Suning Chen, MD, PhD^1*, Depei Wu, MD, PhD², Wenzhi CAI, PhD^1*, Xueqing Dou^1*, Zhenfang Liu, MD^3*, Yu Zhu, MD^4*, Ying Wang, MD^1*, Chunmei Yang^5*, Jiong Hu, MD⁶, Miao Miao^1*, Xiuzhi Deng^7* and Chunyan Chen^8*

¹National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China
²Department of Hematology, the First Affiliated Hospital of Soochow University, Collaborative Innovation Center of Hematology, Institute of Blood and Marrow Transplantation, Suzhou, China
³The First Affiliated Hospital of Guangxi Medical University, Nanning, China
⁴Department of Hematology, Jiangsu Provincial People's Hospital, Nanjing, China
⁵The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
⁶Shanghai Institute of Hematology, RuiJin Hospital Medical School, Shanghai JiaoT, Shanghai, China
⁷Weihai Municipal Hospital, Weihai, China
⁸Department of Hematology, Qilu Hospital of Shandong University, Jinan, China

Shiwei Hu^1*, Xiudi Yang, MD^1*, Xiaoqiong Zhu^2*, Honglan Qian^3*, Ying Lu^4*, Yanxia Han^5*, Huafeng Wang^6* and Jian Huang, MD, PhD⁷

¹Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
²Department of Hematology, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, China
³Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
⁴Department of Hematology, The Affiliated People's Hospital of Ningbo University, Ningbo, China
⁵Department of Hematology, The Second Hospital of Jiaxing, Jiaxing, China
⁶The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
⁷Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

Janick Caron-L'Ecuyer¹, Michaël Harnois, MSc^2*, Marie-Christine Meunier^3*, Vincent Ethier, MD, BSc⁴, Genevieve Huynh-Trudeau, MD⁵, Lissa Ajjamada, MD^6*, Lambert Busque, MD^1,2,7 and Natasha Szuber, MD, MSc^1,2,7

¹Université de Montréal, Montreal, QC, Canada
²Quebec CML-MPN Research Group, Montreal, QC, Canada
³Molecular diagnosis laboratory, Maisonneuve-Rosemont Hospital, Montreal, Canada
⁴Centre Hospitalier Universitaire de Sherbrooke (CHUS), Sherbrooke, Canada
⁵Charles-Le Moyne Hospital, Greenfield Park, QC, Canada
⁶Santa Cabrini Hospital, Montreal, Canada
⁷Department of Hematology, Maisonneuve-Rosemont Hospital, Montreal, QC, Canada

Katie Erdos^1*, Aya Alshareef^2*, Richard T. Silver, MD¹, Joseph M. Scandura, MD, PhD¹ and Ghaith Abu-Zeinah, MD³

¹Richard T. Silver, MD Myeloproliferative Neoplasms Center, Weill Cornell Medicine, New York, NY
²Weill Cornell Medicine Qatar, Doha, Qatar
³Weill Cornell Medicine, New York, NY

Ayalew Tefferi, MD¹, Giuseppe Gaetano Gaetano Loscocco^2*, Moazah Iftikhar, MBBS^3*, Masooma S Rana, MBBS^3*, Yamna Jadoon, MBBS⁴, Alessandro Atanasio, MD^2*, Fiorenza Vanderwert^5*, Alessio Enderti^6*, Animesh D. Pardanani, MBBS, PhD³, Natasha Szuber, MD, MSc⁷, Alessandra Carobbio^8*, Tiziano Barbui, MD^9*, Paola Guglielmelli, MD, PhD¹⁰, Naseema Gangat, MBBS¹ and Alessandro Maria Vannucchi¹¹

¹Division of Hematology, Mayo Clinic, Rochester, MN
²CRIMM, Center for Research and Innovation of Myeloproliferative Neoplasms, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy
³Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN
⁴UMass Chan Medical School Baystate, Broad Brook, CT
⁵SOD Ematologia, Università di Firenze, AOU Careggi, Firenze, Italy; Centro Ricerca e Innovazione Malattie Mieloproliferative (CRIMM), Firenze, Italy
⁶Department of Experimental and Clinical Medicine, Centro di Ricerca e Innovazione Malattie Mieloproliferative (CRIMM), AOU Careggi, University of Florence, Florence, Italy
⁷Institut universitaire d'hématologie-oncologie et de thérapie cellulaire, Université de Montréal, Montreal, QC, Canada
⁸Fondazione per la Ricerca Ospedale di Bergamo (FROM), Bergamo, Italy
⁹FROM Research Foundation ASST Papa Giovanni XXIII Bergamo, Bergamo, ITA
¹⁰CRIMM, Center of Research and Innovation of Myeloproliferative Neoplasms, University of Florence, AOU Careggi, Florence, Italy
¹¹Department of Experimental and Clinical Medicine, Centro di Ricerca e Innovazione Malattie Mieloproliferative (CRIMM), AOU Careggi, University of Florence, Firenze, Tuscany, Italy

Shiwei Hu^1*, Xiudi Yang, MD^1*, Ying Lu^2*, Gang Zhang^3*, Xianghua Lang^4*, Li Huang^5* and Jian Huang, MD, PhD⁶

¹Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
²Department of Hematology, The Affiliated People's Hospital of Ningbo University, Ningbo, China
³Department of Hematology, The First Hospital of Jiaxing, The Affiliated Hospital of Jiaxing University, Jiaxing, China
⁴Department of Hematology, Yongkang First People’s Hospital Affiliated to Hangzhou Medical College, Jinhua, China
⁵Department of Hematology, Jinhua People's Hospital, Jinhua, Zhejiang Province, China
⁶Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

Leah A Goldberg, MD^1*, James J. Yoon, MD², Hannah Johnston, MD³, Marta Beata Davidson, MD, PhD⁴, Alexa Siddon, M.D.^5*, Rory M. Shallis, MD⁶, Evan C. Chen, MD⁷, Madelyn Burkart, M.D.⁸, Timothy S. Oh, MD^8*, Sunil G. Iyer, MD⁹, Ellen Madarang, PharmD^10*, Chandrasekar Muthiah, MD¹¹, Joshua Kassner, MD^12*, Raajit Rampal, MD, PhD¹³, Guru Subramanian Guru Murthy, MBBS¹⁴, Terrence Bradley, MD¹⁵, Yasmin Abaza, MD¹⁶, Jacqueline S. Garcia, MD¹⁷, Vikas Gupta, MD, FRCP, FRCPath¹⁸, Kristen M. Pettit, MD¹⁹, Olatoyosi Odenike, MD²⁰, John F. Cursio, PhD^21* and Anand Ashwin Patel, MD²⁰

¹Department of Internal Medicine, University of Chicago Medical Center, Chicago, IL
²University of Michigan, Ann Arbor, MI
³Section of Hematology/Oncology, The University of Chicago, Chicago, IL
⁴Leukemia program, Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON, Canada
⁵Section of Hematology, Department of Medicine, Yale University School of Medicine, New Haven, CT
⁶Department of Internal Medicine, Section of Hematology, Yale School of Medicine - Yale Cancer Center, Killingworth, CT
⁷Adult Leukemia Program, Medical Oncology, Medford, MA
⁸Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL
⁹Division of Hematology and Oncology, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY
¹⁰Leukemia Service, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL
¹¹Division of Hematology-Oncology, Medical College of Wisconsin, Milwaukee, WI
¹²Department of Internal Medicine, New York-Presbyterian/Weill Cornell Medical Center, New York, NY
¹³Memorial Sloan Kettering Cancer Center, New York, NY
¹⁴Division of Hematology/Oncology, Medical College of Wisconsin, Milwaukee, WI
¹⁵University of Miami Sylvester Comprehensive Cancer Center, Miami, FL
¹⁶Northwestern University, Chicago, IL
¹⁷Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
¹⁸The Princess Margaret Cancer Centre, Toronto, ON, Canada
¹⁹Department of Internal Medicine, Division of Hematology/Oncology, C.S. Mott Children's Hospital, Ann Arbor, MI
²⁰Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL
²¹University of Chicago Biological Sciences Division, Chicago, IL

Andrea Duminuco, MD^1*, Sukhraj Singh Virdee^1*, Raj Vaghela^1*, Kyaw Htin Thaw^1*, Claire Woodley^1*, Susan Asirvatham^1*, Priya Sriskandarajah^1*, Hugues de Lavallade, MD, PhD^1*, Deepti H. Radia^1*, Natalia Curto-Garcia^1*, Jennifer O'Sullivan^1*, Andrew Doyle^2*, Shahram Kordasti, MD, PhD¹, Giuseppe Alberto Palumbo, MD^3*, Claire Harrison⁴ and Patrick Harrington^1*

¹Department of Clinical Haematology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
²Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
³Department of Scienze Mediche, Chirurgiche e Tecnologie Avanzate “G.F. Ingrassia”, University of Catania, Catania, Italy
⁴Guy's and St Thomas' NHS Foundation Trust, London, ENG, United Kingdom

Keiko Maeyama, MD^1*, Yuka Sugimoto, MD, PhD², Keiki Nagaharu, MD, PhD^3*, Eiko Oya, MD^3,4*, Eri Miyata, MD, PhD^5*, Atsushi Fujieda, MD, PhD^6*, Hiroyuki Miyashita, MD, PhD^1*, Takao Sekine, MD, PhD^4*, Shigehisa Tamaki, MD, PhD^6*, Kohshi Ohishi, MD, PhD⁷ and Isao Tawara, MD, PhD³

¹Department of Hematology, Yokkaichi Municipal Hospital, Yokkaichi, Japan
²Department of Hematology and Oncology, Mie University, Tsu City, Mie Prefecture, Japan
³Department of Hematology and Oncology, Mie University Graduate School of Medicine, Tsu, Japan
⁴Department of Hematology, Matsusaka General Hospital, Matsusaka, Japan
⁵Saiseikai Matsusaka General Hospital, Matsusaka City, Mie Pref, JPN
⁶Japanese Red Cross Ise Hospital, Ise City, Mie Pref., JPN
⁷Transfusion Medicine and Cell Therapy, Mie University Hospital, Tsu, Japan

Lucía Pérez-Lamas^1*, Adrian Segura Diaz^2*, Regina García Delgado^3*, Alberto Alvarez-Larran^4,5*, María Alicia Senin^6*, Elvira Mora, MD, PhD^7*, Maria Laura Fox, MD^8*, Irene Pastor Galan^9*, Gemma Azaceta^10*, Sara Garrido Paniagua, MD^11*, Raul Perez Lopez^12*, Diana Margarita Trejos Carvajal^13*, Anna Angona^14*, Carmen Albo Lopez, Hematologist MD, PhD^15*, Pablo Lorente Alegre^16*, Míriam Vara^17*, Juan Antonio Juan Vera Goñi, MD^18*, Dunia De Miguel Llorente^19*, Angeles Fernández Rodríguez^20*, Alberto Marin Sanchez^21*, Adriana Hernando Megido^22*, Maria Teresa Gómez Casares^23*, Ruth Stuckey, PhD^24*, Gonzalo Carreño, PhD^25*, Natalia De Las Heras Rodriguez^26*, Blanca Xicoy, MD^27*, Manuel Perez Encinas, MD^28*, Raquel Mata Serna^29*, Lucia Nuñez Martin-Buitrago^30*, Francisca Ferrer Marin, MD³¹, Neus Amer Salas, MD^32*, Carolina Guillén Rienda^33*, Patricia Velez, MD^34*, Laura Lamarca Eraso^35*, Sandra Martín^36*, Iryna Luts Khoroz^37*, Erik De Cabo López^38*, Angela Gil^39*, Sofía Martín-Consuegra Ramos^40*, Fernando Marco De Lucas, MD, PhD^41*, Maria José Otero Martinez-Fornes^42*, María Luisa Martín Mateos, PhD^43*, Teresa Arquero, MD^44*, Elena Cabezudo Pérez^45*, Luis Antonio López Gómez^46*, Angela Martinez Hellin^47*, Aurelia Tejedor^48*, Esther Herrera de Pablo^49*, Maria Isabel Mata Vazquez^50*, Inmaculada Castillo Valero^51*, Maria Jose Fernández^52*, Carlos Aguilar, MD^53*, Marta Santaliestra^54*, Antonio Garcia Menchon^55*, Begona Navas Elorza, MD^56*, Maria Antonia Duran^57*, María Pérez Sala, MD^58*, Teresa Hernández Santamaría^59*, Mª Ángeles Muñoz Jarreño^60*, Julio Dávila-Valls^61*, Williana Torres Jiménez^62*, Joan Alfons Gonzálvez Fernández^63*, Hugo Alexander Torres Mantilla^64*, Teresa Cobo Rodríguez^65*, Aitor Abuin Blanco, MD^66*, Francisco Pérez, MD^67*, María José Llácer Ferrandis^68*, Paola Beneit Villena^69*, Raisa Peralta^70*, Federico Herrera^71*, Eloi Cañamero Giro^72*, Reyes Jimenez Barcenas^73*, Mercedes Gasior Kabat, MD^74*, Sonia González De Villambrosia^75*, Mariana Teresa Tercero-Mora Rodriguez^76*, Marina Menéndez Cuevas^77*, Beatriz Cuevas Ruiz^78*, Marta Fonseca-Santos^79*, Sonia Garcés Piquer^80*, Rosalía Delapuerta^81*, Alvaro Lorenzo Vizcaya, MD^82*, Juan Carlos Hernandez Boluda, MD, PhD^83* and Valentín García Gutiérrez Sr.⁸⁴

¹Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain
²H. U. Dr. Negrin de GC., LAS PALMAS, Spain
³Hospital Universitario Virgen de la Victoria, MALAGA, Spain
⁴Hematoloy Department,, Hematology Department, Hospital ClíNic, Barcelona, Spain
⁵Hematology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
⁶Institut Català d’Oncologia, Hospital Duran i Reynals. Institut d’Investigació Biomèdica de Bellvitge (IDIBELL). Universitat de Barcelona, Barcelona, Spain
⁷Department of Hematology, Hospital Universitario y Politécnico La Fe, Valencia, Spain
⁸Vall d'Hebron University Hospital, Barcelona, Spain
⁹Department of Hematology, Hospital Clínico Universitario-INCLIVA, Valencia, ESP
¹⁰Hospital Clínico Universitario Lozano Blesa de Zaragoza, Zaragoza, ESP
¹¹Experimental Hematology Unit, Vall d’Hebron Institute of Oncology (VHIO), Vall d'Hebron University Hospital, University Autonoma of Barcelona (UAB), Barcelona, Spain
¹²Hospital Universitario Virgen de la Arrixaca, Murcia, Spain
¹³Hospital General de Castellon, CASTELLON, Spain
¹⁴Hospital Universitario Doctor Josep Trueta - ICO, Girona, Spain
¹⁵Hematology Department, Complexo Hospitalario Universitario de Vigo, Instituto de Investigación Biomédica Galicia Sur (IIBGS)., Vigo, Spain
¹⁶Hospital Arnau de Vilanova, Valencia, Spain
¹⁷Hematology and Hemoterapy Department, Hospital Universitario Cruces, Vizcaya, Spain
¹⁸Hospital Virgen Macarena, SEVILLA, Spain
¹⁹Hospital Universitario de Guadalajara, Guadalajara, Spain, Guadalajara, Spain
²⁰HOSPITAL UNIVERSITARIO CENTRAL DE ASTURIAS, OVIEDO, Spain
²¹Hospital General Universitario De Albacete, Albacete, ESP
²²Hospital Universitario de Cabueñes, GIJÓN, Spain
²³Hospital Universitario Doctor Negrín, Las Palmas, Spain
²⁴Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas De Gran Canaria, Las Palmas, ESP
²⁵Hospital Universitario 12 de Octubre, Madrid, Spain
²⁶Hospital Universitario de León, LEON, ESP
²⁷Hematology Service, ICO-Hospital Germans Trias i Pujol, Institut de Recerca contra la Leucèmia Josep Carreras (IJC), Universitat Autònoma de Barcelona, Badalona, Spain
²⁸Department of Hematology, Hospital Unviersitario de Santiago de Compostela, IDIS, Santiago de Compostela, ESP
²⁹Fundación Jiménez Díaz, MADRID, Spain
³⁰HOSPITAL GENERAL LA MANCHA CENTRO, Ciudad Real, Spain
³¹Hospital Universitario Morales Meseguer. Centro Regional de Hemodonación. Universidad de Murcia. IMIB-Arrixaca, Murcia, Spain
³²Hospital Universitario Son Llàtzer, Palma de Mallorca, Spain
³³Clínica Universidad de Navarra, PAMPLONA, Spain
³⁴Department of Hematology, Hospital del Mar, Barcelona, Spain
³⁵Hospital Santa Ana de Motril, MOTRIL, Spain
³⁶Hematology Department, Hospital Regional Universitario de Málaga, Málaga, Spain
³⁷Hospital Nuestra Señora del Prado, TALAVERA DE LA REINA, ESP
³⁸Hospital del Bierzo, Ponferrada, Spain
³⁹Hospital Universitario de Guadalajara, Guadalajara, Madrid, ESP
⁴⁰Hospital de Alcañiz, TERUEL, Spain
⁴¹Hospital Universitario Basurto, Osakidetza, Bilbao, ESP
⁴²Hospital Gómez Ulla, MADRID, Spain
⁴³Complejo Asistencial Universitario de Salamanca, SALAMANCA, AL, ESP
⁴⁴Fundación Jiménez Díaz, Madrid, Spain
⁴⁵Hospital de San Juan Despí Moisès Broggi, BARCELONA, Spain
⁴⁶Hospital Royo Villanova, ZARAGOZA, Spain
⁴⁷HOSPITAL UNIVERSITARIO CLINICO SAN CECILIO, GRANADA, Spain
⁴⁸Hospital Universitario Santa Lucia, CARTAGENA, Spain
⁴⁹hosptial lluís Alcayís, VALENCIA, Spain
⁵⁰Hospital Costa del Sol, Malaga, ESP
⁵¹HOSPITAL UNIVERSITARIO LA PLANA, VILLARREAL, Spain
⁵²Hospital Universitario Doctor Peset, Valencia, ESP
⁵³Hospital Santa Bárbara, Soria, Spain, Soria, Spain
⁵⁴Hospital Universitari Mútua Terrassa, TARRASA, Spain
⁵⁵Hospital Rafael Méndez, Huercal Overa, ESP
⁵⁶Hospital Clinico San Carlos, Madrid, ESP
⁵⁷Hospital Son Espases, Palma, ESP
⁵⁸Hospital de Elda, ELDA, Spain
⁵⁹HOSPITAL UNIVERSITARIO DONOSTIA, San Sebastián, Spain
⁶⁰Hospital del Henares, MADRID, Spain
⁶¹Hospital Universitario Nuestra Senora de Sonsoles, Avila, ESP
⁶²Hospital Virgen de la luz, CUENCA, Spain
⁶³Hospital General Universitario de Elche, ELCHE, Spain
⁶⁴Hospital Clínico Universitario Virgen de la Victoria, MALAGA, Spain
⁶⁵Hospital Universitario del Sureste, MADRID, Spain
⁶⁶University Hospital of Santiago De Compostela, SANTIAGO DE COMPOSTELA, ESP
⁶⁷Hospital Don Benito-Villanueva, Badajoz, Spain
⁶⁸Hematology, Hospital General Universitario Gregorio Marañón, Madrid, Spain
⁶⁹Hospital San Juan de Alicante, ALICANTE, Spain
⁷⁰CLINICA SAN MIGUEL, PAMPLONA, Spain
⁷¹Hospital Universitario de Getafe, GETAFE, Spain
⁷²Hospital de Mataró, BARCELONA, Spain
⁷³Hospital de la Serranía de Ronda, Ronda, Málaga., Ronda (Málaga), Spain
⁷⁴Hospital La Paz, Madrid, ESP
⁷⁵Hematology Department, Hospital Universitario Marqués de Valdecilla (IDIVAL), Santander, Spain
⁷⁶Hospital Quiron Pozuelo Madrid, POZUELO DE ALARCON, ESP
⁷⁷Hospital Rey Juan Carlos, Madrid, Spain
⁷⁸HOSPITAL UNIVERSITARIO DE BURGOS, Burgos, ESP
⁷⁹Hospital Universitario de Salamanca, Salamanca, ESP
⁸⁰hospital General de Valencia, VALENCIA, Spain
⁸¹HVA, Valencia, ESP
⁸²Hospital Universitario Lucus Augusti, Lugo, Spain
⁸³Hospital Clínico Universitario-INCLIVA, VALENCIA, Spain
⁸⁴Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Universidad de Alcalá, Madrid, Spain

Brynn Parsegov, PA-C¹, Halee Namanny, PharmD^1*, Maren Campbell, PharmD^1*, Yue Zhang, PhD^2*, Feiyun Yan, MS^3*, Michael Christiansen, MA^1*, Amanda Smith, RN^1*, Tsewang Tashi, MD¹ and Josef T. Prchal, MD¹

¹Division of Hematology and Hematologic Malignancies, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT
²University of Utah, Salt Lake City
³University of Utah, Salt Lake City, UT

Long Chang^1*, Luo Wang^2*, Min Lang^1*, Dao-Bin Zhou^1*, Wen Gao³, Minghui Duan^1* and Xin-xin Cao^1*

¹Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
²Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
³Department of Hematology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

Qian Jiang, MD¹, Na Xu^2*, Xiaoli Liu^2*, Li Meng, MD^3*, Suning Chen^4*, Jianyong Li, MD⁵, Linhua Yang^6*, Chun-Yan Chen, MD^7*, Limei Chen, MD^8*, Jie Sun, PhD^9*, Ling Pan^10*, Minghui Duan^11*, Hongmei Jing, MD¹², Jinhai Ren, MD^13*, Fengru Lin, MD^14*, Xuemei Qin^15*, Junqing Xu^16*, Robert Peter Gale, MD¹⁷, Mingfeng Zhao¹⁸, Zhilan Pan, MD^19*, Xianhua Yuan^20*, Lijuan Cui^21*, Zhijian Xiao, MD^22* and Li Weiming^23*

¹National Clinical Research Center for Hematologic Disease, Peking University People’s Hospital, Peking University Institute of Hematology, Beijing, Beijing, China
²Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China
³Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⁴The First Affiliated Hospital of Soochow University, Suzhou, China
⁵First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China
⁶The Second Hospital of Shanxi Medical University, Taiyuan, China
⁷Department of Hematology, Qilu Hospital of Shandong University, Jinan, China
⁸Department of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'An, China
⁹Bone Marrow Transplantation Center of The First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
¹⁰West China Hospital, Sichuan University, Tianjin, AL, China
¹¹Department of Hematology, Peking Union Medical College Hospital, Beijing, China
¹²Department of Hematology, Lymphoma Research Center, Peking University Third Hospital, Beijing, China
¹³The Second Hospital of Hebei Medical University, Shijiazhuang, China
¹⁴The Second Hospital of Hebei Medical University, Shijiazhuang, CHN
¹⁵Department of Hematology, Qilu Hospital, Shandong University, Jinan, China
¹⁶Department of Hematology, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Qingdao, China
¹⁷Centre for Haematology, Department of Immunology and Inflammation, Imperial College of Science, Technology and Medicine, London, United Kingdom
¹⁸Department of Hematology, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China
¹⁹Shijiazhuang People's Hospital, Shijiazhuang, China
²⁰The First Affiliated Hospital of Xingtai Medical College, Xingtai, China
²¹The General Hospital of Ningxia Medical University, Ningxia, CHN
²²Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
²³Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Muhammad Ali Khan, MBBS^1*, Umair Ayub, PhD^1*, Muhammad Umair Anjum, MBBS^1*, Salman Ayub Jajja, MBBS^1*, Syed Arsalan Naqvi, MBBS^1*, Zaryab Bin Riaz^2*, Ammad Raina, DO^3*, Irbaz Bin Riaz, MD, MMSc^1* and Jeanne Palmer, MD⁴

¹Mayo Clinic, Phoenix, AZ
²Rashid Latif Medical College, Lahore, Pakistan
³Canyon Vista Hospital, Sierra Vista, AZ
⁴Mayo Clinic - Arizona, Scottsdale, AZ

Paola Guglielmelli, MD¹, Chiara Maccari^1*, Manjola Balliu, PhD^1*, Giuseppe Gaetano Loscocco, MD^1*, Naseema Gangat, MBBS², Alessandro Atanasio, MD^1*, Paolo Cicogna, MD^1*, Leonardo Signori^1*, Giada Rotunno^1*, Niccolò Bartalucci^1*, Gloria Nanni^3*, Anna Catelani^3*, Rossella Manfredini, PhD, BSc^4*, Chiara Paoli, BSc^1*, Ayalew Tefferi, MD² and Alessandro Maria Vannucchi⁵

¹Department of Experimental and Clinical Medicine, Centro di Ricerca e Innovazione Malattie Mieloproliferative (CRIMM), AOU Careggi, University of Florence, Florence, Italy
²Division of Hematology, Mayo Clinic, Rochester, MN
³University of Florence, Florence, Italy
⁴Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
⁵Department of Experimental and Clinical Medicine, Centro di Ricerca e Innovazione Malattie Mieloproliferative (CRIMM), AOU Careggi, University of Florence, Firenze, Tuscany, Italy

Harinder Gill, MBBS, MD, FRCP (Edin, Glasg, Lond), FRCPath, FHKCP, FHKAM (Medicine)¹, Lester Au^1*, Dorothy Tsai^1*, Rita Yim, PhD^1*, Vivian Li^1*, Paul Lee, PhD^1*, Lynn Chin^1*, Qi Zhang, MD^1*, Garret Man Kit Leung, MBBS, FHKCP, FHKAM^1*, Tony Kwun Yat Wu, BSc, MBBS, MRCP, FHKCP, FHKAM^1* and Hugh Young Rienhoff Jr., MD²

¹Department of Medicine, The University of Hong Kong, Hong Kong, Hong Kong
²Imago BioSciences, Inc., a subsidiary of Merck & Co., Inc., Rahway, NJ

Masooma S Rana, MBBS^1*, Moazah Iftikhar, MBBS^1*, Yamna Jadoon, MBBS², Maymona Abdelmagid, MD^1*, David Viswanatha, MD³, Rong He, MD⁴, Kaaren K. Reichard, MD⁵, Animesh D. Pardanani, MBBS, PhD¹, Naseema Gangat, MBBS⁶ and Ayalew Tefferi, MD⁶

¹Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN
²UMass Chan Medical School Baystate, Broad Brook, CT
³Mayo Clinic, Rochester, MN
⁴Division of Hematopathology, Mayo Clinic, Rochester, MN
⁵Department of Pathology, Mayo Clinic, Rochester, MN
⁶Division of Hematology, Mayo Clinic, Rochester, MN

Maymona Abdelmagid, MD^1*, Jeanne Palmer, MD², Aref Al-Kali, MD³, Mehrdad Hefazi, MD⁴, James M. Foran, MD⁵, Kebede Begna, MD¹, Cecilia Y. Arana Yi, MD⁶, Animesh D. Pardanani, MBBS, PhD¹, Naseema Gangat, MBBS⁴ and Ayalew Tefferi, MD⁴

¹Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN
²Mayo Clinic - Arizona, Scottsdale, AZ
³Mayo Clinic, Rochester, MN
⁴Division of Hematology, Mayo Clinic, Rochester, MN
⁵Division of Hematology & Medical Oncology, Mayo Clinic, Jacksonville, FL
⁶Division of Hematology/Oncology, Mayo Clinic, Scottsdale, AZ

Ji Yun Lee, MD¹, Sung-Eun Lee, MD, PhD^2*, Sung-Soo Yoon, M.D., Ph.D.³, Deok-Hwan Yang, MD, PhD^4*, Sang Kyun Sohn, MD, PhD^5*, Seug Yun Yoon^6*, Soo-Mee Bang, MD, PhD¹, Gyeong Won Lee^7*, Chul Won Choi^8*, Yunsuk Choi, MD, PhD⁹, June-Won Cheong, MD, PhD¹⁰ and Young Hoon Park^11*

¹Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea, Republic of (South)
²Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea, Republic of (South)
³Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of (South)
⁴Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Hwasun, Korea, Republic of (South)
⁵Kyungpook National University Hospital, Daegu, Korea, Republic of (South)
⁶Division of Hematology & Medical Oncology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea, Republic of (South)
⁷Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University College of Medicine, Jinju, Korea, Republic of (South)
⁸Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea, Republic of (South)
⁹Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of (South)
¹⁰Division of Hematology, Department of Internal Medicine, Yonsei University College of Medicine, Severance Hospital, 50 Yonsei-ro, Seodaemun-gu, Seoul, Korea, Republic of (South)
¹¹Ewha Womans University Mokdong Hospital, Seoul, Korea, Republic of (South)

Hannah Goulart, MD¹, Hagop M. Kantarjian, MD², Lucia Masarova, MD², Naval Daver, MD¹, Elias Jabbour, MD³, Tapan M. Kadia, MD², Guillermo Garcia-Manero, MD², Farhad Ravandi, MBBS⁴, Courtney D. DiNardo, MD, MSc⁵, Sherry Pierce, BSN, BA^2*, Lingsha Zhou^6*, Mahesh Swaminathan, MD⁷, Gautam Borthakur, MD⁸, Nitin Jain, MD², Prithviraj Bose, MD³ and Naveen Pemmaraju, MD²

¹MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Leukemia, University of Texas- MD Anderson Cancer Center, Houston, TX
⁵Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX
⁶Department of Leukemia, MD Anderson Cancer Center, Houston
⁷Department of Leukemia, The University of Texas MD Anderson Cancer Center, Missouri City, TX
⁸Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX

Andreas Reiter, MD¹, Jason Gotlib, MD, MS², Iván Álvarez-Twose, MD, PhD^3*, Deepti H. Radia, MD^4*, Johannes Luebke, MD^1*, Priyanka J. Bobbili, ScD, MS^5*, Aolin Wang, PhD^5*, Saša Dimitrijević, PhD^6*, Erin Sullivan, PhD, MPH^7*, Juliana Schwaab, MD^1*, Ilene A. Galinsky, MSN, ANP-C⁸, Cecelia Perkins, MPH^2*, Wolfgang R. Sperr, MD^9,10*, Priya Sriskandarajah, MBBS, MRCP, PhD^4*, Manasi Mohan, MS^5*, Teshawna Badu, MPH^5*, Mei Sheng Duh, ScD, MPH⁵, Peter Valent, MD^9,10 and Daniel J. DeAngelo, MD, PhD⁸

¹Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, Mannheim, Germany
²Stanford Cancer Institute/Stanford University School of Medicine, Stanford, CA
³Institute of Mastocytosis Studies of Castilla La Mancha (CLMast) ─ Spanish Reference Center (CSUR) for Mastocytosis and CIBERONC, Virgen del Valle Hospital, Toledo, Spain
⁴Guy’s & St Thomas’ NHS Foundation Trust of Guy’s Hospital, London, United Kingdom
⁵Analysis Group, Inc., Boston, MA
⁶Blueprint Medicines GmbH, Zug, Switzerland
⁷Blueprint Medicines Corporation, Cambridge, MA
⁸Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
⁹Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria
¹⁰Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria

Rodothea Amerikanou, MD^1*, Tahla Munir, MD PhD^2*, Kristian Bowles, MBBS, PhD^3,4, Christopher McNamara, MD^5*, Nikesh Dhiraj Chavda, MA MBBChir MRCP FRCPath^6*, Azeem Ahmed, MD^7*, Jagdish Adiyodi, MBBS MD FRCP FRCPath^8*, Alasdair Coles, MD PhD^9*, Philippa Kelsey, MBChB MRCP FRCPath^10*, Jeffery Smith, MBChB BMedSci MRCP FRCPath^11*, Richard Adams, BMedSci BMBS MRCP FRCR MD^12*, Hayder KA Hussein, BMedSci BMBS(hons) MRCP FRCPath DipMedEd^13*, Rui Zhao, MD^14*, Amelia Taylor, MD^15*, Trung Nguyen, MD^16*, Satyen Gohil, MD PhD^5* and Matthew Collin, MD, PhD^17,18

¹Cancer Institute, University College London, London, United Kingdom
²Leeds Teaching Hospitals, Leeds, United Kingdom
³Norwich Medical School, University of East Anglia, Norwich, United Kingdom
⁴Norfolk and Norwich University Hospital, Norwich, United Kingdom
⁵University College London Hospitals NHS Foundation Trust, London, United Kingdom
⁶University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom
⁷Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
⁸Royal Blackburn Teaching Hospital, Blackburn, United Kingdom
⁹Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom
¹⁰Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom
¹¹The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool, United Kingdom
¹²University Hospital of Wales, Cardiff, United Kingdom
¹³Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom
¹⁴Torbay Hospital, Torbay and South Devon NHS Foundation Trust, Torbay, United Kingdom
¹⁵Gloucestershire Hospitals NHS Foundation Trust, Gloucester, United Kingdom
¹⁶Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom
¹⁷Newcastle University Translational and Clinical Research Institute, Newcastle Upon Tyne, United Kingdom
¹⁸Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, United Kingdom

Ziyu Wen^1*, Xuan Zhou^2*, Bingyu Lin^1*, Xiaoli Liu^1*, Qiang Wang, MD^1* and Na Xu^1*

¹Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China
²Department of Hematology,Nanfang Hospital, Southern Medical University, Guangzhou, China

Alexandros Rampotas, MBBS, MRCP^1*, Elena Torre^2*, Luke Carter-Brzezinski, MBBChir^3*, Andrea Duminuco^2*, Llywelyn Cadman-Davies^2*, Ashlyn Chee^4*, Fotios Panitsas, MD^5*, Samah Alimam, MD, PhD^6*, Dragana Milojkovic, MBBS, MRCP, FRCPath, PhD^7*, Richard Kaczmarski^8*, Louise Fraser^9*, Rebecca Frewin^10*, Kate Foley^11*, Catherine Hockings^12*, Alesia Khan^13*, Rhys Williams^10*, Jennifer Ryan^14*, Kawai Yip, MD^15*, Kyaw Htin Thaw^16*, Amna Sheikh^16*, Frances Wadelin^17*, Anna L Godfrey^18*, Chun Huat Teh^19*, Andrew J. Wilson^20*, Jonathan Lambert, PhD, BSc, BMBS, FRCP, FRCPath^21*, Adam J Mead, PhD, MRCP, FRCPath²², Donal P McLornan, MD, PhD^23*, Andrew J Innes, MD, PhD^24*, Andrew McGregor^25*, Tim Somervaille, PhD FRCP FRCPath²⁶, Claire Harrison²⁷, Patrick Harrington^16* and Bethan Psaila, MD, PhD^28,29

¹UCL Cancer Institute, University College London, London, United Kingdom
²Haematology Department, Guy's and St Thomas' Hospital NHS Foundation Trust, London, United Kingdom
³Haematology Department, The Christie NHS Foundation Trust, Manchester, United Kingdom
⁴Haematology Department, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
⁵Haematology Department, Laikon General Hospital of Athens, Athens, Greece
⁶University College of London Hospitals NHS Foundation Trust, London, United Kingdom
⁷Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, GBR
⁸Haematology Department, The Hillingdon Hospitals NHS Foundation Trust, London, United Kingdom
⁹Haematology, University Hospitals Dorset NHS Foundation Trust, Dorset, United Kingdom
¹⁰Haematology Department, Gloucestershire Hospitals NHS Foundation Trust, Gloucester, United Kingdom
¹¹Haematology Department, York and Scarborough Teaching Hospitals NHS Foundation Trust, York, United Kingdom
¹²Haematology Department, University Hospitals Dorset NHS Foundation Trust, Dorset, United Kingdom
¹³Haematological Malignancy Diagnostic Service, Leeds Teaching Hospital NHS Trust, Leeds, England, United Kingdom
¹⁴Nottingham University Hospital, Nottingham, United Kingdom
¹⁵Haematology, Dartford and Gravesham NHS Trust, Dartford, United Kingdom
¹⁶Department of Clinical Haematology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
¹⁷Haematology Department, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom
¹⁸Cambridge University Hospitals NHS Trust, Cambridge, United Kingdom
¹⁹Haematology Department, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
²⁰Department of Haematology, University College London Hospital, London, United Kingdom
²¹Department of Haematology, University College Hospital, University College of London Hospitals NHS Foundation Trust, London, United Kingdom
²²Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford, United Kingdom
²³Department of Haematology, University College London Hospitals NHS Trust, London, ENG, United Kingdom
²⁴Centre for Haematology, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom
²⁵Haematology Department, Newcastle Hospitals NHS Foundation Trust, Newcastle, United Kingdom
²⁶The Christie NHS Foundation Trust, Manchester, United Kingdom
²⁷Guy's and St Thomas' NHS Foundation Trust, London, ENG, United Kingdom
²⁸Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, Oxford, ENG, United Kingdom
²⁹Oxford University Hospitals NHS Trust, Oxford, United Kingdom

Saki Ogawa^1*, Kotaro Shide, M.D.¹, Masami Takeuchi, M.D.^2*, Kosei Matsue, M.D., Ph.D.², Takuro Kameda, M.D.¹, Masato Yasumi, M.D., Ph.D.^3*, Takahiro Karasuno, M.D., Ph.D.^3*, Taizo Shimomura, M.D., Ph.D.^4*, Hitoshi Suzushima, M.D.^4*, Kiyoshi Yamashita, M.D.^5*, Noriaki Kawano, M.D., Ph.D.^5*, Osamu Imataki, M.D.^6*, Norimitsu Kadowaki, M.D., Ph.D.⁶, Akihito Yonezawa, MD, PhD^7*, Eiichi Otsuka, M.D.^8*, Yoshio Saburi, M.D.^8*, Yuki Tahira, M.D.^1*, Ayako Kamiunten, M.D.^1*, Keiichi Akizuki, M.D.^1*, Masayoshi Karasawa, M.D.^1*, Ryoma Ikeda, M.D.^1*, Kengo Matsumoto, M.D.^1*, Ayuka Kuroki, M.D.^1*, Koshiro Nagamine, M.D.^1*, Yoko Kubuki, M.D.^1* and Kazuya Shimoda, MD, PhD¹

¹Division of Hematology, Diabetes, and Endocrinology, Department of Internal Medicine, University of Miyazaki, Miyazaki, Japan
²Division of Hematology/Oncology, Kameda Medical Center, Kamogawa, Chiba, Japan
³Rinku General Medical Center, Izumisano, Japan
⁴Kumamoto Shinto General Hospital, Kumamoto, Japan
⁵Miyazaki Prefectural Miyazaki Hospital, Miyazaki, Japan
⁶Kagawa University, Kita-County, Japan
⁷Kokura Memorial Hospital, Kitakyushu, Japan, Kitakyushu, Japan
⁸Oita Prefectural Hospital, Oita, Japan

Lasse Kjær^1*, Morten Kranker Larsen, MSc^1*, Vibe Skov^1*, Trine Alma Knudsen¹, Sabrina Cordua Bech, MD^2*, Jordan A. Snyder^3*, Johanne Gudmand-Høyer^3*, Morten Andersen^4*, Johnny T. Ottesen^4*, Thomas Stiehl^4*, Christina Ellervik^5* and Hans C. Hasselbalch^1*

¹Department of Hematology, Zealand University Hospital, Roskilde, Denmark
²Department of Hematology, Zealand University Hospital, Roskilde, DNK
³Department of Science and Environment, Roskilde University, Roskide, Denmark
⁴Department of Science and Environment, Roskilde University, Roskilde, Denmark
⁵Department of Laboratory Medicine, Boston Children's Hospital, Boston, MA

Lucia Masarova, MD¹, Prithviraj Bose, MD¹, Naveen Pemmaraju, MD¹, Gautam Borthakur, MD¹, Srdan Verstovsek, MD, PhD^2*, C. Cameron Yin, MD, PhD³, Keyur P. Patel, MBBS, PhD³ and Hagop M. Kantarjian, MD¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Kartos Therapeutics, Inc., Redwood City, CA
³Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX

Yile Zhou, MD^1*, Jian Huang, MD, PhD¹, Bingbing Wen^1,2*, Hu Zhou³, Wei Yang^4*, Lianlian Fan^5*, Tiejun Gong^6*, Sujun Gao^7*, Zongjiu Jiao^8*, Qingchi Liu^9*, Lidong Zhao^10*, Guocai Wu^11*, Cuicui Wu^12*, Jun Wang^13*, Jin Zhang^14*, Jiaping Fu^15*, Zengmei Sheng^16*, Zunmin Zhu^17*, Jian Lu^18*, Yi Zhang^1* and Jie Jin¹

¹Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
²The second hospital of shenzhen, Shenzhen, China
³Department of Hematology, Henan Provincial Cancer Hospital, Zhengzhou, China
⁴Department of Hematology, Shengjing Hospital affiliated to China Medical University, Shenyang, China
⁵Deyang People's Hospital, Deyang, China
⁶Institute of Hematology & Oncology, Harbin First Hospital, Harbin, China
⁷The First Hospital of Jilin University, Changchun, China
⁸Xingtai People's Hospital, Xingtai, China
⁹The First Hospital of Hebei Medical University, Shijiazhuang, China
¹⁰The First People’s Hospital of Lianyungang, Lianyungang, Jiangsu, China
¹¹Department of Hematology, Central People’s Hospital of Zhanjiang, Zhanjiang, China
¹²Hematology, Yueyang People's Hospital, HUNAN, China
¹³The First People's Hospital of Changde, Changde, China
¹⁴Department of Hematology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
¹⁵Department of Hematology, Shaoxing People's Hospital (Shaoxing Hospital of Zhejiang University), Shaoxing, Zhejiang Province, China
¹⁶The Third Hospital Changsha, Changsha, Hunan, China
¹⁷Henan Provincial People's Hospital, Zhengzhou, China
¹⁸Hangzhou Biosun Pharmaceutical Co., LTD, Hangzhou, Zhejiang, China