Kelsey D Sack, MD, PhD^1,2,3, Nathan Eaton, PhD^4*, Maneli Doroudian Tehrani^4* and Robert Flaumenhaft, MD, PhD⁵

¹Division of Hemostasis and Thrombosis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Belmont, MA
²Division of Pulmonary and Critical Care, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA
³Division of Pulmonary and Critical Care, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
⁴Division of Hemostasis and Thrombosis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
⁵Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Boston, MA

Abigail Ajanel Gomez, MS, BS¹, Frederik Denorme, PhD, MSc², Irina Portier, PhD^3*, Mia Kowalczyk^4*, Sradha Rameshbhatt^3*, Yasuhiro Kosaka, PhD^1* and Robert A. Campbell, PhD^1,5,6,7,8

¹Molecular Medicine Program, University of Utah, Salt Lake City, UT
²Department of Neurology, Division of Vascular Neurology, University of Utah, Salt Lake City, UT
³University of Utah, Salt Lake City, UT
⁴Univeristy of Utah, Salt Lake City, UT
⁵University of Utah School of Medicine, Salt Lake City, UT
⁶Department of Medicine, Division of General Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT
⁷Department of Pathology, University of Utah, Salt Lake City, UT
⁸Department of Internal Medicine, University of Utah, Salt Lake City, UT

Livia Stanger^1*, Pooja Yalavarthi^1*, Sylviane Lambert^1*, Andrew Rickenberg^1*, Krista Goerger^1*, Devin Gilmore^1*, Bjorn Dahlof^2*, Niklas Bergh^3* and Michael Holinstat, PhD¹

¹University of Michigan, Ann Arbor, MI
²University of Gothenburg, Gothenburg, SWE
³University of Gothenburg, Gothenburg, Sweden

Anastasiia Masaltseva^1*, Mikhail A. Panteleev, PhD^1,2,3* and Dmitry Nechipurenko, PhD^1,2,3*

¹Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, Moscow, Russian Federation
²Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russian Federation
³Faculty of Physics, Lomonosov Moscow State University, Moscow, Russian Federation

Young Jun Shim, PhD^1*, Paresh P Kulkarni, MD, MBBS, PhD^1*, Ahmed Alarabi, PhD^1*, Maierdan Palihati, MD^1*, Anne K Hubben, MD^1,2 and Keith R. McCrae, MD^1,2

¹Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH
²Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH

Mariia Kumskova, MD, Gagan D. Flora, PhD^*, Manasa K. Nayak, PhD^*, Ivan Budnik, MD, PhD^*, Aditi Jain, PhD^*, Rakeshkumar B. Patel, PhD^*, Steven R. Lentz, MD, PhD and Anil K. Chauhan, PhD

University of Iowa, Iowa City, IA

Young Jun Shim, PhD^1*, Bal Krishan Sharma, PhD^2*, Yohei Hisada, PhD^3*, Nigel Mackman, PhD³, Joseph S, Palumbo, MD⁴, Claudia Diaz-Montero, PhD^5*, Alok A. Khorana, MD⁶ and Keith R. McCrae, MD¹

¹Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH
²Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH
³University of North Carolina At Chapel Hill, Chapel Hill, NC
⁴Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH
⁵Cleveland Clinic, Cleveland, OH
⁶CLEVELAND CLINIC - US, Cleveland, OH

Dana Huskens, PhD^1*, Lisa Nynke Van Der Vorm, PhD^2*, Joke Konings, PhD^2*, Nicholas Arce, PhD³, Mark Roest^1*, Philip G. De Groot, PhD^2*, Renhao Li, PhD³, Jasper A. Remijn, PhD^4* and Bas De Laat, MD, PhD²

¹Department of Platelet Pathophysiology, Synapse Research Institute, Maastricht, Netherlands
²Synapse Research Institute, Maastricht, Netherlands
³Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA
⁴Department of Clinical Chemistry, Meander Medical Center, Amersfoort, Netherlands

Angelica DaSilva, BS^1*, Joan D Beckman, MD, PhD², Maya Abdullah^3*, Elena Aronovich, PhD^1*, Aithanh Viet Nguyen^1*, Julia Nguyen^1* and David Wood^1*

¹University of Minnesota, Minneapolis, MN
²Department of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota Twin Cities, Minneapolis, MN
³University of Minnesota, Minneapolis

Livia Stanger^1*, Michael Holinstat, PhD², Sylviane Lambert^1*, Pooja Yalavarthi^1*, Niklas Bergh^3* and Bjorn Dahlof^4*

¹University of Michigan, Ann Arbor, MI
²Pharmacology, University of Michigan, Ann Arbor, MI
³University of Gothenburg, Gothenburg, Sweden
⁴University of Gothenburg, Gothenburg, SWE

Christopher S. Thom, MD, PhD¹, Patricia Ellen Davenport, MD^2*, Hossein Fazelinia^3*, Zhi-Jian Liu, MD, PhD, BSc^2*, Haorui Zhang^4*, Hua Ding^3*, Jennifer Roof^3*, Lynn Spruce^3*, Harry Ischiropoulos^3* and Martha Sola-Visner, MD²

¹Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA
²Division of Newborn Medicine, Boston Children's Hospital, Boston, MA
³Children's Hospital of Philadelphia, Philadelphia, PA
⁴Boston Children's Hospital, Boston, MA

Sean X Gu, MD, PhD^1*, Patrick G Gallagher, MD², Ayesha Butt, MD³, Vivian W Gu, PhD^4*, Kimberly Lezon-Geyda, PhD^5*, Vincent P Schulz, PhD^5*, Stephanie Prozora, MD⁶, Alfred I Lee, MD, PhD³, Natalia Neparidze, MD⁷, Noffar Bar, MD⁸, Kelsey Martin, MD³, Jennifer Cornell, MSN^6*, Giavanna Chirico, MMSc^3*, Raja Chakraborty, PhD^4*, Henry M Rinder, MD⁹, John Hwa, MD, PhD^4* and Robert D Bona, MD³

¹Department of Laboratory Medicine, Yale University School of Medicine, North Haven, CT
²Departments of Pediatrics, Pathology, and Genetics, Yale University School of Medicine, New Haven, CT
³Section of Hematology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT
⁴Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT
⁵Department of Pediatrics, Yale University School of Medicine, New Haven, CT
⁶Department of Pediatric Hematology & Oncology, Yale University School of Medicine, New Haven, CT
⁷Section of Hematology, Department of Internal Medicine, Yale School of Medicine, New Haven, CT
⁸Department of Internal Medicine, Section of Hematology, Yale University School of Medicine and Yale Cancer Center, Cheshire, CT
⁹Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT

Anh T.P. Ngo, PhD¹, Nate Levine^1*, Abigail E Skidmore^2*, Amrita Sarkar, PhD¹, Veronica Bochenek, BA^1*, Manuela Roggiani, PhD^3*, Mark Goulian, PhD^3*, Mortimer Poncz, MD^1,4 and Kandace Gollomp, MD^1,4

¹Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA
²Division of Hematology, Children's Hospital of Philadelphia, Mount Laurel, NJ
³Department of Biology, University of Pennsylvania School of Arts & Sciences, Philadelphia, PA
⁴Department of Pediatrics, University of Pennsylvania PSOM, Philadelphia, PA

Andreas Witzemann, BS^1*, Lisann Pelzl, PhD^1*, Nina Wolska, PhD^1*, Jan Zlamal^1,2*, Jean Amiral^3* and Tamam Bakchoul, MD PhD^1,4

¹Institute for Clinical and Experimental Transfusion Medicine, Medical Faculty, Tuebingen, Germany
²University Hospital of Tuebingen, Tuebingen, Germany
³Hyphen Biomed, Neuville Sur Oise, FRA
⁴Center for Clinical Transfusion Medicine GmbH, Tuebingen, Germany

Lu Wang, PhD^1*, Jialing Wang, PhD^2*, Jihong Li, MD^1*, Thomas Walz, PhD^2* and Barry S. Coller, MD¹

¹Laboratory of Blood and Vascular Biology, The Rockefeller University, New York, NY
²Laboratory of Molecular Electron Microscopy, The Rockefeller University, New York, NY

Shancy Jacob^1*, Marina Tistao, PhD^1*, Abigail Ajanel Gomez, MS, BS¹, Frederik Denorme, PhD, MSc^1,2, Yasuhiro Kosaka, PhD^1*, Bhanu Kanth Manne, PhD^1*, Li Guo, MD, PhD³, Robert A. Campbell, PhD^1,4,5, Matthew T. Rondina, MD^1,4,6,7,8 and Jesse W Rowley, PhD^1,6

¹Molecular Medicine Program, University of Utah, Salt Lake City, UT
²Department of Neurology, Division of Vascular Neurology, University of Utah, Salt Lake City, UT
³Bloodworks Research Institute, Hematology Division, University of Washington, Salt Lake City, UT
⁴Department of Pathology, University of Utah, Salt Lake City, UT
⁵Division of Hematology and Hematologic Malignancies, Department of Internal Medicine, University of Utah School of Medicine, University of Utah, Salt Lake City, UT
⁶Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT
⁷Molecular Medicine Program, Department of Internal Medicine, and Division of Hematology and Hematologic Malignancies, University of Utah, Salt Lake City, UT
⁸Department of Internal Medicine and Geriatric Research and Education Clinical Center, George E. Wahlen VAMC, Salt Lake City, UT

Quentin Kimmerlin^1*, Sylvie Moog^2*, Lea Mallo^2*, Catherine Strassel^2*, Carsten Janke^3,4* and Francois Lanza^2*

¹Experimental Hematology, Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland, Basel, Switzerland
²Université de Strasbourg, INSERM, EFS Grand-Est, BPPS UMR-S1255, FMTS, Strasbourg, France
³Institut Curie, PSL Research University, CNRS UMR3348, Orsay, France
⁴Université Paris Sud, Université Paris-Saclay, CNRS UMR3348, Orsay, France

Patrick Van Dreden, PhD^1,2, Loula Papageorgiou, MD^3*, Eleftheria Lefkou^1*, Despina Fotiou, MD, PhD^4*, Efstathios Kastritis, MD^4*, Evangelos Terpos, MD, PhD⁵, Aurelie Rousseau, PhD^6*, Michele Sabbah^7*, Matthieu Grusse^6*, Elisabeth Mbemba^1*, Ismail Elalamy, MD, PhD^8*, Meletios A. Dimopoulos^4,9 and Grigoris Gerotziafas^1*

¹Sorbonne Université, INSERM UMRS-938, Team "Cancer Vessels, Biology and Therapeutics", Group "Cancer - Angiogenesis - Thrombosis," Institut Universitaire de Cancérologie, Centre de Recherche Saint Antoine, Hôpital Saint Antoine, Assistance Publique - Hôpi, Paris, France
²Stago, Gennevilliers, France
³Interdisciplinary cancer course département, Gustave Roussy, Villejuif, FRA
⁴Department of Clinical Therapeutics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece
⁵Department of Clinical Therapeutics, National and Kapodistrian University of Athens, School of Medicine, Drosia, Attiki, Greece
⁶Department of Clinical Research, Diagnostica Stago,, Gennevilliers, France
⁷Sorbonne Université, INSERM UMRS-938, "Cancer Vessels, Biology and Therapeutics", Group "Cancer - Angiogenesis - Thrombosis," Institut Universitaire de Cancérologie, Centre de Recherche Saint Antoine, Hôpital Saint Antoine,, Paris, FRA
⁸Hopital Tenon, Paris, FRA
⁹Hematology and Medical Oncology, Department of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Athens, Greece

Yasuhiro Kosaka, PhD^1*, Shancy Jacob^1*, Jorge Di Paola, MD², Justyne Ross, PhD^3*, Kristy Lee, M.S., C.G.C^3*, Sean Tavtigian, PhD^4*, Alun Thomas, PhD^5*, Matthew T. Rondina, MD^6,7, Paul F. Bray, MD⁸ and Jesse W Rowley, PhD¹

¹Molecular Medicine Program, University of Utah, Salt Lake City, UT
²Department of Pediatrics, Washington University School of Medicine, St Louis, MO
³Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, NC
⁴4Department of Oncological Sciences and Huntsman Cancer Institute, University of Utah, Salt Lake City, UT
⁵Department of Internal Medicine and Division of Epidemiology, University of Utah, Salt Lake City, UT
⁶Molecular Medicine Program, Department of Internal Medicine, and Division of Hematology and Hematologic Malignancies, University of Utah, Salt Lake City, UT
⁷Department of Internal Medicine and Geriatric Research and Education Clinical Center, George E. Wahlen VAMC, Salt Lake City, UT
⁸Molecular Medicine Program, Department of Internal Medicine, Department of Pathology, and Division of Hematology and Hematologic Malignancies, University of Utah, Salt Lake City, UT

Limei MA, PhD^1*, Xianmin Wang^1*, Peng Xiang^1*, Qingqiu Chen^1*, Ying Zhao^2*, Moustapha Hassan, PhD² and Chao Yu^1*

¹Chongqing Medical University, Chongqing, China
²Karolinska Institutet, Stockholm, Sweden