Rita V Masese, MD, MSc^1*, Lauren Siewny, MD^2*, Siera Gollan, PhD^3*, Jeffrey A. Glassberg, MD⁴, Victor R. Gordeuk, MD⁵, Jane S Hankins, MD, MS⁶, Cathy Melvin, PhD, MPH^7*, Liliana Preiss^8*, Paula Jean Tanabe, PhD, RN, FAEN, FAAN⁹, Marsha Treadwell, PhD¹⁰ and Allison A. King, MD, PhD, MPH¹¹

¹School of Nursing, Duke University, Durham, NC
²Department of Emergency Medicine, Duke University Hospital, Durham, NC
³Center for Blood Disorders, Medical College of Georgia, Augusta, GA
⁴Department of Emergency Medicine, Icahn School of Medicine at Mount Sinai, New York, NY
⁵Sickle Cell Center, University of Illinois at Chicago, Chicago, IL
⁶St. Jude Children's Research Hospital, Memphis, TN
⁷Department of Public Health Sciences, Division of Health Behavior and Health Promotion, Medical University of South Carolina, Charleston, SC
⁸RTI International, Durham, NC
⁹Duke University, Durham, NC
¹⁰Department of Pediatrics, Division of Hematology, University of California San Francisco Benioff Children's Hospital, Oakland, CA
¹¹School of Medicine, Washington University, Saint Louis, MO

Melissa Shyian, MD^* and Lauren Bolster, MD

University of Alberta, Edmonton, AB, Canada

Nicole Bohnker, MPH^1*, Antoine Haddad, BS^1*, Katherine Smith, MLT, SBB, CHS, BCPA^2*, Jessica Cox, RN, BSN, CPN^2*, Alexis Huber, RN, BSN^2*, Jennifer Light, MD^1,2* and Kay Linn Saving, MD^1,2

¹University of Illinois College of Medicine - Peoria, Peoria, IL
²OSF HealthCare Children's Hospital of Illinois, Peoria, IL

Mufaddal Mahesri, MD, MPH^1*, Su Been Lee, BA^1*, Raisa Levin, MS^1*, Suzan Imren, MD^2*, Lanju Zhang, PhD^2*, Lina Titievsky, PhD, MPH^2* and Rishi J Desai, PhD, MS^1*

¹Harvard Medical School/Brigham & Women's Hospital, Boston, MA
²Vertex Pharmaceuticals, Boston, MA

Maroun Bou Zerdan, MD^1*, Stephanie Niforatos, MD^1*, Prashanth Ashok Kumar, MBBS², Alanna Siegenthaler^3*, Mulham Ombada^4*, Melanie Kirk^5*, Andrulisa Jones^6*, Bhavya Poudyal^7*, Elad Levine^1*, Cathy Liu^1*, Joseph Repicky^8*, Mahinbanu Mammadli^9*, Parth Sampat, MBBS¹, Mahnoor Sherazi^10*, Matthew Ramm^4*, Sanjay Rao Gergal Gopalakrishna Rao^11*, Habib Layoun^12* and Teresa Gentile, MD, PhD¹³

¹SUNY Upstate Medical University Hospital, Syracuse, NY
²Upstate Cancer Center, Division of Hematology/Oncology, SUNY Upstate Medical University, SYRACUSE, NY
³Suny Upstate Medical University, Syracuse, NY
⁴SUNY Upstate Medical University, Syracuse, NY
⁵SUNY Upstate medical university hospital, Syracuse, NY
⁶SUNY Upstate Medical university Hospital, Syracuse, NY
⁷SUNY Upstate Medical University Hospital, syracuse, NY
⁸SUNY Upstate Medical Univeristy Hospital, Syracuse, NY
⁹SUNY Upstate Medical University, syracuse, NM
¹⁰SUNY Upstate Medical University Hospital, Syracuse
¹¹SUNY Upstate Medical University Hospital, Syacuse
¹²Cleveleand Clinic, Cleveland, OH
¹³Upstate Cancer Center, Division of Hematology/Oncology, SUNY Upstate Medical University, Syracuse, NY

Katie Parisio, DO¹, Elyse Andrews, MD^1*, Amanda M. Lewis, MPH^2* and Corinna L. Schultz, MD³

¹Nemours Children's Health, Wilmington, DE
²Center for Healthcare Delivery Science, Nemours Children's Health, Wilmington, DE
³Center for Cancer and Blood Disorders, Nemours Children's Health, Wilmington, DE

Anjali Oberoi, MD, MPH¹, Alison R Clarke, MD^2*, Traci M Kazmerski, MD, MS^2*, Seethal A Jacob, MD, MS³ and Maayan Leroy-Melamed, MD, MPH^4*

¹University of Massachusetts Chan Medical School, Boston, MA
²University of Pittsburgh Medical Canter, Pittsburgh
³Riley Hospital For Children, Indianapolis, IN
⁴Hasbro Children's Hospital, Providence

Jennifer Drahos, PhD, MPH^1*, Adriana Boateng-Kuffour^2*, Melanie Calvert^3*, Ashley Valentine^4*, Anthony Mason^5*, Nanxin Li, PhD, MBA¹, Zahra Pakbaz, MD⁶, Farrukh Shah, MD MBBS FRCPath⁷, Nick Ainsworth^8* and Antony P Martin^8*

¹Vertex Pharmaceuticals, Boston, MA
²Vertex Pharmaceuticals, Boston
³Centre for Patient-Reported Outcomes Research, University of Birmingham, Birmingham, United Kingdom
⁴Sick Cells, Washington, DC
⁵Sickle Cell Care Manchester, Manchester, United Kingdom
⁶Division of Hematology Oncology, University of California Irvine School of Medicine, Orange, CA
⁷NHS Blood and Transplant, London, GBR
⁸QC Medica, Liverpool, United Kingdom

Christopher Wanjiku, MD¹, Cyrus Githinji Njuguna, BSN^2*, David Lazris, MD^3*, Julia Xu, MD, MS⁴, Festus Njuguna, PhD^5*, Austin Okuku, CO^6* and Katherine MacDonald, MD, MPH^7*

¹Hematology/Oncology, University of North Carolina, Chapel Hill, durham, NC
²AMPATH/Moi Teaching and Referral Hospital, Eldoret, KEN
³Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA
⁴Vascular Medicine Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, PA
⁵AMPATH/Moi University, Eldoret, KEN
⁶Hematology and Oncology, AMPATH/Moi Teaching and Referral Hospital, Eldoret, Kenya
⁷Pediatrics/Adolescents, University of North Carolina Chapel Hill, Chapel Hill, NC

Mica Ferlis, NP^1*, Daniel Sop, MS, BS², Yue May Zhang, MS^1* and Wally R Smith, MD¹

¹Virginia Commonwealth University, Richmond, VA
²Sickle Cell Disease program / General Internal Medicine, Virginia Commonwealth University, Glen Allen, VA

Iuliia Kovalenko, MD¹, Mitali Shah^2*, Nelly Kiriza^3*, Enrico M Novelli, MD³, Laura M. Decastro, MD³ and Julia Xu, MD, MS³

¹University of Pittsburgh Medical Center (UPMC) Harrisburg Hospital, Harrisburg, PA
²Drexel University College of Medicine, Philadelphia
³Department of Medicine, University of Pittsburgh, Heart, Lung, Blood and Vascular Medicine Institute, Pittsburgh

Titilope Fasipe, MD, PhD¹, Anne Dykes, RN, MSN, CNS^2*, Devin Olivares-Reed^2*, Truc Baccam, RN, MS, MPH^2*, Krystle Bartley, MA^3*, Trinh T. Nguyen, DO¹, Elise Blair, MBA, BSN, RN, BMTCN^2*, Barkha Chandwani^2*, Sandra Knight, MSN, RN, NE-BC, CPHON^2*, Rhoda Phillips, MSN, RN, CPHON^2*, Alaundra Carmouche, DNP, APRN, FNP-C^1*, Kalindi Yajnik Narine, MD¹, Jennifer Tran, DO¹, Kathleen Magee, RN, PNP, MA^2*, Lisa Bomgaars, MD^1*, Binita Patel, MD^1*, Rona Sonabend, MD^1* and Venee Tubman, MD⁴

¹Baylor College of Medicine/Texas Children's Hospital, Houston, TX
²Texas Children's Hospital, Houston
³University of Texas Dell Medical School, Austin, TX
⁴Texas Children's Hospital, Houston, TX

Jin Han, PharmD^1*, Xu Zhang, PhD^2*, Binal Shah, PhD^3*, Santosh L. Saraf, MD⁴ and Victor R. Gordeuk, MD⁵

¹College of Pharmacy, University of Illinois Chicago, Chicago, IL
²UIC, Chicago, IL
³Department of Medicine, University of Illinois At Chicago, Chicago, IL
⁴Department of Medicine, University of Illinois College of Medicine, Willowbrook, IL
⁵Sickle Cell Center, University of Illinois at Chicago, Chicago, IL

Erik Hoyer, MD^1*, Daniel J. Brotman,, MD^2* and Michael Streiff, MD³

¹Physical Medicine and Rehabilitation, Johns Hopkins University, Baltimore, MD
²Johns Hopkins Hospital, Baltimore, MD
³Division of Hematology, Department of Medicine, Johns Hopkins Hospital, Baltimore, MD

Eric Scott Mullins, MD^1,2, Reilly Larcey, BA^3*, Andrea Meisman, MA^3* and Tanya Lilliane Kowalcyzk Mullins, MD, MS^2,3*

¹Division of Hematology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
²University of Cincinnati-College of Medicine, Cincinnati, OH
³Division of Adolescent and Transition Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

Alys Adamski, PhD, MPH^1*, Karon Abe, PhD^1*, Nimia Reyes, MD, MPH^1*, Barbara Braun^2*, Michele Bozikis^2*, Salome Chitavi^2*, Karen Kolbusz^2* and Stephen Schmaltz^2*

¹Division of Blood Disorders, Centers for Disease Control and Prevention, Atlanta, GA
²The Joint Commission, Oakbrook Terrace, IL

Lisa Baumann Kreuziger, MD, MS^1,2, Megan Keenan^3*, Hayley Dykhoff^4*, Marie Hall^3*, Kyle Campbell^3*, Emily Cahill, MPH, BS^5*, Ryan Hanson^6*, Dustin McEvoy^7*, Wei He^7*, Sayon Dutta, MD^7*, Rachel P. Rosovsky, MD⁸ and Damon E. Houghton, MD, MS⁹

¹Medical College of Wisconsin, Milwaukee
²Versiti, Menomonee Falls, WI
³Health Services Advisory Group, Phoenix, AZ
⁴Health Services Advisory Group, Phoeniz, AZ
⁵American Society of Hematology, Washington, DC
⁶Froedtert Hospital, Milwaukee, WI
⁷Massachusetts General Hospital, Boston, MA
⁸Division of Hematology & Oncology, Department of Medicine, Massachusetts General Hospital, Boston, MA
⁹Department of Cardiovascular Diseases, Division of Vascular Medicine & Dept of Medicine, Division of Hematology, Mayo Clinic, Rochester, MN

Hunter Tolison, BS^1*, Cassandra Duarte, MD², Glen Peterson, DNP^3*, Grace N Bosma, MS^4*, Diana Abbott, PhD¹, Gemlyn George, MD¹, Daniel Pollyea¹, Craig T. Jordan, PhD⁵ and Maria L Amaya, MD, PhD⁶

¹University of Colorado, Aurora, CO
²University of Colorado Cancer Center, Denver, CO
³School of Medicine, University of Colorado, Aurora, CO
⁴Division of Hematology, University of Colorado School of Medicine, Aurora, CO
⁵University of Colorado School of Medicine, Aurora, CO
⁶Division of Hematology, University of Colorado, Aurora, CO

Kelsey Uminski, MD^1,2, Natalia Rydz, MD, FRCPC^1,2 and M. Dawn Goodyear, MD, MSc^1,3

¹Southern Alberta Rare Blood and Bleeding Disorders Comprehensive Care Program, Calgary, Canada
²Division of Hematology and Hematological Malignancies, Department of Medicine, University of Calgary, Calgary, Canada
³Department of Medicine, Division of Hematology and Hematological Malignancies, University of Calgary, Calgary, AB, Canada

Josette M Kamel, MD^1*, Eliot Rapoport, MD^1* and Mark Chaitowitz, MD²

¹Montefiore Medical Center, The Bronx, NY
²Hematology, Montefiore Medical Center, Bronx, NY

Rachael F. Grace, MD¹, Lily Cannon^2*, Maaike Eijgenraam^3*, Carl Lander, RN^4*, Laura Miller D'Angelo^5*, Susan Morris, PhD^6*, Janie Davis^7*, Parija Patel, PharmD, MBA^6*, Tamara Schryver, PhD^8*, Alejandra Watson^9* and Wilma Barcellini, MD^10*

¹The Children's Hospital Corporation, Boston, MA
²Thalassaemia International Federation, Limassol, CYP
³Thrive with Pyruvate Kinase Deficiency, Nijmegen, Netherlands
⁴Thrive with PK Deficiency, Bath, United Kingdom
⁵Pyruvate Kinase Deficiency Foundation, Wolverine Lake
⁶Agios Pharmaceuticals, Inc., Cambridge, MA
⁷Agios Pharmaceuticals, Cambridge, MA
⁸Thrive with Pyruvate Kinase Deficiency Organization, Minneapolis, MN
⁹Pyruvate Kinase Deficiency Foundation, Walled Lake, MI
¹⁰Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

Biree Andemariam, MD¹, Ninamaria Badalamenti^2*, Rae Blaylark^3*, Ralph Colasanti^4*, Raffaella Colombatti, MD, PhD^5*, Rachael F. Grace, MD⁶, Charles R. Jonassaint, PhD, MHS⁷, Kevin H.M. Kuo, MD, FRCPC, MSc⁸, Laurice M Levine^9*, Clarisse Lobo, MD, PhD¹⁰, Tamara Schyrver^11*, Sujit Sheth, MD¹², Cassandra Trimnell, BA^13*, Alejandra Watson^14*, Jill Welle^15*, Teonna Woolford^16*, Holly John^17*, Janie Davis^17*, Ahmar U Zaidi, MD^18*, Eva Gallagher, PhD^17*, Sarah Gheuens, MD, PhD^18* and Nirmish Shah, MD¹⁹

¹University of Connecticut Health, Farmington, CT
²Independent Contributor, Indianapolis, IN
³Sickle Cell Foundation of Minnesota, Minneapolis, MN
⁴The Cooley’s Anemia Foundation, New York, NY
⁵Department of Woman's and Child's Health, Pediatric Hematology Oncology, University of Padova, Padova, Italy
⁶Boston Children's Hospital, Boston, MA
⁷University of Pittsburgh Medical Center, Pittsburgh, PA
⁸Division of Hematology, University of Toronto, Toronto, ON, Canada
⁹Independent Contributor, Petaluma, CA
¹⁰HEMORIO, Instituto De Hematologia Arthur Siqueira Cavalcanti, Rio de Janeiro, Brazil
¹¹Thrive with Pyruvate Kinase Deficiency Organization, Minneapolis, MN
¹²Division of Hematology and Oncology, Department of Pediatrics, Weill Cornell Medicine, New York, NY
¹³Sickle Cell 101, San Francisco, CA
¹⁴Pyruvate Kinase Deficiency Foundation, Walled Lake, MI
¹⁵Independent Contributor, Savage, MN
¹⁶Sickle Cell Reproductive Health Education Directive, Owings Mills, MD
¹⁷Agios Pharmaceuticals, Cambridge, MA
¹⁸Agios Pharmaceuticals, Inc., Cambridge, MA
¹⁹Division of Hematology–Duke Sickle Cell Comprehensive Care Unit, Duke University Medical Center, Durham, NC

Jun Yen Ng, BmedSci (Hons), MBBS, MClinTRes^1,2*, Savisha Fernando, MD^3*, Lisa Phipps, MBBS, MSC, FRACP^4*, Charmaine Wong, MBBS, FRACP, FRCPA⁵, Karen Fogo, BNSC, Grad Cert Nephrology Nursing^6*, Donna Crameri^3* and Douglas Stuart Lenton, MBBS, FRACP, FRCPA^7*

¹Haematology, Orange Health Service, Orange, Australia
²Haematology, Canberra Hospital, Canberra, ACT, Australia
³Orange Health Service, Orange, Australia
⁴Nephrology, Orange Health Service, Orange, Australia
⁵Haematology, Orange Health Service, Orange, AUS
⁶Nephrology, karen.fogo@health.nsw.gov.au, Orange, Australia
⁷Haematology, Orange Health Service, Orange, NSW, AUS

Akshee Batra, MBBS^1*, Rohit Singh, MD^2*, Saloni Savani, MD^3*, Diego Adrianzen Herrera, MD², Atulya Aman Khosla, MBBS⁴ and Claudio Brunstein^5*

¹Department of Internal Medicine, University of Vermont Medical Center, Winooski, VT
²Division of Hematology and Oncology, Larner College of Medicine at the University of Vermont, Burlington, VT
³Wills Knighton Health System, Shreveport, LA
⁴Department of Internal Medicine, Beaumont Hospital (Royal Oak), Troy, MI
⁵Cleveland Clinic, Cleveland, OH

Sara Khan, DO¹, Aruba Sohail^2*, Maryum Hassan^2*, Janta Ukrani, MD^3*, Areej Fatima, MBBS^2*, Muhammad Farooq, MD⁴ and Kapisthalam S. Kumar, MD⁵

¹Internal Medicine, HCA Healthcare/USF Morsani College of Medicine GME: Bayonet Point, Longwood, FL
²Dow University of Health Sciences, Karachi, Pakistan
³Mather Hospital/Northwell Health, New York, NY
⁴H Lee Moffitt Cancer Center and Research Institute, Tampa, FL
⁵Florida Cancer Specialists, Trinity, FL

Maria E. E Santaella, MSN, RN¹, Karina Raimundo^2*, Robert Schuldt, PhD^2* and Michael Recht, MD, PhD, MBA^1,3*

¹National Hemophilia Foundation, New York, NY
²Genentech, Inc., South San Francisco, CA
³Pediatric Hematology/Oncology, Yale University School of Medicine, New Haven, CT

Nicole M. Engel-Nitz, PhD^1*, Jackie Kwong, PhD, PharmD², Kevin Wang, MS^3*, Summer Tran, PharmD, PhD^4* and Amy Anderson, MS^5*

¹HEOR, Optum, Eden Prairie, MN
²Daiichi Sankyo Inc., Basking Ridge, NJ
³Daiichi Sankyo, Inc., Basking Ridge
⁴Optum, Eden Prairie
⁵HEOR, Optum, Eden Prairie

Christina Waldron, BS¹, Satoko Ito, MD, PhD², Daniel Wang, BS¹, Cecily Allen, MD³, Giri Viswanathan^4*, Robert D Bona, MD⁵, Adam Cuker, MD⁶ and George Goshua, MD, MSc²

¹Yale School of Medicine, New Haven, CT
²Section of Hematology, Department of Internal Medicine, Yale School of Medicine, New Haven, CT
³Division of Hematology, Department of Medicine, Johns Hopkins Hospital, Baltimore, Md
⁴Yale College, New Haven, CT
⁵Section of Hematology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT
⁶Department of Medicine and Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadephia, PA

Lourdes Gil-Flores, MD¹, Emilia Ramos-Barrera^2*, Andrea Flores-Díaz^3*, Lillian Sung, MD, PhD⁴, David Gomez-Almaguer, MD⁵ and Andres Gomez-De Leon, MD⁶

¹Universidad Autónoma de Nuevo León. Facultad de Medicina y Hospital Universitario "Dr. José Eleuterio González", Guadalupe, Mexico
²Escuela de Medicina y Ciencias de la Salud del Tecnológico de Monterrey, Monterrey, Mexico
³Universidad de Sonora. Departamento de Medicina y Ciencias de la Salud, Hermosillo, Mexico
⁴The Hospital for Sick Children, Toronto, ON, Canada
⁵Servicio de Hematologia, Universidad Autonoma de Nuevo Leon, Hospital Universitario "Dr. José Eleuterio Gonzalez", Monterrey, Mexico
⁶Universidad Autónoma de Nuevo León. Facultad de Medicina y Hospital Universitario "Dr. José Eleuterio González", Monterrey, Mexico

Katherine J Feder, MD, MS, HEC-C¹, Janice I. Firn, PhD, MSW, HEC-C^2,3* and Layla N Van Doren, MD, MBA⁴

¹Yale University School of Medicine, New Haven, CT
²University of Michigan Medical School, Department of Learning Health Sciences, Ann Arbor, MI
³University of Michigan Medical School, Center for Bioethics and Social Sciences in Medicine, Ann Arbor, MI
⁴Division of Hematology, Yale University, New Haven, CT

Lucas T Go^1*, Lewis T Go^2*, Madugodaralalaage DSK Gunaratne^3* and Jithma Prasad Abeykoon, MD⁴

¹Onalaska High School, ONALASKA, WI
²Onalaska High School, Onalaska, WI
³Hurley Medical Center, Flint, MI
⁴Mayo Clinic, Rochester, MN