Subbaiah Chary Nimmagadda^1,2*, Pradeep Kumar Patnana, PhD^1,2*, Paulina Marie Budde^2*, Helal Ahmed, MBBS^1,2*, Todd Covey, PhD^3*, Cecile Krejsa, PhD³, Wayne Rothbaum, MS^4*, Nikolas Von Bubnoff, Prof., MD^1,5* and Cyrus Khandanpour, Prof., MD^1,2,5

¹Department of Hematology and Oncology, University Hospital Schleswig-Holstein, Campus Luebeck, Luebeck, Germany
²Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital Muenster, Muenster, Germany
³Kartos Therapeutics Inc., Redwood City, CA
⁴Kartos Therapeutics, Inc., Redwood City, CA
⁵University Cancer Center Schleswig-Holstein, Campus Luebeck, Luebeck, Germany

Morgane Boichut^1*, Margaux Poussard^1*, Imane Belakri^1*, Xavier Roussel^1*, Sabeha Biichle^1*, Maxime Fredon^1*, Florian Renosi^2*, Eric Deconinck³, Christopher Brooks^4*, Francine Garnache Ottou, PhD^5* and Fanny Delettre, PhD^1*

¹INSERM, UMR1098-RIGHT, EFS Bourgogne Franche-Comté, Université Bourgogne Franche-Comté, BESANCON, France
²Université de Franche-Comté, CHU Besançon, EFS, INSERM, UMR RIGHT, BESANCON, France
³Besançon University Hospital, Besançon, France
⁴Stemline Therapeutics, New York, NY
⁵CHU Besancon, Cellular immunology and hematology laboratory, Université de Franche-Comté, CHU Besançon, EFS, INSERM, UMR RIGHT, Besançon, France

Silvia Romero-Murillo^1,2*, Irene Peris, PhD^3*, Nerea Marcotegui^1*, Carmen Vicente, PhD^1,4*, Maria D. Odero, MD, PhD^1,2,4,5* and Goutham Narla, MD, PhD³

¹Centro de Investigación Médica Aplicada (CIMA), University of Navarra, Pamplona, Spain
²Department of Biochemistry and Genetics, University of Navarra, Pamplona, Spain
³Division of Genetic Medicine, Department of Internal Medicine, The University of Michigan Medical School, Ann Arbor, MI
⁴Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain
⁵CIBERONC, Instituto de Salud Carlos III, Madrid, Spain

Constanze Schneider, PhD^1,2*, Shan Lin, PhD^3,4*, Angela H Su^1,2*, Gabriela Alexe, PhD^3,5* and Kimberly Stegmaier, MD^1,6,7

¹Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA
²Broad Institute of MIT and Harvard, Cambridge, MA
³The Broad Institute of MIT and Harvard, Cambridge, MA
⁴Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children’s Hospital, Boston, MA
⁵Pediatric Oncology, Dana-Farber Cancer Institute, Boston
⁶Boston Children's Hospital, Boston
⁷The Broad Institute of MIT and Harvard, Cambridge

William M Yashar^1,2,3, Mitsuhiro Tsuchiya^3,4*, Akram Taherinasab, PhD^3,4*, Sara Evans-Dutson^4,5*, Brendan O'Connell, PhD^4,5,6*, Theresa Lusardi, PhD^4,5, Nicole Szczepanksi^4,5*, Galip Gurkan Yardimci, PhD^4,5*, Andrew C Adey, PhD^4,5,6*, Julia E Maxson, PhD^3,4 and Theodore P Braun, MD, PhD^3,4,7

¹Oregon Health & Science University, Portland, OR
²Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR
³Division of Oncologic Sciences, Oregon Health & Science University, Portland, OR
⁴Knight Cancer Institute, Oregon Health & Science University, Portland, OR
⁵Cancer Early Detection Advanced Research Center, Oregon Health & Science University, Portland, OR
⁶Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR
⁷Division of Hematology & Medical Oncology, Oregon Health & Science University, Portland, OR

Samarpana Chakraborty^1,2, Claudia Morganti^3*, Joyoti Dey, PhD, MPH^4*, Hui Zhang^2*, Srinivas Aluri, PhD^5*, Nadege Gitego^3*, Kith Pradhan^3*, Bianca Rivera, PhD^6*, Yogesh Chutake^4*, Anna Skwarska, PhD^7*, Ioannis Mantzaris⁸, Mendel Goldfinger, MD^8*, Eric J Feldman, MD^8*, Gaurav S Choudhary, PhD^3*, Stefan Hubner^9*, Yihua Qiu^10*, Brandon D. Brown, MD^11*, Amit Verma, MD^12,13,14,15, Evripidis Gavathiotis, CPA, PhD, BSc^16*, Marina Y. Konopleva⁸, Steven M. Kornblau, MD¹⁰, Jared Gollob^4*, Keisuke Ito, MD, PhD^3,17 and Aditi Shastri, MD^6,8,18,19

¹Department of Oncology, Albert Einstein College of Medicine, New York, NY
²Albert Einstein College of Medicine, New York, NY
³Albert Einstein College of Medicine, Bronx, NY
⁴Kymera Therapeutics, Watertown, MA
⁵Montefiore Einstein Cancer Center, Blood Cancer Institute, Department of Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY
⁶Blood Cancer Institute, Department of Oncology, Albert Einstein College of Medicine, Bronx, NY
⁷Cancer Center, Albert Einstein College of Medicine, New York, NY
⁸Department of Oncology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY
⁹John Sealy School of Medicine, The University of Texas Medical Branch (UTMB), Galveston, TX
¹⁰Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
¹¹Department of Pediatrics, MD Anderson Cancer Center, Houston, TX
¹²Hematology/Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY
¹³Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY
¹⁴Department of Medical Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY
¹⁵Department of Medical Oncology, Albert Einstein College of Medicine, Bronx, NY
¹⁶Albert Einstein College of Medicine, New York
¹⁷Department of Cell Biology/Stem Cell Institute and Medicine, Albert Einstein College of Medicine, Bronx, NY
¹⁸Department of Oncology, Montefiore Medical Center/ Albert Einstein College of Medicine, Bronx, NY
¹⁹Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY

Jevon Cutler, PhD¹, Jonathan Tsai, MD, PhD^2,3,4*, Brandon Regalado^1*, Wallace Bourgeois, MD⁵, Daniela Wenge, MD^1*, Jeonghyeon Kim^1*, Radoslaw Nowak, PhD^6,7*, Elizabeth Ener^1*, Katherine Donovan, PhD^8*, Sarah Naomi Olsen, PhD, BS, MS^1*, Eric Fischer, Ph.D.^9,10*, Benjamin L. Ebert, MD, PhD^11,12,13,14 and Scott A Armstrong, MD, PhD¹⁵

¹Dana-Farber Cancer Institute, Boston, MA
²Division of Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
³Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA
⁴Broad Institute of MIT, Cambridge, MA
⁵Boston Children's/dana-Farber, Boston, MA
⁶Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston
⁷Cancer Biology, Dana-Farber Cancer Institute, Boston, MA
⁸Dana Farber Cancer Institute, Boston, MA
⁹Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA
¹⁰Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA
¹¹Broad Institute of MIT and Harvard University, Cambridge, MA
¹²Howard Hughes Medical Institute, Boston, MA
¹³Department of Medicine, Harvard Medical School, Boston, MA
¹⁴Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
¹⁵Pediatric Oncology, Dana-Farber Cancer Institute, Boston

John Pollard^1*, Graham Craggs^1*, Gillian Farnie^2*, Matthew Fawkes^1*, Oleg Fedorov^3*, Charline Giroud^3*, Fenella Gross^1*, Joe Harman^1*, Alison Maloney, PhD^4*, Thomas Arthur Milne⁵ and Iain Simpson^1*

¹Dark Blue Therapeutics, OXFORD, United Kingdom
²Cancer Research Horizons, The Francis Crick Institute, London, United Kingdom
³Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, OXFORD, United Kingdom
⁴Dark Blue Therapeutics, OXFORD,, ENG, United Kingdom
⁵MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom

Tessa Seale^1*, Li Li, MD^2*, J. Kyle Bruner^3*, Bao Nguyen^1*, Mark J. Levis, MD, PhD⁴, Christine Pratilas^3* and Donald Small, MD, PhD¹

¹Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD
²Johns Hopkins Univ. School of Med., Baltimore, MD
³Johns Hopkins University School of Medicine, Baltimore, MD
⁴Division of Hematologic Malignancies, Johns Hopkins University, Baltimore, MD

Margaux Poussard^1*, Morgane Boichut^1*, Imane Belakri^1*, Sabeha Biichle^1*, Maxime Fredon^1*, Florian Renosi^2*, Francine Garnache Ottou, PhD^3*, Krystal Watkins^4*, Callum Mortimer Sloss, PhD^4*, Patrick A. Zweidler-McKay, MD, PhD⁴ and Fanny Delettre, PhD^1*

¹INSERM, UMR1098-RIGHT, EFS Bourgogne Franche-Comté, Université Bourgogne Franche-Comté, BESANCON, France
²Université de Franche-Comté, CHU Besançon, EFS, INSERM, UMR RIGHT, BESANCON, France
³CHU Besancon, Cellular immunology and hematology laboratory, Université de Franche-Comté, CHU Besançon, EFS, INSERM, UMR RIGHT, Besançon, France
⁴ImmunoGen, Inc., Waltham, MA

Kalay Bertulfo, MS, MA, MPhil^1,2, Koen Debackere, MD, PhD^1*, Hannah Miller^1*, Ryan Najac^1*, Cindy Ma^1*, Adolfo A. Ferrando, MD, PhD^1,3* and Teresa Palomero, PhD¹

¹Institute for Cancer Genetics, Columbia University Irving Medical Center, New York, NY
²Department of Biological Sciences, Columbia University, New York, NY
³Regeneron Pharmaceuticals Inc., Tarrytown, NY

Bogdan Popescu, MD^1*, Elliot Stieglitz, MD² and Catherine C. Smith, MD¹

¹Department of Medicine, Division of Hematology/Oncology, University of California San Francisco, San Francisco, CA
²Department of Pediatrics, Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA

Takayuki Ikezoe, MD, PhD¹, Taro Tachibana^2,3*, Chiaki Hata^2*, Cai-Xia Wang^2*, Daisuke Koyama^4*, Noboru Oriuchi^5*, Ken-ichi Nishijima^5*, Naoyuki Ukon^5*, Saki Shimoyama^5*, Taiki Joho^5*, Kohshin Washiyama^5*, Kazuhiro Takahashi^5* and Songji Zhao^5*

¹Fukushima Medical University, Fukushima, Japan
²Cell Engineering Corporation, Osaka, Japan
³Department of Bioengineering, Graduate School of Engineering, Osaka Metropolitan University, Osaka, Japan
⁴Fukushima Medical University, Fukushima, JPN
⁵Advanced Clinical Center, Fukushima Global Medical Science Center, Fukushima Medical University, Fukushima, Japan

Miranda van der Lee^1*, Tanja van Achtenberg^1*, Annet Brouwers-Vos^2*, Monique van der Vleuten^1*, Wendy Kappers^1*, Gijs Verheijden^1*, Gerwin A. Huls, Prof.³, Glenn van Wigcheren^1*, Ruud Ubink^1*, Aloys Sesink^1*, Alyson MacInnes^1*, Jan Jacob Schuringa, PhD⁴ and Wim Dokter^1*

¹Byondis BV, Nijmegen, Netherlands
²University Medical Center Groningen, University of Groningen, Groningen, Netherlands
³University Medical Center Groningen, Groningen, Netherlands
⁴Department of Experimental Hematology, University Medical Center - Groningen, Groningen, Netherlands

Bofei Wang, Ph.D.^1*, Patrick K Reville, MD, MPH¹, Fatima Z Jelloul^2*, Poonam N Desai¹, Pamella Borges^1*, Christopher Ly^3*, Ivo Veletic, MD^1*, Enes Dasdemir^4*, Jared K. Burks, PhD^1*, Guilin Tang, MD PhD^5*, Shengnan Guo^6*, Nicole Vaugh^4*, Natalia Baran, MD, PhD, MSc⁷, Qing Deng^8*, Jairo Matthews, BA^4*, Preethi Gunaratne^9*, Dinler A Antunes^10*, Suhendan Ekmekcioglu^4*, Koji Sasaki, MD¹¹, Miriam B. Garcia, DO^12*, Branko Cuglievan⁷, Dapeng Hao^6*, Naval Daver, MD¹, Michael R. Green, PhD¹³, Marina Y. Konopleva¹⁴, Andy Futreal, PhD^15*, Sean M. Post, PhD¹⁶ and Hussein A Abbas, MD, PhD¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, The University of Texas at MD Anderson Cancer center, Houston, TX
⁴The University of Texas at MD Anderson Cancer center, Houston, TX
⁵Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX
⁶Harbin Medical University, Harbin, China
⁷The University of Texas MD Anderson Cancer Center, Houston, TX
⁸The University of Texas at MD Anderson Cancer cent, Houston, TX
⁹Department of Biology and Biochemistry, University of Houston, Houston, TX
¹⁰University of Houston, Houston, TX
¹¹Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
¹²Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX
¹³Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Friendswood, TX
¹⁴Department of Oncology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY
¹⁵UT MD Anderson Cancer Center, Houston, TX
¹⁶MD Anderson, Houston, TX

Mariam Murtadha, PhD^1,2*, Miso Park^3*, Yinghui Zhu^4,5*, Enrico Caserta^2,6*, Ottavio Napolitano^2,6*, Theophilus Tandoh^2,6*, Milad Moloudizargari^2,6*, Alexander Pozhitkov^2,6*, Mahmoud Singer, PhD^7*, Ada Alice Dona^2,6*, Hawa Vahed^8*, Asaul Gonzalez, Gonzalez^9*, Kevin Ly^10*, Ching Ouyang^11*, James Sanchez^6*, Lokesh Nigam^2,6*, Arnab Chowdhury^6*, Lucy Y. Ghoda, PhD^12,13*, Ling Li, PhD⁵, Bin Zhang^13,14*, Amrita Krishnan, MD¹⁵, Guido Marcucci, MD^13,16,17, John C. Williams^3* and Flavia Pichiorri^2,6

¹Judy and Bernard Briskin Center for Multiple Myeloma Research, City of Hope, Los Angeles, CA
²Department of Hematologic Malignancies Translational Science, City of Hope, Monrovia, CA
³Department of Cancer Biology and Molecular Medicine, Beckman Research Institute, City of Hope, Duarte, CA
⁴TONFJI UNIVERSITY, SHANGHAI, China
⁵Department of Hematological Malignancies Translational Science, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA
⁶Judy and Bernard Briskin Center for Multiple Myeloma Research, City of Hope, Duarte, CA
⁷UCI, Irvine, CA
⁸City of Hope, Duarte, CA
⁹Beckman Research Institute, Department of Cancer Biology and Molecular Medicine,, Duarte, CA
¹⁰Department of Cancer Biology and Molecular Medicine, Beckman Research Institute, Duarte, CA
¹¹Integrative Genomics Core, City of Hope Comprehensive Cancer Center, City of Hope;, Duarte, CA
¹²Department of Hematologic Malignancies Translational Science, City of Hope, Duarte, CA
¹³Department of Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA
¹⁴Department of Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA
¹⁵Judy and Bernard Briskin Center for Multiple Myeloma Research, City of Hope, Irvine, CA
¹⁶Department of Hematological Malignancies Translational Science, Gehr Family Center for Leukemia Research, Hematologic Malignancies and Stem Cell Transplantation Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA
¹⁷Hematology/HCT, City of Hope National Medical Center, Duarte, CA

Manja Wobus^1*, Heike Weidner, PhD^2*, Kristin Möbus^3*, Anna-Lena Baumann^3*, Ivonne Habermann^3*, Tolga Danismaz^3*, Ekaterina Balaian, MD^3*, Marie Törngren, PhD^4*, Helena Eriksson, PhD^5*, Eva Bondesson^6*, Martina Rauner^7*, Martin Bornhaeuser, MD⁸ and Katja Sockel, MD^8*

¹Department of Internal Medicine I, University Hospital, TU Dresden, Dresden, Germany
²Department of Medicine III & Center for Healthy Aging, University Hospital TU Dresden, Dresden, Germany
³Department of Medicine I, University Hospital TU Dresden, Dresden, Germany
⁴Active Biotech, Lund, Sweden
⁵Active Biotech AB, Lund, SWE
⁶Active Biotech AB, Lund, AL, SWE
⁷University Hospital TU Dresden, Dresden, Germany
⁸Department of Internal Medicine I, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany

Bo-Reum Kim^1*, Hyunseok Kang^2*, Yoon-Ju Kim^1*, Hyunsong Son^1*, Jisu Park^3*, Yuna Park^3*, Heeje Kim, MD, PhD⁴, Hyunsun Jo^3* and Byoung Sik Cho^4*

¹The Catholic University of Korea, Seoul, KOR
²University of California San Francisco, San Francisco
³PIN Therapeutics, Seoul, Korea, Republic of (South)
⁴Department of Hematology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)

Noemi Angelosanto, MD¹, Ewa Lech Marańda, Prof^2*, Jan Maciej Zaucha, Prof^3*, Camille N. Abboud, MD⁴, Agnieszka Sroka-Porada^5*, Wiktoria Ogrodzińska, MSc^5*, Magdalena Kozakowska, PhD^5*, Urszula Głowniak-Kwitek, MSc^5*, Karolina Bukowska-Strakova, PhD^6*, Tomasz Rzymski, PhD^5*, Milena Mazan, PhD^7*, Urszula Pakulska, PhD^5*, Kristina Göller, BSc^5*, Ewa Zarzycka, MD^8* and Hendrik Nogai, MD^5*

¹Ryvu Therapeutics, Buccinasco, Italy
²Institute of Hematology and Transfusion Medicine, Warszawa, Poland
³Department of Haematology and Transplantology, Medical University of Gdańsk, Gdańsk, Poland
⁴Washington University School of Medicine, Saint Louis, MO
⁵Ryvu Therapeutics, Kraków, Poland
⁶University Children’s Hospital of Cracow, Kraków, Poland
⁷Ryvu Therapeutics, Krakow, AL, Poland
⁸Department of Hematology and Transplantology, Medical University of Gdansk, Gdansk, Poland

Hooman Izadi^1*, Hui Wang^1*, Christian Atsriku^2*, Zef Konst^2*, Adam Levinson^2*, Joseph Piccotti, PhD^1*, Steven Pirie-Shepherd, PhD^1*, Lin Tang^1*, Dan Weiss^2*, Karen Akinsanya^2*, Hamish Wright² and Kristian K Jensen, PhD^2*

¹Schrödinger, Inc., San Diego
²Schrödinger, Inc., New York, NY

Franziska Wachter, MD¹, Radoslaw Nowak, PhD^2,3* and Eric Fischer, Ph.D.^4,5*

¹Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA
²Cancer Biology, Dana-Farber Cancer Institute, Boston, MA
³Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston
⁴Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA
⁵Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA

Hiroyoshi Kunimoto, MD¹, Ayaka Miura, BS^1*, Maiko Sagisaka^2*, Mieko Ito^2*, Daisuke Honma, PhD^3*, Shinji Tsutsumi, PhD^4*, Takayuki Sakuma, MD^1*, Takuma Ohashi, MD^1*, Hiroshi Teranaka, MD^1*, Junji Ikeda, MD^1*, Takashi Toya, MD, PhD^5*, Yuka Harada, MD, PhD⁶, Noriko Doki, MD, PhD⁵, Sheng F. Cai, MD, PhD^7,8*, Akihide Yoshimi, MD, PhD⁹, Hiroaki Goto, MD, PhD^2*, Ross L Levine, MD^8,10 and Hideaki Nakajima, MD, PhD¹

¹Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan
²Clinical Research Institute, Kanagawa Children's Medical Center, Yokohama, Japan
³Discovery Intelligence Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, Japan
⁴Daiichi Sankyo Co., Ltd., Tokyo, Japan
⁵Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
⁶Clinical Research Support Center, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
⁷Leukemia Service, Department of Medicine, Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY
⁸Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY
⁹Division of Cancer RNA Research, National Cancer Center Research Institute, Tokyo, Japan
¹⁰Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY

Hiroki Akiyama, MD, PhD¹, Matthew Tcheng, BSc^2*, Priyanka Sharma, PhD¹, Ran Zhao, MS^1*, Lauren B. Ostermann, BSc^1*, Samar Yazdani^1*, Arman Moayed^1*, Zdzislaw Szulc^3*, Natalia Oleinik^3*, Po Yee Mak^1*, Vivian Ruvolo^1*, Bing Z. Carter, PhD¹, Besim Ogretmen, PhD^3*, Gautam Borthakur, MD⁴, Aaron D. Schimmer, MD², Michael Andreeff, MD PhD⁴ and Jo Ishizawa, MD, PhD⁴

¹Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²University Health Network, Princess Margaret Cancer Centre, Toronto, ON, Canada
³Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC
⁴Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX

Kentson Lam, MD, PhD, BA¹, Yoon Joon Kim^2*, Carlo M. Ong^2*, Andrea Liu^2*, Bernadette Chua, PhD^2*, Jie-Hua Zhou^3*, Edward D. Ball, MD³ and Robert Signer, PhD⁴

¹Division of Regenerative Medicine, Department of Medicine, Sanford Stem Cell Institute, Moores Cancer Center, University of California, San Diego, San Diego, CA
²Division of Regenerative Medicine, Department of Medicine, Sanford Stem Cell Institute, Moores Cancer Center, University of California, San Diego, La Jolla, CA
³Division of Bone and Marrow Transplantation, Department of Medicine, Moores Cancer Center, University of California, San Diego, La Jolla, CA
⁴University of California San Diego, Moores Cancer Center, La Jolla, CA

Yael Morgenstern^1*, JongBok Lee^2*, Yoosu Na^2*, William Gwynne^3*, Rose Hurren^1*, Li Ma^1*, Marcela Gronda^4*, Chaitra Sarathy, PhD^1*, Arvind Mer^1*, Andrea Arruda^5*, Avraham Frisch, MD^6*, Tsila Zuckerman^7*, Yishai Ofran, MD^8,9, Mark D. Minden^10*, Li Zhang^2*, Catherine O'Brien^1*, J. Rafael Montenegro-Burke^3* and Aaron D. Schimmer, MD¹

¹University Health Network, Princess Margaret Cancer Centre, Toronto, ON, Canada
²Department of immunology, University of Toronto, Toronto, Canada
³Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada
⁴UHN, Princess Margaret Cancer Centre, Toronto, ON, Canada
⁵Princess Margaret Cancer Centre, University Health Network, Toronto, Canada
⁶Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, Rappaport Faculty of Medicine - Technion, Haifa, Israel
⁷Department of Hematology and BMT, Rambam Health Care Campus, Haifa, Israel
⁸Department of Hematology and Bone Marrow Transplant, Sharee Zedek Medical Center, Jerusalem, Israel
⁹Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
¹⁰Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada

Yanxia Shi, PhD^1*, Qian Jiang, MD², Linxin Li, DPhil^1*, Shuzhen Jiang^1*, Tingting Yan^1*, Cuifang Zheng^1*, Yixin Ai^3* and Yihan Wang, PhD^4*

¹Department of Biological Research, Shenzhen TargetRx, Inc., Shenzhen, China
²Peking University People’s Hospital,Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing, China
³Department of Computational Chemistry, Shenzhen TargetRx, Inc., Shenzhen, China
⁴Shenzhen TargetRx, Inc., Shenzhen, China