Moritz Furstenau, MD^1*, Adam Giza^2*, Christof Schneider, MD^3*, Eugen Tausch, MD^4*, Sandra Robrecht, PhD^2*, Matthias Ritgen^5*, Jörg Bittenbring, MD^6*, Holger F. Hebart, MD⁷, Björn Schöttker^8*, Anna Lena Illert^9*, Ullrich Graeven, MD^10*, Andrea Stoltefuss, MD^11*, Bernhard Heinrich^12*, Robert Eckert, MD¹³, Anna-Maria Fink, MD^2*, Janina Stumpf^2*, Florian Simon, MD^14*, Kirsten Fischer, MD^2*, Othman Al-Sawaf, MD², Petra Langerbeins^15*, Fanni Kleinert^16*, Jonathan Weiss^16*, Karl-Anton Kreuzer^14*, Anke Schilhabel^17*, Monika Brüggemann, MD^18*, Barbara F. Eichhorst, MD¹⁹, Stephan Stilgenbauer, MD⁴, Michael Hallek, MD^20* and Paula Cramer, MD^2*

¹Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf; German CLL Study Group, University of Cologne, Koeln, Germany
²Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf; German CLL Study Group, University of Cologne, Cologne, Germany
³Division of CLL, Department of Internal Medicine III, University of Ulm, Ulm, Germany
⁴Department of Internal Medicine III, Division of CLL, Ulm University, Ulm, Germany
⁵Department II of Internal Medicine, University of Schleswig-Holstein, Kiel, Germany
⁶4Department of Internal Medicine 1 (Oncology, Hematology, Clinical Immunology, and Rheumatology), Saarland University Medical School, Homburg, Homburg, DEU
⁷Stauferklinikum, Mutlangen, Mutlangen, DEU
⁸Hämatologisch-onkologische Schwerpunktpraxis Würzburg, Würzburg, Germany
⁹7Department of Medicine III, Technical University of Munich, School of Medicine, Munich, Germany
¹⁰Department of Hematology, Oncology and Gastroenterology, Medical Clinic I, Hospital Maria Hilf GmbH, Mönchengladbach, Germany, Mönchengladbach, DEU
¹¹Evangelisches Krankenhaus, Hamm, DEU
¹²Hämatologisch-onkologische Praxis Heinrich/Bangerter, Augsburg, Augsburg, Germany
¹³Onkologische Schwerpunktpraxis, Esslingen, DEU
¹⁴Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf; German CLL Study Group, University of Cologne, Cologne, Cologne, DEU
¹⁵Department I of Internal Medicine and Center of Integrated Oncology Aachen, Bonn, Cologne, Duesseldorf; Cologne, University of Cologne, Cologne, Germany
¹⁶Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf; German CLL Study Group, University of Cologne, Cologne, Cologne, Germany
¹⁷2nd Department of Internal Medicine, University of Schleswig-Holstein, Campus Ki, Kiel, DEU
¹⁸Clinic for Internal Medicine II - Haematology, Oncology, University Clinic Schleswig-Holstein, Kiel, Germany
¹⁹University of Cologne, Cologne, Germany
²⁰Faculty of Medicine and Cologne University Hospital, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, University of Cologne, Cologne, Germany, Cologne, Germany

Rosemary Anne Harrup^1*, Arnon P. Kater, MD, PhD², Barbara F. Eichhorst, MD³, Carolyn Owen, MD⁴, Brenda Chyla⁵, Hyun Yong Jin, PhD^6*, Yanwen Jiang, PhD^6*, Yi Meng Chang, MSc^7*, Rosemary Millen, PhD^7*, Marcus Lefebure, PhD, BSc^7*, Maria Thadani-Mulero, PhD^7*, Michelle Boyer, PhD, BA^7* and John F. Seymour, MBBS, PhD, FRACP⁸

¹Royal Hobart Hospital, University of Tasmania, Tasmania, Australia
²Amsterdam University Medical Centers, Amsterdam, Netherlands
³University of Cologne, Cologne, Germany
⁴University of Calgary, Calgary, AB, Canada
⁵AbbVie Inc, North Chicago, IL
⁶Genentech, Inc., South San Francisco, CA
⁷Roche Products Ltd, Welwyn Garden City, United Kingdom
⁸Peter MacCallum Cancer Center, Royal Melbourne Hospital and University of Melbourne, Melbourne, VIC, Australia

Kerry A Rogers, MD¹, Eric McLaughlin, MS^2*, Lai Wei, PhD^2*, Seema A Bhat, MD¹, Arianna Crouse, PhD^3*, Michael R. Grever, MD¹, Dan Jones, MD⁴, Adam S Kittai, MD¹, Gerard Lozanski, MD^4*, Mollie Moran, CNP^3*, Mark Reid, CNP^3*, Ellen J Sass, BS^1*, Swetha Suresh, CNP^3*, John C. Byrd, MD⁵ and Jennifer A. Woyach, MD¹

¹Division of Hematology, The Ohio State University, Columbus, OH
²Center for Biostatistics, The Ohio State University, Columbus, OH
³Comprehensive Cancer Center, The Ohio State University, Columbus, OH
⁴Department of Pathology, The Ohio State University, Columbus, OH
⁵Department of Internal Medicine, University of Cincinnati, Cincinnati, OH

Keshu Zhou, MD^1*, Mingyuan Sun^2*, Xu Wei, MD, PhD³, Shuhua Yi^2*, Junyuan Qi, MD^2*, Weiqi Nian^4*, Guohui Cui^5*, Jishi Wang, PhD⁶, Xiaoping Zhang^7*, Hong Cen^8*, Fuling Zhou, PhD⁹, Jianying Huang^10*, Huilan Liu^11*, Aizong Shen^11*, Liangquan Geng^11*, Ru Feng^12*, Chongyuan Xu^12*, Wenbin Qian^13*, Fei Li^14*, Lihong Liu^15*, Caixia Li^16*, Xielan Zhao^17*, Jie Jin¹⁸, Hongmei Jing¹⁹, Dongmei Ji^20*, Fangfang Lyu^20*, Zi Chen^21*, Lichuang Men^21*, Hengbang Wang^21*, Ke Zhang^21*, Liang Xu^21*, Zhang Zhang^22*, Dajun Yang^23,24*, Jianxiang Wang, MD², Jianyong Li, MD²⁵ and Yifan Zhai^23,26

¹Department of Hematology, Henan Cancer Hospital, Zhengzhou, China
²State Key Laboratory of Experimental Hematology, National Clinical Research Center for Hematologic Disorders, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
³Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing City, Jiangsu Province, China
⁴Chongqing Cancer Hospital, Chongqing, China
⁵Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⁶Department of Hematology, Affiliated Hospital of Guizhou Medical University, Guiyang City, China
⁷Zhongda Hospital affiliated to Southeast University, Nanjing, China
⁸Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China
⁹Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China
¹⁰Zhongnan Hospital of Wuhan University, Wuhan, China
¹¹First Affiliated Hospital of University of Science and Technology of China (USTC) Anhui Provincial Hospital, Hefei, China
¹²Nanfang Hospital, Southern Medical University, Guangzhou, China
¹³Department of Hematology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
¹⁴First Affiliated Hospital of Nanchang University, Nanchang, China
¹⁵The Fourth Hospital of Hebei Medical University, Shijiazhuang, China
¹⁶The First Affiliated Hospital of Soochow University, Suzhou, China
¹⁷Xiangya Hospital Central South University, Changsha, China
¹⁸The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
¹⁹Peking University Third Hospital, Beijing, China
²⁰Fudan University Shanghai Cancer Center, Shanghai, China
²¹Ascentage Pharma (Suzhou) Co., Ltd., Suzhou, China
²²Ascentage Pharma Group, Inc., Rockville, MD
²³Ascentage Pharma Group Inc., Rockville, MD
²⁴Department of Experimental Research, State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China
²⁵Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing, China
²⁶State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China

Florian Simon, MD^1*, Rudy Ligtvoet, PhD^2*, Sandra Robrecht, PhD^2*, Paula Cramer, MD^2*, Nadine Kutsch, MD^2*, Moritz Fürstenau, MD^3*, Valentin Goede, MD^2,4*, Julia Von Tresckow, MD^5*, Petra Langerbeins^2*, Anna-Maria Fink, MD^2*, Henriette Huber, MD^6*, Eugen Tausch, MD^7*, Christof Schneider, MD^8*, Clemens-Martin Wendtner, MD^9*, Matthias Ritgen^10*, Martin Dreyling, MD¹¹, Lothar Müller^12*, Lutz Jacobasch, MD^13*, Werner Heinz, MD^14*, Ursula Vehling-Kaiser, MD^15*, Liliya Sivcheva, MD^16*, Sebastian Böttcher^17*, Peter Dreger, MD¹⁸, Thomas Illmer, MD^19*, Michael Gregor^20*, Philipp Bernhard Staber, MD, PhD²¹, Stephan Stilgenbauer, MD⁷, Carsten Utoft Niemann, MD, PhD^22*, Arnon P. Kater, MD, PhD²³, Kirsten Fischer, MD^2*, Barbara F. Eichhorst, MD²⁴, Michael Hallek, MD^25* and Othman Al-Sawaf, MD²

¹Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf; German CLL Study Group, University of Cologne, Cologne, AL, Germany
²Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf; German CLL Study Group, University of Cologne, Cologne, Germany
³Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf; German CLL Study Group, University of Cologne, Koeln, Germany
⁴St. Marienhospital Cologne, Oncogeriatric Unit, Department of Geriatric Medicine, Cologne, Germany
⁵Clinic for Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
⁶Städtisches Klinikum Karlsruhe, Karlsruhe, Germany
⁷Department of Internal Medicine III, Division of CLL, Ulm University, Ulm, Germany
⁸Division of CLL, Department of Internal Medicine III, University of Ulm, Ulm, Germany
⁹Department of Hematology, Oncology, Immunology, Palliative Care, Infectious Diseases and Tropical Medicine, German CLL Study Group, Munich Clinic Schwabing, Munich, Germany
¹⁰Department II of Internal Medicine, University of Schleswig-Holstein, Kiel, Germany
¹¹Department of Medicine, Medical Clinic III, Ludwig-Maximilians-University Hospital, Munich, Germany
¹²Study Centrum Unter Ems, Practice for Oncology and Hematology, Leer, Germany
¹³Praxis of Haematology and Oncology, Dresden, Germany
¹⁴Caritas-Krankenhaus Bad Mergentheim, Medizinische Klinik II, Bad Mergentheim, Germany
¹⁵Outpatient Clinic, Landshut, Germany
¹⁶First Department of Internal Medicine, Multiprofile Hospital for Active Treatment - HristoBotev, Vratsa, Bulgaria
¹⁷Department of Medicine III Hematology, Oncology and Palliative Care, University Hospital, Rostock, Germany
¹⁸Department of Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany
¹⁹Hematology Private Practice, Dresden, Germany
²⁰Division of Hematology, Cantonal Hospital of Lucerne, Lucerne, Switzerland, Luzern, Switzerland
²¹Department of Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna, Vienna, Austria
²²Department of Hematology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
²³Academic Medical Center, Amsterdam Zuidoost, NH, Netherlands
²⁴University of Cologne, Cologne, Germany
²⁵Faculty of Medicine and Cologne University Hospital, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, University of Cologne, Cologne, Germany, Cologne, Germany

Vanitha Ramakrishnan, PhD^1*, Linlin Xu, PhD^1*, Jason C. Paik, MD, PhD¹, Carol Marimpietri, RN, MS^1*, Eric Shen, BS^2*, Xiaoxi Dong, PhD^2*, Jessica Li, MSc^1*, Andreas Agathangelidis^3*, Tian Tian, PhD^1*, Aileen Cleary Cohen, MD, PhD¹, Tadeusz Robak^4*, Constantine S. Tam, MD, MBBS⁵, Paolo Ghia, MD, PhD⁶, Andrew Rawstron, PhD^7* and Jennifer R. Brown, MD, PhD⁸

¹BeiGene USA, Inc, San Mateo, CA
²Predicine, Inc., Hayward, CA
³School of Biology, National and Kapodistrian University of Athens, Athens, Greece
⁴Medical University of Lodz, Lodz, Poland
⁵Alfred Hospital and University of Melbourne, Melbourne, VIC, Australia
⁶Vita-Salute San Raffaele University, Milan, Italy
⁷Haematological Malignancy Diagnostic Service, Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
⁸Chronic Lymphocytic Leukemia Center, Division of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA

Deyan Y. Yosifov, PhD^1,2*, Sandra Robrecht, PhD^3*, Adam Giza^3*, Armin Riecke^4*, Christof Schneider, MD^5*, Billy Jebaraj, PhD^6*, Hassan Jumaa, PhD^7*, Marc Young^8*, Lothar Müller^9*, Ursula Vehling-Kaiser, MD^10*, Michael J. Eckart, MD^11*, Werner Freier^12*, Björn Schöttker^13*, Tobias Gaska, MD¹⁴, Marcel Reiser^15*, Anna-Maria Fink, MD^3*, Kirsten Fischer, MD^3*, Barbara F. Eichhorst, MD¹⁶, Michael Hallek, MD^17*, Petra Langerbeins^3*, Stephan Stilgenbauer, MD⁶ and Eugen Tausch, MD^18*

¹Department of Internal Medicine III, Division of CLL, Ulm University, Ulm, Baden-Württemberg, Germany
²German Cancer Research Center (DKFZ), Heidelberg, Germany
³Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf; German CLL Study Group, University of Cologne, Cologne, Germany
⁴Internal Medicine, Division of Hematology, German Military Hospital Ulm, Ulm, Germany
⁵Division of CLL, Department of Internal Medicine III, University of Ulm, Ulm, Germany
⁶Department of Internal Medicine III, Division of CLL, University Hospital Ulm, Ulm, Germany
⁷Institute of Immunology, University Hospital of Ulm, Ulm, Germany
⁸Institute of Immunology, Ulm University, Ulm, Germany
⁹Study Centrum Unter Ems, Practice for Oncology and Hematology, Leer, Germany
¹⁰Outpatient Clinic, Landshut, Germany
¹¹Onkologische Schwerpunktpraxis Erlangen, Erlangen, Germany
¹²Medicinum, Hildesheim, Germany
¹³Hämatologisch-onkologische Schwerpunktpraxis Würzburg, Würzburg, Germany
¹⁴Brüderkrankenhaus St. Josef, Paderborn, Germany
¹⁵Klinik I für Innere Medizin, Cologne, Germany
¹⁶University of Cologne, Cologne, Germany
¹⁷Faculty of Medicine and Cologne University Hospital, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, University of Cologne, Cologne, Germany, Cologne, Germany
¹⁸Department of Internal Medicine III, Division of CLL, Ulm University, Ulm, Germany

Piers Patten, FRCP, FRCPath, PhD¹, Jonathan Cook, PhD^2*, Nicholas Peckham, PhD^3*, Paul Moss, PhD, MBBS, FRCP^4*, Neil Phillips, MBBS, FRCPath, MRCP^5*, Abhishek Abhishek, MBChB PhD^6*, Thomas Roberts, MSc^7*, Georgina Talbot, MBChB^8*, Vicki Barber, PhD^9*, Anne Francis, PhD^10*, Fiona Ashford, MSc^7*, Lelia Duley^11*, Robbert Hoogeboom, PhD^12*, Brian Willett, PhD^13*, Nilima Parry-Jones, MD, MBBS, FRCP, FRCPath¹⁴, Toby A. Eyre^15*, Farooq Ahmad Wandroo, MD, FRCPath, FRCP^16*, Claire Hutchinson, MBCh, FRCPath, PhD^17*, Duncan James Murray, FRCPath, MRCP, MA, BMBS^18*, Gratian Vandici^19*, Nicolas Martinez-Calle^20*, Stephen Jenkins, MBChB^21* and Helen M Parry, MBChB, MRCP, FRCPath, PhD^22,23

¹King’s College London, London, GBR
²Oxford Clinical Trials Unit, University of Oxford, Oxford, United Kingdom
³Oxford Clinical Trials Research Unit, University of Oxford, Oxford, United Kingdom
⁴University of Birmingham, Birmingham, GBR
⁵University Hospitals of North Midlands NHS Trust, Stoke on Trent, United Kingdom
⁶University of Nottingham, Nottingham, United Kingdom
⁷University of Birmingham, Birmingham, United Kingdom
⁸University Hospitals of North Midlands NHS Trust, Stoke On Trent, GBR
⁹Oxford University Trials Research Unit, University of Oxford, Oxford, United Kingdom
¹⁰University of Oxford, Oxford, United Kingdom
¹¹CLL Support Association, London, United Kingdom
¹²Kings College London, London, United Kingdom
¹³University of Glasgow, Glasgow, United Kingdom
¹⁴Aneurin Bevan University Hospital Board, Abergavenny, WAL, GBR
¹⁵Oxford University Hospitals NHS Foundation Trust, Churchill Cancer Center, Oxford, United Kingdom
¹⁶Sandwell & West Birmingham Hospitals, NHS Trust, West Bromwich, GBR
¹⁷Plymouth Hospitals NHS Trust, Plymouth, GBR
¹⁸University Hospitals Coventry and Warwickshire, Birmingham, ENG, GBR
¹⁹Oxford Clinical Trials Research Group, University of Oxford, Oxford, United Kingdom
²⁰Haematology, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom
²¹The Dudley Group NHS Foundation Trust, Birmingham, United Kingdom
²²Department of Haematology and Stem Cell Transplantation, University Hospitals Birmingham, Birmingham, United Kingdom
²³Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, GBR

Francesca Romana Mauro^1*, Irene Della Starza, PhD^1*, Monica Messina, PhD^2*, Gianluigi Reda, MD^3*, Livio Trentin⁴, Marta Coscia, MD, PhD^5*, Paolo Sportoletti, MD^6*, Lorella Orsucci, MD^7*, Valentina Arena, MS^2*, Gianluca Gaidano, MD, PhD⁸, Roberto Marasca, MD⁹, Roberta Murru, MD^10*, Luca Laurenti, MD^11*, Caterina Stelitano^12*, Donato Mannina, MD^13*, Fiorella Ilariucci, MD^14*, Massimo Massaia¹⁵, Gian Matteo Rigolin, MD^16*, Lydia Scarfo, MD¹⁷, Monia Marchetti, MD^18*, Luciano Levato, MD^19*, Monica Tani^20*, Annalisa Arcari, MD^21*, Gerardo Musuraca, MD, PhD^22*, Marina Deodato, MD^23*, Piero Galieni, MD^24*, Valeria Belsito Patrizi, MD^25*, Daniela Gottardi, MD^26*, Anna Marina Liberati, MD²⁷, Annamaria Giordano, MD^28*, Maria Chiara Molinari, MD^1*, Sara Pepe, MD, PhD^1*, Costanza Andriola, MD^1*, Veronica Mattiello, MD^3*, Andrea Visentin, MD, PhD^29*, Candida Vitale, MD, PhD^5*, Francesco Albano, MD^28*, Antonino Neri, MD^3*, Maria Stefania De Propris, MD, PhD^30*, Mauro Nanni, PhD^1*, Ilaria Del Giudice^31*, Anna Guarini, PhD^30*, Paola Fazi, MD^2*, Marco Vignetti, MD^32*, Alfonso Piciocchi, MS^2*, Antonio Cuneo, MD^16* and Robin Foà, MD^30*

¹Hematology, Department of Translational and Precision Medicine, Sapienza University, Rome, Italy
²GIMEMA Foundation, Data Center and Health Outcomes Research Unit, Rome, Italy
³Hematology Department, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico of Milan, Milan, Italy
⁴Hematology Unit, Department of Medicine, University of Padua, Padua, Italy
⁵Division of Hematology, A.O.U. Città della Salute e della Scienza di Torino and Department of Molecular Biotechnology and Health Sciences, University of Torino, Turin, Italy
⁶Department of Medicine and Surgery, Institute of Hematology, Centro di Ricerca Emato-Oncologica (CREO), University of Perugia, Perugia, Italy
⁷Hematology Division, A.O.U Città della Salute e della Scienza, Ospedale S. Giovanni Battista Molinette, Torino, Italy
⁸Division of Hematology, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy
⁹Hematology Unit and Chair, Department of Medical and Surgical Sciences, Azienda Ospedaliera Universitaria di Modena, University of Modena and Reggio Emilia, Modena, Italy
¹⁰Hematology and Stem Cell Transplantation Unit, Ospedale Oncologico A. Businco, ARNAS "G. Brotzu", Cagliari, Italy
¹¹Division of Hematology, Fondazione Universitaria Policlinico A Gemelli di Roma, Rome, Italy
¹²Department of Hematology, Azienda Ospedaliera Bianchi Melacrinò Morelli, Reggio Calabria, Reggio Calabria, Italy
¹³Division of Hematology, Azienda Ospedaliera Papardo, Messina, Messina, Italy
¹⁴Hematology Azienda USL - IRCCS Reggio Emilia, Reggio Emilia, Italy
¹⁵Division of Hematology, Santa Croce e Carle Hospital, Cuneo, Italy
¹⁶Hematology Section, St. Anna University Hospital, Ferrara, Italy
¹⁷Strategic Research program on CLL, Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Milano, Italy
¹⁸Hematology Unit, AO Santi Antonio e Biagio e Cesare Arrigo, Alessandria, Italy
¹⁹Department of Hematology, Pugliese Ciaccio Hospital, Catanzaro, Italy
²⁰Division of Hematology, Santa Maria delle Croci Hospital, Ravenna, Italy
²¹Division of Hematology, Guglielmo da Saliceto Hospital, Piacenza, Italy
²²Hematology Unit, Istituto Scientifico Romagnoli per lo Studio e la Cura dei Tumori-IRST, Meldola, Italy
²³Department of Hematology, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy
²⁴UOC Ematologia Ospedale Mazzoni, Ascoli Piceno, Italy
²⁵Hematology Department, Umberto I Hospital, Nocera Inferiore, Italy
²⁶University Division of Hematology and Cellular Therapy, A.O. Ordine Mauriziano, TORINO, ITA
²⁷Università degli Studi di Perugia, Azienda Ospedaliera Santa Maria di Terni, Terni, Italy
²⁸Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), Hematology and Stem Cell Transplantation Unit, University of Bari "Aldo Moro", Bari, Italy
²⁹Hematology and Clinical Immunology Unit, Department of Medicine, University of Padua, Padua, Italy
³⁰Division of Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
³¹Hematology, Department of Translational and Precision Medicine, Sapienza University, Roma, Italy
³²GIMEMA Foundation, Rome, Italy

Cecelia Miller, PhD^1*, Ying Huang, MS, MA², Adam S Kittai, MD², Seema A Bhat, MD², Kerry A Rogers, MD², Michael R. Grever, MD², Jennifer A. Woyach, MD² and Matthew R Avenarius, PhD^3*

¹The Ohio State University Comprehensive Cancer Center, Columbus, OH
²Division of Hematology, The Ohio State University, Columbus, OH
³The Ohio State University, Columbus, OH

Benjamin M. Heyman, MD¹, Michael Y. Choi, MD¹ and Thomas J. Kipps, MD, PhD²

¹Moores Cancer Center, University of California San Diego, La Jolla, CA
²Center for Novel Therapeutics, University of California, San Diego Moores Cancer Center, La Jolla, CA

Nilanjan Ghosh, MD, PhD¹, Nicole Lamanna, MD^2*, Toby A. Eyre^3*, Catherine C Coombs, MD^4*, Beenish S Manzoor, PhD, MPH^5*, Jennifer R. Brown, MD, PhD⁶, Hande H. Tuncer, MD⁶, Chaitra S Ujjani, MD⁷, Lori A Leslie^8*, Lindsey E. Roeker, MD⁹, Matthew S. Davids, MD, MMSc⁶, Joanna M. Rhodes, MD, MSCE^10*, Alan Skarbnik, MD¹¹, Nnadozie Emechebe^5*, Isabelle Fleury, MD¹², Brian T. Hill, MD¹³, Christopher P. Fox, MD, PhD¹⁴, Paul M. Barr, MD¹⁵, Dureshahwar Jawaid^5*, Wendy J Sinai, PharmD^5*, Laurie K Pearson, MD^16*, Frederick Lansigan, MD^17*, Yun Choi^18*, Christopher E. Jensen^19*, Stephen J. Schuster, MD²⁰, Kaitlin Kennard^20*, Irina Pivneva, PhD^21*, Talissa Watson^21*, Annie Guerin^21* and Mazyar Shadman, MD, MPH²²

¹Levine Cancer Institute/Atrium Health, Charlotte, NC
²Columbia University, New York, NY
³Churchill Hospital, Oxford University, Oxford, United Kingdom
⁴University of California Irvine, Irvine, CA
⁵AbbVie, Inc., North Chicago, IL
⁶Dana-Farber Cancer Institute, Boston, MA
⁷Fred Hutchinson Cancer Research Center, Seattle, WA
⁸John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, NJ
⁹CLL Program, Leukemia Service, Division of Hematologic Oncology, Memorial Sloan Kettering Cancer Center, New York, NY
¹⁰Rutgers Cancer Institute of New Jersey, New Brunswick, NJ
¹¹Novant Health Cancer Institute, Lymphoma and CLL Program, Charlotte, NC
¹²Hôpital Maisonneuve-Rosemont, University of Montreal, Montreal, Canada
¹³Cleveland Clinic, Cleveland, OH
¹⁴School of Medicine, University of Nottingham, Nottingham, United Kingdom
¹⁵Wilmot Cancer Institute, University of Rochester, Rochester, NY
¹⁶University of Massachusetts, Worcester, MA
¹⁷Dartmouth-Hitchcock Medical Center, Lebanon, NH
¹⁸Tufts Medical Center, Boston, MA
¹⁹Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
²⁰University of Pennsylvania, Philadelphia, PA
²¹Analysis Group, Inc., Montreal, Canada
²²Fred Hutchinson Cancer Center, Seattle, WA

Vincent Levy, MD, PhD^1*, Tushar Srivastava^2*, Keri Yang, PhD, MBA, MPH, MS, CPM, BSPharm^3*, Palash Purkayastha^4*, Raju Gautam^2*, Kaijun Wang^3* and Leyla Mohseninejad, PhD^5*

¹Hôpital Avicenne, AP-HP et Université Sorbonne, Paris, France
²ConnectHEOR, London, United Kingdom
³BeiGene USA, Inc, San Mateo, CA
⁴ConnectHEOR, Delhi, India
⁵BeiGene Netherlands B.V., Schiphol, Netherlands

Kevin H. Lin, MD, PhD^1*, Lynn Huynh, DrPH, MBA, MPH^2*, Xiaoqin Yang, PhD^3*, Enrico Zanardo, PhD^4*, Lisa Matay, BA^2*, Megan Pinaire, MPH^2*, Daria Liborski, BS^1*, Mikaela M. McDonough, BS^1*, Jillian Foreman, BS^1*, Mohammed Z.H. Farooqui, DO³, Enrico De Nigris, MSc^5*, Shravanthi R. Gandra, PhD, MBA^3*, Eric M. Sarpong, PhD^3*, Mei Sheng Duh, RPh, MPH, ScD², Jennifer R. Brown, MD, PhD¹ and Matthew S. Davids, MD, MMSc¹

¹Dana-Farber Cancer Institute, Boston, MA
²Analysis Group, Inc., Boston, MA
³Merck & Co., Inc., Rahway, NJ
⁴Analysis Group, Denver, CO
⁵MSD, London, United Kingdom

Mohammad Ammad Ud Din, MBBS^1,2, Todd C Knepper, PharmD^1*, Julio C. Chavez, MD³, Lisa Nodzon, PhD¹, Hayder Saeed, MD¹, Sameh Gaballa, MD¹, Lubomir Sokol, MD, PhD⁴, Ning Dong, MD^4*, Leidy Lismeris Isenalumhe, MD, MS¹, Celeste M. Bello, MD⁴, Bijal D. Shah, MD⁵ and Javier Pinilla-Ibarz, MD, PhD^1*

¹H Lee Moffitt Cancer Center and Research Institute, Tampa, FL
²University of South Florida, Tampa, FL
³Moffitt Cancer Center, Tampa, FL
⁴Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL
⁵Moffitt Cancer Center and Research Institute, Tampa, FL

Heiko Mueller, PhD^*, Wencke Walter, PhD^*, Manja Meggendorfer, PhD, Stephan Hutter, PhD^*, Niroshan Nadarajah^*, Wolfgang Kern, MD, Torsten Haferlach, MD, PhD and Claudia Haferlach, MD

MLL Munich Leukemia Laboratory, Munich, Germany

Boyu Hu, MD¹, Brian Avery, PhD^2*, Rosalie Griffin, PhD³, Julie Feusier, PhD^4*, Ahmad Halwani, MD⁵, Justin Williams, MPH^5*, Brandt Jones, BS^5*, Michael Madsen, MStat^5*, Deborah M. Stephens, DO⁶ and Nicola J Camp, PhD^1*

¹Huntsman Cancer Institute, University of Utah, Salt Lake City, UT
²Huntsman Cancer Institute and School of Medicine, University of Utah, Salt Lake City, UT
³Mayo Clinic, Rochester, MN
⁴ARUP Laboratories, Salt Lake City, UT
⁵Huntsman Cancer Institute, Salt Lake City, UT
⁶Division of Hematology and Hematologic Malignancies, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT

Inhye E Ahn, MD, Yinglu Zhou, MS^*, Svitlana Tyekucheva, PhD^*, Hannah Cormier, BS^*, Stacey M Fernandes, BS^*, Josie Montegaard, NP^*, Marykate Kilcommons, RN^*, Jennifer L Crombie, MD, Reid W. Merryman, MD, Erin M Parry, MD, PhD, Philippe Armand, MD, PhD, David C Fisher, MD, Caron A Jacobson, MD, MMSc, Matthew S. Davids, MD, MMSc and Jennifer R. Brown, MD, PhD

Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA

Nilanjan Ghosh, MD¹, Zaina P Qureshi, PhD, MS, MPH^2*, Zhijie Ding, PhD^2*, Marie-Helene Lafeuille, MA^3*, Bruno Emond, MSc^3*, Priyanka Gogna, PhD^3*, Bronwyn Moore, BA^3*, Patrick Lefebvre, MA^3*, Alex Bokun, PharmD^2*, Heena Mavani, PharmD, MBA^2* and Kerry A Rogers, MD⁴

¹Atrium Health Levine Cancer Institute, Charlotte, NC
²Janssen Scientific Affairs, LLC, Horsham, PA
³Analysis Group, Inc, Montreal, QC, Canada
⁴Division of Hematology, The Ohio State University, Columbus, OH

Fausto Alfredo Rios Olais, MD¹, Alyssa K. McGary, MS^2*, Elena Juventina Tuna Aguilar, MD^3*, Diana Almader-Douglas, M.A., M.L.S.^2*, Mazie Tsang, MD⁴, Jose F. Leis, MD, PhD⁴, Matthew R. Buras, M.S^2* and Talal Hilal, MD⁴

¹Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, Mexico
²Mayo Clinic, Scottsdale, AZ
³Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
⁴Mayo Clinic, Phoenix, AZ

Alessandra Ferrajoli, MD¹, George Follows^2*, Yotvat Marmor^3*, Shogheeg Apkarian Bourjlian^4*, Jack Roos^4*, Naghmana Bajwa^4*, Venkata Madhira^5*, Kenji Nozaki^6*, Paulo Andre P. Palhares De Miranda, MD⁴ and Krish Patel, MD⁷

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Addenbrookes Hospital, Cambridge, United Kingdom
³AstraZeneca, South San Francisco, CA
⁴AstraZeneca, Gaithersburg, MD
⁵AstraZeneca, Wilmington, DE
⁶AstraZeneca, Osaka, Japan
⁷Swedish Cancer Institute, Seattle, WA

Henry Becerra, MD^1*, Nosakhare Paul Ilerhunmwuwa, MBBS, MSc¹, Mustafa Wasifuddin, MD^1*, Ifeanyi Nnamdi Uche, MBBS¹ and Jen-Chin Wang, MD^2*

¹Department of Medicine, Brookdale University Hospital and Medical Center, Brooklyn, NY
²Division of Hematology/Oncology, Brookdale University Hospital and Medical Center, Brooklyn, NY

Himil Mahadevia, MBBS¹, Ben Ponvilawan, MD^1* and Anuj Shrestha, MD²

¹Department of Internal Medicine, University of Missouri at Kansas City, Kansas City, MO
²Bloch Cancer Center / University Health at Truman Medical Center, University of Missouri At Kansas City, Overland Park, KS