Jonatan Källström^1,2*, Riitta Niinimäki, PhD^3,4*, Johan Fredlund, MD^5*, Hartmut Vogt, PhD^6,7*, Laura Korhonen, PhD^8,9*, Anders Castor, PhD^10*, Kjeld Schmiegelow, MD, DMsc^11,12, Maria Thastrup, PhD^13*, Jonas Abrahamsson, MD, PhD, Professor^2,14* and Torben Ek, PhD^2,15*

¹Children´s Cancer Centre, Queen Silvia Children´S Hospital, Gothenburg, Sweden
²Department of Pediatrics, Institute for Clinical Sciences, University of Gothenburg, Gothenburg, Sweden
³Department of Pediatrics and Adolescent Medicine, Oulu University Hospital, Oulu, Finland
⁴Research Unit of Clinical Medicine, University of Oulu, Oulu, Finland
⁵Department of Pediatrics, Halmstad County Hospital, Halmstad, Sweden
⁶Crown Princess Victoria Children’s Hospital, Linköping, Sweden
⁷Department of Biomedical and Clinical Sciences, Division of Children's and Women's Health, Linköping University, Linköping, Sweden
⁸Department of Pediatrics, University of Turku, Turku, Finland
⁹Department of Pediatrics and Adolescent Medicine, Turku University Hospital, Turku, Finland
¹⁰Department of Pediatrics, Skåne University Hospital, Lund University, Lund, Sweden
¹¹Department of Pediatrics and Adolescent Medicine, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark
¹²Medical Faculty, Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
¹³The Laboratory of Pediatric Oncology (Bonkolab), University Hospital Rigshospitalet, Copenhagen, DNK
¹⁴Region Vastra Gotaland, Sahlgrenska University Hospital, Gothenburg, Sweden
¹⁵Children´s Cancer Centre, Queen Silvia Children´s Hospital, Sahlgrenska University Hospital, Gothenburg, Sweden

Natalie Rafaeli, MD¹, David Marin, MD², Celina Ledesma^2*, Nitin Jain, MD³, Priti Tewari, MD^4*, Issa F. Khouri, MD², Amanda L. Olson, MD⁵, Gheath Alatrash, PhD, DO⁶, Nicholas J. Short, MD³, Elias Jabbour, MD⁵, Katy Rezvani, MD⁷, Amin M. Alousi, MD^2*, Uday Popat, MD², Richard E. Champlin, MD², Elizabeth J. Shpall, MD² and Partow Kebriaei, MD¹

¹MD Anderson Cancer Center, Houston, TX
²Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Pediatrics, Pediatric Stem Cell Transplantation and Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, TX
⁵The University of Texas MD Anderson Cancer Center, Houston, TX
⁶Department of Stem Cell Transplantation and Cellular Therapy, MD Anderson Cancer Center, Pearland, TX
⁷Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas M D Anderson Cancer Center, Houston, TX

Diane Habib, MD^1*, Hagop M. Kantarjian, MD², Fadi G. Haddad, MD³, Nicholas J. Short, MD³, Nitin Jain, MD³, Jayastu Senapati, MD, DM, MBBS³, Kelly S. Chien, MD⁴, Guillermo Garcia-Manero, MD³, Zena Komrokji^5*, Tapan M. Kadia, MD³, Naval Daver, MD⁶, Courtney D. DiNardo, MD, MSc⁷, Koji Sasaki, MD³, Rebecca Garris^3*, Farhad Ravandi, MBBS⁸ and Elias Jabbour, MD⁹

¹HCA Houston Healthcare Kingwood, Spring, TX
²The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Leukemia, MD Anderson, Houston, TX
⁵Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL
⁶MD Anderson Cancer Center, Houston, TX
⁷Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX
⁸Department of Leukemia, University of Texas- MD Anderson Cancer Center, Houston, TX
⁹Department of Leukemia, University of Texas M.D. Anderson Cancer Ctr., Houston, TX

Xiaoyuan Gong, MD^1,2*, Qiuyun Fang, MD^1,2*, Runxia Gu, MD^1,2*, Shaowei Qiu, MD^1,2*, Kaiqi Liu^1,3*, Dong Lin, MD^1,2*, Chunlin Zhou, MD^1,2*, Shuning Wei^1,2*, Guangji Zhang^1,2*, Benfa Gong^1,2*, Yuntao Liu^1,2*, Yan Li, MD^1,2*, Shouyun Li, MD^1,2*, Bingcheng Liu^1,2*, Wang Ying, M.D.^1,4*, Hui Wei, MD^1,5*, Yingchang Mi, MD^1,5 and Jianxiang Wang, MD^1,2

¹Tianjin Institutes of Health Science, Tianjin, China
²National Clinical Research Center for Blood Diseases, State Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Tianjin, China
³State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
⁴4. Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
⁵State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences&Peking Union Medical College, Tianjin, China

Etan Orgel, MD, MS¹, Michael J. Burke, MD^2*, John A. Kairalla, PhD³, Emily Hibbitts, PhD^3*, Meenakshi Devidas, PhD, MBA⁴, Michael J. Borowitz, MD, PhD⁵, Brent L. Wood, MD, PhD^6,7, Nyla A. Heerema, PhD^8*, Andrew J. Carroll, PhD⁹, Kelly Maloney, MD^10*, Leonard A. Mattano, MD¹¹, Anne Angiolillo, MD^12*, Eric C. Larsen, MD^13*, Wanda L. Salzer, MD¹⁴, David T. Teachey, MD¹⁵, Naomi J. Winick, MD¹⁶, William L. Carroll, MD¹⁷, Stephen P. Hunger, MD¹⁸, Elizabeth A. Raetz, MD¹⁹ and Mignon L. Loh, MD, PhD²⁰

¹Cancer and Blood Disease Institute, Children's Hospital of Los Angeles, Los Angeles, CA
²Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI
³University of Florida - Children's Oncology Group, Gainesville, FL
⁴St Jude Children's Research Hospital, Memphis, TN
⁵Johns Hopkins University School of Medicine, Baltimore, MD
⁶Keck School of Medicine of University of Southern California, Los Angeles, CA
⁷Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA
⁸Ohio State University, Columbus, OH
⁹Department of Genetics, University of Alabama at Birmingham, Birmingham, AL
¹⁰Children's Hospital Colorado, Aurora, CO
¹¹HARP Pharma Consulting, LLC, Mystic, CT
¹²Servier Pharmaceuticals, Boston, MA
¹³Maine Children's Cancer Program, Scarborough, ME
¹⁴U.S. Army Medical Research and Materiel Command, Olney, MD
¹⁵Division of Oncology, Children's Hospital of Philadelphia, Rutledge, PA
¹⁶Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX
¹⁷Perlmutter Cancer Center, Department of Pediatrics and Pathology, NYU Grossman School of Medicine, New York, NY
¹⁸Division of Oncology, Childrens Hospital of Philadelphia, Philadelphia
¹⁹Department of Pediatrics, NYU Langone Health, New York, NY
²⁰Ben Towne Center for Childhood Cancer Research, Seattle Children’s Hospital, Fred Hutch Cancer Center, University of Washington, Seattle, WA

Marion Strullu^1*, Arnaud Petit, MD, PhD^2,3*, Carine Halfon-Domenech, MD^4*, Anne-France Ray-Lunven, MD^1*, Paul Saultier^5*, Wadih Abou Chahla, MD^6*, Stéphane Ducassou^7*, Marlène Pasquet, MD^8*, Caroline Thomas, MD^9*, Cécile Pochon^10*, Virginie Gandemer^11*, Catherine Paillard, MD, PHD^12*, Alexandre Theron, MD^13*, Claire Pluchart, MD^14*, Pascale Schneider, MD, PhD^15*, Damien Bodet^16*, Isabelle Pellier, PhD^17*, Pierre Simon Rohrlich^18*, Anne-France Jourdain^19*, Pauline Simon^20*, Frederic Millot^21*, Liana Carausu^22*, Corinne Armari Alla, PhD^23*, Camille Leglise^24*, Justyna Kanold^25*, Claire Desplantes^26*, Sandrine Thouvenin^27*, Christophe Piguet^28*, Nicolas Boissel, MD, PhD²⁹, Wendy Cuccuini, MD, PhD^30*, Vahid Asnafi^31*, Aurélie Caye-Eude^32*, Hélène Cavé, PhD^33*, Guy Leverger, MD, PhD^34*, Jean-François Benoist^35*, Yves Bertrand, MD^36*, Sylvie Chevret^37* and André Baruchel, MD, PhD³⁸

¹Pediatric Hematology, Hopital Robert Debré, AP-HP, Paris, France
²Hôpital Armand Trousseau, APHP, PARIS, Île-de-France, France
³Sorbonne Université, Paris, France
⁴Institut D'Hématologie Et D'Oncologie Pédiatrique, Lyon, France
⁵APHM, Marseille, France
⁶Department of Pediatric Hematology, Centre Hospitalo-Universitaire de Lille, Lille, France
⁷Service d'onco-hématologie pédiatrique, Hôpital Pellegrin Tripode, Bordeaux, France
⁸Department of Pediatric Hematology and Oncology, Centre Hospitalo-Universitaire de Toulouse, Toulouse, France
⁹Pediatric Oncology, CHU Nantes, Nantes, FRA
¹⁰Nancy University Hospital, Pediatric onco-hematology department, Vandoeuvre lès Nancy, France
¹¹Pediatric BMT Unit, Rennes, France
¹²Pediatric Oncology, CHRU Strasbourg, Strasbourg, FRA
¹³Pediatric Oncology, CHU Montpellier, Montpellier, FRA
¹⁴Pediatric Oncology, CHU de Reims, Reims, France
¹⁵Pediatric Hematology, Immunology, Oncology and Stem Cells Transplantation, Rouen University Hospital Charles Nicolle CHU Rouen, Rouen, France
¹⁶Pediatric Oncology, CHU De Caen,, Caen, FRA
¹⁷Pediatric Oncology, CHU Angers, Angers Cedex, FRA
¹⁸Department of Pediatric Hematology and Oncology, Centre Hospitalo-Universitaire de Nice, Nice, PACA, France
¹⁹Pediatric Oncology, CHU de Tours, Tours, France
²⁰Hématologie et oncologie pédiatrique,, CHRU de Besancon, Besancon, France
²¹Pediatric Oncology, CHU Poitiers, Poitiers, France
²²Department of Pediatric Hematology and Oncology,, Centre Hospitalo-Universitaire de Brest, Brest, France, Brest, France
²³Pediatric Oncology, CHU Grenoble Hôpital Couple Enfant, GRENOBLE, FRA
²⁴Department of Pediatric Oncology, Hematology, Immunology,, University Hospital of Amiens, Amiens, France
²⁵Pediatric Oncoloy, CHU Clermont Ferrand, Clermontferrand, FRA
²⁶Pediatric Oncology, CHU de Dijon, Dijon, France
²⁷Pediatric Oncology, CHU Saint Etienne, Saint Etienne, FRA
²⁸Pediatric Oncology, CHU Limoges, Limoges, FRA
²⁹Hematology Adolescents and Young Adult Unit, Saint-Louis Hospital, APHP, Paris, France, Paris Cedex 10, Paris, France
³⁰Saint Louis Hospital, Paris, France
³¹Hematology Department, Université Paris Descartes Sorbonne Cité, Institut Necker-Enfants, Paris, FRA
³²Department of Genetics, University Hospital Robert Debré, Assistance Publique Des Hôpitaux, Paris, France
³³Department of Genetics, Hôpital Robert Debré, Paris, France
³⁴Pediatric Hematology Oncology Immunology Department, Hôpital Trousseau, Paris, France
³⁵Biochemistry Department, Hôpital Universitaire Necker Enfants Malades, Paris, France
³⁶Pediatric Hematology, Institut d'Hématologie et Oncologie Pédiatrique, Lyon, France
³⁷Biostatistics and Medical Information Department, Saint Louis Hospital, Assistance Publique — Hôpitaux de Paris (AP-HP), Paris, France
³⁸Department of Pediatric Hematology and Immunology,, University Hospital Robert Debré, Assistance Publique des Hôpitaux de Paris (APHP), Paris, France

Lijuan Hu^1*, Ya-Zhe Wang^2*, Xiang Wang^2*, Zongru Li, MD^2*, Ting Zhao^3*, Wenbing Duan^4*, Lu Yu^5* and Qian Jiang, MD⁶

¹Peking University People’s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Bejing, China
²Peking University People’s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China
³Peking University People’s Hospital, Peking University Institute of Hematology National Clinical Research Center for Hematologic Disease, China, Beijing, China
⁴Department of Hematology, Peking University People's Hospital, Beijing, China
⁵National Clinical Research Center for Hematologic Disease, Peking University People’s Hospital, Peking University Institute of Hematology, Beijing, China
⁶National Clinical Research Center for Hematologic Disease, Peking University People’s Hospital, Peking University Institute of Hematology, Beijing, Beijing, China

Angus Hodder, MBBS^1,2*, Avijeet Kumar Mishra, MD, MBBS^3*, Philip Connor^4*, Michelle Cummins^5*, Danny Cheng, MA, MBBS, MRCP^1*, Michael Gattens^6*, Brenda Gibson, MD^7*, Danielle Ingham^8*, Katherine Lindsay^9*, Andrea Malone, MD^10*, Majid Madni^11*, John Moppett^12*, Jayashree Motwani^13*, Pritesh Patel^14*, Subramaniam Ramanathan, MD, DM^15*, Anindita Roy, MD, PhD¹⁶, Beki James, MD^17*, Phil Ancliff^1*, Ajay Vora¹ and Jack Bartram^1*

¹Great Ormond Street Hospital for Children, London, United Kingdom
²Wellcome Sanger Institute, London, United Kingdom
³Cincinnati Children's Hospital, Cincinnati, OH
⁴Children's Hospital For Wales, Cardiff, GBR
⁵Bristol Royal Hospital For Children, Bristol, GBR
⁶Addenbrookes Hospital, Cambridge, Cambridge, GBR
⁷Department of Paediatric Haematology, Royal Hospital for Sick Children, Glasgow, United Kingdom
⁸Leeds Children's Hospital, Leeds, GBR
⁹Alder Hey Children's Hospital, Liverpool, United Kingdom
¹⁰Children’s Health Ireland, Dublin, IRL
¹¹Department of paediatric haematology and oncology, Nottingham University Hospitals, Nottingham, United Kingdom
¹²Bristol Royal Hospital For Sick Children, Bristol, GBR
¹³Birmingham Children's Hospital, Birmingham, GBR
¹⁴Great Ormond Street Hospital, London, United Kingdom
¹⁵Newcastle Upon Tyne NHS Foundation Trust, Newcastle Upon Tyne, ENG, GBR
¹⁶Department of Paediatrics, University of Oxford, Oxford, United Kingdom
¹⁷Leeds Teaching Hospital NHS Trust, Leeds, United Kingdom

Xiaopei Lily Zeng, MD^1,2, Soyang Kwon, PhD^2,3*, Anant Vatsayan, MBBS⁴, Christina Baggott, PhD^5*, Snehit Prabhu, PhD^6*, Samuel John, MD^7*, Holly L. Pacenta, MD^8*, Christine L. Phillips, MD^9,10, Jenna Rossoff, MD^1,2, Julie-An Talano, MD¹¹, Amy Moskop, MD¹¹, Michael R Verneris, MD¹², Douglas D. Myers, MD^13*, Erin Marie Hall, MD^13*, Nicole A Karras, MD^14*, Challice L. Bonifant, MD, PhD¹⁵, Muna Qayed, MD^16,17, Michelle L. Hermiston, MD, PhD¹⁸, Prakash Satwani, MD, MBBS¹⁹, Christa Krupski, DO, MPH^10,20*, Amy K Keating, MD^21,22,23*, Susanne H.C. Baumeister, MD^21,22,23, Vanessa A. Fabrizio, MD¹², Vasant Chinnabhandar, MD, MBBS^24*, Emily Egeler^6*, Sharon Mavroukakis, MS^6*, Khanh Nguyen^6*, Kevin J. Curran, MD^25,26*, Crystal L. Mackall, MD^5,6,27, Theodore W. Laetsch, MD^28,29*, Liora Michal Schultz, M.D.⁵ and Kevin O. McNerney, MD, MSc^1,2

¹Division of Hematology, Oncology, Neuro-oncology, and Stem Cell Transplant, Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL
²Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL
³Stanley Manne Children's Research Institute, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL
⁴Center for Cancer and Blood Disorders, Children's National Hospital, Washington, DC
⁵Department of Pediatrics, Stanford University School of Medicine, Stanford, CA
⁶Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA
⁷Department of Pediatrics, Division of Hematology-Oncology, University of Texas Southwestern Medical Center, Dallas, TX
⁸Cook Children's Hospital, Fort Worth, TX
⁹Cancer and Blood Diseases Institute, Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
¹⁰Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH
¹¹Department of Pediatrics, Division of Pediatric Hematology, Oncology, Blood and Marrow Transplant, Medical College of Wisconsin and Children's Wisconsin, Milwaukee, WI
¹²Department of Pediatrics, Division of Hematology, Oncology, and Bone Marrow Transplantation, University of Colorado School of Medicine and Children's Hospital of Colorado, Aurora, CO
¹³Department of Hematology, Oncology and Blood and Marrow Transplantation, Children's Mercy Hospital, University of Missouri Kansas City, Kansas City, MO
¹⁴Department of Pediatrics, City of Hope National Medical Center, Duarte, CA
¹⁵Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD
¹⁶Emory University, Winship Cancer Institute, Atlanta, GA
¹⁷Division of Pediatric Hematology, Oncology and Bone Marrow Transplantation, Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA
¹⁸Department of Pediatric, Division of Pediatric Hematology-Oncology, University of California San Francisco, Benioff Children’s Hospital, San Francisco, CA
¹⁹Department of Pediatrics, Division of Pediatric Hematology, Oncology and Stem Cell Transplant, Columbia University Medical Center, New York, NY
²⁰Cancer and Blood Disease Institute, Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
²¹Division of Pediatric Hematology-Oncology, Boston Children's Hospital, Boston, MA
²²Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA
²³Department of Pediatrics, Harvard Medical School, Boston, MA
²⁴Department of Pediatric Oncology, Hematology, Blood and Marrow Transplantation, Perth Children's Hospital, Nedlands, Australia
²⁵Department of Pediatrics, Weill Cornell Medical College, New York, NY
²⁶Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY
²⁷Department of Medicine, Division of Blood and Marrow Transplantation & Cellular Therapy, Stanford University School of Medicine, Stanford, CA
²⁸Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA
²⁹Department of Pediatrics and Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

Tingting Yang^1,2,3*, Yetian Dong^1,2,3*, Mingming Zhang^2,3,4*, Jingjing Feng^1,2,3*, Shan Fu^2,3,5*, Pingnan Xiao^1,2,3*, Ruimin Hong^2,3,5*, Huijun Xu^2,3,6*, Jiazhen Cui^1,2,3*, Simao Huang^1,2,3*, Guoqing Wei^1,2,3*, Alex H. Chang^7*, He Huang, MD^1,2,8* and Yongxian Hu^1,2,3*

¹Bone Marrow Transplantation Center of The First Affiliated Hospital Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China
²Institute of Hematology, Zhejiang University, Hangzhou, China
³Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy, Hangzhou, China
⁴Bone Marrow Transplantation Center of The First Affiliated Hospital Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⁵Bone Marrow Transplantation Center, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
⁶Bone Marrow Transplantation Center of The First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China
⁷Shanghai YaKe Biotechnology Ltd, Shanghai, China
⁸Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy, hangzhou, China

Yoshihiro Hatta, MD¹, Fumihiko Hayakawa, MD², Etsuko Yamazaki, MD³, Tohru Murayama, MD, PhD^4*, Takeshi Saito, MD⁵, Masatsugu Tanaka, MD^6*, Noriko Doki⁷, Tetsuya Nishida, MD PhD^8*, Yuna Katsuoka, MD^9*, Satoru Takada, MD^10*, Tatsuhiro Sakamoto, MD, PhD^11*, Shinya Sato, MD^12*, Yoshiko Atsuta, MD, PhD^13*, Shigeki Ohtake, MD^14*, Emiko Sakaida, MD PhD¹⁵, Yoshinobu Maeda, MD, PhD¹⁶, Takahiro Yamauchi, MD¹⁷, Itaru Matsumura, MD¹⁸, Yasushi Miyazaki, MD, PhD¹⁹ and Hitoshi Kiyoi, MD PhD²⁰

¹Department of Medicine Division of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan
²Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, JPN
³Dept. Hematology, Yokohama Rosai Hospital, Yokohama, Japan
⁴Dept. Hematology, Hyogo Cancer Center, Akashi, Japan
⁵Division of Clinical Oncology/Hematology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
⁶Department of Hematology, Kanagawa Cancer Center, Kanagawa, Japan
⁷Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
⁸Department of Hematology, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, Nagoya, Japan
⁹National Hospital Organization Sendai Medical Center, Sendai, JPN
¹⁰Leukemia Research Center, Saiseikai Maebashi Hospital, Maebashi, Japan
¹¹Department of Hematology, University of Tsukuba Hospital, Tsukuba, Japan
¹²Department of Hematology, Nagasaki University Hospital, Nagasaki, JPN
¹³Japanese Data Center for Hematopoietic Cell Transplantation, Nagakute, Japan
¹⁴Kanazawa University, Kanazawa, Japan
¹⁵Department of Hematology, Chiba University Hospital, Chiba City, Japan
¹⁶Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
¹⁷Department of Hematology and Oncology, University of Fukui, Fukui, Japan
¹⁸Department of Hematology and Rheumatology, Kindai University Faculty of Medicine, Osaka-Sayama, Japan
¹⁹Department of Hematology, Nagasaki University Hospital, Nagasaki, Japan
²⁰Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan

Katherine Tobon, PharmD, BS^1*, Kylie Consalvo, PharmD^2*, Syeda Saba Kareem, PharmD^1*, Jeffrey E Lancet, MD¹, Rami S. Komrokji, MD¹, Javier Pinilla-Ibarz, MD, PhD³, David Sallman, MD¹, Jennifer Eatrides, MD^4*, Alison R. Walker, MD, MBA, MPH¹, Julio C. Chavez, MD¹, Leidy L. Isenalumhe, MD, MS¹ and Bijal D Shah, MD¹

¹Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL
²Moffitt Cancer Center, Tampa
³Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
⁴Department of Community and Satellite Oncology, Moffitt Cancer Center, Tampa, FL

Elias Jabbour, MD¹, Hagop M. Kantarjian, MD¹, Ibrahim Aldoss, MD², Pau Montesinos, PhD, MD^3*, Jessica T. Leonard, MD⁴, David Gomez-Almaguer, MD⁵, Maria R. Baer, MD⁶, Carlo Gambacorti-Passerini, MD, Prof.⁷, James McCloskey, MD⁸, Yosuke Minami, MD, PhD⁹, Cristina Papayannidis, MD, PhD^10*, Vanderson Rocha, MD, PhD, MS^11*, Philippe Rousselot, MD PhD^12*, Pankit Vachhani, MD^13*, Eunice S. Wang, MD¹⁴, Lin Yang, PhD, MSc^15*, Meliessa Hennessy, MPH^15*, Alexander Vorog, MD^15*, Niti Patel, PhD^15*, Tammie Yeh, PhD^15* and Josep-Maria Ribera, MD, PhD¹⁶

¹The University of Texas MD Anderson Cancer Center, Houston, TX
²City of Hope – Duarte, Duarte, CA
³Hospital Universitari i Politecnic La Fe de Valencia, Valencia, Spain
⁴Oregon Health and Science University, Portland, OR
⁵Hospital Universitario, UANL; Dr. José Eleuterio Gonzalez, Monterrey, Mexico
⁶University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD
⁷University Milano-Bicocca, Monza, Italy
⁸Hackensack University Medical Center, Hackensack, NJ
⁹National Cancer Center Hospital East, Kashiwa, Japan
¹⁰IRCCS Azienda Ospedaliero-Universitaria di Bologna Istituto di Ematologia “Seràgnoli”, Bologna, Italy
¹¹Instituto do Câncer do Estado de São Paulo, University of São Paulo, São Paulo, Brazil
¹²Hospital Mignot University de Versailles Saint-Quentin-en-Yvelines, Paris, France
¹³University of Alabama at Birmingham, Birmingham, AL
¹⁴Roswell Park Comprehensive Cancer Center, Leukemia Service, Buffalo, NY
¹⁵Takeda Development Center Americas, Inc., Cambridge, MA
¹⁶ICO-Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain

Qingsong Yin, PhD^1*, Taotao Liang^2,3*, Shan Wang^2*, Yuqing Chen^4*, Wenli Zuo^2*, Qinglan Zhang^2*, Hongxia Ma^5*, Hao Ai^2*, Qian Wang^1* and Hongfei Wu^2*

¹Department of Hematology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China
²Department of Hematology, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China
³Henan Cancer Hospital, Zhengzhou, China
⁴Department of Hematology, Henan Province People's Hospital, Zhengzhou, China
⁵The third people's hospital of zhengzhou city, Zhengzhou, China

Anna Z Castleton^1*, Michelle Lannon, MBBS, MRCP, FRCPath^2*, Ned Atiyah, BSc (Hons) Biomed Sci, MA Public Health^3*, Alexandra Smith, PhD^3*, Lindsay George, PhD, FRCPath^4*, Sridhar Chaganti, MD, PhD, FRCPath, MRCP^4*, Eleni Tholouli, MD, PhD, FRCPath^5*, Pakhshan Farshi, MD^5*, Nicholas Cunningham, MD, BSc, FRCPath^6*, Claire Arnold^6*, Nick Morley^7*, Philippa Kelsey, MBChB MRCP FRCPath^7*, Prudence Hardefeldt, MBBS (hons), MPhil, FRACP, FRCPA^8*, Katja Kimberger^9*, Manish Jain, FRCPath, MBBS^10*, Maeve O'Reilly^11*, Richard Burt, PhD, FRCPath, MRCP^12*, Tobias Menne, PhD^2*, Ahmed Abdulgawad, MSc, PhD, MRCP, FRCPath^1*, Katharine Hodby, BMCh(Ox), FRCPath^13*, Aniruddha Dayama, MD^13*, David A. Irvine, PhD, FRCPath, MRCP¹⁴, Anne Louise Latif^14*, Deborah Susan Richardson, MD, FRCP, FRCPath, MA, MBBChir¹⁵, Mariam Amer^16*, Ram Malladi, MD, PhD^17*, James Aries, MBChB, MRCP, FRCPath, PhD^18*, Seda Cakmak^18*, Johannes De Vos^18*, Gerardo Errico^19*, Emma Nicholson, MD^20*, Kirsty Marie Sharplin, MBBS^21*, Andrew Peniket^21*, Bela Patel Wrench, MDRes^22*, Anthony Moorman^23*, Clare Rowntree^24*, David Marks^25*, Adele Fielding^26* and Deborah Yallop, MD, PhD^27*

¹The Christie NHS Foundation Trust, Manchester, United Kingdom
²Northern Centre for Cancer Care, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom
³Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, United Kingdom
⁴University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom
⁵Manchester Royal Infirmary, Manchester, United Kingdom
⁶Belfast City Hospital, Belfast, United Kingdom
⁷Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom
⁸King's College Hospital NHS Foundation Trust, London, United Kingdom
⁹Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
¹⁰Leeds Teaching Hospital NHS Trust, Leeds, United Kingdom
¹¹Department of Hematology, University College London Hospitals, London, United Kingdom
¹²University College London Hospitals, London, United Kingdom
¹³University Hospitals Bristol NHS Trust, Bristol, United Kingdom
¹⁴Queen Elizabeth University Hospital, Glasgow, United Kingdom
¹⁵University Hospitals Southampton, Southampton, United Kingdom
¹⁶University Hospital Southampton, Southampton, United Kingdom
¹⁷Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom
¹⁸Barts Health NHS Trust, London, United Kingdom
¹⁹Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom
²⁰Royal Marsden NHS Foundation Trust, London, United Kingdom
²¹Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
²²Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom
²³Leukaemia Research Cytogenetics Group, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom
²⁴University Hospital of Wales, Cardiff, United Kingdom
²⁵Department of Hematology, University Hospitals Bristol, Bristol, United Kingdom
²⁶University of York, York, United Kingdom
²⁷King’s College Hospital, London, United Kingdom

Changwen Xue^1,2*, Yingjin Zhang^1,3*, Chao Wu^1,3*, Wenyu Yang^1,3*, Yao Zou^1,4*, Ye Guo^1,5*, Yumei Chen^1,5*, Xiaojuan Chen, MD^1,5*, Yueshen Ma^1,3*, Xiaofan Zhu, MD^1,4 and Li Zhang^1,3*

¹Tianjin Institutes of Health Science, Tianjin, China
²State Key Laboratory of Experimental Hematology, National Clinical Research Cent, Tianjin, China
³State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology& Blood Diseases Hospital, Chinese Academy of Medical Sciences& Peking Union Medical College, Tianjin, China
⁴State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, CAMS & PUMC, Tianjin, China
⁵Department of Pediatric Hematology and Oncology, State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology& Blood Diseases Hospital, Chinese Academy of Medical Sciences& Peking Union Medical College, Tianjin, China

Ajibade Ashaye, MD, MS, MBA, MPH¹, Ling Shi, PhD^2*, Ibrahim Aldoss, MD³, Pau Montesinos, PhD, MD^4*, Pankit Vachhani, MD^5*, Cristina Papayannidis, MD, PhD⁶, Jessica T. Leonard, MD⁷, Maria R. Baer, MD⁸, Josep-Maria Ribera, MD, PhD⁹, James McCloskey, MD¹⁰, Jianxiang Wang, MD¹¹, Sujun Gao^12*, Deepali Rane, MBBS, MPH^1* and Shien Guo, PhD^2*

¹Takeda Development Center Americas, Inc., Cambridge, MA
²Evidera Inc., Bethesda, MD
³City of Hope National Medical Center, Duarte, CA
⁴Hospital Universitari i Politècnic La Fe, Valencia, Spain
⁵University of Alabama at Birmingham, Birmingham, AL
⁶IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “L. e A. Seràgnoli”, Bologna, Italy
⁷Oregon Health and Science University, Portland, OR
⁸University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD
⁹ICO – Hospital Germans Trias i Pujol, Josep Carreras Leukaemia Research Institute, Badalona, Spain
¹⁰Hackensack University Medical Center, Hackensack, NJ
¹¹Institute of Hematology & Blood Diseases Hospital of CAMS & PUMC, Tianjin, China
¹²The First Hospital of Jilin University, Changchun, China

Macarena Ottobre, MD^1*, Laura Colitto^2*, Maria Ines Marcone^3*, Eliana Krystal^2*, Lorena Moran, MD^4*, Laureana Eleonora Wittmund, MD^2*, Vanesa Gimenez, MD^5* and Monica Makiya^6*

¹Hospital de Niños Dr. Ricardo Gutiérrez, Buenos Aires, Argentina
²Hospital de Niños Dr. Ricardo Gutiérrez, CABA, Argentina
³Hospital de Niños Dr. Ricardo Gutiérrez, Buenos Aires, BA, Argentina
⁴Hospital De Niños R. Gutiérrez, Hematology and Oncology Department, CABA, Argentina
⁵Hospital Interzonal de Agudos Especializado en Pediatría Sor María Ludovica, La Plata, ARG
⁶Hospital Italiano de Buenos Aires, Buenos Aires, BA, Argentina

Francesca Del Bufalo, MD, PhD^1*, Andrej Lissat, MD, PhD^2*, Chiara Rosignoli, MD^1*, Veerle Mondelaers, MD^3*, Christophe Chantrain, MD, PhD^4*, Jochen Büchner, MD, PhD^5*, Roberto Carta, MD^1*, Marco Becilli, MD^1*, Jonas Eggeling, MD^2*, Federica Galaverna, MD, PhD^1*, Stefania Gaspari, MD^1*, Maria Giuseppina Cefalo, MD^1*, Arend von Stackelberg, MD^2* and Franco Locatelli, MD^1,6

¹Department of Hematology-Oncology and Cell and Gene Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, Italy
²Department of Hematology and Oncology, Charité Universitätsmedizin Berlin, Berlin, Germany
³Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, UZ GENT, Ghent, BEL
⁴Division of Pediatric Hematology-Oncology, Centre Hospitalier Chrétien (CHC), MontLégia, Liege, Belgium
⁵Oslo University Hospital, Oslo, Norway
⁶Catholic University of the Sacred Heart, Rome, Italy

Tingting Zhang^*, Li Liu, MD^*, Xiaohui Zheng^*, Biao Shen^*, Ming Gong^*, Xin Liu^*, Gang Li^*, Ying Zhang^*, Wenbin Cao^*, Chen Liang^*, Aiming Pang^*, Yi He^*, Donglin Yang^*, Sizhou Feng^*, Mingzhe Han^* and Erlie Jiang^*

Institute of Haematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China

Etan Orgel, MD, MS^1,2, Sarah K Tasian, MD³, Yueh-Yun Chi, PhD^4,5*, Jemily Malvar, MS^6*, Christina M. Dieli-Conwright^7*, Rubi Buxton^8*, Mackenzie Frederick, RD^9*, Hannah Williams^10*, Karen R Rabin, MD, PhD¹¹, Susan R Rheingold, MD¹², Robin Norris, MD, MS, MPH¹³, Tamara P. Miller, MD, MSCE¹⁴, Brent L. Wood, MD, PhD^5,15, Ellynore Florendo^8*, Ellen Chang, MD^16*, Lisa Hartman^17*, Mallorie M. Heneghan, MD¹⁸, Michelle L. Hermiston, MD, PhD¹⁹, Joel Kaplan, DO^20*, Tamra Slone, MD^21*, Deepa Bhojwani, MD²², Alan S. Wayne, MD²³ and Steven D. Mittelman^24*

¹Cancer and Blood Disease Institute, Children's Hospital of Los Angeles, Los Angeles, CA
²Keck School of Medicine of Medicine, University of Southern California, Los Angeles, CA
³Division of Oncology & Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA
⁴Biostatistics, Children's Hospital of Los Angeles, Los Angeles, CA
⁵Keck School of Medicine of University of Southern California, Los Angeles, CA
⁶Biostatistics, Children's Hospital Los Angeles, Los Angeles, CA
⁷Dana Farber Cancer Institute, Boston
⁸Childrens Hospital Los Angeles, Los Angeles, CA
⁹Texas Children's Cancer and Hematology Centers, Baylor College of Medicine/Texas Children's Hospital, Houston, TX
¹⁰Children's Hospital of Philadelphia, Philadelphia, PA
¹¹Department of Pediatrics, Baylor College of Medicine TX Children's Cancer Center, Houston, TX
¹²Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA
¹³Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
¹⁴Department of Pediatrics, Division of Hematology, Oncology, and Bone Marrow Transplant, Emory University School of Medicine, Atlanta, GA
¹⁵Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA
¹⁶Division of Oncology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
¹⁷University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO
¹⁸Ann & Robert Lurie Children's Hospital, Salt Lake City, UT
¹⁹Department of Pediatric, Division of Pediatric Hematology-Oncology, University of California San Francisco, Benioff Children’s Hospital, San Francisco, CA
²⁰Levine Children's Hosp. at Carolinas Med. Ctr., Charlotte, NC
²¹Univ. of TX, Southwestern, Dallas, TX
²²Hematology/Oncology, Children's Hospital of Los Angeles, Los Angeles, CA
²³Children's Hospital of Los Angeles, Los Angeles, CA
²⁴University California- Los Angeles, Los Angeles, CA