and Cancer Biology, Cancer & Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
²Equal contribution, Cincinnati, OH
³The Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University Comprehensive Cancer Center, Columbus, OH
⁴Equal contribution, Columbus, OH
⁵The Ohio State University Comprehensive Cancer Center, Columbus, OH
⁶Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁷Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁸Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University Comprehensive Cancer Center, Columbus, OH
⁹Depatment of Internal Medicine, Division of Hematology, Ohio State University, Columbus, OH
¹⁰Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX
¹¹MD Anderson Cancer Center, Houston, TX
¹²Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
¹³Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
¹⁴Department of Leukemia, University of Texas- MD Anderson Cancer Center, Houston, TX
¹⁵Department of Genetics, University of Alabama at Birmingham, Birmingham, AL
¹⁶Department of Medicine, Northwell Health, Manhasset, NY
¹⁷Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, NC
¹⁸Emory University, Winship Cancer Institute, Atlanta, GA
¹⁹University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD
²⁰Department of Hematological Malignancies Translational Science, Gehr Family Center for Leukemia Research, City of Hope Medical Center and Beckman Research Institute, Duarte, CA
²¹Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO
²²Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL
²³Dana-Farber Cancer Institute, Boston, MA
²⁴Knight Cancer Institute, Oregon Health & Science University, Portland, OR
²⁵Department of Cancer Biology, University of Pennsylvania School of Medicine, Philadelphia, PA
²⁶Department of Internal Medicine, University of Cincinnati, Cincinnati, OH
²⁷The Ohio State University, Columbus, OH
²⁸Equal contribution, Houston, TX
²⁹Equal contribution, Equal Contribution
³⁰Equal contribution, Cinicinnati, OH

Salma B. Abdelbaky, BSc^1*, Matthew R Avenarius, PhD^2*, Yi Seok Chang^3*, Susan Long^2*, Kyoko Yamaguchi, BSc^4*, Yue-Zhong Wu^2*, Cecelia Miller, PhD^5,6, Ann-Kathrin Eisfeld, MD^2,7,8,9, James S. Blachly, MD^2,8,10,11, Dan Jones, MD^12,13,14 and Christopher C. Oakes, PhD^15,16,17,18

¹Division of Hematology, The Ohio State University, Columbus, OH
²The Ohio State University, Columbus, OH
³James - James Molecular Lab, The Ohio State University, Columbus, OH
⁴Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH
⁵Division of Pathology, The Ohio State University, Columbus, OH
⁶Department of Pathology, The Ohio State University Comprehensive Cancer Center, Columbus, OH
⁷The Ohio State University Comprehensive Cancer Center, Columbus, OH
⁸Division of Hematology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH
⁹Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH
¹⁰Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University Comprehensive Cancer Center, Columbus, OH
¹¹Department of Hematology, The Ohio State University Comprehensive Cancer Center, Columbus, OH
¹²Quest Diagnostics, Columbus, OH
¹³The Ohio State University Comprehensive Cancer Center, The Ohio state University, Columbus, OH
¹⁴Department of Pathology, The Ohio State University, Columbus, OH
¹⁵Division of Hematology, Department of Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, OH
¹⁶Comprehensive Cancer Center, The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH
¹⁷Department of Biomedical Informatics, The Ohio State University, Columbus, OH
¹⁸Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University Comprehensive Cancer Center, Columbus

Lacey Scott Williams, MD¹, Anne S. S. Renteria, MD², Maher Albitar, MD^3* and Gustavo A. Rivero, MD^4*

¹University of North Carolina, Alexandria, VA
²Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC
³Genomic Testing Cooperative, Lake Forest, CA
⁴Lombardi Comprehensive Cancer Center, MedStar Georgetown University Hospital, Washington, DC

Suraj Bansal^1*, David Chen, BS¹, Amanda Mitchell, PhD^1*, Andy G.X. Zeng, BSc^1,2 and John E. Dick, PhD^1,2

¹Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
²Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada

Logan K. Wallace, MSc^1*, Jack H. Peplinski, MSc^2*, Rhonda E. Ries, MA^2*, Danielle C. Kirkey, MD^2,3,4 and Soheil Meshinchi, MD, PhD^2,3

¹Translational Sciences and Threapeutics, Fred Hutchinson Cancer Center, Seattle, WA
²Translational Science and Therapeutics, Fred Hutchinson Cancer Center, Seattle, WA
³Department of Pediatrics, University of Washington, Seattle, WA
⁴Pediatric Hematology/Oncology, Seattle Children's Hospital, Seattle, WA

Brian Chernak, MD^1,2, Amy Song^3*, Benjamin May^4* and Aaron D. Viny, MD, MS⁴

¹Division of Hematology/Oncology, Columbia University Irving Medical Center, New York City, NY
²Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
³Department of Internal Medicine, Columbia University Irving Medical Center, Princeton, NJ
⁴Division of Hematology/Oncology, Columbia University Irving Medical Center, New York, NY

Wenbing Liu^1*, Yu Liu^1*, Anli Lai^1*, Runxia Gu, MD^1*, Ying Wang^1*, Qing Rao^1*, Yingchang Mi, MD², Hui Wei, MD^3*, Shaowei Qiu, MD^1*, Min Wang^1* and Jianxiang Wang, MD⁴

¹State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
²State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China, Tianjin, China
³State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences&Peking Union Medical College, Tianjin, China
⁴State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China

Alfredo Marchetti^1,2*, Francesca Lazzaroni, PhD^3*, Matteo Claudio Da Vià, MD^3*, Alessio Marella^2*, Antonio Matera^2*, Akihiro Maeda, PhD^3*, Nicolo Rampi, MD^3*, Claudia Leoni, MD^2,3*, Federico Mazzon, MD^2,3*, Elena Tagliaferri, MD^3*, Mariarita Sciumè, MD^3*, Marta Lionetti, PhD^2*, Bruno Fattizzo, MD^2,3, Francesco Passamonti, MD^2,3*, Nicola Stefano Fracchiolla, MD^3* and Niccolò Bolli, MD, PhD^2,3*

¹Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy
²Department of Oncology and Hemato-Oncology, University of Milan, Milano, Italy
³Hematology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy

Hidenori Kasahara, MD^1,2*, Takafumi Yokota, MD, PhD³, Jun Nakayama^4*, Henyun Shi^2*, Yusuke Imagawa, PhD^4*, Toru Hiratsuka^4*, Keiko Takano^4*, Yasuhiro Shingai, MD^2* and Shigeki Higashiyama,, PhD^5*

¹Hematology, Osaka University, Tokyo, Japan
²Hematology, Osaka International Cancer Institute, Osaka, Japan
³Department of Hematology, Osaka International Cancer Institute, Osaka, Japan
⁴Department of Oncogenesis and Growth Regulation, Osaka International Cancer Institute, Osaka, Japan
⁵Osaka International Cancer Institute, Osaka, Japan

Minoru Kanaya, MD, PhD^1*, Yuji Mukai, PhD^2*, Mirei Kobayashi, MD^1*, Sayaka Kajikawa, M.D., Ph.D.^1,3*, Toma Suzuki, M.D.^1*, Emi Yokoyama, M.D., Ph.D.^1*, Koh Izumiyama, M.D., Ph.D.^1*, Makoto Saito, M.D., Ph.D.^1*, Masanobu Morioka, M.D., Ph.D.^1*, Akio Mori, M.D., Ph.D.¹, Toshihiro Matsukawa, M.D., Ph.D.^4*, Masahiro Onozawa, MD⁵, Goichi Yoshimoto, MD, PhD^6*, Mitsuru Moriyama, M.D., Ph.D.^7*, Sunggi Chi, MD^8*, Takanori Teshima, MD, PhD⁹, Yosuke Minami, MD, PhD⁸, Masato Honmma, PhD^2,10* and Takeshi Kondo, M.D., Ph.D.¹

¹Blood Disorders Center, Aiiku Hospital, Sapporo, Japan
²Department of Pharmacy, University of Tsukuba Hospital, Tsukuba, Japan
³Department of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan
⁴Department of Hematology, Hokkaido University Hospital, Sapporo, Japan
⁵Department of Hematology, Hokkaido University Hospital, Sapporo, HOK, Japan
⁶Department of Hematology, Saga-Ken Medical Center Koseikan, Saga, Japan
⁷Tokyo Medical University, Tokyo, JPN
⁸National Cancer Center Hospital East, Kashiwa, Japan
⁹Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan
¹⁰Department of Pharmaceutical Sciences, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan

Shadma Shahin, MD^1*, Aarti Ramesh Achrekar, MSc^1*, Priyanka Rajesh Ugale, MSc^1*, Swapnali Joshi, MSc^1*, Vishram Terse, PhD, MSc^1*, Dhanlaxmi Lalit Shetty, PhD, MSc^2*, Nishant Jindal, MD, MBBS^3,4*, Prashant Tembhare, MD^1,4*, Sumeet Mirgh, MD, DM^3,4*, Alok Shetty, MD, DM^5*, Anant Gokarn, MD, DM^4,6*, Sachin Punatar, MD, DM^4,6*, Lingaraj Nayak, MBBS, MD, DM^4,5*, Hasmukh Jain, MD, DM^7*, Manju Sengar, MD, DM⁷, Navin Khattry, MD, DM^3,4*, Bhausaheb Bagal, MD, DM^4,6*, Sweta Rajpal, MD, DM^1,4*, Gaurav Chatterjee, MD, MSc^1,4*, PG Subramanian, MD^1*, Sumeet Gujral, MD^8* and Nikhil Patkar, MD^1,4*

¹Department of Hematopathology, ACTREC, Tata Memorial Centre, Navi Mumbai, India
²Cancer Cytogenetics, ACTREC, Tata Memorial Centre, Navi Mumbai, India
³Department of Medical Oncology, ACTREC, Tata Memorial Centre, Navi Mumbai, India
⁴Homi Bhabha National Institute, Mumbai, India
⁵Department of Medical Oncology, Tata Memorial Centre, Mumbai, India
⁶Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, India
⁷Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India
⁸Department of Pathology, Tata Memorial Centre, Mumbai, India

Lusha Cao, PhD, MS^1*, Yang Xu, PhD^2,3*, Tina Glisovic-Aplenc, PhD⁴, Han R Fisher, MS^4*, Saamia Farooki, BS⁴, Kelly D. Getz, PhD^4,5*, Todd A. Alonzo, PhD^6,7*, Alan S Gamis, MD, MPH⁸, Soheil Meshinchi, MD, PhD^9,10, Yi Xing, PhD^1,2,3* and Richard Aplenc^4,5

¹Department of Biomedical and Health Informatics, The Children's Hospital of Philadelphia, Philadelphia, PA
²Center for Computational and Genomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA
³Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA
⁴Division of Oncology, Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, PA
⁵Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
⁶Division of Biostatistics, University of Southern California, Monrovia, CA
⁷Children's Oncology Group, Monrovia, CA
⁸Hematology/Oncology/BMT, Children's Mercy Kansas City, Kansas City, MO
⁹Translational Science and Therapeutics, Fred Hutchinson Cancer Center, Seattle, WA
¹⁰Department of Pediatrics, University of Washington, Seattle, WA

Saioa Arza-Apalategi^1*, Daan Gilissen^2*, Anne van der Grinten, M.Sc.^3*, Heuts Branco^4*, Erik Van Den Akker^5*, Marieke Griffioen, PhD^6*, Joop H. Jansen, PhD^7*, Joost H.A. Martens^8* and Bert A. Van der Reijden, PhD¹

¹RadboudUMC, Nijmegen, Netherlands, Nijmegen, Netherlands
²Radboudumc, Nijmegen, NLD
³Dept Lab Medicine, Radboudumc, Nijmegen, Netherlands, Nijmegen, Netherlands
⁴radboud university, nijmegen, netherlands, nijmegen, Netherlands
⁵Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands
⁶Hematology, Leiden University Medical Center, Leiden, Netherlands
⁷Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Nijmegen, Netherlands
⁸Faculty of Science, Department of Molecular Biology, Radboud University, Nijmegen, Netherlands

Jan-Niklas Eckardt^1,2*, Marius Bill, MD, PhD^3,4,5,6*, Konstanze Döhner, MD⁷, Christian Rausch, MD^8*, Klaus H Metzeler, MD⁹, Karsten Spiekermann, MD^10,11*, Sebastian Stasik, PhD^12*, Tim Sauer, MD¹³, Sebastian Scholl, MD^14*, Andreas Hochhaus, MD¹⁵, Martina Crysandt, MD^16*, Tim H. H. Brummendorf, MD¹⁷, Utz Krug, MD^18*, Bernhard Wörmann, MD^19*, Hermann Einsele, MD²⁰, Wolfgang Hiddemann, MD^11,21*, Dennis Görlich, PhD²², Maria Cristina Sauerland, MD^22*, Björn Steffen, MD^23*, Andreas Neubauer, MD²⁴, Andreas Burchert, MD²⁵, Kerstin Schaefer-Eckart, MD²⁶, Wolfgang E. Berdel, MD²⁷, Christoph Schliemann, MD^28*, Stefan W. Krause, MD^29*, Mathias Hänel, MD³⁰, Maher Hanoun, MD, PhD^31*, Martin Kaufmann, MD³², Lars Fransecky, MD^33*, Jan Braess, MD^34*, Johannes Schetelig, MD, MSc³⁵, Jan Moritz Middeke, MD^1,2*, Lars Bullinger^36,37, Michael Heuser, MD³⁸, Felicitas R Thol, MD³⁸, Hubert Serve, MD^39,40, Claudia D Baldus, MD^41*, Uwe Platzbecker, MD⁹, Carsten Mueller-Tidow, MD^42*, Barbora Weinbergerova, MD^43*, Jiri Mayer, MD⁴⁴, Pierre-Yves Dumas, MD, PhD^45*, Sarah Bertoli, MD^46*, Eric Delabesse, MD, PhD^47*, Christian Récher, MD, PhD⁴⁸, Arnaud Pigneux, MD, PhD^49*, Tobias Herold, MD^10,11, Arnold Ganser, MD³⁸, Hartmut Döhner, MD⁵⁰, Martin Bornhäuser, MD^5,12,51*, Christian Thiede, MD¹² and Christoph Röllig, MD, MSc^52*

¹Else Kroener Fresenius Center for Digital Health, TUD Dresden University of Technology, Dresden, Germany
²Department of Internal Medicine I, University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany
³Department of Internal Medicine 1, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany
⁴Mildred Scheel Early Career Center, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany
⁵National Center for Tumor Diseases Dresden (NCT/UCC), Technical University Dresden, Dresden, Germany
⁶German Cancer Consortium (DKTK), Partner Site Dresden, Dresden, Germany
⁷Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany
⁸Laboratory for Leukemia Diagnostics, Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany
⁹Department for Hematology, Cell Therapy, Hemostaseology and Infectious Diseases, University of Leipzig Medical Center, Leipzig, Germany
¹⁰Department of Medicine III, University Hospital, LMU Munich, Munich, Germany
¹¹German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany
¹²Department of Internal Medicine I, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany
¹³Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany
¹⁴Klinik für Innere Medizin II, Jena University Hospital, Jena, Germany
¹⁵Klinik für Innere Medizin II, Abt. Hämatologie und lnternistische Onkologie, Universitätsklinikum Jena, Jena, Germany
¹⁶Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Aachen, Germany
¹⁷Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Faculty of Medicine, University Hospital RWTH Aachen, Aachen, Germany
¹⁸Department of Medicine III, Hospital Leverkusen, Leverkusen, DEU
¹⁹Department of Hematology, Oncology and Tumor Immunology, Charité Berlin, Berlin, Germany
²⁰Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany
²¹Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany
²²Institute of Biostatistics and Clinical Research, University of Münster, Muenster, Germany
²³Goethe-University Frankfurt, University Hospital, Department of Medicine II - Hematology and Oncology, Frankfurt am Main, Germany
²⁴Department of Hematology, Oncology and Immunology, Phillips-University Marburg, Marburg, Germany, Marburg, Germany
²⁵Department of Hematology, Oncology and Immunology, University Hospital Marburg, Marburg, Germany
²⁶Department of Internal Medicine V, Paracelsus Medizinische Privatuniversität and University Hospital Nuernberg, Nuernberg, Germany
²⁷Department of Medicine A (Hematology, Hemostaseology, Oncology, Pneumology), University Hospital Muenster, Muenster, Germany
²⁸Department of Medicine A, University Hospital Muenster, Muenster, Germany
²⁹Universitätsklinikum Erlangen, Erlangen, Germany
³⁰Department of Internal Medicine III, Klinikum Chemnitz, Chemnitz, Germany
³¹Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany
³²Department of Hematology, Oncology and Palliative Care, Robert Bosch Hospital, Stuttgart, Germany
³³Department of Internal Medicine II (Hematology/Oncology), University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany
³⁴Hospital Barmherzige Brueder Regensburg, Regensburg, Germany
³⁵Department of Internal Medicine I, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
³⁶German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany
³⁷Department of Hematology, Oncology, Tumor Immunology, Charité University Medicine, Berlin, Germany
³⁸Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
³⁹Department of Medicine, Hematology/Oncology, Goethe-University Frankfurt, University Hospital, Frankfurt am Main, Germany
⁴⁰German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Frankfurt, Germany
⁴¹University Medical Center Schleswig-Holstein, University Cancer Center Schleswig-Holstein, Kiel, Germany
⁴²Department of Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany
⁴³FN Brno, Brno, CZE
⁴⁴Internal Medicine Hematology and Oncology, University Hospital Brno and Masaryk University, Brno, Czech Republic
⁴⁵Hôpital Haut-Lévèque, Hematology Department, CHU Bordeaux, Pessac, France
⁴⁶IUCT-Oncopole, Hematology Department, CHU de Toulouse - Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France
⁴⁷IUCT-Oncopole, Hematology Laboratory, CHU de Toulouse - Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France
⁴⁸Hematology Department, CHU deToulouse - Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France
⁴⁹Department of Clinical Hematology, Haut-Lévèque Hospital, CHU Bordeaux, Pessac, France
⁵⁰Department of Internal Medicine III, University Hospital Ulm, Ulm, Germany
⁵¹German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), Heidelberg, Germany
⁵²Department of Internal Medicine I, University Hospital Dresden, Dresden, Germany

Xingcheng Yang^1*, Juan Peng^1*, Lei Zhang^2,3*, Yicheng Zhang^1*, Xia Mao^1*, Jue Wang^1* and Jia Wei^1,4,5

¹Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
²Medical Research Center, Key Laboratory of Digital Technology in Medical Diagnostics of Zhejiang Province, Hangzhou, China, Hangzhou, China
³Gusu School, Nanjing Medical University, Nanjing, China, Nanjing, China
⁴Sino-German Joint Oncological Research Laboratory, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Wuhan, China
⁵Department of Hematology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, China

Valentina Fabiola Ilenia Sangiorgio^1*, Rocco Piazza, MD, PhD^1*, Monica Fumagalli, MD^2*, Carlo Gambacorti-Passerini, MD, Prof.^2,3, Mariarita Sciumè, MD^4* and Daniele Ramazzotti, PhD^1*

¹Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy
²Hematology Division and Bone Marrow Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy
³Department of Medicine and Surgery, University Milano-Bicocca, Monza, Italy
⁴Hematology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy

Cristiana O'Brien^1,2, Nirvana Nursimulu, PhD^1*, Rachel Culp-Hill, PhD^3*, Julie A Reisz Haines, PhD^3*, Andrea Arruda^4*, Mark D. Minden, MD, PhD^4*, Angelo D'Alessandro, PhD³, Sushant Kumar, PhD^1*, Kristin J. Hope, PhD^1,2 and Courtney Jones, PhD^2,5

¹University Health Network, Princess Margaret Cancer Centre, Toronto, ON, Canada
²Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
³Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO
⁴Princess Margaret Cancer Centre / University Health Network, Toronto, ON, Canada
⁵Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH

Lu-Lu Wang^1*, Yu-Xiu Chen^1*, Mengtong Zang, MS^1*, Jian-Ying Zhou^1*, Meng-Yu Xiao^1*, Hai-Xia Fu, MD^1*, Xiao-Dong Mo, MD^1*, Feng-Rong Wang, MD^1*, Wei Han, MD^1*, Yuan-Yuan Zhang, MD^1*, Chen-Hua Yan, MD^1*, Zhi-Dong Wang, MD^1*, Ting-Ting Han, MD^1*, Meng Lv, MD, PhD², Huan Chen, MD^1*, Yu-Hong Chen, MD^1*, Yao Chen, MD^1*, Jing-Zhi Wang, MD^1*, Yu Wang, MD, PhD^1*, Lan-Ping Xu, MD, PhD^1*, Kai-Yan Liu, MD, PhD¹, Xiao-Jun Huang, MD, PhD¹ and Xiao-Hui Zhang, MD, PhD¹

¹Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China
²Peking University People's Hospital, Beijing, China

Y. Emily Chu, BS^1,2, Matthew A Cottam, PhD^3*, Chad R Potts, BS^1*, Kirsten M Dickerson, PhD^1*, Matthew T Jenkins, BS⁴, Justin A Cartailler, BA^1*, Rui Lu, PhD^5,6, Stanley C. Lee, PhD⁷, Ross L Levine, MD⁸, Robert L. Bowman, PhD⁹, Robert Welner, PhD¹⁰ and Brent Ferrell Jr., MD¹¹

¹Department of Medicine, Vanderbilt University Medical Center, Nashville, TN
²Medical Scientist Training Program, Vanderbilt University, Nashville, TN
³Department of Surgical Sciences, Vanderbilt University Medical Center, Nashville, TN
⁴Department of Pharmacology, Vanderbilt University, Nashville, TN
⁵O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL
⁶Department of Medicine, Division of Hematology/Oncology, University of Alabama At Birmingham, Birmingham, AL
⁷Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA
⁸Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY
⁹Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
¹⁰Division of Hematology and Oncology, Department of Medicine, UAB Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL
¹¹Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN

Gao Yuang^1,2*, Qianyu Zhang^1*, Zhichun Lv^3*, Shuhong Liu^1*, Yide Sun^1*, Huiying Gao^3*, Xiongwei Zhao^3*, Xin Li^1*, Yang Xue^3*, Hao Li^3*, Changyan Li^3* and Hongmei Ning^1*

¹Senior Department of Hematology, the Fifth Medical Center, Chinese PLA General Hospital, Beijing, China
²Graduate School, Chinese PLA General Hospital, Beijing, China
³Beijing Institute of Radiation Medicine, Beijing, China

Stephen Ting, MBBS, FRACP, FRCPA, PhD¹, Kieran Fleming^2*, Pooranee Morgan^3*, Natasha S. Anstee, PhD^4,5*, Andrew H Wei, MBBS, PhD, FRACP, FRCPA^5,6, Peter Meikle, PhD^3* and Andrew Murphy, PhD^3*

¹Department of Haematology, Eastern Health and Monash University, Elwood, VIC, Australia
²Eastern Health, Box Hill Hospital & Monash University, Box Hill, VIC, Australia
³Baker Heart and Diabetes Institute, Melbourne, VIC, Australia
⁴Department of Medical Biology, The University of Melbourne, Melbourne, Australia
⁵The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia
⁶Peter MacCallum Cancer Centre, Melbourne, VIC, Australia

Eduardo Sabino De Camargo Magalhaes, MD, PhD^1*, Brandon D. Brown, MD^2*, Yihua Qiu, MD^3* and Steven M. Kornblau, MD³

¹Department of Ageing Biology/ERIBA, University Medical Center Groningen, Groningen, Netherlands
²Department of Pediatrics, MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX

Hussein Awada¹, Carmelo Gurnari, MD, PhD^2,3, Yasuo Kubota, MD, PhD^1*, Carlos Bravo-Perez, MD^1*, Luca Guarnera, MD^1*, Matteo D'Addona^4*, Zachary Brady^1*, Mark Orland, MD¹, Serhan Unlu, MD¹, Arda Durmaz, PhD^5*, Hetty E. Carraway, MD, MBA⁶, Hassan Awada, MD^7*, Jaroslaw Maciejewski⁸ and Valeria Visconte, PhD⁸

¹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
²Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
³Cleveland Clinic Foundation, Cleveland, OH
⁴Department of Translational Hematology & Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
⁵Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, CLEVELAND, OH
⁶Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
⁷Roswell Park Comprehensive Cancer Center, Buffalo
⁸Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH

Fang Chen^1*, Dandan Zhao^1*, Yongfang Xu^1*, Huafeng Wang^1,2*, Shawn Sharkas^1*, Le Xuan Truong Nguyen^1*, Lucy Y. Ghoda^1*, Mark Boldin^3*, Guido Marcucci¹ and Bin Zhang¹

¹Department of Hematological Malignancies Translational Science, Gehr Family Center for Leukemia Research, City of Hope Medical Center and Beckman Research Institute, Duarte, CA
²Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
³Department of Systems Biology, Beckman Research Institute of City of Hope, Duarte, CA

Philip A Haddad, MD¹, Shiva Jashwanth Gaddam, MD² and Ankita Gupta, MD^3*

¹Feist-Weiller Cancer Center, LSUHSC-S/Overton Brooks VAMC, Shreveport, LA
²Department of Hematology and Oncology and Feist Weiller Cancer Center, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA
³LSUHSC-S/Overton Brooks VAMC, Shreveport

Saamia Farooki, BS¹, Han R Fisher, MS^2*, Anand S Bhagwat, MD, PhD^3,4, Tina Glisovic-Aplenc, PhD², Lusha Cao, PhD, MS^5*, Regina M. Myers, MD³, Haley Newman, MD³, Caroline Diorio, MD^6,7, Saar Gill, MD, PhD⁸ and Richard Aplenc^9,10

¹Division Of Oncology/Center For Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, PA
²Division of Oncology, Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, PA
³Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA
⁴Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA
⁵Department of Biomedical and Health Informatics, The Children's Hospital of Philadelphia, Philadelphia, PA
⁶Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
⁷Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA
⁸University of Pennsylvania, Philadelphia, PA
⁹University of Pennsylvania School of Medicine, Philadelphia, PA
¹⁰Children's Hospital of Philadelphia, Philadelphia, PA

Rebecca P. Bystrom, MD^1,2, Jan Philipp Bewersdorf, MD^3,4, Yiwen Liu, MS^5*, Eva Johanna Schaefer, MD^2*, Rory M. Shallis, MD⁶, Leora Boussi, MD⁴, Andrius Zucenka, MD⁷, Sylvain Garciaz, MD^8*, Luis E. Aguirre, MD², Daniel J. DeAngelo, MD, PhD², Richard M. Stone, MD², Marlise R. Luskin, MD², Jacqueline S. Garcia, MD², Eric S. Winer, MD², Evan C. Chen, MD², Martha Wadleigh, MD², Kelly Ling, PA-C^2*, Eytan M. Stein, MD⁹, Aaron D. Goldberg⁴, Amer M. Zeidan, MD¹⁰, Shai Shimony, MD² and Maximilian Stahl, MD²

¹NHLBI / NCI, National Institutes of Health, Bethesda, MD
²Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
³Department of Internal Medicine, Section of Hematology, Yale School of Medicine - Yale Cancer Center, New Haven, CT
⁴Department of Medicine; Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY
⁵Data Science, Dana-Farber Cancer Institute, Boston, MA
⁶Department of Internal Medicine, Section of Hematology, Yale School of Medicine - Yale Cancer Center, Killingworth, CT
⁷Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania
⁸Institut Paoli-Calmettes, MARSEILLE, France
⁹Department of Medicine; Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, NY
¹⁰Department of Internal Medicine, Section of Hematology, Yale University, New Haven, CT