Yunfei Chen^1*, Xu Yanmei^1*, Xuan Cao^1*, Feng Xue, MD^1*, Ting Sun^1*, Wei Liu^2*, Mankai Ju^1*, Rongfeng Fu^1*, Xiaofan Liu, MD^3*, Xinyue Dai^1*, Huiyuan Li^1*, Renchi Yang, MD¹ and Lei Zhang, MD^1,4

¹Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
²State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology& Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
³Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, Tianjin, China
⁴State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Tianjin Key Laboratory of Gene Therapy for Blood Diseases, CAMS Key Laboratory of Gene Therapy for Blood Diseases, Tianjin, China

Peng Zhao^1*, Zhuoyu An^2*, Haixia Fu, MD^2*, Daihong Liu^3*, Liping Dou^3*, Yi Liu^4*, Hui Liu^5*, Zhao Wang^6*, Yujun Dong^7*, Hongmei Jing^8*, Hebing Zhou^9*, Zhen-Ling Li^10*, Lihong Li^11*, Qiu-Sha Huang^1*, Jin Wu^2*, Yejun Wu^2*, Chen-Cong Wang^2*, Xiaolu Zhu, MD^12*, Qi Chen^2*, Yun He^2*, Kaiyan Liu, MD, PhD² and Xiaohui Zhang, MD, PhD^2*

¹Peking University People's Hospital, Peking University Institute of Hematology, Beijing, CHN
²Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China
³Chinese PLA General Hospital, Beijing, China
⁴The Sixth Medical Center of PLA General Hospital, Beijing, CHN
⁵Beijing Hospital, Beijing, China
⁶Beijing Friendship Hospital, Beijing, China
⁷Peking University First Hospital, Beijing, China
⁸Peking University Third Hospital, Beijing, China
⁹Beijing Luhe Hospital, Beijing, China
¹⁰China-Japan Friendship Hospital, Beijing,, Beijing, CHN
¹¹Beijing Tsinghua Changgeng Hospital, Beijing, China
¹²Peking University Institute of Hematology, Peking University People’s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China

Jasmin Sabrina Rast, MD^1*, Theresa Schramm, MSc^1*, Dino Mehic, MD^2*, Michelle Fuchs^3*, Michael Fillitz^4*, Cihan Ay, MD^2*, Ingrid Pabinger, MD⁵ and Johanna Gebhart, MD^1*

¹Department of Medicine I, Clinical Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria
²Department of Medicine I, Clinical Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, AUT
³Clinical Division of Haematology and Haemostaseology, Department of Medicine I, Medical University of Vienna, Vienna, Austria
⁴Hanusch Hospital Vienna, Vienna, Au, AUT
⁵Medical University of Vienna, Vienna, Austria

Marques Cindy^1*, Mickael Roussotte^2*, Guillaume Moulis^3*, Bernard Bonnotte, M.D, PhD^4*, Jean-Francois Viallard, MD PhD^5*, Nathalie Costedoat-Chalumeau^6*, Alban Deroux^7*, Pascal Sève^2*, Bertrand Godeau^8*, Matthieu Mahevas, MD, PhD^8* and Marc Michel^9*

¹Department of Internal Medicine, French Referral Centre for Adult Immune Cytopenia, Henri Mondor Hospital, AP-HP, UPEC University, Créteil, Créteil, France
²Department of Internal Medicine, Hospices Civils de Lyon, Lyon, Lyon, France
³Toulouse University hospital, Toulouse, France
⁴Faculty of Medicine - University Hospital of Dijon, Dijon, FRA
⁵Service Médecine Interne, Haut-Leveque Hospital, Pessac, France
⁶Service de médecine interne, APHP, Hôpital Cochin, Paris, France
⁷Service De MéDecine Interne, CHU Grenoble-Alpes, La Tronche, FRA
⁸Internal medicine department, Henri Mondor Hospital, APHP, Créteil, France
⁹Department of Internal Medicine, National Reference Center for Immune Cytopenias, Henri-Mondor University Hospital, Assistance Publique–Hôpitaux de Paris, Université Paris-Est Créteil, Creteil, France

Eduarda Grinsztejn, MD¹, Jaime A Perez, PhD^2* and Sherwin I DeSouza, MD^1*

¹1Department of Medicine, Hematology-Oncology Division, University Hospitals Seidman Cancer Center, Cleveland, OH
²University Hospitals Clinical Research Center, Cleveland, OH

Elena Monzón Manzano, PhD^1,2*, Maria Teresa Álvarez-Roman^1,2,3*, Paula Acuña^1,2*, Elena G Arias-Salgado, PhD^1,2*, Raquel Ramírez Martín, MD^2,4*, Maria Cristina Pascual Izquierdo, MD, PhD^5*, Maria Isabel Rivas Pollmar, PhD, MD^1,2*, Monica Martin Salces, PhD, MD^1,2*, Waleed Ghanima, MD, PhD^6,7,8, Víctor Jiménez-Yuste, MD, PhD^1,2,3* and Nora Butta, PhD^2,9*

¹Department of Haematology, Hospital Universitario La Paz, Madrid, Spain
²IdiPAZ, Madrid, Spain
³Faculty of Medicine, Universidad Autonoma de Madrid, Madrid, Spain
⁴Department of Geriatrics, Hospital Universitario La Paz, Madrid, Spain
⁵Servicio de Hematología, Hospital Universitario Gregorio Marañón, Instituto de Investigación Gregorio Marañón, Madrid, Madrid, ESP
⁶Østfold Hospital, Gralum, Norway
⁷Østfold Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway
⁸Østfold Hospital, Gralum, NOR
⁹Hospital Universitario La Paz, Madrid, Madrid, Spain

James B. Bussel, MD¹, Nichola Cooper, MD^2*, Waleed Ghanima, MD, PhD^3,4, Drew Provan^5*, Yoshiaki Tomiyama, MD, PhD⁶, Ming Hou^7*, Donald Arnold, MD⁸, Cristina Santoro^9*, Francesco Zaja, MD^10*, Barbara Lovrencic^11*, Mervyn Morgan^12*, Leron Lahav^13*, Michal Winograd^13*, Jennifer MacWhirter - DiRaimo^14*, Tom Bailey^15*, Moyra Aziz^16*, Roberto Abi Rached^16* and Caroline Kruse^17*

¹Weill Cornell Medicine, New York, NY
²Department of Inflammation and Immunity, Imperial College London, London, United Kingdom
³Østfold Hospital Trust, Kalnes, Norway
⁴University of Oslo, Oslo, Norway
⁵Barts and The School of Medicine and Dentistry, London, United Kingdom
⁶Osaka University Hospital, Osaka, Japan
⁷Qilu Hospital of Shandong University, Shandong, China
⁸McMaster University, Hamilton, ON, Canada
⁹University Hospital Policlinico Umberto I, Rome, Italy
¹⁰DSM, University of Trieste and Department of Hematology, Azienda Sanitaria Universitaria Giuliano-Isontina, Trieste, Italy
¹¹AIPIT aps – Italian Association of Immune Thrombocytopenic Purpura, Caprino, Veronese, Italy
¹²ITP Support Association, Bolnhurst, United Kingdom
¹³ITP Israel, the Israeli association of ITP, Ramat Hasharon, Israel
¹⁴Platelet Disorder Support Association, Ontario, Canada
¹⁵Adelphi Real World, Bollington, United Kingdom
¹⁶Novartis Pharma AG, Basel, Switzerland
¹⁷Platelet Disorder Support Association, Cleveland, OH

Yun He^1,2*, Haixia Fu, MD^3*, Xiaolu Zhu, MD^4*, Qiusha Huang, MD^5*, Qi Chen, MD^6*, Jin Wu, MD^5*, Yuxiu Chen^2*, Peng Zhao^7*, Kai-Yan Liu, MD, PhD² and Xiaohui Zhang, MD^2,8,9,10,11*

¹National Clinical Research Center for Hematologic Disease, Beijing, China;, Beijing, China
²Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China
³Peking University People’s Hospital, Peking University Institute of Hematology, Beijing, China., Beijing, China
⁴Peking University People’s Hospital,Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing, China
⁵Peking University People's Hospital, Beijing, CHN
⁶Peking University People’s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China
⁷Peking University People’s Hospital, Peking University Institute of Hematology, Beijing, China
⁸Collaborative Innovation Center of Hematology, Peking University, Beijing, China
⁹National Clinical Research Center for Hematologic Disease, Beijing, China
¹⁰Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China
¹¹Peking University People's Hospital, Beijing, China

Hirokazu Kashiwagi, MD^1*, Masataka Kuwana^2*, Mitsuru Murata, MD³, Naoki Shimada^4*, Toshiro Takafuta, MD⁵, Jun Yamanouchi, MD, PhD⁶, Hisashi Kato, MD, PhD⁷, Takaaki Hato, MD⁸ and Yoshiaki Tomiyama, MD, PhD⁷

¹Department of Blood Transfusion, Osaka University Hospital, Suita, Japan
²Department of Allergy and Rheumatology,, Nippon Medical School, Tokyo, JPN
³Center for Clinical Medical Research, International University of Health and Welfare, Narita, Japan
⁴Center for Basic Medical Research, International University of Health and Welfare, Otawara, JPN
⁵Hiroshima City Funairi Citizens Hospital, Hiroshima City, HIR, JPN
⁶Ehime University Grad. School of Med., Toon, JPN
⁷Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Japan
⁸Japanese Red Cross Ehime Blood Center, Matsuyama-Shi, EHI, JPN

Vinita Dhir, BSc^1,2, Caseng Zhang^2,3, Nick Barrowman, PhD^4*, Ewa Sucha, MSc^4*, Rachael F. Grace, MD⁵, John D. Grainger, MD, MRCP, FRPATH^6*, Nancy L Young, PhD^4* and Robert J. Klaassen, MD, FRCPC^1,2

¹Division of Hematology/Oncology, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada
²Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada
³Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada
⁴Children’s Hospital of Eastern Ontario Research Institute, Ottawa, Canada
⁵The Children's Hospital Corporation, Boston, MA
⁶Royal Manchester Children's Hospital, Pendlebury, GBR

Jie Yin, MD^*, Hong Tian^*, Xin Lv^*, Yun Li^*, Ziqiang Yu^* and Depei Wu

National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, China

Haixia Fu, MD^1*, Qiusha Huang^2*, Yun He^3,4*, Chen-Cong Wang^3*, Kaiyan Liu³ and Xiaohui Zhang^3*

¹Peking University People’s Hospital, Peking University Institute of Hematology, Beijing, Beijing, China
²Peking University People's Hospital, Beijing, China
³Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China
⁴Peking University People’s Hospital, Beijing, China

Fabiola Del Carpio-Cano^1*, Guangfen Mao, MD^1*, Lawrence E. Goldfinger, PhD, BS^2*, Jeremy Wurtzel^2*, Liying Guan, PhD^1*, Afaque Mohammad Alam, PhD^1*, Kiwon Lee^3*, Mortimer Poncz, MD^3* and Angara Koneti Rao, MBBS⁴

¹Sol Sherry Thrombosis Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA
²Cardeza Foundation for Hematologic Research, Division of Hematology, Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA
³Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA
⁴Sol Sherry Thrombosis Research Center and Hematology Division, Lewis Katz School of Medicine, Temple University, Philadelphia, PA

Fengjiao Han^1*, Qiuyu Guo^1*, Yun Wang^1*, Zihan Zhang^1*, Qi Feng^1*, Jun Peng^1*, Ming Hou^1*, Heyu Ni, MD, PhD, MSc² and Miao Xu, MD, PhD^1*

¹Shandong University/Qilu Hospital, Jinan, China
²Department of Physiology, University of Toronto, Toronto, Canada

Ghada Araji, MD^1*, Fatema Arafa, MD^1*, Ahmad Mustafa, MD^1*, Anisha Rajavel, DO^1*, Hamed Chehab, MD^1*, Muhammad Niazi, MBBS², Suzanne El-Sayegh, MD^1* and Liliane Deeb, MD^3*

¹Department of Internal Medicine, Northwell Health/Staten Island University Hospital, Staten Island, NY
²Department of Hematology and Oncology, Northwell Health/Staten Island University Hospital, Staten Island, NY
³Department of Gastroenterology, Northwell Health/Staten Island University Hospital, Staten Island, NY

Rajiv K. Pruthi, M.B.B.S.^1,2,3, Julie A Majerus, B.S.^3* and Dong Chen, MD, PhD⁴

¹Division of Hematology, Mayo Clinic, Rochester, MN
²Mayo Comprehensive Hemophilia Center, Mayo Clinic, Rochester, MN
³Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
⁴Division of Hematopathology, Mayo Clinic, Rochester, MN

Hilary Whitworth, MD, MSc¹, Elizabeth Andrews, BS^2*, Eric Thompson, BS^2*, Leslie Raffini, MD³, Bhavya S Doshi³ and Michele P. Lambert, MD, MTR¹

¹Division of Hematology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA
²Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA
³Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA

Amanda B. Grimes, MD^1,2, Rachael F. Grace, MD^3,4, Melissa J. Rose, DO⁵, Sanjay J. Shah, MBBS⁶, Shipra Kaicker, MD^7*, Carolyn Bennett, MD^8*, Michael Briones^9*, Taizo A. Nakano, MD¹⁰, Stephanie A. Fritch Lilla, MD¹¹, Jeffrey D. Lebensburger, DO, MSPH¹², Alexis A. Thompson, MD, MPH^13,14, Rukhmi Bhat, MD, MS^15,16, Rohith Jesudas, MBBS¹⁷, Michele P. Lambert, MD, MTR^18,19, Shelley E. Crary, MD, MS²⁰, Kerry Hege, MD²¹, Cathy A. Lee-Miller, MD^22*, Suvankar Majumdar, MBBChir^23*, James B. Ford, DO²⁴, Joshua J. Bies^25*, Vandy Black²⁶, John Fort^27*, Manpreet Kochhar, MD, MS^28*, Julia MW Wong, PhD, RD^29*, Bogdan Dinu^30*, Pei-Chi Kao^4,31*, Wendy B. London, PhD^31*, Jenny M. Despotovic, DO, MS³², Robert J. Klaassen, MD, FRCPC³³, Ellis J. Neufeld, MD¹⁷, Cindy Neunert, MD, MScs³⁴ and Kristin A. Shimano, MD³⁵

¹Texas Children’s Cancer and Hematology Center, Houston, TX
²Baylor College of Medicine, Houston, TX
³Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA
⁴Boston Children's Hospital, Boston, MA
⁵Nationwide Children’s Hospital, Columbus, OH
⁶Center for Cancer and Blood Disorders, Phoenix Children's Hospital, Phoenix, AZ
⁷Department of Pediatric Hematology Oncology, Weill Cornell Medicine, Komansky Children’s Hospital at New York Presbyterian, New York, NY
⁸Spark Therapeutics, Philadelphia, PA
⁹Children's Hospital of Atlanta, Atlanta, GA
¹⁰Children's Hospital Colorado, Denver, CO
¹¹Children's Minnesota, Minneapolis, MN
¹²University of Alabama at Birmingham, Birmingham, AL
¹³Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
¹⁴Division of Hematology, Children’s Hospital of Philadelphia, Philadelphia, PA
¹⁵Northwestern University Feinberg School of Medicine, Chicago, IL
¹⁶Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL
¹⁷St. Jude Children's Research Hospital, Memphis, TN
¹⁸Children's Hospital of Philadelphia, Philadelphia, PA
¹⁹Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
²⁰Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR
²¹Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN
²²University of Wisconsin School of Medicine and Public Health, American Family Children’s Hospital, Madison, WI
²³Children's National Medical Center, Washington, DC
²⁴University of Nebraska Medical Center, Omaha, NE
²⁵University of Nebraska Medical Center, Children's Hospital and Medical Center of Omaha, Omaha, NE
²⁶Novo Nordisk, Plainsboro, NJ
²⁷Department of Pediatrics, Division of Pediatric Hematology-Oncology, University of Florida College of Medicine, Gainesville, FL
²⁸The Warren Alpert Medical School at Brown University, Hasbro Children's Hospital, Providence, RI
²⁹Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, Brookline, MA
³⁰Texas Children's Cancer and Hematology Center, Houston, TX
³¹Dana-Farber Cancer Institute, Boston, MA
³²Agios Pharmaceuticals, Cambridge, MA
³³Division of Hematology/Oncology, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada
³⁴Morgan Stanley Children’s Hospital, New York, NY
³⁵UCSF Benioff Children's Hospital, San Francisco, CA

Emilie Vander Haar^1*, Courtney Abshier Ware^2*, Gwen Allen^3*, Róisín Armstrong^4*, Dawn Black^5*, Michael Bombara^4*, David Dhanraj^6*, Laura Lawrence^4*, Russell Miller^7*, Surabhi Nanda^8*, Michael J Paidas⁹, Kiran C Patki^4*, Vasilis Sitras^10*, Daniel Skupski^11*, Monte Swarup^12*, John Thorp^13*, Heidi Tiller^14*, Joanne Verweij^15* and James B. Bussel, MD¹⁶

¹Weill Cornell Medicine, New York-Presbyterian Hospital, New York
²Ohio State University Wexner Medical Center, Columbus, OH
³Zillan Clinical Research - Gardena, Los Angeles
⁴Rallybio Inc., New Haven, CT
⁵Javara Research Inc. - Dallas - PPDS, Dallas
⁶Wright State Physicians Obstetrics & Gynecology, Dayton
⁷Columbia University Irving Medical Center, New York
⁸St Thomas' Hospital, London, United Kingdom
⁹University of Miami, Miller School of Medicine, Miami, FL
¹⁰Oslo Universitetssykehus HF, Ullevål, Oslo, Norway
¹¹New York-Presbyterian-Queens, New York
¹²New Horizons Clinical Trials, LLC, Cincinnati
¹³University of North Carolina at Chapel Hill, Durham, NC
¹⁴University Hospital of North Norway, Tromso, NOR
¹⁵Leids Universitair Medisch Centrum, Leiden, Netherlands
¹⁶Weill Cornell, New York, NY

Suthesh Sivapalaratnam, MD, PhD^1*, Steve Austin, MD^2*, Ulrike Lorch, MD, FRCA, FFPM^3*, Thomas York, MD^3*, Andrew Want, MBBS, PhD, FRCOphth^3*, Ashley Gosnell, PA-C^4*, Prafull S. Gandhi, PhD^5*, Henrik Østergaard, PhD, MSc^5*, Erik Bjornson^5*, Tara O'Meara^4*, Benny Sorensen, MD, PhD⁴, Roger E.G. Schutgens, MD, PhD, MSc^6* and Catherine Rea, MD, PhD^5*

¹Queen Mary University of London, Blizard Institute, London, United Kingdom
²St. George's Hospital NHS Trust, London, GBR
³Richmond Pharmacology, London, United Kingdom
⁴Hemab Therapeutics, Cambridge, MA
⁵Hemab Therapeutics, Copenhagen, Denmark
⁶Center for Benign Hematology, Thrombosis and Hemostasis - Van Creveldkliniek, University Medical Center Utrecht, Utrecht, Netherlands

Waleed Ghanima, MD, PhD^1,2, Vickie McDonald, MD, PhD, FRPATH, MRCP^3*, Milica Putnik, PhD^4*, Brian Jamieson, MD⁵ and Stefan Rune Lethagen, MD, PhD^6*

¹Oslo University, Oslo, Norway
²Østfold Hospital, Gralum, NOR
³Barts Health NHS Trust, The Royal London Hospital, London, United Kingdom
⁴Swedish Orphan Biovitrum AB, Stockholm, Sweden
⁵Sobi, Inc., Durham, NC
⁶Swedish Orphan Biovitrum, Stockholm, SWE