Ilaria Iacobucci, PhD¹, Andy G.X. Zeng², Qingsong Gao, PhD^1*, Laura Garcia Prat, PhD, BSc, MSc^3*, Pradyumna Baviskar^1*, Sayyam Shah^2*, Alexander Murison, PhD^4*, Veronique Voisin^5*, Colin Bailey^6*, Matthew Lear^6*, Anjali S. Advani, MD⁷, Selina M Luger, MD, FRCPC⁸, Elisabeth Paietta, PhD^9*, Wendy Stock, MD¹⁰, John E. Dick, PhD^2,11 and Charles G. Mullighan, MBBS, MD¹

¹Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
²Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
³Dept of Molecular Genetics, University of Toronto, Toronto, ON, CAN
⁴Princess Margaret Cancer Centre, Toronto, ON, CAN
⁵Princess Margaret Cancer Centre, Toronto, Canada
⁶Department of Pathology, St. Jude Children’s Research Hospital, Memphis, TN
⁷Leukemia Program, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
⁸Perelman School of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA
⁹Montefiore Medical Ctr. North Div, Bronx, NY
¹⁰University of Chicago, Chicago, IL
¹¹Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada

Hanna Thorsson, PhD^1*, Rasmus Henningsson, PhD^2*, Noelia Puente-Moncada, PhD^2*, Ludvig Sjöström^2*, Helena Ågerstam^1*, Pablo Enrique Peña-Martínez^1*, Carl Sandén, PhD^2*, Marianne Rissler^1*, Anders Castor^3*, Hanne Vibeke Marquart, MD, PhD^4*, Signe Modvig, MD, PhD^4*, Kajsa Paulsson⁵, Cornelis Pronk, MD, PhD^3*, Kjeld Schmiegelow⁴, Axel Hyrenius Wittsten, PhD^6*, Christina Orsmark-Pietras, PhD^1*, Henrik PhD Lilljebjörn^1* and Thoas Fioretos, MD, PhD¹

¹Division of Clinical Genetics, Lund University, Lund, Sweden
²Division of Clinical Genetics, Lund University, Lund, SWE
³Childhood Cancer Center, Skåne University Hospital, Lund, Sweden
⁴Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark
⁵Department of Clinical Genetics, Lund University, Lund, Sweden
⁶Department of Laboratory Medicine, Division of Clinical Genetics, Lund University, Lund, Sweden

Lorenz Bastian^1,2*, Thomas Beder^1*, Malwine Barz, PhD^2,3*, Sonja Bendig^2,4*, Lorenz Bartsch^3*, Wencke Walter, PhD^5*, Nadine Wolgast^2*, Björn Brändl^6,7*, Christian Rohrandt^8*, Björn-Thore Hansen^1*, Alina M. Hartmann^2,3*, Katharina Iben^2,3*, Miriam Bultmann^3*, Johannes Zimmermann^9*, Michael Wittig^10*, Guranda Chitadze^2*, Martin Neumann^2*, Folker Schneller, MD^11*, Walter Fiedler, MD¹², Björn Steffen, MD^13*, Matthias Stelljes, MD¹⁴, Christoph Faul, MD¹⁵, Stefan Schwartz, MD^16*, Franz-Josef Müller^17,18*, Gunnar Cario, MD^2,19*, Lana Harder^20*, Claudia Haferlach, MD⁵, Heike Pfeifer^21*, Nicola Goekbuget, MD²², Monika Brüggemann^1,2* and Claudia D Baldus, MD^1,2*

¹Medical Department II, University Cancer Center Schleswig-Holstein, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany
²Clinical Research Unit CATCH ALL (KFO 5010/1) funded by the Deutsche Forschungsgemeinschaft, Kiel, Germany
³Medical Department II, University Cancer Center Schleswig-Holstein, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, DEU
⁴University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, DEU
⁵MLL Munich Leukemia Laboratory, Munich, Germany
⁶Department of Psychiatry and Psychotherapy, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany
⁷Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, DEU
⁸Department of Psychiatry and Psychotherapy, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, DEU
⁹Department of Evolutionary Ecology and Genetics, Zoological Institute, Christian-Albrechts-University Kiel, Kiel, Germany
¹⁰Institute for Clinical Molecular Biology, Kiel University, Kiel, Germany
¹¹Klinikum Rechts der Isar der TU München, Munich, Germany
¹²University Hospital Hamburg-Eppendorf, Hamburg, DEU
¹³Department of Hematology and Oncology, Unversity Hospital Frankfurt, Frankfurt, Frankfurt am Main, Germany
¹⁴Department of Medicine A/Hematology and Oncology, University of Muenster, Münster, Germany
¹⁵Department of Internal Medicine II, Hematology, Oncology, Clinical Immunology and Rheumatology, University Hospital Tuebingen, Tuebingen, Germany
¹⁶Department of Hematology, Oncology and Tumor Immunology (Campus Benjamin Franklin), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Berlin, Germany
¹⁷University Hospital Schleswig Holstein, Department of Psychiatry and Psychotherapy, Kiel, Germany
¹⁸Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany
¹⁹Department of Pediatrics, University Hospital Schleswig-Holstein, Kiel, Germany
²⁰Institut für Tumorgenetik Nord, Kiel, Germany
²¹Department of Medicine II, Hematology/Oncology, Goethe University Hospital, Frankfurt/M., Frankfurt/M., Germany
²²Department of Medicine II, Hematology/Oncology, Goethe University Hospital, Frankfurt, Germany

Mathieu Simonin^1,2*, Loïc Vasseur^3*, Etienne Lengline^4*, Ludovic Lhermitte^5*, Aurelie Cabannes-Hamy, MD^6*, Marie Balsat, MD^7*, Aline Schmidt^8*, Marie Emilie Dourthe, MD, PhD^1,9*, Aurore Touzart, MD, PhD^10*, Carlos Graux^11*, Nathalie Grardel^12*, Jean-Michel Cayuela, PharmD, PhD^13*, Isabelle Arnoux, PharmD^14*, Virginie Gandemer^15*, Françoise Huguet, M.D.^16*, Stephane Ducassou, MD, PhD^17*, Véronique Lhéritier^18*, Yves Chalandon, MD¹⁹, Norbert Ifrah, MD, PhD²⁰, Herve Dombret, MD²¹, Elizabeth A. Macintyre, MD, PhD²², Arnaud Petit, MD, PhD^23*, Philippe Rousselot^24*, Jerome Lambert, MD, PhD^25*, André Baruchel^26*, Nicolas Boissel, MD, PhD^21,27* and Vahid Asnafi, MD, PhD^1,28*

¹Laboratory of Onco-Hematology, Necker Enfants-Malades Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris Cité, Paris, France, Paris, France
²Sorbonne Université / Trousseau Hospital / APHP, Paris, France
³Biostatistics and Medical Information Department, Saint Louis University Hospital, AP-HP, Université Paris Cité, Paris, France
⁴Department of Hematology, Saint Louis University Hospital, AP-HP, PARIS, FRA
⁵Laboratory of Onco-Hematology, Necker Enfants-Malades Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris Cité, Paris, France
⁶Department of Hematology, Versailles Hospital, Le Chesnay, France
⁷Clinical Hematology Department, Hospices Civils de Lyon, Lyon Sud Hospital, Pierre-Bénite, France, Lyon, France
⁸PRES LUNAM, Hematology Department, Angers University Hospital, Angers, France and INSERM U 892, Angers, France
⁹Department of Pediatric Hematology, Robert Debré Hospital, AP-HP, Université Paris Cité, Paris, France., Paris, France
¹⁰Laboratory of Onco-Hematology, Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France
¹¹Department of Hematology, Université catholique de Louvain, CHU UCL Namur - site Godinne, Yvoir, BEL
¹²Department of Hematology, University Hospital Claude Huriez, Lille, France
¹³Laboratory of Hematology and EA 3518 University Hospital Saint-Louis, AP-HP and Université de Paris, Paris, France
¹⁴Laboratory of Hematology, La Timone University Hospital, Assitance Publique des Hôpitaux de Marseille (AP-HM), Marseille, France
¹⁵Department of Pediatric Hematology and Oncology, University Hospital of Rennes, Rennes, France
¹⁶Centre Hospitalo-Universitaire de Toulouse, Institut Universitaire du Cancer de Toulouse-Oncopole, Service d’Hématologie, Toulouse, France
¹⁷Department of Pediatric Oncology and Hematology, Bordeaux University hospital, Bordeaux, France
¹⁸Service d’Hématologie Coordination GRAALL, HCL, Hôpital Lyon Sud, Pierre Bénite, France
¹⁹Univ. Hospital of Geneva, Geneva, Switzerland
²⁰PRES LUNAM, CHU Angers Service des Maladies du Sang and INSERM U 892, Angers, France
²¹Department of Hematology, Saint Louis University Hospital, AP-HP, Paris, France
²²Laboratory of Onco-Hematology, Necker Enfants-Malades Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris Cité, Paris, France, Paris, FRA
²³Department of Pediatric Hematology and Oncology, Assistance Publique-Hôpitaux de Paris (AP-HP), GH HUEP, Armand Trousseau Hospital, Paris, France
²⁴Department of Hematology, Versailles Hospital, Versaille, FRA
²⁵Biostatistics and Medical Information Department, Saint Louis University Hospital, AP-HP, Université Paris Cité, Paris, FRA
²⁶Department of Pediatric Hematology, Robert Debré Hospital, AP-HP, Université Paris Cité, Paris, France
²⁷Institut Universitaire d'Hématologie, EA-3518, University Hospital Saint-Louis, Assistance Publique des Hôpitaux de Paris (APHP), Paris, France
²⁸INSERM U1151, Institut Necker Enfants Malades (INEM), Paris, France

Shunsuke Kimura, MD, PhD¹, Petri Pölönen, PhD², Lindsey Montefiori, PhD², Kenneth Caldwell, MD³, Ilaria Iacobucci, PhD², Chelsey Chen^2*, Anthony Brown^4*, Katie Han^5*, Yen-Chun Liu^2*, Yunchao Chang, PhD^2*, Zhongshan Cheng^6*, Zhou Yinmei^7*, Chun Shik Park, PhD^2*, Sharnise Mitchell^8*, Noemi Reyes^4*, Allen Yeoh, MD^9*, Andishe Attarbaschi, Prof., MD^10*, Andrew Moore, MBBS, PhD, FRACP^11*, Atsushi Manabe, MD, PhD^12*, Barbara Buldini, MD, PhD^13,14, Kean Hui Chiew^15*, Chi Kong Li¹⁶, Ching-Hon Pui, MD⁵, Chunxu Qu^2*, Daisuke Tomizawa, MD, PhD¹⁷, Elisabeth Paietta, PhD^18*, Franco Locatelli, MD, PhD¹⁹, Gabriele Escherich, MD^20*, Gao Qingsong^2*, Hannah Elisa Muhle^20*, Hanne Vibeke Marquart^21,22*, Hester A. de Groot-Kruseman, PhD^23*, Jacob M. Rowe, MB, BS²⁴, Jan Stary, MD, DSc^25*, Jan Trka, MD, PhD²⁶, John Kim Choi, MD, PhD^27*, Jules P.P. Meijerink, PhD²³, Junko Takita, MD, PhD^28*, Katarzyna Pawinska-Wasikowska, MD, PhD^29*, Kjeld Schmiegelow, MD, DMsc^30*, Mariko Eguchi, MD³¹, Martin Schrappe, MD³², Martin Zimmermann, PhD^33*, Masatoshi Takagi, MD, PhD³⁴, Melissa Maybury^35*, Michael Svaton, MD^36*, Michaela Reiterova^36*, Michal Kicinski^37*, Motohiro Kato, MD, PhD^38*, Orietta Spinelli^39*, Pauline Mazilier, MD^40*, Paul G. Thomas, PhD^41*, Riccardo Masetti, MD, PhD^42*, Rishi Sury Kotecha, MB ChB, PhD^43,44*, Rob Pieters, MD, PhD, MSc²³, Sarah Elitzur, MD⁴⁵, Selina M Luger, MD, FRCPC⁴⁶, Shuhong Shen, MD, PhD⁴⁷, Sima Jeha, MD⁴⁸, Steven M. Kornblau, MD⁴⁹, Szymon Skoczen, Prof.^50*, Takako Miyamura⁵¹, Tiffaney Vincent^52*, Toshihiko Imamura, MD, PhD⁵³, Valentino Conter, MD^54*, Yanjing Tang^55*, Zhaohui Gu, PhD⁵⁶, Kathryn G. Roberts, PhD^2*, David T. Teachey, MD⁵⁷, Kristine R Crews, PharmD^4*, Cheng Cheng^7*, Jun J. J. Yang, PhD⁵⁸, Hiroto Inaba, MD, PhD⁵ and Charles G. Mullighan, MBBS, MD²

¹Department of Pathology, St. Jude Children's Research Hospital, Germantown, TN
²Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
³Gilead Sciences, Saint Petersburg, FL
⁴Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN
⁵Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN
⁶Center of Applied Bioinformatics, St Jude Children's Hospital, Memphis, TN
⁷Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN
⁸Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN
⁹Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
¹⁰Department of Pediatric Hematology and Oncology, St. Anna Children's Hospital, Medical University Vienna, Vienna, Austria
¹¹Child Health Research Centre, The University of Queensland, Brisbane, QLD, Australia
¹²Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, JPN
¹³Pediatric Onco-Hematology, Stem Cell Transplant and Gene Therapy Laboratory, Istituto di Ricerca Pediatrica (IRP)-Città della Speranza, Padova, Italy
¹⁴Pediatric Hematology, Oncology and Stem Cell Transplant Division, Maternal and Child Health Department, University of Padova, Padova, Italy
¹⁵National University of Singapore, Singapore, SGP
¹⁶Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong
¹⁷Division of Leukemia and Lymphoma, Children’s Cancer Center, National Center for Child Health and Development, Tokyo, Japan
¹⁸Department of Oncology, Montefiore Medical Center, Bronx, NY
¹⁹Department of Pediatric Hematology–Oncology and Cell and Gene Therapy, IRCCS Ospedale Pediatrico Bambino Gesù, Catholic University of the Sacred Heart, Rome, Italy
²⁰Clinic of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
²¹Department of Clinical Immunology, Rigshospitalet, Copenhagen, Denmark
²²Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
²³Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
²⁴Department of Hematology, Shaare Zedek Medical Center, Jerusalem, Israel
²⁵Department of Pediatric Hematology and Oncology, Second Faculty of Medicine, Charles University/University Hospital Motol, Prague, Czech Republic
²⁶CLIP - Childhood Leukaemia Investigation Prague, Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic
²⁷University of Alabama at Birmingham, BIRMINGHAM
²⁸Department of Pediatrics, Graduate School of Medicine Kyoto University, Kyoto, JPN
²⁹Department of Pediatric Oncology and Hematology, Jagiellonian University Medical College, Wielicka, Poland
³⁰Department of Pediatrics and Adolescent Medicine, Rigshospitalet University Hospital, Copenhagen, Denmark
³¹Department of Pediatrics, Ehime University, Toon, Ehime, JPN
³²Department of Pediatrics, University Hospital Schleswig-Holstein, Kiel, Germany
³³Department of Pediatric Hematology and Oncology, Medical School Hannover, Hannover, Germany
³⁴Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Tokyo, Japan
³⁵Child Health Research Centre, The University of Queensland, Brisbane, Australia
³⁶CLIP - Childhood Leukaemia Investigation Prague, Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, CZE
³⁷EORTC Headquarters, Brussels, BEL
³⁸Department of Pediatrics, Tokyo University, Tokyo, JPN
³⁹Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII Hospital, Bergamo, Italy
⁴⁰Pediatric hemato-oncology and transplantation, HUB - HUDERF, Brussels, Belgium
⁴¹Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN
⁴²Pediatric Hematology and Oncology, IRCCS Azienda Ospedaliero Universitaria di Bologna, University of Bologna, Bologna, Italy
⁴³Leukaemia Translational Research Laboratory, Telethon Kids Cancer Centre, Telethon Kids Institute, University of Western Australia, Perth, Australia
⁴⁴Department of Clinical Haematology, Oncology, Blood and Marrow Transplantation, Perth Children's Hospital, Perth, Australia
⁴⁵Department of Pediatric Hematology and Oncology, Schneider Children's Medical Center and Tel Aviv University, Petah Tikva, Israel
⁴⁶Perelman School of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA
⁴⁷Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
⁴⁸Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, TN
⁴⁹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵⁰Department of Pediatric Oncology and Hematology, Jagiellonian University Medical College, Krakow, POL
⁵¹Department of Pediatrics, Osaka University, Osaka, JPN
⁵²The Children's Hospital of Philadelphia, Philadelphia, PA
⁵³Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, JPN
⁵⁴Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy
⁵⁵Shanghai Children's Medical Center, Shanghai, China
⁵⁶City of Hope, Duarte, CA
⁵⁷Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA
⁵⁸Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, MEMPHIS, TN

Jingliao Zhang, MD¹, Yongjuan Duan^2*, Peng Wu^3*, Suyu Zong^4*, Wenyu Yang^1*, Li Zhang^5*, Tao Cheng⁶, Xiaofan Zhu, MD^7* and Yingchi Zhang^8*

¹Pediatric Blood Diseases Center, State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences, Tianjin, China
²State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical Co, Tianjin, CHN
³State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Tianjin, China
⁴State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin, China
⁵Anemia Therapeutic Center, Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, China
⁶State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Tianjin, China
⁷State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical Colleg, Tianjin, China
⁸State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences&Peking Union Medical College, Tianjin, China