John A Ligon, MD^1*, Deepa Bhojwani, MD^2,3, Alice Dang^4*, Lingyun Ji, PhD^5*, Susan R Rheingold, MD^6,7, Xinxin Xu, MS^4*, Meenakshi Devidas, PhD, MBA⁸, John A. Kairalla, PhD⁹, Mary Shago, PhD^10*, Nyla A. Heerema, PhD^11*, Andrew J. Carroll, PhD¹², Michael J. Borowitz, MD, PhD¹³, Brent L. Wood, MD, PhD^3,14, Naomi J. Winick, MD¹⁵, William L. Carroll, MD¹⁶, Stephen P. Hunger, MD¹⁷, Elizabeth A. Raetz, MD¹⁸, Mignon L. Loh, MD, PhD^19,20,21, Sumit Gupta, MD, PhD²² and Lena E Winestone, MD²³

¹University of Florida, Gainesville, FL
²Hematology/Oncology, Children's Hospital of Los Angeles, Los Angeles, CA
³Keck School of Medicine of University of Southern California, Los Angeles, CA
⁴Children's Oncology Group, Monrovia, CA
⁵Department of Population and Public Health Sciences, University of Southern California,, Los Angeles, CA
⁶Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA
⁷Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
⁸St Jude Children's Research Hospital, Memphis, TN
⁹University of Florida - Children's Oncology Group, Gainesville, FL
¹⁰The Hospital for Sick Children, Toronto, ON, CAN
¹¹Ohio State University, Columbus, OH
¹²Department of Genetics, University of Alabama at Birmingham, Birmingham, AL
¹³Johns Hopkins University School of Medicine, Baltimore, MD
¹⁴Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA
¹⁵Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX
¹⁶Perlmutter Cancer Center, Department of Pediatrics and Pathology, NYU Grossman School of Medicine, New York, NY
¹⁷Division of Oncology, Childrens Hospital of Philadelphia, Philadelphia
¹⁸Department of Pediatrics, NYU Langone Health, New York, NY
¹⁹Ben Towne Center for Childhood Cancer Research, Seattle Children’s Hospital, Fred Hutch Cancer Center, University of Washington, Seattle, WA
²⁰Department of Pediatrics, Seattle Children’s Hospital, University of Washington, Seattle, WA
²¹Ben Towne Center for Childhood Cancer Research, Seattle Children’s Hospital, Seattle, WA
²²The Hospital For Sick Children, Toronto, ON, Canada
²³Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA

Juana Martinez, MD¹, Michelle Becker^2*, Megan Metzger, MD², Nagma Shah, MD^3*, Erin Garbes Feliciano^4*, Alberto Busmail Haylock, MD^5*, Navin Bhatt^6*, Nikolaos Spyrou, MD², John O. Mascarenhas, MD⁷, Douglas Tremblay, MD⁸, Jonathan Feld, MD⁹, Marina Kremyanskaya, MD, PhD⁷, Michal Bar-Natan, MD¹⁰ and Hannah Levavi, MD¹¹

¹NYC Health + Hospitals/Elmhurst, Icahn School of Medicine At Mt. Sinai, new york, NY
²Icahn School of Medicine at Mount Sinai, New York, NY
³Department of Medicine, NYC H+H/Elmhurst, Icahn School of Medicine at Mt. Sinai, Woodside, NY
⁴NYC Health + Hospitals/Elmhurst, Icahn School of Medicine At Mt. Sinai, Queens, NY
⁵NYC H+H Elmhurst, Icahn School of Medicine at Mount Sinai, Queens, NY
⁶Department of Medicine, NYC Health + Hospitals/Elmhurst, Icahn School of Medicine at Mount Sinai, Queens, NY
⁷Division of Hematology & Oncology, Icahn School of Medicine at Mount Sinai, New York, NY
⁸Department of Hematology and Medical Oncology, Mount Sinai School of Medicine, New York, NY
⁹Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY
¹⁰Weill Cornell Medicine and The New York Presbyterian Hospital in New York City, New York, NY
¹¹Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, Brooklyn, NY

Alexandra E. Kovach, MD^1,2*, Sara K. Silbert, MD³, Annie Luong^4*, Gerald Lu^5*, Michael Lu^5*, Hao-Wei Wang, MD, PhD^6*, Karen M Chisholm, MD, PhD⁷, Andrew Doan, MD^8,9*, Deepa Bhojwani, MD^1,10, Adam Lamble, MD^11,12, Nirali N. Shah, MD¹³, Chintan Parekh, MD^8,9, Gordana Raca, MD, PhD^1,2 and Brent L. Wood, MD, PhD^1,14

¹Keck School of Medicine of University of Southern California, Los Angeles, CA
²Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA
³Pediatric Oncology Branch, National Institutes of Health, Bethesda, MD
⁴The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA
⁵Children's Hospital Los Angeles, Cytogenomics Laboratory, Los Angeles, CA
⁶Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD
⁷University of Washington, Seattle, WA
⁸University of Southern California Keck School of Medicine, Los Angeles, CA
⁹Cancer and Blood Disease Institute, Children's Hospital Los Angeles, Los Angeles, CA
¹⁰Hematology/Oncology, Children's Hospital of Los Angeles, Los Angeles, CA
¹¹Seattle Children's - Hematology-Oncology, Seattle, WA
¹²Department of Pediatrics, University of Washington, Seattle, WA
¹³Pediatric Oncology Branch, NIH, Bethesda, MD
¹⁴Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA

Jessica Lewis-Gonzalez, PharmD^1*, Jonathon Cordova, MPhil^2*, Huining Kang^3*, Cecilia Y. Arana Yi, MD⁴, Ahmed Ibrahim^5*, Patricia Greipp, DO⁶, Anand Ashwin Patel, MD⁷, Muriel Battaglia, MD^8*, Anthony J. Perissinotti, PharmD^9*, Bernard Lawrence Marini, PharmD^10*, Martina Fraga, PharmD^11*, Dale Bixby, MD, PhD^12*, Kristen M. Pettit, MD^12,13, Patrick W. Burke, MD¹² and Charles Foucar, MD²

¹University of New Mexico, Albuquerque, NM
²University of New Mexico School of Medicine, Albuquerque, NM
³University of New Mexico Health Sciences Center, Albuquerque, NM
⁴Division of Hematology/Oncology, Mayo Clinic, Scottsdale, AZ
⁵Mayo Clinic Arizona, Phoenix
⁶Division of Hematopathology, Mayo Clinic, Rochester, MN
⁷Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL
⁸University of Chicago Medicine, Chicago
⁹University of Michigan Department of Pharmacy, Michigan Medicine, Ann Arbor, MI
¹⁰University of Michigan College of Pharmacy, Michigan Medicine, Ann Arbor, MI
¹¹University of Michigan College of Pharmacy, Michigan Medicine, Ann Arbor
¹²Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI
¹³Rogel Cancer Center, University of Michigan, Ann Arbor, MI

Adam Julian Cohen-Nowak, MD^1*, Alexander Coltoff, MD², Anand Ashwin Patel, MD³, Ehab L. Atallah, MD⁴, Mobachir El Kettani, MD^5*, John Wang, MD^1*, Emily Symes, MD⁶, Girish Venkataraman, MD, MBBS⁷, Alexa Siddon, M.D.^8*, Emily Giever, MSN, RN^9*, Rory M. Shallis, MD¹⁰, Jessica Altman, MD¹, Kirsten Bell-Burdett^1*, Talha Badar, MD¹¹, Barina Aqil, MBBS^1* and Yasmin Abaza, MD¹

¹Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL
²Medical University of South Carolina, Charleston, SC
³Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL
⁴Division of Hematology/Oncology, Medical College of Wisconsin, Milwaukee, WI
⁵Yale Cancer Center, New Haven, CT
⁶Section of Hematology/Oncology, The University of Chicago, Chicago, IL, Chicago, IL
⁷Department of Pathology, University of Chicago, Chicago, IL
⁸Section of Hematology, Department of Medicine, Yale University School of Medicine, New Haven, CT
⁹Division of Hematology/Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI
¹⁰Department of Internal Medicine, Section of Hematology, Yale School of Medicine - Yale Cancer Center, Killingworth, CT
¹¹Department of Hematology/Oncology, Mayo Clinic, Jacksonville, FL

Keli Lima, BSc^1*, César Alexander Ortiz Rojas, PhD^1*, Frederico Lisboa Nogueira, MD¹, Wellington F. Silva, MD, PhD¹, Rita de Cássia Cavaglieri Medeiros, PhD^1*, Luciana Nardinelli, PhD^1*, Aline de Medeiros Leal, PhD^1*, Elvira D. R. P. Velloso, MD, PhD¹, Israel Bendit, MD, PhD^1*, Alvaro J Alencar, MD², Charles G. Mullighan, MBBS, MSc, MD³, João Agostinho Machado-Neto, PhD^4* and Eduardo M. Rego, MD, PhD¹

¹Laboratory of Medical Investigation in Pathogenesis and Targeted Therapy in Onco-Immuno-Hematology (LIM-31), Department of Internal Medicine, Faculdade de Medicina, University of São Paulo, Sao Paulo, Brazil
²Sylvester Comprehensive Cancer Center, Division of Hematology, University of Miami, Miller School of Medicine, Miami Beach, FL
³Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
⁴Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, Sao Paulo, Brazil

Gloria Hidalgo-Gomez^1,2*, Bárbara Tazón-Vega^1*, Carlos Palacio^1,2*, Silvia Saumell, MD, PhD^1,2*, María Gabarrós-Subirà^1,2*, Andres Jerez, MD, PhD^1,2*, Adoracion Blanco^1,2*, Noemí Martínez-Morgado^2*, Víctor Navarro Garces^3*, Laura Murillo^4*, Pablo Velasco, MD⁴, Thais Murciano, MD^4*, Cristina Díaz De Heredia^4*, Francesc Bosch, MD, PhD^1,5, Gemma Armengol^6* and Margarita Ortega^1,2*

¹Experimental Hematology, Vall d'Hebron Institute of Oncology (VHIO), Hospital Universitari Vall d'Hebron, Barcelona, Spain
²Department of Hematology, Hospital Universitari Vall d'Hebron, Barcelona, Spain
³Oncology Data Science (odyssey) Group, Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Hospital Universitari, Barcelona, Spain
⁴Pediatric Oncology and Hematology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain
⁵Hematology Department, Hospital Universitario Vall d’Hebron, Barcelona, Spain
⁶Unit of Biological Anthropology, Department of Animal Biology, Plant Biology, and Ecology, Faculty of Biosciences, Universitat Autònoma de Barcelona, Barcelona, Spain

Hsi-Che Liu, MD¹, Shiann-Tarng Jou, MD^2*, Shih-Hsiang Chen, MD³, Tang-Her Jaing, MD^4*, Ting-Chi Yeh, MD^5*, Jiann-Shiuh Chen, MD^6*, Kang-Hsi Wu, MD^7*, Shih-Chung Wang, MD^8*, Chih-Cheng Hsiao, MD^9*, Te-Kau Chang, MD^10*, Meng-Yao Lu, MD^11*, Hsiu-Ju Yen, MD^12*, Fang-Liang Huang, MD^13*, Shu-Huey Chen, MD^14*, Shang-Hsien Yang, MD^15*, Yen-Lin Liu, MD^16*, Shyh-Shin Chiou, MD, PhD^17*, Chao-Ping Yang, MD^18*, Lee-Yung Shih, MD¹⁹ and Dong-Tsamn Lin, MD^2*

¹Mackay Children's Hospital and Mackay Medical College, Taipei, Taiwan
²National Taiwan University Hospital, Taipei, Taiwan
³Chang Gung Memorial Hospital, Taoyuan, TWN
⁴CHENG GUNG MEMORIAL HOSPITAL, Taoyuan, TWN
⁵Mackay Children's Hospital and Mackay Medical College, Taipei, TWN
⁶Nat'l. Cheng Kung Univ. Hospital, Tainan, TWN
⁷China Medical University Children's Hospital, Taichung City, TWN
⁸Changhua Christian Hospital, Changhua, Taiwan
⁹Chang Gung Memorial Hospital At Kaohsiung, Kaohsiung City, TWN
¹⁰China Medical University Children's Hospital, Taichung City, Taiwan
¹¹Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
¹²Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan
¹³Taichung Veterans General Hospital, Taichung City, TWN
¹⁴Taipei Medical University–Shuang Ho Hospital, Taipei, Taiwan
¹⁵Department of Pediatrics, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
¹⁶Department of Pediatrics, Taipei Medical University Hospital, Taipei, TWN
¹⁷Kaohsiung Medical University Hospital, Kaohsiung City, AL, TWN
¹⁸Chang-Gung Children's Hospital, Taoyuan, TWN
¹⁹Chang Gung University, Taoyuan, Taiwan

Laura Almási, MD^1*, Cornelia Eckert, MD, PhD^2*, Maria Thastrup, PhD^3*, Vera Münch, PhD^4*, Dániel Maszárovics^5*, Bernadett Hon-Balla, MD^5*, Lennart Lenk, PhD^6*, Gábor Barna, PhD^7*, Wenyu Yang, MD^8*, Mignon L. Loh, MD, PhD⁹, Hyoung Jin Kang, MD, PhD¹⁰, Sophia Polychronopoulou, MD, PhD^11*, Arja Harila, MD, PhD^12*, Marko Kavcic, MD, PhD^13*, Kjeld Schmiegelow, MD, PhD¹⁴, Lüder Hinrich Meyer, MD, Professor^4*, Christina Halsey, MD, PhD¹⁵ and Daniel J Erdelyi, MD, PhD^5*

¹Pediatric Center, Semmelweis University, Budapest, Hungary
²Charité Universitätsmedizin Berlin, Department of Hematology and Oncology, Berlin, Germany
³The Laboratory of Pediatric Oncology (Bonkolab), University Hospital Rigshospitalet, Copenhagen, DNK
⁴Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany
⁵Pediatric Centre, Semmelweis University, Budapest, Hungary, Budapest, Hungary
⁶Department of Pediatrics I, Pediatric Hematology and Oncology, ALL-BFM Study Group, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany, Kiel, Germany
⁷Semmelweis University, Budapest, Hungary, Budapest, HUN
⁸Department of Pediatric Hematology and Oncology, State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology& Blood Diseases Hospital, Chinese Academy of Medical Sciences& Peking Union Medical College, Tianjin, China
⁹Ben Towne Center for Childhood Cancer Research, Seattle Children’s Hospital, Fred Hutch Cancer Center, University of Washington, Seattle, WA
¹⁰Seoul National University Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea
¹¹Aghia Sophia Children’s Hospital, Athens, Athens, Greece
¹²Women's and Children's Health, Uppsala University, Uppsala, Sweden
¹³University Medical Centre, Ljubljana, SVN
¹⁴Copenhagen University, Copenhagen, DNK
¹⁵Wolfson Wohl Cancer Research Centre, School of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

Stepan Hrabovsky^1,2*, Cyril Salek^3,4, Frantisek Folber^1,2*, Jan M Horacek, MD, PhD^5,6*, Tomas Szotkowski^7,8*, Zdenek Koristek^9,10*, Jozef Lukas^11,12*, Tomas Arpas^1,2*, Denisa Bakesova^2*, Martin Cernan^7,8*, Veronika Bergerova^13*, Jiri Sramek^13*, Jan Novak^14* and Michael Doubek^1,2,15*

¹Faculty of Medicine, Masaryk University, Brno, Czech Republic
²Department of Internal Medicine, Hematology and Oncology, University Hospital Brno, Brno, Czech Republic
³Institute of Hematology and Blood Transfusion, Prague, Czech Republic
⁴Charles University in Prague, Prague, Czech Republic
⁵Department of Internal Medicine IV – Hematology, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic
⁶Department of Military Internal Medicine and Military Hygiene, University of Defence, Military Faculty of Medicine, Hradec Kralove, Czech Republic
⁷Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic
⁸Department of Haemato-oncology, University Hospital Olomouc, Olomouc, Czech Republic
⁹Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic
¹⁰Department of Hematooncology, University Hospital Ostrava, Ostrava, Czech Republic
¹¹Department of Hematology and Transfusiology, University Hospital Bratislava, Bratislava, Slovakia
¹²Faculty of Medicine, Comenius University Bratislava, Bratislava, Slovakia
¹³Hemato-oncology department, University Hospital Pilsen, Plzen, Czech Republic
¹⁴Charles University and Faculty Hospital Kralovske Vinohrady, Prague, Czech Republic
¹⁵Central European Institute of Technology (CEITEC), Brno, Czech Republic

Lyam Carlo Chacon Rangel, MD, Manuel Alejandro Cruz Martínez, MD^*, Fernando Solís-Huerta, MD^*, Juan Luis Ontiveros-Austria, MD, Sergio Rodriguez-Rodriguez, MD, MSc and Roberta Demichelis, MD

Hematology and Oncology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

Sravanti Rangaraju, MBBS¹, Kendall Diebold, CNP, MSN^2*, Pankit Vachhani, MD^3,4*, Omer Jamy, MD⁵, Kimo Bachiashvili⁶, Ravi Bhatia, MD⁷, Razan Mohty, MD⁸, Manuel Espinoza-Gutarra, MD^1,9, Joshua Oliver, PharmD^2*, Barry Diamond^10*, Kaitlin Moulton^11* and Zaid Al-Kadhimi, MD^4*

¹University of Alabama, Birmingham, AL
²University of Alabama at Birmingham, Birmingham
³Division of Hematology/Oncology, O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL
⁴University of Alabama at Birmingham, Birmingham, AL
⁵O'Neal Comprehensive Cancer Center at University of Alabama at Birmingham, Birmingham, AL
⁶O’Neal Comprehensive Cancer Center at the University of Alabama at Birmingham, Birmingham, AL
⁷Division of Hematology and Oncology, University of Alabama at Birmingham, Birmingham, AL
⁸O'Neil Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL
⁹O'Neal Comprehensive Cancer Center at University of Alabama Birmingham, Birmingham, AL
¹⁰University of Alabma at Birmingham, Birmingham
¹¹University of Alabma at Birmingham, Birmingham, AL

Maria Monica Gramatges, MD, PhD^1,2, Lauren N Sanclemente, MPH^2*, Lacey Hall, MS, CCRP, CPA^3*, Danielle L Mitchell, MPH, CCRC^2*, Olga A Taylor, MPH^2*, Tanya Shannon, MS^4*, Tyler Brown, BS^4*, Michelle M Nuño, PhD^4*, Smita Bhatia, MD, MPH⁵, Eric J. Chow, MD, MPH⁶, Kelly D. Getz, PhD^7,8*, Johann K. Hitzler, MD⁹, Amanda M Li, MD¹⁰, Kaitlin McCloskey, PhD^11*, Paul C Nathan, MD^12*, Maureen M. O'Brien, MD¹³, Serina Patel, BSc, MD^14*, Anupam Verma, MD^15*, Angela R Yarbrough, MSN^16*, Geraldine Aubert, PhD^17*, Tracie C Rosser, PhD^18*, Lisa M Jacola, PhD^3*, Philip J Lupo, PhD^1,2* and Karen R Rabin, MD, PhD¹⁹

¹Cancer and Hematology Center, Texas Children's Hospital, Houston, TX
²Department of Pediatrics, Baylor College of Medicine, Houston, TX
³Department of Psychology and Biobehavioral Sciences, St. Jude Children's Research Hospital, Memphis, TN
⁴Children's Oncology Group, Monrovia, CA
⁵Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL
⁶Seattle Children's Hospital, Seattle, WA
⁷Division of Oncology, Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, PA
⁸Division of Oncology, University of Pennsylvania, Philadelphia, PA
⁹The Hospital for Sick Children, Toronto, ON, Canada
¹⁰BC Children’s Hospital, University of British Columbia, Vancouver, BC, Canada
¹¹C S Mott Children's Hospital, Ann Arbor, MI
¹²The Hospital For Sick Children, Toronto, ON, CAN
¹³Colorado Children's Hospital and the University of Colorado School of Medicine, Aurora, CO
¹⁴Children's Hospital of Eastern Ontario, London, ON, CAN
¹⁵Inova Fairfax Hospital, Fairfax, VA
¹⁶MD Anderson Cancer Center, Houston, TX
¹⁷British Columbia Cancer Agency, Vancouver, BC, CAN
¹⁸Emory University, Atlanta, GA
¹⁹Department of Pediatrics, Division of Pediatric Hematology/Oncology, Baylor College of Medicine, Houston, TX