Francisco Marchi¹, Marieke Landwehr^1*, Fernando Sckaff^2*, Xueyuan Cao, PhD^3,4*, Raul C. Ribeiro, MD⁵, Jeffrey E. Rubnitz, MD, PhD^5,6, Alan S Gamis, MD, MPH⁷, E. Anders Kolb, MD⁸, Richard Aplenc, MD, PhD^9,10, Stanley Pounds, PhD^11*, Todd A. Alonzo, PhD^12,13*, Soheil Meshinchi, MD, PhD¹⁴ and Jatinder K. Lamba, PhD^15,16

¹Pharmacotherapy and Translational Research, University of Florida, Gainesville, FL
²University of Florida, Gainesville
³Department of Health Promotion and Disease Prevention, University of Tennessee Health Science Center, Memphis, TN
⁴St. Jude Children's Research Hospital, Memphis, TN
⁵Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN
⁶St. Jude Children's Hospital, Memphis, TN
⁷Hematology/Oncology/BMT, Children's Mercy Kansas City, Kansas City, MO
⁸Leukemia & Lymphoma Society, Bronx, NY
⁹Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
¹⁰Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA
¹¹Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN
¹²Univ. of Southern California Keck School of Med., Monrovia, CA
¹³Children's Oncology Group, Monrovia, CA
¹⁴Translational Sciences and Therapeutics, Fred Hutchinson Cancer Research Center, Seattle, WA
¹⁵Umn Center For Allied Health Programs, Gainesville, FL
¹⁶UF Health Cancer Center, University of Florida, Gainesville, FL

Yotaro Ochi, MD, PhD^1*, Yasuhito Nannya, MD, PhD^1,2, Markus Liew-Littorin^3*, Senji Kasahara, MD, PhD^4*, Nobuhiro Hiramoto, MD^5*, Nobuhiro Kanemura, MD, PhD⁶, Nobuo Sezaki^7*, Maki Sakurada^8*, Makoto Iwasaki, MD, PhD^9*, Junya Kanda, MD, PhD^10*, Yasunori Ueda, MD, PhD¹¹, Satoshi Yoshihara, MD, PhD¹², Albin Osterroos, MD^13*, Masanori Motomura^1*, Masahiro Marshall Nakagawa, MD, PhD¹, Ryunosuke Saiki^1*, Akinori Yoda, PhD^1*, Rurika Okuda, MSc, BS^1*, Yuichi Shiraishi^14*, Takayuki Ishikawa, MD¹⁵, Satoru Miyano^14,16*, Akifumi Takaori-Kondo, MD, PhD⁸, Soren Lehmann, MD, PhD^13,17* and Seishi Ogawa^18,19,20

¹Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
²Division of Hematopoietic Disease Control, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
³Division of Hematology, Department of Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
⁴Department of Hematology, Gifu Municipal Hospital, Gifu, Japan
⁵Department of Hematology, Kobe City Medical Center General Hospital, Kobe, Japan
⁶Department of Hematology and Infectious Disease, Gifu University Hospital, Gifu, Japan
⁷Department of Hematology, Chugoku Central Hospital, Hiroshima, Japan
⁸Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⁹Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Nara, NAR, Japan
¹⁰Department of Hematology / Oncology, Kyoto University Graduate School of Medicine, Kyoto, Japan
¹¹Department of Hematology/Oncology, Transfusion and Hemapheresis Center, Kurashiki Central Hospital, Kurashiki, Japan
¹²Department of Respiratory Medicine and Hematology, Hyogo Medical University, Nishinomiya, Japan
¹³Department of Medical Sciences, Hematology, Uppsala University, Uppsala, Sweden
¹⁴Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
¹⁵Department of Hematology, Kobe City Medical Center General Hospital, Kobe, Hyogo, Japan
¹⁶Department of Integrated Analytics, M&D Data Science Center, Tokyo Medical and Dental University, Tokyo, Japan
¹⁷Center for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institute, Stockholm, Sweden
¹⁸Center for Hematology and Regenerative Medicine, Department of Medicine (MedH), Karolinska Institutet, Huddinge, Sweden
¹⁹Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan
²⁰Department of Pathology and Tumor Biology, Kyoto University Graduate School of Medicine, Sakyoku, KYO, Japan

Andrew Stiff, MD, PhD¹, Deedra Nicolet², Maarten Fornerod, PhD^3*, Ben Kelly^4*, Katherine Miller^5*, Krzysztof Mrózek, MD, PhD⁶, Isaiah Boateng^7*, Bailee Nicole Kain, PhD^8*, Elizabeth Garfinkle, BS^9*, Eileen Y Hu, BS^10*, Saranga Wijeratne^5,9*, Gregory Wheeler^9*, Christopher J. Walker, PhD^2*, Jill Buss, BS⁶, Adrienne Heyrosa^7*, Helee Desai^7*, Andrea Laganson, MS^11*, Yazan Abu-Shihab, MD^12*, Hasan Abaza^7*, Alice Mims, MD¹³, Christopher C. Oakes, PhD¹⁴, Bethany L Mundy-Bosse, PhD¹⁵, Andrew J Carroll, PhD¹⁶, Bayard L Powell, MD¹⁷, Jonathan E Kolitz, MD¹⁸, Richard Stone¹⁹, Electra D Paskett, PhD^20*, Ross L Levine, MD²¹, Kamal Menghrajani, MD²², Debyani Chakravarty, PhD^23*, Michael F. Berger, PhD^23*, Nathan Salomonis, PhD^24*, Daniel Bottomly^25*, Shannon K McWeeney, PhD^25*, Jeffrey W Tyner, PhD²⁶, John C. Byrd, MD²⁷, H. Leighton Grimes, PhD⁸, Elaine R Mardis, PhD^7,28,29* and Ann-Kathrin Eisfeld, MD*^2,29

¹Depatment of Internal Medicine, Division of Hematology, Ohio State University, Columbus, OH
²Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University, Columbus, OH
³Erasmusmc Sophia, Rotterdam, ZH, NLD
⁴Nationwide Children's Hospital and Ohio State University College of Medine, Columbus, OH
⁵The Steve and Cindy Rasmussen Institute For Genomic Medicine, Abigail Wexner Res, Columbus, OH
⁶Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University Comprehensive Cancer Center, Columbus, OH
⁷The Ohio State University Comprehensive Cancer Center, Columbus, OH
⁸Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁹The Steve and Cindy Rasmussen Institute For Genomic Medicine, Nationwide Children's Hospital, Columbus, OH
¹⁰University of Texas Southwestern, Dallas, TX
¹¹Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University Comprehensive Cancer Center, Columbus
¹²The Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University Comprehensive Cancer Center, Columbus, OH
¹³Division of Hematology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH
¹⁴Division of Hematology, Department of Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, OH
¹⁵Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH
¹⁶Department of Genetics, University of Alabama at Birmingham, Birmingham, AL
¹⁷Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, NC
¹⁸Northwell Cancer Center, Hofstra/Northwell School of Medicine, Lake Success, NY
¹⁹Dana-Farber Cancer Institute, Boston, MA
²⁰Department of Internal Medicine, Division of Cancer Prevention and Control, The Ohio State University Comprehensive Cancer Center, Columbus, OH
²¹Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
²²MSKCC Memorial Sloan Kettering Cancer Center, New York, NY
²³Memorial Sloan-Kettering Cancer Center, New York, NY
²⁴Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
²⁵Knight Cancer Institute, Oregon Health & Science University, Portland, OR
²⁶Knight Cancer Institute, Oregon Health and Science University, Portland, OR
²⁷Department of Internal Medicine, University of Cincinnati, Cincinnati, OH
²⁸Nationwide Children's Hospital, Columbus, OH
²⁹Contributed equally, #

Juan Barajas, PhD¹, Masayuki Umeda, MD, PhD², Jing Ma, PhD^2*, Mahsa Khanlari, MD¹, Michael P Walsh, PhD^1*, Tamara Westover, BS², Lisett Contreras, PhD^1*, Guangchun Song^2*, Xiaotu Ma, PhD¹, Melvin Thomas III, PhD¹ and Jeffery M. Klco, MD, PhD¹

¹St. Jude Children's Research Hospital, Memphis, TN
²Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN

Diego Pereira-Martins, PhD^1*, César Alexander Ortiz Rojas, Ph.D.^2*, Isabel Weinhaeuser, PhD^1*, Bart-Jan Wierenga, PhD^1*, Vincent Van Den Boom, Ph.D.^1*, Fatemeh Mojallali, MSc^1*, Dominique Sternadt, MSc^1*, Thiago Mantello Bianco, Ph.D.^3*, Nisha van der Meer, MD, MSc^1*, Douglas RA Silveira, MD, PhD^4*, Lynn Quek, MD, PhD^5*, Emanuele Ammatuna, MD, PhD^1*, Antonio R Lucena-Araujo, Prof.^6*, Gerwin A. Huls, Prof.⁷, Eduardo Magalhães Rego, MD, PhD^8,9 and Jan Jacob Schuringa, PhD¹⁰

¹Department of Experimental Hematology, University Medical Centre Groningen, Groningen, Netherlands
²Department of Internal Medicine, Medical School of Ribeirao Preto and the Center for Cell Based Therapy, University of São Paulo, Sao Paulo, Brazil
³Department of Medical Images, Haematology, and Clinical Oncology, Ribeirão Preto Medical School, University of Sao Paulo, Ribeirão Preto, Brazil
⁴School of Cancer and Pharmaceutical Sciences, King's College London, London, ENG, United Kingdom
⁵Myeloid Leukaemia Genomics and Biology Group, School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
⁶Department of Genetics, Federal University of Pernambuco, Recife, Brazil
⁷Department of Hematology, University Medical Center Groningen, Groningen, Netherlands
⁸Hematology Service, LIM-31 and State of Sao Paulo Cancer Institute, University of São Paulo, Faculdade de Medicina, São Paulo, São Paulo, Brazil
⁹Instituto do Cancer do Estado de Sao Paulo, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, BRA
¹⁰Department of Experimental Hematology, University Medical Center - Groningen, Groningen, Netherlands

Martina Pigazzi, PhD^1,2*, Claudia Tregnago, PhD^1*, Rhonda E Ries, MA^3*, Maddalena Benetton, PhD^1*, Todd A. Alonzo, PhD^4*, Nicolas Duployez, PharmD, PhD^5*, Edwin Sonneveld, PhD^6*, Jonas Abrahamsson^7*, Linda Fogelstrand, MD, PhD⁸, Nils Von Neuhoff, PhD^9*, Henrik Hasle¹⁰, Dirk Reinhardt, MD¹¹, Franco Locatelli, MD, PhD¹² and Soheil Meshinchi, MD, PhD¹³

¹Department of Women's and Children's Health, Onco-hematology lab and clinic, University of Padova, Padova, Italy
²Foundation Istituto Ricerca Pediatrica (IRP), Padova, Italy
³Translational Sciences and Therapeutics, Fred Hutchinson Cancer Center, Seattle, WA
⁴Children's Oncology Group, Monrovia, CA
⁵Hôpital Claude Huriez, Lille, France
⁶Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
⁷Institute of Clinical Sciences, Department of Pediatrics, Queen Silvias Childrens Hospital, Gothenburg, Sweden
⁸Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
⁹Department of Pediatric Hematology and Oncology, University Hospital Essen, Germany, Essen, Germany
¹⁰Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
¹¹Department of Pediatrics III, University Children’s Hospital Essen, University of Duisburg-Essen, Essen, Germany
¹²Department of Pediatric Hematology and Oncology, IRCCS Ospedale Pediatrico Bambino Gesù, Catholic University of the Sacred Heart, Rome, Bambino Gesù Children's Hospital, Catholic University of the Sacred Heart, Roma, Italy
¹³Translational Sciences and Therapeutics, Fred Hutchinson Cancer Research Center, Seattle, WA