66th ASH Annual Meeting: 603. Lymphoid Oncogenesis: Basic: Poster II

Symposia: Lymphoid Oncogenesis: Basic Oral and Poster Abstracts
Poster

Research, Lymphoid Leukemias, ALL, Hodgkin lymphoma, Fundamental Science, Apoptosis, Adult, Lymphomas, Non-Hodgkin lymphoma, Drug development, Translational Research, CHIP, Assays, Genomics, Bioinformatics, Plasma Cell Disorders, B Cell lymphoma, Hematopoiesis, T Cell lymphoma, Pediatric, Diseases, Treatment Considerations, Lymphoid Malignancies, Non-Biological therapies, Metabolism, Computational biology, Young adult , Biological Processes, Pharmacology, Technology and Procedures, Gene editing, Molecular biology, Human, Pathogenesis, Omics technologies, Pathology

Halls G-H (San Diego Convention Center)

2735

Single-Cell Whole Genome Sequencing Reveals the Evolution and Migration of Lymphoma

Alexander S. Steemers^1,2^*, Vera M Poort, MSc^1,2^*, Ruben Van Boxtel, PhD^1,2^*, Friederike Meyer-Wentrup, MD, PhD³^*, Rico Hagelaar, MSc^1,2^* and Niels M Groenen⁴^*

¹Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
²Oncode Institute, Utrecht, Netherlands
³Pincess Máxima Centrum For Pediatric Oncology, Utrecht, NLD
⁴Prinses Maxima Centrum, Utrecht, Netherlands

2736

Ketogenic Regulation of Histone Modification By CDK4 Promotes Leukemogenesis

Hudan Liu, PhD

Wuhan University, Wuhan, China

2737

Proteomic Analysis of Thyroid Hormone-Induced Secretome in Cutaneous T Cell Lymphoma

María Mercedes Debernardi, BSc¹^*, Lucero Alvarado²^*, Ingrid Souza³^*, Graciela Alicia Cremaschi, PhD²^*, Alejandro Correa, Dr.³^* and Florencia Cayrol, PhD²

¹BIOMED-UCA-CONICET, Capital Federal, AL, Argentina
²BIOMED-UCA-CONICET, Buenos Aires, Argentina
³Instituto Carlos Chagas, Curitiba, Brazil

2738

Modeling the Initiation and Progression of Human MLL-Rearranged Precursor B Cell Acute Lymphoblastic Leukemia in Mice

Zhenhua Chen, PhD¹^*, Lu Yang, PhD²^*, Lillian Sau³^*, Zunsong Hu, PhD⁴, Meiling Chen³^*, Chengwu Zeng, PhD⁵^*, Chao Shen, PhD¹^*, Ying Qing, PhD³^*, Yuan Che³^*, Dong Wu, PhD³^*, Tingting Tang³^*, Zhaoxu Xu³^*, Xin He, MD⁶^*, Lianjun Zhang, PhD⁷^*, Pu Cheng⁸^*, Hengyou Weng, PhD⁹^*, Huilin Huang, PhD¹⁰^*, Zhaohui Gu, PhD⁴, Gang Xiao, PhD¹¹^*, Xiaolan Deng, PhD³^* and Jianjun Chen, PhD³

¹Department of Systems Biology, City of Hope, Arcadia, CA
²Department of Systems Biology, City of Hope National Medical Center, Duarte, CA
³Department of Systems Biology, City of Hope, Monrovia, CA
⁴City of Hope, Duarte, CA
⁵Department of Systems Biology, Beckman Research Institute, City of Hope, Monrovia, CA
⁶Department of Hematological Malignancies Translational Science, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA
⁷Department of Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA
⁸Zhejiang University School of Medicine, Hangzhou, China
⁹Guangzhou Laboratory, Guangzhou, China
¹⁰Sun Yat-sen University Cancer Center, Guangzhou, China
¹¹School of Medicine, Zhejiang University, Hangzhou, China

2739

Golcadomide-Mediated Degradation of Aiolos/Ikaros Synergizes with BET Inhibitors through Bidirectional Restructuring of the Directly Regulated Epigenetic Environment in DLBCL

Chih-Chao Hsu¹^*, Junfei Zhao¹^*, Ann Polonskaia¹^*, Chad C. Bjorklund¹^*, Maria Ortiz Estevez²^*, Anita K. Gandhi, PhD³ and Patrick R. Hagner, PhD¹^*

¹Bristol Myers Squibb, Summit, NJ
²Bristol Myers Squibb, Sevilla, Spain
³Hematology, Translational Medicine, Bristol Myers Squibb, Summit, NJ

2740

Defining Oncogenic Transcriptional Networks Regulated By LDB1 in T-Cell Acute Lymphoblastic Leukemia

Rahul S Bhansali, MD^1,2, Nicholas Aboreden, BS, MS¹^*, Siqing Wang, PhD¹^*, Cheryl A. Keller, PhD³^*, Belinda M. Giardine³^*, Ross C. Hardison, PhD³^* and Gerd A. Blobel, MD, PhD¹

¹Department of Pediatrics (Hematology), Children's Hospital of Philadelphia, Philadelphia, PA
²Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA
³Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA

2741

Elucidating the Role of IRF4 in Malignant Plasma Cell Regeneration at Single Cell Resolution

Marouscha De Vries, BSc¹^*, Silvia Vicenzi, PhD², Geena Ildefonso, PhD³^*, Brin Rosenthal, PhD⁴^* and Leslie A Crews, PhD⁵

¹Moores Cancer Center, University of California San Diego, San Diego, CA
²Moores Cancer Center, UNIVERSITY CALIFORNIA, SAN DIEGO, La Jolla, CA
³Center for Computational Biology and Bioinformatics (CCBB), University of California, San Diego, San Diego, CA
⁴Center for Computational Biology and Bioinformatics (CCBB), University of California San Diego, San Diego, CA
⁵Division of Regenerative Medicine, Department of Medicine, Moores Cancer Center and Sanford Stem Cell Institute, University of California San Diego, La Jolla, CA

2742

The First-in-Class PTPN2/1 Inhibitor Abbv-CLS-484 Disrupts Mitochondrial Renewal and Blocks Tfrc-Mediated PINK1-Prkn-Dependent Mitophagy to Exert Anti-Tumor Activities in ALK-Positive Anaplastic Large Cell Lymphoma

Jinhua Liang, PhD¹^*, Weiting Wang, MD²^*, Ziwen Duan, MD²^*, Tong-Yao Xing, MD²^*, Hao-Rui Shen²^*, Hua Yin³^*, Li Wang³^*, Jianyong Li, MD⁴ and Xu Wei, MD, PhD³

¹Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, NANJING, China
²Department of Hematology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China
³Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China
⁴First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China

2743

Regulation of Metabolism and Epitranscriptomic Modifications By RNA Binding Protein IGF2BP3

Gunjan Sharma¹^*, Matin Gutierrez²^*, Anthony E. Jones³^*, Zachary T. Neeb²^*, Amy Rios³^*, Amit K. Jaiswal, PhD¹, Michelle L. Thaxton¹^*, Tasha L. Lin⁴, Tiffany Tran, PhD^1,5^*, Lyna E.S. Kabbani²^*, Alexander J. Ritter²^*, Linsey Stiles^3,5^*, Johanna Ten Hoeve^6,7,8^*, Jeremy R. Sanford^2,9^*, Ajit S. Divakaruni³^* and Dinesh S. Rao, MD, PhD^1,10,11

¹Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA
²Department of Molecular, Cellular and Developmental Biology and Center for Molecular Biology of RNA, University of California, Santa Cruz, Santa Cruz, CA
³Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA
⁴Department of Medicine, Division of Hematology/Oncology, University of California, Los Angeles, Los Angeles, CA
⁵Department of Medicine, University of California, Los Angeles, Los Angeles, CA
⁶California Nanosystems Institute, University of California, Los Angeles, Los Angeles, CA
⁷UCLA Metabolomics Center, University of California, Los Angeles, Los Angeles, CA
⁸Crump Institute for Molecular Imaging,, University of California, Los Angeles, Los Angeles, CA
⁹Center for Biomolecular Science & Engineering, University of California, Santa Cruz, Santa Cruz, CA
¹⁰Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA
¹¹Broad Stem Cell Research Center, University of California, Los Angeles, Los Angeles, CA

2744

The Mutational Landscape of Extramedullary Multiple Myeloma Reveals Novel Biologic Insights and Potential Therapeutic Targets for Exploration

Saurabh Zanwar, MD, MBBS¹, Joseph Novak²^*, Michael D Howe³^*, Moritz Binder, MD¹, Wilson I. Gonsalves, MD¹, Esteban Braggio, PhD⁴, Vincent Rajkumar, MD¹^*, Dragan Jevremovic, M.D., Ph.D⁵^*, Surendra Dasari, PhD⁶^* and Shaji Kumar, MD¹

¹Division of Hematology, Mayo Clinic, Rochester, MN
²Mayo Clinic, Hematology Data Science, Rochester, MN
³Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN
⁴Division of Hematology and Oncology, Mayo Clinic, Scottsdale, AZ
⁵Mayo Clinic, Rochester, MN
⁶Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN

2745

Characterizing and Targeting Follicular Lymphoma's Common Progenitor Cells

Oscar Atkins¹^*, Lingling Zhang¹^*, Miu Shing Hung¹^*, Christian Reinhardt²^* and Dinis Calado, PhD³^*

¹The Francis Crick Institute, Immunity and Cancer Laboratory, London, United Kingdom
²Essen University Hospital, Essen, Germany
³The Francis Crick Institute, London, United Kingdom

2746

Roles of TET2 Loss in B Cell Transformation

Sarah Spoeck^*, Nadine Kinz^* and Verena Labi, PhD^*

Innsbruck Medical University, Innsbruck, Tirol, Austria

2747

Cyclin D1 Overexpression in Mantle Cell Lymphoma Causes Cellular Dependence on Microhomology-Mediated End-Joining

Jithma P Abeykoon, MD¹, Shuhei Asada, MD, PhD², Guangli Zu, M.D.²^*, Yuna Hirohashi³^*, Divya Iyer, Ph.D³^*, Kalindi Parmar, PhD⁴^*, Lige Jiang³^*, Sirisha Mukkavalli, Ph.D³^*, Dongni Yi, MD³^*, Michelle Manske, MS, BS⁵^*, Xiaosheng Wu, MD¹^*, Kimberly Gwin⁵^*, Thomas E. Witzig, MD⁶, Geoffrey I Shapiro, MD³^* and Alan D. D'Andrea, MD²^*

¹Division of Hematology, Mayo Clinic, Rochester, MN
²Dana-Farber Cancer Institute, Boston, MA
³Dana-Farber Cancer Institute, Boston
⁴Dana-Farber Cancer Inst. Harvard Med. School, Boston, Boston, MA
⁵Mayo Clinic, Rochester, MN
⁶Division of Hematology, Mayo Clinic, Stabile 628, Rochester, MN

2748

Metabolic Signature of Oxidative Phosphorylation Deficiency with Activated Nucleotide Biosynthesis in Early T-Cell Precursor Acute Lymphoblastic Leukemia

Yinghui Zhu¹^*, Bowen Wu²^*, Tianyi Chen¹^*, Miaomiao Liu¹^*, Shangyu Hou¹^*, Xuemei Wang¹^*, Yiyi Yao³^*, Tao Zeng⁴^*, Jinyan Huang⁵^*, Jie Jin, M.D.² and Huafeng Wang²^*

¹State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, Shanghai, China
²Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Hangzhou, China
³Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
⁴Biomedical big data center, the First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, Hangzhou, China
⁵Biomedical big data center, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

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^*signifies non-member of ASH