Symposia: Iron Homeostasis and Biology
Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Research, Fundamental Science, Iron Deficiency, Translational Research, Iron Overload, Drug development, Genetic Disorders, Thalassemia, Hemoglobinopathies, Hematopoiesis, Diseases, Immune mechanism, Treatment Considerations, Metabolism, Biological Processes, Myeloid Malignancies, Metabolic Disorders, Molecular biology, Study Population, Animal model, Pathogenesis, Maternal Health
Type: Oral
Hematology Disease Topics & Pathways:
Research, Fundamental Science, Iron Deficiency, Translational Research, Iron Overload, Drug development, Genetic Disorders, Thalassemia, Hemoglobinopathies, Hematopoiesis, Diseases, Immune mechanism, Treatment Considerations, Metabolism, Biological Processes, Myeloid Malignancies, Metabolic Disorders, Molecular biology, Study Population, Animal model, Pathogenesis, Maternal Health
Saturday, December 7, 2024: 9:30 AM-11:00 AM
Room 29
(San Diego Convention Center)
Moderators:
Imo J. Akpan, MD, Columbia University
and
Laura Silvestri, PhD, San Raffaele Scientific Institute %26 Vita-Salute Uni.
Disclosures:
Akpan: Pharmacosmos Therapeutics Inc: Consultancy, Honoraria, Speakers Bureau. Silvestri: Novo Nordisk: Consultancy, Honoraria.
In this session we will explore the complex mechanisms that modulate erythropoiesis and inflammation, focusing on the emerging role of iron-related proteins. These include the unconventional function of the iron storage protein ferritin in regulating EPO receptor signaling, the new insights into the reciprocal regulation between inflammation and hepcidin-ferroportin function, the unexpected role of the RNA-binding protein RBM28 in the modulation of heme synthesis via ferrochelatase, the identification of a novel and promising drug for erythropoietic protoporphyria, and the effect of maternal iron overload on epigenetic changes in fetal brain.
9:30 AM
10:00 AM
10:15 AM
10:30 AM
10:45 AM
See more of: Oral and Poster Abstracts
*signifies non-member of ASH