Yi Zhang^1*, Kankan Wang, MD, PhD^2,3*, Jiacheng Lou^4*, Yabin Liu^5*, Peng Jin^6*, Yun Tan^7*, Huan Song^8*, Wen Jin^2*, Fangyi Dong^2*, Shishuang Wu^6* and Hai Fang^9*

¹Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China
²Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
³Shanghai Jiaotong University School of Medicine, Shanghai, Shanghai, CHN
⁴Shanghai Institute of Hematology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
⁵Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, Nati, Shanghai, CHN
⁶Shanghai Institute of Hematology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, CHN
⁷Shanghai Institute of Hematology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, SHANGHAI, CHN
⁸Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, CHN
⁹State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Ruij, Shanghai, CHN

Bilal Malik, PhD^1*, Nunki Hassan, PhD^2* and Jenny Y. Wang, PhD³

¹Kolling institue, University of Sydney, St Leonards, Sydney, NSW, Australia
²Kolling Institute, University of Sydeny, St Leonards, Sydney, Australia
³Kolling Institute, University of Sydney, St Leonards Sydney, NSW, AUS

Martha M. Zarou, PhD^1*, Kevin Rattigan, PhD^2*, Daniele Sarnello^2*, Amy Dawson, PhD^2*, Karen Dunn^3*, Mhairi Copland, PhD, MBBChir, FRCP, FRCPath³, David Sumpton, PhD^4*, Alexei Vazquez, PhD^4* and G. Vignir Helgason, PhD²

¹Wolfson Wohl Cancer Research Centre, School of Cancer Sciences, University of Glasgow, Glasgow, SCO, United Kingdom
²Wolfson Wohl Cancer Research Centre, School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom
³Paul O’Gorman Leukaemia Research Centre, School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom
⁴Cancer Research UK Beatson Institute, Glasgow, United Kingdom

Shinichiro Matsui, MD, PhD^1,2*, Chihiro Ri, MD^3*, Lyndsey C. Bolanos, MBA, BSc^4*, Kwangmin Choi, PhD^4*, Asuka Shibamiya, MD, PhD^3*, Arata Ishii, MD, PhD^3*, Koji Takaishi, MD, PhD^3*, Nagisa Oshima-Hasegawa, MD, PhD^3*, Shokichi Tsukamoto, MD, PhD³, Yusuke Takeda, MD, PhD^3*, Naoya Mimura, MD, PhD^3,5, Koutaro Yokote, MD, PhD^2*, Daniel T. Starczynowski, PhD^4,6,7, Emiko Sakaida, MD, PhD^2,8 and Tomoya Muto, MD, PhD^3,9*

¹Department of Hematology, Chiba University Hospital, Chiba-Shi, Japan
²Department of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, Chiba, Japan
³Department of Hematology, Chiba University Hospital, Chiba, Japan
⁴Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁵Department of Transfusion Medicine and Cell Therapy, Chiba University Hospital, Chiba, Japan
⁶Department of Cancer Biology, University of Cincinnati, Cincinnati, OH
⁷Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
⁸Department of Hematology, Chiba University Hospital, Chiba City, Japan
⁹Division of Cancer RNA Research, National Cancer Center Research Institute, Tokyo, Japan

Naomi Kawashima, MD, PhD^1,2*, Dongxu Jiang, PhD², Daniel Vail, PhD^2*, Divya Jyoti Singh^2*, Xiaorong Gu, PhD^2*, Simon Schlanger, MS^2*, Carmelo Gurnari, MD¹, Yasuo Kubota, MD, PhD^1*, Brittany L Stewart^3*, Valeria Visconte, PhD¹, Jaroslaw P. Maciejewski, M.D., Ph.D., FACP¹ and Babal K. Jha, PhD, MPhil, MSc, BSc²

¹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
²Center for Immunotherapy & Precision Immuno-Oncology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH
³Center for Personalized Genetic Healthcare, Cleveland Clinic, Cleveland, OH

Huiqiao Chen^1*, He Huang^2,3,4* and Haowen Xiao^1,4*

¹Department of Hematology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
²Liangzhu Laboratory, Zhejiang University Medical Center, HangZhou, China
³Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
⁴Institute of Hematology, Zhejiang University, Hangzhou, China

Junyan Gao^1,2*, Yijun Wu^2*, Yuanyuan Tian^2*, De-Pei Wu³ and Shaoyan Hu, MD, PhD²

¹Department of pediatrics, Yangzhou University Affilated Hospital, Yangzhou, China
²Department of Hematology and Oncology, Children's Hospital of Soochow University, Suzhou, China
³Department of Hematology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China

Lola Badmus¹, Nicholas Achille^2*, Shubin Zhang^2* and Nancy J. Zeleznik-Le, PhD²

¹Department of Cancer Biology, Loyola University Chicago, Algonquin, IL
²Department of Cancer Biology, Loyola University Chicago, Maywood, IL

Zeinab Albadry M. Zahran, MD^1,2*, Xiaorong Gu, PhD^1*, Babal K. Jha, PhD, MPhil, MSc, BSc^1,3 and Yogenthiran Saunthararajah, MD¹

¹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
²Department of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt
³Center for Immunotherapy & Precision Immuno-Oncology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH

Abdula Maher^1* and Steven M. Chan, MD, PhD^1,2

¹Institute of Medical Science, University of Toronto, Toronto, ON, Canada
²Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada

Franziska Modemann^1,2*, Leoni Ramke^3*, Erkin Erdal^1,4*, Melanie Schoof^5,6*, Carolin Göbel^5*, Sina Neyazi^5,6*, Carsten Bokemeyer^1*, Jasmin Wellbrock^1*, Ulrich Schüller^5,6,7* and Walter Fiedler, MD⁸

¹Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Germany, Hamburg, Germany
²Mildred Scheel Cancer Career Center, University Cancer Center Hamburg, Germany, Hamburg, Germany
³Department of Otorhinolaryngology University Medical Center Hamburg-Eppendorf, Germany, Hamburg, Germany
⁴Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford OX37DQ, United Kingdom, Oxford, United Kingdom
⁵Research Institute Children's Cancer Center Hamburg, Hamburg, Germany, Hamburg, Germany
⁶Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, Hamburg, Germany
⁷Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, Hamburg, Germany
⁸Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Ana Catarina Menezes, PhD¹, Tao Zhen, PhD^1*, Derek E. Gildea, PhD^2*, Tyra G. Wolfsberg, PhD^2*, Nisc Comparative Sequencing Program^3* and Paul Pu Liu, MD, PhD¹

¹Oncogenesis and Development Section, National Human Genome Research Institute, NIH, Bethesda, MD
²Bioinformatics and Scientific Programming Core, National Human Genome Research Institute, NIH, Bethesda, MD
³NIH Intramural Sequencing Center (NISC), National Human Genome Research Institute, NIH, Bethesda, MD

Rongtao Xue, MD^1*, Junwei Lian, PhD^2*, Jinping He, MD^1*, Tong Lin, MD^1*, Yiyue Zhang, PhD^2* and Qifa Liu, MD³

¹Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China
²Southern China University of Technology, Guangzhou, China
³Nanfang Hospital, Southern Medical University, Guangzhou, China

Subhash Prajapati, PhD^1*, Cem Meydan^2*, Richard Dillon, PhD, MRCP, FRCPath^3*, Nicholas Dunham^1*, Hao Fan^4*, Jorge A Gandara^5*, Tak Lee^6*, Yaseswini Neelamraju⁷, Caroline Sheridan^6*, Zhenjia Wang^8*, Paul Zumbo^9*, Michael W. Becker, MD¹⁰, Lars Bullinger¹¹, Martin Carroll, MD¹², Richard J D'Andrea, PhD, BSc¹³, Ross L Levine, MD¹⁴, Christopher Mason^6*, Ari M Melnick, MD¹⁵, Chongzhi Zang^16*, Stefan Bekiranov, PhD^1* and Francine E. Garrett-Bakelman, MD, PhD⁸

¹University of Virginia, Charlottesville, VA
²Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY
³Department of Medical and Molecular Genetics, King's College London, London, United Kingdom
⁴University of Virginia, Charlottesville
⁵Weill Cornell Medicine, New York
⁶Weill Cornell Medicine, New York, NY
⁷University of Virginia, Charlottesville, GA
⁸University of Virginia School of Medicine, Charlottesville, VA
⁹Department of Physiology, Biophysics and Systems Biology, Weill Cornell Medicine, New York, NY, USA, New York
¹⁰Univ. of Rochester Medical Center, Rochester, NY
¹¹Department of Internal Medicine III, University of Ulm, Germany, Berlin, DEU
¹²Division of Hematology/Oncology, Department of Medicine, The Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA
¹³Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA, Australia, Adelaide, SA, AUS
¹⁴Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
¹⁵Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY
¹⁶Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA, Charlottesville

Gandhar Datar, BS¹, Archish Anand^1*, Marwa Sadek^2*, Evdokiia Potolitsyna^1*, Christina Dollinger^1*, English Laserna^1*, Lorenzo Brunetti, MD^3*, Nidhi Sahni^2*, Joshua Riback^1* and Margaret Goodell, PhD⁴

¹Baylor College of Medicine, Houston, TX
²The University of Texas MD Anderson Cancer Center, Houston, TX
³Clinica di Ematologia, Azienda Ospedaliero Universitaria delle Marche, Ancona, Italy
⁴Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX

Rasoul Pourebrahim, MD, PhD^1*, Shayaun Khazaei, BS^2*, Lauren B. Ostermann, BSc^2*, Ran Zhao, MS^2*, Muharrem Muftuoglu, MD² and Michael Andreeff, MD PhD³

¹Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Missouri City, TX
²Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX

Ashok Kumar Jayavelu, PhD.^1,2*, Maithreyan Kuppusamy, PhD^1,2, Lavanya Mokada Gopal, PhD^1,3*, Joris Frenz^1,2*, Matthias Mann^4*, Noelle Jung^1,2* and Andreas Kulozik, MD, PhD^5,6

¹German Cancer Research Center (DKFZ), Heidelberg, Germany
²Hopps Children's Cancer Center (KiTZ), Heidelberg, Germany
³Hopps Children's Cancer Center (KiTZ), Heidleberg, Germany
⁴Max-Planck Institute For Biochemistry, Martinsried, DEU
⁵Hopp-Kindertumorzentrum Heidelberg (KiTZ), Heidelberg, DEU
⁶Dept. of Pediatric Oncology and Hematology, Heidelberg, DEU

Helong Gary Gary Zhao, PhD¹, Kent Johnson^2*, Tony Pomicter, MS^3*, Briana Bates, MS^1*, Benjamin Bateman, BS^1*, Jonathan Ahmann^1*, Jenna Bishop^1*, Dongqing Yan^4*, Greg Lee^2*, Torsten Haferlach, MD, PhD⁵, Weiquan Zhu^6*, Shannon Odelberg^6* and Michael Deininger, MD, PhD^1,7

¹Versiti Blood Research Institute, Milwaukee, WI
²University of Utah, Salt Lake City, UT
³The University of Utah, Salt Lake City, UT
⁴Huntsman Cancer Institute, 4270, Salt Lake City, UT
⁵MLL Munich Leukemia Laboratory, Munich, Germany
⁶University of Utah, Salt Lake City
⁷Division of Hematology and Hematologic Malignancies, University of Wisconsin Milwaukee, Milwaukee, WI

Amy Wang, BA^1,2, Lin Han, PhD^1,3, Benjamin Braun^1,3*, Caroline Pitton^1,3*, Johann-Christoph Jann, MD^1,3* and Zuzana Tothova, MD, PhD^1,3

¹Cancer Program, Broad Institute, Cambridge, MA
²Department of Medical Oncology, Dana-Farber Cancer Institute, Kirkland, WA
³Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA

Chia Sharpe, PhD¹, Mariah Johnson, PhD^2*, Sydney Fobare, PhD³, Ola A. Elgamal, PhD¹, Bonnie K. Harrington, DVM^4*, Allison Mustonen^2*, Kinsey Bryant^1*, Carolyn Cheney, BS^1*, James R. Lerma^1*, Jean Truxall^2*, Casie Furby^1*, Marissa Long^1*, Kaytlynn Fyock^1*, Alan Shih, MD, PhD⁵, Ross L Levine, MD⁶, Erin K. Hertlein, PhD¹ and John C. Byrd, MD¹

¹Department of Internal Medicine, University of Cincinnati, Cincinnati, OH
²The Ohio State University, Columbus, OH
³Medical Scientist Training Program, The Ohio State University, Columbus, OH
⁴Michigan State University, East Lansing, MI
⁵Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
⁶Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY

Nainita Roy Bhowmick^1*, Iryna Berezniuk^2*, Takamitsu Hattori^3,4*, Sohini Chakraborty, PhD^1*, Alexis Corrado^3*, Akiko Koide^5,6*, Shohei Koide^7* and Christopher Y. Park, MD, PhD⁸

¹NYU Langone School of Medicine, New York, NY
²New York University Grossman School of Medicine, New York, NY
³NYU Grossman School of Medicine, Laura and Isaac Perlmutter Cancer Center, New York, NY
⁴Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York
⁵Perlmutter Cancer Center At NYU Langone Health, New York, NY
⁶Department of Medicine, NYU Grossman School of Medicine, New York
⁷NYU Grossman School of Medicine, Department of Biochemistry and Molecular Pharmacology, New York
⁸Department of Pathology, NYU Langone School of Medicine, New York

Chun-Chin Chen^1*, Angelika Amon^2*, Michael Hemann^2* and Robert Grant Rowe^3,4

¹Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA
²David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA
³Pediatric Hematology-Oncology, Boston Children's Hospital, Boston, MA
⁴Dana-Farber Boston Children’s Cancer and Blood Disorders Center, Boston, MA

Jiexin Zheng, MBBS, MA, MRCP^1*, Findlay Bewicke-Copley, PhD, MSc, BSc^2*, Carlo Vermeulen^3,4*, Pedro Casado, PhD^1*, Fadimana Kaya, MSc, BSc^5*, Jonas Demeulemeester^6*, Molly Guscott^1*, Szilvia Krizsán^7*, Sam Benkwitz-Bedford^8*, Farideh Miraki-Moud, PhD^9*, Janet Matthews^10*, Marianne Grantham^11*, Doriana Di Bella^2*, John G. Gribben, MD, DSc¹², James Cavenagh^13*, Peter Van Loo^14,15,16*, Sarah McClelland^1*, Csaba Bödör, PhD^7*, Jean-Baptiste Cazier^8*, David Taussig, MD, PhD, FRCPath^17*, Dominique Bonnet, PhD¹⁸, Pedro R Cutillas, PhD^1,19, Jun Wang^1*, Jeroen De Ridder^3,4*, Jude Fitzgibbon, PhD^1,20* and Ana Rio-Machin, PhD^1*

¹Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom
²Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom
³Center For Molecular Medicine, University Medical Center, Utrecht University, Utrecht, Netherlands
⁴Oncode Institute, Utrecht, Netherlands
⁵Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, ENG, United Kingdom
⁶KU Leuven, Leuven, BEL
⁷HCEMM-SU Molecular Oncohematology Research Group, Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary
⁸Centre for Computational Biology, Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom
⁹Acute Leukaemia Team, Institute of Cancer Research, London, United Kingdom
¹⁰Queen Mary University of London, London, United Kingdom
¹¹Barts Health NHS Trust, London, United Kingdom
¹²Barts Cancer Institute, Queen Mary University of London, London, United Kingdom
¹³Department of Haemato-Oncology, St Bartholomew's Hospital, Barts Health NHS Trust, London, United Kingdom
¹⁴Cancer Genomics Laboratory, The Francis Crick Institute, London, United Kingdom
¹⁵Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston
¹⁶Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston
¹⁷The Institute of Cancer Research, Sutton, United Kingdom
¹⁸Haematopoietic Stem Cell Lab, The Francis Crick Institute, London, United Kingdom
¹⁹The Alan Turing Institute, London, United Kingdom
²⁰AstraZeneca, Waltham, MA

Vanessa C. Arfelli, PhD^1,2,3*, Werner Schmitz, PhD^4*, Martin E. Kirmaier, MSc^1,5*, Enric Redondo Monte, PhD^1,2,3*, Paul Kerbs, PhD^1,2,3*, Monica Cusan, MD¹, Sebastian Theurich, MD^1,6*, Christian Wichmann, MD^7* and Philipp A. Greif, MD^1,2,3

¹Department of Medicine III, University Hospital, LMU Munich, Munich, Germany
²German Cancer Research Center (DKFZ), Heidelberg, Germany
³German Consortium for Translational Cancer Research (DKTK), Partner Site Munich, Munich, Germany
⁴Department of Biochemistry and Molecular Biology, Theodor Boveri Institute, Biocenter, University of Würzburg, Würzburg, Germany
⁵Cancer- and Immunometabolism Research Group, LMU Gene Center, Munich, Germany
⁶Cancer- and Immunometabolism Research Group, Gene Center, LMU Munich, Munich, Germany
⁷Division of Transfusion Medicine, Cell Therapeutics and Haemostaseology, University Hospital, LMU Munich, Munich, Germany

Emma E. Uible, BS^1,2, Kwangmin Choi, PhD^3*, Kathleen Hueneman, MBA^3*, Lyndsey C. Bolanos, MBA, BSc^3*, Kenneth Greis, PhD^4* and Daniel T. Starczynowski, PhD^3,5,6,7

¹Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital, Cincinnati, OH
²Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH
³Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁴University of Cincinnati College of Medicine, Cincinnati, OH
⁵Department of Cancer Biology, University of Cincinnati, Cincinnati, OH
⁶Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
⁷Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH

Yüksel Filik^1,2*, Karin Bauer, PhD^1,2* and Peter Valent, MD^1,2

¹Ludwig Boltzmann Institute for Hematology and Oncology, Vienna, Austria
²Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria

Jana M Ellegast, MD^1,2, Gabriela Alexe, PhD^1,2*, Subha Baniya^1,3*, Amanda Hamze^1*, Audrey Taillon^1*, Biniam Adane, PhD^1*, Amy Saur Conway^1*, Tinghu Zhang, PhD^4*, Nathanael S Gray, PhD^4*, Scott A Armstrong, MD, PhD^1,5 and Kimberly Stegmaier, MD^1,2,5

¹Pediatric Oncology, Dana-Farber Cancer Institute, Boston
²The Broad Institute of MIT and Harvard, Cambridge
³Memorial Sloan Kettering Cancer Center, New York
⁴Chem-H and Stanford Cancer Institute, Stanford
⁵Boston Children's Hospital, Boston

Ashley E. Cochran, PhD^1*, Aishlin Hassan, MSc^1*, Kathleen Hueneman, MBA^1*, Kwangmin Choi, PhD^1* and Daniel T. Starczynowski, PhD^1,2,3,4

¹Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
²University of Cincinnati College of Medicine, Cincinnati, OH
³Department of Cancer Biology, University of Cincinnati, Cincinnati, OH
⁴Cancer Center, University of Cincinnati, Cincinnati, OH