Haley Newman, MD¹, Lahari Uppuluri, PhD^1*, Rawan Shraim, PhD^1*, Carl E Allen, MD², Kara L. Davis, DO^3*, Meenakshi Devidas, PhD, MBA⁴, Caroline Diorio, MD¹, Kimberly P. Dunsmore, MD^5*, Amira Elhachimi, BA^1*, David Frank, MD, PhD^6*, Lia Gore, MD⁷, Thomas Gross, MD^8*, Robert J. Hayashi^9*, Terzah M. Horton, MD, PhD^10*, Andrew Hughes, MD, PhD¹, Stephen P. Hunger, MD¹¹, John Kim^1*, Yimei Li, PhD^12*, Stephanie Si Lim, MD^13*, Mignon L. Loh, MD, PhD¹⁴, Charles G. Mullighan, MBBS, MSc, MD¹⁵, Adam B. Olshen, PhD^16*, Petri Pölönen, PhD^4*, Rachel E. Rau, MD^17*, Gongping Shi, PhD^18*, Kai Tan, PhD¹⁹, Tiffaney Vincent, BS^20*, Stuart S. Winter, MD²¹, Birte Wistinghausen, MD²², Brent L. Wood, MD, PhD²³, Jason Xu¹, Jun J. Yang, PhD²⁴, Rodney R. Miles, MD, PhD²⁵, Michelle L. Hermiston, MD, PhD²⁶ and David T. Teachey, MD¹

¹Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA
²Texas Children's Hospital, Houston, TX
³Stanford University, Stanford, CA
⁴St Jude Children's Research Hospital, Memphis, TN
⁵University of Virginia Health Sciences Center, Charlottesville, VA
⁶Division of Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA
⁷Center for Cancer and Blood Disorders, University of Colorado Cancer Center, Aurora, CO
⁸Phoenix Children's Hospital, Phoenix, AZ
⁹Department of Pediatrics, Division of Hematology / Oncology, Washington University School of Medicine, Saint Louis, MO
¹⁰Baylor College of Medicine/Dan L. Duncan Cancer Center and Texas Children's Canc, Houston, TX
¹¹Division of Oncology, Childrens Hospital of Philadelphia, Philadelphia
¹²Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
¹³Division of Oncology, John A. Burns School of Medicine, Honolulu, HI
¹⁴Ben Towne Center for Childhood Cancer Research, Seattle Children’s Hospital, Fred Hutch Cancer Center, University of Washington, Seattle, WA
¹⁵Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
¹⁶University of California, San Francisco, San Francisco, CA
¹⁷Texas Children's Hospital/Baylor College of Medicine, Houston, TX
¹⁸Division of Oncology, Children's Hospital of Philadelphia, Philadelphia
¹⁹Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA
²⁰The Children's Hospital of Philadelphia, Philadelphia, PA
²¹Cancer and Blood Disorders, Children's Minnesota, Eagan, MN
²²Children’s National Medical Center, Washington, DC
²³Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA
²⁴Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN
²⁵University of Utah, Salt Lake City, UT
²⁶Department of Pediatric, Division of Pediatric Hematology-Oncology, University of California San Francisco, Benioff Children’s Hospital, San Francisco, CA

Julia Costea^1,2,3*, Kerstin K. Rauwolf^4*, Pietro Zafferani^2,5*, Tobias Rausch^1,2,6*, Anna Mathioudaki^1,7*, Judith Zaugg^1,7*, Martin Schrappe, MD⁸, Cornelia Eckert, MD, PhD^9,10,11*, Gabriele Escherich, MD^12*, Jean-Pierre Bourquin, MD, PhD⁴, Beat Bornhauser^4*, Andreas E. Kulozik, MD, PhD^1,13,14,15 and Jan O. Korbel^1,16,17*

¹Molecular Medicine Partnership Unit, European Molecular Biology Laboratory (EMBL) and University Hospital Heidelberg, Heidelberg, Germany
²European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany
³Faculty of Biosciences, Heidelberg University, Heidelberg, Germany
⁴Department of Pediatric Oncology, University Children's Hospital Zurich, Zurich, Switzerland
⁵Molecular Biosciences/Cancer Biology Program, Heidelberg University and German Cancer Research Center (DKFZ), Heidelberg, Germany
⁶European Molecular Biology Laboratory (EMBL), Genomics Core Facility, Heidelberg, Germany
⁷European Molecular Biology Laboratory (EMBL), Structural and Computational Biology Unit, Heidelberg, Germany
⁸University Hospital Schleswig-Holstein, Department of Pediatrics, Campus Kiel, Kiel, Germany
⁹Charité Universitätsmedizin Berlin, Department of Hematology and Oncology, Berlin, Germany
¹⁰German Cancer Consortium (DKTK), Heidelberg, Germany
¹¹German Cancer Research Center (DKFZ), Heidelberg, Germany
¹²University Medical Center Hamburg-Eppendorf, Hamburg, Germany
¹³Hopp-Kindertumorzentrum Heidelberg (KiTZ), Heidelberg, Germany
¹⁴Clinical Cooperation Unit Pediatric Leukemia, German Cancer Research Center (DKFZ), Heidelberg, Germany
¹⁵Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University, Heidelberg, Germany
¹⁶Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
¹⁷Bridging Research Division on Mechanisms of Genomic Variation and Data Science, German Cancer Research Center (DKFZ), Heidelberg, Germany

Ashley Pinchinat, MD¹, John A. Kairalla, PhD², Meenakshi Devidas, PhD, MBA³, Andrew J. Carroll, PhD⁴, Mary Shago, PhD^5*, Anne Angiolillo, MD^6*, Michael J. Burke, MD^7*, Wanda L. Salzer, MD⁸, Naomi J. Winick, MD⁹, Mignon L. Loh, MD, PhD¹⁰, David T. Teachey, MD¹¹, Elizabeth A. Raetz, MD¹, Karen R Rabin, MD, PhD¹², Rachel E. Rau, MD¹⁰ and Sumit Gupta, MD, PhD¹³

¹Department of Pediatrics, NYU Langone Health, New York, NY
²University of Florida - Children's Oncology Group, Gainesville, FL
³St Jude Children's Research Hospital, Memphis, TN
⁴Department of Genetics, University of Alabama at Birmingham, Birmingham, AL
⁵The Hospital for Sick Children, Toronto, ON, CAN
⁶Servier Pharmaceuticals, Boston, MA
⁷Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI
⁸U.S. Army Medical Research and Materiel Command, Olney, MD
⁹Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX
¹⁰Ben Towne Center for Childhood Cancer Research, Seattle Children’s Hospital, Fred Hutch Cancer Center, University of Washington, Seattle, WA
¹¹Division of Oncology, Children's Hospital of Philadelphia, Rutledge, PA
¹²Department of Pediatrics, Baylor College of Medicine TX Children's Cancer Center, Houston, TX
¹³The Hospital For Sick Children, Toronto, ON, Canada

Rushabh Mehta, BA^1,2*, Changya Chen^2,3, Fatemeh Alikarami, PhD², Steven Foltz, PhD^4*, Avi Loren^5*, Elizabeth Li, MD^6*, Jason Xu^2,7, Marilyn M. Li, MD, MS^8*, Kathrin M. Bernt, MD⁹ and Kai Tan, PhD^7,10

¹Biomedical Graduate Studies, University of Pennsylvania, Philadelphia, PA
²Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA
³Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
⁴Division of Oncology, Children's Hospital of Philadelphia, Philadelphia
⁵University of Pennsylvania, Philadelphia, PA
⁶Children’s Hospital of Philadelphia, Philadelphia, PA
⁷Perelman School of Medicine, Philadelphia, PA
⁸Division of Genomic Diagnostics, Children’s Hospital of Philadelphia, Philadelphia
⁹Division Of Oncology/Center For Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, PA
¹⁰Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA

Tanxin Liu, MHS^1*, Jalen Langie, BS^1*, Wenjian Yang, PhD^2*, Libby Morimoto, PhD^3*, Xiaomei Ma, PhD^4*, Catherine Metayer, MD, PhD^3*, Philip J Lupo, PhD^5,6*, Michael E. Scheurer, PhD^5,7, Jun J. Yang, PhD², Joseph L. Wiemels, PhD^8*, Charleston W.K. Chiang, PhD^1* and Adam J. de Smith, PhD⁸

¹Center for Genetic Epidemiology, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA
²Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN
³Division of Epidemiology, School of Public Health, University of California, Berkeley, Berkeley, CA
⁴Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT
⁵Department of Pediatrics, Baylor College of Medicine, Houston, TX
⁶Cancer and Hematology Center, Texas Children's Hospital, Houston, TX
⁷Texas Children's Hospital, Houston, TX
⁸Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA

Alina M. Hartmann^1,2*, Lorenz Bastian^1,2,3*, Malwine J Barz, PhD^1,2,3*, Eric Amelunxen, MD^3*, Johannes Haas^4*, Lennart Lenk, PhD^1,2,5*, Michaela Kotrova, MD, PhD^2,3*, Thomas Beder^2,3*, Fabio D. Steffen, PhD^4*, Kerstin K. Rauwolf^4*, Nadine Wolgast^1,2,3*, Patrick Ehm^1,2,6*, Sonja Bendig^1,2,3*, Julia Alten^6*, Mayukh Mondal^1,7*, Aeint-Steffen Ströh, MD^2,3*, Thomas Burmeister, MD, PhD^8*, Nicola Goekbuget, MD⁹, Beat Bornhauser^4*, Jean-Pierre Bourquin, MD, PhD⁴, Monika Brüggemann, MD^1,2,10*, Martin Schrappe, MD^1,11, Gunnar Cario, MD^1,2,12* and Claudia D Baldus, MD^1,2,10*

¹Clinical Research Unit CATCH ALL (KFO 5010/1) funded by the Deutsche Forschungsgemeinschaft, Kiel, Germany
²University Medical Center Schleswig-Holstein, University Cancer Center Schleswig-Holstein, Kiel, Germany
³Department of Internal Medicine II (Hematology/Oncology), University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany
⁴Department of Pediatric Oncology, University Children's Hospital Zurich, Zurich, Switzerland
⁵Department of Pediatrics I, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany
⁶Department of Pediatrics I, University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany
⁷Christian Albrechts University Kiel, Institute for Clinical Molecular Biology, Kiel, Germany
⁸Department of Hematology, Oncology and Cancer Immunology (Campus Virchow Klinikum), Charité – Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin, Berlin, Germany
⁹Department of Medicine, Hematology/Oncology, Goethe University Frankfurt, University Hospital, Frankfurt, Germany
¹⁰Department of Internal Medicine II (Hematology/Oncology), University Hospital Schleswig-Holstein, Kiel, Germany
¹¹Pediatric Haematology/Oncology, ALL-BFM Study Group, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany
¹²Department of Pediatrics I, University Hospital Schleswig-Holstein, Kiel, Germany