65th ASH Annual Meeting & Exposition: 113. Sickle Cell Disease, Sickle Cell Trait and Other Hemoglobinopathies, Excluding Thalassemias: Basic and Translational: Pathophysiology of Sickle Hemoglobinopathies: From Mice to Humans

Symposia: Sickle Cell Disease, Sickle Cell Trait and Other Hemoglobinopathies, Excluding Thalassemias: Basic and Translational Oral and Poster Abstracts
Oral

Research, Translational Research, Biological Processes, pathogenesis

Room 33 (San Diego Convention Center)

Moderators:

Jonathan M. Flanagan, PhD, Baylor College of Medicine and Ran An, PhD, Case Western Reserve University

Disclosures:

No relevant conflicts of interest to declare.

4:30 PM

559

Mechanisms of Inflammatory Caspase Activation in Sickle Cell Disease

Suruchi Salgar, BS¹^*, Beatriz Bolivar, PhD²^* and Lisa Bouchier-Hayes, PhD¹

¹Baylor College of Medicine, Houston, TX
²Baylor College of Medicine, Houston

4:45 PM

560

Cerebral Hemodynamics in Infants with Sickle Cell Disease Indicate Presence of Early Hemodynamic Stress

Pei-Yi Lin, PhD^1,2,3^*, Rutvi Vyas, MS^2,3^*, Michael Woglom, BS^2,3^*, Jeffrey N. Stout, PhD^1,2,3^*, Erica B. Esrick, MD^1,4, Matthew M. Heeney, MD^1,4, Natasha Archer, MD^1,4, P. Ellen Grant, MD, MS^1,2,3,5,6^* and Jason Sutin, PhD^1,2,3^*

¹Department of Pediatrics, Harvard Medical School, Boston, MA
²Fetal-Neonatal Neuroimaging and Developmental Science Center, Boston Children’s Hospital, Boston, MA
³Department of Pediatrics, Division of Newborn Medicine, Boston Children’s Hospital, Boston, MA
⁴Dana–Farber/Boston Children’s Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA
⁵Department of Radiology, Boston Children’s Hospital, Boston, MA
⁶Department of Radiology, Harvard Medical School, Boston, MA

5:00 PM

561

Pyruvate Kinase Thermostability Is Associated with Red Blood Cell Adhesion, Deformability and Oxygen Affinity in Patients with Sickle Cell Disease

Marissa J.M. Traets¹^*, Sigrid van der Veen²^*, Jennifer Bos¹^*, Laura van Pelt¹^*, Aida Kidane, MD³^*, Brigitte A. van Oirschot¹^*, Wouter W. van Solinge¹^*, Saskia Schols⁴^*, Mandy N. Lauw⁵, Marjon H. Cnossen³^*, Erfan Nur, MD, PhD^6,7, Bart J. Biemond⁸, Eduard J. Van Beers²^*, Anita W. Rijneveld, M.D.⁵, Richard van Wijk¹ and Minke A.E. Rab^1,5^*

¹Central Diagnostic Laboratory - Research, University Medical Center Utrecht, Utrecht, Netherlands
²Center for Benign Hematology, Thrombosis and Hemostasis - Van Creveldkliniek, University Medical Center Utrecht, Utrecht, Netherlands
³Department of Pediatric Hematology, Erasmus MC Sophia Children's Hospital, Rotterdam, Netherlands
⁴Department of Hematology, Radboud university medical center, Nijmegen, Netherlands
⁵Department of Hematology, Erasmus University Medical Center, Rotterdam, Netherlands
⁶Department of Hematology, Amsterdam University Medical Centers, Amsterdam, Netherlands
⁷Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory, Amsterdam, Netherlands
⁸Department of Hematology, Amsterdam University Medical Centers, location University of Amsterdam, Amsterdam, Netherlands

5:15 PM

562

Pharmacologic Reduction of Platelet Count Attenuates Whole Blood Hypofibrinolysis in a Mouse Model of Sickle Cell Disease

Anton Ilich, MD¹^*, Karnsasin Seanoon²^*, Fatima Trebak²^*, Andras Gruber, MD³, Nigel S. Key, MD⁴ and Rafal Pawlinski, PhD⁵

¹UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
²UNC Blood Research Center, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC
³Aronora, Inc., Portland, OR
⁴UNC Blood Reserach Center, Department of Medicine, University of North Carolina, Chapel Hill, NC
⁵UNC Blood Research Center, University of North Carolina, Chapel Hill, NC

5:30 PM

563

Characterizing Pregnancy Outcomes in a Humanized Mouse Model of Sickle Cell Disease

Christopher Chambliss, PhD¹, Elizabeth Manci, MD²^*, Earl Fields³^*, Jesse Bueno¹^*, Adeola Michael, PhD⁴^*, Satheesh Chonat, MD¹ and David R Archer, PhD⁵

¹Aflac Cancer and Blood Disorders Center, Emory University, Atlanta, GA
²University of South Alabama, Mobile, AL
³Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Emory University Department of Pediatrics, Atlanta, GA
⁴Aflac Cancer and Blood Disorders Center, Emory University, Atlanta
⁵Aflac Cancer & Blood Disorders Center, Emory University, Atlanta, GA

5:45 PM

564

Validation of Townes As Mice As a Model of Chronic Kidney Disease and Venous Thrombosis Associated with Sickle Cell Trait

Malgorzata Kasztan, PhD¹, Steven P Grover, PhD², Fatima Trebak³^*, Mohammad O Sako¹, Nigel S. Key, MD² and Rafal Pawlinski, PhD⁴

¹Department of Pediatrics, Division of Hematology-Oncology, University of Alabama at Birmingham, Birmingham, AL
²UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
³UNC Blood Research Center, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC
⁴UNC Blood Research Center, University of North Carolina, Chapel Hill, NC

See more of: Oral and Poster Abstracts

<< Previous Session | Next Session >>

^*signifies non-member of ASH

113.O2.6 113. Sickle Cell Disease, Sickle Cell Trait and Other Hemoglobinopathies, Excluding Thalassemias: Basic and Translational: Pathophysiology of Sickle Hemoglobinopathies: From Mice to Humans