Fieke W Hoff, MD, PhD¹, Ying Huang, MS, MA², Rina Li Welkie, MPH³, Ronan T. Swords, MD, PhD, FRCP, FRCPath⁴, Elie Traer, MD, PhD⁵, Eytan M. Stein⁶, Tara L Lin, MD⁷, Prapti A. Patel, MD⁸, Robert H. Collins, MD⁹, Maria R. Baer, MD¹⁰, Vu H. Duong, MD, MS¹⁰, William Blum, MD¹¹, Martha Arellano¹², Wendy Stock, MD¹³, Olatoyosi Odenike¹⁴, Robert L. Redner, MD¹⁵, Tibor J. Kovacsovics, MD¹⁶, Michael W. Deininger, MD, PhD¹⁷, Joshua F. Zeidner, MD¹⁸, Rebecca Olin, MD¹⁹, Catherine C. Smith, MD²⁰, James M. Foran, MD²¹, Gary J. Schiller, MD²², Emily K Curran, MD²³, Kristin L Koenig, MD²⁴, Nyla A. Heerema, PhD^25*, Timothy Chen, PhD^26*, Molly Martycz^26*, Mona Stefanos, MD²⁶, Sonja Gullen Marcus, MPH^27*, Leonard Rosenberg^27*, Brian J. Druker, MD²⁸, Ross L Levine, MD²⁹, Amy Burd, PhD³⁰, Ashley Owen Yocum, PhD²⁷, Uma M. Borate, MD³¹, Alice Mims, MD³², John C. Byrd, MD³³ and Yazan F. Madanat, MD⁹

¹UT Southwestern Medical Center, Dallas, TX
²Division of Hematology, The Ohio State University, Columbus, OH
³The James Cancer Center, The Ohio State University Wexner Medical Center, Columbus, OH
⁴Knight Cancer Institute, Oregon Health and Science University, Portland, OR
⁵Knight Cancer Institute, Oregon Health & Sciences University, Portland, OR
⁶Leukemia Service, Department of Medicine, Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY
⁷Division of Hematologic Malignancies and Cellular Therapeutics, The University of Kansas Medical Center, Westwood, KS
⁸University of Texas Southwestern Medical Center, Westlake, TX
⁹Hematologic Malignancies and Cellular Therapy, University of Texas Southwestern Medical Center, Dallas, TX
¹⁰Department of Medicine, University of Maryland School of Medicine, Baltimore, MD
¹¹Winship Cancer Institute of Emory University, Atlanta, GA
¹²Emory University School of Medicine, Atlanta, GA
¹³University of Chicago Medicine, Chicago, IL
¹⁴The University of Chicago Medicine and Comprehensive Cancer Center, Chicago, IL
¹⁵University of Pittsburgh Medical Center, Pittsburgh, PA
¹⁶University of Utah, Salt Lake City, OR
¹⁷Division of Hematology and Hematologic Malignancies, The University of Utah, Huntsman Cancer Institute, Salt Lake City, UT
¹⁸University of North Carolina, Lineberger Comprehensive Cancer Center, Chapel Hill, NC
¹⁹University of California San Francisco, San Francisco, CA
²⁰Department of Medicine, Division of Hematology/Oncology, University of California San Francisco, San Francisco, CA
²¹Hematology/Oncology, Mayo Clinic, Jacksonville, FL
²²Hematological Malignancy/ Stem Cell Transplant Program, David Geffen School of Medicine, UCLA, Los Angeles, CA
²³University of Cincinnati, Cincinnati, OH
²⁴Division of Hematology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH
²⁵Ohio State University, Columbus, OH
²⁶The Ohio State University, Columbus, OH
²⁷Leukemia and Lymphoma Society, Rye Brook, NY
²⁸Oregon Health & Science University, Portland, OR
²⁹Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
³⁰Leukemia and Lymphoma Society, White Plains, NY
³¹Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH
³²Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH
³³Department of Internal Medicine, University of Cincinnati, Cincinnati, OH

Sarah Elizabeth Mudra, MD^1*, Paul Sackstein, MD^1*, Lacey Scott Williams, MD², Garrett Diltz, MD³, Rachel Zemel, MD^1*, Ashwin Kumar, DO^4*, Purnima Sravanti Teegavarapu, MD⁵, Martha P. Mims, MD, PhD⁵, Catherine Lai, MD⁶, Kimberley Doucette, MD¹ and Gustavo A. Rivero, MD^1*

¹Lombardi Comprehensive Cancer Center, MedStar Georgetown University Hospital, Washington, DC
²Lombardi Comprehensive Cancer Center, MedStar Georgetown University Hospital, Alexandria, VA
³Lombardi Comprehensive Cancer Center, MedStar Georgetown University Hospital, Boston, MA
⁴Lombardi Cancer Institute, MedStar Georgetown University Hospital, Washington, DC
⁵Section of Hematology-Oncology, Department of Medicine, Baylor College of Medicine, Houston, TX
⁶Abramson Cancer Center, Georgetown University Hospital, Washington, DC

Nathaniel J Buteyn, PhD^1*, Connor Burke^2*, Eve Gardner^2*, Vincent J Sartori^2*, Rhonda E Ries, MA^3*, Todd A. Alonzo, PhD^4,5*, Soheil Meshinchi, MD, PhD⁶ and Timothy Triche Jr., PhD^2*

¹Van Andel Institute, Grand Haven, MI
²Van Andel Institute, Grand Rapids, MI
³Translational Sciences and Therapeutics, Fred Hutchinson Cancer Center, Seattle, WA
⁴Univ. of Southern California Keck School of Med., Monrovia, CA
⁵Children's Oncology Group, Monrovia, CA
⁶Translational Sciences and Therapeutics, Fred Hutchinson Cancer Research Center, Seattle, WA

Seo-Ho Lee^1*, Dennis M Bonal, MSc, BSc², Diana Olguta Treaba, MD^3*, Anna Dorota Chorzalska, PhD^4*, Makayla Pardo^5*, John L. Reagan, MD⁶, Adam J Olszewski, MD⁷ and Patrycja M. Dubielecka, PhD⁴

¹Brown University, Amherst, MA
²Pathobiology Graduate Program, Brown University, Douglas, MA
³Department of Pathology and Laboratory Medicine, Providence, RI
⁴Signal Transduction Lab, Rhode Island Hospital, Providence, RI
⁵Pathobiology Graduate Program, Brown University, Providence, RI
⁶Legorreta Cancer Center of Brown University, Providence, RI
⁷Brown University, Providence, RI

Heather C Murray^1*, Anoop K Enjeti, MBBS FRCPA MD MRCP^2,3,4, Saumya Samaraweera, PhD⁵, Joshua S Brzozowski^1*, Kasey Miller^1*, Richard J D'Andrea, PhD, BSc⁶ and Nicole M Verrills^7*

¹School of Biomedical Sciences and Pharmacy; College of Health, Medicine and Wellbeing, and Precision Medicine Research Program, Hunter Medical Research Institute, University of Newcastle, Callaghan, Australia
²School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, Australia
³Calvary Mater Hospital, Waratah, NSW, AUS
⁴Precision Medicine Research Program, Hunter Medical Research Institute, NSW, Australia
⁵Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, University of South Australia, Adelaide, SA, AUS
⁶Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA, Australia, Adelaide, SA, AUS
⁷School of Biomedical Sciences and Pharmacy; College of Health, Medicine and Wellbeing; and Precision Medicine Research Program, Hunter Medical Research Institute, University of Newcastle, Callaghan, Australia

Monika Toma, PhD^1*, Adam Karami^1*, Margaret Nieborowska-Skorska, MD, PhD^1*, Kumaraswamy Chitrala, PhD^1*, Peter Valent, MD² and Tomasz Skorski, MD, PhD¹

¹Fels Cancer Institute for Personalized Medicine, Temple University School of Medicine, Philadelphia, PA
²Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria

Fadimana Kaya, MSc, BSc^1*, Findlay Bewicke-Copley, PhD, MSc, BSc^2*, Pedro Casado Izquierdo, PhD^3*, Jiexin Zheng, MBBS, MA, MRCP^4*, Juho Jalmari Miettinen, PhD^5*, Naeem Khan, PhD^6*, Szilvia Krizsán^7*, Joseph J Saad, MSc^8*, Vincent-Philippe Lavallée^9*, Alexis Nolin-Lapalme^10*, Josée Hébert, MD^11*, Janet Matthews^12*, Marianne Grantham^13*, Doriana Di Bella^14*, Krister Wennerberg, PhD^15*, Alun Parsons^16*, John G. Gribben, MD, DSc¹⁷, James D. Cavenagh, MD¹⁸, Sylvie D Freeman¹⁹, Csaba Bödör, PhD^7*, Guy Sauvageau, MD/PhD²⁰, Caroline A. Heckman, PhD²¹, Jun Wang^22*, Jean-Baptiste Cazier^23*, David Taussig, PhD, MRCP, FRCPath²⁴, Dominique Bonnet, PhD²⁵, Pedro R Cutillas, PhD²², Kevin Rouault-Pierre, PhD^26*, Jude Fitzgibbon, PhD^27* and Ana Rio-Machin, PhD^22*

¹Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, ENG, United Kingdom
²Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom
³Centre for Genomics and Computational Biology, Barts Cancer Institute, London, ENG, GBR
⁴Centre for Genomics and Computationa Biology, Barts Cancer Institute, London, GBR
⁵Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland
⁶Institute of Immunology and Immunotherapy, Birmingham, ENG, GBR
⁷HCEMM-SU Molecular Oncohematology Research Group, Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary
⁸Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland
⁹Centre Hospitalier Universitaire Sainte-Justine Research Center, Montreal, QC, CAN
¹⁰Institute for Research in Immunology and Cancer, Montreal, Canada
¹¹Institut de recherche en Immunologie et Cancer, Université de Montréal, Montreal, QC, Canada
¹²CR UK, LONDON, GBR
¹³Barts Health NHS Trust, LONDON, GBR
¹⁴Barts Cancer Institute, Queen Mary University of London, London, GBR
¹⁵Biotech Research & Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark
¹⁶HiLIFE – Helsinki Institute of Life Science, Institute for Molecular Medicine Finland – FIMM, Helsinki, Finland
¹⁷Barts Cancer Institute, Queen Mary University of London, London, United Kingdom
¹⁸Department of Haematology, St. Bartholomew's Hospital, London, GBR
¹⁹University of Birmingham, Cheltenham, United Kingdom
²⁰University of Montreal, Montreal, QC, CAN
²¹Institute for Molecular Medicine Finland, Institute For Molecular Medicine Finland FIMM, Helsinki, Finland
²²Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom
²³Centre for Computational Biology, Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom
²⁴The Royal Marsden Hospital and Institute of Cancer Research, London, United Kingdom
²⁵The Francis Crick Institute, London, GBR
²⁶Centre for Haemato-Oncology, Barts Cancer Institute, London, United Kingdom
²⁷AstraZeneca, Waltham, MA

Andres E Quesada, MD^1*, Gokce A. Toruner, MD PhD^1*, Zhenya Tang, MD PhD^1*, Shimin Hu^1*, Jie Xu, MD PhD^1*, Shaoying Li, MD^1*, Farhad Ravandi, MD, MBBS², Hagop M. Kantarjian, MD², M. James You, MD, PhD¹, L. Jeffrey Medeiros, MD³ and Guilin Tang, MD PhD^1*

¹Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX

Bahga Katamesh^1*, Amrutha Mittapalli^1*, Rong He, MD², David Viswanatha, MD¹, Dragan Jevremovic, MD, PhD^2*, Mehrdad Hefazi, MD¹, Antoine Saliba, MD³, Abhishek A Mangaonkar, MBBS³, Kebede Begna, MD³, William J. Hogan, MD³, Naseema Gangat, MBBS³, Mrinal M. Patnaik, MD, MBBS⁴, Mithun V Shah, MD, PhD³, Ayalew Tefferi, MD³, Mark R. Litzow, MD³, Hassan Alkhateeb, MD^3* and Aref Al-Kali, MD³

¹Mayo Clinic, Rochester, MN
²Division of Hematopathology, Mayo Clinic, Rochester, MN
³Division of Hematology, Mayo Clinic, Rochester, MN
⁴Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN

Courtney D. DiNardo, MD, MSc¹, Dylan Marchione, PhD^2*, Michael Heuser, MD³, Jianan Hui, PhD^2*, Diego Gianolio, PhD^2*, Scott Daigle, MSc^2*, Sung Choe, PhD^2*, Prapti Patel, MD^2*, Stephane De Botton, MD, PhD^4* and Hartmut Dohner, MD⁵

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Servier Pharmaceuticals LLC, Boston, MA
³Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
⁴Department of Hematology, Institut Gustave Roussy, Villejuif, France
⁵Department of Internal Medicine III, Ulm University Medical Center, Ulm, Germany

Rhonda E Ries, MA^1*, Xiaotu Ma, PhD², Claudia Tregnago, PhD^3*, Todd A. Alonzo, PhD^4*, Jim Wang, MS^4*, Tiffany Hylkema, BS^1*, Benjamin J Huang, MD⁵, Alireza Torabi, MD, PhD⁶, Jack H Peplinski, BS^1*, Logan K Wallace^7*, Richard Aplenc, MD, PhD⁸, Alan S Gamis, MD, MPH⁹, Katherine Tarlock, MD¹⁰, Franco Locatelli, MD, PhD¹¹, Martina Pigazzi, PhD^3* and Soheil Meshinchi, MD, PhD¹²

¹Translational Sciences and Therapeutics, Fred Hutchinson Cancer Center, Seattle, WA
²St. Jude Children's Research Hospital, Memphis, TN
³Department of Women's and Children's Health, Onco-hematology lab and clinic, University of Padova, Padova, Italy
⁴Children's Oncology Group, Monrovia, CA
⁵Department of Pediatrics, University of California, San Francisco, San Francisco, CA
⁶Fred Hutchinson Cancer Center, Seattle, WA
⁷Translational Science and Therapeutics, Fred Hutchinson Cancer Center, Seattle, WA
⁸Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA
⁹Hematology/Oncology/BMT, Children's Mercy Kansas City, Kansas City, MO
¹⁰Division of Pediatric Hematology, Oncology, Bone Marrow Transplant & Cellular Therapy, Seattle Children's Hospital, Seattle, WA
¹¹IRCCS Bambino Gesù Children’s Hospital, Catholic University of the Sacred Heart, Rome, Italy
¹²Translational Sciences and Therapeutics, Fred Hutchinson Cancer Research Center, Seattle, WA

Ruwan Gunaratne, MD, PhD^1,2, Crystal Zhou^1*, Jesse W. Tai, MS, BS¹, Matthew Schwede, MD¹, Kailee Tanaka^1*, Matthew Alkaitis, MD, PhD^3*, Raymond Yin, MS^4*, Brian J. Sworder, MD, PhD⁵, Gabriel N. Mannis^1,6, Ravi Majeti, MD^1,7,8, Michael S. Khodadoust, MD^9*, David M. Kurtz, MD, PhD^1,2,8 and Tian Y. Zhang, MD, PhD^1,8

¹Division of Hematology, Department of Medicine, Stanford University, Stanford, CA
²Division of Oncology, Department of Medicine, Stanford University, Stanford, CA
³Department of Medicine, Stanford University, Stanford, CA
⁴University of California San Francisco, San Francisco, CA
⁵Division of Oncology, Department of Medicine, Stanford University, Irvine, CA
⁶Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA
⁷Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA
⁸Stanford Cancer Institute, Stanford, CA
⁹Departments of Dermatology and Medicine - Oncology, Stanford University School of Medicine, Stanford, CA

Naveed Ali, MBBS¹, Othus Megan, PhD^2*, Eduardo Rodríguez-Arbolí, MD^3*, Corentin Orvain^3*, Filippo Milano, MD³, Brenda M. Sandmaier, MD³, Chris Davis^1*, Ryan S. Basom^1*, Frederick R. Appelbaum, MD¹ and Roland B. Walter, MD, PhD, MS^4,5,6

¹Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA
²Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA
³Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA
⁴Translational Science and Therapeutics Division, Fred Hutchinson Cancer Research Center, Seattle, WA
⁵Division of Hematology, Department of Medicine, University of Washington, Seattle, WA
⁶Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA

Wenbing Duan^1*, Jinsong Jia, MD^1*, Jing Wang, MD^1*, Xiaohong Liu^1*, Lizhong Gong^1*, WenJing Yu, MD^1*, Xiaolu Zhu, MD^1*, Zhao Ting^1*, Qian Jiang, MD¹, Guorui Ruan, MD^1*, Xiaosu Zhao^1*, Yu Wang, MD^2*, Hongxia Shi, MD^1*, Lanping Xu, MD^1*, Xiaohui Zhang^3*, Xiaojun Huang, MD^1* and Hao Jiang^4*

¹Peking University People’s Hospital,Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing, China
²Peking University People’s Hospital, Beijing, China
³Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China
⁴Peking University People’s Hospital,Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, BEIJING, AL, China

Graeme Murray, M.D., Ph.D.^1*, Ian Bouligny, M.D.², Thuy Ho, M.D.^1*, Juhi Gor, M.D.^1* and Keri Maher, DO¹

¹Massey Cancer Center, Virginia Commonwealth University, Richmond, VA
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX

Sibylle Cocciardi, PhD^1*, Nina Weiß^1*, Maral Saadati^2*, Sabrina Skambraks^1*, Daniela Weber^1*, Isabelle Schneider^1*, Annika Meid^1*, Sophia Aicher^1*, Kathrin Bengesser-Kuhn^1*, Andrea Corbacioglu^1*, Verena I. Gaidzik¹, Frauke Theis, MD^1*, Walter Fiedler, MD³, Michael Kühn^4*, Ulrich Germing^5*, Karin T. Mayer^6*, Michael Lübbert, MD⁷, Felicitas Thol⁸, Michael Heuser, MD⁸, Arnold Ganser⁸, Lars Bullinger⁹, Axel Benner^10*, Hartmut Döhner, MD¹ and Konstanze Döhner¹

¹Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany
²German Cancer Research Center Heidelberg, Heidelberg, Germany
³Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
⁴Johannes Gutenberg-University, Mainz, Germany
⁵Department of Hematology, Oncology and Clinical Immunology, Universitatsklinik Dusseldorf, Dusseldorf, Germany
⁶University Hospital of Bonn, Bonn, Germany
⁷University Medical Center Freiburg, Freiburg, Germany
⁸Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
⁹Department of Hematology, Oncology, and Cancer Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany
¹⁰Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany

Emily K Curran, MD¹, Deedra Nicolet², Alejandro Otero-Bravo^3*, Krzysztof Mrózek, MD, PhD⁴, Ben Kelly^5*, Christopher J. Walker, PhD^6*, Jill Buss, BS⁴, Andrea Laganson, MS^4*, Yazan Abu-Shihab, MD^7*, Alice Mims, MD⁸, William Blum, MD⁹, Jonathan E Kolitz, MD¹⁰, Bayard L Powell, MD¹¹, Geoffrey L Uy, MD¹², Wendy Stock, MD¹³, Richard M Stone, MD¹⁴, Andrew J Carroll, PhD¹⁵, John C. Byrd, MD¹⁶, Elaine R Mardis, PhD^3,6* and Ann-Kathrin Eisfeld, MD*²

¹Division of Hematology/Oncology, University of Cincinnati Cancer Center, Cincinnati, OH
²Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University, Columbus, OH
³Nationwide Children's Hospital, Columbus, OH
⁴Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University Comprehensive Cancer Center, Columbus, OH
⁵Nationwide Children's Hospital and Ohio State University College of Medine, Columbus, OH
⁶The Ohio State University Comprehensive Cancer Center, Columbus, OH
⁷The Ohio State University, Columbus, OH
⁸Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH
⁹Winship Cancer Institute of Emory University, Atlanta, GA
¹⁰Zucker School of Medicine at Hofstra/Northwell, Zuckerberg Cancer Center, Lake Success, NY
¹¹Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, NC
¹²Division of Oncology, Washington University School of Medicine, Saint Louis, MO
¹³Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL
¹⁴Dana-Farber Cancer Institute, Boston, MA
¹⁵Department of Genetics, University of Alabama at Birmingham, Birmingham, AL
¹⁶Department of Internal Medicine, University of Cincinnati, Cincinnati, OH

Kevin Wells Tien, MD¹, Jennifer M. Geris, PhD, MPH^1,2*, Chi-Fan Lin^2*, Charles Cook^2*, Olga Taylor^2*, Maria Isabel Castellanos, MD^3*, Van Thu Huynh⁴, Kathleen Ludwig, MD^5*, Laura J. Klesse, MD, PhD^5*, Sandi Pruitt, PhD, MPH^6*, Amy Hughes, PhD^6*, Kenneth Matthew Heym, MD^7*, Timothy Griffin, MD^8*, Rodrigo Erana, MD^1*, Juan C. Bernini, MD^1*, Karen R. Rabin, MD, PhD⁹, Michael E. Scheurer, PhD^1,2, Philip J. Lupo, PhD^10* and Maria Monica Gramatges, MD, PhD¹¹

¹Department of Pediatrics, Baylor College of Medicine, Houston, TX
²Baylor College of Medicine, Houston, TX
³University of California San Francisco, San Francisco, CA
⁴Division of Oncology, Children's Hospital of Orange County, Orange, CA
⁵University of Texas Southwestern, Dallas, TX
⁶Peter O’ Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX
⁷Department of Pediatrics, Cook Children's Medical Center, Fort Worth, TX
⁸Department of Hematology-Oncology, The Children’s Hospital of San Antonio/Baylor College of Medicine, San Antonio, TX
⁹Department of Pediatrics, Baylor College of Medicine, Baylor College of Medicine TX Children's Cancer Center, Houston, TX
¹⁰Division of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX
¹¹Texas Children's Hospital, Houston, TX

Richard J Marrero, PharmD¹, Vivek M. Shastri, PhD², Richard Aplenc, MD, PhD³, Todd Cooper, DO⁴, Todd A. Alonzo, PhD^5*, Alan S Gamis, MD, MPH⁶, Jim Wang, MS^7*, Soheil Meshinchi, MD, PhD⁸, E. Anders Kolb, MD⁹ and Jatinder K. Lamba, PhD¹⁰

¹Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, GAINESVILLE, FL
²Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, FL
³Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA
⁴Division of Pediatric Hematology, Oncology, Bone Marrow Transplant & Cellular Therapy, Seattle Children's Hospital, Seattle, WA
⁵Univ. of Southern California Keck School of Med., Monrovia, CA
⁶Hematology/Oncology/BMT, Children's Mercy Kansas City, Kansas City, MO
⁷Children's Oncology Group, Monrovia, CA
⁸Translational Sciences and Therapeutics, Fred Hutchinson Cancer Research Center, Seattle, WA
⁹Leukemia & Lymphoma Society, Bronx, NY
¹⁰UF Health Cancer Center, University of Florida, Gainesville, FL

Corentin Orvain^1*, Naveed Ali, MBBS², Megan Othus, PhD³, Eduardo Rodríguez-Arbolí, MD^4*, Filippo Milano, MD⁵, Brenda M. Sandmaier, MD⁶, Bart L. Scott, MD⁷, Frederick R. Appelbaum, MD⁷ and Roland B. Walter, MD, PhD, MS⁸

¹Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Angers, France
²Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA
³Public Health Science Division, Fred Hutchinson Cancer Center, Seattle, WA
⁴Department of Hematology, Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla, University of Seville, Seville, Spain
⁵Fred Hutchinson Cancer Research Center, Seattle, WA
⁶Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA
⁷Fred Hutchinson Cancer Center, Seattle, WA
⁸Translational Science and Therapeutics Division, Fred Hutchinson Cancer Research Center, Seattle, WA

Gege Gui, ScM^1,2, Laura W Dillon, PhD^1*, Niveditha Ravindra, MD^1*, Pranay S. Hegde, BS^1*, Georgia Andrew, BSc^1*, Devdeep Mukherjee, PhD^1*, Zoe Wong, BS^1*, Jeffery J. Auletta, MD^3,4, Firas El Chaer, MD⁵, Evan C. Chen, MD⁶, Yi-Bin Chen, MD, MS⁷, Adam Corner, PhD^8*, Steven M. Devine, MD⁹, Sunil G. Iyer, MD¹⁰, Antonio M. Jimenez Jimenez, MD, MSc^11*, Marcos de Lima, MD^12*, Mark R. Litzow, MD¹³, Partow Kebriaei, MD¹⁴, Wael Saber, MD, MS^3,15, Stephen R. Spellman, MBS^3,16*, Scott L. Zeger, PhD^2*, Kristin M. Page, MD^3,15 and Christopher S. Hourigan, DM, DPhil^1,17

¹Laboratory of Myeloid Malignancies, Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, MD
²Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD
³Center for International Blood and Marrow Transplant Research, Minneapolis, MN
⁴Hematology/Oncology/Bone Marrow Transplant and Infectious Diseases, Nationwide Children's Hospital, Columbus, OH
⁵Department of Medicine, Division of Hematology and Oncology, University of Virginia Comprehensive Cancer Center, Charlottesville, VA
⁶Dana-Farber Cancer Institute, Boston, MA
⁷Massachusetts General Hospital, Boston, MA
⁸Bio-Rad Laboratories, Pleasanton, CA
⁹CIBMTR® (Center for International Blood and Marrow Transplant Research), National Marrow Donor Program/Be The Match, Minneapolis, MN
¹⁰Division of Hematology and Oncology, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY
¹¹Sylvester Comprehensive Cancer Center, Miller School of Medicine, Miami, FL
¹²Division of Hematology, The Ohio State University Wexner Medical Center, Columbus, OH
¹³Division of Hematology, Mayo Clinic, Rochester, MN
¹⁴Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX
¹⁵Medical College of Wisconsin, Milwaukee, WI
¹⁶National Marrow Donor Program, Minneapolis, MN
¹⁷Myeloid Malignancies Program, National Institutes of Health, Bethesda, MD

Niccolò Bartalucci, PhD, BSc^1*, Francesco Mannelli, MD^2*, Simone Romagnoli^1*, Danilo Tarantino^1*, Barbara Scappini^3*, Alessio Enderti^1*, Giacomo Gianfaldoni^3*, Fiorenza Irushani^1*, Matteo Piccini^3*, Silvia Salmoiraghi^4*, Tiziana Ottone^5*, Alfonso Piciocchi, MS^6*, Silvia Orsi^7*, Marco Vignetti, MD^8*, Alessia Civini^9*, Chiara Pavoni^10*, Renato Bassan^11*, Stefania Bortoluzzi^7*, Adriano Venditti, MD¹², Alessandro Rambaldi, M.D.¹³, Maria Teresa Voso, MD¹⁴, Paola Guglielmelli, MD, PhD¹⁵ and Alessandro Maria Vannucchi¹

¹Department of Experimental and Clinical Medicine, Centro di Ricerca e Innovazione Malattie Mieloproliferative (CRIMM), AOU Careggi, University of Florence, Florence, Italy
²CRIMM, Center for Research and Innovation of Myeloproliferative Neoplasms, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy
³Hematology Unit, AOU Careggi, Florence, Italy
⁴Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII, Bergamo, Italy, Bergamo, Italy
⁵Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy
⁶Data Center and Health Outcomes Research Unit, GIMEMA Foundation, Rome, Italy
⁷Department of Molecular Medicine, University of Padova, Padova, Italy
⁸GIMEMA Foundation, Rome, Italy
⁹Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII, Bergamo, Italy
¹⁰Department of Oncology-Hematology, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy
¹¹Hematology Unit, Dell'Angelo Hospital, Mestre-Venezia, Italy
¹²Department of Onco-Hematology, Fondazione Policlinico Tor Vergata, Rome, Italy, Italy
¹³Hematology and Bone Marrow Transplant Unit, Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy
¹⁴Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
¹⁵CRIMM, Center of Research and Innovation of Myeloproliferative Neoplasms, University of Florence, AOU Careggi, Florence, Italy

Logan K Wallace^1*, Jack H Peplinski, BS^1*, Rhonda E Ries, MA^1*, Benjamin J Huang, MD², Xiaotu Ma, PhD³, Scott N Furlan, MD^4,5*, Danielle C Kirkey, MD^4,6 and Soheil Meshinchi, MD, PhD^5,7

¹Translational Sciences and Therapeutics, Fred Hutchinson Cancer Center, Seattle, WA
²Department of Pediatrics, University of California, San Francisco, San Francisco, CA
³St. Jude Children's Research Hospital, Memphis, TN
⁴Translational Science and Therapeutics, Fred Hutchinson Cancer Center, Seattle, WA
⁵Department of Pediatrics, University of Washington, Seattle, WA
⁶Division of Pediatric Hematology/Oncology, Seattle Children's Hospital, Seattle, WA
⁷Translational Sciences and Therapeutics, Fred Hutchinson Cancer Research Center, Seattle, WA

Aonkon Dey^1,2,3*, Rupa Narayan, MD^4,5, Neal Smith^1,2,3*, Alice Tirard^1,2,3*, Benjamin Arnold^1,2,3*, John McGuire^1,2,3*, Thomas Chan^1,2,3*, Jennifer Lombardi Story^6*, Timothy Casson^6*, Tanya Toni Behnan, BS^6*, Amir T. Fathi, MD^4,5, Gabriela S. Hobbs, MD^4,5, Hanno Hock, MD, PhD^4,5, Philip C. Amrein, MD^4,5, Patrick Reeves^4,7*, Timothy Aaron Graubert, MD^4,5, Andrew M. Brunner, MD^4,8 and Alexandra-Chloé Villani^1,2,3,4*

¹Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA
²Center for Cancer Research, Massachusetts General Hospital, Boston, MA
³Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA
⁴Harvard Medical School, Boston, MA
⁵Division of Hematology/Oncology, Massachusetts General Hospital, Boston, MA
⁶Mass General Cancer Center, Massachusetts General Hospital, Boston, MA
⁷Vaccine and Immunotherapy Center, Massachusetts General Hospital, Boston, MA
⁸Division of Hematology/Oncology, Dana-Farber Cancer Institute, Boston, MA

Lacey Scott Williams, MD¹, Alexis K Williams, MD^2*, Sarah Elizabeth Mudra, MD^3*, Paul Sackstein, MD^3*, Garrett Diltz, MD⁴, Rachel Zemel, MD^3*, Purnima Sravanti Teegavarapu, MD⁵, Martha P. Mims, MD, PhD⁶, Kimberley Doucette, MD³, Catherine Lai, MD⁷ and Gustavo A. Rivero, MD^3*

¹Lombardi Comprehensive Cancer Center, MedStar Georgetown University Hospital, Alexandria, VA
²NYU, New York CIty, NY
³Lombardi Comprehensive Cancer Center, MedStar Georgetown University Hospital, Washington, DC
⁴Lombardi Comprehensive Cancer Center, MedStar Georgetown University Hospital, Boston, MA
⁵Baylor College of Medicine, Houston, TX
⁶Section of Hematology-Oncology, Department of Medicine, Baylor College of Medicine, Houston, TX
⁷Abramson Cancer Center, Georgetown University Hospital, Washington, DC

Vikram Dhillon, DO, MBA^1,2, Jeff Aguilar, MD, MBA³, Sushmitha Nanja Reddy, MD, MBBS⁴, Lakshmi Bhavani Potluri, MD⁵, Jaroslaw P. Maciejewski, M.D., Ph.D., FACP⁶ and Suresh Kumar Balasubramanian, MD^4,6

¹Department of Hematology/Oncology, Neal Cancer Center/Houston Methodist Hospital, Detroit, MI
²Department of Oncology, Karmanos Cancer Center/Wayne State University, Detroit, MI
³Department of Oncology, Karmanos Cancer Institute/Wayne State University, Windsor, ON, Canada
⁴Karmanos Cancer Institute/Department of Oncology, Wayne State University, Detroit, MI
⁵Wayne State University/Sinai-Grace Hospital, Farmington Hills, MI
⁶Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH

Raphaël Liévin^1,2*, Nicolas Duployez, PharmD, PhD^3*, Loïc Vasseur^4*, Juliette Lambert^5*, Mael Heiblig^6*, Mathilde Hunault, MD, PhD^7*, Claude Gardin, MD, PhD^8*, Stephane De Botton, MD, PhD^9*, Elise Fournier^10*, Cecile Pautas^11*, Christine Terré^12*, Eric Delabesse, MD, PhD^13*, Norbert Ifrah, MD, PhD⁷, Arnaud Pigneux, MD, PhD^14*, Celli-Lebras Karine^15*, Christian Recher, MD, PhD^16*, Claude Preudhomme, PharmD, PhD^17*, Herve Dombret^18* and Raphael Itzykson^19,20

¹Laboratory of molecular mechanisms of hematological disorders and therapeutic implications, INSERM U 1163, Paris, France
²Hématologie Adulte - Maladies du sang, Hôpital Saint-Louis, AP-HP, Paris, France
³Laboratory of Hematology, Centre Hospitalier Universitaire (CHU) Lille, Lille, France
⁴Biostatistics and Medical Information Department, Saint Louis University Hospital, AP-HP, Université Paris Cité, Paris, France
⁵CH Andre Mignot, Le Chesnay Cedex, FRA
⁶Hematology Department, Centre Hospitalier Lyon Sud, Pierre-Bénite, France
⁷Hematology Department, CHU Angers, Angers, France
⁸Hôpital Avicenne, Hematology Department, AP-HP, Bobigny, France
⁹Department of Hematology, Institut Gustave Roussy, Villejuif, France
¹⁰University Hospital, Lille, LILLE, FRA
¹¹CHU Henri MONDOR, Creteil, FRA
¹²Laboratoire de Cytogénétique, Centre hospitalier de Versailles, Chesnay-Roquencourt, France
¹³IUCT-Oncopole, Hematology Laboratory, CHU de Toulouse - Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France
¹⁴Hématologie Clinique et Thérapie cellulaire, CHU Bordeaux, Bordeaux, France
¹⁵Hopital Saint-Louis, Paris, FRA
¹⁶IUCT-Oncopole, Hematology Department, CHU Toulouse, Toulouse, France
¹⁷Hematology Laboratory, CHU Lille, Lille, France
¹⁸Hopital Saint-Louis, Assistance Publique - Hopitaux De Paris (AP-HP), Paris, FRA
¹⁹Hematology Department, St Louis Hospital, Paris, France
²⁰INSERM U944, Paris, France

Chieh-Lin Jerry Teng, PhD^1*, Chung-Hsing Chen^2*, Tzu‐Hung Hsiao^3*, Ting-Shuan Wu^3* and Yu-Min Liao, MD⁴

¹Taichung Veterans General Hospital, Taichung, None, TWN
²National Institute of Cancer Research, National Health Research Institutes, Taiwan, Zhunan, Taiwan
³Taichung Veterans General Hospital, Taichung, Taiwan
⁴China Medical Univ. Hosp. Dept. of Medicine, Taichung, Taichung (city), TWN

Deepika Dilip, MPH^1*, Pallavi Galera, MBBS², David Nemirovsky, MS^3*, Morgan Lallo, BS^4*, Kamal Menghrajani, MD⁵, Andriy Derkach, PhD^3*, Ross L Levine, MD^6,7, Richard Koche, PhD^4*, Wenbin Xiao, MD, PhD⁸ and Jacob Glass, MD, PhD⁹

¹New York Medical College, Valhalla, NY
²Department of Pathology and Laboratory Medicine, Hematopathology Service, Memorial Sloan Kettering Cancer Center, New York
³Department of Biostatistics and Epidemiology, Memorial Sloan Kettering Cancer Center, New York, NY
⁴Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY
⁵MSKCC Memorial Sloan Kettering Cancer Center, New York, NY
⁶Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
⁷Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY
⁸Department of Pathology and Laboratory Medicine, Hematopathology Service, Memorial Sloan Kettering Cancer Center, New York, NY
⁹Leukemia Service, Department of Medicine, Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY

Laura W Dillon, PhD^1*, Gege Gui, ScM¹, Niveditha Ravindra, MD^1*, Georgia Andrew, BSc^1*, Devdeep Mukherjee, PhD^1*, Zoe Wong, BS^1*, Ying Huang, PhD^2*, Jason Gerhold^2*, Matthew Holman, BSc^2*, Jeffrey E Miller, PhD^2*, Jeffery J. Auletta, MD^3,4, Firas El Chaer, MD⁵, Steven M. Devine, MD³, Antonio M. Jimenez Jimenez, MD, MSc^6*, Marcos de Lima, MD^7*, Mark R. Litzow, MD⁸, Partow Kebriaei, MD⁹, Wael Saber, MD, MS^10,11*, Stephen R. Spellman, MBS^3,11*, Kristin M. Page, MD^3,10 and Christopher S. Hourigan, DM, DPhil^1,12

¹Laboratory of Myeloid Malignancies, Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, MD
²Invivoscribe, Inc., San Diego, CA
³Center for International Blood and Marrow Transplant Research, Minneapolis, MN
⁴Hematology/Oncology/Bone Marrow Transplant and Infectious Diseases, Nationwide Children's Hospital, Columbus, OH
⁵Department of Medicine, Division of Hematology and Oncology, University of Virginia Comprehensive Cancer Center, Charlottesville, VA
⁶Sylvester Comprehensive Cancer Center, Miller School of Medicine, Miami, FL
⁷Division of Hematology, The Ohio State University Wexner Medical Center, Columbus, OH
⁸Division of Hematology, Mayo Clinic, Rochester, MN
⁹Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX
¹⁰Medical College of Wisconsin, Milwaukee, WI
¹¹National Marrow Donor Program, Minneapolis, MN
¹²Myeloid Malignancies Program, National Institutes of Health, Bethesda, MD

Yaseswini Neelamraju¹, Franck Rapaport, PhD^2*, Jorge A Gandara^3*, Nicholas Dunham^4*, Hao Fan^5*, Tak Lee^6*, Subhash Prajapati^5*, Caroline Sheridan^6*, Ling Wang, BS^7*, Larry D. Cripe, MD⁸, Richard Dillon, PhD, MRCP, FRCPath^9*, Maria Kleppe, PhD, RPh^10*, Ross L Levine, MD¹¹, Christopher Mason^6*, Ari M Melnick, MD¹², Elisabeth Paietta, PhD^13*, Gail J. Roboz, MD¹⁴, Zhuoxin Sun, PhD^15*, Martin S. Tallman, MD¹⁶, Yanming Zhang, M.D.¹⁷, Stefan Bekiranov, PhD^4* and Francine E. Garrett-Bakelman, MD, PhD¹⁸

¹University of Virginia, Charlottesville, GA
²Memorial Sloan Kettering Cancer Center, New York, NY
³Weill Cornell Medicine, New York
⁴University of Virginia, Charlottesville, VA
⁵University of Virginia, Charlottesville
⁶Weill Cornell Medicine, New York, NY
⁷Weill Cornell Medical College, New York, NY
⁸Indiana University Simon Cancer Center, Indianapolis, IN
⁹Department of Medical and Molecular Genetics, King's College London, London, United Kingdom
¹⁰Memorial Sloan Kettering Cancer Center, New York
¹¹Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
¹²Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY
¹³Montefiore Medical Ctr. North Div, Bronx, NY
¹⁴New York Presbyterian Hospital, New York
¹⁵Dana-Farber Cancer Institute, Boston, MA
¹⁶Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Highland Park, IL
¹⁷Department of Pathology and Laboratory Medicine, Hematopathology Service, Memorial Sloan Kettering Cancer, New York, NY
¹⁸University of Virginia School of Medicine, Charlottesville, VA

Marketa Zaliova, MD, PhD^1,2*, Jan Zuna, MD, PhD^1,3, Lucie Winkowska, PhD^1,4*, Iveta Janotova^3*, Justina Skorepova, MD^1,3*, Julius Lukes, MD, PhD^1,3*, Claus Meyer, PhD^5*, Rolf Marschalek, PhD^5*, Jiri Domansky, MD^6*, Zbynek Novak, MD^7*, Jan Stary, MD, DSc^8*, Lucie Sramkova, MD, PhD^3* and Jan Trka, MD, PhD^1,3

¹Childhood Leukaemia Investigation Prague (CLIP), Prague, Czech Republic
²CLIP, Department of Pediatric Hematology and Oncology, University Hospital Motol, Prague, Czech Republic
³Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University/University Hospital Motol, Prague, Czech Republic
⁴CLIP, Department of Pediatric Hematology and Oncology, Second Faculty of Medicine, Charles University/University Hospital Motol, Prague, Czech Republic
⁵Institute of Pharmaceutical Biology/Diagnostic Center of Acute Leukemia, Goethe-University, Frankfurt, Germany
⁶Pediatric Oncology Department, University Hospital and Faculty of Medicine, Masaryk University, Brno, CZE
⁷Pediatric Department, University Hospital and Faculty of Medicine, Palacky University, Olomouc, Czech Republic
⁸Department of Pediatric Hematology and Oncology, Second Faculty of Medicine, Charles University/University Hospital Motol, Prague, Czech Republic

June Takeda, MD^1,2*, Makoto Iwasaki, MD, PhD^3*, Junya Kanda, MD, PhD^4*, Yasuhito Nannya, MD, PhD^2,5, Nobuhiro Hiramoto, MD^6*, Tadakazu Kondo, MD⁶, Takayuki Ishikawa, MD⁷, Mitsumasa Watanabe, MD, PhD⁸, Takahito Kawata, MD, PhD^8*, Takeshi Maeda, MD, PhD^9*, Yasunori Ueda, MD, PhD¹⁰, Kazunori Imada^11*, Toshiyuki Kitano, MD, PhD^12*, Masaaki Tsuji^13*, Yoshitomo Maesako^14*, Satoko Oka^15*, Yasuhiro Tanaka^16*, Takashi Miyoshi^17*, Kosuke Asagoe^18*, Mitsuru Itoh, MD, PhD¹⁹, Hirokazu Hirata, MD, PhD^20*, Hiroshi Kawabata, MD, PhD²¹, Masakatsu Hishizawa, MD^22*, Akinori Maeda^23*, Kazuhiro Yago, MD^24*, Nana Sasaki^25*, Nobuhiko Uoshima, MD, PhD^25*, Seishi Ogawa^26,27,28 and Akifumi Takaori-Kondo, MD, PhD¹

¹Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
²Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
³Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Nara, NAR, Japan
⁴Department of Hematology / Oncology, Kyoto University Graduate School of Medicine, Kyoto, Japan
⁵Division of Hematopoietic Disease Control, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
⁶Department of Hematology, Kobe City Hospital Organization Kobe City Medical Center General Hospital, Kobe, Japan
⁷Department of Hematology, Kobe City Medical Center General Hospital, Kobe, Hyogo, Japan
⁸Department of Hematology, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan
⁹Kurashiki Central Hospital, Kurashiki, Japan
¹⁰Department of Hematology/Oncology, Transfusion and Hemapheresis Center, Kurashiki Central Hospital, Kurashiki, Japan
¹¹Osaka Red Cross Hospital, Osaka, Japan
¹²Deptartment of Hematology., Kitano Hospital, Tazuke Kofukai Medical Research Institute, Kitano Hospital, Osaka, Japan
¹³Japan Red Cross Otsu Hospital, Otsu, Japan
¹⁴Department of Hematology, Takatsuki Red Cross Hospital, Osaka, Japan
¹⁵Department of Hematology, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan
¹⁶Department of Hematology, Shinko Hospital, Hyogo, Japan
¹⁷Uji Tokushukai Medical Center, Uji, Japan
¹⁸Shiga General Hospital, Moriyama, Japan
¹⁹Department of Hematology, Kyoto City Hospital, Kyoto, Japan
²⁰Department of Hematology, Kansai Electric Power Hospital, Osaka, Japan
²¹Department of Hematology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
²²Department of Hematology, Kyoto-Katsura Hospital, Kyoto, Japan
²³Department of Hematology, Shizuoka City Shizuoka Hospital, Shizuoka, Japan
²⁴Department of Hematology, Shizuoka General Hospital, Shizuoka, Japan
²⁵Department of Hematology, Red Cross Kyoto Daini Hospital, Kyoto, Japan
²⁶Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan
²⁷Department of Pathology and Tumor Biology, Kyoto University Graduate School of Medicine, Sakyoku, KYO, Japan
²⁸Center for Hematology and Regenerative Medicine, Department of Medicine (MedH), Karolinska Institutet, Huddinge, Sweden

Habib Hamidi, MPH, PhD^1*, Diana Dunshee^1*, Brian Higgins^2*, Monique Dail^3* and Michael Boyiadzis, MD³

¹Genentech, Inc., South San Francisco, CA
²Roche Innovation Center, New York, NY
³Genentech, South San Francisco, CA

Henri C. C. Hupe^1*, Clara P. Wienecke^1*, Stephan Bartels^2*, Elisa Schipper^2*, Jannika Leßmann^1*, Alina Lasch^1*, Maximilian Bader, MS^1*, Razif Gabdoulline^1*, Martin Wichmann^1*, Wolfram Puppe^3*, Michael Stadler^1*, Matthias Eder^1*, Arnold Ganser¹, Felicitas Thol¹ and Michael Heuser, MD¹

¹Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
²Department of Pathology, Hannover Medical School, Hannover, Germany
³Department of Virology, Hannover Medical School, Hannover, Germany

Kefei Wu, MD^1*, Hui Liu, MD^1*, Yangyang Xie, MD, PhD^1*, Yuhan Liu, MD^2*, Bowen Cui, Master^3*, Jiaoyang Cai, PhD⁴, Ronghua Wang, Master^3*, Yong Wang^5*, Xiang Wang, PhD^1*, Xiaoxiao Chen, MD^1*, Shuang Zhao^3*, Ting Liu, MD^1*, Han Wang, PhD^3*, Wenyan Wu, MD^3*, Huiying Sun, Master^3*, Jian'an Rao, Master^3*, Lan Wang, PhD^5*, Jing Chen, DO^1*, Jing Chen, MD, PhD^1*, Benshang Li, MD, PhD^1*, Yu Liu, PhD^1*, Wenting Hu, MD^1* and Shuhong Shen, MD, PhD¹

¹Key Laboratory of Pediatric Hematology & Oncology of the Ministry of Health of China, Department of Hematology & Oncology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
²Department of Respiratory Medicine, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
³Pediatric Translational Medicine Institute, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
⁴Key Laboratory of Pediatric Hematology & Oncology of the Ministry of Health of China, Department of Hematology & Oncology, Shanghai Children's Medical Center, Shanghai, China
⁵CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Shanghai Jiao Tong University School of Medicine (SJTUSM) & Chinese Academy of Sciences, Shanghai, China

Uma M. Borate, MD¹, Ying Huang, MS, MA², Rina Li Welkie, MPH³, Ronan T. Swords, MD, PhD, FRCP, FRCPath⁴, Elie Traer, MD, PhD⁵, Eytan M. Stein⁶, Tara L Lin, MD⁷, Yazan F. Madanat, MD⁸, Prapti A. Patel, MD⁹, Robert H. Collins, MD⁸, Maria R. Baer, MD¹⁰, Vu H. Duong, MD, MS¹⁰, William Blum, MD¹¹, Martha Arellano¹², Wendy Stock, MD¹³, Olatoyosi Odenike¹⁴, Robert L. Redner, MD¹⁵, Tibor J. Kovacsovics, MD¹⁶, Michael W. Deininger, MD, PhD^17,18, Joshua F. Zeidner, MD¹⁹, Rebecca Olin, MD²⁰, Catherine C. Smith, MD²¹, James M. Foran, MD²², Gary J. Schiller, MD²³, Emily K Curran, MD²⁴, Kristin L Koenig, MD²⁵, Nyla A. Heerema, PhD^26*, Timothy Chen, PhD^27*, Molly Martycz^27*, Mona Stefanos, MD²⁷, Sonja Gullen Marcus, MPH^28*, Leonard Rosenberg^28*, Brian J. Druker, MD²⁹, Ross L Levine, MD³⁰, Amy Burd, PhD³¹, Ashley Owen Yocum, PhD²⁸, Alice Mims, MD³² and John C. Byrd, MD³³

¹Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH
²Division of Hematology, The Ohio State University, Columbus, OH
³The James Cancer Center, The Ohio State University Wexner Medical Center, Columbus, OH
⁴Knight Cancer Institute, Oregon Health and Science University, Portland, OR
⁵Knight Cancer Institute, Oregon Health & Sciences University, Portland, OR
⁶Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY
⁷Division of Hematologic Malignancies and Cellular Therapeutics, The University of Kansas Medical Center, Westwood, KS
⁸Hematologic Malignancies and Cellular Therapy, University of Texas Southwestern Medical Center, Dallas, TX
⁹University of Texas Southwestern Medical Center, Westlake, TX
¹⁰Department of Medicine, University of Maryland School of Medicine, Baltimore, MD
¹¹Winship Cancer Institute of Emory University, Atlanta, GA
¹²Emory University School of Medicine, Atlanta, GA
¹³University of Chicago Medicine, Chicago, IL
¹⁴The University of Chicago Medicine and Comprehensive Cancer Center, Chicago, IL
¹⁵University of Pittsburgh Medical Center, Pittsburgh, PA
¹⁶University of Utah, Salt Lake City, OR
¹⁷Division of Hematology and Hematologic Malignancies, University of Wisconsin Milwaukee, Milwaukee, WI
¹⁸Deininger Lab, Versiti Blood Research Institute, Milwaukee, WI
¹⁹University of North Carolina, Lineberger Comprehensive Cancer Center, Chapel Hill, NC
²⁰University of California San Francisco, San Francisco, CA
²¹Department of Medicine, Division of Hematology/Oncology, University of California San Francisco, San Francisco, CA
²²Hematology/Oncology, Mayo Clinic, Jacksonville, FL
²³Hematological Malignancy/ Stem Cell Transplant Program, David Geffen School of Medicine, UCLA, Los Angeles, CA
²⁴University of Cincinnati, Cincinnati, OH
²⁵Division of Hematology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH
²⁶Ohio State University, Columbus, OH
²⁷The Ohio State University, Columbus, OH
²⁸Leukemia and Lymphoma Society, Rye Brook, NY
²⁹Oregon Health & Science University, Portland, OR
³⁰Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
³¹Leukemia and Lymphoma Society, White Plains, NY
³²Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH
³³Department of Internal Medicine, University of Cincinnati, Cincinnati, OH

Shyam Ajay Patel, MD, PhD^1*, Salwa Khedr, MD^2*, Sri Nuvvula^2*, Bruce Woda, MD², Jan Cerny, MD, PhD², William Selove^3*, Lloyd Hutchinson^2* and Jonathan M. Gerber, MD²

¹Department of Medicine - Division of Hematology/Oncology, UMass Chan Medical School, Shrewsbury, MA
²UMass Chan Medical School, Worcester, MA
³UMass Memorial Medical Center, Whitinsville, MA

Vanessa E. Kennedy, MD^1,2, Cheryl A C Peretz, MD^2,3, Andrew Koh^3*, Elaine Tran^4*, Dalia Dhingra^5*, Saurabh Gulati^5*, Adam Sciambi, PhD^5*, Olga Sala-Torra, MD^6*, Lan Beppu^6*, Aaron C. Logan, MD, PhD⁷, Alexander Perl⁸, Wendy Stock, MD⁹, Geoffrey L Uy, MD¹⁰, Ann-Kathrin Eisfeld, MD*¹¹, Jerald P. Radich, MD¹² and Catherine C. Smith, MD¹

¹Department of Medicine, Division of Hematology/Oncology, University of California San Francisco, San Francisco, CA
²equal contribution, #
³UCSF, San Francisco, CA
⁴UCSF, San Francisco
⁵Mission Bio Inc, South San Francisco
⁶Fred Hutchinson Cancer Center, Seattle, WA
⁷Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA
⁸Division of Hematology/Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA
⁹Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL
¹⁰Division of Oncology, Washington University School of Medicine, Saint Louis, MO
¹¹Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University, Columbus, OH
¹²Translational Sciences & Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA

Suning Chen^1*, Lijun Wen, MD^1*, Lijuan Gao^1*, Yayun Du^2*, Yi Xu^1*, Qian Wu^1*, Xiaofei Yang^1*, Jinlan Pan^1*, Mingqing Zhu^1*, Dandan Liu^1*, Jiannong Cen^1*, Hongjie Shen^1*, Zhao Zeng^1*, Jingren Zhang^1*, Haohao Lu^2*, Zhibo Zhang^1*, Yusha Guo^1*, Zheng Wang^3*, Tingting Zhang^1*, Xiebing Bao^1*, Qian Wang^1*, Qinrong Wang^1*, Yang Xu^1*, Jianhong Fu^1*, Huiying Qiu^1*, Xiaowen Tang^1*, Yue Han^4*, Miao Miao^1*, Shengli Xue^5*, Ying Wang^1*, Sudan He^2* and Depei Wu¹

¹National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China
²Center of Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medial College Suzhou Institute of Systems Medicine, Suzhou, China
³National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou jsuniwell medical laboratory, Suzhou, China
⁴National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China
⁵Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China

Luca Guarnera, MD^1,2*, Carmelo Gurnari, MD^1,2, Carlos Bravo-Perez, MD^1,3*, Arda Durmaz^1*, Nakisha D Williams, MBBS^1*, Hussein Awada^1*, Naomi Kawashima, MD, PhD^1*, Arooj Ahmed, MD^1*, Serhan Unlu, MD^1*, Christopher Haddad^1*, Aashray Mandala, BS^1*, Yasuo Kubota, MD, PhD^4*, Jaroslaw P. Maciejewski, M.D., Ph.D., FACP¹ and Valeria Visconte, PhD¹

¹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
²Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
³Department of Hematology and Medical Oncology, Hospital Universitario Morales Meseguer, University of Murcia, IMIB-Pascual Parrilla, CIBERER - Instituto de Salud Carlos III, Murcia, Spain
⁴Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Beachwood, OH

Matthew Markham, PhD^1*, David Riley, PhD^1*, Rebecca S Maynard, MSc^2*, Katherine Hampton, MSc, BSc^1*, Ravindu De Silva^1,3*, Charlotte Hellmich, PhD, BSc, MBBChir^1,3, Kristian Bowles, MBBS, PhD^1,3 and Stuart Rushworth, PhD¹

¹Norwich Medical School, University of East Anglia, Norwich, United Kingdom
²Norwich Medical School, University of East Anglia, Norwich, ENG, United Kingdom
³Norfolk and Norwich University Hospital, Norwich, United Kingdom

Pilgrim Jackson^1*, Derek Stirewalt, MD², James Sorrentino, Ph.D.^3*, Salvador Martinez de Bartolome Izquierdo, Ph.D.^3*, Mahan Abbasian, M.S.^3*, Robert Bates, M.S.^3* and Jasmine Naru^4*

¹Yatiri Bio Inc., San Diego, CA
²Fred Hutchinson Cancer Rsch. Ctr., Seattle, WA
³Yatiri Bio, San Diego, CA
⁴Fred Hutchinson Cancer Research center, Seattle, WA

Jansen N Seheult, M.D.^*, Min Shi, MD^*, Horatiu Olteanu, M.D., Ph.D., Gregory E Otteson^*, Michael M Timm^*, Matthew J Weybright^* and Pedro Horna, MD

Division of Hematopathology, Mayo Clinic, Rochester, MN