Junji Koya^1*, Tomohiko Tanigawa^1*, Kota Mizuno, MD^1*, Haryoon Kim^1*, Yuta Ito^1*, Mitsuhiro Yuasa, MD^1*, Kentaro Yamaguchi^1*, Yasunori Kogure, MD, PhD^1*, Yuki Saito^1*, Sumito Shingaki, MD^1*, Mariko Tabata^1*, Koichi Murakami, MD, PhD^1*, Kenichi Chiba, PhD^2*, Ai Okada^2*, Yuichi Shiraishi, PhD^2*, Amira Marouf^3*, Raphaël Liévin, MD^4*, Sammara Chaubard^5*, Arnaud Jaccard, MD, PhD^5*, Olivier Hermine, MD, PhD⁶, Laurence de Leval, MD, PhD⁷, Olivier Tournilhac^8*, Gandhi Damaj, MD, PhD^9*, Philippe Gaulard, MD^10*, Lucile Couronne^11*, Teruhito Yasui^12*, Kazutaka Nakashima^13*, Hiroaki Miyoshi, MD, PhD^13*, Koichi Ohshima, MD, PhD^13* and Keisuke Kataoka, MD, PhD¹

¹Division of Molecular Oncology, National Cancer Center Research Institute, Tokyo, Japan
²Division of Genome Analysis Platform Development, National Cancer Center Research Institute, Tokyo, Japan
³INSERM UMR U1163—Imagine Institute, Paris, France
⁴INSERM U1163 Laboratory of molecular mechanisms of hematological disorders and therapeutic implications, Institut IMAGINE, Université Paris Cité, Paris, France
⁵Limoges University Hospital, Limoges, France
⁶Laboratory of physiopathology of hematological disorders and their therapeutic implications, IMAGINE institute Paris France, Paris, France
⁷Hôpital Universitaire de Lausanne, Lausanne, Switzerland
⁸CHU Estaing, Clermont-Ferrand University Hospital, CLERMONT FERRAND, AURA, France
⁹CHU Caen, Caen, Normandy, FRA
¹⁰Hôpital Henri Mondor, Créteil, France
¹¹Laboratory of cellular and molecular mechanisms of hematological disorders and therapeutic implications, INSERM U1163, Imagine Institute, Paris City University, Paris, France
¹²National Institutes of Biomedical Innovation, Health, and Nutrition, Osaka, JPN
¹³Department of Pathology, Kurume University School of Medicine, Kurume, Japan

Maxime Battistella^1*, Alejandro A. Gru, MD^2*, Hélène Moins-Teisserenc, MD, PhD^3*, Martine Bagot, MD, PhD^4*, Youn-H H. Kim, MD⁵, Larisa J Geskin, MD^6*, Pablo L Ortiz-Romero, MD, PhD^7*, Ellen Kim, MD^8*, Neha Mehta-Shah, MD⁹, Olivier Dereure, MD, PhD^10*, Saskia Oro, MD^11*, Lubomir Sokol, MD, PhD¹², Marie Beylot-Barry, MD, PhD^13*, Stéphane Dalle, MD, PhD^14*, Eric D. Jacobsen, MD¹⁵, Frederick Lansigan, MD^16*, Caroline Ram-Wolff, MD^17*, Michael S. Khodadoust, MD, PhD¹⁸, Pier Luigi Zinzani, MD, PhD¹⁹, Julien Viotti^20*, David Magrez^20*, Agnes Boyer Chammard^20*, Constance Vagne^20*, Flavien Carraguel^20*, Laura Assante Miranda^20*, Valentine Peri^20*, Sivan Bokobza^20*, Marie-Laure Thibult, PH.D^20*, Cécile Bonnafous, PhD^20*, Florent Carrette, Ph.D^20* and Pierluigi Porcu²¹

¹Department of Pathology, Saint-Louis Hospital, Paris, France
²Dermatopathology Section, Columbia University Irving Medical Center, New York
³Hematology Laboratory, Hopital Saint-Louis, AP-HP, Université Paris Cité, INSERM 1160, Paris, France
⁴Department of Dermatology, Hopital Saint-Louis, Université Paris Cité, Inserm U976, Paris, France
⁵Department of Dermatology, Multidisciplinary Cutaneous Lymphoma Program, Stanford University, Stanford
⁶Department of Dermatology, Columbia University Irving Medical Center, New York, NY
⁷Department of Dermatology, Hospital 12 de Octubre Medical School, Complutense University of Madrid, Madrid, Spain
⁸Department of Dermatology, University of Pennsylvania, Philadelphia
⁹Siteman Cancer Center, Washington University School of Medicine, Olivette, MO
¹⁰Department of Dermatology, CHU Montpellier, Université Montpellier I, Montpellier, France
¹¹AP-HP, Hôpital Henri-Mondor, Créteil, France
¹²Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
¹³Department of Dermatology, Centre Hospitalier Universitaire de Bordeaux – Inserm 1312, Bordeaux, France
¹⁴Department of Dermatology, Hospices Civils de Lyon, Pierre Bénite, France
¹⁵Dana Farber Cancer Institute, Boston, MA
¹⁶Dartmouth-Hitchcock Medical Center, Lebanon
¹⁷Department of Dermatology, Hopital Saint Louis, Université Paris Cité, Inserm U976, Paris, France
¹⁸Department of Dermatology, Multidisciplinary Cutaneous Lymphoma Program, Stanford University School of Medicine, Stanford
¹⁹Institute of Hematology "Seràgnoli", University of Bologna, Bologne, Italy
²⁰Innate Pharma, Marseille, France
²¹Department of Medical Oncology, Sidney Kimmel Comprehensive Cancer Center, Thomas Jefferson University, Philadelphia, PA

Yaping Zhang^1,2*, Zhengping Zhuang^1*, Herui Wang^1*, Juan Ye^1* and Wenyu Shi^3*

¹National Institutes of Health, Bethesda, MD
²Department of Hematology, Affiliated Hospital of Nantong University, Nantong, China
³Department of Oncology, Affiliated Hospital of Nantong University, Nantong, China

Alessandro La Ferlita, Ph.D^1*, Nicholas Staudinger, M.S^2,3*, Lara Bayraktar, B.S^2,3*, Katherine Chiappinelli, PhD^4*, Lapo Alinari, MD, Ph.D^5,6, Robert Baiocchi, MD, PhD⁵, Lalit Sehgal, PhD⁵ and Mamta Gupta, PhD^2,3,7

¹Division of Hematology, College of Medicine, The Ohio State University, Columbus, OH
²Department of Biochemistry and Molecular Medicine, George Washington University, Washington, DC
³George Washington Cancer Center, Washington, DC
⁴Microbiology and Immunology, George Washington University, Washington, DC
⁵James Comprehensive Cancer Center, The Ohio State University, Columbus, OH
⁶Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH
⁷Department of Biochemistry and Molecular Medicine, George Washington University, Rochester, MN

Danielle F Atibalentja, MD, PhD, Vishnupriya Kanakaveti, PhD^*, Lilian E Yao^* and Dean W Felsher, MD, PhD^*

Department of Medicine, Division of Oncology, Stanford University School of Medicine, Stanford, CA

Ruben Gimenez, MSc^1*, Neus Serrat, MD, PhD^2*, Miquel Castellote-Borrell, MSc^3,4*, Victor Jiménez-Martínez, MSc^5*, Eduardo Pérez del Río, PhD^6,7*, Mireia Bachiller^8*, Ferran Araujo-Ayala^9,10*, Raul F Pérez, PhD^5*, Ares Martínez-Farran, MSc^5*, Jose Ángel Robles, MSc^11*, Armando Lopez-Guillermo, MD^{10,12,13,14,15}, Elias Campo, MD, PhD¹⁶, Josep Villanueva^11,17*, Sonia Guedan^18*, Jose Ignacio Martin-Subero^19,20*, Judith Guasch^4,6,7*, Daniel J Hodson, MD-PhD^21,22, Dolors Colomer^17,20,23,24* and Patricia Pérez Galán, PhD^8,10*

¹Fundació de Recerca Clínic Barcelona - Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
²Fundació de Recerca Clínic Barcelona - Institut d’Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), Bacelona, ESP
³nstitute of Materials Science of Barcelona (ICMAB-CSIC), Bellaterra, Spain
⁴Dynamic Biomimetics for Cancer Immunotherapy, Max Planck Partner Group, ICMAB-CSIC, Bellaterra, Spain
⁵Fundació de Recerca Clínic Barcelona - Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain
⁶Institute of Materials Science of Barcelona (ICMAB-CSIC), Bellaterra, Spain
⁷Centro de Investigación Bimédica en Red de Bioingeniería, Biomateriales y Nanotecnologia (CIBERBBN), Madrid, Spain
⁸Fundació de Recerca Clínic Barcelona - Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, ESP
⁹Fundació de Recerca Clínic Barcelona - Institut d’Investigacions Biomèdiques August Pi I Sunyer (FRCB-IDIBAPS), Barcelona, ESP
¹⁰Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain
¹¹Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain
¹²Hospital Clínic de Barcelona, Barcelona, Spain
¹³University of Barcelona, Barcelona, Spain
¹⁴Department of Hematology, ICAMS, Hospital Clínic de Barcelona, Barcelona, Spain
¹⁵Instituto de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS), Barcelona, Spain
¹⁶Hospital Clinic Provincial, Barcelona, ESP
¹⁷Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Barcelona, Spain
¹⁸Fundació de Recerca Clínic Barcelona - Institut d’Investigacions Biomèdiques August Pi I Sunyer (FRCB-IDIBAPS), Barcelona, Spain
¹⁹Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain
²⁰Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
²¹Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
²²Wellcome-MRC Cambridge Stem Cell Institute and Department of Haematology, University of Cambridge, Cambridge, United Kingdom
²³Hematopathology Section, Pathology Department, Hospital Clínic de Barcelona, Barcelona, Spain
²⁴Universitat de Barcelona (UB), Barcelona, Spain

Charles Milrod, MD¹, Anna Dorota Chorzalska, PhD^1,2*, John Morgan, PhD^2*, Makayla R Pardo¹, Christina Raker, ScD^3*, Thomas Ollila, MD^1,4, Seo-Ho Lee^2*, Ari Pelcovits, MD¹, John L. Reagan, MD¹, Jessica McMahon, BSN^4*, Stephen Donnelly, BS^4*, Caylee Carmody, BS, MHS^4*, Jeannine Margolis, B.Sc.^5*, Matthew Matasar, MD, MS⁶, Scott F Huntington⁷, Patrycja M. Dubielecka, PhD^1,2 and Adam J. Olszewski, MD¹

¹Brown University, Providence, RI
²Dubielecka Lab, Rhode Island Hospital, Providence, RI
³Biostatistics, Epidemiology, and Research Design, Rhode Island Hospital, Providence, RI
⁴Lifespan Cancer Institute, Rhode Island Hospital, Providence, RI
⁵Brown University Oncology Research Group, Providence, RI
⁶Rutgers Cancer Institute of New Jersey, New Brunswick, NJ
⁷Yale School of Medicine, New Haven, CT

Fen Zhu, PhD^1*, Jing Wang, PhD^1*, Christine E. Ryan, MD¹, Liam Hackett^1*, Jeremy Zhang^1*, Stephen Jun Fei Chong, PhD¹ and Matthew S. Davids, MD, MMSc²

¹Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
²Department of Medical Oncology, Dana-Farber Cancer Institute, Inc., Boston, MA

Jose C. Villasboas Bisneto, MD¹, Danielle S Wallace, MD², Francesc Bosch, MD, PhD³, Carlos Grande Garcia, MD PhD^4*, Stephen D. Smith, MD⁵, Antonio Pinto^6*, Reid W. Merryman, MD⁷, Norma C. Gutierrez^8*, Jean Pierre Marolleau, MD⁹, Luca Arcaini^10*, Cristina García, MD^3*, Rocío Figueroa Mora, MD, PhD^4*, Brian G. Till, MD¹¹, Rosaria De Filippi, MD, PhD^6*, Sara Rattotti, MD^12*, Lucie Aubergeon, PhD^13*, Laurent Chêne, PhD^13*, Jan Fagerberg, MD, PhD¹³, Pier Luigi Zinzani, MD, PhD¹⁴, Philippe Armand, MD, PhD¹⁵, Jonathan W. Friedberg, MD¹⁶ and Stephen M. Ansell, MD, PhD¹

¹Mayo Clinic, Rochester, MN
²Wilmot Cancer Institute, University of Rochester, Rochester, NY
³University Hospital Vall d’Hebron, Barcelona, Spain
⁴Universidad de Navarra, Pamplona, Spain
⁵Fred Hutchinson Cancer Center, Seattle, WA
⁶Fondazione 'G. Pascale', IRCCS, Naples, Italy
⁷Dana-Farber Cancer Institute, Boston, MA
⁸Hospital Universitario De Salamanca, IBSAL, Salamanca, Spain
⁹Centre Hospitalier Universitaire Amiens-Picardie, Amiens, France
¹⁰Division of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
¹¹Fred Hutchinson Cancer Center, University of Washington, Seattle, WA
¹²Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy
¹³Enterome, Paris, France
¹⁴University of Bologna, Bologna, Italy
¹⁵Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
¹⁶University of Rochester, Rochester, NY

Yumi Nakayama, PhD^1*, Ajit Dhadve, PhD^2*, Wen Liu^1*, Lei Wu^1*, Neelam Kumari^2*, Amrutha Y^2*, Riddhita Deb^2*, Vijayaragavan Appanasamy^2*, Laura Armstrong^1*, Asier Antoranz, PhD^3*, Mark Kaplan, PhD^1*, Sambuddho Mukherjee, Ph.D.^4*, Anita K. Gandhi, PhD⁵ and Patrick R. Hagner, PhD^1*

¹Bristol Myers Squibb, Summit, NJ
²Biocon Bristol Myers Squibb Research & Development Center, Bangalore, India
³Intelligent Biodata Ltd, San Sebastian, Spain
⁴Bristol Myers Squibb, Bangalore, India
⁵Hematology, Translational Medicine, Bristol Myers Squibb, Summit, NJ

Xinyi Tang, MD, PhD^1*, Zhi-Zhang Yang, MD², Yue Yu^3*, Xiaosheng Wu, MD^4*, Vaishali Bhardwaj, PhD⁵, Prithviraj Mukherjee^1*, Patrizia Mondello, MD, PhD, MSc⁶, Hyojin Kim, PhD^7*, Anne J. Novak, PhD⁴ and Stephen M. Ansell, MD, PhD⁴

¹Division of Hematology, Mayo Clinic, ROCHESTER, MN
²Department of Hematology, Mayo Clinic, Rochester, MN
³Department of Quantitative Health Sciences, Mayo Clinic, ROCHESTER, MN
⁴Division of Hematology, Mayo Clinic, Rochester, MN
⁵Division of Hematology, Mayo Clinic, Rochester, ROCHESTER, MN
⁶Mayo Clinic, Rochester
⁷Division of Hematology, Mayo Clinic, Rochester

Janneke Eken, MSc^1*, Fleur R.M. Havenaar, BSc^1*, Edwin Quinten, BSc^1*, Ruben A.L. De Groen, MSc^1*, Julieta Sepulveda-Yanez, MSc^2*, Joost S.P. Vermaat³, Cornelis A.M. van Bergen^1* and Hendrik Veelken, MD, PhD ¹

¹Leiden University Medical Center, Leiden, Netherlands
²Facultad de Ciencias de la Salud, Universidad de Magallanes, Punta Arenas, Chile
³Department of Hematology, Leiden University Medical Center, Leiden, Netherlands

Alessandra Rossi^1*, Saveria Mazzara^2*, Maria Rosaria Sapienza, PhD^2*, Stefania Orecchioni^3*, Giovanna Talarico^3*, Paolo Falvo^3*, Alessandro Davini^4*, Claudio Ceccarelli^5*, Giovanna Motta^6*, Federica Melle, PhD^2*, Valentina Tabanelli^2*, Claudio Agostinelli, MD, PhD^6*, Davide Trere^5*, Marianna Penzo^5*, Chiara Corsini^3*, Elena Baiardi^4*, Angelica Calleri^2*, Umberto Vitolo, MD⁷, Francesco Bertolini, MD, PhD^3*, Pier Luigi Zinzani, MD⁸, Roberto Chiarle, MD^9,10, Corrado Tarella^11*, Stefano Pileri² and Enrico Derenzini, MD, PhD^12,13*

¹Onco-Hematology Division, European Institute of Oncology IRCCS, Milan, Italy
²Haematopathology Division, IEO European Institute of Oncology IRCCS, Milan, Italy
³European Institute of Oncology, Milano, Italy
⁴Onco-Hematology Division, IEO, European Institute of Oncology IRCCS, Milan, Italy
⁵University of Bologna, Bologna, Italy
⁶Haematopathology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
⁷Candiolo Cancer Institute, FPO-IRCCS, Candiolo (Turin), Italy
⁸Institute of Hematology “L. e A. Seràgnoli”, Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
⁹Children's Hospital Boston, Boston, MA
¹⁰Division of Hematopathology, European Institute of Oncology (IEO) IRCCS, Milan, Italy
¹¹Onco-Hematology Division, IEO European Institute of Oncology IRCCS, Milan, AL, Italy
¹²European Institute of Oncology, Milan, Italy
¹³Department of Health Sciences, University of Milan, Milan, Italy

Zhijuan Lin, MD^1*, Xingxing Yu^2*, Yan Hong^2*, Long Liu^2*, Zhifeng Li^2*, Jie Zha^2* and Bing Xu²

¹Department of Hematology, The First Affiliated Hospital of Xiamen University and Institute of Hematology, School of Medicine, Xiamen University, Xiamen, China
²Department of Hematology, The First Affiliated Hospital of Xiamen University and Institute of Hematology, School of Medicine, Xiamen University, Xiamen, Fujian, China

Juan Pablo Alderuccio, MD¹, Russ Kuker, MD^2*, Mark K Polar, MD^2*, Fei Yang, PhD^2* and Craig H. Moskowitz, MD³

¹Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL
²Department of Radiology, Division of Nuclear Medicine, University of Miami, Miller School of Medicine, Miami, FL
³Sylvester Comprehensive Cancer Center, Division of Hematology, University of Miami, Miller School of Medicine, Miami, FL

Tove Selvin^1*, Patrick Nylund, PhD^2*, Ann-Marie Ly, MD^2*, Anna Nikkarinen, MD^2*, Mattias Berglund, PhD^3*, Kossi D Abalo, PhD^2,4*, Daniel Molin^3*, Gunilla Enblad, MD, PhD^3*, Peter Hollander, MD, PhD^3*, Mats Hellström, MD, PhD^3* and Ingrid Glimelius, MD, PhD^2,4

¹Department of Immunology, Genetics and Pathology, Cancer Precision Medicine Unit, Uppsala University, Uppsala, AL, Sweden
²Department of Immunology, Genetics and Pathology, Cancer Precision Medicine Unit, Uppsala University, Uppsala, Sweden
³Department of Immunology, Genetics and Pathology, Cancer Immunotherapy Unit, Uppsala University, Uppsala, Sweden
⁴Department of Medicine, Clinical Epidemiology Division, Karolinska Institute, Stockholm, Sweden

Adi Zoref-Lorenz, MD¹, Elliot J Cahn^2*, Eric Mou, MD^3*, Yucai Wang, MD, PhD⁴, Matthew J. Maurer, DSc², Andrew L. Feldman, MD⁵, Bri J Negaard^2*, Raphael Mwangi, MS^2*, Gilad Itchaki^1*, Grzegorz S. Nowakowski, MD⁶, Thomas M. Habermann, MD⁴, Brian K. Link, MD^3*, Stephen M. Ansell, MD, PhD⁴, Anne J. Novak, PhD⁴, Gaurav Goyal, MD⁷, Thomas E. Witzig, MD⁸, James R. Cerhan, MD, PhD⁹ and Michael B. Jordan, MD¹⁰

¹Hematology Institute, Meir Medical Center, Kfar Saba, Israel
²Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN
³Division of Hematology, Oncology, and Blood & Marrow Transplantation, University of Iowa, Iowa City, IA
⁴Division of Hematology, Mayo Clinic, Rochester, MN
⁵Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
⁶Mayo Clinic, Rochester, MN
⁷Division of Hematology and Medical Oncology, University of Alabama at Birmingham, Birmingham, AL
⁸Division of Hematology, Mayo Clinic, Stabile 628, Rochester, MN
⁹Division of Epidemiology / Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN
¹⁰Divisions of Immunobiology, and Bone Marrow Transplantation and Immune Deficiency, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH

Yao Qi, MD^1*, Jia Wang^2*, Xin Li^3*, Juan Mu^4*, Rui Cui^5* and QI Deng^6*

¹Tianjin First Central Hospital, Tianjin, AL, China
²Department of Hematology, Tianjin First Central Hospital, Tianjin, CA, China
³Tianjin First Centre Hospital, Tianjin, AL, China
⁴Department of Hematology, Tianjin First Central Hospital, Tianjin, China
⁵Department of hematology, Tianjin First center hospital, Tianjin, China
⁶Tianjin First Central Hospital, Tianjin, China