Yuxuan Liu, PhD¹, Haowen Jiang, PhD^2*, Lucille Stuani, PhD^3,4*, Jolanda Sarno, PhD⁵, Pablo Domizi, PhD¹, Milton Merchant^1*, Dorra Jedoui^4*, Astraea Jager^1*, Min Huang, MD, PhD^4*, Norman J. Lacayo, MD^4*, Kathleen M. Sakamoto, MD, PhD⁶, Jiangbin Ye, PhD^2* and Kara L. Davis, DO⁴

¹Department of Pediatrics, Hematology, Oncology, and Stem Cell Transplant and Regenerative Medicine, Stanford University, Stanford, CA
²Department of Radiation Oncology, Stanford University School of Medicine, Stanford
³Univ. Montpellier, Institut régional du Cancer de Montpellier (ICM), Institut de Recherche en Cancérologie de Montpellier (IRCM), INSERM, Montpellier, France
⁴Bass Center for Childhood Cancer and Blood Disorders, Department of Pediatrics, Stanford University, Stanford, CA
⁵Department of Pediatrics, Hematology, Oncology, and Stem Cell Transplant and Regenerative Medicine, Stanford University, Palo Alto, CA
⁶Department of Pediatrics, Stanford University, Stanford, CA

Cristina Borin^1*, Tim Pieters, PhD^2,3,4*, Pieter Van Vlierberghe, PhD^2,3,4* and Panagiotis Ntziachristos, PhD^1,5

¹Ghent University, Ghent, Belgium
²Center for Medical Genetics Ghent (CMGG), Ghent University, Ghent, Belgium
³Department of Biomolecular Medicine, Ghent University, Ghent, Belgium
⁴Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium
⁵Ghent University, Corneel Heymanslaan 10, Ghent, Belgium

Jae-Ho Yoon, MD¹, Daehun Kwag^2*, Gi June Min, MD¹, Sung-Soo Park^3*, Silvia Park^4*, Sung-Eun Lee, MD^5*, Byung-Sik Cho^1*, Ki-Seong Eom^1*, Yoo-Jin Kim¹, Hee-Je Kim¹, Chang-Ki Min^1*, Seok-Goo Cho^1*, Jong-Wook Lee, MD⁶ and Seok Lee¹

¹Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)
²Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, Th, Seoul, South Korea
³Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea
⁴Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, AL, South Korea
⁵Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Houston, TX
⁶Department of Hematology, Seoul St. Mary's Hospital Catholic University of Korea, Seoul, South Korea

Yan Huang^1*, Luting Luo^1,2*, Yanxin Chen^1*, Zhengjun Wu^1*, Jiazheng Li^1,2*, Yangqi Xu^1*, Lingyan Wang^1*, Haojie Zhu^3*, Ting Yang, MD, PhD^4* and Jianda Hu, PhD^1,2

¹Fujian Institute of Hematology, Fujian Provincial Key Laboratory of Hematology, Fujian Medical University Union Hospital, Fuzhou, China
²Department of Hematology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
³Department of Hematology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China
⁴Department of Hematology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China

Giacomo Gotti, MD^1*, Daniela Silvestri^2*, Grazia Fazio, PhD^2*, Chiara Palmi, PhD^2*, Valentino Conter, MD^2*, Maria Grazia Valsecchi, PhD^3,4*, Carmelo Rizzari, MD^1,3*, Barbara Buldini, MD, PhD⁵, Franco Locatelli, MD, PhD⁶, Andrea Biondi, MD^1,3 and Giovanni Cazzaniga, PhD^2,3

¹Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy
²Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy
³School of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy
⁴Biostatistics and Clinical Epidemiology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy
⁵Department of Pediatric Hematology and Oncology, University of Padova, Padua, Italy
⁶Department of Pediatric Hematology/Oncology, Cell and Gene Therapy, IRCCS Bambino Gesù Children’s Hospital, Catholic University of the Sacred Heart, Rome, Italy

Signe Modvig, MD, PhD^1,2*, Hanna Thorsson, PhD^3*, Bodil Als-Nielsen, MD^4*, Claus Christensen, PhD^2*, Nina Friesgaard Øbro, PhD^2*, Hans O. Madsen, Msc^5*, Henrik Lilljebjörn, PhD^6*, Kjeld Schmiegelow, MD, DMsc^7,8*, Thoas Fioretos, MD, PhD⁹ and Hanne Vibeke Marquart, MD, PhD^1,2*

¹Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark
²Department of Clinical Immunology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
³Division of Clinical Genetics, Lund University, Lund, Sweden
⁴Department of Pediatrcis and Adolescent Medicine, University Hospital Rigshospitalet, Copenhagen, DNK
⁵Department of Clinical Immunology, University Hospital Rigshospitalet, Copenhagen, Denmark
⁶Division of Clinical Genetics, Lund University, Lund, SWE
⁷Department of Pediatrics and Adolescent Medicine, Rigshospitalet University Hospital, Copenhagen, Denmark
⁸Medical Faculty, Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
⁹Department of Clinical Genetics, Lund University, Lund, Sweden

Sabina Enlund, MSc^1*, Christina Neofytou^1*, Indranil Sinha, PhD^1*, Amanda Ramilo Amor^1*, Anna B Nilsson, MD, PhD^1*, Qingfei Jiang, PhD², Ola Hermanson, PhD^1* and Frida Holm, PhD^1*

¹Karolinska Institutet, Solna, Sweden
²UCSD, La Jolla, CA

Cesca Van De Ven, PhD^1*, Mandy W.E. Smeets, MSc^1,2*, Elisabeth M.P. Steeghs, PhD^2* and Monique L. den Boer, PhD^1,2

¹Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
²Department of Pediatric Oncology/Hematology, Erasmus University Medical Center-Sophia Children’s Hospital, Rotterdam, Netherlands

Tong Wang, MD^1,2*, Jingbo Ni^3*, Xue Chen, MD^1*, Panxiang Cao, MS^1*, Jinan Tan^3*, Hongwei Zhang^3*, Jiangcheng Fang^1*, Xinying Wei^3*, Jiaqi Chen, PhD^3,4,5*, Xiaoli Ma, MD^1*, Yang Zhang, MD^6*, Fang Wang, MD^7*, Yan Zhang^3*, Yan Dai^3* and Hongxing Liu^2,3

¹Department of Laboratory Medicine, Hebei Yanda Lu Daopei Hospital, Langfang, China
²Beijing Lu Daopei Institute of Hematology, Beijing, China
³Hebei Yanda Lu Daopei Hospital, Langfang, China
⁴Department of Laboratory Medicine, Hebei Yanda Lu DaoPei Hospital, Langfang, China
⁵Molecular Medicine Center, Beijing Lu Daopei Institute of Hematology, Beijing, China
⁶Hebei Yanda Lu Daopei Hospital, Langfang, Hebei, China
⁷Pathology & Laboratory Medicine Division, Hebei Yanda Lu Daopei Hospital, Langfang, Hebei, China

Nicolas Boissel, MD, PhD^1*, Francoise Huguet, MD^2*, Thibaut Leguay^3*, Mathilde Hunault, MD, PhD^4*, Rathana KIM, Pharm.D.^5*, Yosr Hicheri^6*, Marie Passet, Pharm.D. / Ph.D.^7*, Patrice Chevallier, MD⁸, Marie Balsat, MD^9*, Sebastien Maury^10*, Anne Thiebaut, MD^11*, Florence Van Obbergh^12*, Thomas Cluzeau, MD, PhD¹³, Martine Escoffre Barbe, MD^14*, Nicole Straetmans¹⁵, Johanna Konopacki^16*, Amine Belhabri, MD^17*, Alban Villate, MD^18*, Florence Pasquier, MD, PhD^19*, Didier Bouscary^20*, Thorsten Braun, MD, PhD²¹, Sabine Blum^22*, Victoria Cacheux^23*, Caroline Bonmati, MD^24*, Sebastian Wittnebel^25*, Véronique Lhéritier^26*, Norbert Ifrah, MD, PhD⁴, Carlos Graux^27*, Yves Chalandon, MD²⁸, Emmanuelle Clappier, PhD, PharmD^29* and Herve Dombret, MD³⁰

¹Hôpital Saint-Louis, Paris, France
²IUCT-Oncopole, Toulouse, France
³Hopital Du Haut-Leveque, Pessac, FRA
⁴Hematology Department, CHU Angers, Angers, France
⁵Assistance Publique Des Hopitaux De Paris (AP-HP) - Universite Paris Descartes -, Paris, Ile-de-France, FRA
⁶Department of Hematology, Institut Paoli-Calmettes, Marseille, France
⁷APHP, Paris, FRA
⁸CHU de Nantes - Hôtel Dieu, Nantes, France
⁹Clinical Hematology Department, Hospices Civils de Lyon, Lyon Sud Hospital, Pierre-Bénite, France, Lyon, France
¹⁰Hematology Department, Hôpitaux universitaires Henri Mondor AP-HP & Université Paris Est Créteil, Créteil, France
¹¹service d'hématologie clinique, CHUGA Grenoble, Grenoble, France
¹²Centre Hospitalier de Jolimont, La Louviere, BEL
¹³CHU Nice, Nice, FRA
¹⁴Department of hematology, Rennes, France
¹⁵Cliniques St-Luc, Université Catholique de Louvain, Bruxelles, BEL
¹⁶HIA PERCY, CLAMART, FRA
¹⁷Centre Leon Berard, Lyon, FRA
¹⁸CHRU Bretonneau, Tours, FRA
¹⁹INSERM U790, PR1, IGR, Villejuif, FRA
²⁰APHP Cochin Hospital, Paris, FRA
²¹Clinical Hematology, Avicenne University Hospital, Assistance Publique – Hôpitaux de Paris, Bobigny, France
²²Lausanne University Hospital CHUV, Lausanne, CHE
²³CHU Estaing, Clermont Ferrand, FRA
²⁴Hematology Department, CHU Nancy, Nancy, France
²⁵Jules Bordet Institute, Université Libre de Bruxelles, Anderlecht, BEL
²⁶Service d’Hématologie Coordination GRAALL, HCL, Hôpital Lyon Sud, Pierre Bénite, France
²⁷Department of Hematology, Université catholique de Louvain, CHU UCL Namur - site Godinne, Yvoir, BEL
²⁸Univ. Hospital of Geneva, Geneva, CHE
²⁹Hôpital Saint-Louis, APHP, Paris, FRA
³⁰HôPital Saint-Louis, Assistance Publique - HôPitaux De Paris (AP-H, Paris, FRA

Fabio D. Steffen, PhD^1*, Andrej Lissat, MD^2*, Julia Alten^3*, Cornelia Eckert, PhD^2*, Nicole Bodmer, MD^1*, Bodil E. Thorhauge Als-Nielsen, MD^4*, Adriana Balduzzi, MD^5,6*, Barbara Buldini, MD, PhD⁷, Sarah Elitzur, MD⁸, Andras Kriston^9*, Gergely Nyiri^9*, Imre Västrik^10*, Ferenc Kovacs^9*, Francesco Ceppi, MD¹¹, Lucie Sramkova, MD, PhD^12*, Larissa Schori, Msc^1*, Arianna Arpagaus, Msc^1*, Silvia Gutnik, PhD^1*, Andishe Attarbaschi, Prof., MD^13*, Birgitte Klug Albertsen, MD^14*, Jeanette Greiner, MD^15*, Marc Ansari, MD, PhD¹⁶, Judith M. Boer, PhD¹⁷, Elad Jacoby, MD¹⁸, Martin Stanulla, MD^19*, Uri Ilan, MD^17*, Peter M. Hoogerbrugge, MD, PhD¹⁷, Tim Lammens, PhD, MSc^20*, Barbara De Moerloose, MD^21*, Petter Svenberg, MD^22*, Nicolas von der Weid, MD²³, David O'Connor, MD^24*, Hélène Cavé, PhD^25*, Franco Locatelli, MD, PhD²⁶, Martin Schrappe, MD²⁷, André Baruchel, MD, PhD²⁵, Andreas Kulozik, MD, PhD²⁸, Kjeld Schmiegelow, MD⁴, Gunnar Cario, MD^27*, Arend von Stackelberg, MD^29*, Peter Horvath^9,30*, Beat Bornhauser, PhD^1* and Jean-Pierre Bourquin, MD, PhD³¹

¹Department of Oncology, University Children's Hospital Zurich, Zurich, Switzerland
²Department of Hematology and Oncology, Charité Universitätsmedizin Berlin, Berlin, Germany
³Department of Pediatrics, Universitätsklinikum Schleswig-Holstein, Kiel, Germany
⁴Department of Pediatrics and Adolescent Medicine, Rigshospitalet, Copenhagen, Denmark
⁵Pediatric Hematopoietic Stem Cell Transplant Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy
⁶Department of Medicine and Surgery, Milano-Bicocca University, Milano, Italy
⁷Department of Pediatric Hematology and Oncology, University of Padova, Padua, Italy
⁸Schneider Children's Medical Center, Petah Tikva, Israel
⁹Single-cell Technologies, Szeged, Hungary
¹⁰Finnish Institute of Molecular Medicine, Helsinki, Finland
¹¹CHUV University Hospital, Lausanne, VD, Switzerland
¹²Department of Paediatrics Haematology and Oncology, University Hospital Motol, Prague, Czech Republic
¹³Department of Pediatric Hematology and Oncology, St. Anna Children's Hospital, Medical University Vienna, Vienna, Austria
¹⁴Aarhus University Hospital, Aarhus, Denmark
¹⁵Kantonsspital Aarau, Aarau, Switzerland
¹⁶Hôpital Universitaire de Genève, Switzerland, Geneve, Switzerland
¹⁷Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
¹⁸Department of Pediatric Hematology-Oncology, Safra Children's Hospital, Sheba Medical Center, Tel Aviv, Israel
¹⁹Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany
²⁰Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Oost-Vlaanderen, Belgium
²¹Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
²²Karolinska University Hospital, Stockholm, Sweden
²³Universitäts-Kinderspital beider Basel, Basel, Switzerland
²⁴Department of Haematology, Great Ormond Street Hospital for Children, London, United Kingdom
²⁵Hôpital Robert Debré, Paris, France
²⁶Department of Pediatrics, Catholic University of the Sacred Heart, Rome, Italy
²⁷Department of Pediatrics, University Hospital Schleswig-Holstein, Kiel, Germany
²⁸Department of Pediatric Oncology, Hematology, and Immunology and Hopp-Children’s Tumor Center, University of Heidelberg and DKFZ, Heidelberg, Germany
²⁹Department of Pediatric Oncology and Hematology, Charité Universitaetsmedizin Berlin, Berlin, Germany
³⁰Biological Research Centre, Szeged, Hungary
³¹Department of Oncology and Children’s Research Center, University Children's Hospital Zurich, Zurich, Switzerland

Stuart Adams^1*, Jeremy Hancock^2*, Joe Kaplinsky^3*, Alona Sosinsky^3*, Gary Wright^1*, Soragia Athina Gkazi^1*, Susanne Kricke^1*, Rebecca Thomas^1*, Natalie Kent^1*, Angus Hodder, MBBS^4* and Jack Bartram^4,5*

¹Haematology, Great Ormond Street Hospital for Children, London, United Kingdom
²Southmead Hospital, Bristol Genetics Laboratory, Bristol, United Kingdom
³Genomics England, London, United Kingdom
⁴Department of Haematology, Great Ormond Street Hospital for Children, London, United Kingdom
⁵North Thames Genomic Laboratory Hub, Londom, United Kingdom

Jesús Gutiérrez-Abril^1*, Gunes Gundem^2*, Elise Fiala^3*, Konstantinos Liosis^3*, Noushin Farnoud, PhD^3*, Daniel Leongamornlert, PhD^4*, Anu Amallraja^3*, Juan E. Arango Ossa^2*, Dylan Domenico^3*, Max F. Levine^5*, Juan Santiago Medina Martinez^5*, Michael F. Walsh, MD^3*, Sylwia Jasinski, MD^6*, Andrew L. Kung, MD, PhD³, Neerav N. Shukla⁷, William L. Carroll, MD⁸ and Elli Papaemmanuil³

¹Department of Epidemiology & Biostatistics, Universidad De Oviedo, Oviedo, Spain
²Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY
³Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY
⁴Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, United Kingdom
⁵Isabl Inc., New York, NY
⁶Department of Pediatrics, NYU Long Island School of Medicine, Mineola, NY
⁷Memorial Sloan Kettering Cancer Center, New York, NY
⁸Perlmutter Cancer Center, Department of Pediatrics and Pathology, NYU Grossman School of Medicine, New York, NY

Adrian Mosquera Orgueira, MD, PhD^1*, Olga Krali^2*, Andres Peleteiro Raindo^3*, Jose Angel Diaz Arias^4*, Marta Sonia Gonzalez Perez^5*, Manuel Perez Encinas^6*, Manuel Fernandez Sanmartin^7*, Natalia Alonso Vence^8*, Daniel Sinnett, PhD^9*, Mats Heyman¹⁰, Gudmar Lönnerholm^11*, Ulrika Norén-Nyström, MD, PhD^12*, Kjeld Schmiegelow¹³ and Jessica Nordlund^2*

¹University Hospital of Santiago de Compostela, Department of Hematology, IDIS, SANTIAGO DE COMPOSTELA, Spain
²Department of Medical Sciences and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
³University Hospital of Santiago De Compostela, Department of Hematology, IDIS, SANTIAGO DE COMPOSTELA, ESP
⁴University Hospital of Santiago de Compostela, Department of Hematology, IDIS, A Coruña, Spain
⁵University Hospital of Santiago de Compostela, Santiago de Compostela, Spain
⁶University Hospital of Santiago de Compostela, Department of Hematology, IDIS, SANTIAGO, ESP
⁷University Hospital of Santiago de Compostela, Department of Pediatrics, IDIS, Santiago de Compostela, Spain
⁸University Hospital of Santiago de Compostela, Department of Hematology, IDIS, Santiago de Compostela, Spain
⁹Hopital Ste.-Justine Centre de Cancerologie Charles Brunea, Montreal, QC, CAN
¹⁰Childhood Cancer Research Unit, Karolinska Institute, Stockholm, Sweden
¹¹Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden
¹²Department of Clinical Sciences, Pediatrics, Umeå University Hospital, Umeå, Sweden
¹³Copenhagen University, Copenhagen, DNK

Sonja Bendig^1,2*, Sandra Bufe, PhD^3*, Birgit Fricke^3*, Constantin Proske^3*, Nikos Darzentas, PhD^3*, Britta Kehden^3*, Guranda Chitadze^2,3*, Claudia D Baldus, MD^2,4*, Michaela Kotrova, MD, PhD^3*, Nicola Goekbuget, MD⁵ and Monika Brüggemann, MD^2,3*

¹University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany
²Clinical Research Unit CATCH ALL (KFO 5010/1) funded by the Deutsche Forschungsgemeinschaft, Kiel, Germany
³Medical Department II, Hematology/Oncology, University Hospital Schleswig-Holstein, Kiel, Kiel, Germany
⁴Department of Internal Medicine II (Hematology/Oncology), University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany
⁵Goethe University Hospital, Frankfurt, Germany

Jim Zhongning Chen, MD¹, Alan Baltz, MD^2*, Tyler Fugere, MD³, Emily Noel Sanders, MD^4*, Fnu Amisha, MD⁵, Cesar Giancarlo Gentille Sanchez, MD^3* and Maria Alejandra Pereda, MD^6*

¹Department of Hematology Oncology, UAMS, AR, AR
²UAMS, Little Rock, AR
³University of Arkansas for Medical Sciences, Little Rock, AR
⁴Arkansas Children's Hospital, Little Rock, AR
⁵H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL
⁶Center for Cancer and Blood Disorders, Children’s Hospital, University of Colorado, Aurora, CO

Abhijit Chakraborty, PhD^1*, Laura Hinojosa^2*, Vivek Chandra^1*, Benjamin Schmiedel, PhD^3*, Monalisa Mondal^4*, Nirmalya Dasgupta, PhD^1*, Pandurangan Vijayanand, MD, PhD^5*, Preethi Ganesan, MD, PhD^3* and Ferhat Ay^4*

¹La Jolla Institute for Immunology, La Jolla, CA
²La Jolla Institute For Immunology, La Jolla
³La Jolla Institute for Immunology, La Jolla
⁴LA JOLLA INSTITUTE FOR IMMUNOLOGY, La Jolla, CA
⁵La Jolla Institute For Immunology, La Jolla, CA