Amaliris Guerra, PhD^1*, Ariel Rivera, BA^1*, Nolan Hamilton^2*, Xiuli An, MD, PhD³, Nermi L. Parrow, PhD⁴, Yelena Ginzburg, MD⁵, Robert E. Fleming, MD⁶ and Stefano Rivella, phD⁷

¹Children's Hospital of Philadelphia, Philadelphia, PA
²Children's Hospital of Philadelphia, Philadelphia
³Zhengzhou University, New York, NY
⁴Saint Louis University School of Medicine, St Louis, MO
⁵Division of Hematology & Medical Oncology, Tisch Cancer Institute/ Icahn School of Medicine at Mount Sinai, New York, NY
⁶Saint Louis University, Saint Louis, MO
⁷Department of Pediatrics, University of Pennsylvania, Philadelphia, PA

Ali T Taher, MD, PhD, FRCP¹, Vip Viprakasit^2*, Antonis Kattamis, MD, PhD³, Silverio Perrotta^4*, Paolo Ricchi^5*, John B. Porter, MD^6*, Thomas D Coates^7,8, Gian Luca Forni^9*, Khaled M. Musallam^10*, Oriana Esposito^11*, Ana Carolina Giuseppi^12*, Wen-Ling Kuo^12*, Marta Reverte^11*, Richard Wei^12*, Luciana Moro Bueno^11* and Maria Domenica Cappellini¹³

¹Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
²Siriraj Research Hospital, Mahidol University, Bangkok, Thailand
³First Department of Pediatrics, National and Kapodistrian University of Athens, Athens, Greece
⁴Università della Campania, Luigi Vanvitelli, Caserta, Italy
⁵Malattie Rare Del Globulo Rosso, AORN A. Cardarelli, Naples, Italy
⁶University College London, University College London Hospitals, London, United Kingdom
⁷Cancer and Blood Disease Institute, Children’s Hospital Los Angeles, Los Angeles
⁸USC Keck School of Medicine, Los Angeles, CA
⁹Centro della Microcitemia e Anemie Congenite e del Dismetabolismo del Ferro, Ospedale Galliera, Genoa, Italy
¹⁰Thalassemia Center, Burjeel Medical City, Abu Dhabi, United Arab Emirates
¹¹Celgene International Sàrl, a Bristol-Myers Squibb Company, Boudry, Switzerland
¹²Bristol Myers Squibb, Princeton, NJ
¹³Fondazione IRCCS Ca’ Granda Policlinico Hospital, University of Milan, Milan, Italy

Kevin H.M. Kuo, MD, FRCPC, MSc^1,2, Pranee Sutcharitchan^3*, Ping Chong Bee^4*, Lee Ping Chew^5*, Soo Min Lim^6*, Ai Sim Goh^7*, Sadanand Vodala^8*, Wen-Ling Kuo^8*, Yinzhi Lai^8*, Loyse Felber Medlin^9*, Martina Perin^9*, Luciana Moro Bueno^9*, Thomas D Coates^10,11 and Vip Viprakasit^12*

¹Division of Medical Oncology and Hematology, Department of Medicine, University Health Network, Toronto, ON, Canada
²Division of Hematology, Department of Medicine, University of Toronto, Toronto, ON, Canada
³Chulalongkorn University, Bangkok, Thailand
⁴Pusat Perubatan Universiti Malaya, Kuala Lumpur, Malaysia
⁵Sarawak General Hospital, Sarawak, Malaysia
⁶Sultanah Aminah Hospital, Johor, Malaysia
⁷Hospital Pulau Pinang, Pulau Pinang, Malaysia
⁸Bristol Myers Squibb, Princeton, NJ
⁹Celgene International Sàrl, a Bristol-Myers Squibb Company, Boudry, Switzerland
¹⁰USC Keck School of Medicine, Los Angeles, CA
¹¹Children's Center for Cancer and Blood Diseases, Children's Hospital Los Angeles, Los Angeles, CA
¹²Siriraj Research Hospital, Mahidol University, Bangkok, Thailand

Maria Domenica Cappellini¹, Ali T Taher, MD, PhD, FRCP², Vip Viprakasit^3*, Pencho Georgiev^4*, Kevin H.M. Kuo, MD, FRCPC, MSc^5,6, Natalia Holot^7*, Valérie Vilmont^8*, Loyse Felber Medlin^8*, Wen-Ling Kuo^7*, Yinzhi Lai^7*, Luciana Moro Bueno^8* and Sujit Sheth, MD⁹

¹Fondazione IRCCS Ca’ Granda Policlinico Hospital, University of Milan, Milan, Italy
²Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
³Siriraj Research Hospital, Mahidol University, Bangkok, Thailand
⁴Medical University of Plovdiv, Plovdiv, Bulgaria
⁵Division of Medical Oncology and Hematology, Department of Medicine, University Health Network, Toronto, ON, Canada
⁶Division of Hematology, Department of Medicine, University of Toronto, Toronto, ON, Canada
⁷Bristol Myers Squibb, Princeton, NJ
⁸Celgene International Sàrl, a Bristol-Myers Squibb Company, Boudry, Switzerland
⁹Division of Pediatric Hematology/Oncology, Weill Cornell Medicine, New York, NY

Alessandro Mattè, BSc, PhD^1*, Angelo D'Alessandro, PhD², Mariarita Bertoldi, PhD^3*, Richard Huot Pozzetto^1*, Giovanni Bisello, PhD^4*, Andrea Mattarei, PhD^5*, Alberto Ongaro, PhD^5*, Alice Passarini^6*, Angela Siciliano^7*, Roberta Russo, PhD^8,9*, Achille Iolascon, MD, PhD^9,10*, Carlo Brugnara, MD¹¹ and Lucia De Franceschi, MD¹

¹Department of Medicine, University of Verona and AOUI Verona, Verona, Italy
²Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz School of Medicine, Aurora, CO
³Dept. of Neuroscience, Biomedicine and Movement, University of Verona, Verona, ITA
⁴Dept. of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy
⁵Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy
⁶Department of Medicine, University of Verona & AOUI Verona, Verona, Italy
⁷Department of Medicine, University of Verona & AOUI Verona, Verona, ITA
⁸Ceinge- Biotecnologie Avanzate, Naples, Italy
⁹University of Naples "Federico II", Naples, Italy
¹⁰Ceinge - Biotecnologie Avanzate, Naples, ITA
¹¹Lab of Medicine and Pathology, Children’s Hospital, Harvard Medical School, Boston, Boston, MA

Jackie Fretz, PhD^1*, Eileen Chua^2*, Xiuqi Li, PhD^2* and Karin E Finberg, MD, PhD²

¹Department of Orthopaedics & Rehabilitation, Yale School of Medicine, New Haven, CT
²Department of Pathology, Yale School of Medicine, New Haven, CT

Pokpong Piriyakhuntorn, MD^1*, Adisak Tantiworawit, MD¹, Piangrawee Niprapan, MNS^1*, Chanisa Thonusin, MD, PhD^2,3,4*, Tawika Kaewchur, MD^5*, Nipon Chattipakorn, MD, PhD^3,4,6* and Siriporn Chattipakorn, DDS, PhD^3,4,7*

¹Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
²Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, Chiang Mai University, Chaing Mai, Thailand
³Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
⁴Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Chiang Mai, Thailand
⁵Division of Nuclear Medicine, Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
⁶Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
⁷Department of Oral Biology and Diagnostic Sciences, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand