Nicholas Dunham^1*, Zhenjia Wang^2*, Yaseswini Neelamraju, PhD¹, Yan Guo^3*, Joyce Hardwick^4*, Bernhard Maier, PhD^4*, Cem Meydan^5*, Jorge A Gandara^5*, Tak Lee^6*, Subhash Prajapati, PhD^1*, Franck Rapaport, PhD^7*, Caroline Sheridan^6*, Paul Zumbo^5*, Michael W. Becker, MD⁸, Lars Bullinger, MD⁹, Martin P Carroll, MD¹⁰, Richard J D'Andrea, PhD, BSc¹¹, Richard Dillon, MA¹², Ross L Levine, MD⁷, Christopher Mason^5*, Ari M Melnick, MD⁶, Donna S. Neuberg, ScD¹³, Stefan Bekiranov, PhD^1*, Chongzhi Zang^2*, Utpal P. Dave, MD¹⁴ and Francine E. Garrett-Bakelman, MD, PhD^6,15

¹Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA
²Department of Genome Sciences, University of Virginia, Charlottesville, VA
³University of Miami, Miami
⁴Melvin and Bren Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN
⁵Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY
⁶Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY
⁷Memorial Sloan Kettering Cancer Center, New York, NY
⁸University of Rochester Medical Center, Rochester, NY
⁹University of Ulm, Berlin, DEU
¹⁰Division of Hematology/Oncology, Department of Medicine, The Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA
¹¹Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA, Australia, Adelaide, SA, AUS
¹²King’s College London, London, United Kingdom
¹³Department of Data Science, Dana-Farber Cancer Institute, Boston, MA
¹⁴Departments of Medicine and Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN
¹⁵Departments of Medicine and Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA

Pablo Sanchez Vela, MD^1*, Brianna Kelly^2*, Claudia Brady^3*, Jonathan Foox^4*, Jacob Glass, MD, PhD⁵, Ross L Levine, MD¹ and Alan Shih, MD, PhD²

¹Memorial Sloan Kettering Cancer Center, New York, NY
²Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
³Icahn School of Medicine at Mount Sinai, New York, NY
⁴Weill Cornell Medicine, New York, NY
⁵Leukemia Service, Department of Medicine, Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY

Annabelle J Anandappa, MD^1,2, Vidushi Trivedi^2,3*, Tiffany Merlinsky, BA^4,5*, Nicole Delgaudio^6*, Emily Guzzardi^7*, Ashley Wooten^8*, Daniel Starczynowski, PhD^8,9, Robert L. Bowman, PhD¹⁰, Ross L Levine, MD⁴ and Linde A. Miles, PhD^9,11

¹Division of Hematology & Oncology, University of Cincinnati, Cincinnati, OH
²Equal Contribution, -
³University of Cincinnati, Cincinnati, OH
⁴Memorial Sloan Kettering Cancer Center, New York, NY
⁵Weill Cornell Medicine, New York City
⁶Bioscience Graduate Program, Rockefeller University, New York City
⁷Hackensack Meridian School of Medicine, Nutley, NJ
⁸Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁹University of Cincinnati Cancer Center, Cincinnati, OH
¹⁰Department of Cancer Biology, University of Pennsylvania School of Medicine, Philadelphia, PA
¹¹Division of Experimental Hematology and Cancer Biology, Cancer & Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

Xiaorong Gu, PhD^1*, Zeinab Albadry M. Zahran, MD^2*, Ramesh Balusu, PhD³, Jaroslaw Maciejewski¹, Babal K. Jha, PhD⁴ and Yogenthiran Saunthararajah, MD⁵

¹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
²Department of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt
³University of Kansas, Kansas City, KS
⁴Center for Immunotherapy & Precision Immuno-Oncology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH
⁵Department of Translational Hematology and Oncology Research, Cleveland Clinic Case Western Reserve Univ., Cleveland, OH

Ilaria Stefania Pagani, PhD^1,2,3*, Vaidehi Krishnan, PhD^4*, John Ouyang, PhD^4*, Chung How Kok, BSc, PhD^5*, BeiJun Chen^4*, Elyse C Page, BSc(hons), PhD^1,2*, Phuong Dang^1*, Verity A Saunders^1*, Jane James^1*, Kelly Lim, MSc, BSc^6,7*, Naranie Shanmuganathan, MBBS, PhD, FRACP, FRCPA^2,3,7, Susan Branford, PhD^2,8, Charles Chuah, MBChB, MRCP(UK), FRCP(Edin)^9*, David T Yeung, MBBS, PhD, BSc, FRACP, FRCPA^3,5,10,11, Daniel Thomas, MD, PhD^5,12, Timothy P Hughes, MD, MBBS, FRACP, FRCPA^1,3,13, Sin Tiong Ong, MD¹⁴ and David M Ross, MD, PhD, FRACP, FRCPA^{3,6,7,8,11,15*}

¹Precision Cancer Medicine Theme, South Australian Health & Medical Research Institute (SAHMRI), Adelaide, Australia
²School of Medicine, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia
³Australasian Leukaemia and Lymphoma Group (ALLG), Melbourne, Australia
⁴Duke-NUS Medical School, Singapore, Singapore
⁵South Australian Health and Medical Research Institute, Adelaide, SA, Australia
⁶Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia
⁷South Australian Health and Medical Research Institute, Adelaide, Australia
⁸Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, Australia
⁹Department of Haematology, Singapore General Hospital, Singapore, Singapore
¹⁰University of Adelaide, Adelaide, SA, Australia
¹¹Department of Haematology and Bone Marrow Transplantation, Royal Adelaide Hospital and SA Pathology, Adelaide, Australia
¹²University of Adelaide, Stanford, CA
¹³South Australian Health and Medical Research Institute and University of Adelaide, Adelaide, SA, Australia
¹⁴Duke-NUS Medical School, Mission Viejo, CA
¹⁵Royal Adelaide Hospital and SA Pathology, Adelaide, SA, Australia

Ejike Ujoatu, BSc^1*, Sohini Mukhopadhyay, PhD^2*, Carmelo Gurnari, MD, PhD³, Valeria Visconte, PhD⁴, Jaroslaw Maciejewski⁵, Jayati Basu, PhD^2*, Babal K. Jha, PhD⁵, H. Leighton Grimes, PhD⁶, Stephen Sykes, PhD⁷ and Dietmar Kappes, PhD^8*

¹Lerner Research Institute, Case Western Reserve University, Montgomery, TX
²Lerner research Institute, Cleveland Clinic, Cleveland, OH
³Cleveland Clinic Foundation, Cleveland, OH
⁴Department of Translational Hematology & Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
⁵Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
⁶Division of Immunobiology, Cincinnati Children's Hospital, Cincinnati, OH
⁷Department of Pediatrics, Washington University School of Medicine, St Louis, MO
⁸Transgenic Animal Facility, Fox Chase Cancer Center, Philadelphia, PA

Yara Rodriguez^1,2*, Gabriela Alexe, PhD^1,3*, Audrey Taillon^1*, Constanze Schneider, PhD^1,3* and Kimberly Stegmaier, MD^1,4,5,6

¹Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA
²The Broad Institute of MIT and Harvard, Brookline, MA
³The Broad Institute of MIT and Harvard, Cambridge, MA
⁴Broad Institute of MIT and Harvard, Cambridge, MA
⁵Pediatric Oncology, Dana-Farber Cancer Institute, Boston
⁶Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA

Sanne Massaar^*, Emma Boertjes^*, Annelieke Zeilemaker^*, Jolinda Konijnenburg^*, Francois Kavelaars^*, Melissa Rijken^*, Tim Grob, MD^*, Jurjen Versluis, MD, PhD^*, Bob Lowenberg, MD, PhD, Peter J. M. Valk, PhD and Mathijs Arnoud Sanders, PhD^*

Department of Hematology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, Netherlands

Abdula Maher^1*, Severine Cathelin, PhD^2*, Dhanoop Manikoth Ayyathan, PhD^2*, Yitong Yang^3*, Alex Liu, BSc^3*, Mohsen Hosseini, PhD^2* and Steven M. Chan, MD, PhD^1,3,4

¹Institute of Medical Science, University of Toronto, Toronto, ON, Canada
²Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
³Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
⁴Princess Margaret Cancer Centre, Toronto, ON, Canada

Jane J. Xu, PhD^1,2, Viviana Scoca, PhD^1,2*, Yi Chen, MD, PhD^1,2*, John Pantazi, BA^1*, Sebastian Fernando^2*, Besmira Alija^1,2*, Varun S. Sudunagunta, BA^1,2,3 and Aaron D. Viny, MD, MS^1,2

¹Department of Medicine, Division of Hematology-Oncology, Columbia University Irving Medical Center, New York, NY
²Columbia Stem Cell Initiative, New York, NY
³Columbia University Vagelos College of Physicians and Surgeons, New York, NY

Max Petersen^1*, Kiayla Washington^2*, Anna Dorota Chorzalska, PhD^1* and Patrycja M Dubielecka, PhD^3,4,5

¹Brown University, Providence, RI
²Brown University, Providence
³Rhode Island Hospital and Warren Alpert Medical School At Brown University, Providence, RI
⁴Legorreta Cancer Center of Brown University, Providence, RI
⁵Pathobiology Graduate Program, Brown University, Providence, RI

Kellen B Gil, MD, MPH¹, Jamie Borg, BS^2*, Rosana Moreira Pereira, MS^3*, Anagha Inguva Sheth, PhD⁴, Jeremy Rahkola, BS^2*, William Showers, MS^5*, Angelo D'Alessandro, PhD⁶, Christine M. McMahon, MD⁷, Daniel A Pollyea, MD⁸, Austin E Gillen, PhD^9* and Maria L Amaya, MD, PhD³

¹Department of Medicine, University of Colorado Anschutz Medical Campus, Denver, CO
²Rocky Mountain Regional VA Medical Center, Aurora, CO
³University of Colorado, Aurora, CO
⁴University of Colorado, Denver, CO
⁵Division of Hematology, University of Colorado Department of Medicine, Aurora, CO
⁶Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO
⁷University of Colorado School of Medicine, Denver, CO
⁸Division of Hematology, University of Colorado, Denver, CO
⁹Division of Hematology, University of Colorado Anschutz Medical Campus, Aurora, CO

Geethu Emily Thomas, PhD, MSc, BSc^1*, Kazem Nouri, PhD^1*, Rose Hurren^1*, JongBok Lee^1*, Veronique Voisin, PhD^1*, Yongran Yan^1*, Neil Maclean^1*, Marcela Gronda^1*, Yulia Jitkova^1*, Taylor Barbieri^1*, Li Ma^1*, Xiaoming Wang^1*, Andrea Arruda^2*, Mark D. Minden, MD, PhD^2*, Li Zhang^3* and Aaron D Schimmer, MD⁴

¹University Health Network, Princess Margaret Cancer Centre, Toronto, ON, Canada
²Princess Margaret Cancer Centre / University Health Network, Toronto, ON, Canada
³University Health Network, Toronto General Hospital, Toronto, ON, Canada
⁴Princess Margaret Cancer Centre, Toronto, ON, Canada

Grace Egan, MD, PhD^1,2, Amit Kumar, PhD^2*, Veronique Voisin, PhD^2*, Rose Hurren^2*, Ali Chegini^2*, Dakai Ling^2*, Geethu Emily Thomas, PhD, MSc, BSc^2*, Youngran Yan^2*, Yue Feng², Suraj Bansal^3*, Andy G.X. Zeng, BSc³, Andrea Arruda^4*, John Edgar Dick³, Gary D Bader, PhD^5*, Mark D. Minden, MD, PhD^4* and Aaron D Schimmer, MD⁶

¹Hospital for Sick Children, Toronto, ON, Canada
²University Health Network, Princess Margaret Cancer Centre, Toronto, ON, Canada
³Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
⁴Princess Margaret Cancer Centre / University Health Network, Toronto, ON, Canada
⁵Terrence Donnelly Centre for Cellular and Biomedical Research, University of Toronto, Toronto, ON, Canada
⁶Princess Margaret Cancer Centre, Toronto, ON, Canada

Toshiya Hino^1*, Yosuke Masamoto, MD, PhD^1,2, Ken Morita, MD, PhD^1*, Hiroki Hayashida, MD, PhD^1* and Mineo Kurokawa, MD, PhD^1,2

¹Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
²Department of Cell Therapy and Transplantation Medicine, The University of Tokyo Hospital, Tokyo, Japan

Ka Lam Nelson Ng, PhD^1,2*, Lam Ng^1,3*, Stephen Lam, PhD, MBBS,^3*, Xingliang Liu, PhD^4*, Koon C. Chan^5,6*, Lichuan Zheng^1,7*, Chunxiao Zhang^5*, Rachel L. S. Tse^4*, Wing Lam^1,8*, Natalie Nok-Man Chan^1,5*, Cheuk Him Man, PhD^2*, Arthur K.L. Cheung, PhD^9*, Ho-Wan Ip^10*, Chun H. Au^11*, Edmond Ma, MD^12*, Chi T. Ng^13*, Ying Ni^14*, Run S. Li, PhD^14*, Guang Sheng Ling, PhD^4*, Suet Yi Leung, MD, PhD^6,9,10,15*, Asif Javed, PhD^4,15* and Anskar Y. H. Leung, MD, PhD^1,3,16

¹Centre for Oncology and Immunology, Hong Kong Science Park, Hong Kong, China
²Department of Medicine, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China
³Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
⁴School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong
⁵Department of Medicine, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong
⁶Centre for Oncology and Immunology, Hong Kong, Hong Kong
⁷Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
⁸Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong
⁹Centre for PanorOmic Sciences, The University of Hong Kong, Hong Kong, Hong Kong
¹⁰Department of Pathology, Queen Mary Hospital, Hong Kong, China
¹¹Hong Kong Genome Institute, Hong Kong, Hong Kong
¹²Department of Pathology, The Hong Kong Sanatorium and Hospital, Hong Kong, Hong Kong
¹³Clinical Trials Centre, The University of Hong Kong, Hong Kong, Hong Kong
¹⁴Department of Infectious Diseases and Public Health, City University of Hong Kong, Hong Kong, Hong Kong
¹⁵The Jockey Club Centre for Clinical Innovation and Discovery, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong
¹⁶The Jockey Club Centre for Clinical Innovation and Discovery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China

Christina Mayerhofer, MD^1,2*, Dan Li, PHD^1,2*, Trine A. Kristiansen, PhD^2,3*, Ernst Mayerhofer, MD^1*, Azeem Sharda^1,4*, Lingli He, PhD^4,5*, Michael Mazzola, PHD^1,2*, Giulia Schiroli, PhD^2,6*, Karin Gustafsson, PhD^3,5*, Sam Keyes^1,2*, Anna Kiem^1,2*, Eve Crompton^1,2*, Yanxin Xu, PhD^3*, Zhixun Dou, PhD^3*, Charles Vidoudez^7*, Peter G. Miller, MD, PhD¹, Nick Van Gastel, PhD^8* and David Scadden, MD^3,5

¹Massachusetts General Hospital, Boston
²Harvard Stem Cell Institute, Cambridge
³Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA
⁴Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA
⁵Harvard Stem Cell Institute, Cambridge, MA
⁶Massachusetts General Hospital, Boston, MA
⁷Harvard Center for Mass Spectrometry, Harvard University, Cambridge
⁸Laboratory of Cellular Metabolism and Microenvironment, De Duve Institute, UC Louvain, Brussels, Belgium

Arjun Dhir, MSc¹, Alexander Ethell^2*, Kevin Tur-Rodriguez^2*, Jim Persinger^2*, Michelle Becker^2*, Abu Rafay^3*, Vikas Kumar^2,4*, Sandipan Brahma^2*, Jordan Rowley, PhD^5* and R. Katherine Hyde, PhD¹

¹Department of Biochemistry and Molecular Biology, and Fred and Pamela Buffet Cancer Center, University of Nebraska Medical Center, Omaha, NE
²University of Nebraska Medical Center, Omaha, NE
³Northeastern University, Boston, MA
⁴UMass Chan Medical School, Worcester, MA
⁵Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE

Federica Valigi^1*, Fulya Mina Kücüktas, MSc^2*, Ilya Fliamer, PhD^3*, Zivojin Jevtic, PhD^2*, Hughes-Etienne Chatel-Soulet, PhD^2*, Amandine Bovay, PhD^2*, Rathick Sivalingam, MSc^2*, Andreja Baosic, MSc^2*, Florian Grebien, MSc, PhD^4*, Robert K. Slany, PhD⁵, Alexandar Tzankov, MD, PhD^6*, Sabine Juge^2*, Jonathan Seguin, PhD^2*, Menghan Wang, PhD^2*, Athimed El Taher, PhD^7*, Luca Giorgetti, PhD^3* and Juerg Schwaller, MD⁸

¹Department of Biomedicine, University Children's Hospital, Basel, AL, Switzerland
²Department of Biomedicine, University Children's Hospital, Basel, Switzerland
³Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
⁴Department of Medical Biochemistry, University of Veterinary Medicine, Vienna, Austria
⁵Department of Genetics, University Erlangen, Erlangen, Germany
⁶Institute for Pathology, University Hospital Basel, Basel, Switzerland
⁷Bioinformatics core, Department of Biomedicine, University of Basel & University Hospital Basel, Basel, Switzerland
⁸Department of Biomedicine, University Hospital, Basel, Switzerland

Rouxing Wang, PhD^1,2, Mohammed Alhusayan^3*, Bowen Xing^1,2*, Emma Hedgepeth^4*, Yan Liu, PhD⁵, Hamid Band, MD, PhD^6*, Laurence Eisenlohr^4*, Junwei Shi, PhD^3*, Irfan Asangani^3* and Wei Tong, PhD^2,7

¹Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA
²Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
³Department of Cancer Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
⁴Department of Pathology and Laboratoy Medicine, University of Pennsylvania, The Children's Hospital of Philadelphia, Philadelphia, PA
⁵Northwestern University, Chicago, IL
⁶Nebraska Medicine, University of Nebraska Medical Center, Omaha, NE
⁷Children's Hospital of Philadelphia, Philadelphia, PA

Austin C. Boucher, PhD^1*, Wojciech Rosikiewicz, PhD^2*, Ricky Tirtakusuma, PhD^3*, Anitria Cotton, MBA, BS^1*, Madeline Niederkorn, PhD¹, Elvin Wagenblast, PhD⁴, Paul G. Thomas, PhD^3*, Yubin Ge, PhD⁵, Jeffrey W. Taub, MD⁵, Jan-Henning Klusmann, MD⁶ and John D. Crispino, PhD¹

¹Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN
²Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN
³Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN
⁴Department of Oncological Sciences, Icahn School of Medicine/Mount Sinai, East York, ON, Canada
⁵Department of Oncology, Wayne State University School of Medicine, Detroit, MI
⁶Department of Pediatrics, Goethe University Frankfurt, Frankfurt, Hessen, Germany

Prajwal Boddu, MD¹, Rahul Roy, MSc^2*, Francis Baumgartner^3*, Stephan Hutter, PhD^4*, Torsten Haferlach, MD⁴ and Manoj Pillai, MD²

¹Yale University, East Lyme, CT
²Yale University, New Haven, CT
³Department of Hematology, Oncology and Cancer Immunology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Berlin, Germany
⁴MLL Munich Leukemia Laboratory, Munich, Germany

Xiaojing Yan, MD, PhD¹, Miao Chen^2*, Yuan Tao^2*, Sijing Kang^2*, Pengjie Yue^2* and Rui Ge^2*

¹Department of Hematology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China
²Department of Hematology, The First Affiliated Hospital of China Medical University, Shenyang, China

Chengcai Guo^1*, Yu Liu^1*, Qing Rao^2*, Runxia Gu, MD^2*, Shaowei Qiu, MD^1*, Min Wang^1* and Jianxiang Wang, MD³

¹State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
²State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Tianjin, China
³State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China