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1845 Myelodysplastic Syndromes with Concomitant SF3B1 Mutation and Deletion of the Long Arm of Chromosome 5 (SF3B1del5q): Outcomes and Response to Treatment

Program: Oral and Poster Abstracts
Session: 637. Myelodysplastic Syndromes: Clinical and Epidemiological: Poster I
Hematology Disease Topics & Pathways:
MDS, Chronic Myeloid Malignancies, Diseases, Myeloid Malignancies
Saturday, December 7, 2024, 5:30 PM-7:30 PM

Rami S. Komrokji, MD1, Zaker I. Schwabkey, MD1, Najla H. Al Ali, Ms2*, Luis E. Aguirre, MD3, Maximilian Stahl, MD4, Somedeb Ball, MD5, Emily F. Mason, MD, PhD6*, Michael R. Savona, MD7, Valeria Santini, MD8, Angela Consagra, MD9*, Uwe Platzbecker, MD10, Anne Sophie Kubasch, MD11, Yazan F Madanat, MD12, Pierre Fenaux, MD13, Lin-Pierre Zhao, MD14*, Mikkael A. Sekeres, MD15, Namrata S. Chandhok, MD16, Matteo Giovanni Della Porta, MD17*, Luca Lanino, MD18, Amy E. DeZern, MD19, David Sallman, MD2, Zhuoer Xie, MD, MS20, Eric Padron, MD1, Koji Sasaki, MD21, Kensuke Takaoka, MD, MSc22, Akhil Jain, MD21*, Mónica Del Rey23*, Maria Diez-Campelo, MD, PhD24* and Guillermo Garcia-Manero, MD21

1Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL
2Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
3Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
4Dana Farber Cancer Institute, Boston, MA
5Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN
6Department of Pathology, Microbiology, Immunology, Vanderbilt University Medical Center, Nashville, TN
7Vanderbilt University Medical Center, Nashville, TN
8MDS Unit, Hematology, AOUC, University of Florence, Florence, Italy
9MDS Unit, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
10Department for Hematology, Cell Therapy, Hemostaseology and Infectious Diseases, University of Leipzig Medical Center, Leipzig, Germany
11Department of Hematology, Cellular Therapy, Hemostaseology and Infectious Diseases, University Leipzig Medical Center, Leipzig, Germany
12Division of Hematology/Oncology, Department of Internal Medicine, University of Texas Southwestern, Dallas, TX
13Department of Hematology, Université de Paris, Saint-Louis Hospital, Paris, France
14Hématologie Seniors, Université Paris Cité, APHP, Hôpital Saint-Louis, Paris, France
15Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL
16Sylvester Comprehensive Cancer Center, University of Miami-Miller School of Medicine, Miami, FL
17IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
18IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy
19The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD
20Department of Malignant Hematology, Moffitt Cancer Center, Lutz, FL
21Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
22University of Hawaii Internal Medicine Residency Program, Honolulu, HI
23Department of Hematology, Salamanca-IBSAL University Hospital, Salamanca, Spain
24University of Salamanca, IBSAL, IBMCC, CSIC, Cancer Research Center, Department of Hematology - Hospital Universitario de Salamanca, Salamanca, Spain

Background

Both MDS-SF3B1 and isolated del(5q) MDS are recognized by WHO and ICC 2022 as unique molecularly-defined MDS entities. Reports including the molecular revised international prognostic scoring system (IPSS-M) indicate that concomitant SF3B1 mutation (MT) with del(5q) is associated with less favorable outcome. SF3B1del5q accounted for 7% of all SF3B1 cases in the IPSS-M cohort. Lenalidomide (Len) is the treatment of choice for isolated del(5q) MDS and luspatercept (Luspa) for MDS-SF3B1. However, there are scarce data about response of SF3B1del5q to either Len or Luspa. Hence, we assessed the hematological response rate to therapies including Len and Luspa among lower-risk (LR) MDS patients (pts) with SF3B1del5q . We also compared outcomes for MDS- SF3B1del5q pts to MDS-SF3B1 and del5qMDS.

Methods

This was a multicenter international retrospective analysis for pts diagnosed with concomitant del5q and SF3B1, less than 5% myeloblasts, no complex karyotype who received at least one line of therapy. Hematological improvement (HI) was defined as hemoglobin (Hgb) increase 1.5 g/dl or more in non-transfusion dependent pts, or red blood cell transfusion independence among transfusion dependent pts. We identified 2 comparison cohorts, MDS-SF3B1 cohort and isolated del5q-MDS cohort to compare baseline characteristics and outcomes.

Results

Among 77 LR-MDS pts with SF3B1del5q, the median age at diagnosis was 70 years (30-87), 74% were female, 97% white and 13% classified as t-MDS. The median Hgb was 9.3 g/dl (5-13), median platelets 250 × 109/L (32-1330) and median ANC 2.01 × 109/L (1-11). The most common other concomitant somatic MT were TP53 (26%), DNMT3A (23%) and TET-2 (21%). The median TP53 VAF was 16% (1-66%). R248W TP53 was most common hot spot (20%).

First-line therapy was Len for 46 pts (61%), erythroid stimulating agents (ESA) for 18 pts (23%), Luspa for 4 pts (5%), hypomethylating agents (HMA) for 6 pts (8%) and other therapies for 2 pts (3%). Among 72 evaluable pts for response, the HI rate to 1st line therapy was 53% (37 pts). The HI rate to Len, ESA, HMA and Luspa was 64%, 42%, 20% and no response respectively as 1st line.

Forty-seven pts received 2nd line therapy, 12 (26%) Len, 4 (9%) Luspa, 22 (47%) HMA, 1 ESA, and 8 (17%) other treatments. Among 39 evaluable pts, the HI rate to 2nd line therapy was 43% (17 Pts). The HI rate was 46% (5/11 pts), 50% (2/4 pts), 47% (8/17 pts) for Len, Luspa and HMA as 2nd line therapy respectively.

Among 38 pts who received ESA at any time, 33 were evaluable for response, and the HI rate was 27% (9pts). Among 60 pts who received Len at any time, 57 were evaluable for response, and the HI rate was 59%. There was no difference in response among TP53 WT (61%) vs 50% for TP53 MT (p=.4). Among 16 pts who received Luspa at any time, the HI rate was 18%. Finally, 37 pts received HMA at any time, 32 evaluable for response, with an HI=37%.

The median overall survival (mOS) for the whole cohort was 66 months (mo) (95%CI 53-79). The mOS was 109 mo for TP53 WT compared to 64 mo for TP53 MT (p=0.22).

We compared the 77 MDS SF3B1del5q cohort to 382 MDS-SF3B1 pts and 133 MDS isolated del5q MDS pts. Outcome for SF3B1del5q MDS pts was closer to del5q MDS and inferior to MDS-SF3B1. HR for OS was 0.67 (95%CI .46-.98) (p=0.038) for MDS-SF3B1 and 0.79 (95% CI 0.51-1.2) (p=.28) for del5q pts compared to SF3B1del5q. Median OS was 66, 82, and 103 mo respectively for SF3B1del5q, del5q, and MDS-SF3B1 (p=0.1). The rate of AML transformation was 20%,12% and 5% respectively, p<.005. Baseline counts and demographics were similar except for more MDS-SF3B1 observed in males. The concomitant MT were different, where more TP53 observed in 26%, 18%, and 2% respectively (p<0.005). No JAK-2 mutations observed in SF3B1del5q group. Higher ESA response was observed among MDS-SF3B1 group, and similar response to Len among del5q and SF3B1del5q.

Conclusions

In this largest retrospective cohort of concomitant SF3B1del5q MDS pts to date, we report mOS of 66 mo, which is better than what was reported in IPSS-M for this group. Contrary to IPSS-M, our analysis was limited to pts with less than 5% myeloblasts. The mOS of SF3B1del5q was still inferior to either isolated del5q or SF3B1 entities and maybe driven by higher rate of concurrent TP53 MT observed. Response to Len was similar to isolated del5q whereas response to Luspa was inferior to MDS-SF3B1 and more observed as 2nd line therapy. Our data suggest that Len should be 1st line therapy for those pts followed by Luspa and HMA.

Disclosures: Komrokji: Sobi: Consultancy, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; DSI: Honoraria, Membership on an entity's Board of Directors or advisory committees; Taiho: Membership on an entity's Board of Directors or advisory committees; BMS: Honoraria, Membership on an entity's Board of Directors or advisory committees; Jazz Pharmaceuticals: Consultancy, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; AbbVie: Consultancy, Membership on an entity's Board of Directors or advisory committees; Celgene/BMS: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding; Geron: Consultancy, Membership on an entity's Board of Directors or advisory committees; Janssen: Consultancy; Servier: Consultancy, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; PharmaEssentia: Consultancy, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Sumitomo Pharma: Consultancy, Membership on an entity's Board of Directors or advisory committees; Servio: Membership on an entity's Board of Directors or advisory committees; Keros: Membership on an entity's Board of Directors or advisory committees; Rigel: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Genentech: Consultancy; DSI: Consultancy, Membership on an entity's Board of Directors or advisory committees; Servio: Honoraria; CTI biopharma: Membership on an entity's Board of Directors or advisory committees; BMS: Research Funding; Novartis: Membership on an entity's Board of Directors or advisory committees. Stahl: Sobi: Membership on an entity's Board of Directors or advisory committees; BMS: Membership on an entity's Board of Directors or advisory committees; Rigel: Membership on an entity's Board of Directors or advisory committees; Kymera: Membership on an entity's Board of Directors or advisory committees; Sierra Oncolgy: Membership on an entity's Board of Directors or advisory committees; GSK: Membership on an entity's Board of Directors or advisory committees; Syndax: Membership on an entity's Board of Directors or advisory committees. Savona: AbbVie; Bristol Myers Squibb; CTI BioPharma Corp.; Geron; Karyopharm; Novartis Pharmaceuticals Corporation; Ryvu Therapeutics; and Sierra Oncology, Inc.: Consultancy; ALX Oncology Inc.; Astex Pharmaceuticals; Incyte Corporation; and Takeda Pharmaceutical Company Limited.: Research Funding; Empath Biosciences; Karyopharm and Ryvu Therapeutics: Current holder of stock options in a privately-held company; Astex Pharmaceuticals for travel grant.: Other: Financial or Material Support. Santini: Ascentage, AbbVie, Bristol Myers Squibb, CTI BioPharma, Geron, Gilead, Novartis, Servier, Syros Pharmaceuticals: Other: Advisory Board. Platzbecker: Amgen: Consultancy, Research Funding; BMS: Consultancy, Membership on an entity's Board of Directors or advisory committees, Other: Travel support, Research Funding; MDS Foundation: Membership on an entity's Board of Directors or advisory committees; Abbvie: Consultancy, Research Funding; Curis: Consultancy, Honoraria, Research Funding; Geron: Consultancy; Janssen: Consultancy, Honoraria, Research Funding; Merck: Research Funding; Novartis: Consultancy, Research Funding. Kubasch: Curis: Research Funding; BMS: Honoraria; Novartis: Honoraria, Research Funding; Janssen: Honoraria, Research Funding. Madanat: OncLive, MD Education, Sierra Oncology, Stemline, MorphoSys: Consultancy; Sierra Oncology, Stemline Therapeutics, Blueprint Medicines, Morphosys, Taiho Oncology, SOBI, Rigel Pharmaceuticals, Geron, Cogent Biosciences and Novartis: Other: Advisory Board; Taiho Oncology, Rigel Pharmaceuticals, Novartis: Consultancy; Blueprint Medicines, MD Education, and Morphosys: Other: travel; BMS, Kura Oncology, BluePrint Medicines, Geron: Consultancy. Fenaux: Jazz Pharmaceuticals: Honoraria, Research Funding; Astex: Research Funding; Janssen: Research Funding; Agios: Research Funding; Novartis: Research Funding; Servier: Research Funding; AbbVie: Honoraria, Research Funding; BMS: Honoraria, Research Funding. Sekeres: Bristol Myers Squibb: Membership on an entity's Board of Directors or advisory committees, Research Funding; Kurome: Membership on an entity's Board of Directors or advisory committees; Schroedinger: Membership on an entity's Board of Directors or advisory committees. Della Porta: Bristol Myers Squibb: Consultancy. DeZern: servier: Membership on an entity's Board of Directors or advisory committees; Shattuck Labs: Membership on an entity's Board of Directors or advisory committees; Keros: Membership on an entity's Board of Directors or advisory committees; geron: Other: dsmb; Astellas: Honoraria; Appellis: Membership on an entity's Board of Directors or advisory committees; Bristol Myers Squibbs: Membership on an entity's Board of Directors or advisory committees. Sallman: Abbvie: Consultancy; Agios: Consultancy; Axiom: Consultancy; Gilead: Consultancy; Celyad: Consultancy; Froghorn: Consultancy; Incyte: Consultancy; Intellisphere, LLC: Consultancy; Johnson & Johnson: Consultancy; Kite: Consultancy, Membership on an entity's Board of Directors or advisory committees; Magenta Therapeutics: Consultancy, Membership on an entity's Board of Directors or advisory committees; NextTech: Consultancy; Novartis: Consultancy, Membership on an entity's Board of Directors or advisory committees; AvenCell: Membership on an entity's Board of Directors or advisory committees; Astellas: Membership on an entity's Board of Directors or advisory committees; BlueBird Bio: Membership on an entity's Board of Directors or advisory committees; BMS: Membership on an entity's Board of Directors or advisory committees; Dark Blue Therapeutics: Membership on an entity's Board of Directors or advisory committees; Intellia: Membership on an entity's Board of Directors or advisory committees; Jasper Therapeutics: Membership on an entity's Board of Directors or advisory committees; NKARTA: Membership on an entity's Board of Directors or advisory committees; Orbital Therapeutics: Membership on an entity's Board of Directors or advisory committees; Rigel Pharmaceuticals: Membership on an entity's Board of Directors or advisory committees; Shattuck Labs: Membership on an entity's Board of Directors or advisory committees; Servier: Membership on an entity's Board of Directors or advisory committees; Syndax: Membership on an entity's Board of Directors or advisory committees; Syros: Membership on an entity's Board of Directors or advisory committees; Apera: Research Funding; Jazz: Research Funding. Sasaki: Enliven: Research Funding; Pfizer: Consultancy; Novartis: Consultancy, Research Funding; Daiichi-Sankyo: Consultancy; Otsuka: Other: Lecture fees; Chugai: Other: Lecture fees. Diez-Campelo: SYROS: Membership on an entity's Board of Directors or advisory committees; Gilead: Other: Travel reimbursement; ASTEX/OTSUKA: Membership on an entity's Board of Directors or advisory committees, Other: TRAVEL TO MEETINGS; HEMAVAN: Membership on an entity's Board of Directors or advisory committees; BMS/Celgene: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Other: Advisory board fees; AGIOS: Consultancy, Membership on an entity's Board of Directors or advisory committees; BLUEPRINT MEDICINES: Consultancy, Membership on an entity's Board of Directors or advisory committees; GSK: Consultancy, Membership on an entity's Board of Directors or advisory committees; Novartis: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; KEROS: Honoraria, Membership on an entity's Board of Directors or advisory committees; CURIS: Membership on an entity's Board of Directors or advisory committees. Garcia-Manero: Onconova: Research Funding; Merck: Research Funding; H3 Biomedicine: Research Funding; Genentech: Research Funding; Genentech: Other: Personal fees; Astex: Other: Personal fees; Forty Seven: Research Funding; Helsinn: Other: Personal fees; Amphivena: Research Funding; Astex: Research Funding; Janssen: Research Funding; AbbVie: Research Funding; Novartis: Research Funding; Helsinn: Research Funding; Bristol Myers Squibb: Other: Personal fees, Research Funding; Curis: Research Funding; Aprea: Research Funding.

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