Chaja Feige Jacobs, MD^1,2,3,4,5*, Yannick D'Hargues^6,7,8*, Sandra Robrecht, PhD^6,9*, Moritz Fürstenau, MD^9,10*, Kirsten Fischer, MD^6,9*, Anna Maria Fink, MD^6,9*, Stephan Stilgenbauer, MD¹¹, Christof Schneider, MD^11*, Eugen Tausch, MD^11*, Carsten Utoft Niemann, MD, PhD^12*, Caspar da Cunha-Bang, MD, PhD^12*, Julie Dubois, MD, PhD^2,3*, Ellen Van Der Spek, MD, PhD^13*, Andre Vlot, MD, PhD^14*, Yorick Sandberg^15*, Mark-David Levin¹⁶, Michael Hallek, MD^6,9*, Barbara F. Eichhorst, MD^6,9, Arnon P. Kater, MD, PhD^2,3,4 and Fleur S. Peters, PhD^3,17,18,19*

¹Experimental Immunology, University of Amsterdam, Amsterdam, Netherlands
²Department of Hematology, University of Amsterdam, Amsterdam, Netherlands
³Cancer Immunology, Amsterdam institute for Immunology and Infectious diseases, Amsterdam, Netherlands
⁴Cancer Immunology, LYMMCARE, Cancer Center Amsterdam, Amsterdam, Netherlands
⁵* Co-first author, Amsterdam, Netherlands
⁶Department I of Internal Medicine, Faculty of Medicine and Cologne University Hospital, Cologne, Germany
⁷Mildred Scheel School of Oncology, Cologne, Germany
⁸*Co-first author, Cologne, Germany
⁹German CLL Study Group, University of Cologne, Cologne, Germany
¹⁰Department I of Internal Medicine, Faculty of Medicine and Cologne University Hospital, Koeln, Germany
¹¹Department of Internal Medicine III, Division of CLL, University Hospital Ulm, Ulm, Germany
¹²Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
¹³Department of Internal Medicine, Rijnstate Hospital, Arnhem, Netherlands
¹⁴Department of Internal Medicine, Rijnstate Hospital, Zevenaar, Netherlands
¹⁵Deparment of Internal Medicine, Maasstad Hospital, Rotterdam, Netherlands
¹⁶Department of Internal Medicine, Albert Schweitzer Hospital, Dordrecht, Netherlands
¹⁷Department of Hematology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
¹⁸Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
¹⁹Cancer Immunology, Cancer Center Amsterdam, Amsterdam, Netherlands

Stuart Lanham, PhD^1*, Luis Del Rio Fernandez^1*, Stefano de Pretis, PhD^2*, Joshua Grant^1*, Isla Henderson^1*, Benjamin Sale, MSc^1*, Lauren Griffith, PhD^1*, David Dutton, MD DM^3*, Giovanni Tonon^4*, Freda K. Stevenson, DPhil¹ and Francesco Forconi^1*

¹School of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
²IRCCS San Raffaele Institute, Milan, Italy
³Haematology Dept, Cancer Care, University of Southampton NHS Hospital Trust, Southampton, United Kingdom
⁴Vita-Salute San Raffaele University, Milan, Italy

Wael Gamal, PhD^1,2, Melanie Mediavilla Varela, PhD^2*, Angimar Uriepero Palma, MD, MMSc^3*, Mohammad Ammad Ud Din, MBBS⁴, Julio C. Chavez, MD⁵, Eva Sahakian, PhD^2,4*, Paulo C. Rodriguez, PhD^2* and Javier Pinilla-Ibarz, MD, PhD⁴

¹Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL
²Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
³Department of Internal Medicine, Jefferson Einstein Hospital, Philadelphia, PA
⁴Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
⁵Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Lutz, FL

Martina Cardillo, PhD^1*, Matthew J Friedman^2*, Anita Ng, PhD¹, Randall S. Davis, MD³, Xiao J. Yan¹, Ashna Shah^2*, Michael Ryan^4*, Peter K Gregersen, MD^4*, Steven L. Allen⁵, Jonathan E Kolitz, MD⁵, Kanti R. Rai⁶, Paolo Ghia, MD, PhD⁷ and Nicholas Chiorazzi¹

¹Karches Center for Oncology Research, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY
²Hofstra University, Hempstead, NY
³University of Alabama at Birmingham, Birmingham, AL
⁴Robert S. Boas Center for Genomics & Human Genetics, The Feinstein Institutes for Medical Research, Manhasset, NY
⁵Department of Medicine, Northwell Health, Manhasset, NY
⁶Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY
⁷Università Vita-Salute San Raffaele, Milan, Italy

Natalia Timofeeva, MD¹, Breana Herrera, BS^1*, Shady I. Tantawy, MD¹, Hitomi Fujiwara, PhD^2*, Lizbeth Loza^1*, Mariko Hatakeyama^2*, Tokiko Asami^2*, Hiroshi Ohmoto^2*, Kyoko Miyamoto^3*, Yu Nishioka^2*, Akinori Arimura^3*, Masaaki Sawa, PhD^2*, Nitin Jain, MD⁴ and Varsha Gandhi, PhD^1,4

¹Department of Experimental Therapeutics, MD Anderson Cancer Center, Houston, TX
²Carna Biosciences, Inc., Kobe, Japan
³CarnaBio USA, Inc., South San Francisco, CA
⁴Department of Leukemia, MD Anderson Cancer Center, Houston, TX

Gonzalo Blanco^1*, Xiao J. Yan¹, Anita Kar Yun Ng¹, Andrew Shih^2*, Jonathan E. Kolitz^3*, Steven L. Allen³, Kanti R. Rai³ and Nicholas Chiorazzi¹

¹Karches Center for Oncology Research, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY
²Robert S. Boas Center for Genomics and Human Genetics, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY
³Department of Medicine, Northwell Health, Manhasset, NY

Emanuela M. Ghia, PhD^1,2,3*, Michael Y. Choi, MD⁴, George F. Widhopf II, PhD^1,2,3* and Thomas J. Kipps, MD^1,2,3

¹Center for Novel Therapeutics, University of California, San Diego, La Jolla, CA
²Division of Hematology Oncology, Department of Medicine, University of California, San Diego, La Jolla, CA
³Moores Cancer Center, University of California, San Diego, La Jolla, CA
⁴Moores Cancer Center, University of California San Diego, La Jolla, CA

Yu-Ju Chen^1*, Nikhil Trepeta^2*, Stella Fratti^1*, Kelly Wong^1*, Alan G. Ramsay, BSc, MSc, PhD³ and Shih-Shih Chen, PhD¹

¹Institute of Molecular Medicine, The Feinstein Institutes for Medical Research, Northwell Health System, Manhasset, NY, Manhasset, NY
²Institute of molecular medicine, The Feinstein Institutes for Medical Research, Northwell Health System, Manhasset, NY, Manhasset, NY
³King's College London, London, GBR

Valentina Griggio^1*, Candida Vitale, MD, PhD^2*, Rebecca Jones^3*, Giorgia Mancin^3*, Giulia Bondielli^3*, Andrea Visentin, MD, PhD^4*, Riccardo Moia, MD^5*, Anna Maria Frustaci, MD^6*, Veronica Mattiello, MD^7*, Marzia Varettoni^8*, Francesca Perutelli, MD^3*, Maria Chiara Montalbano^9*, Giacomo Ortone^3*, Gioacchino Catania, MD^10*, Paolo Sportoletti^11*, Luca Laurenti, MD^12*, Francesca Romana Mauro, MD^13*, Lorella Orsucci^14*, Luca Arcaini^15*, Francesco Passamonti, MD^16*, Marina Deodato, MD^17*, Gianluca Gaidano, MD, PhD¹⁸, Livio Trentin¹⁹, Benedetto Bruno, MD, PhD²⁰ and Marta Coscia, MD, PhD^21,22*

¹Torino, Italy
²Division of Hematology, A.O.U. Città della Salute e della Scienza di Torino and Department of Molecular Biotechnology and Health Sciences, University of Torino, Turin, Italy
³A.O.U. Città della Salute e della Scienza di Torino e Dipartimento di Biotecnologie Molecolari e Scienze per la Salute, Università di Torino, Torino, Italy
⁴Hematology unit, Department of Medicine, University of Padova, Padova, Italy
⁵Novara, Italy
⁶ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy
⁷Hematology Department, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico of Milan, Milan, Italy
⁸Division of Hematology, Fondazione IRCCS Policlinico S. Matteo University of Pavia, Pavia, Italy
⁹12. Department of Molecular Biotechnology and Health Sciences, University of Torino and Division of Hematology, University Hospital (A.O.U.) Città della Salute e della Scienza di Torino, Torino, Italy
¹⁰Hematology and Marrow Transplant,, A.O. SS Antonio e Biagio e Cesare Arrigo, Alessandria, Alessandria, ITA
¹¹Department of Medicine and Surgery, Institute of Hematology, Centro di Ricerca Emato Oncologica (CREO), University of Perugia, Perugia, Italy
¹²Hematology Section, Department of Radiological and Hematological Sciences, Catholic University of Sacred Heart, Rome, Italy
¹³Hematology, Department of Translational and Precision Medicine, Sapienza University, Roma, Italy
¹⁴Hematology Division, A.O.U Città della Salute e della Scienza, Ospedale S. Giovanni Battista Molinette, Torino, Italy
¹⁵Division of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
¹⁶Dipartimento di Oncologia ed Ematologia, Università degli Studi di Milano, Policlinico di Milano, Ospedale Maggiore, Fondazione I.R.C.C.S. Ca Granda, Milano, Italy
¹⁷Dipartimento di Ematologia, ASST Grande Ospedale Metropolitano Niguarda, Niguarda Cancer Center, Milan, Italy, Milano, Italy
¹⁸Division of Hematology, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy
¹⁹Hematology Unit, Azienda Ospedale-Università Padova (AOPD), Padua, Italy
²⁰Hematology Division I, Department of Molecular Biotechnologies and Health Sciences, University of Turin/University Hospital A.O.U. “Città della Salute e della Scienza”, Turin, Italy
²¹Hematology Division, ASST Sette Laghi, Ospedale di Circolo, Varese, Italy
²²Department of Medicine and Surgery, University of Insubria, Varese, Italy