Sindhusha Veeraballi, MD^1*, Ran Zhao^2*, Megha Sai Konka^3*, Hetty E. Carraway, MD, MBA⁴, Moaath K. Mustafa Ali, MD, MPH⁵, Aaron T. Gerds, MD, MS⁶, Arooj Ahmed, MD^1*, Anjali S. Advani, MD⁷, John C Molina, MD, MEd⁸, Sophia Balderman, MD^8*, Abhay Singh, MD, MPH⁹ and Sudipto Mukherjee, MD, PhD, MPH¹⁰

¹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
²Cleveland Clinic, Cleveland, OH
³Department of Medicine, Kent State College of Podiatric Medicine, Independence, OH
⁴Department of Hematology and Medical Oncology, Taussig Cancer institute, Leukemia Program, Cleveland Clinic, Cleveland, OH
⁵Leukemia Division, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH
⁶Leukemia Program, Department of Hematology and Medical Oncology, Cleveland Clinic, Cleveland, OH
⁷Leukemia Program, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
⁸Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
⁹Taussig cancer center, Cleveland Clinic, Cleveland Clinic, Cleveland, OH
¹⁰Department of Hematology and Medical Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH

Liya Ma^1*, Wenli Yang^2*, Xinping Zhou^3*, Li Ye^2*, Gaixiang Xu^4*, Chao Hu^2*, Yingwan Luo^2*, Chunmei Yang^1*, Zheng Ge, MD, PhD⁵ and Hongyan Tong, PhD^6*

¹Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, PR China;, Hangzhou, China
²Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
³Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
⁴Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, Hangzhou, China
⁵Zhongda Hospital Southeast University, Nanjing, China
⁶The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China

Kelly S. Chien, MD¹, Samuel Urrutia, MD², Ziyi Li, PhD^3*, Rashmi Kanagal-Shamanna, MD⁴, Ahmed Abdelhakeem, MD^1*, Tareq Abuasab, MD^1*, Emmanuel Almanza, MD^1*, Georgina Gener-Ricos^1*, Alex Bataller, MD, PhD^1*, Alexandre Bazinet, MD^1*, Guillermo Montalban-Bravo, MD¹, Nicholas J. Short, MD¹, Elias Jabbour¹, Tapan M. Kadia, MD¹, Farhad Ravandi, MD, MBBS¹, Gautam Borthakur, MD¹, Danielle E. Hammond, MD¹, Mahesh Swaminathan, MD¹, Koji Sasaki, MD¹, Xiao Qin Dong^1*, Sherry Pierce, BSN, BA^1*, Hagop Kantarjian, MD¹ and Guillermo Garcia-Manero, MD¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX

Ines Zugasti^1,2*, Sandra Castaño-Díez, MD^1,2,3*, Daniel Esteban^1,4*, Alejandro Avendaño Pita^2,5*, Helena Pomares, MD, PhD^2,6*, Ana Pérez González, MD^2,7*, Sara Garcia-Avila, MD^2,8*, Irene Padilla-Conejo, MD^2,9*, Cristina de la Fuente, MD^2,10*, Alexandra Martínez-Roca, MD^1,4*, Francesca Guijarro, MD^1,4*, José Ramón Álamo Moreno, MD^1,3*, Carlos Jimenez-Vicente, MD^1,3*, Albert Cortés-Bullich, MD^1,4*, Victor Torrecillas, Medical Student^11*, Ares Guardia, MD^1*, Daniel Munárriz, MD^1*, Esther Carcelero^1*, Maria Suarez-Lledo, MD, PhD^1,4*, Maria Queralt Salas^1,4*, Felix Lopez, MD^2,8*, Fernando Ramos, MD, MPH, PhD^2,9*, Blanca Xicoy, MD^2,10*, David Valcarcel, MD, PhD^2,7, Montserrat Arnan Sangerman, MD, PhD^2,6*, Maria Diez-Campelo, MD, PhD^2,12*, Carmen Martinez, MD, PhD^1,4*, Montserrat Rovira, MD, PhD^1,4*, Francesc Fernández-Avilés, MD^1,4*, Jordi Esteve, MD, PhD^3,13 and Marina Díaz-Beyá, MD, PhD^2,3,13*

¹Hospital Clínic de Barcelona, Barcelona, Spain
²Grupo Español de Síndromes Mielodisplásicos (GESMD), Madrid, Spain
³Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), Barcelona, Spain
⁴Fundació de Recerca Clínic Barcelona-Institut d’Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), Barcelona, Spain
⁵Hospital Universitario de Salamanca, Salamanca, Spain
⁶Institut Català d’Oncologia , Hospital Duran i Reynals, Barcelona, Spain
⁷Vall d´Hebron Institute of Oncology (VHIO), Hospital Universitari Vall d’Hebrón, Barcelona, Spain
⁸Hospital del Mar, Barcelona, Spain
⁹Hospital Universitario de León, Leon, Spain
¹⁰Institut Català d'Oncologia, Hospital Germans Trias i Pujol, Barcelona, Spain
¹¹Universitat de Barcelona, Barcelona, Spain
¹²University Hospital of Salamanca, Salamanca, Spain
¹³Hematology Department, Hospital Clínic Barcelona, Barcelona, Spain

Hongyan Tong^1*, Sujun Gao^2*, Wei Yang^3*, Junmin Li^4*, Qingsong Yin, PhD^5*, Xingli Zhao^6*, Xiaojing Yan^7*, Sanfang Tu^8*, Fei Li^9*, Haiping Yang^10*, Ronghua Hu^11*, Shaoyuan Wang^12*, Zheng Dong^13*, Yixuan Yang^14*, Zhenjiu Wang^14*, Qiying Lu^14*, Wenzhi Tian^14*, Zhijian Xiao^15* and Jianxiang Wang, MD¹⁶

¹The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
²The First Hospital of Jilin University, Changchun, China
³Department of Hematology, Shengjing Hospital of China Medical University, Shenyang, China
⁴Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
⁵Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China
⁶Tianjin People's Hospital, Tianjin, China
⁷The First Hospital of China Medical University, Shenyang, China
⁸Department of Hematology, Zhujiang Hospital of Southern Medical University, Guangzhou, China
⁹The First Affiliated Hospital of Nanchang University, Nanchang, China
¹⁰The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China
¹¹Xuanwu Hospital of Capital Medical University, Beijing, China
¹²Fujian Medical University Union Hospital, Fuzhou, China
¹³ImmuneOnco Biopharmaceuticals (Shanghai) Inc., Beijing, China
¹⁴ImmuneOnco Biopharmaceuticals (Shanghai) Inc., Shanghai, China
¹⁵Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
¹⁶State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Tianjin, China

Amy E. DeZern, MD, MHS¹, Johannes Goll, MSc^2*, Travis L Jensen, BS^2*, Sridhar N Srivatsan^3*, Nancy K Gillis, PhD^4*, Gregory A Abel, MD, MPH⁵, Eric Padron, MD⁶, H. Joachim Deeg, MD⁷, Tareq Al Baghdadi, MD^8*, Jane Lijun Liu^9*, Rami S. Komrokji, MD⁶, Steven D. Gore, MD¹⁰, Wael Saber, MD, MS^11*, Rafael Bejar, MD, PhD¹², Matthew J. Walter, MD¹³, Seth Sherman^14*, Nancy DiFronzo, PhD^15* and Mikkael A. Sekeres, MD¹⁶

¹Johns Hopkins University, Baltimore, MD
²The Emmes Company, Rockville, MD
³Washington University in St. Louis, St. Louis, MO
⁴Department of Malignant Hematology, H. Lee Moffitt Cancer Center, Tampa, FL
⁵DFCI, Boston, MA
⁶Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL
⁷Fred Hutchinson Cancer Research Center, Seattle, WA
⁸IHA Hematology Oncology Consultants, Ypsilanti, MI
⁹Illinois CancerCare, Peoria, IL
¹⁰Division of Cancer Prevention, National Cancer Institute, Rockville, MD
¹¹Medical College of Wisconsin, Milwaukee, WI
¹²University of California, San Diego, La Jolla, CA
¹³Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO
¹⁴The Emmes Company, LLC, Rockville, MD
¹⁵Division of Blood Diseases & Resources, The National Heart, Lung, and Blood Institute, Bethesda, MD
¹⁶Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL

Sankalp Arora, MBBS¹, Jayastu Senapati, MD, MBBS, DM², Naveen Pemmaraju, MD², Prithviraj Bose, MD³, Lucia Masarova, MD², Guillermo Montalban-Bravo, MD², Abhishek Maiti, MD⁴, Tapan M. Kadia, MD², Elias Jabbour⁵, Guillermo Garcia-Manero, MD⁶, Hagop M. Kantarjian, MD² and Naval Daver, MD²

¹Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Leukemia, MD Anderson Cancer Center, Houston, TX
⁵University of Texas M.D. Anderson Cancer Ctr., Houston, TX
⁶University of Texas MD Anderson Cancer Center, Houston, TX

Maria Sirenko, PhD^1,2, Elsa Bernard, PhD^2*, Maria Creignou, MD^3*, Dylan Domenico^2*, Andrea Farina, PhD^4*, Juan E Arango Ossa^2*, Olivier Kosmider, MD, PhD^5*, Robert Hasserjian⁶, Martin Jädersten, MD, PhD^7*, Ulrich Germing^8*, Guillermo Sanz, MD, PhD^9*, Arjan A. van de Loosdrecht, MD, PhD¹⁰, Carmelo Gurnari, MD¹¹, Matilde Yung Follo, PhD^12*, Felicitas Thol¹³, Lurdes Zamora, PhD^14*, Andrea Pellagatti^15*, Harold K Elias, MD¹⁶, Detlef Haase, MD, PhD^17*, Christina Ganster, PhD¹⁸, Lionel Ades, MD, PhD¹⁹, Magnus Tobiasson, MD^20*, Laura Palomo, PhD^21*, Matteo Giovanni Della Porta, MD^22*, Kety Huberman^4*, Pierre Fenaux, MD, PhD²³, Monika Belickova, PhD^24*, Michael R. Savona, MD²⁵, Virginia M. Klimek, MD^26*, Fabio P. S. Santos, MD²⁷, Jacqueline Boultwood, PhD^28*, Ioannis Kotsianidis, MD, PhD²⁹, Valeria Santini, MD³⁰, Francesc Sole, PhD³¹, Uwe Platzbecker, MD³², Michael Heuser, MD¹³, Peter Valent, MD³³, Carlo Finelli, MD^34*, Maria Teresa Voso, MD³⁵, Lee-Yung Shih, MD³⁶, Seishi Ogawa³⁷, Michaela Fontenay, MD, PhD^38*, Joop H. Jansen, PhD^39*, Jose Cervera, MD, PhD^40*, Benjamin L. Ebert, MD, PhD^41,42, Rafael Bejar, MD, PhD⁴³, Peter L. Greenberg, MD⁴⁴, Norbert Gattermann, MD⁴⁵, Luca Malcovati, MD⁴⁶, Mario Cazzola, MD⁴⁷, David B Beck, MD, PhD^48*, Eva Hellstrom Lindberg, MD, PhD^20* and Elli Papaemmanuil, PhD²

¹Gerstner Sloan Kettering Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY
²Computational Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY
³Phase 1 Unit, Center for Clinical Cancer Studies, Karolinska University Hospital, Stockholm, Sweden
⁴Integrated Genomics Operation, Memorial Sloan Kettering Cancer Center, New York, NY
⁵Cochin Hospital, Paris, FRA
⁶Harvard Medical School, Boston, MA
⁷Karolinska University Hospital, Huddinge, SWE
⁸Department of Hematology, Oncology and Clinical Immunology, Universitatsklinik Dusseldorf, Dusseldorf, Germany
⁹Health Research Institute La Fe, Valencia, Spain, Valencia, Spain
¹⁰Department of Hematology, Amsterdam UMC, location VUmc, CCA, Amsterdam, Netherlands
¹¹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
¹²Department of Biomedical and Neuromotor Sciences, Cell Signalling Laboratory, University of Bologna, Bologna, Italy
¹³Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
¹⁴Hematology Department, Institut Català d’Oncologia - Hospital Universitari Germans Trias i Pujol, Institut de Recerca Contra la Leucèmia Josep Carreras, Universitat Autònoma de Barcelona, Badalona, Spain
¹⁵University of Oxford, Oxford, United Kingdom
¹⁶National Institutes of Health, Bethesda, MD
¹⁷Clinics of Hematology and Medical Oncology, University Medical Center Göttingen, Georg-August- University, Goettingen, Germany
¹⁸INDIGHO Laboratories, University Medical Center, Goettingen, DEU
¹⁹Saint Louis Hospital, APHP, Paris, France
²⁰Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Stockholm, SWE
²¹Experimental Hematology Unit,Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain
²²Humanitas Clinical and Research Center, IRCCS, Rozzano, Italy
²³Department of Hematology, Université de Paris, Saint-Louis Hospital, Paris, France
²⁴First Faculty of Medicine, Institute of Clinical and Experimental Hematology, Charles University, Prague, Czech Republic
²⁵Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN
²⁶Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY
²⁷Hospital Israelita Albert Einstein, Sao Paulo, SP, BRA
²⁸Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
²⁹Democritus Thrace Univ., School of Medicine, Alexandroupolis, GRC
³⁰MDS Unit, DMSC, AOU Careggi, University of Florence, Firenze, Italy
³¹Myelodysplastic Syndromes Research Group, Josep Carreras Leukaemia Research Institute, ICO-Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain
³²University Leipzig Medical Center, Leipzig, Germany
³³Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria
³⁴Institute of Hematology "Sèragnoli", IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
³⁵Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
³⁶Division of Hematology-Oncology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan
³⁷Department of Pathology and Tumor Biology, Kyoto University Graduate School of Medicine, Sakyoku, KYO, Japan
³⁸Laboratory of Hematology, Université Paris Cité and Assistance Publique-Hôpitaux de Paris. Centre, Hôpital Cochin, Paris, France
³⁹Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Nijmegen, Netherlands
⁴⁰Department of Hematology and Genetics Unit, University Hospital La Fe, Valencia, Spain
⁴¹Howard Hughes Medical Institute, Boston, MA
⁴²Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
⁴³University of California, San Diego, La Jolla, CA
⁴⁴Stanford Cancer Center, Stanford University, Stanford, CA
⁴⁵Heinrich-Heine-Universitat, Dusseldorf, DEU
⁴⁶Department of Molecular Medicine, University of Pavia, Piazzale Golgi 2, Italy
⁴⁷University of Pavia, Pavia, Italy
⁴⁸Division of Rheumatology, Department of Medicine, NYU Grossman School of Medicine, New York

Elisabetta Sauta, PhD^1*, Matteo Zampini, PhD^1*, Daniele Dall'Olio, PhD^2*, Claudia Sala, PhD^2*, Gabriele Todisco, MD^1*, Erica Travaglino, BS^1*, Luca Lanino, MD³, Cristina Astrid Tentori, MD^1*, Giulia Maggioni, MD^1*, Saverio D'Amico, MSc^1*, Gianluca Asti, MSc^1*, Lorenzo Dall'Olio, PhD^4*, Ettore Mosca, PhD^5*, Marta Ubezio, MD^1*, Alessia Campagna^1*, Elena Riva, BSc^1*, Marilena Bicchieri, PhD^1*, Victor Savevski, MEng^1*, Armando Santoro, MD^6,7*, Shahram Kordasti, MD, PhD⁸, Valeria Santini, MD⁹, Maria Diez-Campelo, MD, PhD^10*, Anne Sophie Kubasch, MD^11*, Uwe Platzbecker, MD¹², Pierre Fenaux, MD, PhD¹³, Lin Pierre Zhao, MD^13*, Amer M. Zeidan, MBBS, MHS¹⁴, Torsten Haferlach, MD, PhD¹⁵, Gastone Castellani, PhD^2* and Matteo Giovanni Della Porta, MD^1,16*

¹Humanitas Clinical and Research Center, IRCCS, Rozzano, Italy
²University of Bologna, Bologna, Italy
³Humanitas Clinical and Research Center, IRCCS, Rozzano, Milano, Italy
⁴Data Science and Bioinformatics Laboratory, IRCCS Institute of Neurological Sciences of Bologna, Bologna, Italy
⁵Institute of Biomedical Technologies, National Research Council (CNR), Segrate, ITA
⁶Humanitas Cancer Center, Rozzano, Mi, Italy
⁷Humanitas University, Pieve Emanuele and IRCCS Humanitas Research Hospital- Humanitas Cancer Center Rozzano, Milan, Italy
⁸King's College London, London, United Kingdom
⁹MDS Unit, DMSC, AOU Careggi, University of Florence, Firenze, Italy
¹⁰Hospital Universitario de Salamanca, Salamanca, Spain
¹¹Department of Hematology, Cellular Therapy, Hemostaseology and Infectious Diseases, University Medical Center Leipzig, Leipzig, Germany
¹²Medical Clinic and Policlinic 1, Hematology and Cellular Therapy, University Hospital Leipzig, Leipzig, Germany
¹³Saint Louis hospital APHP, Paris, France
¹⁴Section of Hematology, Department of Internal Medicine, Yale School of Medicine and Yale Cancer Center, New Haven, CT
¹⁵MLL Munich Leukemia Laboratory, Munich, Germany
¹⁶Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy

Dicte Træden, BA^1*, Morten Tulstrup, MD^2,3*, Morten Munk Johansen^4*, Andreas Due Ørskov, MD^5*, Claus Marcher^6,7*, Klas Raaschou-Jensen, MD⁸, Anne Stidsholt Roug, MD, PhD^9*, Marianne Tang Severinsen^10,11*, Bo Porse^12,13,14*, Kim Theilgaard-Mönch^15*, Jakob Jespersen^16*, Jack B. Cowland, PhD, MS^17*, Lene Sjö^18*, Mette Klarskov Andersen, MD, PhD^17*, Kirsten Grønbæk, MD, DMSc^2,19 and Jakob Werner Hansen^1*

¹Department of Hematology, Rigshospitalet, University of Copengen, Copenhagen, Denmark
²Biotech Research and Innovation Centre, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
³Department of Hematology, Rigshospitalet, Copenhagen, Denmark
⁴Department of Hematology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
⁵Department of Hematology, Zealand Univsersity Hospital, Roskilde, Denmark
⁶Department of Hematology, Odense University Hospital, Odense C, Denmark
⁷Department of Clinical Research, University of Southern Denmark, Odense, Denmark
⁸Department of Hematology, Odense Univsersity Hospital, Odense, Denmark
⁹Aarhus University Hospital, Aarhus, Denmark
¹⁰Department of Hematology, Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, Denmark
¹¹Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
¹²University of Copenhagen, Copenhagen N, Denmark
¹³Biotech Research and Innovation Center (BRIC), University of Copenhagen, Copenhagen, Denmark
¹⁴The Finsen Laboratory, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
¹⁵Rigshospitalet, Copenhagen, DNK
¹⁶Biotech Research and Innovation Center, University of Copenhagen, KøBenhavn N, DNK
¹⁷Department of Clinical Genetics, Centre of Diagnostic Investigations, Copenhagen University Hospital, Copenhagen, Denmark
¹⁸University of Copenhagen, Copenhagen, DNK
¹⁹Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Miao Miao^1*, Qingliang Teng^2*, Depei Wu¹, Zhongxing Jiang^3*, Songfu Jiang^4*, Fei Li^5*, Yang Liang, MD, PhD⁶, Zhongmin Maxwell Wang^7*, Baiyong Li^7*, Yu Xia^7* and Hongyan Tong, PhD^8*

¹The First Affiliated Hospital of Soochow University, Suzhou, China
²Taian City Central Hospital, Taian, China
³The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
⁴The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
⁵The First Affiliated Hospital of Nanchang University, Nanchang, China
⁶Sun Yat-sen University Cancer Center, Guangzhou, China
⁷Akeso Biopharma Inc., Zhongshan, China
⁸The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China

Juan Jose Rodriguez Sevilla^1*, Vera Adema^2*, Kelly S. Chien, MD³, Irene Ganan-Gomez, PhD, MSc^1*, Guillermo Montalban-Bravo, MD³, Samuel Urrutia, MD⁴, Joby Joseph^1*, Hui Yang, MD, PhD^3*, Gautam Borthakur, MD³, Nicholas J. Short, MD³, Ghayas C. Issa⁵, Tapan M. Kadia, MD³, Koichi Takahashi, MD, PhD³, Danielle E. Hammond, MD³ and Guillermo Garcia-Manero, MD⁶

¹Leukemia, MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houst, Houston, TX
³Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵The University of Texas MD Anderson Cancer Center, Houston, TX
⁶University of Texas MD Anderson Cancer Center, Houston, TX

Rami S. Komrokji, MD¹, Muhammad Ammad-ud-din, MD^1*, Najla H Al Ali, MS^1*, Zhuoer Xie, MD, MS¹, Onyee Chan, MD^1*, Andrew T. Kuykendall, MD¹, Seongseok Yun, MD, PhD¹, Alison R. Walker, MD, MPH, MBA¹, Jeffrey Lancet, MD¹, Eric Padron, MD¹ and David A Sallman, MD²

¹Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL
²H. Lee Moffitt Cancer Center, Tampa, FL

Guillermo Garcia-Manero, MD¹, Olatoyosi Odenike², Shaun Fleming^3*, Gail J. Roboz, MD⁴, Meagan Jacoby^5*, Ilona Cunningham, MBBS FRACP FRCPA⁶, Karl-Anton Kreuzer^7*, Anoop K Enjeti, MBBS FRCPA MD MRCP⁸, Maria R. Baer, MD⁹, Rachel J. Cook, MD¹⁰, Joseph Jurcic, MD¹¹, Grace Ku^12*, Ying Zhou^13*, David Hoffman^13*, Jalaja Potluri¹³ and Jacqueline S. Garcia, MD¹⁴

¹University of Texas MD Anderson Cancer Center, Houston, TX
²The University of Chicago Medicine and Comprehensive Cancer Center, Chicago, IL
³Australasian Leukaemia and Lymphoma Group (ALLG), Melbourne, Australia
⁴Weill Cornell Medicine and The New York Presbyterian Hospital, New York, NY
⁵Washington University-School of Medicine, St. Louis, MO
⁶Haematology Department Concord Hospital, Concord and University of Sydney, Sydney, Australia
⁷Cologne University Hospital, Cologne, Germany
⁸Calvary Mater Hospital, Waratah, NSW, AUS
⁹Department of Medicine, University of Maryland School of Medicine, Baltimore, MD
¹⁰Oregon Health and Science University, Portland, OR
¹¹Columbia University Medical Center, New York, NY
¹²Genentech Inc., South San Francisco, CA
¹³AbbVie Inc, North Chicago, IL
¹⁴Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA

Jun Ho Jang^1*, Ji-Hyun Kim, MD, PhD^2*, Kyungah Lee^3*, Eugene Kim^4*, Hyojin Kim^4* and Fangyuan Wang^5*

¹Department of Hematology-Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of (South)
²Medical Affairs, Bristol Myers Squibb Korea, Seoul, Korea, Republic of (South)
³Market Access, Bristol Myers Squibb Korea, Seoul, Korea, Republic of (South)
⁴RWE, Syneos Health Korea, Seoul, Korea, Republic of (South)
⁵Data Analytics RWE, Syneos Health China, Beijing, China

Curtis A Lachowiez, MD¹, Georgios Asimomitis^2,3*, Elsa Bernard, PhD^2*, Ivory Tang^4*, Maria Creignou, MD^5*, Ulrich Germing^6*, Norbert Gattermann, MD⁷, Luca Malcovati, MD⁸, Mario Cazzola, MD⁹, Eva Hellstrom Lindberg, MD, PhD^10*, Elli Papaemmanuil¹¹ and Sanam Loghavi, MD¹²

¹Knight Cancer Institute, Oregon Health & Science University, Portland, OR
²Computational Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY
³Biomedical Systems Laboratory, Department of Mechanical Engineering, National Technical University of Athens, Athens, Greece
⁴Memorial Sloan Kettering Cancer Center, New York, NY
⁵Phase 1 Unit, Center for Clinical Cancer Studies, Karolinska University Hospital, Stockholm, Sweden
⁶Department of Hematology, Oncology and Clinical Immunology, Universitatsklinik Dusseldorf, Dusseldorf, Germany
⁷Klinik für Hämatologie, Onkologie und Klinische Immunologie, Universitätsklinikum Düsseldorf, Düsseldorf, Germany
⁸Department of Molecular Medicine, University of Pavia, Piazzale Golgi 2, Italy
⁹University of Pavia, Pavia, Italy
¹⁰Department of Medicine, Center for Hematology and Regenerative Medicine, Karolinska Institute, Stockholm, Sweden
¹¹Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY
¹²Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX

Angela Consagra^1*, Luca Lanino, MD², Najla H Al Ali, MS^3*, Luis E. Aguirre, MD⁴, Zhuoer Xie, MD, MS⁵, Onyee Chan, MD^3*, Gloria Andreossi^6*, Luca Rigodanza^6*, Alessandro Sanna, MD^7*, Marco Gabriele Raddi, MD^8*, Alison R. Walker, MD, MPH, MBA⁹, Andrew T. Kuykendall, MD³, Jeffrey Lancet, MD³, Eric Padron, MD^3,10, David A Sallman, MD^3,11, Francesco Restuccia, MD^12*, Alessandra Perego^13*, Marta Ubezio, MD^14*, Bruno Fattizzo, MD¹⁵, Marta Riva, MD^16*, Alessia Campagna^14*, Matteo Giovanni Della Porta, MD^14*, Valeria Santini, MD^17* and Rami S. Komrokji, MD³

¹MDS Unit, DMSC, AOU Careggi, University of Florence, Firenze, Italy
²Humanitas Clinical and Research Center, IRCCS, Rozzano, Milano, Italy
³Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL
⁴Dana-Farber Cancer Institute, Boston, MA
⁵H. Lee Moffitt Cancer Institute, Tampa, FL
⁶MDS UNIT, DMSC, Azienda Ospedaliero-Universitaria Careggi & University of Florence, Florence Italy, Florence, Italy
⁷Hematology, AOU Careggi, Florence, Italy
⁸Careggi Hospital, Florence, Italy
⁹H.Lee Moffitt Cancer Center & Research Institute, Tampa, FL
¹⁰Department of Malignant Hematology, H. Lee Moffitt Cancer Center, Tampa, FL
¹¹H. Lee Moffitt Cancer Center, Tampa, FL
¹²Presidio Ospedaliero, Pescara, Italy, Pescara, Italy
¹³Ospedale San Gerardo, ASST, Monza, Italy, Monza, ITA
¹⁴Humanitas Clinical and Research Center, IRCCS, Rozzano, Italy
¹⁵Department of Oncology and Onco-hematology, FONDAZIONE IRCCS CA' GRANDA OSPEDALE MAGGIORE POLICLINICO, Milano, Italy
¹⁶Department of Hematology, ASST Grande Ospedale Metropolitano Niguarda Cancer Center, Milano, Italy
¹⁷MDS UNIT, DMSC, Azienda Ospedaliero-Universitaria Careggi & University of Florence, Florence, Italy

Jorge Cortes, MD¹, Jay Yang, MD², Sangmin Lee, MD³, Shira N. Dinner, MD⁴, Eunice S. Wang, MD⁵, Maria R. Baer, MD⁶, William B. Donnellan, MD⁷ and Justin M. Watts, MD⁸

¹Georgia Cancer Center, Augusta University, Augusta, GA
²Karmanos Cancer Institute/ Department of Oncology, Wayne State University, Detroit, MI
³Weill Cornell Medical Center, New York, NY
⁴Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL
⁵Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY
⁶Department of Medicine, University of Maryland School of Medicine, Baltimore, MD
⁷Sarah Cannon Research Institute, Tennessee Oncology, Nashville, TN
⁸Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, MIAMI, FL

Guillermo Montalban-Bravo, MD¹, Elias Jabbour², Kelly S. Chien, MD¹, Gautam Borthakur, MD¹, Zeev Estrov, MD¹, Tapan M. Kadia, MD¹, Farhad Ravandi, MD, MBBS¹, Naveen Pemmaraju, MD¹, Graciela Nogueras-Gonzalez^3*, Heather Schneider, BSN, RN^4*, Rosmy John^4*, Meghan Anne Meyer, BSN, RN^4*, Hagop M. Kantarjian, MD⁴, Guillermo Garcia-Manero, MD⁵ and Xiao Qin DONG^6*

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²University of Texas M.D. Anderson Cancer Ctr., Houston, TX
³Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵The University of Texas MD Anderson Cancer Center, Houston, TX
⁶HOUSTON, TX

Ashwin Kishtagari, MBBS¹, Melissa A Fischer, PhD², Adam C. Seegmiller, MD^3*, Eric Padron, MD⁴, Thomas Cluzeau, MD, PhD⁵, Blanca Xicoy, MD^6*, Sylvain Garciaz^7*, Maria Diez-Campelo, MD, PhD^8*, Robert Wallace Corty^3*, Tamara K. Moyo, MD^9*, Theodore P Braun, MD, PhD¹⁰, Jason H. Mendler, MD¹¹, Mrinal M. Patnaik, MD, MBBS¹², Emily Ferguson Mason, MD, PhD^3*, Aaron C. Shaver, MD, PhD^3*, Michael Pfeilstoecker, MD^13*, Henry Durivage^14*, Nadjat Medeghri^14*, Barry Anderson^14*, Uwe Platzbecker, MD¹⁵, Pierre Fenaux, MD, PhD¹⁶, Valeria Santini, MD¹⁷ and Michael R. Savona, MD¹⁸

¹Division of Hematology & Oncology, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Franklin, TN
²Department of Medicine, Vanderbilt University Medical Center, Nashville, TN
³Vanderbilt University Medical Center, Nashville, TN
⁴Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL
⁵Nice University Hospital, Nice, Provence Alpes Cote d'Azur, France
⁶Institut Català d’Oncologia-Hospital Universitari Germans Trias i Pujol (HUGTP) -Josep Carreras Leukemia Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain
⁷Institut Paoli-Calmettes, Marseille, France
⁸University Hospital of Salamanca, Salamanca, Spain
⁹Atrium Health / Levine Cancer Institute, Charlotte, NC
¹⁰Division of Hematology & Medical Oncology, Oregon Health & Science University, Portland, OR
¹¹University of Rochester Medical Center, Rochester, NY
¹²Division of Hematology, Mayo Clinic, Rochester, MN
¹³Hanusch Hospital and Ludwig Boltzmann Institute for Hematology and Oncology, Wien, AUT
¹⁴Theradex Systems, Inc, Princeton, NJ
¹⁵University Leipzig Medical Center, Leipzig, Germany
¹⁶Hôpital Saint-Louis, Université Paris 7, Paris, France
¹⁷MDS Unit, DMSC, AOU Careggi, University of Florence, Firenze, Italy
¹⁸Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN

Junying Wu^1*, Yudi Zhang, PhD^1*, Tiejun Qin^2*, Zefeng Xu^1,3*, Shiqiang Qu^1,3*, Li Juan Pan^3*, Robert Peter Gale, MD⁴, Bing Li^1,3* and Zhijian Xiao^1,3,5*

¹State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, CAMS and PUMC, Tianjin, China
²MDS and MPN Centre, Hematologic Pathology Center, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
³MDS and MPN Centre, Institute of Hematology and Blood Diseases Hospital, CAMS and PUMC, Tianjin, China
⁴University of California, Los Angeles, Los Angeles, CA
⁵Hematologic Pathology Centre, Institute of Hematology and Blood Diseases Hospital, CAMS and PUMC, Tianjin, China

Guillermo Montalban-Bravo, MD¹, Nicholas J. Short, MD¹, Kelly S. Chien, MD¹, Yesid Alvarado Valero, MD¹, Naval Daver, MD¹, Gautam Borthakur, MD¹, Mahesh Swaminathan, MD¹, Abhishek Maiti, MD², Danielle E. Hammond, MD¹, Graciela Nogueras-Gonzalez^3*, Xuelin Huang, PhD^3*, Heather Schneider, BSN, RN^4*, Kristen Shelly^4*, Tapan M. Kadia, MD¹, Hagop M. Kantarjian, MD⁴ and Guillermo Garcia-Manero, MD⁵

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, MD Anderson Cancer Center, Houston, TX
³Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵The University of Texas MD Anderson Cancer Center, Houston, TX

Samuel Urrutia, MD¹, Kelly S. Chien, MD², Ziyi Li, PhD^3*, Gautam Borthakur, MD², Yesid Alvarado Valero, MD², Tapan M. Kadia, MD², Steven M. Kornblau, MD², Naval Daver, MD², Farhad Ravandi, MD, MBBS², Prithviraj Bose, MD⁴, Musa Yilmaz, MD^2*, Maro Ohanian, DO^2*, Rashmi Kanagal-Shamanna, MD⁵, Carlos E. Bueso-Ramos⁶, Hagop M. Kantarjian, MD² and Guillermo Garcia-Manero, MD⁷

¹Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴The University of Texas MD Anderson Cancer Center, Houston, TX
⁵Hematopathology, MD Anderson Cancer Center, Houston, TX
⁶Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁷University of Texas MD Anderson Cancer Center, Houston, TX

Hsin-Yu Lu^1*, Wan Hsuan Lee^1,2,3*, Chien-Chin Lin, MD, PhD^1,4*, Cheng-Hong Tsai, MD^1,5*, Feng-Ming Tien^1,3*, Min Yen Lo, MD^1,3,6*, Mei-Hsuan Tseng^7*, Yuan-Yeh Kuo^7*, Shan-Chi Yu^8*, Ming-Chih Liu^8*, Chang-Tsu Yuan, MD^9*, Yi-Tsung Yang^1,2,3*, Ming-Kai Chuang, MD^1,4*, Jih-Luh Tang, MD^1,10, Hsun-I Sun, MD^7*, Yi-Kuang Chuang^7*, Hsin-An Hou, M.D.; Ph.D.¹, Hwei-Fang Tien, MD, PhD^1,11 and Wen-Chien Chou, MD, PhD^1,4

¹Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
²Department of Internal Medicine, National Taiwan University Hospital, Hsin-Chu Branch, Hsinchu, Taiwan
³Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
⁴Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan
⁵Department of Medical Education and Research, National Taiwan University Hospital Yunlin Branch, Yunlin, Taiwan
⁶Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, Yunlin, Taiwan
⁷Tai-Chen Cell Therapy Center, National Taiwan University, Taipei, Taiwan
⁸Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan
⁹Department of Pathology, National Taiwan University Hospital Cancer Center Branch, Taipei, Taiwan
¹⁰National Taiwan University Hospital Cancer Center Branch, Taipei, Taiwan
¹¹Department of Internal Medicine, Far-Eastern Memorial Hospital, New Taipei, Taiwan

Eric Kuo, MD^1,2, Veronica Santiago^2*, Kailee Tanaka^1,2*, Vikram Puram, MD^1*, Crystal Zhou^1,2*, Jesse W. Tai, MS, BS¹, Gabriel N. Mannis^1,3, Ravi Majeti, MD^1,2,4 and Tian Y. Zhang, MD, PhD^1,2

¹Division of Hematology, Department of Medicine, Stanford University, Stanford, CA
²Stanford Cancer Institute, Stanford, CA
³Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA
⁴Stanford University School of Medicine, Stanford, CA

Byunggyu Bae^1*, Jong-Mi Lee^1,2*, Hoon Seok Kim^1,2*, Ari Ahn^1,2*, Jin Jung^1,2*, Daehun Kwag^3*, Silvia Park^4*, Yonggoo Kim^1,2*, Myungshin Kim^1,2* and Yoo-Jin Kim³

¹Department of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)
²Catholic Genetic Laboratory Center, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)
³Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)
⁴Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, AL, South Korea

Hussain Alcassab^1*, Koji Sasaki, MD², Danielle E. Hammond, MD², Alex Bataller, MD, PhD^2*, David B Beck, MD, PhD^3*, Tapan M. Kadia, MD², Guillermo Montalban-Bravo, MD², Kelly S. Chien, MD², L. Jeffrey Medeiros, MD⁴, Hagop Kantarjian, MD⁵, Awdesh Kalia^1*, Manjunath Nimmakayalu^6*, Carlos E. Bueso-Ramos⁴, Guillermo Garcia-Manero, MD⁷ and Rashmi Kanagal-Shamanna, MD⁸

¹UT MD Anderson School of Health Professions, Houston, TX
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³Division of Rheumatology, Department of Medicine, NYU Grossman School of Medicine, New York
⁴Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵The University of Texas MD Anderson Cancer Center, Houston, TX
⁶MDACC School of Health Professions, Houston, TX
⁷University of Texas MD Anderson Cancer Center, Houston, TX
⁸Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX

Samuel G Cockey^1*, Hailing Zhang, MD^2*, Mohammad Omar Hussaini, MD^2*, Ling Zhang, MD², Lynn C. Moscinski, MD², Ethan Yang^3* and Jinming Song, MD, PhD^2*

¹University of South Florida Health Morsani College of Medicine, Tampa, FL
²Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
³Berkeley Preparatory School, Tampa, FL

Casey L. O'Connell, MD¹, Maria R. Baer, MD^2,3, Vu H. Duong, MD, MS^2,3, Andreas Due Ørskov, MD, PhD^4,5,6,7*, Jakob Werner Hansen, MD, PhD^4,5,6*, Sunil Kumar Saini, PhD^8*, Denice Tsao-Wei, MS^9*, Justin Cheng^10*, Peter A. Jones, PhD, DSc^11* and Kirsten Grønbæk, MD, DMSc^4,5,6,7

¹Jane Anne Nohl Division of Hematology, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA
²Department of Medicine, University of Maryland School of Medicine, Baltimore, MD
³University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD
⁴Department of Hematology, Rigshospitalet, Copenhagen, Denmark
⁵Biotech Research and Innovation Centre, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
⁶The Danish Stem Cell Center (Danstem), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
⁷Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
⁸Department of Health Technology, Section of Experimental and Translational Immunology, Technical University of Denmark, Kgs. Lyngby, AL, DNK
⁹Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles
¹⁰Keck School of Medicine of USC, Los Angeles, CA
¹¹Department of Epigenetics, Van Andel Institute, Grand Rapids, MI

Helen Shang, MD, MS¹, Claire Daniel, MD^2*, Michael J. Maranzano, MD³, Sarah Stettner, MD^1*, Daria Louise Gaut, MD⁴, Sophie Carlson, MD⁵, Yash Motwani, BS^6*, Alexandra M. Klomhaus, PhD^7*, Caspian H. Oliai, MD⁸, Gary J. Schiller, MD⁹ and Wanxing Chai-Ho, MD¹⁰

¹Department of Medicine, University of California Los Angeles, Los Angeles, CA
²Department of Medicine, University of California Los Angeles, Los Angeles
³Division of Hematology and Oncology, University of California, Los Angeles, Rancho Palos Verdes, CA
⁴Department of Medicine/Division of Hematology and Oncology,, University of California Los Angeles, Los Angeles, CA
⁵Department of Medicine/Division of Hematology and Oncology, University of California Los Angeles, Los Angeles, CA
⁶Department of Medicine Statistics Core, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA
⁷Department of Medicine Statistics Core, David Geffen School of Medicine, University of California Los Angeles, Los Angeles
⁸Department of Medicine/Division of Hematology and Oncology, UCLA Medical Center, Los Angeles, CA
⁹Division of Hematology and Oncology, University of California, Los Angeles, Los Angeles, CA
¹⁰Department of Medicine/Division of Hematology and Oncology, University of California, Los Angeles, Los Angeles, CA