Chantal Lucini, PhD^*, Isabella Sponseiler, MSc^*, Julia Senkiv, PhD^*, Anna-Maria Bandian, MSc^* and Thomas Lion, MD, PhD, MSc^*

St.Anna Children´s Cancer Research Institute (CCRI), Vienna, Austria

Bram S.J. Lim^1*, Holly J. Whitfield^1*, Mi K. Trinh^1*, Gianna Bloye^2*, Rebecca Thomas^3*, Nathaniel D. Anderson^1*, Anna Wenger^1*, Angus Hodder, MBBS^3,4*, Taryn D. Treger^1,5,6*, Henry Lee-Six^1,5*, Tim H.H. Coorens, PhD^7*, Conor Parks^1*, Toochi Ogbonnah^1*, Petri Pölönen, PhD⁸, Charles G. Mullighan, MBBS, MSc, MD⁸, David T. Teachey, MD⁹, Melanie M Hagleitner, MD^10*, Lennart A. Kester, PhD^10*, Frank N. van Leeuwen, PhD¹¹, Gordon Beattie^2*, Marc R. Mansour, MD, PhD, FRCPath^2,12*, Owen Williams^12*, Jack Bartram^3*, Stuart Adams^3*, Laura Jardine^13*, Sam Behjati, BMBCh, PhD^1,5,6* and David O'Connor, MD^2,3,12*

¹Wellcome Sanger Institute, Hinxton, United Kingdom
²UCL Cancer Institute, London, United Kingdom
³Great Ormond Street Hospital for Children, London, United Kingdom
⁴Wellcome Sanger Institute, London, United Kingdom
⁵Cambridge University Hospital NHS Foundation Trust, Cambridge, United Kingdom
⁶Department of Paediatrics, University of Cambridge, Cambridge, United Kingdom
⁷Broad Institute of MIT and Harvard, Cambridge, MA
⁸Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
⁹Children's Hospital of Philadelphia, Philadelphia, PA
¹⁰Princess Maxima Center for pediatric oncology, Utrecht, Netherlands
¹¹Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands
¹²UCL Great Ormond Street Institute of Child Health, London, United Kingdom
¹³Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom

Ilaria Di Fazio^1*, Lena Behrmann, PhD^2*, Valerie de Haas, MD, PhD^3*, Victoria Dimitrova^1*, Joaquin Duarte, MD^4*, Gabriele Escherich, MD^5*, Arja Harila, MD, PhD^6*, Mats Heyman, MD, PhD^7,8, Mattias Hofmans, MD, PhD^9*, Magnus Hultdin, MD, PhD^10*, Inga Johannsdottir, MD^11*, Andrea Malone, MD^12*, Hanne Vibeke Marquart, MD, PhD^13*, Reda Matuzeviciene^14*, Veerle Mondelaers, MD^15*, John Moppett, MD, PhD^16*, Liv T. N. Osnes, MD, PhD^17*, Samuli Rounioja, MD, PhD^18*, Kjeld Schmiegelow, MD, DMsc¹⁹, Mervi Taskinen, MD^20*, Goda Vaitkeviciene, MD, PhD^21*, Inge M. van der Sluis, MD, PhD³, Lucy Wheeler^22* and Christina Halsey, MD, PhD²³

¹School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom
²University Medical Center Hamburg-Eppendorf, Hamburg, Sweden
³Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
⁴Portuguese Institute of Oncology of Lisbon, Lisbon, Portugal
⁵University Medical Center Hamburg-Eppendorf, Hamburg, Germany
⁶Women's and Children's Health, Uppsala University, Uppsala, Sweden
⁷Childhood Cancer Research Unit, Karolinska Institute, Stockholm, Sweden
⁸Astrid Lindgren Children’s Hospital, Karolinska University Hospital, Stockholm, Sweden
⁹Department of Laboratory Medicine, Ghent University Hospital, Ghent, Belgium
¹⁰Umeå University, Umeå, Sweden
¹¹Department of Pediatric Hematology and Oncology, Oslo University Hospital Rikshospitalet, Oslo, Norway
¹²Children’s Health Ireland, Dublin, IRL
¹³Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark
¹⁴Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania
¹⁵Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
¹⁶Department of Paediatric Haematology, Bristol Royal Hospital for Children, Bristol, United Kingdom
¹⁷Oslo University Hospital, Department of Immunology, Oslo, Norway, NOR
¹⁸Fimlab Laboratories, Department of Haematology, Tampere University Hospital, Tampere, Finland
¹⁹Department of Pediatrics and Adolescent Medicine, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark
²⁰Children and Adolescents, Helsinki University Hospital, Helsinki, Finland
²¹Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania
²²Southmead Hospital, North Bristol NHS Trust, Bristol, United Kingdom
²³Wolfson Wohl Cancer Research Centre, School of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

Sarah Sandmann^1*, Marcel Te Vrugt^2*, Gerrit Randau^2*, Thomas Beder^3,4,5*, Martin Neumann, MD^3*, Amelie Alfert^2*, Cornelia Eckert, MD, PhD^6*, Anja Moericke^7*, Johanna Horns^8*, Monika Brüggemann^8* and Birgit Burkhardt, MD, PhD⁹

¹Institute of Medical Informatics, University of Muenster, Muenster, DEU
²University Hospital Muenster, Department of Paediatric Hematology, Oncology and BMT and NHL-BFM study center, Muenster, Germany
³Medical Department II, Hematology and Oncology, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany
⁴Clinical Research Unit CATCH ALL (KFO 5010/1) funded by the Deutsche Forschungsgemeinschaft, Kiel, Germany
⁵University Medical Center Schleswig-Holstein, University Cancer Center Schleswig-Holstein, Kiel, Germany
⁶Department of Pediatric Oncology and Hematology, Charité University Medical Center, Berlin, Germany
⁷Christian Albrechts University Kiel and University Hospital Schleswig-Holstein, Department of Pediatrics I, Pediatric Hematology/Oncology, ALL-BFM Study Group, Kiel, Germany
⁸Medical Department II, Hematology and Oncology, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany
⁹University Hospital Muenster, Department of Paediatric Hematology, Oncology and BMT and NHL-BFM study center, Münster, Germany

Jingliao Zhang¹, Suyu Zong^2*, Yongjuan Duan^3*, Bei-bei Zhao^4*, Jun Li^5*, Xiaoli Chen^6*, Wenyu Yang, MD^7*, Peng Wu^8*, Xiaofan Zhu, MD⁷ and Yingchi Zhang^1*

¹State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, CAMS & PUMC, Tianjin, China
²State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin, China
³State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical Co, Tianjin, CHN
⁴State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical Colleg, Tianjin, China
⁵State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences&Peking Union Medical College, Tianjin, China
⁶State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, CHN
⁷Department of Pediatric Hematology and Oncology, State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology& Blood Diseases Hospital, Chinese Academy of Medical Sciences& Peking Union Medical College, Tianjin, China
⁸State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Tianjin, China

Marianna Ponzo, PhD^1,2*, Lorenzo Drufuca, PhD^3*, Chiara Buracchi, PhD^1,4*, Marco M Sindoni^1,4*, Silvia Nucera, MD^1,4*, Cristina Bugarin, MSc^1*, Ramona Bason, PhD^3*, Grazisa Rossetti, PhD^3*, Raul Bonnal^3*, Cristian Meli^5*, Benedetta Rambaldi^5*, Federico Lussana^6*, Silvia Ferrari, MD^5*, Alex Moretti, MD^1*, Giulia Risca^7*, Christian Pellegrino, PhD^2*, Markus G. Manz, MD², Stefania Galimberti^7*, Alessandro Rambaldi⁵, Andrea Biondi^1,4,8, Giuseppe Gaipa¹, Massimiliano Pagani, PhD^3,9* and Chiara F. Magnani, PhD^1,2

¹Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy
²Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Zurich, Switzerland
³The AIRC Institute of Molecular Oncology (IFOM), Milan, Italy
⁴School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy
⁵Department of Oncology-Hematology, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy
⁶Department of Oncology and Hematology, University of Milan and ASST Papa Giovanni XXIII, Bergamo, Italy
⁷Bicocca Bioinformatics, Biostatistics and Bioimaging Centre, Department of Medicine and Surgery, University of Milano - Bicocca, Milan, Italy
⁸Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy
⁹Department of Medical Biotechnology and Translational Medicine, Università degli Studi, Milan, Italy

Colin Fortner, MSc^1*, Alexandra Niedermayer, MSc^2*, Stefanie Enzenmüller, PhD^2*, Klaus-Michael Debatin, MD, Professor², Felix Seyfried, MD^2* and Lüder Hinrich Meyer, MD, Professor^2*

¹Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, AL, Germany
²Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany

Marco Beldinanzi^1*, Vittorio Bellomarino^1*, Deborah Cardinali, PhD^1*, Irene Della Starza, PhD^2*, Mabel Matarazzo^1*, Mariangela Di Trani^1*, Matteo Leoncin^3*, Clara Minotti^1*, Lara Pochintesta^4*, Erika Borlenghi, MD⁵, Caterina Alati, MD^6*, Simona Sica, MD, PhD^7*, Valentina Mancini, MD^8*, Barbara Scappini^9*, Bianca Serio, MD^10*, Marina Parisi^11*, Lucia Ammirati, MD^12*, Antonella Cucca^13*, Federico Lussana^14*, Ernesta Audisio, MD^15*, Federico Mosna^16*, Patrizia Zappasodi^17*, Monica Bocchia, MD^18*, Silvia Imbergamo^19*, Mario Luppi, MD^20*, Valeria Cardinali, MD, PhD^21*, Crescenza Pasciolla^22*, Claudio Romani^23*, Albana Lico^24*, Benedetta Cambò, MD^25*, Massimiliano Bonifacio, MD^26*, Monica Messina, PhD^27*, Daniele G. Mattei, MD²⁸, Sara Mastaglio, MD^29*, Lara Aprile, PhD, MD^30*, Monia Lunghi^31*, Anna Guarini, PhD^1*, Robin Foà, MD^1* and Sabina Chiaretti, MD, PhD¹

¹Department of Translational and Precision Medicine, Division of Hematology, Sapienza University, Rome, Italy
²AIL Roma ODV, Rome, Italy
³Azienda Ulss3 Serenissima,Hematology Unit, Ospedale dell'Angelo, Venezia, Italy
⁴ASL DI PIACENZA, OSPEDALE "GUGLIELMO DA SALICETO", Piacenza, Italy
⁵Hematology, ASST Spedali Civili di Brescia, Brescia, Italy
⁶U.O.C. Ematologia, Grande Ospedale Metropolitano Bianchi Melacrino Morelli, Reggio Calabria, Italy
⁷UOC Ematologia e Trapianto Cellule Staminali Emopoietiche, Fondazione Policlinico Universitario A. Gemelli IRCCS Roma, Rome, Italy
⁸Department of Hematology and Oncology, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy
⁹Hematology Unit, Hematology Unit, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy
¹⁰Hematology and Transplant Center, University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, Salerno, Italy
¹¹UO di Ematologia - Catania, Catania, Italy
¹²ASL Salerno - Presidio Ospedaliero Tortora Pagani, Pagani, Italy
¹³ASSL NUORO, PRESIDIO OSPEDALIERO SAN FRANCESCO, Nuoro, Italy
¹⁴Department of Oncology and Hematology, University of Milan and ASST Papa Giovanni XXIII, Bergamo, Italy
¹⁵Department of Oncology, Division of Hematology, AOU City of Health and Science of Turin, Turin, Turin, Italy
¹⁶Azienda Sanitaria dell'Alto Adige, Bolzano, ITA
¹⁷Hematology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
¹⁸Hematology, Azienda Ospedaliera Universitaria Senese, University of Siena, Siena, Italy
¹⁹Department of Medicine, Hematology and Clinical Immunology Unit, University of Padova, Padova, Italy
²⁰Hematology Unit and Chair, Department of Medical and Surgical Sciences, Azienda Ospedaliera Universitaria di Modena, University of Modena and Reggio Emilia, Modena, Italy
²¹Department of Medicine and Surgery, Division of Hematology and Clinical Immunology, S. Maria della Misericordia Hospital, Perugia, Italy
²²Ematologia, Istituto Tumori Giovanni Paolo II- Bari, Bari, Italy
²³SC di Ematologia e CTMO, Ospedale Oncologico di Riferimento Regionale "A. Businco", ARNAS "G. Brotzu", Cagliari, CA, ITA
²⁴Hematology Unit, Hematology Unit, San Bortolo Hospital, Vicenza, Italy, Vicenza, Italy
²⁵University of Parma, Parma, ITA
²⁶Department of Engineering for Innovation Medicine, Section of Innovation Biomedicine, Hematology Area, University of Verona, Verona, Italy
²⁷GIMEMA Foundation, Rome, Italy
²⁸ASO S. Croce e Carle, Cuneo, Italy
²⁹Hematology and Bone Marrow Transplant, Unit San Raffaele Scientific Institute, Milano, Milano, Italy
³⁰AZ. OSPEDALIERA SENESE, Siena, ITA
³¹Division of Hematology, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy

Ntasha Roy, MBBS, MHA^1*, Alexandra E. Kovach, MD^2,3* and Brent L. Wood, MD, PhD^1,2

¹Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA
²Keck School of Medicine of University of Southern California, Los Angeles, CA
³Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA

Carol Fries Simpson, MD¹, Lik Wee Lee, PhD^2*, Hongyue Wang, PhD^3*, Diana G. Adlowitz, PhD^4*, Philip Rock^5*, Brent L. Wood, MD, PhD^6,7, Rachel E. Rau, MD⁸, Kara L. Davis, DO^9*, Anne Angiolillo, MD^10*, Meenakshi Devidas, PhD, MBA¹¹, David T. Teachey, MD¹², Karen R Rabin, MD, PhD¹³, Birte Wistinghausen, MD¹⁴, Donald Barkauskas, PhD^15*, Robert J. Hayashi^16*, Richard Burack, MD, PhD¹⁷, Carl E Allen, MD^18,19, Michelle L. Hermiston, MD, PhD²⁰ and Ilan R. Kirsch, MD²¹

¹Department of Pediatrics, University of Rochester, Rochester, NY
²Adaptive Biotechnologies, Seattle, WA
³Department of Biostatistics, University of Rochester, Rochester, NY
⁴Department of Pediatrics; Department of Pathology & Laboratory Medicine, University of Rochester, Rochester, NY
⁵Departments of Pathology and Laboratory Medicine, Medicine, and Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, New York, USA
⁶Keck School of Medicine of University of Southern California, Los Angeles, CA
⁷Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA
⁸Ben Towne Center for Childhood Cancer Research, Seattle Children’s Hospital, Fred Hutch Cancer Center, University of Washington, Seattle, WA
⁹Stanford University, Stanford, CA
¹⁰Servier Pharmaceuticals, Boston, MA
¹¹St Jude Children's Research Hospital, Memphis, TN
¹²Division of Oncology, Children's Hospital of Philadelphia, Rutledge, PA
¹³Department of Pediatrics, Baylor College of Medicine TX Children's Cancer Center, Houston, TX
¹⁴Children’s National Medical Center, Washington, DC
¹⁵Department of Population and Public Health Sciences, Keck School of Medicine of the University of Southern California, Los Angeles, CA
¹⁶Department of Pediatrics, Division of Hematology / Oncology, Washington University School of Medicine, Saint Louis, MO
¹⁷Pathology and Laboratory Medicine, University of Rochester, Rochester, NY
¹⁸Division of Pediatric Hematology and Oncology, Baylor College of Medicine, Houston, TX
¹⁹Texas Children's Hospital, Houston, TX
²⁰Department of Pediatric, Division of Pediatric Hematology-Oncology, University of California San Francisco, Benioff Children’s Hospital, San Francisco, CA
²¹Medical Affairs, Adaptive Biotechnologies, Seattle, WA

Shu-Wei Chou, MD^1*, Meng-Yao Lu, MD^1*, Yung-Li Yang, MD, PhD^1,2*, Hsiu-Hao Chang, MD, PhD^1*, Xavier Cheng-Hong Tsai, MD, PhD³, Chia-Jui Du, MD^1* and Shiann-Tarng Jou, MD, PhD^1*

¹Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
²Department of Laboratory Medicine, National Taiwan University Cancer Center, Taipei, Taiwan
³Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan

Yang Dai, MD, PhD^1*, Bei Yu, BS^2*, Jie Zhang, MS^2*, Yu Wu, MD, PhD^3*, Zhidong Yang, MS^2*, Na Wang^2*, Tong Chen, MS^4*, Libo Hu, MS^4*, Wanqiu Yang, MS^4*, Shiang Huang, MD^2,5, Ting Liu⁶ and Xiaofei Ye^2,7*

¹Department of Hematology, Institute of Hematology, West China Hospital, Sichuan University, Chengdu, China
²Wuhan Kindstar Biotech Technology Co., Ltd, Wuhan, China
³Department of Hematology and Hematology Research Laboratory, West China Hospital, Sichuan University, Chengdu, China
⁴Sichuan Hua Xi Kindstar Medical Diagnostic Centre, Chengdu, China
⁵Kindstar Global Precision Medicine Institute, Wuhan, China
⁶Department of Hematology, West China Hospital of Sichuan University, Chengdu, China
⁷Kindstar Global Precision Medicine Institute, Wuhan, AL, China

Maria Sara Felice, MD, PhD^1*, Patricia Laura Rubio, PhD^2*, Jorge Gabriel Rossi, PhD^1*, Jorge Digiorge, PhD^1*, Elisa Olga Sajaroff, PhD^1*, Myriam Ruth Guitter, MD^1*, Carla Luciana Pennella, MD^3*, Luisina Peruzzo, MD^4*, Cristian German Sánchez La Rosa, MD^2*, Hernan Zamaro, MD^2* and Elizabeth Alfaro, MD^1*

¹Hospital Nacional de Pediatría Prof. Dr. Juan P. Garrahan, Buenos Aires, Argentina
²Hematology and Oncology Department, Hospital Nacional de Pediatría Prof. Dr. Juan P. Garrahan, Buenos Aires, Argentina
³Hospital De Pediatria J P Garrahan, Buenos Aires, ARG
⁴Hematology and Oncology Department, Hospital de Pediatría Prof. Dr. Juan P. Garrahan, Buenos Aires, Argentina

Bingqing Huang^1,2*, Yujiao Jia, MD^2,3*, Haoxu Wang^1*, Huijun Wang^3*, Qi Sun^1*, Chengwen Li^1*, Hui Wei, MD^1,2*, Yingchang Mi, MD^1,2, Xiaofan Zhu, MD^2,3, Jianxiang Wang, MD^1,2 and Zhijian Xiao, MD^2,3*

¹State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences&Peking Union Medical College, Tianjin, China
²Tianjin Institutes of Health Science, Tianjin, China
³State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Tianjin, China

Anmol Pardeshi^1*, Charlie Zhong, MPH, MS, PhD^2*, Shaobo Li, PhD^1*, Catherine Metayer, MD, PhD^3* and Joseph L. Wiemels, PhD^1*

¹Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA
²American Cancer Society, Atlanta, GA
³Division of Epidemiology, School of Public Health, University of California, Berkeley, Berkeley, CA

Gianfranco Lapietra^1*, Jordi Ribera^2*, Mireia Morgades^2*, Neus Ruiz Xiville, PhD^2*, Anna Torrent, MD^3*, Mar Mallo^4*, Jesus Maria Hernandez Rivas, MD⁵, Alberto Hernández Sánchez, MD^6*, Alberto Orfao, MD, PhD^7*, Isabel Granada, MD^8*, Jose Tomas Navarro, MD, PhD^9*, Ilaria Del Giudice^10*, Maurizio Martelli, MD^11*, Sabina Chiaretti, MD, PhD¹² and Josep-Maria Ribera, MD, PhD^13,14

¹Josep Carreras Leukemia Research Institute, Badalona (ES)/ Hematology, Department of Translational and Precision Medicine, Sapienza, University of Rome (IT), Badalona, Spain
²ICO-Hospital Germans Trias i Pujol, Institut de Recerca contra la Leucèmia Josep Carreras (IJC), Universitat Autònoma de Barcelona, Badalona, Spain
³Hematology department, Institut Català D'oncologia-Hospital Germans Trias I Pujol. Josep Carrera, Badalona, Spain
⁴Myelodysplastic Syndromes Research Group, Josep Carreras Leukaemia Research Institute, ICO-Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, Spain
⁵University of Salamanca, IBSAL, IBMCC, CSIC, Cancer Research Center, Salamanca, Spain
⁶Translational and Clinical Research Program, Cancer Research Center (IBMCC, CSIC – University of Salamanca); Cytometry Service, NUCLEUS; Department of Medicine, University of Salamanca (Universidad de Salamanca), Salamanca, Spain. IBSAL (Salamanca, Spain), Salamanca, Spain
⁷Cancer Research Center (IBMCC-CSIC/USAL-IBSAL), Cytometry Service (NUCLEUS) and Department of Medicine, University of Salamanca, Salamanca, Spain
⁸Haematology Department, Hospital Germans Trias i Pujol-Catalan Institute of Oncology., Badalona, Spain
⁹Hematology Department, ICO Badalona, Germans Trias i Pujol University Hospital. Universitat Autònoma de Barcelona. Josep Carreras Leukemia Research Institute, Badalona, Spain
¹⁰Hematology, Department of Translational and Precision Medicine, Sapienza University, Roma, Italy
¹¹Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
¹²Department of Translational and Precision Medicine, Division of Hematology, Sapienza University, Rome, Italy
¹³Ico-Hospital Universitari Germans Trias Y Pujol, Badalona, Barcelona, ESP
¹⁴Josep Carreras Leukemia Research Institute, Badalona, Barcelona, Spain., Badalona, Spain

Amani Alqahatni, MD^1*, Deepa Bhojwani, MD² and Houda Alachkar, PhamD, PhD^1,3*

¹Department of Clinical and Experimental Therapeutics, School of Pharmacy, University of Southern California, Los Angeles, CA
²Hematology/Oncology, Children's Hospital of Los Angeles, Los Angeles, CA
³Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA

Vivek M. Shastri, PhD¹, Jennifer Ahmed, PharmD^2*, Eva Spin^3*, Sonia Morales, MD^4*, Anurag K. Agrawal, MD^5*, Christine L. Phillips, MD⁶, Keith J August, MD, MS⁷, Erin M. Guest, MD⁷, Carol Hwang Lin, MD⁸, Beth Apsel Winger, MD, PhD⁹, Catherine Aftandilian, MD¹⁰, Van Thu Huynh¹¹ and Jatinder K. Lamba, PhD^1,12

¹Department of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, Gainesville, FL
²Pediatrics and Women’s Pharmacy Services, UF Health Shands Children’s Hospital, Gainesville, FL
³Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, FL
⁴Pediatric Oncology, Children's Hospital of Orange County (CHOC), Orange, CA
⁵UCSF Benioff Children's Hospital, Oakland, CA
⁶Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁷Hematology/Oncology/BMT, Children's Mercy Kansas City, Kansas City, MO
⁸Division of Oncology, Hyundai Cancer Institute, Children's Hospital of Orange County, Orange, CA
⁹Division of Pediatric Hematology-Oncology, UCSF Benioff Children's Hospital, San Francisco, CA
¹⁰Department of Pediatrics, Division of Pediatric Hematology/Oncology, Stanford University, Palo Alto, CA
¹¹Division of Oncology, Children's Hospital of Orange County, Orange, CA
¹²UF Health Cancer Center, University of Florida, Gainesville, FL