Jayakumar Vadakekolathu, PhD^1*, Tung On Yau^1*, Sarah E. Church, PhD^2*, Michael P. Rettig, PhD³, Ibrahim Aldoss, M.D.⁴, Geoffrey L Uy, MD⁵, Norbert Vey, MD⁶, Ashkan Emadi, M.D., Ph.D.⁷, Peter H. Sayre, MD, PhD⁸, Roland B. Walter, MD, PhD, MS⁹, Matthew C Foster, MD¹⁰, Martha L. Arellano, MD¹¹, John E. Godwin, MD¹², Matthew J. Wieduwilt, MD, PhD¹³, Michael T. Byrne, DO¹⁴, Laura C. Michaelis, MD¹⁵, Patrick J. Stiff, MD¹⁶, Matteo Giovanni Carrabba, MD^17*, Patrice Chevalier, MD, PhD^18*, Emmanuel Gyan, MD, PhD¹⁹, Christian Recher, MD, PhD²⁰, Anjali S Advani, MD²¹, Martin Wermke^22*, Harry P. Erba²³, Fabio Ciceri, MD^24*, Geert Huls, MD, PhD²⁵, Mojca Jongen-Lavrencic, MD, PhD²⁶, Farhad Ravandi, MBBS²⁷, Antonio Curti, MD PhD²⁸, Max S. Topp, MD²⁹, John Muth, MS^30*, Patrick Kaminker, PhD^30*, Bob Lowenberg, MD, PhD³¹, Ivana Gojo, MD³², Leo Luznik, MD³², John F. DiPersio, MD⁵, Jan K Davidson-Moncada, MD, PhD³⁰ and Sergio Rutella, MD, PhD, FRCPath^1,33

¹John van Geest Cancer Research Centre, Nottingham Trent University, Nottingham, United Kingdom
²NanoString Technologies, Inc., Everett, WA
³Department of Internal Medicine, Division of Oncology, Washington Univ. School of Med., Saint Louis, MO
⁴University of Southern California, Duarte, CA
⁵BMT and Leukemia Program, Department of Medicine, Washington University School of Medicine, Saint Louis, MO
⁶Hematologie clinique, Institut Paoli Clamettes, Marseille, France
⁷University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD
⁸University of California, San Francisco, San Francisco, CA
⁹Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
¹⁰Lineberger Comprehensive Cancer Center, UNC, Chapel Hill, Chapel Hill, NC
¹¹Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA
¹²Providence Portland Medical Center, Portland, OR
¹³Moores Cancer Center, University of California, San Diego, La Jolla, CA
¹⁴Department of Medicine, Division of Hematology-Oncology, Vanderbilt University Medical Center, Nashville, TN
¹⁵Division of Hematology/Oncology, Department of Medicine, The Medical College of Wisconsin Inc., Milwaukee, WI
¹⁶Loyola University Chicago Stritch School of Medicine, Maywood, IL
¹⁷Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy
¹⁸Department of Hematology and Cell Therapy, CHU Nantes, Nantes, France
¹⁹CHU de Tours - Hôpital Bretonneau, Tours, France
²⁰Service d'Hématologie, Centre Hospitalier Universitaire de Toulouse, Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France
²¹Cleveland Clinic, Taussig Cancer Institute, Cleveland, OH
²²NCT/UCC Early Clinical Trial Unit, University Hospital Carl Gustav Carus, Dresden, Germany
²³Duke University School of Medicine, Durham, NC
²⁴Haematology and BMT Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy
²⁵Department of Hematology, University Medical Center Groningen, Groningen, GZ, Netherlands
²⁶Erasmus University Medical Center, Rotterdam, Netherlands
²⁷Department of Leukemia, University of Texas- MD Anderson Cancer Center, Houston, TX
²⁸Hematology/Oncology "L. e A. Seràgnoli", Sant’Orsola-Malpighi University Hospital, Bologna, Bologna, Italy
²⁹Medizinische Klinik Und Poliklinik II, Universitätsklinikum Würzburg, Würzburg, Germany
³⁰MacroGenics, Inc., Rockville, MD
³¹Department of Hematology, Erasmus University Medical Center, Rotterdam, Netherlands
³²Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD
³³Centre for Health, Ageing and Understanding Disease (CHAUD), Nottingham Trent University, Nottingham, United Kingdom

Hassan Awada, MD¹, Arda Durmaz^2*, Carmelo Gurnari, MD^3*, Misam Zawit, MBBS^1*, Sunisa Kongkiatkamon, MD^1*, Simona Pagliuca, MD¹, Cassandra M. Kerr, MS^4*, Hetty E. Carraway, MD, MBA⁵, Aziz Nazha, MD⁶, Mikkael A. Sekeres, MD, MS⁷, Jaroslaw P. Maciejewski, MD, PhD⁴ and Valeria Visconte, PhD¹

¹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
²Department of Systems biology and Bioinformatics, CWRU, cleveland
³Department of Translational Hematology and Oncology, Taussig Cancer Institute, Cleveland, OH
⁴Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
⁵Department of Hematology and Medical Oncology, Leukemia Program, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
⁶Leukemia Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
⁷Leukemia Program, Department of Hematology and Medical Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH

Lisa Wei, BS¹, Diane Trinh^1*, Rhonda E. Ries, MA^2*, Dan Jin, PhD^1*, Richard D. Corbett^3*, Jenny L. Smith, MSc, MEd^2*, Scott N. Furlan, MD^4*, Soheil Meshinchi, MD, PhD⁵ and Marco A. Marra, PhD^1,6

¹Canada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, BC, Canada
²Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
³Canada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, Canada
⁴Fred Hutchinson Cancer Research Center, Seattle, WA
⁵Clinical Research Division, Fred Hutchinson Cancer Rsrch. Ctr., Seattle, WA
⁶Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada

Richard Addo, MD, PhD^1*, Kathrin Davari, PhD^1*, Silke Raffegerst, PhD^1*, Stefanie Tippmer^1*, Dolores J. Schendel, PhD^1*, Kai Pinkernell, MD, MBA¹ and Simone Thomas, MD^2,3*

¹Medigene Immunotherapies GmbH, Martinsried, Germany
²Regensburg Center for Interventional Immunology, Regensburg, Germany
³Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany

Zhigang Cai^1*, Reuben Kapur, PhD², Xiaoyu Lu^3*, Chi Zhang, PhD^4*, Sai Nelanuthala^5*, Jonathan Kotzin^6*, Adam Williams^7*, Jorge Henao-Mejia^6*, Fabiola Aguilera^1*, Abigail Hadley^8*, Fang Fang^9* and Kenneth Nephew^9*

¹3Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, Indianapolis, IN
²Herman B Wells Center for Pediatric Research, Indiana Univ. School of Med., Indianapolis, IN
³3Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, Indianapolis
⁴Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN
⁵Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN
⁶Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
⁷Department of Genetics and Genomic Sciences, University of Connecticut Health Center, Farmington, CT
⁸1Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, USA., Indianapolis, IN
⁹Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana, USA., Indianapolis

Claudia Nunez-Torron, MD^1*, Juan Marquet Palomanes^2*, Valentín Garcia-Gutiérrez, MD, PhD³, Adolfo Saez^2*, Alejandro Luna, MD^3*, Jesus Villarrubia, PhD^3*, Gemma Moreno Jiménez, MD^4*, Javier Lopez Jimenez, MD, PhD^5* and Pilar Herrera Puente^6*

¹Hematology, Hospital Ramon y Cajal, 28034, Spain
²Hospital Universitario Ramón y Cajal, Madrid, Spain
³Hematology, Hospital Universitario Ramón y Cajal, Madrid, Spain
⁴Hematology and Hemotherapy Department, Hospital Universitario Ramón y Cajal, Madrid, Spain
⁵University Hospital Ramon y Cajal, Madrid, Spain
⁶Hematology and Hemotherapy, Hospital Universitario Ramón y Cajal, Madrid, Spain

Jacob Shreve, BS, MD, MS¹, Manja Meggendorfer, PhD², Sudipto Mukherjee, MD, PhD, MPH³, Wencke Walter, PhD^4*, Stephan Hutter, PhD^4*, Ahed Makhoul, MD^5*, Nathan Radakovich, BA⁶, Hassan Awada, MD⁷, Yihong Guan, PhD^7*, Teodora Kuzmanovic, BA^8*, Jaroslaw P. Maciejewski, MD, PhD⁸, Claudia Haferlach, MD⁹, Mikkael A. Sekeres, MD, MS¹⁰, Torsten Haferlach, MD¹¹ and Aziz Nazha, MD¹²

¹Cleveland Clinic, Granger, IN
²MLL Munich Leukemia Laboratory, Munich, Bavaria, Germany
³Leukemia Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
⁴MLL Munich Leukemia Laboratory, Munich, Germany
⁵Taussig Cancer Institute, Cleveland Clinic, Leukemia Program, Department of Hematology and Medical Oncology, Cleveland, OH
⁶Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Bellingham, WA
⁷Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
⁸Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
⁹MLL Munich Leukemia Laboratory, Inning am Ammersee, Germany
¹⁰Leukemia Program, Department of Hematology and Medical Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH
¹¹MLL Munchner Leukamie Labor Gmbh, Munchen, Germany
¹²Leukemia Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Quantitative Health Sciences, Avon Lake, OH

Ali Khateb, PhD^1,2*, Anagha Deshpande, PhD^1*, Yongmei Feng, PhD^1*, Ikrame Lazar, PhD^1,2*, Joo Sang Lee, PhD^3*, Bertrand Fabre, PhD^1,2*, Yan Li, PhD^1*, Darren Finlay^4*, Yu Fujita, PhD^1,5*, Tongwu Zhang, PhD^6*, Ian Pass, PhD^1*, Ido Livneh, PhD^2*, Carol Burian^7*, James R. Mason, MD^7*, Ronit Almog, MD^8*, Nurit Horesh, MD^9*, Yishai Ofran, MD^2,9, Kevin Brown^6*, Kristiina Vuori, PhD^1*, Michael Jackson, PhD^1*, Eytan Ruppin, PhD^3*, Aniruddha J. Deshpande, PhD¹ and Ze'ev A. Ronai, PhD^1,2*

¹Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA
²Technion Integrated Cancer Center, Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
³Cancer Data Science Lab, National Cancer Institute, National Institute of Health, Bethesda, MD
⁴Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA
⁵Division of Respiratory Medicine, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
⁶Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD
⁷Scripps MD Anderson Cancer Center, La Jolla, CA
⁸Rambam Health Care Campus, Epidemiology Department and Biobank, Haifa, Israel
⁹Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, Haifa, Israel

Vinitha Mary Kuruvilla, MSc^1*, Qi Zhang, PhD^1*, Naval Daver, MD¹, Krystal Watkins^2*, Callum M Sloss, PhD³, Patrick A Zweidler-McKay, MD, PhD², Angela Romanelli, PhD² and Marina Konopleva, MD, PhD⁴

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²ImmunoGen, Inc., Waltham, MA
³ImmunoGen, Waltham, MA
⁴University of Texas, MD Anderson Cancer Center, Houston, TX

Diana R. Dunshee^1*, Yumin Dai^2*, Jessica C. Jang^2*, Alberto Risueño^3*, Danny V Jeyaraju^2*, Patrick Hagner, PhD^2*, Wendy L. See^2*, Kyle MacBeth², Xiaomin Wang^2*, Ignazia La Torre^4*, Barry Skikne, MD^2,5*, C.L. Beach, PharmD^2*, Keshava Kumar, PhD^2*, Anjan Thakurta^2* and Daniel Lopes de Menezes, PhD^2*

¹Formerly Bristol Myers Squibb, Princeton, NJ
²Bristol Myers Squibb, Princeton, NJ
³BMS Center for Innovation and Translational Research Europe (CITRE), a Bristol Myers Squibb Company, Seville, Spain
⁴Celgene, a Bristol-Myers Squibb Company, Boudry, Switzerland
⁵Kansas University Medical Center, Kansas City, KS

Maximilian Alexander A Rohnert^1*, Malte von Bonin^2,3,4*, Michael Kramer^5*, Philipp Ensel^1*, Nadja Holtschke^6*, Christoph Rollig, MD, MSC^1*, Martin Bornhäuser, MD^5*, Veit Buecklein, MD^7*, Marion Subklewe, MD⁷, Stefan W Krause^8*, Simon Voelkl^8*, Tobias Berg^9,10, Michael A Rieger^11*, Cornelia Brendel^12*, Jörg Hoffmann^12*, Nicole Hofmeister-Mielke^13*, Richard F. Schlenk¹³, Sylvie D Freeman^14* and Uta Oelschlägel^6*

¹Department of Medicine I, University Hospital Carl Gustav Carus Dresden, Dresden, Germany
²Department of Medicine I, University Hospital Carl Gustav Carus Dresden, Dresden, Saxony, Germany
³German Cancer Research Center (DKFZ), Heidelberg, Germany
⁴German Cancer Consortium (DKTK), Dresden, Germany
⁵Department of Hematology and Oncology, University Hospital Carl Gustav Carus Dresden, Dresden, Germany
⁶Department of Medicine I, University Hospital Carl Gustav Carus Dresden,, Dresden, Germany
⁷Department of Medicine III, University Hospital, LMU Munich, Munich, Germany
⁸Department of Internal Medicine V, University Hospital Erlangen, Erlangen, Germany
⁹Department of Medicine II, Hematology/Oncology, Goethe University, Frankfurt, Bayern, Germany
¹⁰Stem Cell and Cancer Research Institute and Department of Oncology, McMaster University, Hamilton, ON, Canada
¹¹Department of Medicine II, Hematology/Oncology, Goethe University, Frankfurt, Germany
¹²Department of Internal Medicine and Hematology, Philipps University Marburg, Marburg, Germany
¹³Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany
¹⁴Institute of Immunology and Immunotherapy, University of Birmingham, Cheltenham, United Kingdom

Simone Ragaini, MD^1*, Sarah Wagner, BSc MSc^2*, Giovanni Marconi, MD³, Sarah Parisi, MD, PhD¹, Chiara Sartor, MD^1*, Jacopo Nanni, MD^1*, Gianluca Cristiano, MD^1*, Annalisa Talami, MD^1*, Matteo Olivi, MD^1*, Darina Ocadlikova, PhD^1*, Marilena Ciciarello, PhD^1*, Giulia Corradi, PhD^1*, Emanuela Ottaviani^4*, Cristina Papayannidis, MD, PhD^1*, Stefania Paolini, MD, PhD^1*, Jayakumar Vadakekolathu, PhD^2*, Michele Cavo^5*, Sergio Rutella, MD, PhD, FRCPath^2,6 and Antonio Curti, MD PhD⁷

¹Institute of Hematology “L. and A. Seràgnoli”, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy
²John van Geest Cancer Research Centre, Nottingham Trent University, Nottingham, United Kingdom
³Istituto di Ematologia e Oncologia Medica "Lorenzo e Ariosto Seràgnoli" Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy
⁴Institute of Hematology "L. e A. Seràgnoli", Department of Oncology and Hematology, Azienda Ospedaliero-Universitaria S. Orsola-Malpighi, Bologna, Italy
⁵Institute of Hematology “L. and A. Seràgnoli”, Department of Experimental, Diagnostic and Specialty Medicine, Policlino Sant Orsola Malpighi, Bologna, Italy
⁶Centre for Health, Ageing and Understanding Disease (CHAUD), Nottingham Trent University, Nottingham, United Kingdom
⁷Azienda Ospedaliero-Universitaria S. Orsola-Malpighi, Bologna, Italy

Raffaele Palmieri, MD^1*, Alfonso Piciocchi^2*, Valentina Arena, MS^3*, Luca Maurillo^4*, Maria Ilaria Del Principe^1*, Giovangiacinto Paterno^1*, Tiziana Ottone^1*, Mariadomenica Divona^1*, Serena Lavorgna^1*, Maria Irno Consalvo^1*, Consuelo Conti^1*, Cristina Attrotto^1*, Daniela Fraboni^1*, Maria Teresa Voso, MD⁵, William Arcese, MD, PhD^1,6, Adriano Venditti, MD ¹ and Francesco Buccisano, MD¹

¹Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
²Italian Group For Adult Hematologic Diseases (GIMEMA), Roma, ITA
³GIMEMA Foundation, Rome, Italy
⁴Hematology Department, Tor Vergata University Hospital, Rome, Italy, Rome, Italy
⁵University of Rome Tor Vergata, Rome, Italy
⁶Tor Vergata University of Rome, Rome Transplant Network, Rome, Italy

Ting Liu, MD^1*, Jianan Rao, Master^2*, Wenting Hu, MD^3*, Yuhan Liu, MD^3*, Huiying Sun, Master^4*, Xiaoxiao Chen, MD^5*, Yanjing Tang, MD, PhD^6*, Jing Chen, MD^7*, Xiang Wang, PhD^3*, Han Wang, Master^2*, Wubin Qian, PhD^8*, Binchen Mao, PhD^9*, Sheng Guo, PhD^8*, Ronghua Wang, Master^4*, Yu Liu, PhD^4* and Shuhong Shen, MD, PhD ^10,11,12

¹Key Laboratory of Pediatric Hematology & Oncology Ministry of Health, Department of Hematology & Oncology, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
²Pediatric Translational Medicine Institute, Shanghai Children’s Medical Center,, Shanghai Jiao Tong University School of Medicine, Shanghai, China
³Department of Hematology & Oncology, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⁴Pediatric Translational Medicine Institute, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⁵Department of Pediatric Hematology and Oncology, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⁶Hematology/oncology, Shanghai Children's Medical Center,Shanghai Jiaotong University School of Medicine, Shanghai, China
⁷Department of Hematology & Oncology,Shanghai Children’s Medical Center,, Shanghai Jiao Tong University school of Medicine, Shanghai, China
⁸Crown Bioscience Inc, Suzhou, China
⁹Crown Bioscience Inc., Shuzhou, China
¹⁰Key Laboratory of Pediatric Hematology and Oncology, Ministry of Health, Department of Pediatric Hematology and Oncology, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
¹¹National Children's Medical Center, Shanghai, China
¹²Pediatric Translational Medicine Institute, Shanghai Jiao Tong University School of Medicine,, Shanghai, China

Martina Pigazzi, PhD^1*, Maddalena Benetton^2*, Christiane Walter, MSc^3*, Maria Hansen^4*, Anne-Sofie Skou, MD^5*, Ambra Da Ros^2*, Anna Marchetti^6*, Katia Polato^2*, Mattia Belloni^7*, Claudia Tregnago, PhD^8*, Jonas Abrahamsson, MD, PhD^9*, Linda Fogelstrand¹⁰, Nils Von Neuhoff, PhD^11*, Dirk Reinhardt, MD PhD³, Henrik Hasle, MD¹², Franco Locatelli, MD^13,14* and Pietro Merli, MD^15*

¹Women and Child Health Department, Hematology-Oncology Clinic and Lab, University of Padova, Padova, ITALY, Italy
²Women and Child Health Department, Hematology-Oncology Clinic and Lab, University of Padova, Padova, Italy
³Pediatric Hematology/Oncology, University Children's Hospital, Essen, Germany
⁴HematoDiagnostic Laboratory, Aarhus University Hospital, Aarhus, Denmark
⁵Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus N, Denmark
⁶Istituto di Ricerca Pediatrica - Città della Speranza, Padova, Italy
⁷Woman and Child Health Department, OncoHematology Lab, University of Padova, Padova, Italy
⁸Woman and Child Health Department, OncoHematology Lab, Università degli Studi di Padova, Padova, Italy
⁹Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
¹⁰Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
¹¹Department of Pediatric Hematology and Oncology, University Hospital Essen, Essen, Germany
¹²Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark
¹³La Sapienza, University of Rome, Rome, Italy
¹⁴Pediatric Hemato-Oncology, IRCCS, Bambino Gesù Children’s Hospital, Sapienza, Univ of Rome, Rome, Italy
¹⁵Department of Pediatric Hematology/Oncology, Cell and Gene Therapy, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy

Ana Rio-Machin^1*, Pedro Casado-Izquierdo^1*, Juho Miettinen, PhD^2*, Findlay Bewicke-Copley, PhD, MSc, BSc^3,4, Naeem Khan, PhD^5*, Jonas Demeulemeester^6*, Szilvia Krizsán, MD^7*, Jiexin Zheng^1*, Christopher Middleton^5*, Wencheng Yin^5*, William Grey^8*, Farideh Miraki-Moud, PhD^9*, Janet Matthews^1*, Marianne Grantham^10*, Kevin Rouault-Pierre, PhD^11*, Krister Wennerberg^12*, Alun Parsons^13*, Hannah Armes^1*, Karina EM Close^1*, Doriana Di Bella^1*, James Cavenagh¹⁴, Sylvie D Freeman^15*, Peter Van Loo^8*, Csaba Bodor, PhD^16*, Kimmo Porkka^17*, Caroline A Heckman, PhD¹⁸, Jun Wang, PhD^4*, David Taussig^19*, Dominique Bonnet, PhD²⁰, Jean-Baptiste Cazier, PhD^21*, Pedro Cutillas, PhD^22* and Jude Fitzgibbon, PhD^23*

¹Barts Cancer Institute, Queen Mary University of London, London, United Kingdom
²Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
³Centre for Cancer Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom
⁴Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom
⁵University of Birmingham, Birmingham, United Kingdom
⁶The Francis Crick Institute, London, GBR
⁷MTA-SE Momentum Molecular Oncohematology Research Group, 1st Department of Pathology and Cancer Research, Semmelweis University, Budapest, Hungary
⁸Francis Crick Institute, London, United Kingdom
⁹Institute of Cancer Research, London, United Kingdom
¹⁰Barts Health NHS Trust, LONDON, GBR
¹¹Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom
¹²Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark
¹³Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland
¹⁴Department of Haemato-Oncology, St Bartholomew's Hospital, Barts Health NHS Trust, London, United Kingdom
¹⁵Institute of Immunology and Immunotherapy, University of Birmingham, Cheltenham, United Kingdom
¹⁶Semmelweis University, Budapest, Hungary
¹⁷University of Helsinki, Helsinki, Finland
¹⁸Institute for Molecular Medicine Finland,, University of Helsinki, Helsinki, Finland
¹⁹The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom
²⁰CRUK, London, United Kingdom
²¹Centre for Computational Biology, University of Birmingham, Birmingham, United Kingdom
²²Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom
²³Queen Mary University of London,, London, United Kingdom

Pawan Kumar Upadhyay, PhD^*, Jeremy Beales, MS^*, Nakul Kumar Shah, MD^*, Christopher A Miller, PhD^*, Allegra A Petti, PhD^*, Daniel C. Link, MD, Timothy J Ley, MD and John Welch, MD PhD^*

Washington University School of Medicine, St Louis, MO

Marius Bill, MD, PhD^1*, Jessica Kohlschmidt, PhD^2,3, Krzysztof Mrózek, MD, PhD², Deedra Nicolet, MS^2*, Christopher J. Walker, PhD¹, Dimitrios Papaioannou, MD^1*, James S. Blachly, MD⁴, Shelley Orwick, BS^5*, Eunice S. Wang, MD⁶, Jonathan E. Kolitz, MD⁷, Bayard L. Powell, MD⁸, Andrew J Carroll, PhD⁹, Ramiro Garzon, MD², Richard M. Stone, MD¹⁰, John C. Byrd, MD⁵, Clara D. Bloomfield, MD¹¹ and Ann-Kathrin Eisfeld, MD⁵

¹The Ohio State University, Comprehensive Cancer Center, Columbus, OH
²The Ohio State University Comprehensive Cancer Center, Columbus, OH
³Alliance Statistics and Data Center, The Ohio State University Comprehensive Cancer Center, Columbus, OH
⁴Department of Internal Medicine, The Ohio State University, Columbus, OH
⁵Division of Hematology, The Ohio State University, Columbus, OH
⁶Roswell Park Comprehensive Cancer Center, BUFFALO, NY
⁷Northwell Health Cancer Institute, Zucker School of Medicine at Hofstra/Northwell, Lake Success, NY
⁸Wake Forest Univ. School of Med., Winston Salem, NC
⁹Department of Genetics, University of Alabama at Birmingham, Birmingham, AL
¹⁰Department of Medical Oncology, Dana-Farber Cancer Institute, Boston
¹¹Comprehensive Cancer Center, The Ohio State University, Columbus, OH

Anna Dolnik^1*, Nikolaus Jahn, MD^2*, Eric Sträng, PhD^1*, Sibylle Cocciardi, PhD^2*, Frank G. Rücker, MD^2*, Ekaterina Panina, MD^2*, Tamara J. Blätte, PhD^1*, Julia Katharina Herzig, PhD^2*, Andrea Corbacioglu, PhD^2*, Daniela Weber, MSc^2*, Anika Schrade, PhD^2*, Verena I Gaidzik, MD², Sabrina Skambraks^2*, Katharina S. Götze³, Michael Luebbert, MD, PhD⁴, Walter Fiedler, MD⁵, Thomas Schroeder^6*, Corinna Hahn^7*, Felicitas Thol⁸, Michael Heuser⁸, Arnold Ganser⁸, Peter Paschka, MD², Hartmut Döhner², Konstanze Dohner, MD² and Lars Bullinger, MD¹

¹Department of Hematology, Oncology and Tumor Immunology, Charité University Medicine Berlin, Berlin, Germany
²Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany
³Department of Internal Medicine III, Hematology and Medical Oncology, University Hospital Rechts der Isar, Munich, Germany
⁴Department of Internal Medicine I, Division of Hematology and Oncology, University Hospital of Freiburg, Freiburg, Germany
⁵Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
⁶Department of Hematology, Oncology and Clinical Immunology, University Hospital Düsseldorf, Medical Faculty, Düsseldorf, Germany
⁷Department of Internal Medicine III, University of Bonn, Bonn, Germany
⁸Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany

Ghayas C. Issa, MD¹, Vakul Mohanty, PhD^2*, Yuanxin Wang^3*, Zoe Alaniz, BS^4*, Jabra Zarka, MD^5*, Jake Leighton^6*, Nicholas Navin, PhD^6*, Marina Konopleva, MD, PhD⁷, Ken Chen, PhD^2* and Michael Andreeff, MD, PhD⁴

¹Department of Leukemia, Universit Y of Texas At Houston, Houston, TX
²Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁶Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX
⁷Department of Leukemia, University of Texas, MD Anderson Cancer Center, Houston, TX

Ryosaku Inagaki, MSc^1,2,3*, Masahiro Marshall Nakagawa, MD, PhD^1,2, Yasuhito Nannya, MD, PhD¹, Qi Xingxing, PhD^1*, Lanying Zhao, M.D., Ph.D^1*, June Takeda, MD^1*, Akinori Yoda, PhD^1*, Ayana Kon, MD, PhD^1*, Hisashi Tsurumi, MD, PhD⁴, Hideki Makishima, MD, PhD¹ and Seishi Ogawa, MD, PhD^1,5,6

¹Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
²DSK Project, Medical Innovation Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan
³DSP Cancer Institute, Sumitomo Dainippon Pharma Co., Ltd., Osaka, Japan
⁴Hematology, Gifu University Graduate School of Medicine, Gifu, Japan
⁵Department of Medicine, Center for Haematology and Regenerative Medicine, Karolinska Institutet, Stockholm, Sweden
⁶Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan

Geethu Emily Thomas, PhD, MSc, BSc¹, Grace Egan, MD², Laura Garcia Prat, PhD, BSc, MSc³, Botham Aaron^4*, Veronique Voisin, PhD^5*, Elias Orouji^6*, Jordan M Chin^6*, Boaz Nachmias, MD, PhD^7*, Kerstin B Kaufmann, PhD³, Fieke W Hoff, BSc^8*, Neil Maclean^7*, Rose Hurren, BSc^7*, Xiaoming Wang^7*, Marcela Gronda, MSc^7*, Andrea Arruda, MSc^9*, Mark D. Minden¹⁰, Gary D Bader^11*, Steven M. Kornblau, MD¹², John E. Dick, PhD, FRS³ and Aaron D Schimmer, MD, PhD¹⁰

¹Princess Margaret Cancer Research Centre, University Health Network, Toronto, ON, Canada
²Hospital For Sick Children, Toronto, ON, Canada
³Princess Margaret Cancer Centre, University Health Network (UHN), Toronto, ON, Canada
⁴University Health Network, Toronto, ON, Canada
⁵Terrence Donnelly Centre for Cellular and Biomedical Research, University of Toronto, Toronto, ON, Canada
⁶Princess Margaret Cancer Research Centre, Toronto, ON, Canada
⁷Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
⁸Department of Pediatric Oncology/ Hematology, University Medical Center Groningen, Groningen, Netherlands
⁹Princess Margaret Cancer Centre, Division of Medical Oncology and Hematology, University Health Network, University of Toronto, Toronto, ON, Canada
¹⁰Leukemia Program, Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
¹¹The Donnelly Centre, University of Toronto, Toronto, ON, Canada
¹²Department of Stem Cell Transplantation, M.D. Anderson Cancer Center University of Texas, Houston, TX

Sung Choe, PhD^1*, Hongfang Wang, PhD^1*, Gail J. Roboz, MD², Courtney D. DiNardo, MD, MSc³, Eytan M. Stein, MD⁴, Alice S. Mims, MD⁵, Gabrielle T. Prince, MD^6*, Justin M. Watts, MD^7*, Bin Fan, PhD^1*, Parham Nejad, BSc^1*, Vickie Zhang, PhD^8*, Hua Liu, PhD^1*, Eyal C. Attar, MD^1*, Bin Wu, PhD^8* and Richard M. Stone, MD⁹

¹Agios Pharmaceuticals, Inc, Cambridge, MA
²Weill Medical College of Cornell University New York-Presbyterian Hospital, New York, NY
³Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX
⁴Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY
⁵Ohio State University Wexner Medical Center, Columbus, OH
⁶Johns Hopkins Hospital, Baltimore, MD
⁷University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL
⁸Agios Pharmaceuticals, Inc., Cambridge, MA
⁹Dana-Farber/Partners CancerCare, Boston, MA

Ting Zhang, MD^*, Yuntao Liu^*, Shuning Wei^*, Benfa Gong^*, Chunlin Zhou^*, Ying Wang, MD, Hui Wei, MD^*, Yingchang Mi and Jianxiang Wang, MD

State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China

Klaus H. Metzeler, MD¹, Maja Rothenberg-Thurley, PhD^1*, Dennis Görlich, PhD^2*, Maria Cristina Sauerland^2*, Annika Maria Dufour, PhD^1*, Stephanie Schneider, PhD^1*, Marion Subklewe, MD¹, Jan Braess, MD^3*, Bernhard J. Wörmann, MD^4*, Wolfgang E. Berdel, Prof., MD⁵, Utz Krug, MD⁶, Wolfgang Hiddemann, MD, PhD¹, Karsten Spiekermann, MD¹ and Tobias Herold, MD¹

¹Laboratory for Leukemia Diagnostics, Department of Hematology and Oncology, University Hospital, LMU Munich, Munich, Germany
²Institute of Biostatistics and Clinical Research, University of Münster, Münster, Germany
³Krankenhaus Barmherzige Brueder, Regensburg, Germany
⁴Department of Hematology, Oncology and Tumor Immunology, Charité University Medicine, Berlin, Germany
⁵Department of Medicine A, University Hospital Muenster, Muenster, Germany
⁶Department of Medicine 3, Klinikum Leverkusen, Leverkusen, Germany

Louise Pettersson^1,2*, Sofie Johansson Alm^3*, Alvar Almstedt^4*, Vladimir Lazarevic^5*, Gustav Orrsjö^6*, Giti Shah-Barkhordar^7*, Linda Fogelstrand^8,9 and Mats Ehinger^10,11*

¹Department of Oncology and Pathology, Lund University, Lund, Sweden
²Hallands sjukhus Halmstad, Halmstad, Sweden
³Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
⁴SciLife Clinical Genomics Gothenburg, Gothenburg, Sweden
⁵Department of Hematology, Oncology and Radiation Physics, Skane University Hospital, Lund, Sweden
⁶Section for hematology and coagulation, Sahlgrenska University Hospital, Gothemburg, Sweden
⁷Department of Clinical genetics and genomics, Sahlgrenska University Hospital, Gothenburg, Sweden
⁸Department of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden
⁹Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
¹⁰Department of Oncology and Pathology, Lund University Hospital, Lund, Sweden
¹¹Klinisk Patologi, Region laboratories, Region Skåne, Lund, Sweden

Nam K Nguyen, MS, PharmD¹, Abdelrahman H Elsayed, MSc¹, Soheil Meshinchi, MD, PhD² and Jatinder K Lamba, MSc, PhD¹

¹Department of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, Gainesville, FL
²Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA

Bor-Sheng Ko, MD, PhD^1,2*, Yu-Fen Wang, MS^3,4*, Jeng-Lin Li, BS^5*, Hsin-An Hou^6*, Wen-Chien Chou, MD, PhD⁷, Hwei-Fang Tien, M.D., Ph.D.¹, Ting-Yu Chang, M.S.^3* and Chi-Chun Lee, Ph.D.^5*

¹Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
²Department of Hematological Oncology, National Taiwan University Cancer Center, Taipei, Taiwan
³AHEAD Medicine, Berkeley, CA
⁴Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
⁵Department of Electrical Engineering, National Tsing Hua University, Hsinchu, Taiwan
⁶National Taiwan University Hospital, Taipei, TWN
⁷Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan

Michael Castro, MD^1*, Drew Watson, Ph.D.^2*, Ansu Kumar, M.Sc.^3*, Prashant Ramachandran Nair, B.Tech.^3*, Himanshu Grover, M.S.^3*, Diwyanshu Sahu, M.Sc.^3*, Subrat Mohapatra, M.Sc.^3*, Poornachandra G, B.Tech.^3*, Ashish Agarwal, B.V.Sc.^3*, Rakhi Purushothaman Suseela, B.Tech.^3*, Naga Ganesh, B.Tech.^3*, Mohammed Sauban, B.E.^3*, Chandan Kumar, M.Tech.^3*, Rahul K Raman, M.Sc.^3*, Divya Singh, M.S.^3*, Sayani Basu, M.Tech.^3*, Neelesh Lunkad, M.Tech.^3*, Nirjhar Mundkur, B.S.^2*, Michele Dundas Macpherson, B.A.Sc.^2*, Shweta Kapoor, M.Sc.^3* and Scott Howard, MD⁴

¹Personalized Cancer Medicine, PLLC, Los Angeles, CA
²Cellworks Group Inc., South San Francisco, CA
³Cellworks Research India Private Limited, Bangalore, India
⁴University of Tennessee Health Science Center, Memphis, TN