Valeria Santini^1*, Amer M. Zeidan, MBBS, MHS², Uwe Platzbecker, MD³, Rami S. Komrokji, MD⁴, Guillermo Garcia-Manero, MD⁵, Dimana Miteva^6*, Aylin Yucel^7*, Veronika Pozharskaya^7*, Shelonitda Rose⁷, Yinzhi Lai^7*, Ana Carolina Giuseppi^7*, David Valcárcel Ferreiras^8*, Pierre Fenaux, MD⁹, Jake Shortt^10* and Matteo Giovanni Della Porta, MD^11*

¹University of Florence Medical School, Florence, Italy
²Department of Internal Medicine, Section of Hematology, Yale University, New Haven, CT
³University Hospital Leipzig, Leipzig, Germany
⁴Moffitt Cancer Center, Tampa, FL
⁵Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁶Bristol Myers Squibb, Boudry, Switzerland
⁷Bristol Myers Squibb, Princeton, NJ
⁸Hospital Vall d'Hebron, Barcelona, Spain
⁹Service d'Hématologie Séniors, Hôpital Saint-Louis, Université Paris 7, Paris, France
¹⁰Monash University and Monash Health, Melbourne, VIC, Australia
¹¹Humanitas University, Milan, Italy

Sandra Huber, PhD¹, Stephan Hutter, PhD^1*, Constance Regina Baer, PhD¹, Manja Meggendorfer, PhD², Gregor Hoermann, MD, PhD², Wolfgang Kern, MD¹, Torsten Haferlach, MD¹ and Claudia Haferlach, MD¹

¹MLL Munich Leukemia Laboratory, Munich, Germany
²MLL Munich Leukemia Laboratory, Munich, Bavaria, Germany

Clifford M. Csizmar, MD, PhD¹, Anuya A. Natu, MBBS^1*, Mark Gurney, MB, BCh, BAO^1*, Rashmi Kanagal-Shamanna, MD², Sanam Loghavi, MD³, Alexandre Bazinet, MD^4*, Kelly S. Chien, MD⁵, Danielle Hammond, MD⁶, Terra L. Lasho, PhD¹, Christy Finke, BS^1*, Aref Al-Kali, MD¹, Hassan B Alkhateeb, MD^1*, Naseema Gangat, MBBS¹, Abhishek A. Mangaonkar, MBBS⁷, Antoine N. Saliba, MD¹, Ayalew Tefferi, MD¹, Guillermo Garcia-Manero, MD⁶, Hagop Kantarjian, MD⁶, Guillermo Montalban-Bravo, MD⁶ and Mrinal M. Patnaik, MD, MBBS¹

¹Division of Hematology, Mayo Clinic, Rochester, MN
²Department of Hematopathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX
³Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston
⁵Department of Leukemia, MD Anderson, Houston, TX
⁶Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁷Mayo Clinic, Rochester, MN

Mikkael A. Sekeres, MD¹, Hetty E. Carraway, MD, MBA², Richard M Stone, MD³, Yazan F Madanat, MD⁴, Rami S. Komrokji, MD⁵, Sangeetha Venugopal, MD, MS⁶, Namrata S. Chandhok, MD⁷, Terrence Bradley, MD⁸, Justin Taylor, MD⁹, Anastasia Santiago, NP⁶, Alessia Zoso, PhD^10*, Justin M. Watts, MD¹¹ and Amy E. DeZern, MD, MHS¹²

¹Division of Hematology, Sylvester Cancer Center, University of Miami, Miami, FL
²Department of Hematology and Medical Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH
³Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
⁴Division of Hematology/Oncology, Department of Internal Medicine, University of Texas Southwestern, Dallas, TX
⁵Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
⁶Sylvester Cancer Center, University of Miami, Miami, FL
⁷Sylvester Comprehensive Cancer Center, University of Miami-Miller School of Medicine, Miami, FL
⁸University of Miami Sylvester Comprehensive Cancer Center, Miami, FL
⁹Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL
¹⁰University of Miami Sylvester Cancer Center, Miami, FL
¹¹Sylvester Cancer Center, University of Miami Miller School of Medicine, Miami, FL
¹²Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD

Freya Schulze, MD^1*, Waldemar Hahn, MSc^2,3*, Katja Sockel, MD^1*, Susann Winter, PhD^1*, Markus Wolfien, PhD^2,3*, Martin Bornhaeuser, MD^4,5,6, Jan Moritz Middeke, MD^1,7* and Jan-Niklas Eckardt^1,7*

¹Department of Internal Medicine I, University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany
²Center for Scalable Data Analytics and Artificial Intelligence (ScaDS.AI) Dresden/Leipzig, Dresden, Germany
³Institute for Medical Informatics and Biometry, TUD Dresden University of Technology, Dresden, Germany
⁴Department of Internal Medicine I, Universitatsklinikum Cad GustavCarus an der Technischen Universltat Dresden, Dresden, Ferscherstrabo 74, Germany
⁵National Center for Tumor Disease (NCT), Dresden, Germany
⁶German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), Dresden, Germany
⁷Else Kroener Fresenius Center for Digital Health, TUD Dresden University of Technology, Dresden, Germany

Talha Badar, MD¹, Kashish J. Shah, MBBS^2*, Mobachir El Kettani, MD^2*, James M. Foran, MD³, Mohamed A. Kharfan-Dabaja, MD, MBA⁴, Hemant S. Murthy, MD², Naseema Gangat, MBBS⁵, Aref Al-Kali, MD⁶, Mithun V Shah, M.D., Ph.D.⁵, Hassan B Alkhateeb, MD^5*, Antoine N. Saliba, MD⁵, William J. Hogan, MD⁵, Cecilia Y. Arana Yi, MD⁷, Lisa Sproat, MD⁸, Jeanne Palmer, MD⁹, Mark R. Litzow, MD⁵ and Mrinal M. Patnaik, MD, MBBS¹⁰

¹Division of Hematology-Oncology, Blood and Marrow Transplantation Program, Mayo Clinic, Jacksonville, FL
²Mayo Clinic, Jacksonville, FL
³Division of Hematology & Medical Oncology, Mayo Clinic, Jacksonville, FL
⁴Department of Hematology/Oncology, Mayo Clinic, Jacksonville, FL
⁵Division of Hematology, Mayo Clinic, Rochester, MN
⁶Mayo Clinic, Rochester
⁷Division of Hematology/Oncology, Mayo Clinic, Scottsdale, AZ
⁸Mayo Clinic, Phoenix, AZ
⁹Mayo Clinic - Arizona, Scottsdale, AZ
¹⁰Mayo Clinic, Rochester, MN

Paula Piñero, PhD^1*, Rocio Gonzalez^2*, Vanesa Diaz^3*, Elena Marin^4*, Marina Gonzalez^4*, Javier Lopez^4*, Pablo Manresa^3*, M. Carmen Garcia Hernandez^5* and Fabian Tarin^3*

¹ISABIAL, ALICANTE, AL, Spain
²ISABIAL, ALICANTE, Spain
³Hospital Universitario Dr. Balmis, ALICANTE, Spain
⁴PINTOR BAEZA 12, Hospital Universitario Dr. Balmis, ALICANTE, Spain
⁵Hospital Universitario Dr. Balmis, Alicante, Spain

Aristoteles Giagounidis, MD¹, Monteserrat Arnan, MD, PhD^2*, Lynette C.Y. Chee, MBBS, PhD, FRACP, FRCPA³, Thomas Cluzeau, MD, PhD⁴, Maria Diez-Campelo, MD, PhD^5*, Devendra Hiwase, MD, MBBS, PhD, FRACP, FRCPA⁶, David M Ross, MD, PhD, FRACP, FRCPA^7*, Mikkael A. Sekeres, MD⁸, Shuhying Tan, FRACP, FRCPA, MBBS^9*, David Valcarcel, MD, PhD¹⁰, Rena Buckstein, MD, FRCPC¹¹, Bhavna Patel-Shah^12*, Ming Yang, PhD^12*, Ying Jiang, PhD, MBA^12*, Jiani Yin, PhD^12*, Suresh Bobba^12*, Montagu Hankin, MSc^12*, Chris Materna, MSc^12*, Christine Graham, PhD^12*, Sanjay Thamake, PhD, MBA^12*, Christopher Rovaldi, MSc^12*, Dena Grayson, MD, PhD^12* and Jen L. Salstrom, MD, PhD¹²

¹Clinic for Hematology, Oncology and Palliative Care Marien Hospital Düsseldorf, Dusseldorf, Germany
²Institut Català d'Oncologia -Hospital Duran i Reynalshe, Ashby De La Zouch, ESP
³Department of Clinical Haematology and Bone Marrow Transplant Service, The Royal Melbourne Hospital, Parkville, Australia
⁴Department for Clinical Hematology, Nice University Hospital, Nice, Provence Alpes Cote d'Azur, France
⁵Hospital Clínico Universitario de Salamanca, Salamanca, Spain
⁶Royal Adelaide Hospital, Adelaide, SA, Australia
⁷Royal Adelaide Hospital and SA Pathology, Adelaide, SA, Australia
⁸Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL
⁹Department of Haematology, St Vincent’s Hospital, Melbourne, Australia
¹⁰Department of Hematology and Oncology, Hospital Universitario Vall d'Hebron, Barcelona, Spain
¹¹Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
¹²Kero's Therapeutics, Lexington

Mathieu Meunier^1*, Sylvain Thepot, MD^2*, Stanislas Nimubona, MD^3*, Mélanie Véloso^4*, Thibaud Lefebvre^5*, Karim Zoubida^6*, Martine Ropert-Bouchet^7*, Frederic Garban, Md, PhD^8*, Shanti Ame, MD, PhD^9*, Abdesssamia Gandoul^10*, Claire Reynes^11*, Celia Salanoubat^12*, Sébastien Maury, MD, PhD^13*, Kamel Laribi, MD^14*, Pirayeh Eftekhari^15*, Jacques Delaunay^16*, Geoffroy Venton^17*, Clemence Santana^18*, Stephane Cheze, MD^19*, Sophie Dimicoli-Salazar, MD^20*, Mathieu Molimard^21*, Valérie Rolland-Neyret^22*, Sandra David-Tchouda^23,24,25* and Sophie Park, MD, PhD²⁶

¹Department of Hematology CHU Grenoble Alpes, Grenoble, France
²Department of Clinical Hematology, Angers University Hospital, ANGERS, NA, France
³Hopital Pontchaillou, Rennes, France
⁴Data Engineering Unit, Public Health Department,, Univ. Grenoble Alpes and Grenoble Alpes University Hospital,, Grenoble, France
⁵Centre Français des Porphyries, INSERM U1149,, Hôpital Louis Mourier, APHP, Colombes, France
⁶Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity),INSERM UMR1291 - CNRS UMR5051, Université Toulouse III, CHU PURPAN, Toulouse, France
⁷Laboratoire de biochimie spécialisée, CHU de Rennes, Rennes,, France
⁸Hematology Department, CHU Grenobles Alpes, Grenoble, France
⁹Department of hematology, Institut de Cancérologie de Strasbourg, Strasbourg, France
¹⁰Hematology Department, CHU Grenoble Alpes, Grenoble, France
¹¹Hematology Unit, Annecy Genevois Hospital Center, Annecy, France
¹²Hématologie clinique, Centre Hospitalier Sud Francilien, Corbeil-Essonnes, France
¹³Hematology Department, Hôpital Henri Mondor, Créteil, France
¹⁴Hematology Department, Le Mans Hospital, Le Mans, France
¹⁵Department of Hematology, AP-HP. Hôpital Bicêtre, Paris, France
¹⁶Hôpital privé du confluent, Nantes, France
¹⁷Hôpital de la Timone, Service Hématologie et Thérapie Cellulaire, Centre d’Essais Précoces en Cancérologie de Marseille (CEPCM), Marseille, France
¹⁸département d'hématologie, CH de Valence, Valence, France
¹⁹Institut d'Hématologie de Basse-Normandie, Centre Hospitalier de Caen Normandie, Caen, France
²⁰Hôpital Haut-Lévêque, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France
²¹Department of Medical Pharmacology, CHU de Bordeaux, Bordeaux, France
²²Department of Hematology, CHU Grenoble Alpes, Grenoble, France
²³Data Engineering Unit, Public Health Department,, Univ. Grenoble Alpes and Grenoble Alpes University Hospital, Grenoble, France
²⁴Clinical and economic unit, Public Health Department, Grenoble Alpes University Hospital, Grenoble, France
²⁵TIMC-Imag UMR 5525, Univ. Grenoble Alpes, Grenoble, France
²⁶Hematology Department, CHU Grenoble, Grenoble Cedex 9, France

Ayalew Tefferi, MD¹, Saubia Fathima^2*, Ali Khalid Alsugair^3*, Clifford M. Csizmar, MD, PhD⁴, Mark Gurney, MB, BCh, BAO^1*, Terra L. Lasho, PhD¹, Christy Finke, BS^1*, Abhishek A. Mangaonkar, MBBS², Aref Al-Kali, MD³, Hassan B Alkhateeb, MD^1*, Kaaren K. Reichard, MD⁵, Animesh D. Pardanani, MBBS, PhD⁴, Naseema Gangat, MBBS¹ and Mrinal M. Patnaik, MD, MBBS²

¹Division of Hematology, Mayo Clinic, Rochester, MN
²Mayo Clinic, Rochester, MN
³Mayo Clinic, Rochester
⁴Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN
⁵Department of Pathology, Mayo Clinic, Rochester, MN

Daniel A Pollyea, MD¹, Brett M Stevens, PhD, BS^2*, Diana Abbott, PhD³, Maria L Amaya, MD, PhD^4,5, Jonathan Gutman, MD⁶, Andrew Kent, MD, PhD⁶, Christine M. McMahon, MD⁷, Marc Schwartz, MD¹, Clayton Smith, MD⁸, Jessica Dell-Martin^9*, Connor Sohalski^4*, Alexandra Ellis^10*, Mary Haag^10*, Jeffrey Schowinsky^4*, Zenggang Pan, MD, PhD^11*, Sweta B Patel, PhD^12*, Monica Ransom, PhD^12*, Austin E Gillen, PhD^2*, Eric M. Pietras, PhD¹³ and Craig T Jordan, PhD¹⁴

¹Division of Hematology, University of Colorado, Denver, CO
²Division of Hematology, University of Colorado Anschutz Medical Campus, Aurora, CO
³Center for Innovative Design and Analysis (CIDA), Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado, Anschutz Medical Campus, Aurora, CO
⁴University of Colorado, Aurora, CO
⁵Rocky Mountain Regional VA Medical Center, Aurora, CO
⁶Division of Hematology, University of Colorado, Aurora, CO
⁷University of Colorado School of Medicine, Denver, CO
⁸CU Innovations, University of Colorado, Aurora, CO
⁹University of Colorado Anschutz Medical Campus, Aurora, CO
¹⁰University of Colorado, Aurora
¹¹Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO
¹²University of Colorado School of Medicine, Aurora, CO
¹³Division of Hematology, Department of Medicine, University of Colorado, Aurora, CO
¹⁴Universit of Colorado Anschutz Medical Campus, Aurora, CO

Nina Kim^*, Xin Wang, PhD^*, Ilynn Bulatao, MD, PhD^*, Jonathon Vallejo, PhD^*, Yuan Li Shen, PhD^*, Dianne D. Pulte, MD, Marc R. Theoret, MD^*, R. Angelo De Claro, MD^* and Kelly J. Norsworthy, MD^*

U.S. Food and Drug Administration, Silver Spring, MD

Curtis A Lachowiez, MD¹, Georgios Asimomitis^2*, Elsa Bernard, PhD^3*, Yanis Tazi, MSc, BSc^4*, Maria Creignou, MD^5*, Ulrich Germing, MD^6*, Norbert Gattermann, MD⁷, Amanda Gilkes, PhD^8*, Ian Thomas^9*, Lars Bullinger¹⁰, Konstanze Döhner, MD¹¹, Luca Malcovati, MD¹², Nigel H. Russell, MD¹³, Mario Cazzola, MD¹⁴, Hartmut Döhner, MD¹¹, Brian J P Huntly, MD^15*, Robert P Hasserjian, MD¹⁶, Eva Hellstrom Lindberg, MD, PhD^17*, Sanam Loghavi, MD¹⁸ and Elli Papaemmanuil¹⁹

¹Knight Cancer Institute, Oregon Health & Science University, Portland, OR
²Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, Memorial Sloan Kettering Cancer Center, New York, NY
³Gustave Roussy, université Paris-Saclay, Inserm U981, Villejuif, France
⁴Memorial Sloan Kettering Cancer Center, New York
⁵Phase 1 Unit, Center for Clinical Cancer Studies, Karolinska University Hospital, Stockholm, Sweden
⁶Department of Hematology, Oncology and Clinical Immunology, University Medical Center Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany
⁷Heinrich-Heine-Universitat, Dusseldorf, Germany
⁸Department of Haematology, Division of Cancer & Genetics School of Medicine, Cardiff University, Cardiff, United Kingdom
⁹Centre for Trials Research, Cardiff University, Cardiff, United Kingdom
¹⁰Department of Hematology, Oncology, and Cancer Immunology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
¹¹Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany
¹²Department of Molecular Medicine, University of Pavia, Piazzale Golgi 2, Italy
¹³Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
¹⁴University of Pavia, Pavia, Italy
¹⁵Department of Haematology, University of Cambridge, Cambridge, United Kingdom
¹⁶Department of Pathology, Massachusetts General Hospital, Boston, MA
¹⁷Center for Hematology and Regenerative Medicine (HERM), Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden
¹⁸Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
¹⁹Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY

Amy E. DeZern, MD, MHS¹, Michael Otterstatter, PhD^2*, Nancy Gillis, PhD³, Gregory A Abel, MD, MPH⁴, Tareq Al Baghdadi, MD^5*, Rafael Bejar, MD, PhD⁶, H. Joachim Deeg, MD⁷, James M. Foran, MD⁸, Rami S. Komrokji, MD⁹, R. Coleman Lindsley, MD⁴, Jane Jijun Liu^10*, Lynn C. Moscinski, MD¹¹, Wael Saber, MD, MS¹², Ling Zhang, MD¹³, Christine Borchert, BSc^2*, Eric Padron, MD⁹, Seth Sherman, PhD^2*, Nancy DiFronzo, PhD^14*, Matthew J. Walter, MD¹⁵ and Mikkael A. Sekeres, MD¹⁶

¹The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD
²The Emmes Company, LLC, Rockville, MD
³Department of Cancer Epidemiology, Moffitt Cancer Center and Research Institute, Tampa, FL
⁴Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
⁵IHA Hematology Oncology Consultants, Ypsilanti, MI
⁶University of California, San Diego, La Jolla, CA
⁷Fred Hutchinson Cancer Research Center, Seattle, WA
⁸Division of Hematology & Medical Oncology, Mayo Clinic, Jacksonville, FL
⁹Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
¹⁰Illinois CancerCare, Peoria, IL
¹¹Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
¹²Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI
¹³Department of Pathology and Laboratory Medicine, H. Lee Moffitt Cancer and Research Institute, Tampa, FL
¹⁴Division of Blood Diseases & Resources, The National Heart, Lung, and Blood Institute, Bethesda, MD
¹⁵Washington University In St. Louis, Saint Louis, MO
¹⁶Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL

Guillermo Garcia-Manero, MD¹, Matteo Giovanni Della Porta, MD^2,3*, Valeria Santini^4*, Amer M. Zeidan, MBBS, MHS⁵, Rami S. Komrokji, MD⁶, Pierre Fenaux, MD⁷, David Valcárcel⁸, Jake Shortt^9*, Mrudula B. Glassberg^10*, Aylin Yucel^11*, Yinzhi Lai^11*, Dimana Miteva^12*, Shelonitda Rose¹¹, Ahmed Hnoosh^13* and Uwe Platzbecker, MD¹⁴

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Cancer Center IRCCS Humanitas Research Hospital, Milan, Italy
³Department of Biomedical Sciences, Humanitas University, Milan, Italy
⁴MDS Unit, Hematology, University of Florence, DMSC, AOUC, Florence, Italy
⁵Department of Internal Medicine, Yale School of Medicine and Yale Cancer Center, Yale University, New Haven, CT
⁶Moffitt Cancer Center, Tampa, FL
⁷Service d'Hématologie Séniors, Hôpital Saint-Louis, Université Paris 7, Paris, France
⁸Vall d’Hebron Institute of Oncology (VHIO), Department of Hematology, Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona, Barcelona, Spain
⁹Monash University and Monash Health, Melbourne, VIC, Australia
¹⁰Bristol Myers Squibb, Madison, NJ
¹¹Bristol Myers Squibb, Princeton, NJ
¹²Celgene International Sàrl, a Bristol-Myers Squibb Company, Boudry, Switzerland
¹³Bristol Myers Squibb, Uxbridge, United Kingdom
¹⁴Medical Clinic and Policlinic 1, Hematology and Cellular Therapy, University Hospital Leipzig, Leipzig, Germany

Andrew M. Brunner, MD¹, Yiwen Liu, MS^2*, Jacqueline S. Garcia, MD³, Lourdes Mendez, MD^4*, Catherine Gutierrez, MD, PhD⁵, Philip C. Amrein, MD⁶, Rupa Narayan, MD⁶, Rahul Vedula, MD⁷, Donna S. Neuberg, ScD⁸, Marcio Andrade-Campos^9*, Simon Smith, PhD, BSc^10*, Richard M Stone, MD³, Amir T. Fathi, MD¹¹, Matthew J. Walter, MD¹², Timothy Aaron Graubert, MD⁶ and Meagan Jacoby, MD¹³

¹Division of Hematology/Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
²Data Science, Dana-Farber Cancer Institute, Boston, MA
³Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
⁴Department of Internal Medicine, Section of Hematology, Yale School of Medicine - Yale Cancer Center, New Haven, CT
⁵Massachusetts General Hospital, Boston, MA
⁶Division of Hematology/Oncology, Massachusetts General Hospital, Boston, MA
⁷Medical Oncology, Dana-Farber Cancer Institute, Stoneham, MA
⁸Department of Data Science, Dana-Farber Cancer Institute, Boston, MA
⁹Astrazeneca, Cambridge, GBR
¹⁰AstraZeneca, Royston, GBR
¹¹Center for Leukemia, Massachusetts General Hospital Cancer Center, Boston, MA
¹²Washington University In St. Louis, Saint Louis, MO
¹³Washington University-School of Medicine, Richmond Heights, MO

Wei-Bin Wu^1*, Ya-Wen Luo^2*, Siqi Li, M.D.^3*, Lanping Xu^4*, Yu Wang^5*, Xiaohui Zhang, MD⁵, Yuqian Sun^6*, Feifei Tang^7*, Xiaodong Mo^8*, Kai-Yan Liu, MD, PhD⁹, Xiao-Su Zhao^10*, Xiang-Yu Zhao^1*, He-Bing Chen^2*, Ying-Jun Chang^11* and Xiaojun Huang¹²

¹Peking University People's Hospital, National Clinical Research Center For Hemat, Beijing, CHN
²Academy of Military Medical Sciences, Beijing, China
³Department of Hematology, Peking University Institute of Hematology, Peking University People’s Hospital, Beijing, China
⁴Peking University People’s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing, China
⁵Peking University People's Hospital, Beijing, China
⁶National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China
⁷Peking University People’s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, AL, China
⁸Peking University Institute of Hematology, Peking University Peoples’ Hospital, Beijing, China
⁹Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China
¹⁰Peking University People’s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China
¹¹Peking University People’S Hospital & Peking University Institute of Hema, Beijing, China
¹²Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing, China

Beatrice Drexler, MD^1,2*, Stephan Schwarz-Furlan^3*, Irith Baumann^4*, Martina Rudelius, MD^5*, Peter Noellke, MPH^6*, Dirk Lebrecht^6*, Senthilkumar Ramamoorthy, PhD^6*, Natalia Rotari^2*, Axel Karow^7*, Shinsuke Hirabayashi, M.D., Ph.D.^8*, Marcin Wlodarski, MD, PhD^2,9, Fabian Beier, MD^10*, Yvonne Lisa Behrens^11*, Gudrun Göhring^12*, Reinhard Kalb^13*, Brigitte Strahm, PhD^2*, Miriam Erlacher¹⁴, Charlotte Marie Niemeyer, MD¹⁵ and Ayami Yoshimi^2*

¹Department of Hematology, University Hospital Basel, Basel, Switzerland
²Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, University Medical Center Freiburg, Germany, Freiburg, Germany
³Institute of Pathology, Klinikum Kaufbeuren-Ravensburg, Kaufbeuren, Germany
⁴Klinikum Kaufbeuren-Ravensburg, Kaufbeuren, Germany
⁵Institute of Pathology, Hospital of the Ludwig-Maximilians-University (LMU), Munich, Germany
⁶Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, University Medical Center Freiburg, Germany, Freiburg, DEU
⁷Friedrich-alexander-universitäT Erlangen-nüRnberg (FAU), Erlangen, DEU
⁸Department of Pediatrics, Faculty of Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
⁹St. Jude Children's Research Hospital, Memphis, TN
¹⁰University Hospital Aachen, Aachen, NRW, Germany
¹¹Hannover Medical School, Hannover, DEU
¹²Amedes Genetics, Hannover Medical School, Hannover, Germany
¹³University of Wuerzburg, Wuerzburg, DEU
¹⁴Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany
¹⁵Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, University Medical Center Freiburg, Germany, Freiburg, Baden Württemberg, Germany

Claudia Haferlach, MD¹, Sandra Huber, PhD¹, Stephan Hutter, PhD^1*, Constance Regina Baer, PhD¹, Manja Meggendorfer, PhD², Gregor Hoermann, MD, PhD², Wolfgang Kern, MD¹ and Torsten Haferlach, MD¹

¹MLL Munich Leukemia Laboratory, Munich, Germany
²MLL Munich Leukemia Laboratory, Munich, Bavaria, Germany

Danielle Hammond, MD¹, Koji Sasaki, MD¹, Koichi Takahashi, MD, PhD¹, Elizabeth J. Shpall, MD², Uday Popat, MD², Betul Oran, MD, MS², Gheath Al-Atrash, MD, PhD^2*, Krina K. Patel, MD, MSc³, Jason R. Westin, MD⁴, Sattva S. Neelapu, MD⁵, Yesid Alvarado Valero, MD¹, Kelly S. Chien, MD⁶, Naval Daver, MD⁷, Guillermo Montalban-Bravo, MD¹, Abhishek Maiti, MBBS¹, Musa Yilmaz, MD^1*, Elias Jabbour, MD⁸, Naveen Pemmaraju, MD¹, Mahesh Swaminathan, MD¹, Jo Ishizawa, MD, PhD⁹, Nitin Jain, MD¹, Alessandra Ferrajoli, MD¹, Farhad Ravandi, MBBS¹⁰, Steven M. Kornblau, MD¹, Gautam Borthakur, MD⁹, Guillermo Garcia-Manero, MD¹, Hagop M. Kantarjian, MD¹, Patrick K. Reville, MD, MPH¹ and Hussein A. Abbas, MD, PhD¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX
³M.D. Anderson Cancer Center, MD Anderson Cancer Center, Houston, TX
⁴The University of Texas M D Anderson Cancer Center, Houston, TX
⁵Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX
⁶Department of Leukemia, MD Anderson, Houston, TX
⁷MD Anderson Cancer Center, Houston, TX
⁸Department of Leukemia, University of Texas M.D. Anderson Cancer Ctr., Houston, TX
⁹Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
¹⁰Department of Leukemia, University of Texas- MD Anderson Cancer Center, Houston, TX

Elena Bechtold Javier, MD^1*, Helena Pomares^1*, Sandra Castaño-Díez, MD^2*, Guillermo Ramil López, MD^3*, Ivan Martín, MD^4*, Ana Perez Gonzalez, MD^5*, Blanca Xicoy, MD^6*, Joan Bargay^7*, Ferran Vall-Llovera Calmet, MD^8*, Tzu Hua Chen, MD^9*, Jordi Vila Bou^10*, Clara Maluquer Artigal, MD^1*, Ines Zugasti^2*, Mercedes Galiano^1*, Shiomara Quiñones, MD^1*, Mar Tormo, MD¹¹, Guadalupe Onate, MD, PhD^3*, Esther Alonso^12*, Neus Ruiz Xiville, PhD^13*, Lurdes Zamora, PhD^14*, Jordi Esteve, MD, PhD², Marina Diaz Beya, MD^2*, Anna Sureda Balari, MD, PhD¹ and Montserrat Arnan, MD, PhD^1*

¹Clinical Hematology Department, ICO-Hospitalet, Hospital Durán i Reynals. IDIBELL, Barcelona., Barcelona, Spain
²Hematology Department, Hospital Clínic de Barcelona, Barcelona, Spain
³Hematology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
⁴Department of Hematology and Medical Oncology, Hospital Clínico Universitario INCLIVA Biomedical Research Institute, Valencia, Spain, Valencia, Spain
⁵Department of Hematology, Experimental Hematology Unit, Vall d’Hebron Institute of Oncology (VHIO), University Hospital Vall d’Hebron, Barcelona, Barcelona, Spain
⁶Hematology Service, ICO-Hospital Germans Trias i Pujol, Institut de Recerca contra la Leucèmia Josep Carreras (IJC), Universitat Autònoma de Barcelona, Badalona, Spain
⁷Hematology Department, Hospital Universitario Son Llàtzer. IdIsBa., Palma de Mallorca, Spain
⁸Hematology Department, Hospital La Mutua. Tarrassa, Terrassa, ESP
⁹Hematology and Medical Oncology Department, University Hospital Morales Meseguer. CRH-IMIB, Murcia, Spain
¹⁰Institut Català d’Oncologia - Hospital Universitari de Girona Dr. Josep Trueta, Girona, ESP
¹¹Department of Hematology and Medical Oncology,, Hospital Clínico Universitario de Valencia. INCLIVA Biomedical Research Institute, Valencia, Spain
¹²Hospital De Bellvitge, L'Hospitalet De Llobregat, Ba, ESP
¹³Hematology Laboratory, ICO-Badalona, Hospital Germans Trias i Pujol., Badalona, Spain
¹⁴Institut Català d’Oncologia-Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain

Marie Sebert, MD, PhD^1*, Sylvie Chevret^2*, Sophie Dimicoli-Salazar, MD^3*, Thomas Cluzeau, MD, PhD^4*, Odile Rauzy, MD^5*, Aspasia Stamatoulas Bastard, MD^6*, Kamel Laribi^7*, Gaelle Fossard^8*, Sylvain Thépot, MD^9,10*, Silke Gloaguen, MSc^11*, Kristell Desseaux^12*, Norbert Vey, MD¹³, Pierre Peterlin^14*, Anne-Laure Taksin^15*, Caroline Lejeune^16*, Sophie Park, MD, PhD¹⁷, Anne Banos, MD^18*, Aristoteles Giagounidis, MD¹⁹, Emmanuel Gyan, MD, PhD²⁰, Mario Ojeda-Uribe, MD^21*, Stefanie Groepper, MD^22*, Fatiha Chermat^23*, Emmanuelle Clappier, Pharm.D., Ph.D.^24*, Uwe Platzbecker, MD²⁵, Pierre Fenaux, MD²⁶ and Lionel Ades, MD, PhD²⁷

¹Hematology department, Saint-Louis Hospital, Paris, France
²Biostatistics and Medical Information Department, Saint Louis Hospital, Assistance Publique — Hôpitaux de Paris (AP-HP), Paris, France
³Hôpital Haut-Lévêque, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France
⁴Centre Hospitalier Universitaire de Nice, Nice, France
⁵Department for Internal Medicine, Toulouse University Hospital, Toulouse, France
⁶Centre Henri Becquerel, Rouen, FRA
⁷Hématologie Clinique, CH Le Mans, Le Mans, France
⁸Department of Hematology, Lyon Sud Hospital, Pierre Benite, FRA
⁹Service des Maladies du Sang, CHU Angers, Angers, France
¹⁰Centre Hospitalier Universitaire d'Angers, Angers, France
¹¹GWT-TUD Gmbh, Dresden, Sachsen, DEU
¹²Department of Biostatistics and Medical Informatics,, Hôpital Saint Louis, GHU AP-HP Nord Université Paris Cité, Paris, FRA
¹³Department of Hematology, Institut Paoli-Calmettes, Centre de Recherche en Cancérologie de Marseille (CRCM, Marseille, France
¹⁴Hematology Department, Hôtel-Dieu University Hospital, NANTES CEDEX 1, France
¹⁵CHu de Versailles, Versailles, France
¹⁶Hematology department, ICLN, CHU Saint-Etienne, Saint etienne, France
¹⁷Hematology Department, CHU Grenoble, Grenoble Cedex 9, France
¹⁸Centre Hospitalier De Bayonne, Bayonne, FRA
¹⁹Clinic for Hematology, Oncology and Palliative Care Marien Hospital Düsseldorf, Dusseldorf, Germany
²⁰Service D'Hematologie Et Therapie Cellulaire, Tours Cedex, France
²¹Clinical Hematology Department, Mulhouse Hospital, Mulhouse, France, Mulhouse, FRA
²²Marien Hospital, University of Düsseldorf, Düsseldorf, Germany
²³Groupe Francophone des Myelodysplasies, Hôpital St Louis/université de Paris Cité, Paris, FRA
²⁴Saint Louis Hospital, Paris, France
²⁵Department for Hematology, Cell Therapy, Hemostaseology and Infectious Diseases, University of Leipzig Medical Center, Leipzig, Germany
²⁶Hopital Saint Louis, Groupe Francophone des Myelodysplasies, Paris, France, PARIS, FRA
²⁷Hopital Saint Louis, Paris, France

Nicole R. Grieselhuber, MD, PhD¹, Praneeth Baratam^2,3, Anjali S. Advani, MD⁴, Abdulraheem Yacoub, MD⁵, Don A. Stevens, MD⁶, Ahmed Aribi, MD^7*, Ben K. Tomlinson, MD⁸, Jay Yang, MD^9,10, Pankit Vachhani, MD^11*, Joseph G Jurcic, MD¹², Caspian H. Oliai, MD¹³, Jessica Liegel, MD¹⁴, Edward Pearson, MD^15*, Anna Van Rhenen, MD, PhD^16*, Marcello Rotta, MD^17*, Kapil Rathi^18*, Juan Pinelli^18*, Tara Chen, PharmD¹⁸ and Amir T. Fathi, MD¹⁹

¹James Cancer Hospital and Ohio State University, Columbus, OH
²Medical University of South Carolina, Charleston, SC
³Hollings Cancer Center, Charleston, SC
⁴Department of Hematology and Medical Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH
⁵University of Kansas Cancer Center, Leawood, KS
⁶Norton Cancer Institute, Norton Health Care, Louisville, KY
⁷Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA
⁸University Hospitals Cleaveland Medical Center, Cleaveland, OH
⁹Karmanos Cancer Institute, Detroit, MI
¹⁰Department of Oncology, Karmanos Cancer Institute/Wayne State University, Detroit, MI
¹¹University of Alabama at Birmingham, Birmingham, AL
¹²Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY
¹³Department of Medicine/Division of Hematology and Oncology, UCLA Medical Center, Los Angeles, CA
¹⁴Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
¹⁵Texas Oncology Baylor Sammons Cancer Center, Dallas, TX
¹⁶University Medical Center Utrecht, Utrecht, Netherlands
¹⁷Colorado Blood Cancer Institute, Denver, CO
¹⁸Pfizer Inc, New York, NY
¹⁹Hematology Oncology, Massachusetts General Hospital Cancer Center, Boston, MA

Yazan F Madanat, MD¹, Amir T. Fathi, MD², Guillermo Garcia-Manero, MD³, Gail J. Roboz, MD⁴, Justin M. Watts, MD⁵, Gabrielle T. Prince, MD^6*, Praneeth Baratam, MBBS⁷, Stephane De Botton^8*, Anthony S. Stein, MD⁹, James M. Foran, MD¹⁰, Martha L. Arellano, MD¹¹, David Sallman, MD¹², Yuanye (Vickie) Zhang^13*, Stephanie M. Kapsalis^13*, Prapti A. Patel, MD¹³ and Courtney D. DiNardo, MD, MSc³

¹UT Southwestern Medical Center, Dallas, TX
²Hematology Oncology, Massachusetts General Hospital Cancer Center, Boston, MA
³University of Texas MD Anderson Cancer Center, Houston, TX
⁴Weill Cornell Medicine and The New York Presbyterian Hospital in New York City, New York, NY
⁵Sylvester Cancer Center, University of Miami, Miami, FL
⁶Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD
⁷Medical University of South Carolina/Hollings Cancer Center, Charleston, SC
⁸Institut Gustave Roussy, Villejuif, France
⁹Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA
¹⁰Division of Hematology & Medical Oncology, Mayo Clinic, Jacksonville, FL
¹¹Winship Cancer Institute of Emory University School of Medicine, Atlanta, GA
¹²Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
¹³Servier Pharmaceuticals, LLC, Boston, MA

Mehmet Sevki Uyanik, MD^1*, Guillermo Garcia-Manero, MD², Abhishek Maiti, MBBS³, Farhad Ravandi, MBBS⁴, Kelly S. Chien, MD⁵, Danielle Hammond, MD², Alexandre Bazinet, MD^2*, Heather Schneider, BSN, RN^1*, Stephany Hendrickson^6*, Sherry Pierce, BSN, BA^2*, Hagop M. Kantarjian, MD², Naveen Pemmaraju, MD² and Guillermo Montalban-Bravo, MD²

¹Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, The University of Texas Health Science Center At Houston, Houston, TX
⁴Department of Leukemia, University of Texas- MD Anderson Cancer Center, Houston, TX
⁵Department of Leukemia, MD Anderson, Houston, TX
⁶Leukemia Department, The University of Texas MD Anderson Cancer Center, Houston, TX

Jeremy V. DiGennaro, DO¹, Dimitrios Drekolias, MD^2*, Najla H. Al Ali, Ms^3*, Onyee Chan, MD⁴, Seongseok Yun, MD, PhD^5*, Alison R. Walker, MD, MBA, MPH⁶, Zhuoer Xie, MD, MS⁵, Eric Padron, MD⁷, Jeffrey E Lancet, MD⁷, Rami S. Komrokji, MD⁸ and David Sallman, MD⁸

¹Department of Internal Medicine, The University of South Florida Morsani College of Medicine, Tampa, FL
²Department of Hematology/Oncology, University of South Florida, Morsani College of Medicine, Tampa, FL
³Department of Malignant Hematology, H. Lee Moffitt Cancer Center, Tampa
⁴Department of Malignant Hematology, University of Arizona, Banner University Medical Center-Tucson, Tampa, FL
⁵Department of Malignant Hematology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL
⁶Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Wesley Chapel, FL
⁷Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
⁸Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL

Pierantonio Russo, MD^1*, Ramaa Nathan^2*, Daniel Pfeffer^2* and Alex Moore^2*

¹Corporate Medical, Eversana, Cherry Hill, NJ
²Data Science, Eversana, Kansas City, KS

Rami S. Komrokji, MD¹, Zaker I. Schwabkey, MD¹, Najla H. Al Ali, Ms^2*, Luis E. Aguirre, MD³, Maximilian Stahl, MD⁴, Somedeb Ball, MD⁵, Emily F. Mason, MD, PhD^6*, Michael R. Savona, MD⁷, Valeria Santini, MD⁸, Angela Consagra, MD^9*, Uwe Platzbecker, MD¹⁰, Anne Sophie Kubasch, MD¹¹, Yazan F Madanat, MD¹², Pierre Fenaux, MD¹³, Lin-Pierre Zhao, MD^14*, Mikkael A. Sekeres, MD¹⁵, Namrata S. Chandhok, MD¹⁶, Matteo Giovanni Della Porta, MD^17*, Luca Lanino, MD¹⁸, Amy E. DeZern, MD, MHS¹⁹, David Sallman, MD², Zhuoer Xie, MD, MS¹, Eric Padron, MD¹, Koji Sasaki, MD²⁰, Kensuke Takaoka, MD, MSc²¹, Akhil Jain, MD^20*, Mónica Del Rey^22*, Maria Diez-Campelo, MD, PhD^23* and Guillermo Garcia-Manero, MD²⁰

¹Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL
²Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
³Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
⁴Dana Farber Cancer Institute, Boston, MA
⁵Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN
⁶Department of Pathology, Microbiology, Immunology, Vanderbilt University Medical Center, Nashville, TN
⁷Vanderbilt University Medical Center, Nashville, TN
⁸MDS Unit, Hematology, AOUC, University of Florence, Florence, Italy
⁹MDS Unit, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
¹⁰Department for Hematology, Cell Therapy, Hemostaseology and Infectious Diseases, University of Leipzig Medical Center, Leipzig, Germany
¹¹Department of Hematology, Cellular Therapy, Hemostaseology and Infectious Diseases, University Leipzig Medical Center, Leipzig, Germany
¹²Division of Hematology/Oncology, Department of Internal Medicine, University of Texas Southwestern, Dallas, TX
¹³Department of Hematology, Université de Paris, Saint-Louis Hospital, Paris, France
¹⁴Hématologie Seniors, Université Paris Cité, APHP, Hôpital Saint-Louis, Paris, France
¹⁵Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL
¹⁶Sylvester Comprehensive Cancer Center, University of Miami-Miller School of Medicine, Miami, FL
¹⁷IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
¹⁸IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy
¹⁹The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD
²⁰Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²¹University of Hawaii Internal Medicine Residency Program, Honolulu, HI
²²Department of Hematology, Salamanca-IBSAL University Hospital, Salamanca, Spain
²³University of Salamanca, IBSAL, IBMCC, CSIC, Cancer Research Center, Department of Hematology - Hospital Universitario de Salamanca, Salamanca, Spain