Melissa A. Burns, MD¹, Yael Flamand, MS^2*, Lynda M. Vrooman, MD¹, Victoria B. Koch, BS^1*, Yves Theoret, PhD^3*, Sarah M. Cronholm^1*, Sarah K. Hunt, BS, MPH^1*, Peter D. Cole, MD⁴, Lisa M. Gennarini, MD^5*, Nobuko Hijiya, MD⁶, Justine M. Kahn, MD, MSc⁷, Kara M. Kelly, MD⁸, Bruno Michon, MD, FRCPC^9*, Donna S. Neuberg, Sc.D^2*, Andrew E. Place, MD, PhD¹, Thai Hoa Tran, MD^10*, Jennifer J.G. Welch, MD¹¹, Stephen E. Sallan, MD¹ and Lewis B. Silverman, MD⁷

¹Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA
²Department of Data Science, Dana-Farber Cancer Institute, Boston, MA
³Department of Pharmacology and Physiology, Hospital Sainte-Justine, University of Montreal, Montréal, QC, Canada
⁴Division of Pediatric Hematology/Oncology, Rutgers Cancer Institute, New Brunswick, NJ
⁵Division of Pediatric Hematology/Oncology and Blood & Marrow Cell Transplant, Montefiore Medical Center, Bronx, NY
⁶Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Columbia University Medical Center, New York, NY
⁷Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Columbia University Irving Medical Center, New York, NY
⁸Department of Pediatric Oncology, Roswell Park Comprehensive Cancer Center, University at Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY
⁹Division of Hematology-Oncology, Centre Hospitalier Universitaire De Québec, Québec City, QC, Canada
¹⁰Division of Pediatric Hematology and Oncology, CHU Sainte-Justine, University of Montreal, Montreal, QC, CAN
¹¹Division of Pediatric Hematology and Oncology, Hasbro Children’s Hospital, Warren Alpert Medical School of Brown University, Providence, RI

Daniel J. DeAngelo, MD, PhD¹, Jun Yin^2*, Anjali S. Advani, MD³, Selina Luger, MD, FRCPC⁴, Jill Fulcher, MD, PhD, FRCPath⁵, Michaela Liedtke, MD⁶, Geoffrey L. Uy, MD⁷, Shira N. Dinner, MD⁸, Lindsay Wilde, MD⁹, Marlise R. Luskin, MD¹, Caner Saygin, MD¹⁰, Ella Postich^10*, Noreen Fulton^10*, Richard C. Harvey, PhD^11*, Gaby E Perez Burbano, MS^12*, Rebecca Teske^12*, Harry P. Erba, MD, PhD¹³, Mark R. Litzow, MD¹⁴, Richard M. Stone, MD¹ and Wendy Stock, MD¹⁰

¹Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
²Department of Biostatistics and Bioinformatics, HL Moffitt Cancer Center, Tampa, FL
³Department of Hematology and Medical Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH
⁴Abramson Cancer Center, Hospital of the University of Pennsylvania, Philadelphia, PA
⁵Department of Medicine, University of Ottawa at The Ottawa Hospital and the Ottawa Hospital Research Institute, Ottawa, ON, CAN
⁶Stanford University Cancer Center, Stanford, CA
⁷Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO
⁸Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL
⁹Sidney Kimmel Comprehensive Cancer Center, Thomas Jefferson University, Philadelphia, PA
¹⁰Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL
¹¹University of New Mexico School of Medicine, Albuquerque, NM
¹²Division of Clinical Trials and Biostatistics, Mayo Clinic, Rochester, MN
¹³Duke University Cancer Institute, Durham, NC
¹⁴Division of Hematology, Mayo Clinic, Rochester, MN

Martin Schrappe, MD^1,2, Hanna Marie Gottschalk, MD^3*, Valentino Conter, MD^4*, Gunnar Cario, MD^1,5*, Jan Stary, MD, DSc^6,7*, Anja Möricke, MD^5*, Michael Dworzak, MD^8,9*, Andishe Attarbaschi, MD^10,11*, Draga Barbaric, MD^12,13*, Franco Locatelli, MD^14,15, Nicole Bodmer, MD^16*, Sarah Elitzur, MD^17,18, Daniela Silvestri^4*, Luciano Dalla-Pozza, MD¹⁹, Bernd Gruhn^20,21*, Shai Izraeli, MD^17,22, Carmelo Rizzari, MD, PhD^23*, Jean-Pierre Bourquin, MD, PhD²⁴, Andrea Biondi²⁵, Maria Grazia Valsecchi, PhD^25* and Martin Zimmermann, PhD^26*

¹Clinical Research Unit CATCH ALL (KFO 5010/1) funded by the Deutsche Forschungsgemeinschaft, Kiel, Germany
²Pediatric Hematology/Oncology, ALL-BFM Study Group, Christian-Albrechts-University, Medical Faculty, Kiel, Kiel, Germany
³Pediatrics, ALL-BFM Study Group, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany
⁴Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy
⁵Department of Pediatrics I, Pediatric Hematology and Oncology, ALL-BFM Study Group, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany
⁶Charles University and University Hospital Motol, CLIP - Childhood Leukaemia Investigation Prague, Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Prague, Czech Republic
⁷Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic
⁸St. Anna Children's Cancer Research Institute, Vienna, Austria
⁹Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, St. Anna Children's Hospital, Vienna, Austria
¹⁰Department of Pediatric Hematology and Oncology, St. Anna Kinderspital, Vienna, Austria
¹¹St. Anna Children´s Cancer Research Institute (CCRI), Vienna, Austria
¹²Kids Cancer Centre, Sydney Children's Hospital, School of Clinical Medicine, UNSW Sydney, Sydney, Sydney, Australia
¹³Centre for Children's Cancer and Blood Disorders, Sydney Children's Hospital, Randwick NSW, AUS
¹⁴IRCCS Ospedale Pediatrico Bambino Gesù, Catholic University of the Sacred Heart, Rome, Italy
¹⁵Department of Pediatric Hematology/Oncology, Cell and Gene Therapy, IRCCS Bambino Gesù Children’s Hospital, Catholic University of the Sacred Heart, Rome, Italy
¹⁶Department of Oncology, University Children's Hospital Zurich, Zurich, Switzerland
¹⁷Department of Pediatric Hematology and Oncology, Schneider Children's Medical Center and Tel Aviv University, Petah Tikva, Israel
¹⁸Schneider Children's Medical Center, Petah Tikva, Israel
¹⁹Cancer Centre for Children, Sydney, Australia
²⁰Department of Pediatrics, Jena University Hospital, Jena, Germany
²¹Department of Pediatrics, Department of Pediatrics, Jena, Germany
²²Pediatric Hematology-Oncology, Sheba Medical Center, Petach Tikva, Israel
²³Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy
²⁴Department of Pediatric Oncology, University Children's Hospital Zurich, Zurich, Switzerland
²⁵School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy
²⁶Department of Pediatric Hematology and Oncology, Medical School Hannover, Hannover, Germany

Erica Brivio, MD, PhD^1*, Edoardo Pennesi, PhD^1*, Yilin Jang^1*, Anneke Ammerlaan^1*, Susana Rives^2*, Inge M. van der Sluis, MD, PhD¹, Caroline Lindemans, MD, PhD³, Bella Bielorai, MD^4*, Cristina Díaz De Heredia^5*, Andrej Lissat, MD, PhD^6*, Claudia Rossig, MD, PhD⁷, Arnaud Petit, MD, PhD^8*, Fanny Rialland Battisti, MD^9*, Carmelo Rizzari, MD, PhD^10,11*, Anna B Nilsson, MD, PhD^12*, Benedicte Bruno^13*, Alba Rubio-san-Simón, MD^14*, Lucie Sramkova, MD, PhD^15*, Gernot Engstler, MD^16*, Uta Dirksen, MD, PhD^17*, Benoit Brethon, MD^18*, Barbara De Moerloose, MD^19*, Marlène Pasquet, MD^20*, Peter McCarthy, MD^21*, Karsten Nysom, MD, PhD^22*, Carine Halfon-Domenech, MD^23*, Nicoletta Bertorello, MD^24*, Jochen Büchner, MD, PhD^25*, Franco Locatelli, MD²⁶ and C. Michel Zwaan, Prof. Dr.^1,27*

¹Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
²Department of Pediatric Hematology and Oncology, Hospital Sant Joan de Déu, Barcelona, Spain
³Dept. of Stem Cell Transplantation, Princess Máxima Center For Pediatric Oncology, Utrecht, Netherlands
⁴Sheba Medical Center, Ramat-Gan, Israel
⁵Pediatric Oncology and Hematology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain
⁶Department of Hematology and Oncology, Charité Universitätsmedizin Berlin, Berlin, Germany
⁷Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany
⁸Hôpital Armand Trousseau, APHP, PARIS, Île-de-France, France
⁹Hématologie et oncologie pédiatrique, CHU Hôtel Dieu, Nantes, FRA
¹⁰Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy
¹¹School of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy
¹²Karolinska Institutet, Solna, Sweden
¹³Chru Lille, Jeanne De Flandre Hématologie Pédiatrique, Lille, FRA
¹⁴Department of Pediatric Oncology and Hematology, Hospital Niño Jesús, Madrid, ESP
¹⁵Department of Pediatric Hematology and Oncology, Second Faculty of Medicine, Charles University/University Hospital Motol, Prague, Czech Republic
¹⁶St Anna Children's Hospital, Medical University of Vienna,, Vienna,, Austria
¹⁷University Childrens Hospital Essen, Essen, DEU
¹⁸Pediatric Hematology and Immunology Department, Robert Debré Academic Hospital, GHU AP-HP Nord Université Paris Cité, Paris, FRA
¹⁹Department of Pediatric Hematology-Oncology, Ghent University Hospital, Ghent, Belgium
²⁰Department of Pediatric Hematology and Oncology, Centre Hospitalo-Universitaire de Toulouse, Toulouse, France
²¹Children’s Health Ireland at Crumlin, Dublin, Ireland
²²Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital–Rigshospitalet, Copenhagen, Hovedstaden, DNK
²³Institut D'Hématologie Et D'Oncologie Pédiatrique, Lyon, France
²⁴Pediatric Oncohematology, University of Turin-Regina Margherita Children Hospital, Turin, Italy
²⁵Oslo University Hospital, Oslo, Norway
²⁶Department of Pediatric Hematology/Oncology, Cell and Gene Therapy, IRCCS Bambino Gesù Children’s Hospital, Catholic University of the Sacred Heart, Rome, Italy
²⁷Department of Pediatric Oncology, Erasmus MC/Sophia Children's Hospital, Rotterdam, Netherlands

Lynda M. Vrooman, MD¹, Yael Flamand, MS^2*, Melissa A. Burns, MD¹, Victoria B. Koch, BS^1*, Sarah M. Cronholm^1*, Sarah K. Hunt, BS, MPH^1*, Peter D. Cole, MD³, Lisa M. Gennarini, MD^4*, Marian H. Harris, MD, PhD^5*, Nobuko Hijiya, MD⁶, Justine M. Kahn, MD, MSc⁷, Kara M. Kelly, MD⁸, Bruno Michon, MD, FRCPC^9*, Andrew E. Place, MD, PhD¹, Thai Hoa Tran, MD^10*, Jennifer J.G. Welch, MD¹¹, Stephen E. Sallan, MD¹ and Lewis B. Silverman, MD⁷

¹Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA
²Department of Data Science, Dana-Farber Cancer Institute, Boston, MA
³Division of Pediatric Hematology/Oncology, Rutgers Cancer Institute, New Brunswick, NJ
⁴Division of Pediatric Hematology/Oncology and Blood & Marrow Cell Transplant, Montefiore Medical Center, Bronx, NY
⁵Department of Pathology, Boston Children's Hospital, Boston, MA
⁶Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Columbia University Medical Center, New York, NY
⁷Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Columbia University Irving Medical Center, New York, NY
⁸Department of Pediatric Oncology, Roswell Park Comprehensive Cancer Center, University at Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY
⁹Division of Hematology-Oncology, Centre Hospitalier Universitaire De Québec, Québec City, QC, Canada
¹⁰Division of Pediatric Hematology and Oncology, CHU Sainte-Justine, University of Montreal, Montreal, QC, CAN
¹¹Division of Pediatric Hematology and Oncology, Hasbro Children’s Hospital, Warren Alpert Medical School of Brown University, Providence, RI

Peijing Qi^1*, Yuanyuan Zhang^1*, Ying Wu^1*, Jiaole Yu^1*, Jia Fan^1*, Wei Lin^1*, Huyong Zheng² and Ruidong Zhang^1*

¹Hematology Center, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China
²Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Hematology Center, Beijing, China