Jorge E. Cortes, MD¹, Delphine Rea², Michael J. Mauro, MD³, Andreas Hochhaus, MD⁴, Dong-Wook Kim, MD, PhD⁵, Koji Sasaki, MD⁶, Fabian Lang^7*, Michael C. Heinrich, MD^8*, Massimo Breccia^9*, Michael W. Deininger, MD, PhD¹⁰, Yeow Tee Goh, MD¹¹, Jeroen J.W.M. Janssen¹², Moshe Talpaz, MD¹³, Valle Gomez G De Soria, MD^14*, Philipp le Coutre, MD^15*, Francois-Xavier Mahon, MD, PhD¹⁶, Daniel Deangelo, MD, PhD^17*, Shruti Kapoor, PhD^18*, Gessami Sanchez-Olle^19*, Meng Cao, PhD^18*, Nithya Agrawal, MD^18* and Timothy P Hughes, MD, MBBS, FRACP, FRCPA²⁰

¹Georgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA
²Department of Hématologie, Hôpital Saint-Louis, Paris, France
³Myeloproliferative Neoplasms Program, Memorial Sloan Kettering Cancer Center, New York, NY
⁴Hematology/Oncology, Universitätsklinikum Jena, Jena, Germany
⁵Uijeongbu Eulji Medical Center, Uijeoungbu, Korea, Republic of (South)
⁶Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁷Department of Hematology/Oncology, Goethe University Hospital, Goethe University Hospital, Frankfurt/M, Germany
⁸Portland VA Health Care System and OHSU Department of Medicine, Division of Hematology and Oncology, Knight Cancer Institute, Portland, OR
⁹Department of Translational and Precision Medicine, Az., Hematology-Sapienza University, Rome, Italy
¹⁰Versiti Blood Research Institute, Milwaukee, WI
¹¹Department of Haematology, Singapore General Hospital, Singapore, Singapore
¹²Radboud University Medical Center, Nijmegen, Netherlands
¹³Division of Hematology-Oncology, University of Michigan Rogel Cancer Center, Ann Arbor, MI
¹⁴Hospital Universitario La Princesa, Madrid, Spain
¹⁵Department of Oncology and Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany
¹⁶Department of Hematology, Institut Bergonié, Bordeaux, Bordeaux, France
¹⁷Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
¹⁸Novartis Pharmaceuticals Corporation, East Hanover, NJ
¹⁹Novartis Pharma AG, Basel, Switzerland
²⁰South Australian Health and Medical Research Institute and University of Adelaide, Adelaide, SA, Australia

Susanne Isfort^1,2,3*, Kirsi Manz, PhD^2,4,5,6*, Lino L. Teichmann, MD^7,8*, Martina Crysandt, MD^3,9*, Andreas Burchert, MD¹⁰, Andreas Hochhaus, MD¹¹, Susanne Saussele, MD¹², Alexander Kiani, MD^13,14*, Joachim R. Goethert, MD¹⁵, Thomas Illmer, MD^16*, Philippe Schafhausen^17*, Haifa Kathrin Al-Ali^18*, Frank Stegelmann, MD^19*, Mathias Hänel, MD²⁰, Tim Pfeiffer^21*, Aristoteles Giagounidis, MD²², Georg-Nikolaus Franke, MD^23*, Steffen Koschmieder, MD^3,9, Alice Fabarius, PhD^12*, Thomas Ernst, MD²⁴, Mareille Warnken-Uhlich^25*, Denise Kohn^6*, Markus Pfirrmann, PhD^6*, Dominik Wolf, M.D.^7,8,26,27* and Tim H. H. Brummendorf, MD^3,9,27

¹Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School (MHH), Hannover, Germany
²shared first authorship, Hannover, Germany
³Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Faculty of Medicine, University Hospital RWTH Aachen, Aachen, Germany
⁴Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
⁵Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School (MHH), Hannover, AL, Germany
⁶Institut für Medizinische Informationsverarbeitung, Biometrie und Epidemiologie (IBE), Ludwig-Maximilians-Universität, München, Germany
⁷Department of Medicine III, University Hospital Bonn, Bonn, Germany
⁸Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Bonn, Germany
⁹Center for Integrated Oncology Aachen-Bonn-Cologne-Düsseldorf (CIOABCD), Aachen, Germany
¹⁰Department of Hematology, Oncology and Immunology, University Hospital Marburg, Marburg, Germany
¹¹Hematology and Oncology, Comprehensive Cancer Center Central Germany – Campus Jena, Klinik für Innere Medizin II, Jena, Germany
¹²Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, Mannheim, Germany
¹³Department of Hematology and Oncology, Klinikum Bayreuth, Bayreuth, Germany
¹⁴Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Erlangen, Germany
¹⁵Department of Hematology and Stem Cell Transplantation, West German Cancer Center (WTZ), University Hospital Essen, Essen, Germany
¹⁶Hematology Private Practice, Dresden, Germany
¹⁷Department of Oncology, Hematology and Bone Marrow Transplantation with Section of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
¹⁸Krukenberg Cancer Center Halle, Universitätsmedizin Halle, Halle (saale), Germany
¹⁹University Hospital of Ulm, Department of Internal Medicine III, Ulm, Germany
²⁰Department of Internal Medicine III, Klinikum Chemnitz, Chemnitz, Germany
²¹Department of Hematology and Oncology, Klinikum Augsburg, Augsburg, Germany
²²Clinic for Hematology, Oncology and Palliative Care Marien Hospital Düsseldorf, Dusseldorf, Germany
²³Department of Hematology, Cellular Therapy, Hemostaseology and Infectious Diseases, University Leipzig Medical Center, Leipzig, Germany
²⁴Jena University Hospital, Jena, Germany
²⁵Clinical Study Core Unit Bonn, Institute of Clinical Chemistry and Clinical Pharmacology, University Bonn, Bonn, Germany
²⁶University Hospital of Internal Medicine V (Hematology and Oncology), Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria
²⁷Shared senior authorship, Bonn, Germany

Mengyao Yuan^1*, Li Zhou, MD^2*, Xin Du, PhD³, Jianyu Weng, MD, PhD^4*, Linhua Yang^5*, Yanping Ma^5*, Shasha Zhao^6*, Zhenfang Liu, MD^7*, Qin Wen, MD^8*, Qingxian Bai^9*, Xianqi Feng^10*, Yanqiu Han^11*, Aifang Li^12*, Chunshui Liu^13*, Qing Leng^14*, Li Meng, MD^15*, Baohong Wang, MD^16*, Xuehong Ran, MD^16*, Xiaodong Wang^17*, Haiguo Zhang^18*, Yun Zeng^19*, Yanli Zhang, MD^20* and Qian Jiang, MD²¹

¹Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing, China, Beijing, China
²Ruijin Hospital, Shanghai Jiaotong University School Of Medicine, West Roxbury, MA
³Department of Hematology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, WA, China
⁴Guangdong Provincial People's Hospital, Guangdong, China
⁵Department of Hematology, The Second Hospital of Shanxi Medical University, Taiyuan, China
⁶Peking University People’s Hospital, Qingdao, China
⁷The First Affiliated Hospital of Guangxi Medical University, Nanning, China
⁸Xinqiao Hospital, Army Medical University, Chongqing, China
⁹Xijing Hospital, Air Force Medical University, Xi'An, China
¹⁰Department of Hematology, The Affiliated Hospital of Qingdao University, qingdao, China
¹¹The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China
¹²Baoshan People's Hospital, Baoshan, China
¹³Department of Hematology, The First Hospital of Jilin University, Changchun, China
¹⁴Anshan Central Hospital, Anshan, China
¹⁵Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
¹⁶Department of Hematology, Weifang People's Hospital, Weifang, CHN
¹⁷Department of Hematology, Sichuan Academy of Medical Sciences Sichuan Provincial, Sichuan, CHN
¹⁸Jining NO.1 People's Hospital, Jining, CHN
¹⁹Department of Hematology, First Affiliated Hospital of Kunming Medical Universit, Kuming, CHN
²⁰Department of Hematology, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China
²¹Peking University People’s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China

May Chiu¹, Maria Agustina Perusini², Jaeyoon John Kim^2*, Danielle Pyne^1*, Muzaffar Bhatti¹, Anthea Travas^1*, Oyeronke Ayansola^1*, Amirtha Ambalavanan^1*, Jenny Ho^3* and Dennis Dong Hwan Kim, MD, PhD²

¹Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre/University Health Network, Toronto, ON, Canada
²Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
³Department of Medicine, Division of Hematology, London Health Science Centre, London, ON, Canada

Shiwei Hu^1*, Xiudi Yang, MD^1*, Dijiong Wu, MD, PhD², Yi Wang^3*, Xiaoqiong Zhu^4*, Weiying Feng^5*, Huafeng Wang^6* and Jian Huang, MD, PhD⁷

¹Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
²Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China
³Department of Hematology, The First Affiliated Hospital of Ningbo University, Ningbo, China
⁴Department of Hematology, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, China
⁵Department of Hematology, Shaoxing People’s Hospital, Shaoxing, China
⁶The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
⁷Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

Tian Zeng^1*, Xiudi Yang, MD^1*, Yi Wang^2*, Dijiong Wu, MD, PhD³, Weiying Feng^4*, Ying Lu^5*, Huafeng Wang^6* and Jian Huang, M.D.^1*

¹Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
²Department of Hematology, The First Affiliated Hospital of Ningbo University, Ningbo, China
³Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China
⁴Department of Hematology, Shaoxing People’s Hospital, Shaoxing, China
⁵Department of Hematology, The Affiliated People's Hospital of Ningbo University, Ningbo, China
⁶The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China

Melanie T Rebechi, MD^1,2, Quihong Zhao^1,2*, Michael Marcucci^1,2*, Nidhi Sharma, PhD^1,3*, Allyson Waller, PharmD, BCOP^1,4*, Marvellous Olowookere^5*, Alyssa Swank^5*, Christian Hu^5*, Alice Mims, MD^1,6 and Jennifer E. Vaughn, MD, MPH^1,2

¹The James Comprehensive Cancer Center, Columbus, OH
²Division of Hematology, The Ohio State University Medical Center, Columbus, OH
³Division of Hematology, Ohio State University Medical Center, Columbus, OH
⁴Department of Pharmacy, The James Cancer Hospital and Solove Research Institute at The Ohio State University, Columbus, OH
⁵School of Pharmacy, The Ohio State University, Columbus, OH
⁶The Ohio State University Comprehensive Cancer Center, Columbus, OH

Roberto Latagliata^1*, Isabella Capodanno, MD^2*, Maria Cristina Miggiano^3*, Cristina Bucelli, MD^4*, Sabrina Leonetti Crescenzi, MD^5*, Sabina Russo, MD^6*, Ida Carmosino, MD^7*, Atelda Romano, MD^8*, Federica Sorà^9*, Massimiliano Bonifacio, MD^10*, Luigiana Luciano, MD¹¹, Giovanni Caocci, MD¹², Giuseppina Loglisci, MD^13*, Chiara Elena^14*, Francesca Lunghi^15*, Rikard Mullai, MD^16*, Immacolata Attolico^17*, Gianni Binotto, MD^18*, Elena Crisà, MD^19*, Paolo Sportoletti^20*, Francesco Cavazzini, MD^21*, Ambra Di Veroli, MD^22*, Anna Rita Scortechini, MD^23*, Anna Paola Leporace, MD^24*, Alessandro Maggi, MD^25*, Monica Crugnola, MD^26*, Fabio Stagno, MD, PhD²⁷, Marco Santoro^28*, Pamela Murgano, MD^29*, Davide Rapezzi, MD^30*, Debora Luzi, MD^31*, Jolanda Donatella Vincelli, MD^32*, Sara Galimberti, MD^33*, Monica Bocchia, MD^34*, Carmen Fava, MD, PhD^35*, Alessandra Malato^36*, Elisabetta Abruzzese, MD³⁷, Michele Pizzuti, MD^38*, Alessandra Iurlo, MD, PhD^39*, Giuseppe Saglio, MD⁴⁰, Giorgina Specchia, MD, PhD⁴¹, Massimo Breccia^42* and Mario Tiribelli, MD^43*

¹Hematology Unit, Ospedale Belcolle, Viterbo, Italy, Rome, ITA
²hematology, AUSL Reggio Emilia, Reggio Emilia, Italy
³Hematology Department, San Bortolo Hospital, Vicenza U.O.C. di Ematologia, Vicenza, ITA
⁴FONDAZIONE IRCCS CA' GRANDA OSPEDALE MAGGIORE POLICLINICO, MILANO, Italy
⁵Division of Hematology, Azienda Ospedaliera San Giovanni Addolorata, Roma, Italy
⁶Division of Hematology, Dipartimento di Patologia Umana dell'Adulto e dell'Età Evolutiva,, Hematology Section, AOU Policlinico "G Martino", University of Messina, Italy, Messina, Italy
⁷Hematology, Department of Translational and Precision Medicine, Azienda Ospedaliera Policlinico Umberto I, Sapienza University of Rome, Rome, Italy
⁸IRCCS Regina Elena National Cancer Institute, Rome, ITA
⁹Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
¹⁰Department of Engineering for Innovation Medicine, Section of Innovation Biomedicine, Hematology Area, University of Verona, Verona, Italy
¹¹Hematology Unit, Federico II University, Napoli, Italy
¹²University of Cagliari, Monserrato, Italy
¹³Hematology, Vito Fazzi Hospital, Lecce, Lecce, ITA
¹⁴U.O.C Ematologia 1, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
¹⁵Division of Hematology and BMT, IRCCS San Raffaele Hospital, Milan, Italy, Milan, Italy
¹⁶Division of Hematology and BMT, Department of Medical Area, University of Udine, Udine, Udine, Italy
¹⁷University of Bari, Department of Emergency and Organ Transplantation (D.E.T.O.), Hematology Section, Bari, Bari, Italy
¹⁸Department of Medicine, Hematology and Clinical Immunology, University of Padua, Padua, Italy
¹⁹Hematology, Ospedale Maggiore, Novara, Italy
²⁰Department of Medicine and Surgery, Institute of Hematology, Centro di Ricerca Emato Oncologica (CREO), University of Perugia, Perugia, Italy
²¹Division of Hematology, Arcispedale Sant'Anna, University of Ferrara, Ferrara, ITA
²²Hematology, Belcolle Hospital, Viterbo, Italy
²³Division of Hematology, Department of Molecular and Clinical Sciences, University of Marche, Ancona, Italy, Ancona, Italy
²⁴23. Hematology Unit Azienda Ospedaliero Universitaria Sant'Andrea, Rome, Rome, Italy
²⁵Division of Hematology and Bone Marrow Transplant, Ospedale S.G. Moscati, Taranto, Italy
²⁶Hematology Unit and BMT, University Hospital of Parma, Parma, Italy
²⁷Hematology Section, Biomedical Sciences, Trecastagni, Catania, Italy
²⁸Hematology Unit, University Hospital "Paolo Giaccone", Palermo, Italy
²⁹Division of Hematology, Sant'Elia Hospital, Caltanissetta, Caltanissetta, Italy
³⁰Department of Hematology, S. Croce e Carle Hospital, Cuneo, Italy
³¹Onco-Hematology Department, AO Santa Maria, Terni, Terni, Italy
³²Hematology Unit, Hemato-Oncology and Radiotherapy Department, Grande Ospedale Metropolitano "Bianchi-Melacrino-Morelli", 89124 Reggio Calabria, RC, Italy, REGGIO CALABRIA, Italy
³³Department of Clinical and Experimental Medicine, Hematology, University of Pisa, Pisa, Italy
³⁴Hematology, Azienda Ospedaliera Universitaria Senese, University of Siena, Siena, Italy
³⁵Hematology, Mauriziano Hospital, Torino, Turin, Italy
³⁶Hospital Riuniti Villa Sofia Cervello, Palermo, Italy
³⁷Department of Hematology, S. Eugenio Hospital, Tor Vergata University, ASL Roma 2, Roma, I, Italy
³⁸Department of Onco-Hematology, “San Carlo” Regional Hospital, Potenza, Italy
³⁹Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy
⁴⁰Dept. of Clinical and Biological Sciences, University of Turin, Turin, Italy
⁴¹Former Full Professor of Hematology, University of Bari, Bari, Italy
⁴²Department of Translational and Precision Medicine, Az., Hematology-Sapienza University, Rome, Italy
⁴³Division of Hematology and BMT, Department of Medical Area, University of Udine, Udine, Italy

Zherou He, MBBS^1,2*, Qing Zhang^1*, Xuan Zhou^3*, Qiang Wang, MD^1*, Xiaoli Liu^1* and Na Xu^1*

¹Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China
²Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, AL, China
³Department of Hematology,Nanfang Hospital, Southern Medical University, Guangzhou, China

Thomas Ernst, MD¹, Jenny Rinke, PhD^2*, Philipp le Coutre, MD^3*, Martina Crysandt, MD^4*, Tim H. H. Brummendorf, MD⁵, Andreas Burchert, MD⁶, Fabian Lang, MD^7*, Susanne Saussele, MD⁸, Markus Pfirrmann, PhD^9*, Thomas Lang, MSc^9*, Christian Fabisch, PhD^2* and Andreas Hochhaus, MD¹⁰

¹Jena University Hospital, Jena, Germany
²Hematology/Oncology, Jena University Hospital, Jena, Germany
³Department of Oncology and Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany
⁴Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Faculty of Medicine, University Hospital RWTH Aachen, Aachen, Germany
⁵Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, University Medical Center Aachen, Aachen, Germany
⁶Department of Hematology, Oncology and Immunology, University Hospital Marburg, Marburg, Germany
⁷Hematology/Oncology, Klinikum der Goethe Universität, Frankfurt/Main, Germany
⁸III. Medizinische Klinik, Medizinische Fakultät Mannheim der Universität Heidelberg, Mannheim, Germany
⁹Institut für Medizinische Informationsverarbeitung, Biometrie und Epidemiologie (IBE), Ludwig-Maximilians-Universität, München, Germany
¹⁰Hematology and Oncology, Comprehensive Cancer Center Central Germany – Campus Jena, Klinik für Innere Medizin II, Jena, Germany

Yingling Zu^1*, Huifang Zhao^2*, Jianling Chen^3*, Huibing Dang^4*, Yanrong Shi^5*, Lixin Liang^6*, Shuhao Mei^7*, Wenyi Lu⁸, Jian Zhou, MD, PhD^9*, Yongping Song^10* and Yanli Zhang, MD^2*

¹Department of Hematology, Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, zhengzhou, China
²Department of Hematology, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China
³Department of Hematology, Pingdingshan the Second People’s Hospital, pingdingshan, China
⁴Department of Hematology, The First Affiliated Hospital of Nanyang Medical College, nanyang, China
⁵Department of Hematology, General Hospital of Pingmei Shenma Medical Group, pingdingshan, China
⁶Department of Hematology, Sanmenxia Central Hospital, sanmenxia, China
⁷Department of Hematology, Xuchang Central Hospital, xuchang, China
⁸Department of Hematology, Henan Provincial People's Hospital, zhengzhou, China
⁹Department of Hematology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China
¹⁰Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

Vitida Chuengviroj, MD^*, Piangrawee Niprapan^*, Teerachat Punnachet, M.D.^*, Nonthakorn Hantrakun, M.D.^*, Sasinee Hantrakool, M.D.^*, Thanawat Rattanathammethee, M.D.^*, Chatree Chai-Adisaksopha, M.D., Ph.D.^*, Ekarat Rattarittamrong, M.D.^*, Adisak Tantiworawit, M.D., Lalita Norasetthada, MD and Pokpong Piriyakhuntorn, M.D.^*

Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

Hadil Zureigat, MD¹, Ahmed N Mohamed, MD^2*, Muaz Alsabbagh Alchirazi, MD^3*, Parker Foster, MD^4*, Yasmine Elghoul, MD^4*, Aastha Dhakal, MD^1*, Ali Mushtaq, MD^1*, Naveen Rehman, MD^1*, Bryan Berube, MD^1*, Diego Ramonfaur, MD, MSc, MPH^5*, Brandon Francis, MD^4*, Sneha Govande, PhD^6*, Emily C. Zabor, DrPH^7*, Akriti G. Jain, MD⁸, John C. Molina, MD, MEd⁹, Sophia Balderman, MD^8*, Abhay Singh, MD, MPH⁸, Aaron T. Gerds, MD, MS⁸, Anjali S. Advani, MD⁸, Hetty E. Carraway, MD, MBA⁸, Matt Kalaycio, MD⁸, Sudipto Mukherjee, MD, PhD, MPH⁸, Rohit Moudgil, MD, PhD^10* and Moaath K. Mustafa Ali, MD, MPH⁸

¹Department of Internal Medicine, Cleveland Clinic, Cleveland, OH
²Department of Internal Medicine, Cleveland Clinic, South Euclid, OH
³Lerner Research Institute, Cleveland Clinic, Cleveland, OH
⁴Internal Medicine, Cleveland Clinic, Cleveland, OH
⁵Cleveland Clinic, Cleveland, OH
⁶Department of Quantitative Health Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, OH
⁷Department of Quantitative Health Sciences, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH
⁸Department of Hematology and Medical Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH
⁹Pediatric Oncology Branch, National Cancer Institute, Shaker Heights, OH
¹⁰Cardiovascular Medicine Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH

Selene Grano, MD^1*, Valentina Bonuomo, MD^2*, Emanuele Koumantakis, MD^3*, Paola Berchialla, PhD^4*, Fausto Castagnetti, MD, PhD^5,6, Massimo Martino, MD^7*, Chiara Elena, MD^8*, Monica Bocchia, MD^9*, Isabella Capodanno, MD^10*, Tamara Intermesoli^11*, Maria Cristina Miggiano^12*, Carlo Gambacorti-Passerini, MD, Prof.¹³, Alessandra Iurlo, MD, PhD^14*, Francesca Lunghi^15*, Luigiana Luciano, MD¹⁶, Elisabetta Abruzzese, MD¹⁷, Angelo Michele Carella, MD^18*, Massimo Breccia^19*, Felicetto Ferrara, MD^20*, Sabrina Leonetti Crescenzi, MD^21*, Barbara Scappini^22*, Marco De Gobbi, MD, PhD^23*, Federica Sorà^24*, Davide Rapezzi, MD^25*, Debora Luzi, MD^26*, Sara Galimberti, MD^27*, Monica Crugnola, MD^28*, Anna Rita Scortechini, MD^29*, Alessandro Maggi^30*, Massimiliano Bonifacio, MD^31*, Mario Annunziata, MD^32*, Giovanni Caocci, MD³³, Germana Beltrami, MD^34*, Francesco Cavazzini, MD^35*, Giuseppe Pietrantuono, MD^36*, Leonardo Campiotti^37*, Fabio Stagno, MD, PhD³⁸, Caterina Musolino^39* and Carmen Fava, MD, PhD^40*

¹Department of Molecular Biotechologies and Health Sciences, University of Torino, Turin, ITA
²Department of Clinical and Biological Sciences, University of Turin, Torino, Italy
³Dipartimento di Scienze della Sanità Pubblica e Pediatriche, Università degli Studi di Torino, Torino, Italy
⁴Department of Clinical and Biological Sciences, University of Torino, Orbassano, Italy
⁵Department of Medical and Surgical Sciences, Institute of Hematology “Seràgnoli”, University of Bologna, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
⁶Dipartimento di Scienze Mediche e Chirurgiche (DIMEC), Università di Bologna, Bologna, Italy
⁷Centro Unico Trapianti A, Grande Ospedale Metropolitano Bianchi Melacrino Morelli, Reggio Calabria, Italy
⁸U.O.C Ematologia 1, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
⁹Hematology Unit, Azienda Ospedaliera Universitaria Senese, University of Siena, Siena, Siena, Italy
¹⁰hematology, AUSL Reggio Emilia, Reggio Emilia, Italy
¹¹Hematology and Bone Marrow Transplant Unit, Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy
¹²Hematology Department, San Bortolo Hospital, Vicenza U.O.C. di Ematologia, Vicenza, ITA
¹³Department of Medicine and Surgery, University Milano-Bicocca, Monza, Italy
¹⁴Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy
¹⁵San Raffaele Institute Milano Italy, Milano, ITA
¹⁶Hematology Unit, Federico II University, Napoli, Italy
¹⁷Department of Hematology S. Eugenio Hospital, Rome, Italy, Roma, Italy
¹⁸Hematology and Bone Marrow Transplant Unit, IRCCS Fondazione Casa Sollievo della Sofferenza San Giovanni Rotondo, Foggia, Italy, San Giovanni Rotondo, Italy
¹⁹Department of Translational and Precision Medicine, Az., Hematology-Sapienza University, Rome, Italy
²⁰Division of Hematology, AORN Cardarelli, Naples, Napoli, Italy
²¹Division of Hematology, Azienda Ospedaliera San Giovanni Addolorata, Roma, Italy
²²Hematology Unit, Hematology Unit, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy
²³Department of Clinical and Biological Sciences, Department of Clinical and Biological Sciences, University of Turin, Orbassano, ITA
²⁴Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
²⁵Department of Hematology, S. Croce e Carle Hospital, Cuneo, Italy
²⁶Onco-Hematology Department, AO Santa Maria, Terni, Terni, Italy
²⁷Department of Clinical and Experimental Medicine, Hematology, University of Pisa, Pisa, Italy
²⁸Hematology Unit and BMT Center Azienda Ospedaliero Universitaria Parma, Parma, Italy
²⁹Division of Hematology, Department of Molecular and Clinical Sciences, University of Marche, Ancona, Italy, Ancona, Italy
³⁰Haematology division, Ospedale S.G. Moscati, Taranto, Italy
³¹Department of Engineering for Innovation Medicine, Section of Innovation Biomedicine, Hematology Area, University of Verona, Verona, Italy
³²Hematology, San Giuseppe Moscati Hospital, Aversa, Italy
³³Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy
³⁴U.O. Ematologia e terapie cellulari, IRCCS Azienda Ospedaliera Universitaria San Martino, Genova, Italy
³⁵Division of Hematology, Arcispedale Sant'Anna, University of Ferrara, Ferrara, ITA
³⁶Hematology and Stem Cell Transplantation Unit, IRCCS Centro Oncologico della Basilicata, Rionero in Vulture, Italy
³⁷Department of Medicine and Surgery, University of Insubria, Varese, ITA
³⁸Division of Hematology, AOU Policlinico “G. Martino”, University of Messina, Italy, Catania, Italy
³⁹Division of Hematology, Department of Human Pathology in Adulthood and Childhood, University of Messina, Messina, Italy
⁴⁰Department of Clinical and Biological Sciences, University of Turin, Torino, Italy, Orbassano, To, Italy

Sewon Lee, MD¹, Yeung-Chul Mun, MD, PhD^2*, Hongtae Kim, Ph.D^3*, Sung-Ho Park^3*, Semin Lee^4*, Seunghoon Kim^4*, Sung-Hyun Kim, MD^5*, Young Rok Do, MD, PhD⁶, Soo-Hyun Kim^7*, Kyung-Mi Kee^7*, Yoonsung Lee^8* and Dong-Wook Kim, MD, PhD^7,9

¹Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, AL, South Korea
²Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Korea, Republic of (South)
³Department of Biological Science, Ulsan National Institute of Science & Technology, Ulsan, Korea, Republic of (South)
⁴Department of Biomedical Engineering, College of Information-Bio Convergence Engineering, Ulsan National Institute of Science and Technology, Ulsan, Korea, Republic of (South)
⁵Department of Internal Medicine, Dong-A University Medical Center, Busan, Korea, Republic of (South)
⁶Department of Hemato-Oncology, Dongsan Medical Center, Keimyung University, Daegu, Korea, Republic of (South)
⁷Leukemia Omics Research Institute, Eulji University, Uijeongbu, Korea, Republic of (South)
⁸Clinical Research Institute, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University, Seoul, Korea, Republic of (South)
⁹Uijeongbu Eulji Medical Center, Uijeoungbu, Korea, Republic of (South)

Mikko Purhonen, MSc^1*, Mikael Tatun, MSc^1*, Kevin Hung, MBBS, FRACP, FRCPA², Oda Tafjord^3*, Shady Adnan-Awad, M.D., Ph.D^4,5,6*, Perttu Koskenvesa, MD^7*, Sanna Siitonen, MD, PhD^1,8*, Kimmo Porkka, MD, PhD^1,9,10,11, Satu Mustjoki, MD, PhD^4,10,11, Signe Danielsson^12*, Henrik Hjorth-Hansen, M.D., Ph.D.^3,13, Ulla Olsson-Strömberg, M.D., Ph.D.^14*, Takashi Kumagai, MD, PhD^15*, Shinya Kimura, MD, PhD¹⁶, David M Ross, MD, PhD, FRACP, FRCPA^17,18* and Oscar E. Brück, MD, PhD^1*

¹Hematoscope Lab, Comprehensive Cancer Center & Center of Diagnostics, Helsinki University Hospital, Helsinki, Finland & Department of Oncology, University of Helsinki, Helsinki, Finland
²Royal Adelaide Hospital, Adelaide, SA, Australia
³Department of Hematology, St. Olavs Hospital, Trondheim, Norway, Trondheim, Norway
⁴Translational Immunology Research program, University of Helsinki, Helsinki, Finland, Helsinki, Finland
⁵Hematology Research Unit Helsinki, Department of Hematology, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland, Helsinki, Finland
⁶ICAN Digital Precision Cancer Medicine Flagship, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland, Helsinki, Finland
⁷Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland, Helsinki, Finland
⁸Department of Clinical Chemistry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
⁹Translational Immunology Research Program, University of Helsinki, Helsinki, Finland
¹⁰Hematology Research Unit Helsinki, Department of Hematology, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland
¹¹ICAN Digital Precision Cancer Medicine Flagship, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland
¹²Medicinska kliniken, Universitetssjukhuset, Orebro, Sweden, Orebro, Sweden
¹³Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway, Trondheim, Norway
¹⁴Department of Medical Science and Division of Hematology, University Hospital, Uppsala, Sweden, Uppsala, Sweden
¹⁵Department of Hematology, Ome Medical Center, Ome-Shi, Tokyo, Japan, Oume-Shi, Japan
¹⁶Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan, Saga, Japan
¹⁷Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia, Adelaide, Australia
¹⁸Department of Haematology, Flinders University and Medical Centre, Adelaide, SA, Australia, Adelaide, Australia