Stephen E. Kurtz^1*, Christopher A. Eide^1*, Nicola Long^1*, Daniel Bottomly^1*, Shannon K McWeeney, PhD^1*, Akosha Taylor^1*, Brian J. Druker, MD², Sudarshan Anand^1*, Curtis A. Lachowiez, MD³ and Jeffrey W Tyner, PhD¹

¹Knight Cancer Institute, Oregon Health & Science University, Portland, OR
²Oregon Health & Science University, Portland, OR
³Knight Cancer Institute, Oregon Health & Science University, Houston, TX

Anastasiya Yudina, MSc^*, Anastasiya Danchurova, MSc^*, Lolita Alekseeva^*, Aleksei Efremov, MSc^*, Sergei Starikov^*, Danielle Sookiasian, BSc^*, Ekaterina Nuzhdina, MSc^*, Svetlana Podsvirova, MS^*, Madison Chasse, BSc^*, Tori Conroy, BSc^*, Noel English, BSc^*, Dmitry Tabakov, PhD^*, Sheila T. Yong^*, Artur Baisangurov, MSc^*, Cagdas Tazearslan, PhD^*, Nathan Fowler, MD^* and Alexander Bagaev, PhD^*

BostonGene, Corp., Waltham, MA

Azusa Nagao^1*, Yusuke Inagaki^2*, Keiji Nogami^3*, Naoya Yamasaki^4*, Fuminori Iwasaki^5*, Yang Liu^6*, Yoichi Murakami^6*, Takahiro Ito^6* and Hideyuki Takedani^7*

¹Ogikubo Hospital, Tokyo, Japan
²Nara Medical University, Nara, Japan
³Department of Pediatrics, Nara Medical University, Nara, Japan
⁴Hiroshima University, Hiroshima, Japan
⁵Kanagawa Children’s Medical Center, Kanagawa, Japan
⁶Chugai Pharmaceutical Co., Ltd, Tokyo, Japan
⁷National Hospital Organization Tsuruga Medical Center, Fukui, Japan

Candace Westgate^1*, Gilles Salles, MD, PhD², Stephannie Shih^3*, Margarita Lopatin^3*, Kathryn N. Kurtzman^3*, Katerina Kappes, BSc^4*, Oliver Venn, Ph.D^3*, Samir Parekh, MD⁴, Jeffrey M. Venstrom^3*, Anas Younes⁵ and Rita Shaknovich, MD, PhD³

¹Adventist Health, Saint Helena, CA
²Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
³GRAIL, LLC, Menlo Park, CA
⁴Mount Sinai Hospital, New York, NY
⁵AstraZeneca, New York, NY

Yanjing Vera Liu, PhD^1*, Jeremiah Suryatenggara, PhD^2*, Hannan Wong^2*, Jing Ping Tang^2*, Hong Kee Tan, PhD^2*, Junsu Kwon, PhD^2*, Qiling Zhou, PhD^2*, Simone Ummarino, PhD^3,4*, Alexander Ebralidze, PhD^5,6,7*, John G. Doench, PhD^8*, Li Chai, MD⁹, Touati Benoukraf, PhD^2*, Devendra Hiwase, MD, MBBS, PhD, FRACP, FRCPA^10,11,12, Daniel Thomas, MD, PhD^12,13,14, Annalisa Di Ruscio, MD, PhD^3*, Daniel G. Tenen, MD, PhD^2,4,6* and Mahmoud Adel Bassal, PhD, BS^2,4,6*

¹Broad Institute of MIT and Harvard, Boston, MA
²Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore
³Beth Israel Deaconess Medical Center, Boston, MA
⁴Harvard Stem Cell Institute, Boston, MA
⁵Harvard Medical School Initiative For RNA Medicine, Harvard Medical School, Boston, MA
⁶Hematology/Oncology, Beth Israel Deaconess Medical Center, Boston, MA
⁷Harvard Medical School, Boston, MA
⁸Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA
⁹Brigham And Women's Hospital, Boston, MA
¹⁰Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia
¹¹Australasian Leukaemia and Lymphoma Group (ALLG), Melbourne, VIC, Australia
¹²Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, Australia
¹³Blood Cancer, Precision Medicine Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia
¹⁴Haematology, Central Adelaide Local Health Network (CALHN), Adelaide, SA, Australia

Cedric De Almeida Braga, Ph D in training^1*, Maxence Bauvais^2*, Pierre Sujobert, MD, PhD^3*, Mael Heiblig^4*, Maxime Jullien, MD^5*, Baptiste Le Calvez^6*, Camille Richard^7*, Valentin Le Roc'h^7*, Emmanuelle Rault^8*, Olivier Herault, MD^9*, Pierre Peterlin^10*, Alice Garnier, MD^11*, Patrice Chevallier, MD¹², Simon Bouzy, PharmD^13*, Yannick LE Bris, PhD, PharmD^14*, Antoine Neel, Pr^15*, Julie Graveleau^16*, Perrine Paul-Gilloteaux, Ph D^17*, Olivier Kosmider, PharmD, PhD^18*, Nicolas Normand^19* and Marion Eveillard^20,21*

¹Nantes Université, Ecole Centrale Nantes, LS2N, UMR 6004, Nantes, France, Nantes, France
²Nantes University Hospital, Hematology biology, Nantes, France
³Laboratory of Hematology, Centre Hospitalier Lyon Sud, Pierre Bénite, France
⁴Hematology Department, Hôpital Lyon Sud, Vourles, Rhône Alpes, France
⁵Nantes University Hospital, NANTES, France
⁶Pediatric Hematology, Nantes, France
⁷Hematology biology, Nantes, France
⁸CHU Tours, Tours, France
⁹Centre Hospitalier Universitaire, Tours, FRA
¹⁰Hematology Department, Hôpital Hotel Dieu, NANTES CEDEX 1, France
¹¹Hematology clinic, Nantes University Hospital, Nantes, France
¹²Service d'hématologie, CHU de Nantes, Nantes, France
¹³Hematology biology, Nantes University Hospital, Nantes, France
¹⁴CHU Nantes, Nantes, France
¹⁵Service de Médecine Interne-Médecine Vasculaire, CHU de Nantes, Nantes, France
¹⁶Saint Nazaire Hospital, Saint Nazaire, France
¹⁷Nantes University, MicroPICell, INSERM, Nantes, France
¹⁸Laboratory of Hematology, Université Paris Cité and Assistance Publique-Hôpitaux de Paris. Centre, Hôpital Cochin, Paris, France
¹⁹Polytech, Nantes Université, école centrale Nantes, CNRS, LS2N, UMR 6004, Nantes, France
²⁰Hematology biology, CHU Nantes, Nantes, France
²¹CRCI²NA, INSERM, Nantes, France

Anil Yüce^1*, Christian Doerig^1*, Jacob Gildenblat^1,2*, Samaneh Abbasi-Sureshjani^1*, Agata Mosinska^1*, Heather Wright^1*, Wilfred Leung, PhD^3*, Yanwen Jiang, PhD^3*, Patrick Kimes, PhD^3*, Camille Laurent, MD, PhD^4*, Konstanty Korski^1* and Markus D Herrmann^1*

¹F. Hoffmann-La Roche AG, Basel, Switzerland
²DeePathology, Ra'anana, Israel
³Genentech, Inc., South San Francisco, CA
⁴Pathology Department, Institut Universitaire du Cancer , Oncopole, Toulouse, France

Jessica A.O. Zimmerman, MD, MS^1,2, Abigail M. Morrison^3*, Hunter Mennenga^1*, Mimi Fang, MS^2,3* and Miles A. Pufall, PhD^2,3*

¹Stead Family Department of Pediatrics - Hematology/Oncology, University of Iowa, Iowa City, IA
²Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA
³Department of Biochemistry and Molecular Biology, University of Iowa, Iowa City, IA

Somin Jung^*, William J. Wulftange, MSc, BS^*, Payam Fadaei, MSc^*, Yuncheng Man, PhD^* and Umut A. Gurkan, PhD

Case Western Reserve University, Cleveland, OH

Edwin Wei Sheng Thong, MBBS, MRCP^1*, Andrew Makmur, MBBS, BmedSc, FRCR^2*, Yen-Lin Chee, MBChB, PhD, MRCP, FRCP, MRCPath, FRCPath^1*, James Hallihan, MBChB (Hon), BSc (Hon), FRCR^2*, Lenith Tai Jit Cheng, MBBS, FRCR, MMed (Diag Rad)^2*, Nesaretnam Barr Kumarakulasinghe, MBBS, MRCP, FAMS (Medical Oncology), MSc Health Informatics^1*, Anand Devaprasath Jeyasekharan, MBBS, MRCP, PhD^1*, Joanne Shu Xian Lee, MBBS (UK), MRCP (UK), FRCPath^3*, Sanjay De Mel, BSc, FRCPath, MRCP^1*, Esther Hian Li Chan, MBBS, MRCP, FRCPath^3*, Michelle Poon^3*, Wee-Joo Chng, MBBS, PhD, FRCPath, FRCP³, Jayalakshmi ., MSc Medical Microbiology^1*, Melati Dewi Ali, MSc Medical Ultrasound^2*, Wei-Ying Jen, MD, FRCPath, MA^3* and Desmond Shi Wei Lim, MBBS, FRCR, MMed (Diag Rad)^2*

¹Department of Haematology-Oncology, National University Cancer Institute, Singapore, Singapore, Singapore
²Department of Diagnostic Imaging, National University Hospital, Singapore, Singapore
³Department of Haematology-Oncology, National University Cancer Institute, Singapore, Singapore

Aditya S Deshpande, PhD^1*, Max F. Levine^1*, Kevin Hadi^1*, Gunes Gundem^1,2*, Minal Patel^1*, Stan Skrzypczak^1*, Andrew L. Kung^1,3, Juan S Medina-Martínez^1* and Elli Papaemmanuil^1,3

¹Isabl Inc., New York, NY
²Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY
³Memorial Sloan Kettering Cancer Center, New York, NY

Maher Albitar, MD¹, Hong Zhang, MD^1*, Andrew Ip, MD MSc², Wanlong Ma, MT(ASCP)^1*, James McCloskey, MD³, Katherine Linder, MD^2*, Jeffrey Justin Estella^1*, Jamie Koprivnikar, MD^2*, Noa Biran, MD⁴, David S. Siegel, MD, PhD⁵, Ahmad Charifa, MD^1*, Arash Mohtashamian, MD¹, Andrew L Pecora, MD² and Andre Goy, MD⁶

¹Genomic Testing Cooperative, Irvine, CA
²Hackensack University Medical Center, Hackensack, NJ
³The John Theurer Cancer Center at Hackensack Meridian Health, Hackensack, NJ
⁴Multiple Myeloma Division, John Theurer Cancer Center, Hackensack Meridian Health, Hackensack, NJ
⁵Multiple Myeloma Division, Hackensack Univ. Med. Ctr., Hackensack, NJ
⁶Lymphoma Division, John Theurer Cancer Center, Hackensack Meridian Health, Hackensack, NJ

Edgar Baculi, BSc^1*, Vineela Kadiyala, PhD^2*, Long Tan, BS^2*, Bach Nguyen, PhD^2*, Nhung Huynh, PhD^2*, Tengyao Song^2*, Gwo-Jen Day^2*, Lin Yuan, MS^2*, Michael Bates³ and Huilin Wei, MD, PhD^2*

¹Hematology Oncology R&D, Cepheid, San Jose, CA
²Hematology Oncology R&D, Cepheid, Sunnyvale, CA
³Cepheid, Sunnyvale, CA

Angus Hodder, MBBS^1*, Sarah Leiter^2*, Aditi Vedi, MBBS^3*, Phillipa May^1*, Dilys Addy^1*, Phil Ancliff^1*, Julian Cano-Flanagan^1*, Jane Chalker^4*, Danny Cheng, MA, MBBS, MRCP^1*, Yasmin Clinch^4*, Caryl Dryden^1*, Sara Ghorashian^1*, David O'Connor, MD^1*, Vesna Pavasovic^1*, Anupama Rao, MD, MRCPath^1*, Sujith Samarasinghe^1*, Iryna Stasevich^1*, Ajay Vora, MD¹, Michael Hubank^5,6*, Dame Lyn Chitty^6,7*, Sam Behjati, PhD^2* and Jack Bartram^1,6*

¹Department of Haematology, Great Ormond Street Hospital for Children, London, United Kingdom
²Sanger Institute, Cambridge, United Kingdom
³Paediatric Haematology/Oncology, Cambridge University Hospitals, Cambridge, United Kingdom
⁴Royal Marsden NHS Foundation Trust, London, United Kingdom
⁵The Institute of Cancer Research, London, United Kingdom
⁶North Thames Genomic Laboratory Hub, London, United Kingdom
⁷Genome Biology and Precision Medicine Section, UCL Great Ormond Street Institute of Child Health, London, United Kingdom

Erica N Evans^1*, Evelyn K Williams, BS^2*, Celeste K. Kanne, MS¹, Kirby A Fibben^2*, Ashwin P. Patel, MD, PhD, MPH¹, Lindsey Abel, BS^1*, Meredith Ellen Fay, PhD^2*, Akshay A Patwardhan^1*, Jawa Darazim, BS^1*, Zachary Kostamo, BS^1*, Wilbur Lam, MD, PhD^1,3 and Vivien A. Sheehan, MD, PhD¹

¹Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA
²Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA
³Wallace H. Coulter Department of Biomedical Engineering,, Georgia Institute of Technology and Emory University, Atlanta, GA

Agnes Sebastian, MTech^1*, Sanju S, MTech^1*, Bindhu Paul-Prasanth, PhD^1*, Neeraj Sidharthan, MD, MBBS, DM, DNB² and Vidya Jha, MD^3*

¹School of Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham, Kochi, India
²Department of Clinical Haematology and Bone Marrow Transplantation, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India
³Department of Cytogenetics, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham, ERNAKULAM, AL, India

Dennis J Wu, PhD^1*, Amy S Chen^1*, Nikki Deangelis, PhD^2*, Diana Cortes, PhD^3*, Jose Morachis, PhD^1*, Benjamin Titz, PhD^1*, Sylvaine Cases, PhD^1*, Raluca Verona, PhD³ and Chorom Pak, PhD^1*

¹Lynx Biosciences, Inc., San Diego, CA
²Janssen Biotech, Horsham, PA
³Janssen Research & Development, Spring House, PA

Alexander Glover¹, Mark Bishton, MD, PhD², Matthew Ahearne^3*, Kaljit Bhuller^4*, Steve Jones^5*, Graham P. Collins, MBBS, DPhil⁶, Lindsay George, PhD, FRCPath^7*, Conal McConville^8*, Allister Foy^9*, Catherine Hildyard^10*, Catherine Moore, PhD^11*, Christopher P. Fox, MD, PhD^12,13 and Claire Shannon-Lowe, PhD^14*

¹University of Birmingham, Nottingham, United Kingdom
²Translational Medical Sciences, University of Nottingham, Nothingham, United Kingdom
³Leicester Cancer Research Centre, Leicester Royal Infirmary, Leicester, United Kingdom
⁴University Hospitals Leicester, Leicester, United Kingdom
⁵Kings Mill Hospital, Sutton-in-Ashfield, GBR
⁶Haematology, Oxford Cancer and Haematology Centre, Oxford, ENG, United Kingdom
⁷Birmingham Children's Hospital, Birmingham, GBR
⁸Altnagelvin Area Hospital, Portadown, GBR
⁹Craigavon Area Hospital, Craigavon, United Kingdom
¹⁰Milton Keynes University Hospital, Milton Keynes, GBR
¹¹Public Health Wales Microbiology Cardiff, Cardiff, United Kingdom
¹²Department of Haematology, Nottingham City Hospital, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom
¹³School of Medicine, University of Nottingham, Nottingham, United Kingdom
¹⁴University of Birmingham, Birmingham, ENG, GBR

Karsten CA Miermans, PhD^1*, Hannes Lüling^2*, Aleksandra Mezydlo^2*, Franz Elsner^2*, Felix Kunzweiler^2*, Felix Spöttel^2*, Artur Toloknieiev^2*, Florian Pfisterer^2*, Tim Adler^2*, João Moura Alves^2*, Holger Hauspurg, MD³ and Jurgen Alois Riedl, PhD, MD^4*

¹hema.to GmbH, München, Germany
²hema.to GmbH, Munich, Germany
³Institut für Pathologie und Hämatopathologie, Hamburg, Germany
⁴Result Laboratorium, Dordrecht, Netherlands

Martin M. K. Schneider, MD^1*, Freya Schulze, MD^1*, Tim Schmittmann^2*, Sebastian Riechert, MSc^2,3*, Miriam Eva Helena Gediga, MD^1*, Katja Sockel, MD^1*, Frank P. Kroschinsky, MD, MBA¹, Karsten Wendt, PhD^2,3*, Martin Bornhaeuser, MD^1,4, Jan Moritz Middeke, MD^1,3* and Jan-Niklas Eckardt^1,3*

¹Department of Internal Medicine I, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany
²Institute of Software and Multimedia Technology, Technical University Dresden, Dresden, Germany
³Else Kroener Fresenius Center for Digital Health, Technical University Dresden, Dresden, Germany
⁴National Center for Tumor Disease (NCT) Dresden, Dresden, Germany

Martha-Lena Mueller, PhD^1*, Sven Maschek, BA^2*, Lisa Erdl^1*, Adriane Koppelle, MD^1*, Claudia Haferlach, MD¹, Manja Meggendorfer, PhD¹, Torsten Haferlach, MD, PhD¹ and Wolfgang Kern, MD¹

¹MLL Munich Leukemia Laboratory, Munich, Germany
²MLL Munich Leukemia Laboratory, Munich, AL, Germany

Jiasen He, MD^1,2, Christin Silos, MS^2,3*, Stuart Fraser, MD^2,3*, Natalie A Montanez^2,3,4*, Audrey Barnett^5,6*, Keely Smith, MD^2,3* and Lakshmi Venkat Srivaths, MD^2,3,4

¹MD Anderson Cancer Center, Houston, TX
²University of Texas Health Science Center at Houston, Houston, TX
³UTHealth Institute for Stroke and Cerebrovascular Disease, Houston, TX
⁴Gulf States Hemophilia and Thrombophilia Center, Houston, TX
⁵Texas EMS, Acute Care, and Trauma Foundation (TETAF), Houston, TX
⁶Memorial Hermann Health System, Houston, TX

Maher Albitar, MD¹, Hong Zhang, MD^1*, Andrew Ip, MD, MSc², Wanlong Ma, MT(ASCP)^1*, Jeffrey Justin Estella^1*, Lori A. Leslie, MD³, Tatyana Feldman, MD⁴, Ahmad Charifa, MD^1*, Arash Mohtashamian, MD¹, Andrew L Pecora, MD⁵ and Andre Goy, MD²

¹Genomic Testing Cooperative, Irvine, CA
²Lymphoma Division, John Theurer Cancer Center, Hackensack Meridian Health, Hackensack, NJ
³Lymphoma Division, John Theurer Cancer Center, Hackensack Meridian School of Medicine, Hackensack, NJ
⁴John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, NJ
⁵Hackensack University Medical Center, Hackensack, NJ

Chieh Hwee Ang, MD, FRCPath, MRCP^1,2*, Tertius Tansloan Tuy, MD, MRCP(UK)^1,2*, Tze Wei Chan, MBBS, MRCP(UK)^1,2*, Christopher Tham, BMBCh, MRCP(UK)^1,2*, Si Jie Khoo, BSc(Hons), MSc^1*, Gee Fung How, BSc(Hons), PhD^1*, Charles Chuah, MBChB, MRCP(UK), FRCP(Edin)^1,2* and Hein Than, MD, FRCPath, MRCP^1,2

¹Department of Haematology, Singapore General Hospital, Singapore, Singapore
²National Cancer Centre Singapore, Singapore, Singapore

Oscar Berlanga, PhD^1*, Jane Birtwistle, PhD^1*, Syreeta Allen, BSc^1*, Gemma Malin, BSc^1*, Cristina Simion, BSc^1*, Habib El-Khoury, MD^2*, Julia Colchie, MA^2*, Luca Bertamini, MD^2*, Grace Fleming, BSc^2*, Erica M. Horowitz, BA^2*, Irene M. Ghobrial, MD², Kaleb B McLendon, BSc^3*, John Roback, MD, PhD^4*, Andrew S Neish, MD^3*, Sarah K Grewal, DO^3* and Gabriella Lakos¹

¹The Binding Site, Birmingham, United Kingdom
²Dana-Farber Cancer Institute, Boston, MA
³Emory University School of Medicine, Atlanta, GA
⁴Emory University Hospital Blood Bank, Atlanta, GA

Vikram Dhillon, DO, MBA^1,2, Jeff Aguilar, MD, MBA³ and Suresh Kumar Balasubramanian, MD^4,5

¹Department of Hematology/Oncology, Neal Cancer Center/Houston Methodist Hospital, Detroit, MI
²Department of Oncology, Karmanos Cancer Center/Wayne State University, Detroit, MI
³Department of Oncology, Karmanos Cancer Institute/Wayne State University, Windsor, ON, Canada
⁴Karmanos Cancer Institute/Department of Oncology, Wayne State University, Detroit, MI
⁵Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH

Akshay A Patwardhan^1*, Solomon Oshabaheebwa, MS^2*, Christopher A. Delianides, MS^2*, Zoe Sekyonda, BS^2*, Ashwin P Patel, MD, PhD, MPH¹, Erica N Evans^1*, Justin J Yoo, MD³, Lindsey Abel, BS^1*, Michael A. Suster, PhD^2*, Pedram Mohseni, PhD^2*, Umut A. Gurkan, PhD² and Vivien A Sheehan, PhD¹

¹Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA
²Case Western Reserve University, Cleveland, OH
³Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University School of Medicine, Avondale Estates, GA

Eric D. Hsi, MD¹, Magdalena Czader, MD, PhD^2*, Brian T. Hill, MD³, Elizabeth Thacker^4*, Lin Wang, PhD^2*, Christopher Giauque^5*, Andrea Vrydaghs^6*, Matt Sperling^6*, Jordan Bouldin^5*, Robert Erno^5*, Lanie Happ^4*, Clayton Parker, MS^4*, Cassandra L. Love⁷, Jennifer Shingleton^7* and Sandeep Dave, M.D.^8*

¹Department of Pathology, Wake Forest Baptist Medical Center, Winston Salem, NC
²Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN
³Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
⁴Data Driven Bioscience, Durham, NC
⁵Wake Forest University Hospital, Winston-Salem, NC
⁶Indiana University Hospital, Indianapolis, IN
⁷Duke University, Durham, NC
⁸Duke University Medical Center, Durham, NC