Benjamin Bateman, BS^1*, Briana Bates, MS^2*, Michael Deininger, MD, PhD^2,3 and Helong Gary Gary Zhao, PhD^2,3

¹Versiti Blood Research Institute, Oak Creek, WI
²Versiti Blood Research Institute, Milwaukee, WI
³Medical College of Wisconsin, Milwaukee, WI

Junji Ikeda, MD^1,2*, Hiroyoshi Kunimoto, MD², Yusuke Saito, MD, PhD³, Shin-Ichi Tsujimoto, MD^1*, Takayuki Kurosawa^1*, Masanobu Takeuchi, MD, PhD^1*, Ayaka Miura, BS^2*, Koichi Murakami, MD, PhD^4*, Ikuma Kato, MD, PhD^5*, Takako Hishiki, PhD^6*, Noriyo Hayakawa, PhD^6,7*, Tomomi Matsuura, MS^6,7*, Megumi Funakoshi-Tago, PhD^8*, Akihiko Yokoyama, PhD^9*, Kenichi Yoshida, MD, PhD¹⁰, Daisuke Tomizawa, MD, PhD¹¹, Satoru Miyano, PhD^12*, Akio Tawa, MD, PhD^13*, Souichi Adachi, MD, PhD^14*, Seishi Ogawa^15,16, Yasuhide Hayashi, MD, PhD^17*, Norio Shiba, MD, PhD¹⁸, Tomohiko Tamura, MD, PhD⁴, Shuichi Ito, MD, PhD^1* and Hideaki Nakajima, MD, PhD²

¹Department of Pediatrics, Yokohama City University Graduate School of Medicine, Yokohama, Japan
²Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan
³Division of Clinical Cancer Genomics, Hokkaido University Hospital, Sapporo, Japan
⁴Department of Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
⁵Department of Molecular Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
⁶Department of Biochemistry, Keio University School of Medicine, Tokyo, Japan
⁷Clinical and Translational Research Center, Keio University School of Medicine, Tokyo, Japan
⁸Division of Hygienic Chemistry, Keio University, Faculty of Pharmacy, Tokyo, Japan
⁹Tsuruoka Metabolomics Laboratory, National Cancer Center, Yamagata, Japan
¹⁰Division of Cancer Evolution, National Cancer Center Research Institute, Tokyo, Japan
¹¹Division of Leukemia and Lymphoma, Children’s Cancer Center, National Center for Child Health and Development, Tokyo, Japan
¹²Department of Integrated Analytics, M&D Data Science Center, Tokyo Medical and Dental University, Tokyo, Japan
¹³Department of Pediatrics, Higashiosaka Aramoto Heiwa Clinic, Higashiosaka, Japan
¹⁴Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan
¹⁵Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan
¹⁶Department of Pathology and Tumor Biology, Kyoto University Graduate School of Medicine, Sakyoku, KYO, Japan
¹⁷Department of Hematology/Oncology, Gunma Children's Medical Center, Shibukawa, Japan
¹⁸Department of Pediatrics, Yokohama City University Graduate School of Medicine, Kanagawa, Japan

Yuichiro Semba, MD, PhD^1*, Takuji Yamauchi, MD, PhD^2*, Fumihiko Nakao, MD^3*, Jumpei Nogami, PhD^2*, Seishi Ogawa⁴, Takahiro Maeda, MD, PhD² and Koichi Akashi, MD, PhD^2*

¹Division of Precision Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
²Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
³National Hospital Organization Kyushu Medical Center, Fukuoka, Japan
⁴Department of Pathology and Tumor Biology, Kyoto University Graduate School of Medicine, Sakyoku, KYO, Japan

Geethu Emily Thomas, PhD, MSc, BSc^1*, Kazem Nouri, PhD^2*, Jong Bok Lee, PhD^3*, Rose Hurren^4*, Yongran Yan^5*, Neil Maclean^4*, Yulia Jitkova^4*, Li Ma^5*, Xiaoming Wang^6*, Chaitra Sarathy, PhD^4*, Andrea Arruda^7*, Mark D. Minden^8*, Li Zhang^3*, Vito Spadavecchio^9* and Aaron D. Schimmer, MD¹⁰

¹UHN, Princess Margaret Cancer Research Centre, Toronto, ON, Canada
²UHN, Toronto, ON, Canada
³UHN, Toronto General Hospital, Toronto, ON, Canada
⁴UHN, Princess Margaret Cancer Centre, Toronto, ON, Canada
⁵University Health Network, Princess Margaret Cancer Centre, Toronto, ON, Canada
⁶UHN , PMH, Toronto, On, CAN
⁷Princess Margaret Cancer Centre, University Health Network, Toronto, Canada
⁸Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
⁹Interlinked Therapeutics LLC, Portland, OR
¹⁰Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada

Aristi Damaskou^1,2*, Rachael Wilson^1,2*, Vijay Shanmugiah^1,2*, Justyna Rak^1,2*, Konstantinos Tzelepis, PhD^3*, Berthold Gottgens^1,2, Malgorzata Gozdecka^1,2* and George Vassiliou, FRCPath, MRCP, PhD, MBBS^1,2

¹Department of Haematology, University of Cambridge, Cambridge, United Kingdom
²Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
³University of Cambridge, Cambridge, United Kingdom

Hiroki Hayashida, MD^1*, Toshiya Hino, MD^1*, Ken Morita, MD^1*, Yosuke Masamoto, MD^1,2 and Mineo Kurokawa, MD, PhD^1,2

¹Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
²Department of Cell Therapy and Transplantation Medicine, The University of Tokyo Hospital, Tokyo, Japan

Alison E Meyer, PhD, Katelyn Heimbruch, MD, PhD^*, Cary Stelloh^*, Kirthi Pulakanti^* and Sridhar Rao, MD, PhD

Versiti Blood Research Institute, Milwaukee, WI

Cristoforo Grasso^1*, Peter Brazda^1*, Brigit M. te Pas^1*, Gitanjali Dharmadhikari^1*, Joost B. Koedijk^1,2*, Bianca F. Goemans, MD, PhD¹, Olaf Heidenreich, PhD^3,4, Mirjam E. Belderbos, MD, PhD³, C. Michel Zwaan, Prof. Dr.^1,2*, Hendrik G. Stunnenberg, PhD^1,5* and Wout Megchelenbrink^1*

¹Princess Maxima Centre for Pediatric Oncology, Utrecht, Netherlands
²Department of Pediatric Oncology, Erasmus MC/Sophia Children's Hospital, Rotterdam, Netherlands
³Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
⁴Wolfson Childhood Cancer Research Centre, Newcastle University, Newcastle upon Tyne, United Kingdom
⁵Nijmegen Centre For Molecular Life Sciences, Nijmegen, Netherlands

Xiaorong Gu, PhD^1*, Dongxu Jiang, PhD², Simon Schlanger, MS^2*, Nakisha D Williams, MBBS^1*, Divya Jyoti Singh^2*, Daniel Vail, PhD^2*, Jill Durkin^2*, Yahan Zhang, MS², Valeria Visconte, PhD^1*, Jaroslaw P. Maciejewski, M.D., Ph.D., FACP¹ and Babal Kant Jha, PhD^1,2*

¹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
²Center for Immunotherapy & Precision Immuno-Oncology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH

Jie Zhou, MD^1*, Wenjun Zhang, PhD^1*, Baoqing Yang, MMSc^1*, Hao Wu^1*, Bing Li^1*, Shaoguang Li, MD², Aibin Liang, MD, PhD^1* and Jianfei Fu, MD, PhD^1*

¹Department of Hematology, Tongji Hospital of Tongji University, Shanghai, China
²University of Massachusetts Medical School, Worcester, MA

Conny K. Baldauf^1*, Emmanouil Charakopoulos^2*, Martin Böttcher^2,3*, Vanja Zeremski^2*, Dimitrios Mougiakakos^2,3,4, Burkhart Schraven^3,4,5* and Thomas Fischer^3,4,5

¹Institute for Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University Magdeburg, Magdeburg, AL, Germany
²Department of Hematology and Oncology, Medical Faculty, Otto-von-Guericke University Magdeburg, Magdeburg, Germany
³Health-Campus Immunology, Infectiology, and Inflammation (GC-I3), Medical Faculty, Otto-von-Guericke University Magdeburg, Magdeburg, Germany
⁴Center for Health and Medical Prevention – CHaMP, Otto-von-Guericke University Magdeburg, Magdeburg, Germany
⁵Institute for Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University Magdeburg, Magdeburg, Germany

Yu Liu^1*, Chengcai Guo^1*, Wenbing Liu^1*, Xiaoyu Liu^1*, Qing Rao, MS^1*, Runxia Gu, MD^2*, Shaowei Qiu, MD^2*, Min Wang^3* and Jianxiang Wang, MD³

¹State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
²National Clinical Research Center for Blood Diseases, State Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Tianjin, China
³State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Tianjin, China

Miriam Frech, PhD^1*, Janine Schaprian^1*, Miriam Ems^1*, Sabine Teichler, PhD^1*, Uta-Maria Bauer, PhD^2* and Andreas Neubauer, MD³

¹Clinic for Hematology, Oncology, Immunology, and Center for Tumor Biology and Immunology (ZTI), Philipps University Marburg, Marburg, Germany
²Institute for Molecular Biology and Tumor Research (IMT), Philipps University Marburg, Marburg, Germany
³Department of Hematology, Oncology and Immunology, Phillips-University Marburg, Marburg, Germany, Marburg, Germany

Michael H. Kramer, MD, PhD¹, Stephanie Richardson^2*, Yang Li^2*, Nichole Helton^2*, Daniel George^2*, Michelle Cai, MD^3*, Sai Mukund Ramakrishnan, MS^2*, Christopher A Miller, PhD^2* and Timothy J Ley²

¹Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO
²Division of Oncology, Department of Internal Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO
³Division of Oncology, Department of Internal Medicine, Washington University in St. Louis, St. Louis, MO

Subham K. Bandyopadhyay, MSc^1,2*, Anwesha Bose, MSc^1,2*, Arnab Chattopadhyay, MD^3*, Subhadeep Ghosh, MSc^1,2*, Satyaki Bhowmik, MSc^1,2*, Sambit K. Samanta, MD, DM^3*, Maitreyee Bhattacharyya, MD, DM^3* and Amitava Sengupta, PhD^1,2*

¹Stem Cell & Leukemia Lab, Cancer Biology & Inflammatory Disorder Division, IICB-Translational Research Unit of Excellence, CSIR-Indian Institute of Chemical Biology, Kolkata, India
²CSIR-Human Resource Development Centre, Academy of Scientific & Innovative Research (AcSIR), Ghaziabad, India
³Institute of Haematology & Transfusion Medicine, Medical College & Hospital, Kolkata, India

Zelong Cui^1*, Man Xu^1*, Zhenxing Gao^1*, Minran Zhou^1*, Yue Fu^2*, Huimin Feng^1*, Lu Zhang^1* and Chunyan Chen^1*

¹Qilu Hospital of Shandong University, Jinan, China
²School of Basic Medical Sciences, Shandong University, Jinan, China

Alexandra Lubin, PhD¹, Catherine Hockings, FRCPath, MBBChir, MRCP, MA^1*, Yvette Hoade, BSc^1*, Lucy Copper, MSci^1*, Phoebe Dace, BSc^1*, Catherine Zhu, MB BChir^1*, Helen Brown, PhD^1*, Ellen Nuttall Musson^1*, Katie-Jo Miller, BSc^1* and Elspeth Payne, MD, PhD, FRCPath^1,2

¹Haematology, Cancer Institute, University College London, London, United Kingdom
²Department of Haematology, University College London Hospital, London, United Kingdom

Jane J Xu, PhD^1*, Yi Chen, MD, PhD^2*, John Pantazi^2*, Sebastian Fernando^3*, Besmira Alija^2*, Varun Sudunagunta, BA⁴, Govind Bhagat, MD⁵, Robert L. Bowman, PhD⁶ and Aaron D. Viny, MD, MS⁷

¹Columbia University Irving Medical Center, Department of Medicine, Division of Hematology / Oncology, New York, NY
²Columbia Stem Cell Initiative, Columbia Irving Medical Centre, New York, NY
³Columbia Stem Cell Initiative, Columbia Irving Medical Centre, New York
⁴Columbia University Vagelos College of Physicians and Surgeons, NEW YORK, NY
⁵Department of Pathology, Columbia University Irving Medical Center, New York, NY
⁶Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA
⁷Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY

Ting Lu^1*, Shangda Yang^2*, Cong Chen^3*, Shan Liu^4*, Guohuan Sun^4*, Hui Cheng^2*, Tao Cheng⁴ and Kuangyu Yen, PhD^4*

¹State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences&Peking Union Medical College, Tianjin, Tianjin, China
²State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Tianjin, China
³Tianjin Medical University, Tianjin, China
⁴State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences&Peking Union Medical College, Tianjin, China

Casey Katerndahl, PhD¹, Olivia Rogers^2*, Nichole Helton^3*, Sai Mukund Ramakrishnan, MS^3*, Christopher A Miller, PhD^3*, Ziheng Xu^4*, Sridhar N Srivatsan^5* and Timothy J Ley³

¹Stem Cell Biology Section, Washington University in St. Louis, Saint Louis, MO
²Washington University St Louis, Saint Louis, MO
³Division of Oncology, Department of Internal Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO
⁴Washington University School of Medicine, St Louis, MO
⁵Washington University in St. Louis, St. Louis, MO

John A Chadwick^1*, Bettina Wingelhofer, PhD^2* and Tim CP Somervaille, PhD FRCP FRCPath³

¹Cancer Research UK Manchester Institute, Manchester, ENG, United Kingdom
²Cancer Research UK Manchester Institute, Manchester, United Kingdom
³Cancer Research UK Manchester Institute, Manchester, GBR

Siqi Yi, Ph.D^1*, Shaela Wright^1*, Meixia Che, Ph.D^2*, Judith Hyle^1*, Shelby Mryncza^3*, Beisi Xu, PhD^4*, Yong Cheng, PhD⁵, Yajun Jiang, Ph.D^2* and Chunliang Li, PhD¹

¹St. Jude Children's Research Hospital, Memphis, TN
²Nanjing University, Nanjing, China
³St. Jude Children's Research Hospital, Memphis
⁴St. Jude Children Research Hospital, Memphis, TN
⁵St. Jude Children's Rsesearch Hospital, Memphis, TN

Meaad Saeed Almowaled^1,2,3*, Lijun Liu, BSc MSc^4*, Karen Dunn^5*, Myint Myat Khine Aung, MSci^4*, Gillian Horne, FRCPath PhD MRCP MRes^4*, Juerg Schwaller, MD⁶ and Karen Keeshan, PhD BSc^4*

¹School of Cancer Sciences, University of Glasgow, Glasgow, ENG, United Kingdom
²College of Applied Medical Sciences, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia
³King Abdullah International Medical Research Centre, Jeddah, Saudi Arabia
⁴School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom
⁵Paul O’Gorman Leukaemia Research Centre, School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom
⁶University Children's Hospital Basel, Department of Biomedicine, University of Basel, Basel, Switzerland

Chiharu Ishikawa, BS^1,2, Laura Barreyro, PhD³, Avery Sampson^2*, Kathleen Hueneman, MBA^2*, Kwangmin Choi, PhD^2*, Lyndsey C. Bolanos, MBA, BSc^2*, Andrew Volk, PhD², Stephanie S Watowich, PhD⁴, Kenneth Greis, PhD^5* and Daniel T. Starczynowski, PhD^1,2,6

¹Department of Cancer Biology, University of Cincinnati, Cincinnati, OH
²Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
³Janssen Research & Development, LLC, Spring House, PA
⁴UT M.D. Anderson Cancer Ctr., Houston, TX
⁵University of Cincinnati College of Medicine, Cincinnati, OH
⁶Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH

Yaqun Xu^*, Kathy Yuen Yee Chan, PhD^*, Siu Ping Fok^*, Yixuan Wu^*, Chi Kong Li and Kam Tong Leung^*

Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong

Tanmoy Sarkar, PhD¹, Shweta Singh, PhD¹, Kristbjorn Gudmundsson, PhD^1,2*, Holly Morris^1*, Shyam Sharan, PhD^1* and Jonathan Keller, PhD^1,2

¹Mouse Cancer Genetics Program - Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD
²Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD

Christopher Peter Mill, PhD, BA¹, Warren C. Fiskus, BSc, PhD², Courtney D. DiNardo, MD, MSc³, Patrick K Reville, MD, MPH³, John Davis^1*, Christine Birdwell, PhD¹, Kaberi Das^2*, Hanxi Hou^4*, Koichi Takahashi, MD, PhD³, Sanam Loghavi, MD⁵, Joseph D. Khoury, MD⁶ and Kapil N. Bhalla, MD²

¹MD Anderson Cancer Center, Houston, TX
²UT MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴The University of Texas MD Anderson Cancer Center, Houston, TX
⁵Hematopathology, MD Anderson Cancer Center, Houston, TX
⁶Department of Pathology, University of Nebraska Medical Center, Omaha, NE

Dongxu Jiang, PhD^1,2, Yihong Guan, PhD^2*, Shinjini Ganguly^2*, Aysegul Balyimez^2*, Andrew Muskara^2*, Divya Jyoti Singh^2*, Simona Pagliuca, MD, PhD³, Daniel Vail, PhD^1,2*, Yahan Zhang^1,2*, Jill Durkin^1,2*, Naomi Kawashima, MD, PhD^2*, Xiaorong Gu, PhD^2*, Carmelo Gurnari, MD², Jaroslaw P. Maciejewski, M.D., Ph.D., FACP², Omar Mian^2* and Babal K. Jha, PhD, MPhil, MSc, BSc^1,2

¹Center for Immunotherapy & Precision Immuno-Oncology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH
²Department of Translational Hematology and Oncology Research, Taussig Cancer Institute; Lerner Research Institute; Cleveland Clinic, Cleveland, OH
³Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland, OH