-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

652A.O2.6 652. Multiple Myeloma: Clinical and Epidemiological: T Cell Redirecting Therapy Outcomes and Associated Complications Clinically Relevant Abstract

Symposia: Multiple Myeloma: Clinical and Epidemiological Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Biological therapies, Bispecific Antibody Therapy, Plasma Cell Disorders, Chimeric Antigen Receptor (CAR)-T Cell Therapies, Diseases, Therapies, Lymphoid Malignancies, Adverse Events, Minimal Residual Disease
Saturday, December 9, 2023: 9:30 AM-11:00 AM
Seaport Ballroom ABCD (Manchester Grand Hyatt San Diego)
Moderators:
Ruben Niesvizky, MD, Weill Cornell Medicine/New York Presbyterian Hospital and Roman Hajek, MD, University Hospital Ostrava
Disclosures:
Niesvizky: BMS/Celgene: Consultancy, Research Funding; Takeda: Consultancy, Honoraria, Research Funding; Janssen: Consultancy, Honoraria, Research Funding; GSK: Consultancy, Honoraria, Research Funding; Karyopharm: Consultancy, Honoraria, Research Funding; Pfizer: Consultancy, Honoraria, Research Funding; Sanofi: Consultancy, Honoraria; Regeneron: Consultancy, Honoraria, Research Funding. Hajek: AbbVie: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; GlaxoSmithKline: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Oncopeptides: Consultancy, Membership on an entity's Board of Directors or advisory committees; Sanofi: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Takeda: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Other: Support for attending meetings and/or travel, Research Funding; Novartis: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Bristol Myers Squibb: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Celgene: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Other: Support for attending meetings and/or travel, Research Funding; PharmaMar: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Amgen: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Other: Support for attending meetings and/or travel, Research Funding; Janssen: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Other: Support for attending meetings and/or travel, Research Funding.
The abstracts in this session investigate real world outcomes of T cell redirecting therapy including the clinical significance of minimal residual disease in this patient population, as well as serum and molecular biomarkers that may predict outcomes.
9:30 AM

Danai Dima, MD1,2, James A Davis, PharmD2,3*, Nausheen Ahmed, MD2,4, Aishwarya Sannareddy, MBBS5*, Hira Shaikh, MBBS2,6*, Zahra Mahmoudjafari, PharmD2,4*, Jack Khouri, MD1, Gurbakhash Kaur, MD, MA5, Christopher Strouse, MD2,6, Jason Valent, MD1, Larry D. Anderson Jr., MD, PhD5, Faiz Anwer, MD1,2, Al-Ola Abdallah, MD2,4 and Hamza Hashmi, MD2,3*

1Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
2US Myeloma Innovations Research Collaborative (USMIRC), Kansas City, KS
3Department of Hematology-Oncology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC
4Division of Hematologic Malignancies & Cellular Therapeutics, University of Kansas Cancer Center, Westwood, KS
5Division of Hematologic Malignancies and Cellular Therapy, Dept of Internal Medicine, Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX
6Division of Hematology, Oncology and Blood & Marrow Transplantation, Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA

9:45 AM

Darren Denjay Pan, MD1, Tarek H. Mouhieddine, MD2, Weijia Fu3*, Erin Moshier4*, Samir Parekh, MD1, Sundar Jagannath, MD1, Adriana C Rossi, MD, MSc1, Hearn Jay Cho, MD5, Joshua Richter, MD2, Larysa J Sanchez, MD1, Santiago Thibaud, MD1*, Cesar Rodriguez, MD1* and Shambavi Richard, MD1

1Department of Medicine, Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York
2Department of Medicine, Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
3Icahn School of Medicine at Mount Sinai, New York, NY
4Department of Population Health Science & Policy, Icahn School of Medicine at Mount Sinai, New York, NY
5Department of Medicine, Hematology and Medical Oncology, Tisch Cancer Institute, Tisch Cancer Institute, New York, NY

10:00 AM

Junia Vieira dos Santos, MD, PhD1*, David Melnekoff, MS1*, Adolfo Aleman, MPA2, Sherry Bhalla, PhD3*, Tarek H. Mouhieddine, MD2, Oliver Van Oekelen, MD, PhD2, Sridevi Rajeeve, MD4*, Bhaskar Upadhyaya, PhD5*, Yogita Ghodke-Puranik, PhD1*, Violetta Leshchenko, PhD6*, Adeeb Rahman, PhD7*, Shaked Afik, PhD7*, Hadas Lewinsky, PhD7*, Santiago Thibaud, MD5*, Hearn Jay Cho, MD8, Joshua Richter, MD2, Cesar Rodriguez, MD5*, Larysa Sanchez, MD2*, Adriana C Rossi, MD, MSc5, Shambavi Richard, MD5, Ajai Chari, MD9*, Sundar Jagannath, MD10, Samir Parekh, MD5 and Alessandro Lagana, PhD6

1Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
2Department of Medicine, Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
3Mount Sinai Hospital, New York, NY
4Mount Sinai, New York, NY
5Department of Medicine, Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York
6Icahn School of Medicine At Mount Sinai, New York, NY
7ImmunAI, New York, NY
8Department of Medicine, Hematology and Medical Oncology, Tisch Cancer Institute, Tisch Cancer Institute, New York, NY
9at the time that the work was performed, Mount Sinai School of Medicine, New York, NY
10Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York

10:15 AM

Aintzane Zabaleta1*, Noemi Puig, MD, PhD2, Maria Teresa Cedena Romero, MD, PhD3*, Jose J Perez4*, Cristina Moreno5*, Luis-Esteban Tamariz-Amador, MD5*, Paula Rodriguez Otero, MD, PhD6*, Veronica Gonzalez-Calle, MD, PhD2*, Lucia Lopez Corral, MD, PhD7*, Beatriz Rey-Búa4*, Borja Puertas Martínez4*, Fatima Miras8*, Jose Sanchez-Pina8*, Nieves Lopez8*, Joaquin Martinez-Lopez, MD, PhD8*, Maria Victoria Mateos, MD, PhD2, Jesus San-Miguel, MD, PhD5 and Bruno Paiva9*

1CIMA (Pamplona)Cancer Center Clinica Universidad de Navarra (CCUN), Centro de Investigacion Medica Aplicada (CIMA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), CIBER-ONC numbers CB16/12/00369 and CB16/12/00489, Pamplona, Spain
2Hospital Universitario de Salamanca, Instituto de Investigacion Biomedica de Salamanca (IBSAL), University of Salamanca, Salamanca, Spain
3Hospital Universitario 12 de Octubre, CIBER-ONC CB16/12/00369, CNIO, Madrid, Spain
4Hospital Universitario de Salamanca, Instituto de Investigacion Biomedica de Salamanca, Salamanca, Spain
5Cancer Center Clinica Universidad de Navarra (CCUN), Centro de Investigacion Medica Aplicada (CIMA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), CIBER-ONC numbers CB16/12/00369 and CB16/12/00489, Pamplona, Spain
6Cancer Center Clínica Universidad de Navarra (CCUN), CIMA, CIBERONC, IDISNA, Pamplona, Spain
7Instituto de Investigacion Biomedica de Salamanca (IBSAL), Centro de Investigación del Cáncer-IBMCC (USAL-CSIC), Hospital Universitario de Salamanca, Salamanca, Spain
8Hospital 12 de Octubre, Madrid, Spain
9Cancer Center Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada (CIMA), IDISNA, CIBER-ONC number CB16/12/00369 and CB16/12/00489, Pamplona, Spain

10:30 AM

Xiang Zhou1*, Vivien Wagner2*, Emilia Stanojkovska3*, Christine Riedhammer4*, Xianghui Xiao, MD5*, Mara John3*, Lukas Scheller6*, Umair Munawar7*, Seungbin Han8*, Johannes M Waldschmidt, MD9,10, Max S. Topp, MD11*, Johannes Duell, MD12*, Hermann Einsele, MD, PhD5*, Angela Riedel, PhD3*, Martin Kortüm, MD13* and Leo Rasche, MD5*

1Department of Internal Medicine II, University Hospital Wuerzburg, WüRzburg, Germany
2University of Wurzburg, Wurzburg, Germany
3Mildred Scheel Early Career Center for Cancer Research, University Hospital Wurzburg, Wurzburg, Germany
4Department of Internal Medicine II, University Hospital Wuerzburg, Würzburg, Germany
5Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany
6University Hospital Wurzburg, Wuerzbzrg, DEU
7Department of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany
8University Hospital Wurzburg, Wuerzburg, DEU
9Department of Internal Medicine II, University of Wuerzburg Medical Center, Wuerzburg, Germany
10Department of Medical Oncology, Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Boston, MA
11Medizinische Klinik Und Poliklinik II Universitätsklinikum Wurzburg, Wurzburg, Germany
12Department of Internal Medicine II, Hematology and Oncology, University Hospital Wuerzburg, Wuerzburg, Germany
13Mayo Clinic In Arizona, Scottsdale, AZ

10:45 AM

Michel Delforge1*, Krina K. Patel, MD, MSc2, Laurie Eliason, MPH3*, Devender Dhanda, PhD3*, Ling Shi, PhD4*, Shien Guo, PhD4*, Thomas S. Marshall, PharmD3*, Bertrand Arnulf, MD, PhD5, Michele Cavo, MD6*, Ajay K. Nooka, MD, MPH7, Salomon Manier, MD, PhD8, Natalie S. Callander, MD9, Sergio A. Giralt, MD, FACP10, Hermann Einsele, MD, PhD11*, Sikander Ailawadhi12, Mihaela Popa-McKiver, MD, PhD3*, Mark Cook, MBChB, PhD13 and Paula Rodriguez Otero, MD, PhD14*

1University Hospital Leuven, Leuven, Belgium
2The University of Texas MD Anderson Cancer Center, Houston, TX
3Bristol Myers Squibb, Princeton, NJ
4Evidera, Bethesda, MD
5Hôpital Saint-Louis, APHP, Université Paris cite, Paris, France
6Seràgnoli Institute of Hematology, Bologna University School of Medicine, Bologna, Italy
7Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA
8Centre Hospitalier Universitaire de Lille, Lille, France
9University of Wisconsin Carbone Cancer Center, Madison, WI
10Memorial Sloan Kettering Cancer Center, New York, NY
11Medizinische Klinik und Poliklinik II, Uniklinikum Würzburg, Würzburg, Germany
12Mayo Clinic, Jacksonville, FL
13Celgene International Sàrl, a Bristol-Myers Squibb Company, Boudry, Switzerland
14Clinica Universidad de Navarra, Pamplona, Spain

*signifies non-member of ASH