65th ASH Annual Meeting & Exposition: 641. Chronic Lymphocytic Leukemias: Basic and Translational: Poster I

Symposia: Chronic Lymphocytic Leukemias: Basic and Translational Oral and Poster Abstracts
Poster

Halls G-H (San Diego Convention Center)

B-Cell Receptor Function and Gene Expression Profiling at Single-Cell Level across the Spectrum from Normal to Neoplastic CD5-Positive B-Cell Compartments in Humans

Edwin Quinten, BS¹^*, Julieta Sepulveda-Yanez, MSc²^*, Ramin Monajemi, MSc³^*, Roberta Menafra, PhD⁴^*, Susan L. Kloet, PhD⁴^*, Szymon M. Kiełbasa, PhD³^*, Cornelis A.M. van Bergen, PhD¹^* and Hendrik Veelken, MD, PhD ¹

¹Hematology, Leiden University Medical Center, Leiden, Netherlands
²Facultad de Ciencias de la Salud, Universidad de Magallanes, Punta Arenas, Chile
³Biological Data Sciences, Leiden University Medical Center, Leiden, Netherlands
⁴Human Genetics, Leiden University Medical Center, Leiden, Netherlands

1886

ZMYM3 Mutations Cooperate with NOTCH1 Alterations, Reduce Histone H4 Acetylation and Promote Apoptosis Evasion in Chronic Lymphocytic Leukemia

Alberto Rodríguez-Sánchez, PhD^1,2^*, Miguel Quijada Álamo, PhD^1,2^*, Claudia Perez Carretero, MSc, BSc^1,2^*, Luis Antonio Corchete Sanchez, PhD^3,4,5^*, Angela Villaverde Ramiro^2,6^*, Cristina Miguel-García^2,6^*, Sandra Santos-Mínguez^2,6^*, Julio Davila Valls⁷^*, Alfonso Garcia de Coca⁸^*, Julio Olazabal⁹^*, Maria Rocio Benito Sanchez, PhD^2,6^*, Ana E. Rodriguez, PhD^1,2^* and Jesús María Hernández-Rivas, PhD^1,2

¹University of Salamanca, IBSAL, IBMCC, CSIC, Cancer Research Center, Salamanca, Spain
²Department of Hematology, University Hospital of Salamanca, Salamanca, Spain
³Massachusetts General Hospital Center for Cancer Research, Charlestown
⁴Harvard Medical School, Boston
⁵Broad Institute of MIT and Harvard, Cambridge
⁶University of Salamanca, IBSAL, IBMCC, CSIC, Cancer Research Center, Department of Hematology - Hospital Universitario de Salamanca, Salamanca, Spain
⁷Department of Hematology, Nuestra Señora de Sonsoles Hospital, Ávila, Spain
⁸Department of Hematology, Clinical Hospital of Valladolid, Valladolid, Spain
⁹Department of Hematology, University Hospital of Burgos, Burgos, Spain

1887

Abbv-101, a Highly Potent and Selective Clinical Stage Bruton Tyrosine Kinase Degrader for the Treatment of B-Cell Malignancies

Chin Pan, PhD¹^*, Tarikere L Gururaja, PhD¹^*, Haiyan Li, MD, PhD, MPH¹^*, Henry Nguyen, PhD¹^*, Yongjiao Zhai¹^*, Xiaoping Xie, PhD¹^*, Rong-Xian Ding¹^*, Rebecca Mathew, PhD¹^*, Hana Y Hoh, MSc¹^*, Zhaozhong J Jia, PhD¹^*, Bo Liu, PhD¹^*, Cassandra Shu, PhD¹^*, Wissam Assaily, PhD¹^*, Lloyd T Lam, PhD²^*, Jacob J Riehm, MS²^*, Claudina Stevenson, PhD²^*, Christine Will, MS²^*, Federico Innocenti, MD, PhD¹ and Alexey Rivkin, PhD³^*

¹AbbVie Bay Area, South San Francisco, CA
²AbbVie Inc., North Chicago, IL
³AbbVie Bay Area, SAN FRANCISCO, CA

1888

Beyond CLL Progression: Unveiling Th17 and Th2 T Cell Subsets As Predictors of Pembrolizumab Response in Richter's Transformation

Prajish Iyer, PhD¹^*, Lu Yang, PhD²^*, Sutapa Sinha, PhD³^*, Miles Del Busso⁴^*, Zhi-Zhang Yang³^*, Hyojin Kim, PhD⁴^*, Charla Secreto⁴^*, Yucai Wang, MD, PhD³, Neil E. Kay, MD³, Stephen M Ansell, MD, PhD³, Wei Ding, MD, PhD⁵ and Lili Wang, MD/PhD⁶

¹Department of Systems Biology, Beckman Research Institute, City of Hope National Comprehensive Cancer, Monrovia, CA
²City of Hope Beckman Research Institute, Monrovia, CA
³Division of Hematology, Mayo Clinic, Rochester, MN
⁴Division of Hematology, Mayo Clinic, Rochester
⁵Mayo Clinic-Rochester, Rochester, MN
⁶Department of Systems Biology, City of Hope Comprehensive Cancer Center, Duarte, CA

1889

TRAF3-Inactivated Chronic Lymphocytic Leukemia Cells Show an Enhanced Metabolic Plasticity That Can be Attenuated By Glutaminolysis and Mitochondrial Pyruvate Import Inhibition

Claudia Perez Carretero, MSc, BSc^1,2^*, Miguel Quijada Álamo, PhD^1,2^*, Mariana Tannoury³^*, Léa Dehgane³^*, Alberto Rodríguez-Sánchez, PhD^1,2^*, Teresa González, PhD⁴^*, Maria Rocio Benito Sanchez, PhD^1,4^*, Elise Chapiro, MD, PhD⁵^*, Ana E. Rodriguez, PhD^1,2^*, Florence Nguyen-Khac, MD, PhD⁶^*, Santos A. Susin, MD, PhD⁷^* and Jesús María Hernández-Rivas, PhD^8,9,10

¹Department of Hematology, University Hospital of Salamanca, Salamanca, Spain
²University of Salamanca, IBSAL, IBMCC, CSIC, Cancer Research Center, Salamanca, Spain
³Sorbonne Université, Centre de Recherche des Cordeliers, UMRS 1138, INSERM, Paris, France
⁴University of Salamanca, IBSAL, IBMCC, CSIC, Cancer Research Center, Department of Hematology - Hospital Universitario de Salamanca, Salamanca, Spain
⁵Groupe Hospitalier Pitié-Salpêtrière, Paris, FRA
⁶Hôpital Pitié-Salpétrière, Paris, France, France
⁷Sorbonne Université, Centre de Recherche des Cordeliers, UMRS 1138, INSERM, Paris, FRA
⁸Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain
⁹Cancer Research Center of Salamanca (USAL-CSIC), Salamanca, Spain
¹⁰Department of Medicine, Hematology Department, Hospital Universitario de Salamanca, Salamanca, Spain

1890

Acquired Mutations in Patients (Pts) with Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia (CLL) That Progressed in the ALPINE Study

Jennifer R. Brown, MD, PhD¹, Jessica Li, MSc²^*, Barbara F. Eichhorst, MD³, Nicole Lamanna, MD⁴, Susan M. O'Brien⁵, Constantine S. Tam, MD, MBBS⁶, Luqui Qiu⁷, Vanitha Ramakrishnan, PhD²^*, Ruiqi Huang⁸^*, Yang Shi⁹^*, Adam Idoine, PhD²^*, Tommi Salmi, MD¹⁰^*, Aileen Cleary Cohen, MD, PhD² and Mazyar Shadman, MD, MPH¹¹

¹Chronic Lymphocytic Leukemia Center, Division of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA
²BeiGene USA, Inc, San Mateo, CA
³University of Cologne, Dusseldorf, Germany
⁴Columbia University, New York, NY
⁵University of California, Irvine, CA
⁶Alfred Hospital and University of Melbourne, Melbourne, VIC, Australia
⁷Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
⁸BeiGene, Shanghai, China
⁹BeiGene, Beijing, China
¹⁰BeiGene International GmbH, Basel, Switzerland
¹¹Fred Hutchinson Cancer Center, Seattle, WA

1891

Extended Follow-up and Resistance Mutations in CLL Patients Treated with Acalabrutinib

Clare Sun, MD¹, Raghuveer Mali, PhD²^*, Rachel Kositsky, PhD³^*, Xin Tian, PhD⁴^*, Hannah Tomczak³^*, Barrett Nuttall³^*, Rafael White²^*, Simon Rule, MD⁵^*, Veerendra Munugalavadla, PhD² and Adrian Wiestner, MD¹

¹National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
²AstraZeneca, South San Francisco, CA
³AstraZeneca, Waltham, MA
⁴Office of Biostatistics Research, National Heart, Lung, and Blood Institute, Bethesda, MD
⁵AstraZeneca, Mississauga, ON, Canada

1892

An Unsupervised Machine Learning Method Stratifies Chronic Lymphocytic Leukemia Patients into Novel Categories with Different Risk of Early Treatment

Federico Pozzo, PhD¹^*, Francesca Cuturello, PhD²^*, Edith Villegas Garcia²^*, Francesca Rossi³^*, Massimo Degan⁴^*, Paola Nanni⁵^*, Ilaria Cattarossi⁶^*, Eva Zaina⁶^*, Paola Varaschin⁵^*, Alessandra Braida⁶^*, Michele Berton⁵^*, Laura Zannier⁷^*, Filippo Vit, PhD⁸^*, Erika Tissino, PhD⁹^*, Tamara Bittolo¹⁰^*, Roberta Laureana¹¹^*, Giovanni Francesco D'Arena, MD¹²^*, Luca Laurenti, MD¹³^*, Agostino Tafuri, MD¹⁴, Jacopo Olivieri¹⁵^*, Francesco Zaja, MD¹⁶^*, Annalisa Chiarenza, MD¹⁷^*, Francesco Di Raimondo, MD¹⁸, Maria Ilaria Del Principe, MD¹⁹^*, Riccardo Bomben¹⁰^*, Antonella Zucchetto, PhD²⁰^*, Alessio Ansuini²^*, Chris Fegan²¹^*, Chris Pepper²²^*, Andrea Pepper²²^*, Kari G. Rabe, MS²³^*, Sameer A. Parikh, MD²⁴, Neil E. Kay, MD²⁵, Alberto Cazzaniga²^* and Valter Gattei, MD²⁶

¹Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano, Aviano, Italy
²Area Science Park, Trieste, Italy
³Clinical and Experimental Onco-Haematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano (PN), ITA
⁴Clinical and Experimental Onco-Haematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy
⁵Centro Di Riferimento Oncologico Di Aviano (CRO) IRCCS, Aviano, ITA
⁶Centro di Riferimento Oncologico di Aviano, Aviano, Italy
⁷Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Italy, Aviano, Italy
⁸Clinical and Experimental Onco-Haematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy, ITA
⁹Clinical and Experimental Onco-Hematology Unit, Centro Di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy
¹⁰CRO Aviano National Cancer Institute,Clinical and Experimental Onco-Hematology Unit, Aviano, Italy
¹¹Division of Haematology, University of Tor Vergata, Rome, Roma, ITA
¹²IRCCS Centro Di Riferimento Oncologico Della Basilicata, Rionero In Vulture, PZ, ITA
¹³Division of Hematology, Fondazione Universitaria Policlinico A Gemelli di Roma, Rome, Italy
¹⁴Department of Clinical and Molecular Medicine and Hematology, Sant'Andrea - University Hospital - Sapienza, University of Rome, Rome, Italy
¹⁵Clinica Ematologica, Centro Trapianti e Terapie Cellulari "Carlo Melzi", Azienda Sanitaria Universitaria Integrata di Udine, Udine, Italy
¹⁶DSM, University of Trieste, Trieste, Italy
¹⁷Division of Hematology, Policlinico, Department of Surgery and Medical Specialties, University of Catania, Catania, Catania, Italy
¹⁸Division of Hematology, Policlinico, Department of Surgery and Medical Specialties, University of Catania, Catania, ITA
¹⁹Hematology, Department of Biomedicine and Prevention, University Tor Vergata, Roma, Italy
²⁰Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy
²¹Cardiff University School of Medicine, Cardiff, United Kingdom
²²Brighton and Sussex Medical School, Brighton, UK, Brighton, United Kingdom
²³Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN
²⁴Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN
²⁵Division of Hematology, Mayo Clinic, Rochester, MN
²⁶Centro Di Riferimento Oncologico, Aviano, Italy

1893

Single-Cell Long-Read Sequencing Enables the Dissection of BTK Subclonal Dynamics in CLL Treatment

Gage Black¹^*, Xiaomeng Huang, PhD¹^*, Yi Qiao, PhD¹^*, Philip Moos, PhD²^*, Deborah M. Stephens, DO³, Gabor Marth, DSc¹^* and Jennifer A. Woyach, MD⁴

¹Department of Human Genetics, University of Utah, Salt Lake City, UT
²Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT
³Huntsman Cancer Institute, University of Utah, Salt Lake City, UT
⁴The Ohio State University Comprehensive Cancer Center, Columbus, OH

1894

High Dimensional Detection of Non-Malignant B-Cells and Its Clinical Implications in Patients with Chronic Lymphocytic Leukaemia (CLL) Undergoing Frontline Therapy

Yeong Jer Lim^1,2^*, Andrew Duckworth³^*, Kim Clarke⁴^*, Melanie Oates³^*, Matthew Gornall⁵^*, Nagesh Kalakonda^1,3^*, Joseph Slupsky³^* and Andrew Pettitt, MD, PhD^1,3^*

¹The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool, United Kingdom
²Department of Molecular & Clinical Cancer Medicine, University of Liverpool, Warrington, ENG, United Kingdom
³Department of Molecular & Clinical Cancer Medicine, University of Liverpool, Liverpool, United Kingdom
⁴Computational Biology Facility, University of Liverpool, Liverpool, United Kingdom
⁵Liverpool Clinical Trials Centre, University of Liverpool, Liverpool, United Kingdom

1895

NK Cell Dysfunction in CLL Is Mediated through SHP-1 Signaling and Is Associated with Poor Prognosis

Hila Shaim, MD¹, Hind Rafei, MD¹, Mecit Kaplan¹, Rafet Basar, MD¹^*, May Daher, MD¹, Mayra Shanley, PhD¹^*, Pinaki Banerjee, PhD¹^*, Bijender Kumar, PhD¹^*, Ana K. Nunez Cortes, MD¹^*, Sanjida Islam¹^*, Xin Ru Jiang¹^*, Lucila Nassif Kerbauy, MD, PhD¹, Paul Lin, MD, PhD¹, Elif Gokdemir¹^*, Nadima Uprety¹^*, Sunil Acharya, PhD¹^*, Mayela Carolina Mendt, PhD¹^*, Luciana Melo Garcia, MD, MSc¹, Alexander Biederstädt, MD¹^*, Bin Liu, PhD¹^*, Enli Liu, MD¹^*, Sonny Ang¹^*, Jan A. Burger, MD, PhD ², William G. Wierda, MD, PhD³, Alessandra Ferrajoli, MD⁴, Elizabeth J. Shpall, MD¹ and Katy Rezvani, MD⁵

¹Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas M D Anderson Cancer Center, Houston, TX

1896

ZAP-70 Integrates Tonic B Cell Receptor and Chemokine Signaling in IGHV unmutated Chronic Lymphocytic Leukemia

Chen Jingyu, PhD^1,2^*, Vijitha Sathiaseelan³^*, Chandra Chilamakuri⁴^*, Constanze Jakwerth⁵^*, Clive S D'Santos, PhD³^* and Ingo Ringshausen, MD¹

¹University of Cambridge, Cambridge, United Kingdom
²1. Department of Biochemistry and Molecular Biology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, China
³University of Cambridge, Cambridge, GBR
⁴CRUK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom
⁵Technical University Munich, Munich, DEU

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^*signifies non-member of ASH

641.P1.34 641. Chronic Lymphocytic Leukemias: Basic and Translational: Poster I