-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

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614.O2.6 614. Acute Lymphoblastic Leukemias: Biomarkers, Molecular Markers, and Minimal Residual Disease in Diagnosis and Prognosis: Genomic Determinants of Outcomes In ALL

Symposia: Acute Lymphoblastic Leukemias: Biomarkers, Molecular Markers, and Minimal Residual Disease in Diagnosis and Prognosis Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Research, Clinical trials, Lymphoid Leukemias, ALL, Artificial intelligence (AI), Fundamental Science, Translational Research, Lymphomas, Genomics, Clinical Research, Bioinformatics, Health disparities research, Diversity, Equity, and Inclusion (DEI), Pediatric, T Cell lymphoma, Diseases, Lymphoid Malignancies, Young adult , Computational biology, Biological Processes, Molecular biology, Technology and Procedures, Study Population, Human, Measurable Residual Disease , Machine learning, Omics technologies
Saturday, December 7, 2024: 4:00 PM-5:30 PM
Marriott Grand Ballroom 8-9 (Marriott Marquis San Diego Marina)
Moderators:
Caner Saygin, MD, University of Chicago and Silvia Bresolin, PhD,
Disclosures:
No relevant conflicts of interest to declare.
4:00 PM

Haley Newman, MD1, Lahari Uppuluri, PhD1*, Rawan Shraim, PhD1*, Carl E Allen, MD2, Kara L. Davis, DO3*, Meenakshi Devidas, PhD, MBA4, Caroline Diorio, MD1, Kimberly P. Dunsmore, MD5*, Amira Elhachimi, BA1*, David Frank, MD, PhD6*, Lia Gore, MD7, Thomas Gross, MD8*, Robert J. Hayashi9*, Terzah M. Horton, MD, PhD10*, Andrew Hughes, MD, PhD1, Stephen P. Hunger, MD11, John Kim1*, Yimei Li, PhD12*, Stephanie Si Lim, MD13*, Mignon L. Loh, MD, PhD14, Charles G. Mullighan, MBBS, MSc, MD15, Adam B. Olshen, PhD16*, Petri Pölönen, PhD4*, Rachel E. Rau, MD17*, Gongping Shi, PhD18*, Kai Tan, PhD19, Tiffaney Vincent, BS20*, Stuart S. Winter, MD21, Birte Wistinghausen, MD22, Brent L. Wood, MD, PhD23, Jason Xu1, Jun J. Yang, PhD24, Rodney R. Miles, MD, PhD25, Michelle L. Hermiston, MD, PhD26 and David T. Teachey, MD1

1Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA
2Texas Children's Hospital, Houston, TX
3Stanford University, Stanford, CA
4St Jude Children's Research Hospital, Memphis, TN
5University of Virginia Health Sciences Center, Charlottesville, VA
6Division of Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA
7Center for Cancer and Blood Disorders, University of Colorado Cancer Center, Aurora, CO
8Phoenix Children's Hospital, Phoenix, AZ
9Department of Pediatrics, Division of Hematology / Oncology, Washington University School of Medicine, Saint Louis, MO
10Baylor College of Medicine/Dan L. Duncan Cancer Center and Texas Children's Canc, Houston, TX
11Division of Oncology, Childrens Hospital of Philadelphia, Philadelphia
12Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
13Division of Oncology, John A. Burns School of Medicine, Honolulu, HI
14Ben Towne Center for Childhood Cancer Research, Seattle Children’s Hospital, Fred Hutch Cancer Center, University of Washington, Seattle, WA
15Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
16University of California, San Francisco, San Francisco, CA
17Texas Children's Hospital/Baylor College of Medicine, Houston, TX
18Division of Oncology, Children's Hospital of Philadelphia, Philadelphia
19Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA
20The Children's Hospital of Philadelphia, Philadelphia, PA
21Cancer and Blood Disorders, Children's Minnesota, Eagan, MN
22Children’s National Medical Center, Washington, DC
23Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA
24Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN
25University of Utah, Salt Lake City, UT
26Department of Pediatric, Division of Pediatric Hematology-Oncology, University of California San Francisco, Benioff Children’s Hospital, San Francisco, CA

4:15 PM

Julia Costea1,2,3*, Kerstin K. Rauwolf4*, Pietro Zafferani2,5*, Tobias Rausch1,2,6*, Anna Mathioudaki1,7*, Judith Zaugg1,7*, Martin Schrappe, MD8, Cornelia Eckert, MD, PhD9,10,11*, Gabriele Escherich, MD12*, Jean-Pierre Bourquin, MD, PhD4, Beat Bornhauser4*, Andreas E. Kulozik, MD, PhD1,13,14,15 and Jan O. Korbel1,16,17*

1Molecular Medicine Partnership Unit, European Molecular Biology Laboratory (EMBL) and University Hospital Heidelberg, Heidelberg, Germany
2European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany
3Faculty of Biosciences, Heidelberg University, Heidelberg, Germany
4Department of Pediatric Oncology, University Children's Hospital Zurich, Zurich, Switzerland
5Molecular Biosciences/Cancer Biology Program, Heidelberg University and German Cancer Research Center (DKFZ), Heidelberg, Germany
6European Molecular Biology Laboratory (EMBL), Genomics Core Facility, Heidelberg, Germany
7European Molecular Biology Laboratory (EMBL), Structural and Computational Biology Unit, Heidelberg, Germany
8University Hospital Schleswig-Holstein, Department of Pediatrics, Campus Kiel, Kiel, Germany
9Charité Universitätsmedizin Berlin, Department of Hematology and Oncology, Berlin, Germany
10German Cancer Consortium (DKTK), Heidelberg, Germany
11German Cancer Research Center (DKFZ), Heidelberg, Germany
12University Medical Center Hamburg-Eppendorf, Hamburg, Germany
13Hopp-Kindertumorzentrum Heidelberg (KiTZ), Heidelberg, Germany
14Clinical Cooperation Unit Pediatric Leukemia, German Cancer Research Center (DKFZ), Heidelberg, Germany
15Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University, Heidelberg, Germany
16Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
17Bridging Research Division on Mechanisms of Genomic Variation and Data Science, German Cancer Research Center (DKFZ), Heidelberg, Germany

4:30 PM

Ashley Pinchinat, MD1, John A. Kairalla, PhD2, Meenakshi Devidas, PhD, MBA3, Andrew J. Carroll, PhD4, Mary Shago, PhD5*, Anne Angiolillo, MD6*, Michael J. Burke, MD7*, Wanda L. Salzer, MD8, Naomi J. Winick, MD9, Mignon L. Loh, MD, PhD10, David T. Teachey, MD11, Elizabeth A. Raetz, MD1, Karen R Rabin, MD, PhD12, Rachel E. Rau, MD10 and Sumit Gupta, MD, PhD13

1Department of Pediatrics, NYU Langone Health, New York, NY
2University of Florida - Children's Oncology Group, Gainesville, FL
3St Jude Children's Research Hospital, Memphis, TN
4Department of Genetics, University of Alabama at Birmingham, Birmingham, AL
5The Hospital for Sick Children, Toronto, ON, CAN
6Servier Pharmaceuticals, Boston, MA
7Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI
8U.S. Army Medical Research and Materiel Command, Olney, MD
9Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX
10Ben Towne Center for Childhood Cancer Research, Seattle Children’s Hospital, Fred Hutch Cancer Center, University of Washington, Seattle, WA
11Division of Oncology, Children's Hospital of Philadelphia, Rutledge, PA
12Department of Pediatrics, Baylor College of Medicine TX Children's Cancer Center, Houston, TX
13The Hospital For Sick Children, Toronto, ON, Canada

4:45 PM

Rushabh Mehta, BA1,2*, Changya Chen2,3, Fatemeh Alikarami, PhD2, Steven Foltz, PhD4*, Avi Loren5*, Elizabeth Li, MD6*, Jason Xu2,7, Marilyn M. Li, MD, MS8*, Kathrin M. Bernt, MD9 and Kai Tan, PhD7,10

1Biomedical Graduate Studies, University of Pennsylvania, Philadelphia, PA
2Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA
3Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
4Division of Oncology, Children's Hospital of Philadelphia, Philadelphia
5University of Pennsylvania, Philadelphia, PA
6Children’s Hospital of Philadelphia, Philadelphia, PA
7Perelman School of Medicine, Philadelphia, PA
8Division of Genomic Diagnostics, Children’s Hospital of Philadelphia, Philadelphia
9Division Of Oncology/Center For Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, PA
10Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA

5:00 PM

Tanxin Liu1*, Jalen Langie, BS1*, Wenjian Yang, PhD2*, Libby Morimoto, PhD3*, Xiaomei Ma, PhD4*, Catherine Metayer, MD, PhD3*, Philip J Lupo, PhD5,6*, Michael E. Scheurer, PhD5,7, Jun J. Yang, PhD2, Joseph L. Wiemels, PhD8*, Charleston W.K. Chiang, PhD1* and Adam J. de Smith, PhD8

1Center for Genetic Epidemiology, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA
2Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN
3Division of Epidemiology, School of Public Health, University of California, Berkeley, Berkeley, CA
4Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT
5Department of Pediatrics, Baylor College of Medicine, Houston, TX
6Cancer and Hematology Center, Texas Children's Hospital, Houston, TX
7Texas Children's Hospital, Houston, TX
8Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA

5:15 PM

Alina M. Hartmann1,2*, Lorenz Bastian1,2,3*, Malwine J Barz, PhD1,2,3*, Eric Amelunxen, MD3*, Johannes Haas4*, Lennart Lenk, PhD1,2,5*, Michaela Kotrova, MD, PhD2,3*, Thomas Beder2,3*, Fabio D. Steffen, PhD4*, Kerstin K. Rauwolf4*, Nadine Wolgast1,2,3*, Patrick Ehm1,2,6*, Sonja Bendig1,2,3*, Julia Alten6*, Mayukh Mondal1,7*, Aeint-Steffen Ströh, MD2,3*, Thomas Burmeister, MD, PhD8*, Nicola Goekbuget, MD9, Beat Bornhauser4*, Jean-Pierre Bourquin, MD, PhD4, Monika Brüggemann, MD1,2,10*, Martin Schrappe, MD1,11, Gunnar Cario, MD1,2,12* and Claudia D Baldus, MD1,2,10*

1Clinical Research Unit CATCH ALL (KFO 5010/1) funded by the Deutsche Forschungsgemeinschaft, Kiel, Germany
2University Medical Center Schleswig-Holstein, University Cancer Center Schleswig-Holstein, Kiel, Germany
3Department of Internal Medicine II (Hematology/Oncology), University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany
4Department of Pediatric Oncology, University Children's Hospital Zurich, Zurich, Switzerland
5Department of Pediatrics I, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany
6Department of Pediatrics I, University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany
7Christian Albrechts University Kiel, Institute for Clinical Molecular Biology, Kiel, Germany
8Department of Hematology, Oncology and Cancer Immunology (Campus Virchow Klinikum), Charité – Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin, Berlin, Germany
9Department of Medicine, Hematology/Oncology, Goethe University Frankfurt, University Hospital, Frankfurt, Germany
10Department of Internal Medicine II (Hematology/Oncology), University Hospital Schleswig-Holstein, Kiel, Germany
11Pediatric Haematology/Oncology, ALL-BFM Study Group, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany
12Department of Pediatrics I, University Hospital Schleswig-Holstein, Kiel, Germany

*signifies non-member of ASH