Laurianne Scourzic, PhD¹, Franco Izzo, PhD², Lucretia Cucereavii^1*, Matthew Teater, PhD^3*, Alexander Polyzos, PhD^1*, Christopher Chin, PhD^4*, Coraline Mlynarczyk, PhD¹, Ioanna Tsialta^1*, Robert M Myers, PhD⁵, Wendy Beguelin, PhD^6*, Matthias Stadtfeld, PhD^1*, Zhengming Chen, PhD^7*, Dan A. Landau, MD, PhD^8*, Ari M Melnick, MD³ and Eftychia Apostolou, PhD^1*

¹Weill Cornell Medicine, New York, NY
²Division of Hematology and Medical Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York
³Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY
⁴Department of Medicine, Weill Cornell Medicine, New York, NY
⁵Tri-Institutional MD-PhD Program, Weill Cornell Medicine, Rockefeller University, Memorial Sloan Kettering Cancer Center, New York, NY
⁶Department of Medicine, Weill Cornell Medical College, New York, NY
⁷Weill Cornell medicine, New York, NY
⁸Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY

Franziska Auer, PhD^1*, Mina Morcos, PhD^2*, Mikko Sipola^3*, Sanni Moisio, MSc^4*, Anna Viitasalo^3*, Aleksandra Pandyra^5*, Arndt Borkhardt⁵, Merja Heinäniemi^3* and Julia Hauer^2*

¹Technical University of Munich, School of Medicine, Department of Pediatrics, Neufahrn Bei Freising, Bavaria, Germany
²Technical University of Munich, School of Medicine, Department of Pediatrics, Munich, Germany
³Institute of Biomedicine, School of Medicine, University of Eastern Finland, Yliopistonranta 1, FI-70211, Kuopio, Finland
⁴Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland
⁵Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical faculty, Heinrich Heine University Düsseldorf, Duesseldorf, Germany

Zhangliang Cheng^*, Kohei Kume, PhD^* and Markus Müschen, MD

Center of Molecular and Cellular Oncology, Yale University, New Haven, CT

Kerstin Wenzl, PhD^1*, Matthew E Stokes^2*, Joseph P. Novak^1*, Allison M. Bock, MD³, Melissa A. Hopper, BS, MS⁴, Jordan Krull, PhD^5*, Abigail R. Dropik, BS⁴, Janek S. Walker, PhD⁴, Miranda S. Laverty^5*, Vivekananda Sarangi^4*, Raphael Mwangi, M.S.^6*, Maria Ortiz^7*, Nicholas Stong^7*, C. Chris Huang, PhD^2*, Matthew J. Maurer, DSc⁶, Lisa M. Rimsza, MD⁸, Brian K. Link, MD^9*, Rebecca King, MD^4*, Stephen M Ansell, MD, PhD¹, Thomas M. Habermann, MD¹, Thomas E. Witzig, MD⁴, Grzegorz S. Nowakowski, MD¹, James R. Cerhan, MD, PhD¹⁰, Anita K. Gandhi, PhD⁷ and Anne J. Novak, PhD⁴

¹Division of Hematology, Mayo Clinic, Rochester, MN
²Bristol Myers Squibb, Summit, NJ
³Division of Hematology and Medical Oncology, Mayo Clinic, Rochester
⁴Mayo Clinic, Rochester, MN
⁵Mayo Clinic, Rochester
⁶Department of Health Sciences Research, Mayo Clinic, Rochester, MN
⁷Bristol Myers Squibb, Princeton, NJ
⁸Department of Laboratory Medicine and Pathology, Mayo Clinic, Phoenix, AZ
⁹Division of Hematology, Oncology, and Blood & Marrow Transplantation, University of Iowa Hospitals and Clinics, Iowa City, IA
¹⁰Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN

Jianping Li, MD¹, Marta Kulis, PhD^2*, Alberto Riva, PhD^3*, Heidi Casellas Román^1*, Daphne Dupere-Richer, PhD^1*, Monica Clerio^1*, Melanie L. Trejo^1*, Michael Menes^1*, Anthony Joseph Lamberto^1*, Amin Sobh, PhD¹, Charlotte Leonie Kaestner, PhD¹, Richard Lynn Bennett, PhD¹, Iñaki I. Martin Subero, PhD^2* and Jonathan D. Licht, MD¹

¹University of Florida, Gainesville, FL
²Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
³ICBR Bioinformatics, Cancer and Genetic Research Complex, University of Florida, Gainesville, FL

Aleksandra Zolyniak^1*, Dorota Komar, PhD^2,3*, Sonia Debek, MSc, BA^2*, Filip Garbicz^2*, Michal Pawlak, PhD^2* and Przemysław Juszczyński, MD, PhD^4*

¹Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warszawa, Poland
²Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland
³Eurecat, Centre Tecnològic de Catalunya, Centre for Omic Sciences (COS), Joint Unit Univeristat Rovira i Virgili-EURECAT, Unique Scientific and Technical Infrastructures (ICTS), Reus, Spain
⁴Institute of Hematology and Transfusion Medicine, Warsaw, Poland

Marc Braunstein, MD, PhD¹, Patrick Blaney, MS^2,3* and Gareth J. Morgan, M.D., Ph.D.^2*

¹Perlmutter Cancer Center, Multiple Myeloma Research Program, NYU Grossman Long Island School of Medicine, NYU Langone Health, Great Neck, NY
²Perlmutter Cancer Center, Multiple Myeloma Research Program, NYU Grossman School of Medicine, NYU Langone Health, New York, NY
³Applied Bioinformatics Laboratories, NYU Grossman School of Medicine, NYU Langone Health, New York, NY

Jonathan J Morgan, PhD^*, Bryony G Kennedy, MSc^*, Rich Williams, PhD^*, Ken I Mills, BSc, PhD, FRCPath and Lisa J Crawford, BSc, PhD^*

Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, NI, United Kingdom

Ruimeng Yang, PhD^1*, Xuxiang Liu, PhD^2*, Jibin Zhang, Ph.D.^2*, Yuping Li, PhD^3*, Krystie Chew^4*, Claire Wu^5*, Jasmine M. Zain, MD⁶, Joo Y. Song, MD⁷, Waseem Gul Lone, PhD^8*, Javeed Iqbal, PhD, MSc^8* and Wing C. Chan, MD⁷

¹City of Hope, Duarte, CA
²City of Hope National Medical Center, Duarte, CA
³Anatomy Pathology, National Medical Centre City of Hope, Duarte, CA
⁴City of Hope, Los Angeles
⁵City of Hope, Los Angeles, China
⁶Department of Hematology & Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA
⁷Beckman Research Institute, City of Hope, Duarte, CA
⁸Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE

Jie Li^1*, Christopher Chin, PhD^1*, Hsia-Yuan Ying^1*, Cem Meydan^2*, Matthew Teater, PhD^3*, Min Xia, PhD³, Pedro Farinha⁴, Katsuyoshi Takata^4*, Chi-Shuen Chu^5*, Martin A Rivas, PhD, MS¹, Amy Chadburn, MD⁶, Christian Steidl, MD, PhD⁷, David W. Scott, MBChB, PhD⁸, Robert G. Roeder^5*, Christopher Mason^2*, Wendy Beguelin, PhD^9* and Ari M Melnick, MD³

¹Department of Medicine, Weill Cornell Medicine, New York, NY
²Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY
³Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY
⁴BC Cancer Centre for Lymphoid Cancer, Vancouver, BC, Canada
⁵The Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY
⁶Department of Pathology and Laboratory Medicine, Weill Cornell Medicine/New York Presbyterian Hospital, New York, NY
⁷Centre for Lymphoid Cancer, BC Cancer, Vancouver, BC, Canada
⁸Centre for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, BC, Canada
⁹Department of Medicine, Weill Cornell Medical College, New York, NY

Amy Sexauer, MD, PhD^1* and David Sykes, MD, PhD²

¹Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA
²Massachusetts General Hospital, Boston, MA

Valentina Fragliasso, PhD^1*, Veronica Manicardi, PhD^2*, Annalisa Tameni^3*, Selene Mallia, Ph.D.^4*, Benedetta Donati^5*, Federica Torricelli^5*, Emanuele Vitale^4*, Magda Zanelli, MD^1*, Stefano Luminari, MD⁶, Stefano Ascani^7*, Francesca Sanguedolce, M.D.^8*, Noemi Puccio, MSc^4*, Antonino Neri, MD^4* and Alessia Ciarrocchi, PhD^5*

¹Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy, ITA
²Azienda USL-IRCCS Reggio Emilia, Reggio Emilia, ITA
³Laboratory of Translational Research, Azienda USL-IRCCS, Reggio Emilia, ITA
⁴Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy
⁵Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, ITA
⁶Hematology, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy
⁷Hematology, CREO, University of Perugia, Perugia, ITA
⁸University of Foggia, Foggia, Italy

Han Leng Ng, PhD^1*, Mark E Robinson, PhD^2*, Valeria Malysheva, PhD^3*, Ozgen Deniz, MSc, BSc, PhD^4*, Nicholas Crump, PhD^5*, Kadriye Nehir Cosgun, PhD^2*, Kaiyue Helian, MSc^6*, Mikhail Spivakov, PhD^7*, Markus Müschen, MD⁸ and Niklas Feldhahn, PhD^9*

¹Immunology & Inflammation, Centre for Haematology, Imperial College London, London, United Kingdom
²Center of Molecular and Cellular Oncology, Yale University, New Haven, CT
³Computational Neurobiology, Department of Biomedical Sciences, VIB Center for Molecular Neurology, University of Antwerp, Antwerp, Belgium
⁴Barts Cancer Institute, Queen Mary University of London, LONDON, United Kingdom
⁵Hugh & Josseline Langmuir Centre for Myeloma Research Centre for Haematology, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom
⁶Department for Immunology & Inflammation, Imperial College London, London, United Kingdom
⁷London Institute for Medical Sciences, London, United Kingdom
⁸Center of Molecular and Cellular Oncology, Yale Cancer Center, Yale School of Medicine, New Haven, CT
⁹Immunology&Inflammation, Centre for Haematology, Imperial College London, London, ENG, United Kingdom

Huimin Liu^1*, Junzhe Song^1,2*, Mark E Robinson, PhD^3*, Gang Xiao, PhD^2,4* and Markus Müschen, MD⁵

¹Liangzhu Laboratory, Zhejiang University, Hangzhou, China
²Department of Immunology, Zhejiang University, Hangzhou, China
³Center of Molecular and Cellular Oncology, Yale University, New Haven, CT
⁴School of Medicine, Zhejiang University, Hangzhou, China
⁵Center of Molecular and Cellular Oncology, Yale Cancer Center, Yale School of Medicine, New Haven, CT

Valentina Minciacchi^1*, Christina Karantanou^2*, Costanza Zanetti^1*, Rahul Kumar, PhD^3*, Theresa Krack^1*, Nathalie Thomasberger^1*, Pablo Llavona^1*, Sylvia Hartmann^4*, Veronique Maguer-Satta^5*, Sylvain Lefort^6*, Mateusz Putyrski^7*, Andreas Ernst^7*, Eshwar Meduri^8*, Brian Huntly, PhD^9*, Wolfram Ruf, MD¹⁰ and Daniela S. Krause, MD¹¹

¹Georg-Speyer-Haus, Frankfurt Am Main, DEU
²Georg-speyer-Haus, Frankfurt, DEU
³Georg-Speyer-Haus, Frankfurt, Hessen, DEU
⁴Klinikum Der Goethe-Universität Frankfurt, Frankfurt, Germany
⁵CRCL, Lyon, FRA
⁶CRCL, Lyon, France
⁷Fraunhofer Institute For Molecular Biology and Applied Ecology IME, Project Grou, Frankfurt Am Main, DEU
⁸University of Cambridge, Cambridge, United Kingdom
⁹Jeffrey Cheah Biomedical Centre, Cambridge, GBR
¹⁰University, Mainz, DEU
¹¹Brigham, Inc., Frankfurt Am Main, Germany