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102.O1.6 102. Iron Homeostasis and Biology: New Insights into Iron-related Proteins in Erythropoiesis and Inflammation

Symposia: Iron Homeostasis and Biology Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Research, Fundamental Science, Iron Deficiency, Translational Research, Iron Overload, Drug development, Genetic Disorders, Thalassemia, Hemoglobinopathies, Hematopoiesis, Diseases, Immune mechanism, Treatment Considerations, Metabolism, Biological Processes, Myeloid Malignancies, Metabolic Disorders, Molecular biology, Study Population, Animal model, Pathogenesis, Maternal Health
Saturday, December 7, 2024: 9:30 AM-11:00 AM
Room 29 (San Diego Convention Center)
Moderators:
Imo J. Akpan, MD, Columbia University and Laura Silvestri, PhD, San Raffaele Scientific Institute %26 Vita-Salute Uni.
Disclosures:
Akpan: Pharmacosmos Therapeutics Inc: Consultancy, Honoraria, Speakers Bureau. Silvestri: Novo Nordisk: Consultancy, Honoraria.

In this session we will explore the complex mechanisms that modulate erythropoiesis and inflammation, focusing on the emerging role of iron-related proteins. These include the unconventional function of the iron storage protein ferritin in regulating EPO receptor signaling, the new insights into the reciprocal regulation between inflammation and hepcidin-ferroportin function, the unexpected role of the RNA-binding protein RBM28 in the modulation of heme synthesis via ferrochelatase, the identification of a novel and promising drug for erythropoietic protoporphyria, and the effect of maternal iron overload on epigenetic changes in fetal brain.
9:30 AM

Ranjit Sahu1*, Kurt Langberg1*, Lorrie Delehanty1*, Kamaleldin E Elagib1*, Deepika Kotay1*, James Zimring1, Angelo D'Alessandro, PhD2 and Adam Goldfarb1*

1Department of Pathology, University of Virginia Health Sciences Center, Charlottesville, VA
2Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO

9:45 AM

Maayan Levy1*, Huihui Li2,3, Andrew Dunbar, MD4,5, Zixing Huang2,3*, Young Park5*, Min Lu6, Pinanong Na Phattalung1*, Marina Planoutene1*, Carla Casu7*, Stefano Rivella, PhD7, Shuling Guo8*, Ross L Levine, MD5, Ronald Hoffman, MD9 and Yelena Ginzburg, MD1

1Division of Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
2Emergency Medicine, Icahn School of Medicine at Mount Sinai, New York, NY
3Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY
4Department of Hematopoietic Biology & Malignancy, The University of Texas MD Anderson Cancer Center, Houston, TX
5Memorial Sloan Kettering Cancer Center, New York, NY
6The Tisch Cancer Institute, Division of Hematology & Oncology, Icahn School of Medicine at Mount Sinai, New York, NY
7Children's Hospital of Philadelphia, Philadelphia, PA
8Ionis Pharmaceuticals, Inc, Carlsbad, CA
9Division of Hematology & Oncology, Icahn School of Medicine at Mount Sinai, New York, NY

10:00 AM

Oriana Marques1*, Natalie Horvat2*, Laura Zechner3*, Silvia Colucci2*, Richard Sparla2*, Stefan Zimmermann2*, Christopher Neufeldt2*, Sandro Altamura2*, Qiu Ruiyue3*, Katja Müdder3*, Guenter Weiss4*, Matthias Hentze5* and Martina U. Muckenthaler6

1Universitatsklinikum Heidelberg, Heidelberg, DEU
2University of Heidelberg, Heidelberg, DEU
3University of Heidelberg, Heidelberg, Germany
4Medical University of Innsbruck, Innsbruck, AUT
5European Molecular Biology Laboratory, Heidelberg, Germany
6University of Heidelberg, Heidelberg, Baden-Württemberg, Germany

10:15 AM

Lucia Lee1*, Vida Zhang, PhD1*, Veena Sangkhae, PhD1, Yue He2*, Jacob Shine2*, Tomas Ganz, MD, PhD3, James F Collins2* and Elizabeta Nemeth, PhD3

1Center for Iron Disorders, David Geffen School of Medicine at UCLA, Los Angeles, CA
2University of Florida, Gainesville, FL
3Center for Iron Disorders, University of California, Los Angeles, Los Angeles, CA

10:30 AM

Bhavik Shah1*, Edmond Huang, PhD2*, Yvonne Pak2*, Chris Henry2*, Sunita Babbar2*, Athiwat Hutchaleelaha2*, Robert Zamboni2*, Xiaochao Ma3*, Pete Schmidt2*, Morgan Paull2* and Uma Sinha, PhD2

1BridgeBio Pharma, winchester, MA
2BridgeBio Pharma, Palo Alto, CA
3University of Pittsburgh, Pittsburgh, PA

10:45 AM

Xinshu Xie1*, Ailin Zou1*, Kang Liu2*, Lu Liu, PhD3 and Yang Mei, PhD1*

1The affiliated Xiangtan Central Hospital of Hunan University, Hunan Provincial Key Laboratory of Animal Model and Molecular Medicine, School of Biomedical Sciences, Hunan University, Changsha, China
2The affiliated Xiangtan Central Hospital of Hunan University, Changsha, China
3School of Biomedical Sciences, Hunan University, Changsha, China

*signifies non-member of ASH