Guohui Ren, MD, PhD^1*, Jiwang Chen, PhD^2*, Richard Minshall, PhD^2*, Maricela Castellon, MS^3*, Maria Armila Ruiz, MS^4*, Victor R. Gordeuk, MD⁵ and Santosh L. Saraf, MD⁶

¹University of Illinois At Chicago, CHICAGO, IL
²University of Illinois at Chicago, Chicago, IL
³University of Illinois at Chicago, Chicago
⁴University of Illinois At Chicago, Chicago, IL
⁵Sickle Cell Center, University of Illinois at Chicago, Chicago, IL
⁶Department of Medicine, University of Illinois College of Medicine, Willowbrook, IL

Milica Vukotić, PhD^1*, Teodora Dragojević, MD^1*, Emilija Živković^1*, Miloš Diklić, PhD^1*, Olivera Mitrović Ajtić, PhD^1*, Constance T Noguchi, PhD^2*, Alan N Schechter, MD² and Vladan P Čokić, MD, PhD^1*

¹Institute for medical research, National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia
²Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD

Julien Grenier, PhD^1*, Barbara Peyrard^2*, Auria Godard^1*, Julien Cheyrol^3*, Thiago Trovati Maciel, PhD^4*, Wassim El Nemer, PhD¹ and Maria De Grandis, PhD^1*

¹EFS PACA-Corse, Aix Marseille University, UMR 7268 ADES, Marseille, France
²EFS-PACA corse UMR 7268 – Aix-Marseille University, Marseille, France
³Centre d’exploration fonctionnelle scientifique (CEFOS)- Aix-Marseille University, Marseille, France
⁴Institut IMAGINE - INSERM U1163, Paris, FRA

Matheus Ajeje Souza^1*, Izabela Felice Paes^1*, Sara Teresinha Olalla Saad, MD², Fernando Ferreira Costa, MD, PhD³ and Renata Sesti-Costa, PhD^4*

¹Institute of Biology, University of Campinas - UNICAMP, Campinas, Sao Paulo, Brazil
²Hematology and Transfusion Medicine Center - University of Campinas/Hemocentro-UNICAMP, Campinas, São Paulo, Brazil
³Hematology and Transfusion Center, University of Campinas - UNICAMP, Campinas, Sao Paulo, Brazil
⁴Hematology and Hemotherapy Center, University of Campinas - UNICAMP, Campinas, Brazil

Dario Vitturi, PhD^1*, Danielle Crosby, BS^2*, Shane C Lenhart, BS^2*, Mara Carreno, MS^3*, Diane Lenhart, MS^2* and Samit Ghosh, PhD²

¹University of Alabama at Birmingham, Birmingham
²Pittsburgh Heart Lung Blood Vascular Institute (VMI), Department of Medicine, University of Pittsburgh, Pittsburgh, PA
³University of Alabama at Birmingham, Birmingham, AL

Rudra Ray, PhD^1*, John Hamre^1*, Kang Le^1*, Xunde Wang, PhD^1*, Justin Lack^2*, Yuesheng Li^3*, Zenaide Quezado, MD^4,5 and Swee Lay Thein, MBBS, DSc, FRCP, FRCPath, MRCP, MRCPath⁶

¹Sickle Cell Branch, National Heart, Lung & Blood Institute, NIH, Bethesda, MD
²Bioinformatics (NCBR)/Integrated Data Sciences Section(IDSS)/ Research Technology Branch/DIR, NIAID, NIH, National Institutes of Health, Bethesda, MD
³DNA SEQUENCING & COMPUTATIONAL BIOLOGY CORE, NHLBI, NIH, National Institutes of Health, Bethesda, MD
⁴Department of Perioperative Medicine, NIH Clinical Center, Bethesda, MD
⁵Sickle Cell Branch, NHLBI, NIH, Bethesda, MD
⁶Sickle Cell Branch, National Heart, Lung & Blood Institute, Bethesda, MD

Frederic Truffinet^1*, Caroline Compain^2*, Maria Elena Manea^2*, Anoosha Habibi³, Elena Fois^2*, Etienne Audureau^4,5*, Sophie Hue^6*, Marc Michel^7* and Pablo Bartolucci^8*

¹CHU Henri Mondor. UPEC. AP-HP, Paris 12, France
²CHU Henri Mondor. UPEC. AP-HP, Creteil, France
³sickle cell referral center, APHP, Hôpital Henri Mondor, Creteil, France, Joinville le pontCréteil, France
⁴Henri Mondor APHP, Creteil, France
⁵Unité de Recherche Clinique, Henri-Mondor University Hospital- UPEC, AP-HP, Creteil, France
⁶CHU Henri Mondor. UPEC. AP-HP, creteil, France
⁷Internal medicine department, Henri Mondor Hospital, APHP, Créteil, France
⁸CHU Henri Mondor. UPEC. AP-HP, Créteil, France

Gonzalo De Luna, MD^1*, Anoosha Habibi, MD¹, Stephane Moutereau^2*, Suella Martino^1*, Yanis Pelinsky^1*, Yosr Zaouali^1*, Galacteros Frederic^1* and Pablo Bartolucci, MD, PhD^1*

¹Sickle Cell Referral Center, Henri-Mondor University Hospital- UPEC, AP-HP, Creteil, France
²Department of Biochemistry, Henri-Mondor University Hospital- UPEC, AP-HP, Creteil, France

Rawan Korman, MD¹, Dunia Hatabah, MD¹, Lou Ann Brown, PhD^2*, Frank Harris^2*, Nitya Bakhsi, MD^3*, Christopher Rees, MD^3*, Mark Griffiths, MD^3*, Deborah Leake, NP^3*, Carlton Dampier, MD³ and Claudia R. Morris, MD³

¹Department of Pediatrics, Emory University School of Medicine, Atlanta, GA
²Emory University School of Medicine, Atlanta, GA
³Department of Pediatrics, Emory University School of Medicine and Children’s Healthcare of Atlanta, Atlanta, GA

Golnar Mostashari^1*, Timothy Quang, PhD^2*, Helen E Parker, PhD^3*, Mai Hill, RN, BSN, MHSA^4*, Dina Parekh, MD^5*, Andrew Keel^2*, Anna Conrey^4*, Swee Lay Thein, MBBS, DSc, FRCP, FRCPath, MRCP, MRCPath⁶ and Bruce J Tromberg^3*

¹NICHD, National Institutes of Health, Bethesda, MD
²National Institutes of Health, Bethesda, MD
³National Institutes of Health, Bethesda
⁴Sickle Cell Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD
⁵Sickle Cell Branch, National Heart, Lung and Blood Institutes / NIH, Bethesda, MD
⁶Sickle Cell Branch, National Heart, Lung & Blood Institute, Bethesda, MD

Ramakrishna Ungalara^1*, Omika Katoch, Ph.D^2*, Tomasz Waldemar Kaminski, PharmD^2* and Tirthadipa Pradhan-Sundd, PhD³

¹University of Pittsburgh, Pittsburgh, PA
²Versiti Blood Research Centre, Milwaukee, WI
³Versiti Blood Research Institute, Milwaukee, WI

Carlos J Munoz, MS, BS^1*, Daniela Lucas, BS^1*, Cynthia R Muller, PhD^2*, Srila Gopal, MD^3,4 and Pedro Cabrales, PhD^5*

¹University of California San Diego, La Jolla, CA
²University of California, San Diego, La Jolla, CA
³University of California San Diego Health, San Diego, CA
⁴Division of Hematology/Oncology, University of California San Diego, San Diego, CA
⁵Functional Cardiovascular Engineering Laboratory, University of California, San Diego, La Jolla, CA

Ioannis Papassotiriou, PhD¹, Christos Poziopoulos, MD^2*, Eleni Pergantou, MD, PhD^3* and Ersi Voskaridou, MD^4*

¹First Department of Pediatrics, National and Kapodistrian University of Athens, School of Medicine, Athens, Attica, Greece
²Department of Hematology, Metropolitan Hospital, Neo Faliro, Greece
³Haemophilia Centre/Haemostasis and Thrombosis Unit, "Aghia Sophia" Children's Hospital, Athens, Greece
⁴Thalassaemia Centre, Laikon General Hospital, Athens, Greece

Jasmine Lewis, BSc^1*, Nicolas Prud'homme, MD, MSc^2*, Ellen Kennedy, BScN, RN^3*, Fatima Iqbal, BSc^4*, Amit Kalra, MBBS, MSc⁵, Pauline de Jesus, MSc^6*, Gurpreet Singh, MD, MSc^7*, Monica Bhatia, MD^8*, Faisal Khan, PhD^9*, Steven C. Greenway, MD, MSc^10* and Gregory M.T. Guilcher, MD¹¹

¹Department of Medicine, Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
²Department of Pediatrics, Division of Pediatric Hematology-Oncology, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire (CHU) Sainte-Justine, Montreal, QC, CAN
³Alberta Children's Hospital, Calgary, AB, Canada
⁴Department of Cardiac Sciences and Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
⁵University of Calgary, Calgary, AB, CAN
⁶Cumming School of Medicine, University of Calgary, Alberta Children's Hospital and Research Institute, Calgary, AB, Canada
⁷Department of Pediatrics and Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Alberta Children’s Hospital, Calgary, AB, CAN
⁸Division of Hematology, Oncology, and Stem Cell Transplant, Morgan Stanley Children’s Hospital, Columbia University, New York, NY, USA, New York, NY
⁹Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, CAN
¹⁰Departments of Pediatrics and Alberta Children's Hospital Research Institute, Cardiac Sciences and Libin Cardiovascular Institute, and Biochemistry & Molecular Biology, Cumming School of Medicine, University of Calgary, Alberta Children’s Hospital, Calgary, AB, Canada
¹¹Department of Pediatrics and Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Alberta Children’s Hospital, Calgary, AB, Canada

Luke Gingell, BS^1* and Borys Hrinczenko, MD, PhD^2*

¹Michigan State University College of Human Medicine, Grand Rapids, MI
²Hematology/Oncology, Michigan State University College of Human Medicine, East Lansing, MI

Wei Li, PhD^1*, Andrew Pucka, BS^2*, Candice Debats^2*, Brandon Reyes^2*, Andrew Ross Wickman O'Brien, MD³, Qigui Yu, MD, PhD^1* and Ying Wang, MD, PhD^2,3*

¹Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN
²Department of Anesthesia, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN
³Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN

Naveen Khargekar, MD^1*, Manisha Madkaikar^2*, Neha Kargutkar^3*, Anindita Banerjee^4*, Namrata Mahajan^1* and Kalpna Gupta, PhD⁵

¹ICMR-National Institute of Immunohaematology, Mumbai, India
²ICMR-National Institute of Immunohaematology, Mumbai, Maharashtra, IND
³ICMR-National Institute of Immunohaematology, Mumbai, AL, IND
⁴ICMR-National Institute of Immunohaematology, Mumbai, IND
⁵Hematology/Oncology Division, Department of Medicine, University of California, Irvine, CA

Summer Xia Han, PhD^*, Emily M Fitz, BSc^*, Allysa Allen^*, Avik Choudhuri, PhD^*, Caroline V Sartain^*, Paul A Bruno, PhD^*, Jeffrey W Jacobs, PhD^* and Billy Stuart, PhD^*

Fulcrum Therapeutics, Cambridge, MA