Nazia Matto, PhD^1*, Shreyans Gandhi, MD, MBBS, DNB, FRCPath, MPhil, MRCP^1,2*, Marta Rzepkowska^1*, Sila Gerlevik^1*, Mohammad M Karimi^3*, Austin G. Kulasekararaj, MD, MBBS, FRCPath, MRCP^1,4, Abdel Douiri, PhD^5*, Angela Miller^6*, Lynne Duran^2*, Haili Cui^2*, Jen Lewis^2*, Shahram Kordasti, MD, PhD⁷, Giovanna Lombardi, PhD^8*, Giorgio Napolitani, PhD^1* and Ghulam Jeelani Mufti, MB, DM, FRCP, FRCPath^1,2*

¹Department of Hemato-oncology, Kings College London, London, United Kingdom
²Kings College Hospital, NHS Foundation Trust, London, United Kingdom
³Comprehensive Cancer Centre, Kings College London, London, United Kingdom
⁴King's College Hospital NHS Foundation Trust, London, United Kingdom
⁵Division of Population Health Sciences, King's College London, London, United Kingdom
⁶LifeArc, London, United Kingdom
⁷Kings College London, London, United Kingdom
⁸MRC Centre for Transplantation, King's College London, London, United Kingdom

Antonio M Risitano, MD, PhD^1,2, Simona Iacobelli^3*, Austin G. Kulasekararaj, MD, MBBS, FRCPath, MRCP⁴, Marleen Van Os^5*, Sophie Terwel^6*, Morag Griffin, MBChB, MRCP^7*, Constantijn J.M. Halkes, MD^8*, Christian Recher, MD, PhD^9*, Fiorenza Barraco^10*, Edouard Forcade, MD, PhD^11*, Carlos Vallejo^12*, Beatrice Drexler, MD^13*, Jean-Baptiste Méar, MD^14*, Alexander Smith^15*, Emanuele Angelucci, MD¹⁶, Reinier Raymakers, MD¹⁷, Marco R De Groot^18*, Etienne Daguindau, MD^19*, Erfan Nur^20*, Wilma Barcellini, MD^21*, Nigel H. Russell, MD²², Louis Terriou, MD PhD^23*, Anna Paola Iori^24*, Walter Barberi^25*, Anna Sureda Balari, MD, PhD²⁶, Isabel Sanchez-Ortega^27*, Blanca Xicoy, MD^28*, Isidro Jarque Ramos^29*, Jamie Cavenagh^30*, Flore Sicre De Fontbrune^31,32*, Camilla Frieri^33*, Talha Munir, MBBS, PhD³⁴, Jennifer Tjon^35*, Suzanne Tavitian, MD^36*, Aline Praire^37*, Laurence Clement^38*, Florence Rabian, MD^39*, Luana Marano, MD^2*, Anita Hill^40,41*, Elena Palmisani^42*, Petra Muus, MD⁴³, Serena Marotta^44*, Fabiana Cacace^45*, Marica Laurino, MD^46*, Jakob Passweg Sr.⁴⁷, Judith Marsh, MD^48*, Gerard Socie^49,50, Ghulam Mufti^51*, Carlo Dufour, MD^1,52 and Regis Peffault De Latour^31,53,54*

¹Severe Aplastic Anemia Working Party, European Group for Blood and Marrow Transplantation (EBMT), Leiden, Netherlands
²Hematology and BMT Unit, AORN San Giuseppe Moscati, Avellino, Italy
³Centro Di Biostatistica E Bioinformatica Università Tor Vergata, Rome, ITA
⁴King’s College Hospital-NHS Foundation Trust, NIHR/Wellcome King’s Clinical Research Facility, and King’s College London, London, United Kingdom
⁵EBMT Data Office, Leiden, NLD
⁶EBMT Data Office, Leiden, Netherlands
⁷Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
⁸Hematology, Leiden University Medical Center, Leiden, Netherlands
⁹ICUT oncopole, Toulouse, FRA
¹⁰Service d’Hematologie Clinique, Hôpital universitaire, Lyon, France
¹¹Service d'Hématologie Clinique et Thérapie Cellulaire, CHU Bordeaux, Bordeaux, France
¹²Hospital Clínico Universitario de Santiago, Oviedo, Spain
¹³Department of Hematology, University Hospital Basel, Basel, Switzerland
¹⁴Hematology Clinic, Rennes University Hospital, Rennes, France
¹⁵King's College London Rayne Institute, London, GBR
¹⁶Hematology and Cellular Therapy, IRCCS Ospedale Policlinico San Martino, Genova, ITA
¹⁷University Medical Centre, Utrecht, Netherlands
¹⁸University Medical Center Groningen, Groningen, Netherlands
¹⁹Department of Clinical Hematology, Hopital Jean Minjoz, Service d'Onco-hématologie, Besançon, France
²⁰Department of Hematology, Amsterdam University Medical Centers, Amsterdam, Netherlands
²¹Hematology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
²²Nottingham University Hospital (City Hospital Campus), Nottingham, ENG, United Kingdom
²³Lille University Hospital, Lille, FRA
²⁴Department of Translational and Precision Medicine, Policlinico Umberto I Hospital, Sapienza University of Rome, Roma, Roma, ITA
²⁵Policlinico Umberto I Hospital, Sapienza University of Rome, Department of Translational and Precision Medicine, ITA, Rome, Italy
²⁶Hematology Department, Institut Catala d'Oncologia, Hospital Duran i Reynals, L'Hospitalet De Llobregat, Spain
²⁷Institut Catalá d'Oncologia – Hospital Duran i Reynals, Barcelona, Spain
²⁸Hematology Service, ICO-Hospital Germans Trias i Pujol, Institut de Recerca contra la Leucèmia Josep Carreras (IJC), Universitat Autònoma de Barcelona, Badalona, Spain
²⁹University Hospital La Fe, Valencia, Spain
³⁰St. Bartholomew's Hospital London, London, United Kingdom
³¹Hematology and Transplant Unit, Saint Louis Hospital, APHP, Paris, France
³²French Reference Center for Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria, Saint Louis Hospital, Paris, France
³³Hematology and Transplant Unit, A.O.R.N. S. Giuseppe Moscati, Avellino, Italy
³⁴Department of Haematology, St. James's University Hospital, Leeds, United Kingdom
³⁵Leiden University Medical Center, Leiden, NLD
³⁶Department of Hematology, Toulouse University Cancer Institute Oncopole, Toulouse University Hospital, Toulouse, France
³⁷Centre Hospitalier Lyon Sud, Lyon, France
³⁸CHU Bordeaux, Hopital Haut-Leveque, Pessac, France
³⁹Hematology Adolescents and Young Adult Unit, Saint-Louis Hospital, APHP, Paris, France, Paris, France
⁴⁰Alexion Pharmaceuticals Inc, London, GBR
⁴¹St James University Hospital Leeds, Leeds, United Kingdom
⁴²Gaslini Children Hospital, Genoa, Italy
⁴³Department of Haematology, St James's University Hospital, Leeds, United Kingdom
⁴⁴AORN "A. Cardarelli", Napoli, ITA
⁴⁵Stem Cell Transplantation and Cell Therapy Unit, AORN Santobono Pausilipon, Naples, Italy
⁴⁶UO Ematologia e terapie cellulari, IRCCS Ospedale Policlinico San martino, Genova, Italy
⁴⁷University Hospital Basel, Basel, Switzerland
⁴⁸King's College Hospital, London, GBR
⁴⁹Hematology Transplantation, Paris, France
⁵⁰French Reference Center for Aplastic Anemia, CHU Saint Louis, Paris, France
⁵¹King's College Hospital, London, United Kingdom
⁵²Hematology Unit, IRCCS G. Gaslini Children's Hospital, Genova, Italy
⁵³French Référence Center for Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria, Paris, France
⁵⁴Hematology and Transplantation Unit, Hôpital Saint Louis, AP-HP, Paris, France

Zoe K McQuilten, MBBS, PhD¹, Lucy C Fox, BSc, FRACP, FRCPA, MBBS^2,3, Stephane Heritier, PhD^4*, Vanessa Fox, BSc^4*, Lauren Young, PhD^4*, Piers Blombery, MBBS⁵, Ilona Cunningham, MBBS FRACP FRCPA⁶, Jennifer Curnow, MBBS, FRACP, FRCPA, PhD^7*, Alisa Higgins^2*, Devendra Hiwase, MD, MBBS, PhD, FRACP, FRCPA^8,9, Robin Filshie, PhD, FRACP, FRCPA¹⁰, Frank Caleb Firkin^11*, Paul Lacaze^12*, Kylie Mason, MBBS, PhD, FRACP, FRCPA¹³, Anthony K. Mills, MBBS, FRACP, FRCPA¹⁴, Dominic Pepperell^15*, Sushrut S. Patil^16*, Robyn Sutherland, BN, BSc^4*, William S. Stevenson, MBBS, PhD¹⁷, Jeffrey Szer, MBBS¹⁸, Le Thi Phuong Thao, PhD^19*, Neil A Waters, BSc^20*, Kate Wilson^21*, Stephen Ting, MBBS, FRACP, FRCPA, PhD²² and Erica M. Wood, MD²

¹Transfusion Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia
²Monash University, Melbourne, Australia
³Peter MacCallum Cancer Centre, Melbourne, Australia
⁴School of Public Health and Preventative Medicine, Monash University, Melbourne, Australia
⁵Peter Maccallum Cancer Centre, East Melbourne, VIC, Australia
⁶Haematology Department Concord Hospital, Concord and University of Sydney, Sydney, Australia
⁷Westmead Hospital, Sydney, AUS
⁸South Australian Health and Medical Research Institute, Adelaide, SA, Australia
⁹Royal Adelaide Hospital, Adelaide, SA, Australia
¹⁰St. Vincent's Hospital Melbourne, Fitzroy, VIC, AUS
¹¹St. Vincent's Hospital, Fitzroy, VIC, AUS
¹²Monash University, Melbourne, AUS
¹³Royal Melbourne Hospital, Parkville, VIC, AUS
¹⁴Division of Cancer Services, Princess Alexandra Hospital, Brisbane, QLD, Australia
¹⁵Fiona Stanley Hospital, Murdoch, AUS
¹⁶Department of Malignant Haematology & Stem Cell Transplantation, The Alfred Hospital, Melbourne, VIC, Australia
¹⁷Royal North Shore Hospital, Redfern, NSW, Australia
¹⁸Department of Clinical Haematology, Peter MacCallum Cancer Centre and The Royal Melbourne Hospital, Melbourne, VIC, Australia
¹⁹School of Public Health and Preventive Medicine, Monash University, Melbourne, AUS
²⁰Transfusion Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, AUS
²¹University of Sydney, Sydney, Australia
²²Department of Haematology, Eastern Health and Monash University, Elwood, VIC, Australia

Fengkui Zhang^1*, Xin Zhao¹, Hong Chang^2*, Bing Han^3*, Sujun Gao^4*, Miao Miao, MD^5*, Jianda Hu, PhD⁶, Yanjuan Lin^6*, Xinjian Liu^7*, Lina Zhang^7*, Chenghao Jin^8*, Yingmei Li^9*, Shengyun Lin^10*, Jinsong Jia^11*, Yi Wang^12*, Chunkang Chang^13*, Zheng Ge, MD, PhD¹⁴, Guangsheng He^15*, Ruixiang Xia^16*, Xiangjun Fu^17*, Yuhua Li^18*, Hong Liu^19*, Kai Sun^20*, Shunqing Wang^21*, Linghui Xia^22*, Weihua Zhang^23*, Runzi Li^24*, Junye Xiong^24* and Wanyi Zhai^24*

¹National Clinical Research Center for Blood Diseases, State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
²West China Hospital of Sichuan University, Chengdu, China
³Department of Hematology, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing, China
⁴The First Hospital of Jilin University, Changchun, China
⁵The First Affiliated Hospital of Soochow University, Suzhou, China
⁶Fujian Medical University Union Hospital, Fuzhou, China
⁷Henan Cancer Hospital, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China
⁸Jiangxi Provincial People's Hospital, Nanchang, China
⁹The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
¹⁰The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China
¹¹Peking University People’s Hospital, Beijing, China
¹²Shaanxi Provincial People's Hospital, Xi'an, China
¹³Shanghai Sixth People's Hospital, Shanghai, China
¹⁴Zhongda Hospital Southeast University, Nanjing, China
¹⁵The First Affiliated Hospital with Nanjing Medical University, NANJING, China
¹⁶The First Affiliated Hospital of Anhui Medical University, Hefei, China
¹⁷Hainan General Hospital, Haikou, China
¹⁸Zhujiang Hospital, Southern Medical University, Guangzhou, China
¹⁹Affiliated Hospital of Nantong University, Nantong, China
²⁰Henan Provincial People's Hospital, Zhengzhou, China
²¹Guangzhou First People's Hospital, Guangzhou, China
²²Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
²³First Hospital of Shanxi Medical University, Taiyuan, China
²⁴Jiangsu Hengrui Pharmaceuticals Co., Ltd., Shanghai, China

Camilla Frieri^1,2*, Dirk-Jan Eikema Sr.^3*, Joe Tuffnell^4*, Brian Piepenbroek^5*, Malek Benakli, MD^6*, Grzegorz Helbig, MD, PhD^7*, Thomas Cluzeau, MD, PhD^8*, Cécile Renard, MD^9*, Philippe Lewalle^10*, Victoria Potter^11*, Krzysztof Kalwak Sr.^12*, Johan Maertens, MD, PhD^13*, Gerard Michel, MD, PhD^14*, Andrew Bruce McDonald, MBChB¹⁵, Péter Pál Reményi, MD^16*, Ladislav Sopko^17*, Kazimierz Halaburda^18*, Depei Wu, MD, PhD¹⁹, Zubeyde Nur Ozkurt^20*, Xavier Poiré, MD, PhD^21*, Morag Griffin, MBChB, MRCP^22*, Mahmoud Aljurf^23*, Ashrafsadat Mousavi^24*, Jose Antonio Pérez-Simón, MD, PhD²⁵, Henrik Sengeloev^26*, Ben Carpenter, MD^27*, Eric Deconinck²⁸, Arancha Bermúdez^29*, Stéphanie Nguyen-Quoc, MD, PhD^30*, Matteo Parma, MD^31*, Ibrahim Yakoub-Agha, MD, PhD^32*, Shankara Paneesha^33*, Lutz Peter Hermann Mueller, MD^34*, Regis Peffault De Latour^35,36*, Austin G. Kulasekararaj, MD, MBBS, FRCPath, MRCP³⁷ and Antonio M Risitano, MD, PhD^38,39

¹Hematology and Transplant Unit, A.O.R.N. S. Giuseppe Moscati, Avellino, Italy
²European Bone Marrow Transplantation society, Severe Aplastic Anemia Working Party, Leiden, Netherlands
³EBMT Statistical Unit, Leiden, Netherlands
⁴EBMT Leiden Study Unit, Leiden, Netherlands
⁵EBMTClinical Study Unit, Leiden, Netherlands
⁶Pierre and Marie Curie Center, Algiers, Algeria
⁷Department of Hematology and Bone Marrow Transplantation, Silesian Medical Academy, Katowice, Poland
⁸Centre Hospitalier Universitaire de Nice, Nice, France
⁹Institute of Hematology and Pediatric Oncology, Lyon, France
¹⁰Jules Bordet Institute (HUB/ULB), Brussels, Belgium
¹¹Dept. of Haematological Medicine, King's College Hospital NHS Foundation Trust, London, United Kingdom
¹²Fundacja "Na Ratunek Dzieciom z Choroba Nowotworowa", Wroclaw, Dolnoslaskie, Poland
¹³Department of Hematology, University Hospital Gasthuisberg, Leuven, Belgium
¹⁴CHU de Marseille Hôpital de la Timone Enfants, Marseille, France
¹⁵This, Randburg, ZAF
¹⁶Department of Hematology and Stem Cell Transplantation, Central Hospital of Southern Pest, National Institute of Hematology and Infectious Diseases, Budapest, Hungary
¹⁷University Hospital, Bratislava, Slovakia
¹⁸Institute of Hematology and Transfusion Medicine, Warsaw, Poland
¹⁹Department of Hematology, Collaborative Innovation Center of Hematology, Institute of Blood and Marrow Transplantation, the First Affiliated Hospital of Soochow University, Suzhou, China
²⁰Gazi University Faculty of Medicine, Ankara, Turkey
²¹Section of Hematology, Institut Roi Albert II, Cliniques Universitaires St-Luc, Brussels, Belgium
²²Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
²³King Faisal Specialist Hospital & Research Centre, Oncology (Section of Adult Haematolgy/BMT) – Riyadh, Saudi Arabia, Riyadh, Saudi Arabia
²⁴Shariati Hospital, Teheran, Iran (Islamic Republic of)
²⁵Department of Hematology, Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS), CSIC, University of Sevilla, Sevilla, Spain
²⁶Rigshospitalet, Copenhagen, Denmark
²⁷University College London Hospitals NHS Foundation Trust, London, United Kingdom
²⁸Université de Franche-Comté, EFS, INSERM, UMR RIGHT, Besançon, France
²⁹Department of Hematology, Hospital Universitario Marqués de Valdecilla, Cantabria, Spain
³⁰Hematology Department, Pitié-Salpêtrière University Hospital, AP-HP, Paris, France
³¹Hematology Department, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy
³²CHU de Lille, Université de Lille, INSERM U1286, Infinite, 59000, Lille, France
³³Birmingham Centre for Cellular Therapy and Transplant (BCCTT), Birmingham, United Kingdom
³⁴Department of Internal Medicine IV, Martin-Luther-Universität Halle-Wittenberg, Halle, Germany
³⁵BMT unit, Hôpital Saint-Louis,, Paris, France
³⁶French Référence Center for Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria, Paris, France
³⁷King’s College Hospital-NHS Foundation Trust, NIHR/Wellcome King’s Clinical Research Facility, and King’s College London, London, United Kingdom
³⁸Severe Aplastic Anemia Working Party, European Group for Blood and Marrow Transplantation (EBMT), Leiden, Netherlands
³⁹Hematology and BMT Unit, AORN San Giuseppe Moscati, Avellino, Italy

Christopher Patriquin^1*, Jun-Ho Jang, MD., PhD.², Lisa Aurand³, Deepak Taneja^3*, Andrew Magyar^3*, Bradley Dain^3*, Karoline Meagher^3*, Lorah Perlee^3*, Amal Souttou^3* and Morag Griffin, MBChB, MRCP^4*

¹University Health Network, Toronto General Hospital, Toronto, ON, Canada
²Samsung Medical Center, Seoul, Korea, Republic of (South)
³Regeneron Pharmaceuticals, Inc., Tarrytown, NY
⁴St James’s University Hospital, Leeds, United Kingdom