65th ASH Annual Meeting & Exposition: 332. Thrombosis and Anticoagulation: Clinical and Epidemiological: Clonal Hematopoiesis of Indeterminate Potential (CHIP) and Cancer Associated Thrombosis (CAT): Understanding Risk as a Potential Means to Improve Patient Care

Symposia: Thrombosis and Anticoagulation: Clinical and Epidemiological Oral and Poster Abstracts
Oral

Research, Bleeding and Clotting, Anticoagulant Drugs, adult, Translational Research, epidemiology, Lymphomas, Non-Biological therapies, Clinical Research, health outcomes research, Genetic Disorders, thromboembolism, Diseases, real-world evidence, thrombotic disorders, Therapies, Lymphoid Malignancies, Study Population, Human

Room 28 A-D (San Diego Convention Center)

Moderators:

Jordan K Schaefer, MD, University of Michigan and Karlyn A. Martin, MD, MS, University of Vermont Larner College of Medicine

Disclosures:

Schaefer: Pfizer: Consultancy. Martin: Janssen Scientific Affairs: Research Funding; Penumbra: Consultancy.

4:30 PM

565

Development and External Validation of a Lymphoma-Specific Venous Thromboembolism Risk Assessment Model

Shengling Ma, MD¹, Kaitlin N Swinnerton²^*, Jennifer La, PhD²^*, Danielle Guffey³^*, Raka Bandyo⁴^*, Christopher I Amos⁵^*, Vipul Chitalia⁶^*, Giordana De Las Pozas⁷^*, Katy M Toale⁸^*, Xiangjun Xiao⁹^*, Cristhiam M. Rojas Hernandez, MD¹⁰, Katya Ravid, Dsc¹¹, Kelly Merriman¹²^*, Christopher R. Flowers, MD, MS¹³, Nathanael R Fillmore, PhD²^* and Ang Li, MD, MS¹⁴

¹Section of Hematology-Oncology, Baylor College of Medicine, HOUSTON, TX
²Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System, Boston, MA
³Institute for Clinical & Translational Research, Baylor College of Medicine, Houston, TX
⁴Harris Health System, Houston, TX
⁵Baylor College of Medicine, Houston, TX
⁶2Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System, Boston
⁷Department of Tumor Registry, The University of Texas MD Anderson Cancer Center, houston, TX
⁸Division of Pharmacy, The University of Texas MD Anderson Cancer Center, Houston, TX, Houston, TX
⁹baylor college of medicine, houston
¹⁰Benign Hematology, The University of Texas MD Anderson Cancer Center, Houston, TX
¹¹Boston Univ. School of Med., Boston, MA
¹²The University of Texas MD Anderson Cancer Center, Houston, TX
¹³Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX
¹⁴Section of Hematology-Oncology, Department of Medicine, Baylor College of Medicine, Houston, TX

4:45 PM

566

Dynamic Modelling for Cancer-Associated Venous Thromboembolism

Simon Mantha, MD, MPH¹, Rohan Singh¹^* and Jeffrey I. Zwicker, MD^1,2

¹Memorial Sloan Kettering Cancer Center, New York, NY
²Department of Medicine, Weill Cornell Medical College, New York, NY

5:00 PM

567

Discriminating Risk of Anticoagulant-Related Bleeding in Ambulatory Cancer Patients on Thromboprophylaxis

Kristen M. Sanfilippo, MD¹, Yan Yan, MD, PhD²^*, Marc Carrier, MD³ and Brian F. Gage, MD, MS⁴^*

¹St. Louis Veterans Affairs Medical Center Research Service, St. Louis, MO
²Washington University School of Medicine in St. Louis, St Louis, MO
³Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada
⁴Washington Univeristy School of Medicine in St. Louis, Saint Louis, MO

5:15 PM

568

Clonal Hematopoiesis and Venous Thromboembolism in the UK Biobank

Becky Zon, MD¹, Aswin Sekar, MD, PhD¹, Katharine Clapham, MD²^*, Abhishek Niroula, PhD^1,3^*, Alexander G. Bick, MD, PhD⁴^*, Christopher James Gibson, MD⁵, Gabriel K. Griffin, MD⁶^*, Md Mesbah Uddin, PhD, MS⁷^*, Pradeep Natarajan, MD MMSc^8,9,10^* and Benjamin L. Ebert, MD, PhD^11,12,13,14

¹Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA
²Department of Medicine, Division of Cardiology, University of Utah School of Medicine, Salt Lake City, UT
³Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden
⁴Department of Medicine, Vanderbilt University Medical Center, Nashville, TN
⁵Dana-Farber Cancer Institute, Boston, MA
⁶Department of Pathology, Dana-Farber Cancer Institute, Boston, MA
⁷Massachusetts General Hospital, Cambridge, MA
⁸Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA
⁹Harvard Medical School, Boston, MA
¹⁰Broad Institute, Boston, MA
¹¹Broad Institute of MIT and Harvard University, Cambridge, MA
¹²Howard Hughes Medical Institute, Boston, MA
¹³Department of Medicine, Harvard Medical School, Boston, MA
¹⁴Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA

5:30 PM

569

DNA Liquid Biopsies for Cancer-Associated Venous Thromboembolism Prediction

Justin Jee¹^*, Angela Rose Brannon¹^*, Chris Fong¹^*, Adrian Lee²^*, Lauren Gray²^*, Karl Pichotta¹^*, Anisha Luthra¹^*, Monica Diosdado¹^*, Mohammad Haque¹^*, Jiannan Guo³^*, Jennifer Hernandez³^*, Kavita Garg³^*, Andriy Derkach, PhD⁴^*, Clare Wilhelm¹^*, Rohan Singh¹^*, Maria E. Arcila, M.D.¹^*, Nick Pavlakis²^*, Stephen Clarke²^*, Sohrab P Shah¹^*, Pedram Razavi¹^*, Jorge Reis-Filho¹^*, Marc Ladanyi¹^*, Nikolaus Schultz¹^*, Jeffrey I. Zwicker, MD⁵, Michael F. Berger, PhD⁶^*, Bob T Li¹^* and Simon Mantha, MD, MPH¹

¹Memorial Sloan Kettering Cancer Center, New York, NY
²GenesisCare, Sydney, Australia
³Resolution Bioscience, Agilent Technologies, Kirkland, WA
⁴Department of Biostatistics and Epidemiology, Memorial Sloan Kettering Cancer Center, New York, NY
⁵Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA
⁶Memorial Sloan-Kettering Cancer Center, New York, NY

5:45 PM

570

Bleeding and Thrombotic Outcomes in Adults with Cancer-Associated Splanchnic Vein Thrombosis and Thrombocytopenia

Michael Andersen Jr., MD¹, Maria J. Fernandez Turizo, MD², Laura Dodge, ScD³^*, Charles Hsu, MD⁴^*, Kevin Barnum, MD, PhD⁵^*, Jeffrey I. Zwicker, MD⁶ and Rushad Patell, MBBS⁵

¹Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
²Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Brookline, MA
³Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA
⁴Memorial Sloan Kettering Cancer Center, New York, NY
⁵Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
⁶Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA

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^*signifies non-member of ASH

332.O1.6 332. Thrombosis and Anticoagulation: Clinical and Epidemiological: Clonal Hematopoiesis of Indeterminate Potential (CHIP) and Cancer Associated Thrombosis (CAT): Understanding Risk as a Potential Means to Improve Patient Care