Huishou Fan^1,2*, Bing Wang^3*, Lugui Qiu⁴, Bin Ma^3* and Gang An^5*

¹State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Blood Diseases Hospital and Institute of Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, AL, China
²Department of Hematology, Affiliated Hospital of Qingdao University, Qingdao, People's Republic of China., Qingdao, China
³Shanghai Kuaixu Biotechnology Co., Ltd, Shanghai, China
⁴State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology& Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
⁵State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences&Peking Union Medical College, Tianjin, China

Aintzane Zabaleta^1*, Laura Blanco^1*, Peter Kim, PhD^2*, Kamlesh Bisht, PhD^2*, Hongfang Wang, PhD^2*, Helgi J. Van de Velde, MD, PhD², Marta Lasa, PhD^3*, Luis-Esteban Tamariz-Amador, MD^3*, Paula Rodriguez Otero, MD, PhD^4*, Jesús San Miguel, MD, PhD^3*, Bruno Paiva^5* and Esperanza Martín-Sánchez^1*

¹CIMA (Pamplona)Cancer Center Clinica Universidad de Navarra (CCUN), Centro de Investigacion Medica Aplicada (CIMA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), CIBER-ONC numbers CB16/12/00369 and CB16/12/00489, Pamplona, Spain
²Sanofi R&D, North America, Cambridge, MA
³Cancer Center Clinica Universidad de Navarra (CCUN), Centro de Investigacion Medica Aplicada (CIMA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), CIBER-ONC numbers CB16/12/00369 and CB16/12/00489, Pamplona, Spain
⁴Cancer Center Clínica Universidad de Navarra (CCUN), CIMA, CIBERONC, IDISNA, Pamplona, Spain
⁵Cancer Center Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada (CIMA), IDISNA, CIBER-ONC number CB16/12/00369 and CB16/12/00489, Pamplona, Spain

Julie O'Neal, PhD^1*, Julie K. Ritchey^2*, Susan Gladney^1*, Gabriel J. Haas^1*, Ramzi Abboud, MD³, Michael P. Rettig, PhD⁴, Cedric Bruges^1*, Linda Eissenberg, PhD^1* and John F. DiPersio, MD, PhD¹

¹Washington University School of Medicine, Saint Louis, MO
²Department of Medicine, Division of Oncology, Washington University School of Medicine, Saint Louis, MO
³Washington University School of Medicine, Clayton, MO
⁴Division of Oncology, Washington University School of Medicine, Saint Louis, MO

Jia Liu^*, Zilu Zhang^*, Wenbin Xu^*, Qing Yu^*, Ming-Yuan Jia^* and Yan Hua, PhD^*

Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

Laure Dutrieux^1*, Elle Loughran^2,3*, Armelle Choquet^4*, Hélène Herault^4*, Antoine Guillemin^1*, Nicolas Robert^5*, Guilhem Requirand^5*, Guillaume Cartron, MD, Ph-D^6,7,8*, Laure Vincent, MD^9*, Charles Herbaux, MD, PhD^10,11,12*, Eric Rivals^2*, Alexandre David^4* and Jerome Moreaux, PhD^{5,12,13,14,15,16}

¹Institut de Génétique Humaine, Montpellier, France
²LIRMM, Montpellier, France
³Trinity College, Dublin, Ireland
⁴Institut de Génétique Fonctionnelle, Montpellier, France
⁵Department of Biological Hematology, Montpellier University Hospital Center, Laboratory for Monitoring Innovative Therapies, Montpellier, France
⁶Dept. Biological Hematology, Montpellier University Hospital Center, Montpellier, FRA
⁷Clinical Hematology Department, Montpellier University Hospital Center, Montpellier, France
⁸IGMM UMR 5535 CNRS UM, University of Montpellier, Montpellier, France
⁹Department of Clinical Hematology, Montpellier University Hospital Center, Montpellier, France
¹⁰Faculty of Medicine, University of Montpellier, Montpellier, France
¹¹Clinical Hematology Department, Montpellier University Hospital, MONTPELLIER, France
¹²Institute of Human Genetics, CNRS UM UMR 9002, University of Montpellier, MONTPELLIER, France
¹³Faculty of Medicine, University of Medicine, Montpellier, France
¹⁴Institut Universitaire de France, Paris, France
¹⁵Laboratory for Monitoring Innovative Therapies, Department of Biological Hematology, Montpellier University Hospital, Montpellier, France
¹⁶Université Montpellier, Montpellier, France

Natalia Buenache Cuenda^1*, Hipolito Nicolas Cuesta Hernández^1*, Alicia Giménez Sánchez^1*, Laura Carneros Blanco^1*, Juan Manuel Rosa-Rosa, PhD^1*, Yanira Ruiz-Heredia, PhD^1,2*, Enrique Revilla, MD^3*, Seungbin Han^4*, Umair Munawar^5*, Inmaculada Rapado, PhD^1*, Rosa Ayala, MD^1,2*, K. Martin Kortüm, MD^6*, Antonio Valeri, PhD^1*, Santiago Barrio, PhD^1,2*, Joaquin Martinez Lopez, PhD, MD^2,7* and Larissa Haertle^6,8*

¹Department of Hematology, Hospital Universitario 12 de Octubre, Spanish National Cancer Research Center (CNIO), Complutense University Madrid, Madrid, Spain
²Altum Sequencing Co., Madrid, Spain
³Anatomical Pathology Service, Hospital 12 de Octubre, Madrid, Spain
⁴Department of Internal Medicine II, University Hospital Würzburg, Wuerzburg, Germany
⁵Department of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany
⁶Department of Internal Medicine II, University Hospital Wuerzburg, Wuerzburg, Germany
⁷Hospital Universitario 12 de Octubre, Madrid, Spain
⁸Hospital Universitario 12 de Octubre, Spanish National Cancer Research Center (CNIO), Complutense University Madrid, Madrid, Spain

Xin Chen^1*, Liwen Wang^1*, Zuqun Deng^1*, Yishu Tang^1*, Qian Cheng^1*, Depei Wu, M.D.² and Xin Li^1*

¹Department of Hematology, The Third Xiangya Hospital of Central South University, Changsha, China
²Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China

Tarek H. Mouhieddine, MD¹, Junia Vieira dos Santos, MD, PhD^2*, Yogita Ghodke-Puranik, PhD^2*, Adolfo Aleman, MPA³, David Melnekoff, MS^2*, Bhaskar Upadhyaya, PhD^1*, Adeeb Rahman, PhD^4*, Shaked Afik, PhD^4*, Hadas Lewinsky, PhD^4*, Santiago Thibaud, MD^1*, Adriana C Rossi, MD, MSc¹, Shambavi Richard, MD¹, Cesar Rodriguez, MD^1*, Joshua Richter, MD³, Hearn Jay Cho, MD⁵, Larysa Sanchez, MD^3*, Sundar Jagannath, MD⁶, Ajai Chari, MD^7,8*, Alessandro Lagana, PhD¹ and Samir Parekh, MD¹

¹Department of Medicine, Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York
²Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
³Department of Medicine, Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
⁴ImmunAI, New York, NY
⁵Department of Medicine, Hematology and Medical Oncology, Tisch Cancer Institute, Tisch Cancer Institute, New York, NY
⁶Mount Sinai Medical Center, New York, NY
⁷Icahn School of Medicine at Mount Sinai, New York, NY
⁸at the time that the work was performed, Mount Sinai School of Medicine, New York, NY

Nahia Gomez-Echarte^1,2*, Arantxa Carrasco-León^1,3,4*, Alba Maiques-Diaz, PhD^5*, Estibaliz Miranda^1,4,6*, Leire Garate^3,7*, Patxi San-Martin^1,8,9*, Stella Charalampopoulou^10*, Luis Vitores Valcárcel, MSc^11*, Inaki Martin-Subero^12*, Edurne San josé-Eneriz^3,13*, Xabier Agirre, PhD^8* and Felipe Prosper, MD, PhD^14,15,16,17

¹CIMA Universidad de Navarra, Pamplona, Navarra, Spain
²Cancer Centre Clínica Universidad de Navarra (CCUN), Pamplona, Navarre, Spain
³Cancer Centre Clínica Universidad de Navarra (CCUN), Pamplona, Spain
⁴Cancer Networking Biomedical Research Centre (CIBERONC), Madrid, Madrid, Spain
⁵Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
⁶Cancer Centre Clínica Universidad de Navarra (CCUN), Pamplona, Navarra, Spain
⁷Clínica Universidad De Navarra, Pamplona, Navarra, Spain
⁸Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain
⁹Hemato-Oncology Program. Cima Universidad de Navarra. IdiSNA., Pamplona, Spain
¹⁰IDIBAPS, Barcelona, ESP
¹¹Tecnun School of Engineering, University of Navarre, San Sebastián, Spain
¹²IDIBAPS, Barcelona, Spain
¹³CIMA Universidad de Navarra, Pamplona, Spain
¹⁴Hematology and Cell Therapy Department. Clinica Universidad de Navarra, IdiSNA., Pamplona, Spain
¹⁵Cancer Center Universidad de Navarra (CCUN)., Pamplona, Spain
¹⁶Cancer Center Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada (CIMA), IDISNA, CIBER-ONC number CB16/12/00369 and CB16/12/00489, Pamplona, Spain
¹⁷Centro de Investigacion Biomedica en Red de Cancer (CIBERONC), Madrid, Spain

Jiadai Xu^1* and Peng Liu, MD²

¹Department of Hematology, Zhongshan Hospital, Fudan University, Shanghai, China
²Hematology, Zhongshan Hospital Affiliated to Fudan University, Shanghai, China

Aya Ismael^1*, Allen Robinette^2*, Kameron Dona^1,3*, Ruchi Kudalkar^1*, Vincent Manning^1*, Joshua Galloway^1*, Emanuele Cocucci, MD, PhD^4* and Francesca Cottini, MD¹

¹The Ohio State University, Columbus, OH
²Division of Hematology, The Ohio State University Wexner Medical Center, Columbus, OH
³Penn State University, State College, PA
⁴College of Pharmacy, The Ohio State University, Columbus, OH

Ciara Louise L. Freeman, MD, PhD, MSc¹, Julieta Abraham Miranda, PhD^2*, Meghan Menges^3*, Jerald Noble, PhD^3,4*, Hien Liu, MD³, Salvatore Corallo^5*, Albert J Ribickas^6*, Constanza Savid-Frontera, PhD^3*, Gabriel De Avila, BS^7*, Omar Castaneda, MD¹, Jose L. Ochoa-Bayona, MD^5*, Rachid Baz, MD⁸, Doris K. Hansen, MD⁵, Melissa Alsina, MD^1*, Kenneth H. Shain, MD, PhD⁹, Taiga Nishihori, MD⁵, Reginald Atkins, PhD^10* and Frederick L. Locke, MD⁵

¹Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
²H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
³Moffitt Cancer Center, Tampa, FL
⁴Department of Clinical Science, H Lee Moffitt Cancer Center, Tampa, FL
⁵Department of Blood and Marrow Transplantation and Cellular Immunotherapy, Moffitt Cancer Center, Tampa, FL
⁶H. Lee Moffitt Cancer Center, Tampa, FL
⁷H. Lee Moffitt Cancer Center and Research Institute, Tampa
⁸Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
⁹H. Lee Moffitt Cancer Center & Research Institute, Saint Petersburg, FL
¹⁰Department of Clinical Science, Moffitt Cancer Center, Tampa, FL

David E. Mery, PhD¹, Visanu Wanchai, PhD^1*, Cody Ashby, PhD^2*, Hongwei Xu, DDS^3*, Eric Siegel^4*, Clyde Bailey, BS^5*, Guido Tricot, MD^1*, John D Shaughnessy, Jr, PhD^1* and Fenghuang Zhan, MD, PhD²

¹Myeloma Center, Winthrop P. Rockefeller Cancer Institute, University of Arkansas For Medical Sciences, Little Rock, AR
²Myeloma Center, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR
³Myeloma Center, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical, Little Rock, AR
⁴Department of Biostatistics, University of Arkansas For Medical Sciences, Little Rock, AR
⁵Myeloma Center, Winthrop P. Rockefeller Institute, University of Arkansas for Medical Sciences, Little Rock, AR

Deeksha Vishwamitra, PhD¹, Sheri Skerget^1*, Diana Cortes, PhD^1*, Onsay Lau^1*, Cuc Davis^1*, Thomas Renaud, MD², Jaszianne Tolbert, MD¹, Brandi W Hilder, PhD¹, Tara J Masterson, MS^1*, Michela Campagna, PhD^3*, Christoph Heuck^1*, Ajai Chari, MD^4*, Niels W.C.J van de Donk, MD, PhD^5* and Raluca Verona, PhD¹

¹Janssen Research & Development, Spring House, PA
²Janssen Research & Development, Raritan, NJ
³Janssen Research & Development, Madrid, Spain
⁴at the time that the work was performed, Mount Sinai School of Medicine, New York, NY
⁵Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, Netherlands

Debasmita Dutta, PhD, Jiye Liu, PhD^*, Kenneth Wen, BS^*, Keiji Kurata^*, Mariateresa Fulciniti, PhD, Annamaria Gulla, MD, Teru Hideshima^* and Kenneth C. Anderson, MD

Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA

Milena Colovic, PhD^1,2*, Matthew Nodwell, PhD^3*, Leo Escano, BS^4*, Nadine Colpo^5*, Ingrid Bloise, MD^5*, Gokce Engudar, PhD^6*, Helen Merkens^7*, Francois Benard, MD^8*, Paul Schaffer, PhD^9*, Florian Kuchenbauer, MD, PhD, FRCPC¹⁰ and Robert Britton, PhD^11*

¹Life Sciences Division, TRIUMF, Vancouver, BC, Canada
²Molecular Oncology, BC Cancer, Vancouver, BC, Canada
³Simon Fraser University, Burnaby, BC, Canada
⁴Terry Fox Laboratory, British Columbia Cancer Research Institute, Vancouver, Canada
⁵BC Cancer, Vancouver, Canada
⁶Life Sciences Division, TRIUMF, Vancouver, Canada
⁷Molecular Oncology, BC Cancer, Vancouver, Canada
⁸BC Cancer, Vancouver, BC, CAN
⁹TRIUMF, Vancouver, BC, Canada
¹⁰BC Cancer Research Centre, Vancouver, BC, Canada
¹¹Simon Fraser University, Burnaby, Canada

Stefan Forster, MD^1*, Chantal Bachmann^2*, Maxime Boy, PhD^1*, Ramin Radpour, PhD^1*, Christian M Schuerch, MD, PhD^3*, Frido Brühl, MD^4*, Carsten Riether, PhD¹ and Adrian Ochsenbein, MD⁵

¹University and University Hospital of Bern, Bern, Switzerland
²Department for Biomedical Research, University of Bern, Bern, Switzerland
³Department of Pathology and Neuropathology, University Hospital Tübingen, Tübingen, Germany
⁴From Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH
⁵University Hospital of Bern, Bern, Switzerland

Andrey Pisarev^1*, Munevver Cinar, MD^2*, Lourdes Martinez-Medina^3*, Deon B. Dixie^4*, Li Feng^5*, Pavan Puvvula, PhD^6*, Stephen Chang^3* and Leon Bernal-Mizrachi, MD⁴

¹Kodikaz Therapeutic Solutions, LLC, new york, NY
²Emory University Winship Cancer Institute, Atlanta, GA
³Kodikaz Therapeutic Solutions, LLC, New York, NY
⁴Winship Cancer Institute of Emory University, Atlanta, GA
⁵Kodikaz therapeutic Solutions, New York, NY
⁶Kodikaz Therapuetic Solutions, New York, NY

Florian Eisele^1*, Nazia Afrin^2*, Emilia Stanojkovska^2*, Mara John^2*, Moutaz Helal, MSc^2*, Lars Grundheber^2*, Philipp Weis, MD^3*, Christine Riedhammer^4*, Sofie-Katrin Kadel, MD^5*, Max Steinhardt^6*, Johannes Duell, MD^7*, Johannes M Waldschmidt, MD⁸, Hermann Einsele, MD, PhD^3*, Angela Riedel, PhD^2*, K. Martin Kortüm, MD^3* and Leo Rasche, MD^2,3*

¹Department of Internal Medicine II, University Hospital Würzburg, WüRzburg, Germany
²Mildred Scheel Early Career Center for Cancer Research, University Hospital Wurzburg, Wurzburg, Germany
³Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany
⁴Department of Internal Medicine II, University of Regensburg, Regensburg, Germany
⁵Department of Internal Medicine II, University Hospital Wurzburg, Wurzburg, Germany
⁶Department of Internal Medicine II, University Hospital Wuerzburg, Wuerzburg, Germany
⁷Department of Internal Medicine II, Hematology and Oncology, University Hospital Wuerzburg, Wuerzburg, Germany
⁸Department of Internal Medicine II, University of Wuerzburg Medical Center, Wuerzburg, Germany

Rajib Shome, PhD¹, Srikanth Talluri, PhD^2,3*, Tsuyoshi Fukushima, MD, PhD^4*, Mehmet K. Samur, PhD³, Rie Nakamoto-Matsubara, MD, PhD^5*, Cristina Panaroni, PhD^5*, Keertik Fulzele, PhD^5*, Kiyosumi Ochi, MD, PhD^5*, Ryan Seongmin Han^5*, Farah Rexha^5*, David Scadden, MD⁴, Nikhil C Munshi, MD^2,6* and Noopur S. Raje, MD⁷

¹Center for Multiple Myeloma, Massachusetts General Hospital, Harvard Medical School, Boston, MA
²VA Boston Heathcare System, Boston, MA
³Dana Farber Cancer Institute, Harvard Medical School, Boston, MA
⁴Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA
⁵Center for Multiple Myeloma, Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA
⁶Dana-Farber Cancer Institute, Boston, MA
⁷Center for Multiple Myeloma, Massachusetts General Hospital, Boston, MA

Wassilis S.C Bruins, MD, MSc^1,2*, Carolien Duetz, MD^1,2*, Kaz Groen, MD^1,2*, Charlotte L.B.M. Korst^1,2*, A. De Jonge^1,2*, Rosa Rentenaar^1,2*, Meliha Cosovic^1,2*, Merve Eken^1,2*, Inoka Twickler^1,2*, Paola Homan-Weert^1,2*, Christie P.M. Verkleij, MD^1,2*, Kristine A. Frerichs, MD^1,2*, Niels W.C.J van de Donk, MD, PhD^1,2*, Sonja Zweegman, MD, PhD^1,2 and Tuna Mutis, MD PhD^1,2*

¹Cancer Biology and Immunology, Cancer Center Amsterdam, Amsterdam, Netherlands
²Department of Hematology, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, Netherlands

Noemie Leblay, PhD^1*, Sungwoo Ahn, PhD^1*, Sheri Skerget, PhD², Rémi Tilmont, MD^1*, Holly Lee, MD^1*, Mansour Poorebrahim, PhD^1*, Daniel Penaherrera, BSc^2*, Elie Barakat^1*, David Jung^1*, Nizar J Bahlis, MD³, Jonathan Keats, PhD² and Paola Neri, MD, PhD³

¹Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, Canada
²TGen, Phoenix, AZ
³Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, AB, Canada

Selma Bekri, PhD^1*, Simone Katz^2*, Geoffrey Kelly^3*, Travis Dawson, PHD^4*, Darwin D'Souza^5*, Michael Mason^6*, Alexandre Alloy^6*, Shameek Biswas^6*, Seunghee Kim-Schulze, PhD^4*, Sacha Gnjatic^7*, Samir Parekh, MD⁸, Sundar Jagannath, MD⁹, Alessandro Lagana, PhD⁸ and Hearn Jay Cho, MD¹⁰

¹Tisch Cancer Institute, Icahn School of Medicine At Mount Sinai, New York, NY
²Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
³Department of Immunology & Immunotherapy, Icahn School of Medicine At Mount Sinai, New York, NY
⁴Department of Immunology & Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY
⁵Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY
⁶Bristol Myers-Squibb, Seattle, WA
⁷Icahn School of Medicine at Mount Sinai, New York, NY
⁸Department of Medicine, Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York
⁹Mount Sinai Medical Center, New York, NY
¹⁰Department of Medicine, Hematology and Medical Oncology, Tisch Cancer Institute, Tisch Cancer Institute, New York, NY

Filip Garbicz^1,2*, Irena Misiewicz-Krzeminska^3*, Ruben D. Carrasco, MD, PhD^4* and Przemysław Juszczyński, MD, PhD^3*

¹Institute of Hematology and Transfusion Medicine, Warszawa, Mazowieckie, Poland
²Dana-Farber Cancer Institute, Department of Pathology, Boston, MA
³Institute of Hematology and Transfusion Medicine, Warsaw, Poland
⁴Dana-Farber Cancer Institute, Harvard Medical School, Department of Oncologic Pathology, Boston, MA

Gabriel Alvares Borges, PhD, MSc¹, Marta Diaz-delCastillo, PhD², Angelo Jose Guilatco, BS^1,3*, Fatima Ali Mustapha^4*, Bilal El Masari^5*, Michael Tveden Gundesen^5*, Maja Hinge^6*, Charlotte Guldborg Nyvold, MSc, PhD^7*, Thomas Lund^8*, Tamar Tchkonia, PhD^9*, James L. Kirkland, MD, PhD^9*, Taxiarchis Kourelis, MD¹, Matthew T. Drake, MD, PhD^1,10, Thomas Levin Andersen, PhD^4* and Megan Weivoda, PhD¹

¹Division of Hematology, Mayo Clinic, Rochester, MN
²Aarhus University, Aarhus, DNK
³Doctoral Program in Cancer Biology, University of Michigan, Ann Arbor, MI
⁴Aarhus University, Aarhus, Denmark
⁵University of Southern Denmark, Odense, Denmark
⁶Vejle Hospital, Vejle, DNK
⁷University of Southern Denmark, Odense C, DNK
⁸University of Southern Denmark, Odense, DNK
⁹Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN
¹⁰Division of Endocrinology, Mayo Clinic, Rochester, MN

Holly Lee, MD^1*, Sungwoo Ahn, PhD^1*, Ranjan Maity, PhD^1*, Noemie Leblay, PhD^2*, Michael Durante, PhD^3*, Bachisio Ziccheddu^3*, Alexis Brake^3*, Remi Tilmont, MD^1*, Elie Barakat^1*, Mansour Poorebrahim, PhD^2*, Ola Landgren, MD³, Benjamin Diamond, MD³, Francesco Maura, MD⁴, Paola Neri, MD, PhD² and Nizar J Bahlis, MD²

¹Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, Canada
²Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, AB, Canada
³Sylvester Comprehensive Cancer Center, Myeloma Division, University of Miami, Miami, FL
⁴Sylvester Comprehensive Cancer Center, Myeloma Division, University of Miami, PALMETTO BAY, FL

Kris Richardson, PhD^1*, Nickolas Tsakmaklis, BA^1*, Maria Luisa Guerrera, MD¹, Amanda Kofides^1*, Xia Liu, MD^1*, Shirong Liu, MD, PhD^1*, Catherine A. Flynn, NP^1*, Kirsten Meid, MPH^1*, Christopher J Patterson^1*, Mariateresa Fulciniti, PhD², Mehmet K. Samur, PhD³, Kenneth C. Anderson, MD², Nikhil C Munshi, MD^2*, Shayna R Sarosiek¹, Jorge J. Castillo, MD¹, Zachary R Hunter, PhD¹ and Steven P. Treon, MD, PhD, FRCP¹

¹Dana-Farber Cancer Institute, Bing Center for Waldenström Macroglobulinemia, Boston, MA
²Dana-Farber Cancer Institute, Harvard Medical School, The Jerome Lipper Multiple Myeloma Center, Boston, MA
³Dana-Farber Cancer Institute, Harvard Medical School, Jerome Lipper Multiple Myeloma Center, LeBow Institute for Myeloma Therapeutics, Boston, MA

Hayley Parkinson, BSc^1,2*, James Breen, PhD^3*, Nhi Hin, PhD^3*, Vasilios Panagopoulos, PhD^1,2*, Andrew Zannettino, PhD^1,2*, Kate Vandyke, PhD^1,2* and Duncan Hewett, PhD^1,2*

¹Myeloma Research Laboratory, Faculty of Health and Medical Sciences, School of Biomedicine, The University of Adelaide, Adelaide, SA, Australia
²Precision Cancer Medicine Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia
³South Australian Genomics Center (SAGC), South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia

Iryna Dekhtiarenko, PhD^1*, Iva Lelios, PhD^2*, Wolfgang Jacob, PhD^3*, Meike Schneider, MD^2*, Martin Weisser, MD PhD^3*, Carmelo Carlo-Stella, Prof MD⁴, Salomon Manier, MD, PhD⁵, Simon J. Harrison, MBBS, MRCP, FRCPath, FRACP, PhD⁶, Rakesh Popat^7*, Anna Caroline Hasselbalch Riley, MD^8* and Ann-Marie E. Bröske, PhD^3*

¹Roche Innovation Center Zurich, Zurich, Switzerland
²Roche Innovation Center Basel, Basel, Switzerland
³Roche Innovation Center Munich, Penzberg, Germany
⁴Humanitas University and IRCCS Humanitas Research Hospital, Milan, Italy
⁵CHU de Lille, Lille, France
⁶Peter MacCallum Cancer Center, Sir Peter MacCallum Department of Oncology, University of Melbourne and The Royal Melbourne Hospital, Melbourne, VIC, Australia
⁷Department of Haematology, University College London Hospitals NHS Foundation Trust, London, United Kingdom
⁸Department of Hematology, Rigshospitalet, Copenhagen, Denmark

Alizée Steer, PhD^1,2*, Elina Alaterre, PhD^1*, Djamila Chamlal^1*, Emmanuel Varlet^3*, Amélie Machura^1*, Alboukadel Kassambara, PhD^4*, Guilhem Requirand^5*, Nicolas Robert^5*, Laure Vincent, MD^6*, Charles Herbaux, MD, PhD^7*, Hugues De Boussac, PhD^1*, Angélique Bruyer^1* and Jerome Moreaux, PhD^3,8,9

¹Diag2tec, Montpellier, France
²Institute of Human Genetics, CNRS, The French National Centre for Scientific Research, Montpellier Cedex 5, AL, France
³Institute of Human Genetics, CNRS, Montpellier, France
⁴Diag2tec, Montpellier, FRA
⁵Department of Biological Hematology, Montpellier University Hospital Center, Laboratory for Monitoring Innovative Therapies, Montpellier, France
⁶Department of Clinical Hematology, Montpellier University Hospital Center, Montpellier, France
⁷Clinical Hematology Department, Montpellier University Hospital, MONTPELLIER, France
⁸Faculty of Medicine, University of Medicine, Montpellier, France
⁹Laboratory for Monitoring Innovative Therapies, Department of Biological Hematology, Montpellier University Hospital Center, Montpellier, France

Vivian Zhou, MD, PhD^1*, Luke Moat, Bachelor^2*, Manya Yu, BM^1*, Deepak Parashar, PhD^1*, Abdul Shour, PhD^3*, Liang Zhang, PhD^4*, Terrie Kitchner^3*, Sanjay Shukla, PhD^5*, Song Guo^6*, Gene Ananiev, PhD^6*, Benita S. Katzenellenbogen, PhD^7*, John Katzenellenbogen, PhD^8*, Adedayo Onitilo, MD, PhD^9*, Siegfried Janz, MD, DSc¹ and Zhi Wen, MD, PhD²

¹Medical College of Wisconsin, Milwaukee, WI
²Center for Precision Medicine Research, Marshfield Clinic Research Institute, Marshfield, WI
³Marshfield Clinic Research Institute, Marshfield
⁴Medical College of Wisconsin, Milwaukee
⁵Marshfield Clinic Research Institute, Marshfield, WI
⁶University of Wisconsin-Madison, Madison
⁷Departments of Physiology and Chemistry, Cancer Center, University of Illinois At Urbana-Champaign, Urbana, IL
⁸Department of Physiology and Chemistry, Cancer Center, University of Illinois at Urbana-Champaign, Urbana-Champaign, IL
⁹Cancer Care & Research Center, Marshfield Clinic Research Foundation, Marshfield, WI

Giulia Giorgetti^1,2*, Pamela Becherini^2*, Elena Maroto-Martin^1,3*, Daniela Fenoglio^4,5*, Debora Soncini^2*, Claudia Martinuzzi^4*, Santina Bruzzone^6*, Andrea Benzi^6*, Aimable Nahimana^7*, Chiara Rosa Maria Uras^8*, Anaïs Schavgoulidze^1,9*, Jessica Ng Fong^1*, Roberto M. Lemoli, MD^10,11*, Nikhil C Munshi, MD^1,3,12*, Mariateresa Fulciniti, PhD^1,3 and Michele Cea^4,13*

¹Department of Medical Oncology, Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Boston, MA
²Clinic of Hematology, Department of Internal Medicine and Medical Specialties (DiMI), University of Genoa, Genova, Italy
³Harvard Medical School, Boston, MA
⁴IRCCS Ospedale Policlinico San Martino, Genova, Italy
⁵Centre of Excellence for Biomedical Research and Department of Internal Medicine, University of Genoa, Genova, Italy
⁶Department of Experimental Medicine (DIMES), University of Genoa, Genova, Italy
⁷Central Laboratory of Hematology, Department of Medical Laboratory and Pathology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
⁸Department of Experimental Medicine, Centre of Excellence for Biomedical Research, University of Genoa, Genova, Italy
⁹Toulouse Cancer Research Center-Oncopole, Toulouse University, INSERM UMR1037, Toulouse, France
¹⁰Clinic of Hematology, Department of Internal Medicine (DiMI), University of Genoa, Genoa, Italy
¹¹IRCCS - San Martino Hospital, Genoa, Italy
¹²VA Boston Heathcare System, Boston, MA
¹³Clinic of Hematology, Department of Internal Medicine (DiMI), University of Genoa, Genova, Italy

Maria Luisa Guerrera, MD¹, Amanda Kofides^1*, Xia Liu, MD^1*, Nickolas Tsakmaklis, BA^1*, Kris Richardson, PhD^1*, Shirong Liu, MD, PhD^1*, Christopher J Patterson^1*, Catherine A. Flynn, NP^1*, Kirsten Meid, MPH^1*, Nikhil C Munshi, MD^2*, Kenneth C. Anderson, MD², Shayna R Sarosiek¹, Jorge J. Castillo, MD¹, Steven P. Treon, MD, PhD, FRCP¹ and Zachary R Hunter, PhD¹

¹Dana-Farber Cancer Institute, Bing Center for Waldenström Macroglobulinemia, Boston, MA
²Dana-Farber Cancer Institute, Harvard Medical School, The Jerome Lipper Multiple Myeloma Center, Boston, MA